CSNK1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.49020965
2cell migration in hindbrain (GO:0021535)4.24255725
3regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.09754204
4convergent extension (GO:0060026)3.47198863
5layer formation in cerebral cortex (GO:0021819)3.43977583
6cochlea morphogenesis (GO:0090103)3.42978065
7Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.29335695
8heterochromatin organization (GO:0070828)3.21648769
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17063754
10regulation of establishment of planar polarity (GO:0090175)3.10637896
11lung-associated mesenchyme development (GO:0060484)3.09823897
12regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96137811
13semaphorin-plexin signaling pathway (GO:0071526)2.95977296
14outer ear morphogenesis (GO:0042473)2.92217899
15regulation of NFAT protein import into nucleus (GO:0051532)2.90158806
16camera-type eye morphogenesis (GO:0048593)2.87749479
17positive regulation of synapse maturation (GO:0090129)2.83340979
18paraxial mesoderm development (GO:0048339)2.80122516
19postsynaptic membrane organization (GO:0001941)2.78793424
20establishment of tissue polarity (GO:0007164)2.78001321
21establishment of planar polarity (GO:0001736)2.78001321
22hemidesmosome assembly (GO:0031581)2.76897118
23regulation of sister chromatid cohesion (GO:0007063)2.75145849
24central nervous system projection neuron axonogenesis (GO:0021952)2.72929139
25cranial nerve morphogenesis (GO:0021602)2.72080675
26dendritic spine morphogenesis (GO:0060997)2.67902224
27protein-DNA complex disassembly (GO:0032986)2.67641798
28nucleosome disassembly (GO:0006337)2.67641798
29neuron projection extension involved in neuron projection guidance (GO:1902284)2.67178031
30axon extension involved in axon guidance (GO:0048846)2.67178031
31mitotic metaphase plate congression (GO:0007080)2.66410253
32peptidyl-arginine methylation (GO:0018216)2.65659303
33peptidyl-arginine N-methylation (GO:0035246)2.65659303
34axonal fasciculation (GO:0007413)2.64506889
35non-canonical Wnt signaling pathway (GO:0035567)2.64463157
36neural tube development (GO:0021915)2.64229145
37adherens junction assembly (GO:0034333)2.63627078
38peptidyl-arginine omega-N-methylation (GO:0035247)2.62188108
39establishment of monopolar cell polarity (GO:0061162)2.62035354
40establishment or maintenance of monopolar cell polarity (GO:0061339)2.62035354
41lymph vessel development (GO:0001945)2.60468642
42pre-miRNA processing (GO:0031054)2.58925413
43dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58211734
44regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57202553
45establishment of apical/basal cell polarity (GO:0035089)2.54017348
46histone H2A monoubiquitination (GO:0035518)2.53018939
47regulation of axon extension involved in axon guidance (GO:0048841)2.51545270
48negative regulation of catenin import into nucleus (GO:0035414)2.50975338
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50263509
50neuron cell-cell adhesion (GO:0007158)2.49667531
51skeletal muscle organ development (GO:0060538)2.48663790
52regulation of hippo signaling (GO:0035330)2.46809453
53neuron recognition (GO:0008038)2.43717786
54establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43550862
55regulation of DNA methylation (GO:0044030)2.43011074
56regulation of axon guidance (GO:1902667)2.39939195
57protein retention in ER lumen (GO:0006621)2.39517416
58establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38601404
59establishment or maintenance of bipolar cell polarity (GO:0061245)2.38601404
60histone arginine methylation (GO:0034969)2.38542230
61body morphogenesis (GO:0010171)2.37061354
62vocalization behavior (GO:0071625)2.36726885
63atrioventricular valve morphogenesis (GO:0003181)2.35780306
64regulation of meiosis (GO:0040020)2.35764390
65apical protein localization (GO:0045176)2.35600883
66hippo signaling (GO:0035329)2.34654568
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.33956059
68mitotic spindle checkpoint (GO:0071174)2.32728229
69neuron projection extension (GO:1990138)2.32284703
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.30833496
71mating behavior (GO:0007617)2.30789166
72spindle checkpoint (GO:0031577)2.30228997
73ectodermal placode formation (GO:0060788)2.28549444
74cell junction maintenance (GO:0034331)2.27953782
75endothelial cell chemotaxis (GO:0035767)2.27811328
76protein localization to microtubule (GO:0035372)2.25761631
77cell-cell junction maintenance (GO:0045217)2.25680348
78positive regulation of chromosome segregation (GO:0051984)2.25662503
79negative regulation of chromosome segregation (GO:0051985)2.25119904
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.24797421
81eye morphogenesis (GO:0048592)2.24141422
82apoptotic process involved in morphogenesis (GO:0060561)2.24122013
83mitotic sister chromatid segregation (GO:0000070)2.23930331
84spinal cord development (GO:0021510)2.23805409
85negative regulation of microtubule polymerization (GO:0031115)2.23581105
86dopamine receptor signaling pathway (GO:0007212)2.23310965
87regulation of synapse maturation (GO:0090128)2.23121166
88synaptic vesicle docking involved in exocytosis (GO:0016081)2.22302043
89cell migration involved in sprouting angiogenesis (GO:0002042)2.21907718
90microtubule depolymerization (GO:0007019)2.21456654
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21252717
92establishment of nucleus localization (GO:0040023)2.21240614
93kidney mesenchyme development (GO:0072074)2.20903776
