CSNK1G2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.27711863
2cell wall macromolecule catabolic process (GO:0016998)5.11001621
3cell wall macromolecule metabolic process (GO:0044036)5.11001621
4fusion of sperm to egg plasma membrane (GO:0007342)4.65517105
5negative regulation of cell killing (GO:0031342)4.60661025
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60661025
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49997344
8sperm-egg recognition (GO:0035036)4.37585764
9negative regulation of cell size (GO:0045792)4.31501417
10positive regulation of gamma-delta T cell activation (GO:0046645)4.30031877
11positive regulation of histone deacetylation (GO:0031065)4.25099429
12positive regulation by symbiont of host defense response (GO:0052509)4.21798704
13modulation by symbiont of host defense response (GO:0052031)4.21798704
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21798704
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21798704
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.21798704
17modulation by symbiont of host immune response (GO:0052553)4.21798704
18acrosome reaction (GO:0007340)4.20725046
19acrosome assembly (GO:0001675)4.19810068
20heterochromatin organization (GO:0070828)4.17047864
21binding of sperm to zona pellucida (GO:0007339)4.16465040
22sexual reproduction (GO:0019953)4.16214743
23cell-cell recognition (GO:0009988)4.09162795
24antigen processing and presentation of endogenous antigen (GO:0019883)4.07761940
25peptidyl-lysine dimethylation (GO:0018027)3.98556604
26chromosome condensation (GO:0030261)3.90755001
27response to muramyl dipeptide (GO:0032495)3.64900450
28spermatid development (GO:0007286)3.64250696
29plasma membrane fusion (GO:0045026)3.63073983
30thymic T cell selection (GO:0045061)3.61826724
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.57496329
32maternal placenta development (GO:0001893)3.56929156
33synaptonemal complex assembly (GO:0007130)3.55045850
34mannose metabolic process (GO:0006013)3.48721041
35response to peptidoglycan (GO:0032494)3.45598221
36regulation of translational fidelity (GO:0006450)3.44202092
37leukocyte aggregation (GO:0070486)3.44150680
38regulation of gamma-delta T cell activation (GO:0046643)3.39912319
39regulation of hippo signaling (GO:0035330)3.39475350
40detection of other organism (GO:0098543)3.38087709
41detection of bacterium (GO:0016045)3.35733808
42DNA packaging (GO:0006323)3.34466973
43regulation of fatty acid beta-oxidation (GO:0031998)3.31746330
44macrophage activation involved in immune response (GO:0002281)3.29890137
45chromatin silencing (GO:0006342)3.28587852
46synaptonemal complex organization (GO:0070193)3.27365859
47negative regulation of inclusion body assembly (GO:0090084)3.21125687
48adherens junction assembly (GO:0034333)3.20213687
493-UTR-mediated mRNA stabilization (GO:0070935)3.18403821
50morphogenesis of an endothelium (GO:0003159)3.16379100
51endothelial tube morphogenesis (GO:0061154)3.16379100
52T cell selection (GO:0045058)3.15215990
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.14999868
54response to laminar fluid shear stress (GO:0034616)3.14801865
55negative thymic T cell selection (GO:0045060)3.09775310
56reproduction (GO:0000003)3.09707083
57protein-DNA complex disassembly (GO:0032986)3.07789537
58nucleosome disassembly (GO:0006337)3.07789537
594-hydroxyproline metabolic process (GO:0019471)3.07765953
60pre-miRNA processing (GO:0031054)3.07320033
61positive regulation of Cdc42 GTPase activity (GO:0043089)3.07119245
62NIK/NF-kappaB signaling (GO:0038061)3.06288345
63positive regulation of protein deacetylation (GO:0090312)3.04852786
64protein localization to endosome (GO:0036010)3.04280075
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04174476
66focal adhesion assembly (GO:0048041)3.03784725
67cell-substrate adherens junction assembly (GO:0007045)3.03784725
68regulation of translational termination (GO:0006449)3.03740387
69plasma membrane repair (GO:0001778)3.02564654
70intracellular estrogen receptor signaling pathway (GO:0030520)3.02297567
71positive T cell selection (GO:0043368)3.00196827
72organic cation transport (GO:0015695)2.98936263
73regulation of T-helper 2 cell differentiation (GO:0045628)2.98927666
74NLS-bearing protein import into nucleus (GO:0006607)2.96620511
75regulation of B cell receptor signaling pathway (GO:0050855)2.96173042
76modulation by virus of host process (GO:0019054)2.95318919
77RNA stabilization (GO:0043489)2.94320715
78mRNA stabilization (GO:0048255)2.94320715
79tolerance induction (GO:0002507)2.93489171
80chaperone-mediated protein complex assembly (GO:0051131)2.91291429
81neutrophil activation involved in immune response (GO:0002283)2.90767979
82modulation by symbiont of host cellular process (GO:0044068)2.90018684
83negative T cell selection (GO:0043383)2.89934571
84regulation of leukocyte degranulation (GO:0043300)2.88873920
85motile cilium assembly (GO:0044458)2.88462894
86cell-substrate junction assembly (GO:0007044)2.88378122
87histone H3-K36 demethylation (GO:0070544)2.87043754
88cellular hyperosmotic response (GO:0071474)2.86633305
89germinal center formation (GO:0002467)2.85180348
90regulation of cholesterol homeostasis (GO:2000188)2.84442411
91B cell receptor signaling pathway (GO:0050853)2.83634896
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80080491
93multicellular organism reproduction (GO:0032504)2.79276323
94regulation of interferon-beta biosynthetic process (GO:0045357)2.77685994
95negative regulation of gene expression, epigenetic (GO:0045814)2.77421689
96regulation of histone H3-K27 methylation (GO:0061085)2.77360788
97detection of external biotic stimulus (GO:0098581)2.76715188
98cellular extravasation (GO:0045123)2.76102095
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75433008
100regulation of inclusion body assembly (GO:0090083)2.75021169
