CSNK1G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of spindle organization (GO:0090224)6.89381780
2ribosome assembly (GO:0042255)6.81330071
3inner cell mass cell proliferation (GO:0001833)6.05563658
4multicellular organism reproduction (GO:0032504)4.73417929
5positive regulation of catecholamine secretion (GO:0033605)4.60066377
6regulation of acrosome reaction (GO:0060046)4.54872552
7cerebellar Purkinje cell differentiation (GO:0021702)4.51242768
8regulation of phosphoprotein phosphatase activity (GO:0043666)4.31612383
9male meiosis (GO:0007140)4.25278100
10mRNA cleavage (GO:0006379)4.05205040
11negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.03384608
12cilium or flagellum-dependent cell motility (GO:0001539)4.02285671
13centriole replication (GO:0007099)3.90517923
14centriole assembly (GO:0098534)3.86851852
15epithelial cilium movement (GO:0003351)3.85827736
16cytoplasmic mRNA processing body assembly (GO:0033962)3.82090210
17regulation of NFAT protein import into nucleus (GO:0051532)3.73531930
18binding of sperm to zona pellucida (GO:0007339)3.69394130
19motile cilium assembly (GO:0044458)3.57256491
20acrosome reaction (GO:0007340)3.55752910
21ventricular system development (GO:0021591)3.54215222
22negative regulation of microtubule depolymerization (GO:0007026)3.53250903
23sperm motility (GO:0030317)3.52797411
24DNA double-strand break processing (GO:0000729)3.48374723
25ribosomal large subunit biogenesis (GO:0042273)3.47103479
26tongue development (GO:0043586)3.46305989
27axonemal dynein complex assembly (GO:0070286)3.46054815
28establishment of protein localization to Golgi (GO:0072600)3.42451364
29regulation of retinoic acid receptor signaling pathway (GO:0048385)3.41948832
30cilium movement (GO:0003341)3.39003602
31retinal cone cell development (GO:0046549)3.37903807
32acrosome assembly (GO:0001675)3.36434181
33spermatid development (GO:0007286)3.33666245
34sperm-egg recognition (GO:0035036)3.32663476
35TOR signaling (GO:0031929)3.28727927
36regulation of microtubule depolymerization (GO:0031114)3.22422748
37meiotic chromosome segregation (GO:0045132)3.19712421
38protein targeting to Golgi (GO:0000042)3.13769478
39regulation of hippo signaling (GO:0035330)3.09909502
40positive regulation of cardiac muscle cell differentiation (GO:2000727)3.09401415
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08878973
42protein K11-linked deubiquitination (GO:0035871)3.07311714
43histone H3-K9 methylation (GO:0051567)3.05016575
44reproduction (GO:0000003)3.01546867
45cell-cell recognition (GO:0009988)3.00530692
46retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98968115
47N-terminal protein amino acid acetylation (GO:0006474)2.96414048
48plasma membrane repair (GO:0001778)2.96234800
49nuclear pore complex assembly (GO:0051292)2.94844936
50negative regulation of dendrite development (GO:2000171)2.86772050
51monoubiquitinated protein deubiquitination (GO:0035520)2.85331433
52regulation of centrosome duplication (GO:0010824)2.84198394
53regulation of centriole replication (GO:0046599)2.83411828
54neuron projection extension involved in neuron projection guidance (GO:1902284)2.81073687
55axon extension involved in axon guidance (GO:0048846)2.81073687
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80261402
57positive regulation of developmental pigmentation (GO:0048087)2.78171720
58regulation of keratinocyte proliferation (GO:0010837)2.77254177
59peptidyl-lysine methylation (GO:0018022)2.76957163
60regulation of vacuole organization (GO:0044088)2.76429702
61genitalia morphogenesis (GO:0035112)2.76074286
62histone H3-K4 trimethylation (GO:0080182)2.75738681
63mitotic chromosome condensation (GO:0007076)2.75679067
64protein K63-linked deubiquitination (GO:0070536)2.75672664
65histone lysine demethylation (GO:0070076)2.75622969
66peptidyl-lysine dimethylation (GO:0018027)2.73924880
67regulation of DNA endoreduplication (GO:0032875)2.73753482
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.73425931
69regulation of translation, ncRNA-mediated (GO:0045974)2.73425931
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73425931
71histone demethylation (GO:0016577)2.71045732
72protein K48-linked deubiquitination (GO:0071108)2.68974727
73regulation of oxidative stress-induced neuron death (GO:1903203)2.68312503
74membrane depolarization during action potential (GO:0086010)2.67595100
75histone H3-K9 demethylation (GO:0033169)2.66595693
76sister chromatid cohesion (GO:0007062)2.62898658
77regulation of autophagic vacuole assembly (GO:2000785)2.62408437
78negative regulation of keratinocyte proliferation (GO:0010839)2.61346314
79microtubule nucleation (GO:0007020)2.61182083
80histone mRNA catabolic process (GO:0071044)2.61099131
81retinal ganglion cell axon guidance (GO:0031290)2.60228343
82microtubule depolymerization (GO:0007019)2.60227987
83gene silencing by RNA (GO:0031047)2.60001886
84protein dealkylation (GO:0008214)2.59671444
85protein demethylation (GO:0006482)2.59671444
86regulation of RNA export from nucleus (GO:0046831)2.58074210
87ectoderm development (GO:0007398)2.57724538
88negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.57437233
89pore complex assembly (GO:0046931)2.55869584
90nuclear pore organization (GO:0006999)2.55454068
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55165755
92radial glial cell differentiation (GO:0060019)2.55095822
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50509338
94protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49973685
95spermatid nucleus differentiation (GO:0007289)2.49918817
96rRNA methylation (GO:0031167)2.49456711
97glomerular visceral epithelial cell development (GO:0072015)2.49059596
98regulation of centrosome cycle (GO:0046605)2.48784415
99response to pheromone (GO:0019236)2.48714795
100single fertilization (GO:0007338)2.45973013
101regulation of establishment of cell polarity (GO:2000114)2.45811350
102synapsis (GO:0007129)2.45737950
103peripheral nervous system neuron development (GO:0048935)2.45446156