94glial cell proliferation (GO:0014009)2.20512203
95cell-substrate adherens junction assembly (GO:0007045)2.20406318
96focal adhesion assembly (GO:0048041)2.20406318
97regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.20236302
98regulation of translational fidelity (GO:0006450)2.20008628
99RNA localization (GO:0006403)2.19930885
100protein localization to kinetochore (GO:0034501)2.19803910
101gastrulation with mouth forming second (GO:0001702)2.19786954
102renal system development (GO:0072001)2.19353741
103mitotic spindle assembly checkpoint (GO:0007094)2.19270619
104lateral sprouting from an epithelium (GO:0060601)2.19167538
105ephrin receptor signaling pathway (GO:0048013)2.17982369
106intracellular estrogen receptor signaling pathway (GO:0030520)2.17819368
107head development (GO:0060322)2.17465855
108protein complex localization (GO:0031503)2.17303785
109positive regulation of cell cycle G2/M phase transition (GO:1902751)2.17178782
110positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.17178782
111cerebellar granule cell differentiation (GO:0021707)2.16781444
112pattern specification involved in kidney development (GO:0061004)2.16660954
113lens fiber cell development (GO:0070307)2.16332949
114regulation of chromosome segregation (GO:0051983)2.16300687
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.16187716
116sister chromatid segregation (GO:0000819)2.15989736
117negative regulation of histone methylation (GO:0031061)2.15930843
118cell-substrate junction assembly (GO:0007044)2.15236897
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.14397001
120mitochondrion transport along microtubule (GO:0047497)2.14397001
121ribosomal small subunit biogenesis (GO:0042274)2.14318796
122embryonic body morphogenesis (GO:0010172)2.13194315
123diaphragm development (GO:0060539)2.12742860
124spindle assembly checkpoint (GO:0071173)2.12160310
125myelination in peripheral nervous system (GO:0022011)2.10959641
126peripheral nervous system axon ensheathment (GO:0032292)2.10959641
127locomotory exploration behavior (GO:0035641)2.10384166
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.10264943
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.10264943
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.10264943
131negative regulation of sister chromatid segregation (GO:0033046)2.10264943
132cellular protein complex localization (GO:0034629)2.09892720
133regulation of spindle organization (GO:0090224)2.09689919
134neuronal ion channel clustering (GO:0045161)2.09608724
135regulation of catenin import into nucleus (GO:0035412)2.09565034
136developmental cell growth (GO:0048588)2.09010779
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.08627893
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.08526565
139negative regulation of meiosis (GO:0045835)2.07908088
140dendrite morphogenesis (GO:0048813)2.07879572
141central nervous system neuron axonogenesis (GO:0021955)2.07445882
142regulation of exit from mitosis (GO:0007096)2.07278295
143metaphase plate congression (GO:0051310)2.07265185
144branching involved in salivary gland morphogenesis (GO:0060445)2.07045552
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.06506892
146negative regulation of chondrocyte differentiation (GO:0032331)2.06145222
147asymmetric protein localization (GO:0008105)2.05884473
148blood vessel endothelial cell migration (GO:0043534)2.05775404
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.05683887
150regulation of glutamate receptor signaling pathway (GO:1900449)2.04994065
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.04634221
152protein localization to synapse (GO:0035418)2.03853635
153positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.02768378
154negative regulation of Ras GTPase activity (GO:0034261)2.02523095
155axon extension (GO:0048675)2.02496676
156notochord development (GO:0030903)2.02010568
157regulation of microtubule polymerization (GO:0031113)2.01101752
158cerebral cortex radially oriented cell migration (GO:0021799)2.00908639
159positive regulation of microtubule polymerization (GO:0031116)2.00735574
160regulation of meiotic cell cycle (GO:0051445)2.00363042
161ventricular cardiac muscle cell development (GO:0055015)1.97880278
162regulation of RNA export from nucleus (GO:0046831)1.97815079
163peptidyl-arginine modification (GO:0018195)1.97298479
164regulation of mitotic metaphase/anaphase transition (GO:0030071)1.97099026
165regulation of sister chromatid segregation (GO:0033045)1.96849291
166regulation of mitotic sister chromatid separation (GO:0010965)1.96849291
167regulation of mitotic sister chromatid segregation (GO:0033047)1.96849291
168cartilage morphogenesis (GO:0060536)1.96583630
169histone H4-K8 acetylation (GO:0043982)1.96314687
170histone H4-K5 acetylation (GO:0043981)1.96314687
171histone H2A ubiquitination (GO:0033522)1.96307781
172polarized epithelial cell differentiation (GO:0030859)1.95894807
173proximal/distal pattern formation (GO:0009954)1.95550591
174DNA damage induced protein phosphorylation (GO:0006975)1.95460402
175establishment of mitochondrion localization (GO:0051654)1.95240436
176protein localization to chromosome (GO:0034502)1.94940316
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.94575306
178negative regulation of glial cell proliferation (GO:0060253)1.93994486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76460680
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.43788308