101establishment of apical/basal cell polarity (GO:0035089)2.74157218
102negative regulation of fatty acid transport (GO:2000192)2.74109557
103peptidyl-proline hydroxylation (GO:0019511)2.74056776
104regulation of defense response to virus by virus (GO:0050690)2.73940266
105stress fiber assembly (GO:0043149)2.73543760
106negative regulation of interleukin-12 production (GO:0032695)2.73401547
107protein hydroxylation (GO:0018126)2.73036557
108negative regulation of toll-like receptor signaling pathway (GO:0034122)2.72691343
109negative regulation of phagocytosis (GO:0050765)2.71666032
110apoptotic process involved in morphogenesis (GO:0060561)2.70196243
111gene silencing (GO:0016458)2.69241383
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67451069
113regulation of mast cell degranulation (GO:0043304)2.66025341
114glycolytic process (GO:0006096)2.65635775
115negative regulation of leukocyte mediated immunity (GO:0002704)2.65239200
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.65077018
117amino-acid betaine transport (GO:0015838)2.64743964
118carnitine transport (GO:0015879)2.64743964
119spermatogenesis (GO:0007283)2.64383220
120male gamete generation (GO:0048232)2.62926427
121response to host (GO:0075136)2.62328489
122response to host defenses (GO:0052200)2.62328489
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62328489
124negative regulation of cardiac muscle tissue growth (GO:0055022)2.60566678
125negative regulation of heart growth (GO:0061117)2.60566678
126positive regulation of nuclease activity (GO:0032075)2.60272316
127regulation of NFAT protein import into nucleus (GO:0051532)2.60142897
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59465544
129response to host immune response (GO:0052572)2.59465544
130regulation of ARF protein signal transduction (GO:0032012)2.58766526
131signal complex assembly (GO:0007172)2.57565502
132response to interleukin-15 (GO:0070672)2.56891843
133carnitine transmembrane transport (GO:1902603)2.56671757
134negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56655748
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56469910
136negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.54551911
137regulation of chromatin binding (GO:0035561)2.52950532
138mitotic G1 DNA damage checkpoint (GO:0031571)2.52923100
139chromatin assembly (GO:0031497)2.52786412
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52076272
141regulation of ARF GTPase activity (GO:0032312)2.51080118
142respiratory burst (GO:0045730)2.50957168
143activation of JUN kinase activity (GO:0007257)2.50360685
144detection of biotic stimulus (GO:0009595)2.49379608
145cellular response to virus (GO:0098586)2.49072762
146positive thymic T cell selection (GO:0045059)2.48824205
147embryonic process involved in female pregnancy (GO:0060136)2.47669809
148histone H4 deacetylation (GO:0070933)2.47615656
149regulation of early endosome to late endosome transport (GO:2000641)2.47531271
150negative regulation of myotube differentiation (GO:0010832)2.47000460
151negative regulation of granulocyte differentiation (GO:0030853)2.45842911
152negative regulation of erythrocyte differentiation (GO:0045647)2.45735717
153natural killer cell differentiation (GO:0001779)2.45214349
154seminiferous tubule development (GO:0072520)2.43892114
155type I interferon signaling pathway (GO:0060337)2.43536280
156cellular response to type I interferon (GO:0071357)2.43536280
157response to type I interferon (GO:0034340)2.43247483
158regulation of tight junction assembly (GO:2000810)2.42294442
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40815078
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40815078
161antigen processing and presentation via MHC class Ib (GO:0002475)2.40785068
162regulation of extracellular matrix disassembly (GO:0010715)2.40684458
163trophectodermal cell differentiation (GO:0001829)2.40498410
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40466002
165detection of molecule of bacterial origin (GO:0032490)2.40407154
166regulation of necroptotic process (GO:0060544)2.40374389
167negative regulation of potassium ion transmembrane transport (GO:1901380)2.39257865
168positive regulation of fatty acid beta-oxidation (GO:0032000)2.38368269
169epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37994837
170negative regulation of nucleotide catabolic process (GO:0030812)2.37603276
171positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37154156
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37109745
173regulation of fatty acid oxidation (GO:0046320)2.36248409
174immunoglobulin mediated immune response (GO:0016064)2.36098030
175gamete generation (GO:0007276)2.35116311
176cellular response to epidermal growth factor stimulus (GO:0071364)2.33604497
177regulation of gamma-delta T cell differentiation (GO:0045586)2.32765210
178regulation of nuclease activity (GO:0032069)2.32022016
179blood vessel endothelial cell migration (GO:0043534)2.31480228
180planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31443020
181insulin-like growth factor receptor signaling pathway (GO:0048009)2.30787301
182epithelial cell-cell adhesion (GO:0090136)2.30191969
183protein localization to chromosome, centromeric region (GO:0071459)2.29715940
184glucocorticoid receptor signaling pathway (GO:0042921)2.29110355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.21124196
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.04034860
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85104782
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70734782
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68785115
6* TCF7_22412390_ChIP-Seq_EML_Mouse2.57484492
7* KDM2B_26808549_Chip-Seq_DND41_Human2.50586998
8ZNF263_19887448_ChIP-Seq_K562_Human2.49213138
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.45559092