104cilium organization (GO:0044782)2.44893234
105fibroblast migration (GO:0010761)2.43744247
106DNA synthesis involved in DNA repair (GO:0000731)2.43191494
107androgen receptor signaling pathway (GO:0030521)2.42376091
108UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42234480
109regulation of short-term neuronal synaptic plasticity (GO:0048172)2.41056179
110cilium assembly (GO:0042384)2.40897480
111histone H3-K9 modification (GO:0061647)2.39677250
112regulation of transforming growth factor beta2 production (GO:0032909)2.39563207
113histone H3-K36 demethylation (GO:0070544)2.37501333
114microtubule anchoring (GO:0034453)2.34902207
115hemidesmosome assembly (GO:0031581)2.34127305
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.33418515
117oocyte development (GO:0048599)2.32576669
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32281707
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.32013197
120cell differentiation in hindbrain (GO:0021533)2.31630893
121protein localization to cilium (GO:0061512)2.29334755
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.28668689
123eye photoreceptor cell development (GO:0042462)2.28643043
124negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.27780577
125glutamate secretion (GO:0014047)2.24688591
126behavioral response to pain (GO:0048266)2.24604218
127protein localization to synapse (GO:0035418)2.15477408
128regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.15160887
129photoreceptor cell development (GO:0042461)2.14627871
130regulation of synaptic vesicle exocytosis (GO:2000300)2.12010946
131negative regulation of dendrite morphogenesis (GO:0050774)2.10076568
132negative regulation of meiosis (GO:0045835)2.09051481
133membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.07896661
134retinal rod cell development (GO:0046548)2.05997006
135mitotic sister chromatid cohesion (GO:0007064)2.04780736
136DNA damage induced protein phosphorylation (GO:0006975)2.04092932
137detection of light stimulus involved in sensory perception (GO:0050962)2.03481349
138detection of light stimulus involved in visual perception (GO:0050908)2.03481349
139ganglion development (GO:0061548)2.03412700
140G-protein coupled receptor internalization (GO:0002031)2.03207583
141positive regulation of muscle hypertrophy (GO:0014742)2.03145458
142positive regulation of cardiac muscle hypertrophy (GO:0010613)2.03145458
143neurofilament cytoskeleton organization (GO:0060052)2.01745546
144sequestering of extracellular ligand from receptor (GO:0035581)2.01297227
145synaptic vesicle endocytosis (GO:0048488)2.00430041
146regulation of neurotransmitter secretion (GO:0046928)2.00294034
147negative T cell selection (GO:0043383)2.00200543
148regulation of mitotic spindle organization (GO:0060236)10.3503774
149modulation by virus of host process (GO:0019054)1.98749170
150rhodopsin mediated signaling pathway (GO:0016056)1.97870982
151establishment of nucleus localization (GO:0040023)1.97410932
152neuronal action potential (GO:0019228)1.96618708
153histone H3-K4 methylation (GO:0051568)1.96455711
154dendritic cell chemotaxis (GO:0002407)1.95233762
155negative regulation of protein depolymerization (GO:1901880)1.93137404
156CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.92958290
157T-helper cell differentiation (GO:0042093)1.92958290
158regulation of mitotic spindle checkpoint (GO:1903504)1.91890116
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.91890116
160regulation of rhodopsin mediated signaling pathway (GO:0022400)1.91816542
161dentate gyrus development (GO:0021542)1.90344700
162positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.90231875
163myoblast fusion (GO:0007520)1.90061197
164CD4-positive, alpha-beta T cell differentiation (GO:0043367)1.89619102
165negative thymic T cell selection (GO:0045060)1.89345042
166protein localization to microtubule cytoskeleton (GO:0072698)1.88867362
167regulation of Rac GTPase activity (GO:0032314)1.87626226
168negative chemotaxis (GO:0050919)1.86590349
169synaptic transmission, glutamatergic (GO:0035249)1.86084204
170striatum development (GO:0021756)1.85363796
171synaptic vesicle maturation (GO:0016188)1.85280373
172modulation by symbiont of host cellular process (GO:0044068)1.83232428
173axonal fasciculation (GO:0007413)1.82944684
174axon extension (GO:0048675)1.82896162
175regulation of meiosis I (GO:0060631)1.82800177
176positive regulation of mitotic metaphase/anaphase transition (GO:0045842)1.82123442
177positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.82123442
178positive regulation of mitotic sister chromatid separation (GO:1901970)1.82123442
179serotonin receptor signaling pathway (GO:0007210)1.81054632
180negative regulation of homotypic cell-cell adhesion (GO:0034111)1.80732374
181regulation of synaptic vesicle transport (GO:1902803)1.80558944
182phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.80297118
183photoreceptor cell maintenance (GO:0045494)1.80048305
184peptidyl-lysine trimethylation (GO:0018023)1.79749203
185forebrain morphogenesis (GO:0048853)1.79691119
186innervation (GO:0060384)1.79635802
187syncytium formation by plasma membrane fusion (GO:0000768)1.78836125
188positive regulation of DNA recombination (GO:0045911)1.78405260
189negative regulation of DNA-dependent DNA replication (GO:2000104)1.76841041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.09330723
2GBX2_23144817_ChIP-Seq_PC3_Human3.98668202
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.45804530
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.81526309
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73988410
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.66780961
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57887777
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55222174
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.53564446
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47592015
11* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.47271369