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.34776034
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.46151025
5SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.39028640
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37871066
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.29413807
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.24717008
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19128723
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.15961355
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12542849
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.09582385
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.02828815
14LXR_22292898_ChIP-Seq_THP-1_Human2.00691488
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98043740
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97835976
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97627029
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93163902
19* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89364356
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89076720
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79158471
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78311254
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78311254
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75749974
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75235794
26RACK7_27058665_Chip-Seq_MCF-7_Human1.71437452
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70998944
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69904483
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.67681651
30RING1B_27294783_Chip-Seq_NPCs_Mouse1.66443659
31KDM2B_26808549_Chip-Seq_K562_Human1.63379294
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61933337
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61632985
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61302704
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60215446
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57548081
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54563621
38CTCF_27219007_Chip-Seq_Bcells_Human1.53322808
39* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52728354
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51955563
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.50624078
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.48594249
43* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47441191
44CREB1_26743006_Chip-Seq_LNCaP_Human1.43309357
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42562395
46REST_21632747_ChIP-Seq_MESCs_Mouse1.38902007
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37542937
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37497736
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.36972570
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35545046
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34130011
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.33866166
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33865724
54* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33794148
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.33495052
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.33436578
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32956255
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32121607
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31989019
60E2F7_22180533_ChIP-Seq_HELA_Human1.30934218
61TP53_22127205_ChIP-Seq_IMR90_Human1.29684143
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.28872217
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.28432615
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.27882243
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.27852606
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27236243
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26283489
68P68_20966046_ChIP-Seq_HELA_Human1.25659273
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25454803
70CLOCK_20551151_ChIP-Seq_293T_Human1.24658870
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24270882
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24270882
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24270882
74XRN2_22483619_ChIP-Seq_HELA_Human1.24248369
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.23666895
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23330777
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23077760
78ZNF263_19887448_ChIP-Seq_K562_Human1.22755986
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22599904
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22483523
81* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22326493
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21721651
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20751267
84* SMC4_20622854_ChIP-Seq_HELA_Human1.20372901
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.19416406
86RNF2_27304074_Chip-Seq_NSC_Mouse1.19233629
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19156568
88* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19139337
89* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18459785
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17778286
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17222362
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16851445
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16126016
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14910276