10* LXR_22292898_ChIP-Seq_THP-1_Human2.39433597
11VDR_21846776_ChIP-Seq_THP-1_Human2.32818082
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28568328
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23766022
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23278670
15* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12828001
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12104525
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05756778
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.98957532
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86981509
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84018287
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83467888
22RACK7_27058665_Chip-Seq_MCF-7_Human1.78386976
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76506541
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71898405
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71632455
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68481717
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.64305184
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62874470
29* UTX_26944678_Chip-Seq_JUKART_Human1.62086293
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.60408177
31* MAF_26560356_Chip-Seq_TH1_Human1.59447703
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.59354022
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.58229302
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57714755
35* P68_20966046_ChIP-Seq_HELA_Human1.57024866
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56839653
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.54073912
38KDM2B_26808549_Chip-Seq_K562_Human1.53019338
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52794402
40ATF3_27146783_Chip-Seq_COLON_Human1.52540085
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51355716
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50110010
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49635977
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49186388
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47968546
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44529149
47BCOR_27268052_Chip-Seq_Bcells_Human1.44433835
48CREB1_26743006_Chip-Seq_LNCaP_Human1.40885656
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.39730178
50SPI1_23127762_ChIP-Seq_K562_Human1.39434438
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38054841
52* NCOR1_26117541_ChIP-Seq_K562_Human1.36649717
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.34946285
54TP53_22127205_ChIP-Seq_IMR90_Human1.34678504
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34444709
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33542882
57SMC4_20622854_ChIP-Seq_HELA_Human1.33455146
58BCL6_27268052_Chip-Seq_Bcells_Human1.33161944
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32246011
60SCL_19346495_ChIP-Seq_HPC-7_Human1.31891239
61CLOCK_20551151_ChIP-Seq_293T_Human1.31647639
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31361075
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.30842042
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29577109
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29430187
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28581295
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28104827
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.28046867
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.28046867
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27009427
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26952968
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25531623
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25244616
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.25046692
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24464173
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23875299
77MAF_26560356_Chip-Seq_TH2_Human1.22802848
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22616410
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.21316504
80* MYB_26560356_Chip-Seq_TH1_Human1.21107627
81PHF8_20622854_ChIP-Seq_HELA_Human1.20553102
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20490802
83* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20114550
84LXR_22158963_ChIP-Seq_LIVER_Mouse1.19757599
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19226212
86* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19156389
87SPI1_23547873_ChIP-Seq_NB4_Human1.19084426
88VDR_24763502_ChIP-Seq_THP-1_Human1.18514454
89TP63_22573176_ChIP-Seq_HFKS_Human1.18054996
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17610476
91* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16237378
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16157856
93* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15354648
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14767699
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14506596
96* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14347766
97* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14277784
98* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14140207
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13626703
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11539467
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11480404
102E2F7_22180533_ChIP-Seq_HELA_Human1.11298174
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11250221
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10793567
105CTCF_21964334_Chip-Seq_Bcells_Human1.10732924
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10704143
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09555881
108RUNX_20019798_ChIP-Seq_JUKART_Human1.09513364
109MYB_26560356_Chip-Seq_TH2_Human1.08590954
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08558276