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38965630
13EZH2_22144423_ChIP-Seq_EOC_Human2.38385039
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30692178
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30661959
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18505514
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17128823
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15608818
19SMAD4_21799915_ChIP-Seq_A2780_Human1.93973783
20P300_19829295_ChIP-Seq_ESCs_Human1.93669953
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.89255295
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.87435094
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79656598
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75149028
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.72282171
26CBP_20019798_ChIP-Seq_JUKART_Human1.70599305
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70599305
28STAT3_23295773_ChIP-Seq_U87_Human1.69031210
29BRD4_25478319_ChIP-Seq_HGPS_Human1.63117846
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62227209
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61209864
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59902949
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58715819
34* TCF4_23295773_ChIP-Seq_U87_Human1.56756587
35CJUN_26792858_Chip-Seq_BT549_Human1.56225227
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54312319
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.53809013
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52914321
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52541850
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52199797
41RNF2_27304074_Chip-Seq_NSC_Mouse1.51850734
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51753148
43TAF15_26573619_Chip-Seq_HEK293_Human1.51416838
44EWS_26573619_Chip-Seq_HEK293_Human1.51177753
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.49097850
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45477271
47BCAT_22108803_ChIP-Seq_LS180_Human1.42741804
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.41707000
49RXR_22108803_ChIP-Seq_LS180_Human1.38907220
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.38683972
51IGF1R_20145208_ChIP-Seq_DFB_Human1.37737598
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36786691
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36591307
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36481220
55FUS_26573619_Chip-Seq_HEK293_Human1.36271394
56YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35363010
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.34060233
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32891221
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32770543
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30878234
61TP53_16413492_ChIP-PET_HCT116_Human1.30721037
62TP53_18474530_ChIP-ChIP_U2OS_Human1.30334532
63TP63_23658742_ChIP-Seq_EP156T_Human1.29736971
64CDX2_22108803_ChIP-Seq_LS180_Human1.29176343
65AHR_22903824_ChIP-Seq_MCF-7_Human1.28994836
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.28342478
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.27728040
68AR_25329375_ChIP-Seq_VCAP_Human1.27282367
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.26944018
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26641912
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26482256
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26354158
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26196286
74P53_22387025_ChIP-Seq_ESCs_Mouse1.25048698
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20808008
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20765965
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20629252
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20216110
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20178212
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19851031
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19828084
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19443988
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.18633279
84JUN_21703547_ChIP-Seq_K562_Human1.18503442
85DROSHA_22980978_ChIP-Seq_HELA_Human1.18291074
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17802575
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17320945
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.17140499
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16997731
90GATA1_22025678_ChIP-Seq_K562_Human1.16935068
91AR_21572438_ChIP-Seq_LNCaP_Human1.16743527
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15544389
93IRF1_19129219_ChIP-ChIP_H3396_Human1.15160292
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.14836062
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.14446990
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.13953385
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13188066
98ELK1_19687146_ChIP-ChIP_HELA_Human1.12862348
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12274199
100VDR_24787735_ChIP-Seq_THP-1_Human1.12176215
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.11956297
102SOX9_26525672_Chip-Seq_HEART_Mouse1.11536073
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11160696
104RUNX2_22187159_ChIP-Seq_PCA_Human1.10763137
105P300_18555785_Chip-Seq_ESCs_Mouse1.08354503
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.07942721
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07478971
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.07344954
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07011949
110AR_21909140_ChIP-Seq_LNCAP_Human1.06616986
111TBL1_22424771_ChIP-Seq_293T_Human1.06470964
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06095697
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06095697
114VDR_22108803_ChIP-Seq_LS180_Human1.05870681
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05822243
116EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05822243