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14278828
96* KDM2B_26808549_Chip-Seq_DND41_Human1.13972554
97* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13562466
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.12746599
99* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12230053
100* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12153576
101VDR_21846776_ChIP-Seq_THP-1_Human1.12141442
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12028311
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11175831
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10688013
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.10097341
106ZNF274_21170338_ChIP-Seq_K562_Hela1.09626294
107* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09129193
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.08874635
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08353265
110* TCF7_22412390_ChIP-Seq_EML_Mouse1.06621870
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06476345
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05234647
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04848333
114POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04561644
115SOX3_22085726_ChIP-Seq_NPCs_Mouse1.04493330
116MYC_18555785_ChIP-Seq_MESCs_Mouse1.03588941
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03313224
118DROSHA_22980978_ChIP-Seq_HELA_Human1.03292434
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02828426
120* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02589437
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02463173
122* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02400017
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99699693
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99091777
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97240469
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.96404619
127* SOX2_16153702_ChIP-ChIP_HESCs_Human0.95976393
128MYC_22102868_ChIP-Seq_BL_Human0.95355749
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94447422
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93321176
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92713200
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92656199
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92324988
134E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91961971
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91694711
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.91501708
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90168847
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89374402
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88144867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.95641711
2MP0002653_abnormal_ependyma_morphology2.79692239
3MP0004859_abnormal_synaptic_plasticity2.73736849
4MP0000566_synostosis2.72042115
5MP0000579_abnormal_nail_morphology2.20664894
6MP0003123_paternal_imprinting2.19583777
7MP0000778_abnormal_nervous_system2.01977560
8MP0003111_abnormal_nucleus_morphology1.93895016
9MP0005409_darkened_coat_color1.90880080
10MP0002102_abnormal_ear_morphology1.90024265
11MP0000537_abnormal_urethra_morphology1.88578362
12MP0003121_genomic_imprinting1.85334173
13MP0000678_abnormal_parathyroid_gland1.84072615
14MP0010030_abnormal_orbit_morphology1.81956020
15MP0005423_abnormal_somatic_nervous1.81008397
16MP0003283_abnormal_digestive_organ1.62887245
17MP0004272_abnormal_basement_membrane1.62596558
18MP0002697_abnormal_eye_size1.59023936
19MP0006292_abnormal_olfactory_placode1.58217183
20MP0000762_abnormal_tongue_morphology1.57749377
21MP0003787_abnormal_imprinting1.55682697
22MP0003938_abnormal_ear_development1.53882048
23MP0004270_analgesia1.53687995
24MP0001346_abnormal_lacrimal_gland1.53141124
25MP0003861_abnormal_nervous_system1.52888535
26MP0003693_abnormal_embryo_hatching1.52692608
27MP0003119_abnormal_digestive_system1.52085772
28MP0003635_abnormal_synaptic_transmissio1.51801348
29MP0003122_maternal_imprinting1.49433963
30MP0005257_abnormal_intraocular_pressure1.47223322
31MP0002184_abnormal_innervation1.46523126
32MP0003880_abnormal_central_pattern1.43341650
33MP0003718_maternal_effect1.42271339
34MP0010094_abnormal_chromosome_stability1.42065987
35MP0003937_abnormal_limbs/digits/tail_de1.42008833
36MP0003385_abnormal_body_wall1.38328768
37MP0003755_abnormal_palate_morphology1.38289487
38MP0003077_abnormal_cell_cycle1.37006298
39MP0002085_abnormal_embryonic_tissue1.34449561
40MP0001299_abnormal_eye_distance/1.34420168
41MP0002089_abnormal_postnatal_growth/wei1.34159300
42MP0009379_abnormal_foot_pigmentation1.33781774
43MP0004885_abnormal_endolymph1.32652690
44MP0002084_abnormal_developmental_patter1.31034625
45MP0005623_abnormal_meninges_morphology1.30936317
46MP0002063_abnormal_learning/memory/cond1.26864446
47MP0002249_abnormal_larynx_morphology1.25727604
48MP0003567_abnormal_fetal_cardiomyocyte1.25612728
49MP0000003_abnormal_adipose_tissue1.25428418
50MP0009278_abnormal_bone_marrow1.24184580
51MP0004233_abnormal_muscle_weight1.22074140
52MP0004858_abnormal_nervous_system1.19496088
53MP0000569_abnormal_digit_pigmentation1.18946966
54MP0004957_abnormal_blastocyst_morpholog1.18850055
55MP0008438_abnormal_cutaneous_collagen1.17588364
56MP0003890_abnormal_embryonic-extraembry1.16518175
57MP0000955_abnormal_spinal_cord1.13813825
58MP0003935_abnormal_craniofacial_develop1.13523354
59MP0003878_abnormal_ear_physiology1.13452867