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08324836
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.07948524
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07437372
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07194751
115* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06316758
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06064564
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04835590
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03557344
119CTCF_27219007_Chip-Seq_Bcells_Human1.02214580
120* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02087456
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01588592
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.00685442
123SPI1_20517297_ChIP-Seq_HL60_Human1.00172807
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00141513
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99791847
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98829370
127E2F1_20622854_ChIP-Seq_HELA_Human0.97867602
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96995700
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96986478
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.96426191
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96410432
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96018493
133* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95808212
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94474549
135* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92538705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.04697945
2MP0003705_abnormal_hypodermis_morpholog4.84995586
3MP0003436_decreased_susceptibility_to3.64328410
4MP0005451_abnormal_body_composition2.77712764
5MP0010352_gastrointestinal_tract_polyps2.61792821
6MP0003763_abnormal_thymus_physiology2.53104186
7MP0008260_abnormal_autophagy2.49797318
8MP0003300_gastrointestinal_ulcer2.34437574
9MP0005076_abnormal_cell_differentiation2.28604761
10MP0003172_abnormal_lysosome_physiology2.24347034
11MP0009278_abnormal_bone_marrow2.17005933
12MP0001835_abnormal_antigen_presentation2.16844335
13MP0010234_abnormal_vibrissa_follicle2.16104913
14MP0005623_abnormal_meninges_morphology2.12895474
15MP0002419_abnormal_innate_immunity2.06590546
16MP0004233_abnormal_muscle_weight2.04675309
17MP0003724_increased_susceptibility_to2.04431546
18MP0003566_abnormal_cell_adhesion2.00579239
19MP0005025_abnormal_response_to1.98698719
20MP0005058_abnormal_lysosome_morphology1.97556832
21MP0008961_abnormal_basal_metabolism1.97071817
22MP0001849_ear_inflammation1.95832901
23MP0001800_abnormal_humoral_immune1.92334287
24MP0005000_abnormal_immune_tolerance1.91504497
25MP0008438_abnormal_cutaneous_collagen1.91001852
26MP0009333_abnormal_splenocyte_physiolog1.89069002
27MP0002420_abnormal_adaptive_immunity1.79789590
28MP0005387_immune_system_phenotype1.79004883
29MP0001790_abnormal_immune_system1.79004883
30MP0001819_abnormal_immune_cell1.78622519
31MP0005670_abnormal_white_adipose1.78007060
32MP0002723_abnormal_immune_serum1.73996737
33MP0002398_abnormal_bone_marrow1.69549025
34MP0002452_abnormal_antigen_presenting1.68318422
35MP0000703_abnormal_thymus_morphology1.66225938
36MP0004185_abnormal_adipocyte_glucose1.65697786
37MP0000858_altered_metastatic_potential1.65440813
38MP0000733_abnormal_muscle_development1.65394112
39MP0000678_abnormal_parathyroid_gland1.63975451
40MP0001533_abnormal_skeleton_physiology1.62283943
41MP0000751_myopathy1.56746858
42MP0005666_abnormal_adipose_tissue1.56349530
43MP0004381_abnormal_hair_follicle1.55208519
44MP0003698_abnormal_male_reproductive1.54537692
45MP0005464_abnormal_platelet_physiology1.53254211
46MP0003303_peritoneal_inflammation1.52596425
47MP0005671_abnormal_response_to1.52058415
48MP0004087_abnormal_muscle_fiber1.49233717
49MP0000716_abnormal_immune_system1.49062598
50MP0001929_abnormal_gametogenesis1.48974357
51MP0002405_respiratory_system_inflammati1.48468215
52MP0003283_abnormal_digestive_organ1.43949913
53MP0003453_abnormal_keratinocyte_physiol1.41178355
54MP0000537_abnormal_urethra_morphology1.40892068
55MP0004130_abnormal_muscle_cell1.40143142
56MP0010155_abnormal_intestine_physiology1.39763565
57MP0001730_embryonic_growth_arrest1.39507608
58MP0002722_abnormal_immune_system1.38928717
59MP0010630_abnormal_cardiac_muscle1.38559604
60MP0003279_aneurysm1.38149537
61MP0005375_adipose_tissue_phenotype1.37781728
62MP0001873_stomach_inflammation1.36477138
63MP0005275_abnormal_skin_tensile1.34663624
64MP0002269_muscular_atrophy1.33982657
65MP0002132_abnormal_respiratory_system1.33831512
66MP0004084_abnormal_cardiac_muscle1.33755626
67MP0005023_abnormal_wound_healing1.33700077
68MP0002998_abnormal_bone_remodeling1.33390898
69MP0003828_pulmonary_edema1.32987615
70MP0003115_abnormal_respiratory_system1.32502645
71MP0009053_abnormal_anal_canal1.31595561
72MP0002429_abnormal_blood_cell1.29858104
73MP0002234_abnormal_pharynx_morphology1.28981834
74MP0002877_abnormal_melanocyte_morpholog1.28055874
75MP0009785_altered_susceptibility_to1.27514120
76MP0009840_abnormal_foam_cell1.26872064
77MP0004197_abnormal_fetal_growth/weight/1.26307853
78MP0010307_abnormal_tumor_latency1.25885390
79MP0005409_darkened_coat_color1.22483340
80MP0004808_abnormal_hematopoietic_stem1.20239547
81MP0001851_eye_inflammation1.18259120
82MP0002653_abnormal_ependyma_morphology1.18038087
83MP0000689_abnormal_spleen_morphology1.17064222
84MP0006082_CNS_inflammation1.16250506
85MP0005360_urolithiasis1.16167184
86MP0000003_abnormal_adipose_tissue1.14532363
87MP0000490_abnormal_crypts_of1.13765844
88MP0003866_abnormal_defecation1.13559321
89MP0002249_abnormal_larynx_morphology1.12753555
90MP0001545_abnormal_hematopoietic_system1.12248446
91MP0005397_hematopoietic_system_phenotyp1.12248446
92MP0005310_abnormal_salivary_gland1.12053228
93MP0002086_abnormal_extraembryonic_tissu1.12028410