117E2F7_22180533_ChIP-Seq_HELA_Human1.04948444
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04659520
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.04295841
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02921921
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02921921
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02699992
123NFE2_27457419_Chip-Seq_LIVER_Mouse1.01543945
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01339401
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01334435
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00317032
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00114898
128* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98676576
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98458298
130ELF5_23300383_ChIP-Seq_T47D_Human0.98120191
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98055994
132OCT4_18555785_Chip-Seq_ESCs_Mouse0.97984506
133ER_23166858_ChIP-Seq_MCF-7_Human0.97952555
134REST_21632747_ChIP-Seq_MESCs_Mouse0.97313467
135AR_19668381_ChIP-Seq_PC3_Human0.97264016
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97248499
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96956677
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95602862
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95525489
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94977600
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94889741
142MYB_26560356_Chip-Seq_TH1_Human0.94450120
143IRF8_21731497_ChIP-ChIP_J774_Mouse0.93783250
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92620324
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91504603
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91394298
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90310708
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.88822276
149GATA3_26560356_Chip-Seq_TH2_Human0.88473848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.59808946
2MP0000569_abnormal_digit_pigmentation4.27799577
3MP0005410_abnormal_fertilization3.56655221
4MP0003787_abnormal_imprinting3.29029835
5MP0002127_abnormal_cardiovascular_syste2.84221390
6MP0008877_abnormal_DNA_methylation2.76252145
7MP0005248_abnormal_Harderian_gland2.65067879
8MP0001986_abnormal_taste_sensitivity2.52831179
9MP0002009_preneoplasia2.52095821
10MP0004381_abnormal_hair_follicle2.31851362
11MP0010678_abnormal_skin_adnexa2.28442622
12MP0005409_darkened_coat_color2.23324361
13MP0001348_abnormal_lacrimal_gland2.21505801
14MP0002735_abnormal_chemical_nociception2.15768513
15MP0003121_genomic_imprinting2.13949154
16MP0008004_abnormal_stomach_pH2.13186533
17MP0001984_abnormal_olfaction2.08411883
18MP0000383_abnormal_hair_follicle2.04366697
19MP0000427_abnormal_hair_cycle1.88113921
20MP0003136_yellow_coat_color1.83576136
21MP0005645_abnormal_hypothalamus_physiol1.81485298
22MP0005367_renal/urinary_system_phenotyp1.79090002
23MP0000516_abnormal_urinary_system1.79090002
24MP0003941_abnormal_skin_development1.77856376
25MP0010234_abnormal_vibrissa_follicle1.75415376
26MP0004859_abnormal_synaptic_plasticity1.74856712
27MP0003950_abnormal_plasma_membrane1.73196294
28MP0004858_abnormal_nervous_system1.72924238
29MP0001188_hyperpigmentation1.71564713
30MP0001929_abnormal_gametogenesis1.70781933
31MP0003718_maternal_effect1.69707347
32MP0005423_abnormal_somatic_nervous1.69453234
33MP0003077_abnormal_cell_cycle1.61424846
34MP0009697_abnormal_copulation1.59455753
35MP0003122_maternal_imprinting1.58790211
36MP0002163_abnormal_gland_morphology1.58429206
37MP0000371_diluted_coat_color1.57741779
38MP0003183_abnormal_peptide_metabolism1.52194193
39MP0005083_abnormal_biliary_tract1.47397621
40MP0009046_muscle_twitch1.46107386
41MP0005394_taste/olfaction_phenotype1.45853154
42MP0005499_abnormal_olfactory_system1.45853154
43MP0000778_abnormal_nervous_system1.41177122
44MP0003698_abnormal_male_reproductive1.40884628
45MP0005551_abnormal_eye_electrophysiolog1.39545864
46MP0005451_abnormal_body_composition1.39267709
47MP0003763_abnormal_thymus_physiology1.38757658
48MP0003635_abnormal_synaptic_transmissio1.36114575
49MP0000015_abnormal_ear_pigmentation1.35811503
50MP0002184_abnormal_innervation1.35653724
51MP0001919_abnormal_reproductive_system1.34384388
52MP0010386_abnormal_urinary_bladder1.32094502
53MP0002638_abnormal_pupillary_reflex1.31206494
54MP0005671_abnormal_response_to1.27598133
55MP0003936_abnormal_reproductive_system1.27071837
56MP0004233_abnormal_muscle_weight1.26128772
57MP0005389_reproductive_system_phenotype1.25209594
58MP0000627_abnormal_mammary_gland1.25043352
59MP0002095_abnormal_skin_pigmentation1.25040918
60MP0006072_abnormal_retinal_apoptosis1.23951611
61MP0003880_abnormal_central_pattern1.22725791
62MP0008007_abnormal_cellular_replicative1.22138170
63MP0002063_abnormal_learning/memory/cond1.21848788
64MP0000538_abnormal_urinary_bladder1.20546484
65MP0002233_abnormal_nose_morphology1.16018595
66MP0006276_abnormal_autonomic_nervous1.15989304
67MP0001216_abnormal_epidermal_layer1.14815218
68MP0002210_abnormal_sex_determination1.14632782
69MP0008932_abnormal_embryonic_tissue1.13170550
70MP0001502_abnormal_circadian_rhythm1.13059441
71MP0002166_altered_tumor_susceptibility1.12117211
72MP0002006_tumorigenesis1.12085657
73MP0003453_abnormal_keratinocyte_physiol1.11622894
74MP0003123_paternal_imprinting1.11562834
75MP0005646_abnormal_pituitary_gland1.11152402
76MP0005395_other_phenotype1.10466638
77MP0002734_abnormal_mechanical_nocicepti1.09914637
78MP0005253_abnormal_eye_physiology1.09397572
79MP0008961_abnormal_basal_metabolism1.07490319
80MP0005503_abnormal_tendon_morphology1.06757117
81MP0004808_abnormal_hematopoietic_stem1.05184692
82MP0002160_abnormal_reproductive_system1.04229424
83MP0008789_abnormal_olfactory_epithelium1.04033388
84MP0010094_abnormal_chromosome_stability1.03591129
85MP0002098_abnormal_vibrissa_morphology1.03033110
86MP0000537_abnormal_urethra_morphology1.02205290
87MP0005076_abnormal_cell_differentiation1.00209758
88MP0001299_abnormal_eye_distance/0.99968958