60MP0005377_hearing/vestibular/ear_phenot1.13452867
61MP0002152_abnormal_brain_morphology1.12920119
62MP0005503_abnormal_tendon_morphology1.12634563
63MP0000733_abnormal_muscle_development1.12567967
64MP0000534_abnormal_ureter_morphology1.12146171
65MP0003315_abnormal_perineum_morphology1.12041890
66MP0000049_abnormal_middle_ear1.12028826
67MP0002877_abnormal_melanocyte_morpholog1.10942872
68MP0002116_abnormal_craniofacial_bone1.10418222
69MP0002734_abnormal_mechanical_nocicepti1.09847984
70MP0003942_abnormal_urinary_system1.09398518
71MP0001672_abnormal_embryogenesis/_devel1.09316552
72MP0005380_embryogenesis_phenotype1.09316552
73MP0008932_abnormal_embryonic_tissue1.06718841
74MP0001348_abnormal_lacrimal_gland1.06703918
75MP0009053_abnormal_anal_canal1.06365656
76MP0009672_abnormal_birth_weight1.04717072
77MP0008789_abnormal_olfactory_epithelium1.04169203
78MP0005076_abnormal_cell_differentiation1.04075444
79MP0003941_abnormal_skin_development1.03263085
80MP0002092_abnormal_eye_morphology1.03200885
81MP0010368_abnormal_lymphatic_system1.03188941
82MP0000350_abnormal_cell_proliferation1.01919430
83MP0004811_abnormal_neuron_physiology1.01033145
84MP0004145_abnormal_muscle_electrophysio1.00972117
85MP0001697_abnormal_embryo_size1.00507513
86MP0000428_abnormal_craniofacial_morphol0.99816514
87MP0001730_embryonic_growth_arrest0.99426112
88MP0000467_abnormal_esophagus_morphology0.99412088
89MP0002572_abnormal_emotion/affect_behav0.98907380
90MP0002822_catalepsy0.97368244
91MP0008877_abnormal_DNA_methylation0.97015970
92MP0002111_abnormal_tail_morphology0.96548689
93MP0005508_abnormal_skeleton_morphology0.96511242
94MP0005394_taste/olfaction_phenotype0.95707878
95MP0005499_abnormal_olfactory_system0.95707878
96MP0002081_perinatal_lethality0.94261180
97MP0002932_abnormal_joint_morphology0.93024338
98MP0004185_abnormal_adipocyte_glucose0.92687279
99MP0009250_abnormal_appendicular_skeleto0.92359757
100MP0002882_abnormal_neuron_morphology0.92082830
101MP0004133_heterotaxia0.91290579
102MP0001879_abnormal_lymphatic_vessel0.90980545
103MP0003984_embryonic_growth_retardation0.90056433
104MP0000751_myopathy0.89449764
105MP0002088_abnormal_embryonic_growth/wei0.89383184
106MP0002234_abnormal_pharynx_morphology0.88425917
107MP0002733_abnormal_thermal_nociception0.88233630
108MP0005187_abnormal_penis_morphology0.88139235
109MP0002557_abnormal_social/conspecific_i0.87594853
110MP0003566_abnormal_cell_adhesion0.87230006
111MP0002114_abnormal_axial_skeleton0.87000584
112MP0000631_abnormal_neuroendocrine_gland0.86598357
113MP0002751_abnormal_autonomic_nervous0.86021384
114MP0003646_muscle_fatigue0.85952060
115MP0003115_abnormal_respiratory_system0.84300805
116MP0001440_abnormal_grooming_behavior0.84234906
117MP0000516_abnormal_urinary_system0.84008051
118MP0005367_renal/urinary_system_phenotyp0.84008051
119MP0000432_abnormal_head_morphology0.83947001
120MP0001486_abnormal_startle_reflex0.83934071
121MP0002233_abnormal_nose_morphology0.83677611
122MP0001340_abnormal_eyelid_morphology0.83478078
123MP0001849_ear_inflammation0.82960481
124MP0001485_abnormal_pinna_reflex0.82424124
125MP0002098_abnormal_vibrissa_morphology0.81794776
126MP0002108_abnormal_muscle_morphology0.81620995
127MP0001188_hyperpigmentation0.81534819
128MP0005375_adipose_tissue_phenotype0.80558884
129MP0005248_abnormal_Harderian_gland0.80271294
130MP0001970_abnormal_pain_threshold0.79621497
131MP0002177_abnormal_outer_ear0.78947921
132MP0001286_abnormal_eye_development0.78878513
133MP0004197_abnormal_fetal_growth/weight/0.78422936
134MP0001293_anophthalmia0.78229129
135MP0009046_muscle_twitch0.78185496
136MP0003634_abnormal_glial_cell0.77909720
137MP0000462_abnormal_digestive_system0.77605029
138MP0002796_impaired_skin_barrier0.77463671
139MP0005501_abnormal_skin_physiology0.77112798
140MP0009384_cardiac_valve_regurgitation0.73488577
141MP0005670_abnormal_white_adipose0.72141150
142MP0001270_distended_abdomen0.71843290

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)2.92067512
2Abnormality of the labia minora (HP:0012880)2.89417293
3Facial hemangioma (HP:0000329)2.77301783
4Shallow orbits (HP:0000586)2.67356555
5Turricephaly (HP:0000262)2.66774900
6Patellar aplasia (HP:0006443)2.65051576
7Protrusio acetabuli (HP:0003179)2.61819604
8Mutism (HP:0002300)2.61077877
9Aplasia/Hypoplasia of the patella (HP:0006498)2.57242803
10Broad distal phalanx of finger (HP:0009836)2.51967274
11Shawl scrotum (HP:0000049)2.43293407
12Abnormality of the phalanges of the hallux (HP:0010057)2.39870563
13Shoulder girdle muscle weakness (HP:0003547)2.34795851
14Abnormality of the distal phalanx of the thumb (HP:0009617)2.31022112
15Bronchomalacia (HP:0002780)2.23000434
16Obstructive sleep apnea (HP:0002870)2.22978739
17Hyperacusis (HP:0010780)2.22464496
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21573547
19Short 4th metacarpal (HP:0010044)2.21573547
20Partial duplication of the phalanx of hand (HP:0009999)2.20406952
21Renal duplication (HP:0000075)2.18823561
22Atrophic scars (HP:0001075)2.18462908
23Partial duplication of thumb phalanx (HP:0009944)2.17295717
24Coronal craniosynostosis (HP:0004440)2.15792778
25Pelvic girdle muscle weakness (HP:0003749)2.13537693
26Morphological abnormality of the middle ear (HP:0008609)2.09778874
27Breast hypoplasia (HP:0003187)2.09106510
28Aplasia involving bones of the extremities (HP:0009825)2.08232002
29Aplasia involving bones of the upper limbs (HP:0009823)2.08232002
30Aplasia of the phalanges of the hand (HP:0009802)2.08232002