94MP0002084_abnormal_developmental_patter1.09984887
95MP0000534_abnormal_ureter_morphology1.08388068
96MP0006054_spinal_hemorrhage1.06640121
97MP0003984_embryonic_growth_retardation1.06048974
98MP0002148_abnormal_hypersensitivity_rea1.05869666
99MP0002088_abnormal_embryonic_growth/wei1.05673886
100MP0001348_abnormal_lacrimal_gland1.05041322
101MP0000750_abnormal_muscle_regeneration1.04399574
102MP0001845_abnormal_inflammatory_respons1.02233390
103MP0002089_abnormal_postnatal_growth/wei1.02053959
104MP0005380_embryogenesis_phenotype1.01766214
105MP0001672_abnormal_embryogenesis/_devel1.01766214
106MP0009672_abnormal_birth_weight1.00421476
107MP0003091_abnormal_cell_migration1.00165225
108MP0003252_abnormal_bile_duct0.99148865
109MP0002254_reproductive_system_inflammat0.98453208
110MP0000759_abnormal_skeletal_muscle0.98399911
111MP0003646_muscle_fatigue0.98376611
112MP0010030_abnormal_orbit_morphology0.98334336
113MP0001697_abnormal_embryo_size0.97129263
114MP0002139_abnormal_hepatobiliary_system0.96125508
115MP0002161_abnormal_fertility/fecundity0.96084901
116MP0002925_abnormal_cardiovascular_devel0.95875160
117MP0001958_emphysema0.95614923
118MP0008770_decreased_survivor_rate0.94348781
119MP0002080_prenatal_lethality0.93118477
120MP0003119_abnormal_digestive_system0.92784244
121MP0002933_joint_inflammation0.92729510
122MP0005390_skeleton_phenotype0.91756803
123MP0000747_muscle_weakness0.91583656
124MP0003045_fibrosis0.90947141
125MP0005330_cardiomyopathy0.90611729
126MP0000266_abnormal_heart_morphology0.90152351
127MP0002085_abnormal_embryonic_tissue0.89857663
128MP0002909_abnormal_adrenal_gland0.89462733
129MP0002166_altered_tumor_susceptibility0.89119360
130MP0010368_abnormal_lymphatic_system0.88736002
131MP0005083_abnormal_biliary_tract0.88329481
132MP0003123_paternal_imprinting0.87173218
133MP0003329_amyloid_beta_deposits0.86836537
134MP0003448_altered_tumor_morphology0.86259194
135MP0004036_abnormal_muscle_relaxation0.85940595
136MP0003075_altered_response_to0.85333807
137MP0001853_heart_inflammation0.83851510
138MP0000685_abnormal_immune_system0.83434985
139MP0008469_abnormal_protein_level0.82605480
140MP0005621_abnormal_cell_physiology0.80486204
141MP0010329_abnormal_lipoprotein_level0.79834543
142MP0000350_abnormal_cell_proliferation0.79346544
143MP0000465_gastrointestinal_hemorrhage0.78901095
144MP0004858_abnormal_nervous_system0.78375519
145MP0002837_dystrophic_cardiac_calcinosis0.78127785
146MP0001915_intracranial_hemorrhage0.77910322
147MP0002128_abnormal_blood_circulation0.77343200
148MP0002009_preneoplasia0.76980005
149MP0003191_abnormal_cellular_cholesterol0.76755982
150MP0002396_abnormal_hematopoietic_system0.76533494
151MP0003111_abnormal_nucleus_morphology0.76390754
152MP0000428_abnormal_craniofacial_morphol0.76178700
153MP0004947_skin_inflammation0.76140738
154MP0000609_abnormal_liver_physiology0.74943053
155MP0003942_abnormal_urinary_system0.73744027
156MP0005377_hearing/vestibular/ear_phenot0.73634455
157MP0003878_abnormal_ear_physiology0.73634455
158MP0004510_myositis0.73393019
159MP0004272_abnormal_basement_membrane0.72898081
160MP0009115_abnormal_fat_cell0.72434582
161MP0002060_abnormal_skin_morphology0.71495178
162MP0002796_impaired_skin_barrier0.71258748
163MP0003183_abnormal_peptide_metabolism0.70820717
164MP0009931_abnormal_skin_appearance0.70695145
165MP0001663_abnormal_digestive_system0.68424281
166MP0000767_abnormal_smooth_muscle0.67863323
167MP0000604_amyloidosis0.67637993
168MP0005166_decreased_susceptibility_to0.67612161

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.49402050
2Nasal polyposis (HP:0100582)3.96852652
3Abnormality of the nasal mucosa (HP:0000433)3.73867139
4Protrusio acetabuli (HP:0003179)3.68559165
5Cerebral aneurysm (HP:0004944)3.54859568
6Hyperacusis (HP:0010780)3.50969285
7Recurrent abscess formation (HP:0002722)3.27862542
8Recurrent bacterial skin infections (HP:0005406)3.27010372
9Cellulitis (HP:0100658)3.13106334
10Abnormality of macrophages (HP:0004311)3.03762643
11Increased IgE level (HP:0003212)3.02974839
12Obstructive sleep apnea (HP:0002870)2.98541923
13Difficulty climbing stairs (HP:0003551)2.95777525
14Shallow orbits (HP:0000586)2.86339792
15Obstructive lung disease (HP:0006536)2.85760567
16Chronic obstructive pulmonary disease (HP:0006510)2.85760567
17Male infertility (HP:0003251)2.81063147
18Distal upper limb amyotrophy (HP:0007149)2.80769481
19Upper limb amyotrophy (HP:0009129)2.80769481
20Myositis (HP:0100614)2.77601520
21Gastrointestinal infarctions (HP:0005244)2.73714884
22Increased connective tissue (HP:0009025)2.70262770
23Gingivitis (HP:0000230)2.66698349
24Achilles tendon contracture (HP:0001771)2.66524966
25Abnormality of the lower motor neuron (HP:0002366)2.66023295
26Broad face (HP:0000283)2.62624992
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61101571
28Abnormality of the fingertips (HP:0001211)2.59684045
29Exercise-induced muscle cramps (HP:0003710)2.59415227
30Abnormality of the Achilles tendon (HP:0005109)2.59340091
31Hand muscle atrophy (HP:0009130)2.59254718
32Genu recurvatum (HP:0002816)2.55862523
33Colitis (HP:0002583)2.55166614
34Ulnar bowing (HP:0003031)2.54937292
35Disproportionate tall stature (HP:0001519)2.53914303
36Mitral valve prolapse (HP:0001634)2.53705831
37Renovascular hypertension (HP:0100817)2.51755708
38Renal duplication (HP:0000075)2.49127729
39Hyporeflexia of lower limbs (HP:0002600)2.48713677
40Lymphangioma (HP:0100764)2.47600869
41Gastrointestinal inflammation (HP:0004386)2.47591288
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.46826112
43Absent/shortened dynein arms (HP:0200106)2.46826112
44Mediastinal lymphadenopathy (HP:0100721)2.44934828
45Meningitis (HP:0001287)2.43838225
46Myoglobinuria (HP:0002913)2.42213673
47Orchitis (HP:0100796)2.41937599
48Elfin facies (HP:0004428)2.41688072
49Elevated erythrocyte sedimentation rate (HP:0003565)2.41304189