89MP0004272_abnormal_basement_membrane0.99679505
90MP0003656_abnormal_erythrocyte_physiolo0.98530566
91MP0005647_abnormal_sex_gland0.98081510
92MP0003045_fibrosis0.98063510
93MP0004043_abnormal_pH_regulation0.97764825
94MP0003890_abnormal_embryonic-extraembry0.97596794
95MP0006292_abnormal_olfactory_placode0.97521543
96MP0001545_abnormal_hematopoietic_system0.97442537
97MP0005397_hematopoietic_system_phenotyp0.97442537
98MP0010307_abnormal_tumor_latency0.95874445
99MP0008058_abnormal_DNA_repair0.95534953
100MP0002572_abnormal_emotion/affect_behav0.95002475
101MP0005171_absent_coat_pigmentation0.94556555
102MP0009745_abnormal_behavioral_response0.94362965
103MP0001835_abnormal_antigen_presentation0.93409461
104MP0003091_abnormal_cell_migration0.92779545
105MP0000653_abnormal_sex_gland0.90158151
106MP0004811_abnormal_neuron_physiology0.89895190
107MP0005408_hypopigmentation0.89832988
108MP0002075_abnormal_coat/hair_pigmentati0.88841105
109MP0004270_analgesia0.88727732
110MP0001968_abnormal_touch/_nociception0.88384420
111MP0001145_abnormal_male_reproductive0.87886480
112MP0009115_abnormal_fat_cell0.86183739
113MP0002067_abnormal_sensory_capabilities0.85586639
114MP0002092_abnormal_eye_morphology0.85566706
115MP0005174_abnormal_tail_pigmentation0.85361654
116MP0000955_abnormal_spinal_cord0.85222375
117MP0005075_abnormal_melanosome_morpholog0.85193212
118MP0002736_abnormal_nociception_after0.83773837
119MP0009840_abnormal_foam_cell0.83037610
120MP0003111_abnormal_nucleus_morphology0.82578245
121MP0002877_abnormal_melanocyte_morpholog0.82377144
122MP0005621_abnormal_cell_physiology0.82079065
123MP0002088_abnormal_embryonic_growth/wei0.81878205
124MP0002168_other_aberrant_phenotype0.81579530
125MP0002064_seizures0.81387447
126MP0001672_abnormal_embryogenesis/_devel0.81185973
127MP0005380_embryogenesis_phenotype0.81185973
128MP0001501_abnormal_sleep_pattern0.81093503
129MP0002086_abnormal_extraembryonic_tissu0.80960195
130MP0003172_abnormal_lysosome_physiology0.80809447
131MP0005310_abnormal_salivary_gland0.80715152
132MP0010352_gastrointestinal_tract_polyps0.80567733
133MP0003943_abnormal_hepatobiliary_system0.79372472
134MP0002161_abnormal_fertility/fecundity0.78982499
135MP0003879_abnormal_hair_cell0.78162013
136MP0003984_embryonic_growth_retardation0.77724709
137MP0001324_abnormal_eye_pigmentation0.77547522
138MP0003693_abnormal_embryo_hatching0.76848660
139MP0004957_abnormal_blastocyst_morpholog0.76845790
140MP0004197_abnormal_fetal_growth/weight/0.75881625
141MP0002876_abnormal_thyroid_physiology0.75460254
142MP0002396_abnormal_hematopoietic_system0.75006043
143MP0000428_abnormal_craniofacial_morphol0.74896190
144MP0001486_abnormal_startle_reflex0.74890025
145MP0005623_abnormal_meninges_morphology0.74534841
146MP0001186_pigmentation_phenotype0.73373036
147MP0003755_abnormal_palate_morphology0.73147895
148MP0002138_abnormal_hepatobiliary_system0.71812364
149MP0005391_vision/eye_phenotype0.71416136
150MP0002177_abnormal_outer_ear0.71238367
151MP0003385_abnormal_body_wall0.70996119
152MP0000432_abnormal_head_morphology0.70832712
153MP0001849_ear_inflammation0.69574998
154MP0002751_abnormal_autonomic_nervous0.69197114
155MP0003935_abnormal_craniofacial_develop0.68763762
156MP0002109_abnormal_limb_morphology0.67770316
157MP0002398_abnormal_bone_marrow0.67469676
158MP0002882_abnormal_neuron_morphology0.67467696
159MP0003861_abnormal_nervous_system0.66178203
160MP0002272_abnormal_nervous_system0.65793386
161MP0003315_abnormal_perineum_morphology0.65781884
162MP0001346_abnormal_lacrimal_gland0.65019967
163MP0002928_abnormal_bile_duct0.64957833
164MP0002277_abnormal_respiratory_mucosa0.64617202
165MP0002148_abnormal_hypersensitivity_rea0.63324311
166MP0002733_abnormal_thermal_nociception0.62490963
167MP0002557_abnormal_social/conspecific_i0.61307676
168MP0002116_abnormal_craniofacial_bone0.60709029

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)8.17323878
2Neonatal respiratory distress (HP:0002643)6.25430932
3Abnormality of the costochondral junction (HP:0000919)5.29543740
4Submucous cleft hard palate (HP:0000176)4.29884200
5Febrile seizures (HP:0002373)4.23499756
6Acute myeloid leukemia (HP:0004808)4.22199488
7Facial hemangioma (HP:0000329)3.79038151
8Exocrine pancreatic insufficiency (HP:0001738)3.43953569
9Cerebellar dysplasia (HP:0007033)3.24998734
10Type I diabetes mellitus (HP:0100651)3.23585783
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.91342022
12Aplasia cutis congenita (HP:0001057)2.90777797
13Focal motor seizures (HP:0011153)2.90174525
14Abnormality of the epiphysis of the femoral head (HP:0010574)2.88900656
15Abnormality of chromosome stability (HP:0003220)2.88056627
16Curly hair (HP:0002212)2.83576316
17Abnormality of the femoral head (HP:0003368)2.77470981
18Fair hair (HP:0002286)2.70870601
19Squamous cell carcinoma (HP:0002860)2.67867462
20Abnormality of femoral epiphyses (HP:0006499)2.66622014
21Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.66622014
22Capillary hemangiomas (HP:0005306)2.66118579
23Atonic seizures (HP:0010819)2.63056768
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.62050287
25Tubulointerstitial nephritis (HP:0001970)2.61438003
26Abnormality of the fingertips (HP:0001211)2.60939200
27Coxa vara (HP:0002812)2.58737278
28Tubular atrophy (HP:0000092)2.57882033
29Abnormality of the nasal septum (HP:0000419)2.57383264
30Prominent nose (HP:0000448)2.52606240
31Congenital stationary night blindness (HP:0007642)2.51975409
32Steatorrhea (HP:0002570)2.51605806
33Thoracolumbar scoliosis (HP:0002944)2.51233934
34Abnormal hair whorl (HP:0010721)2.49342291
35Abnormal sex determination (HP:0012244)2.46249072
36Sex reversal (HP:0012245)2.46249072
37Abnormal respiratory motile cilium physiology (HP:0012261)2.42507346
38Abnormal ciliary motility (HP:0012262)2.40691602
39Type II lissencephaly (HP:0007260)2.39403799
40Absent/shortened dynein arms (HP:0200106)2.38950724
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.38950724
42Ovoid vertebral bodies (HP:0003300)2.36834178