31Bladder diverticulum (HP:0000015)2.07604867
32Fetal akinesia sequence (HP:0001989)2.07329018
33Rib fusion (HP:0000902)2.07216574
34Broad metatarsal (HP:0001783)2.06773113
35Fragile skin (HP:0001030)2.02730577
36Abnormality of the aortic arch (HP:0012303)2.00744996
37Broad face (HP:0000283)1.99405049
38Wrist flexion contracture (HP:0001239)1.98295963
39Pointed chin (HP:0000307)1.97093216
40Annular pancreas (HP:0001734)1.96381120
41Bowing of the arm (HP:0006488)1.96325689
42Bowed forearm bones (HP:0003956)1.96325689
43Abnormality of the hip-girdle musculature (HP:0001445)1.91790167
44Abnormality of the musculature of the pelvis (HP:0001469)1.91790167
45Long palpebral fissure (HP:0000637)1.91743258
46Disproportionate tall stature (HP:0001519)1.89535126
47Deviation of the hallux (HP:0010051)1.89189746
48Overriding aorta (HP:0002623)1.88757654
49Neonatal short-limb short stature (HP:0008921)1.88367331
50Broad phalanges of the hand (HP:0009768)1.85905103
51Male infertility (HP:0003251)1.85687440
52Mitral regurgitation (HP:0001653)1.85134576
53Thin ribs (HP:0000883)1.84918406
54Genetic anticipation (HP:0003743)1.83840025
55Aplasia involving forearm bones (HP:0009822)1.81407330
56Absent forearm bone (HP:0003953)1.81407330
57Absent radius (HP:0003974)1.81211093
58Cutaneous finger syndactyly (HP:0010554)1.80628455
59Broad finger (HP:0001500)1.80312403
60Trigonocephaly (HP:0000243)1.80189518
61Astrocytoma (HP:0009592)1.79630758
62Abnormality of the astrocytes (HP:0100707)1.79630758
63Oligodactyly (HP:0012165)1.79172384
64Cutaneous syndactyly (HP:0012725)1.78994484
65Birth length less than 3rd percentile (HP:0003561)1.78977364
66Hallux valgus (HP:0001822)1.76860816
67Hypoventilation (HP:0002791)1.76751021
68Increased nuchal translucency (HP:0010880)1.76557509
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.75246350
70Cerebral aneurysm (HP:0004944)1.72627075
71Concave nail (HP:0001598)1.72256674
72Apathy (HP:0000741)1.71659882
73Spina bifida occulta (HP:0003298)1.70981369
74Deep palmar crease (HP:0006191)1.69562472
75Abnormality of the 4th metacarpal (HP:0010012)1.68413845
76Broad long bones (HP:0005622)1.67645408
77Oligodactyly (hands) (HP:0001180)1.66266453
78Elfin facies (HP:0004428)1.66170274
79Broad phalanx (HP:0006009)1.65617063
80Patellar dislocation (HP:0002999)1.65175812
81Transposition of the great arteries (HP:0001669)1.64265260
82Abnormal connection of the cardiac segments (HP:0011545)1.64265260
83Abnormal ventriculo-arterial connection (HP:0011563)1.64265260
84Flat cornea (HP:0007720)1.64005482
85Long eyelashes (HP:0000527)1.63765517
86Myokymia (HP:0002411)1.63338782
87Abnormality of dentin (HP:0010299)1.62991669
88Selective tooth agenesis (HP:0001592)1.62939748
89Abnormality of the calcaneus (HP:0008364)1.62331137
90Laryngomalacia (HP:0001601)1.61783236
91Chin dimple (HP:0010751)1.61782950
92Carpal synostosis (HP:0009702)1.60813927
93Wide anterior fontanel (HP:0000260)1.60667003
94Excessive salivation (HP:0003781)1.59389062
95Drooling (HP:0002307)1.59389062
96Precocious puberty (HP:0000826)1.58214911
97Spinal rigidity (HP:0003306)1.57512187
98Biconcave vertebral bodies (HP:0004586)1.57062952
99Abnormality of the diencephalon (HP:0010662)1.56877807
100Achilles tendon contracture (HP:0001771)1.56240087
101Sacral dimple (HP:0000960)1.54832500
102Limb dystonia (HP:0002451)1.54747684
103Arnold-Chiari malformation (HP:0002308)1.54054205
104Esophageal atresia (HP:0002032)1.53296266
105Leiomyosarcoma (HP:0100243)1.53200215
106Uterine leiomyosarcoma (HP:0002891)1.53200215
107Aqueductal stenosis (HP:0002410)1.52989008
108Distal upper limb amyotrophy (HP:0007149)1.52928560
109Upper limb amyotrophy (HP:0009129)1.52928560
110Hyperextensible skin (HP:0000974)1.52911551
111Vesicoureteral reflux (HP:0000076)1.52615300
112Abnormality of the intervertebral disk (HP:0005108)1.52577489
113Amyotrophic lateral sclerosis (HP:0007354)1.52118742
114Broad-based gait (HP:0002136)1.51974806
115Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.51868188
116Short 1st metacarpal (HP:0010034)1.51868188
117Diminished motivation (HP:0000745)1.51193140
118Breast aplasia (HP:0100783)1.51107854
119Natal tooth (HP:0000695)1.50757401
120Lower limb amyotrophy (HP:0007210)1.50179153
121Abnormality of chromosome segregation (HP:0002916)1.50133721
122Aplasia/Hypoplasia of the breasts (HP:0010311)1.49837474
123Atresia of the external auditory canal (HP:0000413)1.49614215
124Genu recurvatum (HP:0002816)1.49374643
125Focal motor seizures (HP:0011153)1.49124885
126Bowel diverticulosis (HP:0005222)1.49007031
127Insomnia (HP:0100785)1.48427292
128Glossoptosis (HP:0000162)1.47290856
129Megalocornea (HP:0000485)1.47192360
130Preauricular skin tag (HP:0000384)1.47007297
131Dysmetric saccades (HP:0000641)1.46635307
132Duplication of thumb phalanx (HP:0009942)1.46633141
133Obsessive-compulsive behavior (HP:0000722)1.46628627
134Renal dysplasia (HP:0000110)1.46204553
135Pterygium (HP:0001059)1.46079040
136Supernumerary ribs (HP:0005815)1.45621916
137Broad hallux (HP:0010055)1.45431900
138Focal seizures (HP:0007359)1.45186552
139Broad alveolar ridges (HP:0000187)1.45178361
140Renovascular hypertension (HP:0100817)1.45013236
141Abnormality of the middle phalanges of the toes (HP:0010183)1.44523951
142Absent septum pellucidum (HP:0001331)1.42793781
143Inappropriate behavior (HP:0000719)1.42391605
144High anterior hairline (HP:0009890)1.41897125
145Vertebral arch anomaly (HP:0008438)1.41792321
146Ventricular fibrillation (HP:0001663)1.41639893