50Broad metatarsal (HP:0001783)2.40181810
51Bundle branch block (HP:0011710)2.39574504
52Rectal prolapse (HP:0002035)2.39396174
53Spontaneous hematomas (HP:0007420)2.38891737
54Recurrent fungal infections (HP:0002841)2.38675081
55Asymmetric septal hypertrophy (HP:0001670)2.38225895
56Infertility (HP:0000789)2.37368342
57Ankle contracture (HP:0006466)2.34926398
58Aneurysm (HP:0002617)2.34068803
59Difficulty running (HP:0009046)2.33989368
60Bladder diverticulum (HP:0000015)2.32337005
61Long toe (HP:0010511)2.32331285
62Insomnia (HP:0100785)2.31407869
63Exercise-induced myalgia (HP:0003738)2.28434103
64Recurrent gram-negative bacterial infections (HP:0005420)2.27752607
65Bowel diverticulosis (HP:0005222)2.27410214
66Dysmetric saccades (HP:0000641)2.24680426
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24054654
68Short 4th metacarpal (HP:0010044)2.24054654
69Enlarged penis (HP:0000040)2.23989034
70Premature rupture of membranes (HP:0001788)2.22757293
71Aortic aneurysm (HP:0004942)2.22504078
72Polygenic inheritance (HP:0010982)2.20102626
73Inflammation of the large intestine (HP:0002037)2.20065542
74Neoplasm of the heart (HP:0100544)2.19165275
75Type 1 muscle fiber predominance (HP:0003803)2.18074437
76Segmental peripheral demyelination/remyelination (HP:0003481)2.16116201
77Long palpebral fissure (HP:0000637)2.15949978
78Recurrent viral infections (HP:0004429)2.12440962
79Abnormality of the 4th metacarpal (HP:0010012)2.11635658
80Distal lower limb amyotrophy (HP:0008944)2.11321586
81Slow saccadic eye movements (HP:0000514)2.10955381
82Chronic bronchitis (HP:0004469)2.10775505
83Peritonitis (HP:0002586)2.09817967
84Deep venous thrombosis (HP:0002625)2.09695388
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08463863
86Metaphyseal cupping (HP:0003021)2.07375722
87Recurrent skin infections (HP:0001581)2.07183449
88Hallux valgus (HP:0001822)2.06262719
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.05652687
90Deviation of the hallux (HP:0010051)2.04508242
91Dilatation of the ascending aorta (HP:0005111)2.04181344
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.03571962
93Prolonged bleeding time (HP:0003010)2.02005075
94Increased density of long bones (HP:0006392)2.01644551
95Deep palmar crease (HP:0006191)1.99671282
96Hypertensive crisis (HP:0100735)1.99113165
97Mildly elevated creatine phosphokinase (HP:0008180)1.96671109
98Back pain (HP:0003418)1.96318284
99Fibroma (HP:0010614)1.96087716
100Abnormality of the thoracic spine (HP:0100711)1.94560510
101Ulnar deviation of the wrist (HP:0003049)1.94382706
102Polycythemia (HP:0001901)1.94156194
103Retrobulbar optic neuritis (HP:0100654)1.93817725
104Optic neuritis (HP:0100653)1.93817725
105Pustule (HP:0200039)1.93393717
106Heterotopia (HP:0002282)1.93077248
107Chest pain (HP:0100749)1.92134729
108Increased variability in muscle fiber diameter (HP:0003557)1.90716262
109EMG: neuropathic changes (HP:0003445)1.90508127
110Hypercortisolism (HP:0001578)1.90176706
111Thin bony cortex (HP:0002753)1.90168004
112Emphysema (HP:0002097)1.89947580
113Vertebral compression fractures (HP:0002953)1.87848498
114Overriding aorta (HP:0002623)1.87708507
115Adenoma sebaceum (HP:0009720)1.87214513
116Angiofibromas (HP:0010615)1.87214513
117Vasculitis (HP:0002633)1.85348276
118Urticaria (HP:0001025)1.84850523
119Gastrointestinal stroma tumor (HP:0100723)1.84734061
120Stridor (HP:0010307)1.84426817
121Fibrous tissue neoplasm (HP:0012316)1.83966956
122Hypochromic anemia (HP:0001931)1.83671900
123Bronchitis (HP:0012387)1.81637973
124Pointed chin (HP:0000307)1.81158010
125Right ventricular cardiomyopathy (HP:0011663)1.81127972
126Chronic mucocutaneous candidiasis (HP:0002728)1.80241172
127Recurrent cutaneous fungal infections (HP:0011370)1.80241172
128Abnormality of the peritoneum (HP:0002585)1.79598696
129Spinal cord lesions (HP:0100561)1.79532294
130Syringomyelia (HP:0003396)1.79532294
131Thoracic kyphosis (HP:0002942)1.79515140
132Viral hepatitis (HP:0006562)1.79274755
133Ependymoma (HP:0002888)1.79202968
134Easy fatigability (HP:0003388)1.78386610
135Dislocated radial head (HP:0003083)1.77868260
136Buphthalmos (HP:0000557)1.77652738
137Hemorrhage of the eye (HP:0011885)1.77053456
138Panhypogammaglobulinemia (HP:0003139)1.76759075
139Osteomyelitis (HP:0002754)1.76717838
140Subacute progressive viral hepatitis (HP:0006572)1.75186304
141Abnormality of skeletal muscle fiber size (HP:0012084)1.74459410
142Bowed forearm bones (HP:0003956)1.73463515
143Bowing of the arm (HP:0006488)1.73463515
144Sudden death (HP:0001699)1.72941955
145Flat acetabular roof (HP:0003180)1.71714097
146Flat cornea (HP:0007720)1.71681640
147Frequent falls (HP:0002359)1.70830771
148Milia (HP:0001056)1.70429984
149Supernumerary nipples (HP:0002558)1.70328751
150Hypertriglyceridemia (HP:0002155)1.70197722
151Distal lower limb muscle weakness (HP:0009053)1.68385425
152High pitched voice (HP:0001620)1.67564779
153Fatigue (HP:0012378)1.67447200
154Turricephaly (HP:0000262)1.67359805
155Limb-girdle muscle atrophy (HP:0003797)1.67215121
156Rhabdomyolysis (HP:0003201)1.66938785
157Striae distensae (HP:0001065)1.66615741
158Seborrheic dermatitis (HP:0001051)1.66378748
159Annular pancreas (HP:0001734)1.66227617
160Mitral regurgitation (HP:0001653)1.65768591
161Papilloma (HP:0012740)1.65208059
162Verrucae (HP:0200043)1.65208059
163Epistaxis (HP:0000421)1.65132875
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.64704347
165Bowel incontinence (HP:0002607)1.64423251
166Fragile skin (HP:0001030)1.64146897
167Cervical subluxation (HP:0003308)1.64104642
168Macroorchidism (HP:0000053)1.64075557
169Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63818970
170Interstitial pulmonary disease (HP:0006530)1.63038440
171Aortic dissection (HP:0002647)1.62761038
172Hamartoma of the eye (HP:0010568)1.62574983
173Recurrent bronchitis (HP:0002837)1.62212951