43Overlapping toe (HP:0001845)2.36377210
44Hypoplastic labia majora (HP:0000059)2.34443506
45Chin dimple (HP:0010751)2.33868749
46Focal seizures (HP:0007359)2.32724739
47Abnormality of the columella (HP:0009929)2.32150291
48Cutaneous finger syndactyly (HP:0010554)2.31371569
49Abnormality of the ileum (HP:0001549)2.31228014
50Lip pit (HP:0100267)2.30745063
51Widely spaced teeth (HP:0000687)2.26586553
52Clubbing of toes (HP:0100760)2.25222606
53Abnormality of the labia majora (HP:0012881)2.25212642
54Increased corneal curvature (HP:0100692)2.24135432
55Keratoconus (HP:0000563)2.24135432
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23710800
57Pancreatic fibrosis (HP:0100732)2.22789152
58Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.22746446
59High anterior hairline (HP:0009890)2.22615467
60Resting tremor (HP:0002322)2.20974993
61Meckel diverticulum (HP:0002245)2.20127787
62Neoplasm of the adrenal cortex (HP:0100641)2.19022505
63Myelodysplasia (HP:0002863)2.18272975
64Short thorax (HP:0010306)2.17246875
65Abnormality of the preputium (HP:0100587)2.16976242
66Deep palmar crease (HP:0006191)2.13038571
67Poikiloderma (HP:0001029)2.10811376
68Epileptic encephalopathy (HP:0200134)2.10189771
69Absent speech (HP:0001344)2.09095512
70Heterotopia (HP:0002282)2.06875203
71Papillary thyroid carcinoma (HP:0002895)2.06471209
72Specific learning disability (HP:0001328)2.05099715
73Hypothermia (HP:0002045)2.05093314
74Rhinitis (HP:0012384)2.04763741
75Milia (HP:0001056)2.03841837
76Acute lymphatic leukemia (HP:0006721)2.03303003
77Long eyelashes (HP:0000527)2.02456087
78Sloping forehead (HP:0000340)2.01815718
79Cystic liver disease (HP:0006706)2.01315173
80Sensory axonal neuropathy (HP:0003390)2.00781169
81Metaphyseal dysplasia (HP:0100255)10.4391038
82Truncal obesity (HP:0001956)1.99028989
83Generalized hypopigmentation of hair (HP:0011358)1.98673153
84Mask-like facies (HP:0000298)1.95486411
85Cutaneous syndactyly (HP:0012725)1.94609582
86Aplasia/hypoplasia of the uterus (HP:0008684)1.93515995
87Abnormality of the renal medulla (HP:0100957)1.92684389
88Protruding tongue (HP:0010808)1.91229988
89Absent frontal sinuses (HP:0002688)1.90738980
90Median cleft lip (HP:0000161)1.88902416
91Deep philtrum (HP:0002002)1.87201812
92Exotropia (HP:0000577)1.86586675
93Volvulus (HP:0002580)1.81599304
94Bradycardia (HP:0001662)1.81572650
95Broad palm (HP:0001169)1.81326800
96Abnormal respiratory motile cilium morphology (HP:0005938)1.80805960
97Abnormal respiratory epithelium morphology (HP:0012253)1.80805960
98Skull defect (HP:0001362)1.80800606
99Abnormal pancreas size (HP:0012094)1.80400545
100Carpal bone hypoplasia (HP:0001498)1.79778414
101Distal arthrogryposis (HP:0005684)1.78515835
102Pancreatic cysts (HP:0001737)1.75387856
103Abnormality of DNA repair (HP:0003254)1.75321733
104Genetic anticipation (HP:0003743)1.75121073
105Cystic hygroma (HP:0000476)1.75113235
106Hypoplastic iliac wings (HP:0002866)1.73720326
107Pectus carinatum (HP:0000768)1.73462898
108Hypoplasia of the uterus (HP:0000013)1.72527992
109Hip dysplasia (HP:0001385)1.72240379
110Abnormality of the carotid arteries (HP:0005344)1.72086137
111Infertility (HP:0000789)1.71628095
112Progressive cerebellar ataxia (HP:0002073)1.70418441
113Bone marrow hypocellularity (HP:0005528)1.69314122
114Renal hypoplasia (HP:0000089)1.69285515
115Small hand (HP:0200055)1.69215989
116Male pseudohermaphroditism (HP:0000037)1.68443414
117Intellectual disability, mild (HP:0001256)1.67009151
118B lymphocytopenia (HP:0010976)1.66871114
119Chromsome breakage (HP:0040012)1.66364240
120Tubulointerstitial abnormality (HP:0001969)1.65901059
121Impaired smooth pursuit (HP:0007772)1.65384629
122Bronchiectasis (HP:0002110)1.65098036
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64001024
124Abnormality of the intrinsic pathway (HP:0010989)1.63769930
125Basal cell carcinoma (HP:0002671)1.63408966
126Oligodactyly (hands) (HP:0001180)1.62655193
127Cubitus valgus (HP:0002967)1.62589078
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62263201
129Absence seizures (HP:0002121)1.61905523
130Fibular hypoplasia (HP:0003038)1.61758677
131Abnormality of incisor morphology (HP:0011063)1.60986676
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.60939902
133Eosinophilia (HP:0001880)1.58579100
134Lissencephaly (HP:0001339)1.57942105
135Down-sloping shoulders (HP:0200021)1.57572566
136Abnormality of lateral ventricle (HP:0030047)1.57568116
137Abnormality of the incisor (HP:0000676)1.57055425
138Poor head control (HP:0002421)1.57030884
139Bulbous nose (HP:0000414)1.56887692
140Vertebral arch anomaly (HP:0008438)1.56778851
141Thick nail (HP:0001805)1.56662585
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.56387624
143Small intestinal stenosis (HP:0012848)1.56161543
144Spinal cord lesions (HP:0100561)1.55986862
145Syringomyelia (HP:0003396)1.55986862
146Nephrocalcinosis (HP:0000121)1.54890738
147Limited hip movement (HP:0008800)1.53760104
148Lower limb amyotrophy (HP:0007210)1.53045291
149Narrow palate (HP:0000189)1.52891205
150True hermaphroditism (HP:0010459)1.51357932
151Increased number of teeth (HP:0011069)1.49850295
152Aqueductal stenosis (HP:0002410)1.47994911
153Distal lower limb amyotrophy (HP:0008944)1.47127367
154Postaxial foot polydactyly (HP:0001830)1.46883061
155Ectopic kidney (HP:0000086)1.46579336
156Narrow chest (HP:0000774)1.45226149
157Trigonocephaly (HP:0000243)1.43559492
158Mesomelia (HP:0003027)1.43365678
159Chronic hepatic failure (HP:0100626)1.43126434
160Progressive sensorineural hearing impairment (HP:0000408)1.41319198
161Abnormality of midbrain morphology (HP:0002418)1.39602356
162Molar tooth sign on MRI (HP:0002419)1.39602356
163Areflexia of lower limbs (HP:0002522)1.38492230
164Absent phalangeal crease (HP:0006109)1.37620637
165Midline defect of the nose (HP:0004122)1.36364672
166Dyschromatopsia (HP:0007641)1.36298420
167Open mouth (HP:0000194)1.36212587
168Nephronophthisis (HP:0000090)1.35604181
169Scanning speech (HP:0002168)1.35235521