147Midline defect of the nose (HP:0004122)1.41589821
148Heterotopia (HP:0002282)1.41331616
149Glioma (HP:0009733)1.40978767
150Capillary hemangiomas (HP:0005306)1.40888771
151Truncus arteriosus (HP:0001660)1.40489419
152Premature rupture of membranes (HP:0001788)1.40260412
153Broad thumb (HP:0011304)1.40049627
154Difficulty climbing stairs (HP:0003551)1.39924398
155Increased number of teeth (HP:0011069)1.39850174
156Enlarged penis (HP:0000040)1.39505964
157Abnormality of the septum pellucidum (HP:0007375)1.38382217
158Ependymoma (HP:0002888)1.37382468
159Abnormality of the shoulder girdle musculature (HP:0001435)1.36877120
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.36366788
161Sparse lateral eyebrow (HP:0005338)1.34907232
162Aplasia/hypoplasia of the humerus (HP:0006507)1.33976318
163Volvulus (HP:0002580)1.33398311
164Exotropia (HP:0000577)1.33117082
165Transitional cell carcinoma of the bladder (HP:0006740)1.33101938
166Supernumerary spleens (HP:0009799)1.32761605
167Calcaneovalgus deformity (HP:0001848)1.32508571
168Abnormal number of incisors (HP:0011064)1.32367749
169Sporadic (HP:0003745)1.32019566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.29829204
2LATS23.68058138
3MAP3K93.16625919
4MAP3K62.48865785
5NTRK12.37736857
6SMG12.30280724
7DYRK22.21584594
8TYRO32.04133992
9BUB11.99832947
10SIK11.97529454
11PAK61.93632182
12LATS11.91910232
13MAPK131.90475966
14ICK1.87091347
15SIK21.78967889
16NTRK21.76644099
17PNCK1.72276696
18TAOK11.69296625
19EPHA21.68082299
20RIPK11.67979254
21KSR11.66553072
22MAP3K41.60147873
23EEF2K1.55875611
24PKN21.51249506
25EPHB21.49311648
26CAMK1D1.48658353
27NEK21.48121615
28TTK1.46009816
29MAPK151.42631765
30DDR21.42141353
31CASK1.31141650
32PRKD31.25907776
33MOS1.24399878
34KSR21.24239247
35ALK1.22720877
36DMPK1.20121532
37CDC71.17482542
38TSSK61.15335640
39CHEK21.12954995
40NTRK31.12031972
41MKNK21.11582026
42EPHA41.11219151
43UHMK11.10311501
44ARAF1.09741806
45DYRK31.08022145
46MET1.07875004
47WEE11.06163261
48MARK21.05355936
49PLK41.04355194
50PDGFRA1.04038397
51ERBB31.03198009
52FGR1.00775075
53PAK40.99995893
54PLK30.99667624
55NEK10.99402711
56PLK10.98770764
57MKNK10.98471960
58CDK80.97675041
59PHKG10.96053566
60PHKG20.96053566
61STK38L0.94125534
62BRAF0.94075843
63BRD40.94074428
64SRPK10.93018342
65STK110.93013526
66STK380.92415349
67MINK10.89279629
68CDK150.88104749
69FGFR20.83269321
70CDK180.83071456
71CDK11A0.81899362
72CDK140.80330165
73BRSK10.80178955
74MAP2K70.79967840
75PIM20.77960155
76IRAK30.77199675
77STK30.76818311
78PRKD20.76506520
79AKT30.75461475
80RAF10.75447068
81TTN0.74633006
82CDK70.73151286
83RPS6KL10.70569718
84RPS6KC10.70569718
85CDK30.67870197
86PAK20.67727571
87MTOR0.66352260
88SGK4940.65203540
89SGK2230.65203540
90RPS6KA60.65091779
91PTK60.64820943
92TRIB30.64786487
93CAMKK10.62750493
94CDK50.61110565
95MST1R0.60534175
96AURKA0.59899191
97CDK20.58603142
98LMTK20.58548425
99CHEK10.57371989
100FGFR40.56644314
101RPS6KA10.53604334
102AKT20.53207159
103PDGFRB0.51374046
104PRKCI0.51233127
105NME20.50953712
106CDK10.50442316
107PRKCH0.49612614
108PLK20.48949766
109SGK30.48783394
110ILK0.48148493
111PAK30.47550552
112MAPK90.46707704
113BMX0.46381515
114* CSNK1E0.45924182
115CCNB10.45404116
116RPS6KB20.44952589
117LIMK10.44659183
118CDK120.44494021
119MAPK100.42273831
120MAP3K70.41830554
121CDC42BPA0.41072290
122MAP2K20.41015770
123RPS6KA20.40680306
124DYRK1B0.40573171
125CDK90.40429736
126PKN10.40197333
127FER0.40112720
128DYRK1A0.40043571
129MAP3K100.40014097
130CAMK1G0.39744933
131ERBB20.39241306
132RET0.38907644
133GSK3B0.38644615
134PRPF4B0.38519291
135AKT10.37905598
136HIPK20.37515523
137* MAPK140.37107333
138PTK20.36934591
139MAPK80.36252110

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041101.82210788
2Oocyte meiosis_Homo sapiens_hsa041141.78047421
3Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68256306
4Axon guidance_Homo sapiens_hsa043601.67615785
5* Hippo signaling pathway_Homo sapiens_hsa043901.63422336
6ECM-receptor interaction_Homo sapiens_hsa045121.57297831
7Colorectal cancer_Homo sapiens_hsa052101.55234723
8Nicotine addiction_Homo sapiens_hsa050331.54153682
9mRNA surveillance pathway_Homo sapiens_hsa030151.48701039
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45851863
11RNA transport_Homo sapiens_hsa030131.45333454
12Basal cell carcinoma_Homo sapiens_hsa052171.43308406
13Renal cell carcinoma_Homo sapiens_hsa052111.35557876
14MicroRNAs in cancer_Homo sapiens_hsa052061.33777692
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.31912289
16Spliceosome_Homo sapiens_hsa030401.31054653
17mTOR signaling pathway_Homo sapiens_hsa041501.30029394
18Gap junction_Homo sapiens_hsa045401.29214508
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28884182
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28446019
21Lysine degradation_Homo sapiens_hsa003101.28271997
22Sulfur relay system_Homo sapiens_hsa041221.28242392
23GnRH signaling pathway_Homo sapiens_hsa049121.27584892
24Notch signaling pathway_Homo sapiens_hsa043301.27051476
25Endometrial cancer_Homo sapiens_hsa052131.26318813
26* Wnt signaling pathway_Homo sapiens_hsa043101.26016110
27* Hedgehog signaling pathway_Homo sapiens_hsa043401.24966971
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24478532
29ErbB signaling pathway_Homo sapiens_hsa040121.20974686
30Prion diseases_Homo sapiens_hsa050201.20465396
31Glutamatergic synapse_Homo sapiens_hsa047241.17433462
32Estrogen signaling pathway_Homo sapiens_hsa049151.16498958