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.61845377
175Encephalitis (HP:0002383)1.60747973
176Atrophic scars (HP:0001075)1.60691523
177Short phalanx of the thumb (HP:0009660)1.60243449
178Abnormality of the radial head (HP:0003995)1.60128632
179Abnormal vertebral ossification (HP:0100569)1.60007524
180Lymphopenia (HP:0001888)1.59690263
181Bicuspid aortic valve (HP:0001647)1.59133805
182Basal cell carcinoma (HP:0002671)1.58388038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.96784086
2PKN24.15554425
3EEF2K3.89225722
4PRPF4B3.88232734
5MAP3K103.65783721
6ICK3.21205688
7PRKD33.19534563
8SMG13.14167702
9TESK12.62866888
10RIPK42.57543777
11PDK42.44986576
12PDK32.44986576
13TTN2.19112626
14ERN12.01628713
15RIPK11.85840315
16MAP3K131.75276236
17PTK61.72132112
18IRAK41.66652384
19TYK21.65432938
20PDGFRA1.64251440
21NEK21.60614856
22IRAK31.55788497
23LRRK21.50078078
24CDK121.46487634
25TYRO31.37185630
26TAOK11.37136835
27FES1.35737734
28SIK11.33894235
29CSK1.33651646
30TNK21.29246027
31MAP4K11.28608281
32BMX1.28274701
33STK381.26335046
34DYRK1B1.24404390
35ALK1.23759490
36BLK1.21672357
37TAOK21.18562773
38PAK41.16114412
39JAK31.15944879
40PDK21.14554618
41MAP3K141.11386827
42MTOR1.10311111
43LATS21.09212703
44STK101.08636691
45BTK1.08518568
46SIK31.06800476
47GRK61.03669657
48CDC42BPA1.03005197
49KSR21.02527668
50MAP3K71.01890251
51SCYL21.00063547
52FGFR40.98359314
53TBK10.98187821
54DDR20.96823259
55HCK0.95504726
56NEK10.94960280
57CAMKK10.91969749
58DMPK0.91795406
59PAK20.90943918
60PTK2B0.88705099
61FLT30.86265445
62LATS10.85822878
63NME20.85624650
64IRAK20.85532846
65CDK60.84443699
66PDK10.82638905
67CDK40.81834801
68LMTK20.79837723
69RET0.79646477
70MAP2K30.78484388
71CAMK1G0.76952755
72MAP3K80.75214414
73MAPKAPK30.73565746
74PTK20.72337682
75ILK0.69605846
76ARAF0.69592772
77EPHB10.68339000
78MAPK120.66850809
79RPS6KB20.65754161
80SIK20.65403157
81PDPK10.64807262
82PDGFRB0.64125578
83IKBKE0.63211718
84BRAF0.62574341
85PAK60.62002636
86PRKCH0.61865312
87MAP3K60.61660685
88BRD40.61264091
89CAMK1D0.60163048
90FGR0.59246408
91MAP3K110.58825596
92STK30.57644971
93RPS6KA60.57286258
94MARK20.57255896
95ITK0.56209149
96ZAP700.55668762
97PASK0.55537478
98SYK0.55360630
99PRKD20.54845888
100MAP3K90.54640870
101LCK0.52710440
102CSF1R0.50618908
103TESK20.50239340
104RPS6KA40.48375174
105TGFBR20.48308369
106BCKDK0.48152302
107RPS6KA10.46894255
108TGFBR10.45738878
109PRKG20.44754998
110MAP2K20.44562886
111LYN0.44400868
112FGFR10.44321198
113SGK30.44173744
114MAPK110.43276186
115MARK30.42943228
116CDK70.42670499
117MAP3K20.41553764
118FGFR30.40831540
119PRKD10.40649927
120MAPK70.40545821
121MOS0.40448904
122DAPK20.39930820
123MAP3K10.38771276
124DAPK30.38555161
125RPS6KA20.38518402
126JAK20.34638262
127EPHA20.34571702
128CDC70.33446724
129MAP3K30.33437906
130STK110.31907768
131WNK40.31588843
132PAK10.28265421
133PIM10.28158265
134EPHB20.28081982
135TTK0.27627274
136HIPK20.27589926
137WNK10.27130347
138JAK10.25848298
139RPS6KL10.25718177
140RPS6KC10.25718177

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.39096372
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32783465
3Osteoclast differentiation_Homo sapiens_hsa043802.09903897
4Other glycan degradation_Homo sapiens_hsa005111.94928470
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.91125746
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81236572
7Leishmaniasis_Homo sapiens_hsa051401.80939039
8Fatty acid biosynthesis_Homo sapiens_hsa000611.80450716
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71842629
10Central carbon metabolism in cancer_Homo sapiens_hsa052301.65437024
11Chronic myeloid leukemia_Homo sapiens_hsa052201.61494682
12mTOR signaling pathway_Homo sapiens_hsa041501.58678764
13Glucagon signaling pathway_Homo sapiens_hsa049221.54338386
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52606168
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49274785
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47457289
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47220230
18VEGF signaling pathway_Homo sapiens_hsa043701.45571383
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44515249
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36559714
21Insulin resistance_Homo sapiens_hsa049311.36508104
22Biosynthesis of amino acids_Homo sapiens_hsa012301.33855479
23Influenza A_Homo sapiens_hsa051641.30816285
24Bladder cancer_Homo sapiens_hsa052191.30712841
25Fatty acid degradation_Homo sapiens_hsa000711.28673548
26Hepatitis B_Homo sapiens_hsa051611.27415445
27Carbon metabolism_Homo sapiens_hsa012001.26727842
28Measles_Homo sapiens_hsa051621.26325840
29Non-small cell lung cancer_Homo sapiens_hsa052231.25441541
30Tuberculosis_Homo sapiens_hsa051521.25211662
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24129660
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23460474
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.23283583
34Lysine degradation_Homo sapiens_hsa003101.23092985
35Acute myeloid leukemia_Homo sapiens_hsa052211.22998945
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.21968889
37Arginine biosynthesis_Homo sapiens_hsa002201.20399630
38Focal adhesion_Homo sapiens_hsa045101.20087326
39PPAR signaling pathway_Homo sapiens_hsa033201.19184919
40Proteoglycans in cancer_Homo sapiens_hsa052051.19116307
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19106000
42Estrogen signaling pathway_Homo sapiens_hsa049151.19093233
43Glioma_Homo sapiens_hsa052141.18462913
44AMPK signaling pathway_Homo sapiens_hsa041521.17338626
45Primary immunodeficiency_Homo sapiens_hsa053401.16839988
46Chemokine signaling pathway_Homo sapiens_hsa040621.15767065
47Bile secretion_Homo sapiens_hsa049761.15605467
48Insulin signaling pathway_Homo sapiens_hsa049101.15201948
49Selenocompound metabolism_Homo sapiens_hsa004501.15159945
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13907802