170Central scotoma (HP:0000603)1.34994000
171Prostate neoplasm (HP:0100787)1.34744189
172Gaze-evoked nystagmus (HP:0000640)1.34489614
173Thyroid carcinoma (HP:0002890)1.33866396
174Progressive hearing impairment (HP:0001730)1.33111905
175Abnormality of the frontal sinuses (HP:0002687)1.32433368
176Absent eyebrow (HP:0002223)1.32204899
177Truncal ataxia (HP:0002078)1.31959394
178Dislocated radial head (HP:0003083)1.31155131
179Gait imbalance (HP:0002141)1.30827290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.93875447
2PINK14.91225703
3SIK33.12060072
4NEK23.02566987
5ZAK2.75788456
6MAP3K92.67030347
7CASK2.62728132
8EIF2AK32.62438747
9SGK22.43408252
10PNCK2.26380482
11BRD42.23065560
12MAP3K142.22480139
13CDK122.07628788
14BRSK22.03862432
15NTRK32.00214896
16PLK21.97830302
17MELK1.97824874
18ERBB31.87759101
19MAP2K71.86322165
20PRPF4B1.84018698
21SGK31.71802256
22FGFR31.71226226
23NUAK11.66605752
24TGFBR11.57893586
25MAP3K41.57602165
26TNIK1.55782786
27TXK1.54925418
28FRK1.52952011
29EIF2AK21.50696993
30MAP3K21.49426149
31TAOK11.48599915
32YES11.41766632
33DYRK31.36379708
34JAK31.35387064
35TAOK21.34665895
36CSNK1A1L1.32594007
37BMPR21.32167693
38WEE11.27613889
39LATS21.26769939
40TRIM281.24221365
41BMPR1B1.23296534
42MAPK131.21764185
43PLK31.21351931
44STK241.20806181
45EPHA31.20053471
46STK38L1.17283270
47SGK4941.16887493
48SGK2231.16887493
49BCR1.08413980
50IRAK11.03920045
51CAMKK20.99587069
52MAPK150.96096115
53MINK10.95866251
54CDC42BPA0.95559033
55PDGFRB0.95429587
56TRPM70.95349221
57NTRK20.93617010
58CHUK0.91799562
59SIK20.91247282
60SRPK10.90030127
61RPS6KB10.88692719
62STK380.88610472
63MET0.88582694
64CDK30.80918386
65INSRR0.79927286
66MARK10.78776408
67SGK10.78262422
68PKN20.77918062
69MARK30.76660323
70CAMK1G0.76154782
71TLK10.75884422
72JAK10.75617143
73WNK40.75411441
74CSNK1G10.75064510
75CLK10.74755365
76MTOR0.74467346
77LATS10.72982690
78STK30.72546807
79CDK90.72119345
80CSNK1G30.71753441
81PLK40.71347425
82RPS6KA50.70459170
83MST40.69429867
84LMTK20.68337099
85CHEK20.67748178
86MKNK20.66747050
87TSSK60.63853377
88MAPK100.63064409
89FER0.63003530
90BRAF0.60502564
91CAMK1D0.59830785
92EIF2AK10.59817670
93CDC70.59805125
94WNK10.59690612
95KSR10.58883755
96RPS6KA20.58309038
97ADRBK20.56889326
98PRKCE0.56888748
99MST1R0.56860314
100NEK60.56484753
101CSNK1G20.55127184
102MAPK80.55117756
103ATM0.54830395
104ATR0.54115289
105MAP3K130.51673897
106TNK20.50058589
107PTK2B0.49909358
108STK390.47924986
109PLK10.46235692
110CHEK10.45513397
111PRKCQ0.45273820
112GSK3B0.45260100
113MAP3K50.44411102
114PIM20.44408540
115DYRK1A0.44145483
116ACVR1B0.43834472
117MAP3K120.43428411
118TEC0.43344243
119PRKAA10.41329241
120MAPK140.41296762
121MYLK0.40989784
122EGFR0.40988041
123PIK3CA0.39870975
124CCNB10.39453244
125PRKCG0.38706147
126IRAK40.38318550
127FGR0.38160236
128CDK80.37654872
129CDK10.37160177
130MKNK10.36980440
131TAF10.36594658
132PRKCB0.35617301
133NLK0.35195105
134TTK0.35049424
135PAK20.34830874
136MAPK10.33766841
137CAMKK10.33245874
138AKT10.33193731
139PRKCH0.32940656
140MAP2K40.32399902
141STK100.32223619
142ADRBK10.31766596
143CDK70.31510111
144RET0.31316378
145CDK20.31202285
146PBK0.30944873
147MOS0.30814908
148EPHB20.29509582
149WNK30.29022074
150STK40.27810549
151IKBKB0.27090681

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.90038036
2Basal transcription factors_Homo sapiens_hsa030222.60798043
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02609336
4Phototransduction_Homo sapiens_hsa047441.75260547
5Synaptic vesicle cycle_Homo sapiens_hsa047211.72715286
6Nicotine addiction_Homo sapiens_hsa050331.69119245
7Homologous recombination_Homo sapiens_hsa034401.64991675
8Olfactory transduction_Homo sapiens_hsa047401.61293389
9Apoptosis_Homo sapiens_hsa042101.59925963
10Gap junction_Homo sapiens_hsa045401.57713300
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52795500
12Taste transduction_Homo sapiens_hsa047421.46554898
13Thyroid cancer_Homo sapiens_hsa052161.43563208
14Lysine degradation_Homo sapiens_hsa003101.36795075
15Nucleotide excision repair_Homo sapiens_hsa034201.32073909
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30139703
17Allograft rejection_Homo sapiens_hsa053301.29581866
18TGF-beta signaling pathway_Homo sapiens_hsa043501.28707925
19Circadian entrainment_Homo sapiens_hsa047131.26659509
20Dorso-ventral axis formation_Homo sapiens_hsa043201.26122430
21Morphine addiction_Homo sapiens_hsa050321.21572337
22Type I diabetes mellitus_Homo sapiens_hsa049401.18984589
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17843211
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08623238
25ErbB signaling pathway_Homo sapiens_hsa040121.07820193
26Type II diabetes mellitus_Homo sapiens_hsa049301.07504987
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.06868785
28Sphingolipid metabolism_Homo sapiens_hsa006001.06660950
29Long-term potentiation_Homo sapiens_hsa047201.05093495
30* Hedgehog signaling pathway_Homo sapiens_hsa043401.04845656
31Endometrial cancer_Homo sapiens_hsa052131.04250340
32Autoimmune thyroid disease_Homo sapiens_hsa053201.04047533
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03531822
34Small cell lung cancer_Homo sapiens_hsa052221.02673974
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02229423
36Alcoholism_Homo sapiens_hsa050341.01378181
37Measles_Homo sapiens_hsa051621.00728390
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99973494
39Colorectal cancer_Homo sapiens_hsa052100.99513787
40Glioma_Homo sapiens_hsa052140.99096763
41Cholinergic synapse_Homo sapiens_hsa047250.99027246
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98409331
43Insulin secretion_Homo sapiens_hsa049110.98022791
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97336877
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96849129
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96419976
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95093736
48Viral carcinogenesis_Homo sapiens_hsa052030.94669598
49Dopaminergic synapse_Homo sapiens_hsa047280.93820392