33Glioma_Homo sapiens_hsa052141.15110780
34Adherens junction_Homo sapiens_hsa045201.14958982
35Long-term depression_Homo sapiens_hsa047301.14692634
36Thyroid cancer_Homo sapiens_hsa052161.13304169
37Long-term potentiation_Homo sapiens_hsa047201.13084321
38Dorso-ventral axis formation_Homo sapiens_hsa043201.10284671
39TGF-beta signaling pathway_Homo sapiens_hsa043501.10242531
40Dopaminergic synapse_Homo sapiens_hsa047281.08406685
41RNA polymerase_Homo sapiens_hsa030201.07836382
42Melanogenesis_Homo sapiens_hsa049161.07247249
43p53 signaling pathway_Homo sapiens_hsa041151.05424935
44VEGF signaling pathway_Homo sapiens_hsa043701.05307203
45Oxytocin signaling pathway_Homo sapiens_hsa049211.05038816
46Tight junction_Homo sapiens_hsa045301.03792174
47Basal transcription factors_Homo sapiens_hsa030221.03667714
48AMPK signaling pathway_Homo sapiens_hsa041521.03584803
49Circadian entrainment_Homo sapiens_hsa047131.03294667
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02638403
51Synaptic vesicle cycle_Homo sapiens_hsa047211.02499970
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02308954
53Chronic myeloid leukemia_Homo sapiens_hsa052201.02034324
54Olfactory transduction_Homo sapiens_hsa047401.01392741
55Vitamin B6 metabolism_Homo sapiens_hsa007501.00815745
56Choline metabolism in cancer_Homo sapiens_hsa052311.00695614
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00528760
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98408903
59MAPK signaling pathway_Homo sapiens_hsa040100.97180330
60Insulin signaling pathway_Homo sapiens_hsa049100.96504417
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95342379
62Amphetamine addiction_Homo sapiens_hsa050310.94971765
63Prostate cancer_Homo sapiens_hsa052150.94029869
64Dilated cardiomyopathy_Homo sapiens_hsa054140.93513790
65Cholinergic synapse_Homo sapiens_hsa047250.93091435
66Morphine addiction_Homo sapiens_hsa050320.92410453
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91192863
68Rap1 signaling pathway_Homo sapiens_hsa040150.90109588
69GABAergic synapse_Homo sapiens_hsa047270.89702842
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88713957
71Serotonergic synapse_Homo sapiens_hsa047260.87961697
72Pancreatic cancer_Homo sapiens_hsa052120.87622948
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85284221
74Cocaine addiction_Homo sapiens_hsa050300.85200525
75Insulin secretion_Homo sapiens_hsa049110.84915358
76Ras signaling pathway_Homo sapiens_hsa040140.84581356
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.83560391
78Ribosome_Homo sapiens_hsa030100.83100548
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.82546278
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82210239
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81950270
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81791069
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81349307
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81159014
85Non-small cell lung cancer_Homo sapiens_hsa052230.80923467
86Base excision repair_Homo sapiens_hsa034100.80849600
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80058218
88Pathways in cancer_Homo sapiens_hsa052000.79471729
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78454829
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78423500
91Melanoma_Homo sapiens_hsa052180.78151136
92Proteoglycans in cancer_Homo sapiens_hsa052050.77694665
93Focal adhesion_Homo sapiens_hsa045100.76484165
94Ovarian steroidogenesis_Homo sapiens_hsa049130.75827989
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75090905
96* Circadian rhythm_Homo sapiens_hsa047100.74186263
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73963932
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73805615
99Bladder cancer_Homo sapiens_hsa052190.72814855
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72756477
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.72410064
102Biosynthesis of amino acids_Homo sapiens_hsa012300.72205580
103HTLV-I infection_Homo sapiens_hsa051660.71418739
104Small cell lung cancer_Homo sapiens_hsa052220.71287643
105* FoxO signaling pathway_Homo sapiens_hsa040680.69941041
106Taste transduction_Homo sapiens_hsa047420.69107605
107Endocytosis_Homo sapiens_hsa041440.68865043
108Glucagon signaling pathway_Homo sapiens_hsa049220.67503204
109RNA degradation_Homo sapiens_hsa030180.67141023
110Fanconi anemia pathway_Homo sapiens_hsa034600.66650265
111cAMP signaling pathway_Homo sapiens_hsa040240.66318355
112Nucleotide excision repair_Homo sapiens_hsa034200.65873247
113Thyroid hormone synthesis_Homo sapiens_hsa049180.65193887
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65173121
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64828602
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64618453
117Viral myocarditis_Homo sapiens_hsa054160.64563722
118Salivary secretion_Homo sapiens_hsa049700.64208677
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63980522
120Mismatch repair_Homo sapiens_hsa034300.63495678
121Protein digestion and absorption_Homo sapiens_hsa049740.63088858
122Gastric acid secretion_Homo sapiens_hsa049710.62335405
123Vibrio cholerae infection_Homo sapiens_hsa051100.60703179
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60585039
125DNA replication_Homo sapiens_hsa030300.55172971
126Alcoholism_Homo sapiens_hsa050340.55164662
127Acute myeloid leukemia_Homo sapiens_hsa052210.54146818

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