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13568139
52TNF signaling pathway_Homo sapiens_hsa046681.13127903
53Herpes simplex infection_Homo sapiens_hsa051681.11913467
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.11718683
55Hepatitis C_Homo sapiens_hsa051601.11477746
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10459611
57Endometrial cancer_Homo sapiens_hsa052131.08324140
58ErbB signaling pathway_Homo sapiens_hsa040121.07947494
59Apoptosis_Homo sapiens_hsa042101.05504057
60B cell receptor signaling pathway_Homo sapiens_hsa046621.05295441
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05132116
62Adherens junction_Homo sapiens_hsa045201.03331544
63Choline metabolism in cancer_Homo sapiens_hsa052311.03047843
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02931873
65Fat digestion and absorption_Homo sapiens_hsa049751.00982715
66Pyruvate metabolism_Homo sapiens_hsa006201.00840235
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00380805
68GnRH signaling pathway_Homo sapiens_hsa049120.98277709
69Malaria_Homo sapiens_hsa051440.97425206
70Dorso-ventral axis formation_Homo sapiens_hsa043200.96689485
71Small cell lung cancer_Homo sapiens_hsa052220.96133173
72Staphylococcus aureus infection_Homo sapiens_hsa051500.95865390
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.95787265
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94830482
75Shigellosis_Homo sapiens_hsa051310.94677451
76Inositol phosphate metabolism_Homo sapiens_hsa005620.94226690
77Allograft rejection_Homo sapiens_hsa053300.93753738
78HIF-1 signaling pathway_Homo sapiens_hsa040660.92916776
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92730174
80Prostate cancer_Homo sapiens_hsa052150.92722405
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92255694
82Graft-versus-host disease_Homo sapiens_hsa053320.91474967
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88832136
84Prion diseases_Homo sapiens_hsa050200.87636710
85Thyroid cancer_Homo sapiens_hsa052160.87499756
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.87298207
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86741888
88Fatty acid metabolism_Homo sapiens_hsa012120.86107030
89Autoimmune thyroid disease_Homo sapiens_hsa053200.85295163
90Notch signaling pathway_Homo sapiens_hsa043300.85048968
91Basal cell carcinoma_Homo sapiens_hsa052170.84623036
92Hippo signaling pathway_Homo sapiens_hsa043900.83441002
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.81515571
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.81461134
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80947080
96Dilated cardiomyopathy_Homo sapiens_hsa054140.79889849
97Pentose phosphate pathway_Homo sapiens_hsa000300.79816712
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79146737
99Sulfur relay system_Homo sapiens_hsa041220.77630085
100Type II diabetes mellitus_Homo sapiens_hsa049300.77546616
101Glycerolipid metabolism_Homo sapiens_hsa005610.77377104
102Salmonella infection_Homo sapiens_hsa051320.76810895
103mRNA surveillance pathway_Homo sapiens_hsa030150.76066182
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74608888
105FoxO signaling pathway_Homo sapiens_hsa040680.74606928
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.73789670
107Epstein-Barr virus infection_Homo sapiens_hsa051690.73613312
108Endocytosis_Homo sapiens_hsa041440.73211087
109Protein digestion and absorption_Homo sapiens_hsa049740.72829844
110MicroRNAs in cancer_Homo sapiens_hsa052060.72310260
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72183820
112Hematopoietic cell lineage_Homo sapiens_hsa046400.71435354
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71066123
114MAPK signaling pathway_Homo sapiens_hsa040100.71063148
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70936710
116Pancreatic cancer_Homo sapiens_hsa052120.70903033
117HTLV-I infection_Homo sapiens_hsa051660.70139944
118Viral myocarditis_Homo sapiens_hsa054160.69787537
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69628037
120Propanoate metabolism_Homo sapiens_hsa006400.69601054
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.69171311
122Long-term potentiation_Homo sapiens_hsa047200.69009326
123Renal cell carcinoma_Homo sapiens_hsa052110.67346719
124Fructose and mannose metabolism_Homo sapiens_hsa000510.67320194
125Amoebiasis_Homo sapiens_hsa051460.67042599
126Antigen processing and presentation_Homo sapiens_hsa046120.66957457
127Platelet activation_Homo sapiens_hsa046110.66545479
128Oocyte meiosis_Homo sapiens_hsa041140.66188730
129Toxoplasmosis_Homo sapiens_hsa051450.65894008
130Colorectal cancer_Homo sapiens_hsa052100.64545476
131Tight junction_Homo sapiens_hsa045300.64538205
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64196177
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63963881
134Prolactin signaling pathway_Homo sapiens_hsa049170.63883646
135ECM-receptor interaction_Homo sapiens_hsa045120.63478392
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62952216
137Viral carcinogenesis_Homo sapiens_hsa052030.61958758
138Gastric acid secretion_Homo sapiens_hsa049710.60240990
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59567624
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59471060
141T cell receptor signaling pathway_Homo sapiens_hsa046600.57399126
142African trypanosomiasis_Homo sapiens_hsa051430.57283454
143Legionellosis_Homo sapiens_hsa051340.56250212
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56009403
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55066748
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54647727
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54606714
148Rap1 signaling pathway_Homo sapiens_hsa040150.54008367
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.53838884

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