50Serotonergic synapse_Homo sapiens_hsa047260.93683631
51MAPK signaling pathway_Homo sapiens_hsa040100.93365548
52Glutamatergic synapse_Homo sapiens_hsa047240.93229075
53Nitrogen metabolism_Homo sapiens_hsa009100.92055930
54Graft-versus-host disease_Homo sapiens_hsa053320.91974085
55Phagosome_Homo sapiens_hsa041450.91950653
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.91917841
57Systemic lupus erythematosus_Homo sapiens_hsa053220.91728832
58Non-homologous end-joining_Homo sapiens_hsa034500.91233766
59Axon guidance_Homo sapiens_hsa043600.90108005
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89807544
61Regulation of autophagy_Homo sapiens_hsa041400.89733280
62Prolactin signaling pathway_Homo sapiens_hsa049170.89136491
63Adherens junction_Homo sapiens_hsa045200.87976252
64Melanoma_Homo sapiens_hsa052180.87954682
65RNA transport_Homo sapiens_hsa030130.87042792
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.86808909
67Fanconi anemia pathway_Homo sapiens_hsa034600.86504614
68Hippo signaling pathway_Homo sapiens_hsa043900.84794044
69Renal cell carcinoma_Homo sapiens_hsa052110.84305643
70B cell receptor signaling pathway_Homo sapiens_hsa046620.84123480
71Chronic myeloid leukemia_Homo sapiens_hsa052200.83397971
72Influenza A_Homo sapiens_hsa051640.83344985
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83220147
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83063730
75Selenocompound metabolism_Homo sapiens_hsa004500.82417345
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81967564
77Pancreatic cancer_Homo sapiens_hsa052120.81600384
78T cell receptor signaling pathway_Homo sapiens_hsa046600.81098710
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.80987542
80Legionellosis_Homo sapiens_hsa051340.80895638
81Primary immunodeficiency_Homo sapiens_hsa053400.80737850
82MicroRNAs in cancer_Homo sapiens_hsa052060.80680036
83Acute myeloid leukemia_Homo sapiens_hsa052210.80301779
84Mismatch repair_Homo sapiens_hsa034300.79672588
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79300216
86Oxytocin signaling pathway_Homo sapiens_hsa049210.79158062
87Rheumatoid arthritis_Homo sapiens_hsa053230.78890264
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78425919
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78408342
90TNF signaling pathway_Homo sapiens_hsa046680.78383530
91Hepatitis C_Homo sapiens_hsa051600.77707598
92Chemokine signaling pathway_Homo sapiens_hsa040620.77600686
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77011273
94Cell cycle_Homo sapiens_hsa041100.76549195
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76530550
96Collecting duct acid secretion_Homo sapiens_hsa049660.76400013
97Oocyte meiosis_Homo sapiens_hsa041140.76292213
98FoxO signaling pathway_Homo sapiens_hsa040680.75496411
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75493056
100Salivary secretion_Homo sapiens_hsa049700.75327801
101Long-term depression_Homo sapiens_hsa047300.75100944
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74375107
103Amphetamine addiction_Homo sapiens_hsa050310.74366167
104Renin secretion_Homo sapiens_hsa049240.73862507
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.72838808
106Hepatitis B_Homo sapiens_hsa051610.72673815
107Prostate cancer_Homo sapiens_hsa052150.72354517
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72277300
109p53 signaling pathway_Homo sapiens_hsa041150.71402315
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71350573
111Viral myocarditis_Homo sapiens_hsa054160.71020228
112Proteoglycans in cancer_Homo sapiens_hsa052050.70907747
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70520121
114GABAergic synapse_Homo sapiens_hsa047270.70446512
115Leishmaniasis_Homo sapiens_hsa051400.70409318
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70121960
117mRNA surveillance pathway_Homo sapiens_hsa030150.69633535
118Circadian rhythm_Homo sapiens_hsa047100.69587494
119Bladder cancer_Homo sapiens_hsa052190.69489330
120Basal cell carcinoma_Homo sapiens_hsa052170.69211810
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68881771
122Dilated cardiomyopathy_Homo sapiens_hsa054140.68701481
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68216297
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67110526
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67039463
126Toxoplasmosis_Homo sapiens_hsa051450.66788885
127Salmonella infection_Homo sapiens_hsa051320.66369834
128mTOR signaling pathway_Homo sapiens_hsa041500.66010582
129Herpes simplex infection_Homo sapiens_hsa051680.65745996
130cAMP signaling pathway_Homo sapiens_hsa040240.65220966
131Choline metabolism in cancer_Homo sapiens_hsa052310.64604640
132Calcium signaling pathway_Homo sapiens_hsa040200.64600237
133Ras signaling pathway_Homo sapiens_hsa040140.64152453
134Inositol phosphate metabolism_Homo sapiens_hsa005620.64134013
135Estrogen signaling pathway_Homo sapiens_hsa049150.64077667
136Pathways in cancer_Homo sapiens_hsa052000.63691159
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63576042
138Non-small cell lung cancer_Homo sapiens_hsa052230.63333087
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63253578
140Osteoclast differentiation_Homo sapiens_hsa043800.62941657
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62103322
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61015705
143GnRH signaling pathway_Homo sapiens_hsa049120.60834647
144RNA degradation_Homo sapiens_hsa030180.60611896
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59644886
146Wnt signaling pathway_Homo sapiens_hsa043100.59365426
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59364410
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58468517
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56947738
150Focal adhesion_Homo sapiens_hsa045100.52985666
151Protein export_Homo sapiens_hsa030600.48294784
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41940411

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