CSNK2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.75839097
2axon ensheathment in central nervous system (GO:0032291)4.75839097
3establishment of integrated proviral latency (GO:0075713)4.30910647
4protein localization to kinetochore (GO:0034501)3.98663409
5cytoplasmic mRNA processing body assembly (GO:0033962)3.87899635
6fatty acid elongation (GO:0030497)3.81896437
7protein localization to chromosome, centromeric region (GO:0071459)3.75989102
8ribosome assembly (GO:0042255)3.75857046
9mitotic metaphase plate congression (GO:0007080)3.70262262
10pore complex assembly (GO:0046931)3.69861015
11mitotic sister chromatid segregation (GO:0000070)3.68936159
12sister chromatid segregation (GO:0000819)3.67973125
13mitotic chromosome condensation (GO:0007076)3.63430200
14regulation of posttranscriptional gene silencing (GO:0060147)3.63229766
15regulation of gene silencing by miRNA (GO:0060964)3.63229766
16regulation of gene silencing by RNA (GO:0060966)3.63229766
17DNA strand elongation involved in DNA replication (GO:0006271)3.56790830
18axon ensheathment (GO:0008366)3.55003610
19ensheathment of neurons (GO:0007272)3.55003610
20cell fate commitment involved in formation of primary germ layer (GO:0060795)3.53604958
21myelination (GO:0042552)3.52221643
22anterior/posterior axis specification, embryo (GO:0008595)3.49949595
23establishment of mitochondrion localization (GO:0051654)3.49348941
24IMP biosynthetic process (GO:0006188)3.45476932
25regulation of RNA export from nucleus (GO:0046831)3.45311661
26DNA strand elongation (GO:0022616)3.42046226
27mitotic nuclear envelope disassembly (GO:0007077)3.41546576
28asymmetric protein localization (GO:0008105)3.39552353
29formation of translation preinitiation complex (GO:0001731)3.39201514
30non-recombinational repair (GO:0000726)3.37942699
31double-strand break repair via nonhomologous end joining (GO:0006303)3.37942699
32IMP metabolic process (GO:0046040)3.34424572
33heterochromatin organization (GO:0070828)3.34368374
34cell migration in hindbrain (GO:0021535)3.30643164
35layer formation in cerebral cortex (GO:0021819)3.28571129
36apical protein localization (GO:0045176)3.27737977
37membrane disassembly (GO:0030397)3.24583480
38nuclear envelope disassembly (GO:0051081)3.24583480
39DNA replication checkpoint (GO:0000076)3.24056971
40metaphase plate congression (GO:0051310)3.23122278
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.22129968
42pre-miRNA processing (GO:0031054)3.20837511
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19365318
44chromatin remodeling at centromere (GO:0031055)3.18914499
45CENP-A containing nucleosome assembly (GO:0034080)3.18757920
46DNA topological change (GO:0006265)3.16788758
47protein complex localization (GO:0031503)3.15247351
48nuclear pore complex assembly (GO:0051292)3.13229153
49protein localization to endosome (GO:0036010)3.07346307
50regulation of chromosome segregation (GO:0051983)3.06757322
51cholesterol biosynthetic process (GO:0006695)3.05164376
52telomere maintenance via semi-conservative replication (GO:0032201)3.03281429
53regulation of centriole replication (GO:0046599)3.02557220
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02469799
55establishment of viral latency (GO:0019043)2.97676323
56DNA double-strand break processing (GO:0000729)2.97665823
57ATP-dependent chromatin remodeling (GO:0043044)2.96791098
58histone exchange (GO:0043486)2.96098214
59presynaptic membrane assembly (GO:0097105)2.94738632
60DNA replication-independent nucleosome assembly (GO:0006336)2.94429594
61DNA replication-independent nucleosome organization (GO:0034724)2.94429594
62ribosomal small subunit biogenesis (GO:0042274)2.94283625
63DNA replication initiation (GO:0006270)2.93152773
64positive regulation of dendritic spine morphogenesis (GO:0061003)2.92445309
65DNA ligation (GO:0006266)2.91554890
66* spindle checkpoint (GO:0031577)2.90796296
67nuclear pore organization (GO:0006999)2.89479924
68regulation of histone H3-K9 methylation (GO:0051570)2.88340131
69polarized epithelial cell differentiation (GO:0030859)2.88211317
70negative regulation of histone methylation (GO:0031061)2.87797902
71lateral sprouting from an epithelium (GO:0060601)2.87037925
72DNA duplex unwinding (GO:0032508)2.86105492
73neuronal stem cell maintenance (GO:0097150)2.84200183
74negative regulation of chromosome segregation (GO:0051985)2.81960353
75regulation of nucleobase-containing compound transport (GO:0032239)2.81826309
76myelin maintenance (GO:0043217)2.81428233
77DNA geometric change (GO:0032392)2.80159596
78establishment of chromosome localization (GO:0051303)2.80141961
79establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.79439075
80mitochondrion transport along microtubule (GO:0047497)2.79439075
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78424961
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78424961
83negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78424961
84negative regulation of mitotic sister chromatid separation (GO:2000816)2.78424961
85negative regulation of sister chromatid segregation (GO:0033046)2.78424961
86purine nucleobase biosynthetic process (GO:0009113)2.78088272
87tRNA aminoacylation for protein translation (GO:0006418)2.77804994
88L-serine metabolic process (GO:0006563)2.77251842
89regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76241551
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76241551
91* mitotic spindle checkpoint (GO:0071174)2.74849781
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74309677
93regulation of DNA endoreduplication (GO:0032875)2.74051041
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.73074133
95DNA unwinding involved in DNA replication (GO:0006268)2.72808532
96regulation of mitotic sister chromatid separation (GO:0010965)2.72591005
97regulation of mitotic sister chromatid segregation (GO:0033047)2.72591005
98regulation of sister chromatid segregation (GO:0033045)2.72591005
99histone H2B ubiquitination (GO:0033523)2.72551939
100dendritic spine morphogenesis (GO:0060997)2.71902836
101long-chain fatty acid biosynthetic process (GO:0042759)2.71215969
102tRNA aminoacylation (GO:0043039)2.71199591
103amino acid activation (GO:0043038)2.71199591
104DNA damage response, detection of DNA damage (GO:0042769)2.69140540
105cellular protein complex localization (GO:0034629)2.67541274
106mitotic recombination (GO:0006312)2.67163059
107viral transcription (GO:0019083)2.64833448
108chromatin assembly (GO:0031497)2.64610404
109regulation of mitotic spindle organization (GO:0060236)2.64550251
110mitotic spindle assembly checkpoint (GO:0007094)2.64423293
111mitotic sister chromatid cohesion (GO:0007064)2.62868961
112nucleobase biosynthetic process (GO:0046112)2.62632377
113spindle assembly checkpoint (GO:0071173)2.61931179
114limb bud formation (GO:0060174)2.61787776
115negative regulation of mRNA processing (GO:0050686)2.61535242
116negative regulation of mRNA metabolic process (GO:1903312)2.61433478
117telomere maintenance via recombination (GO:0000722)2.60602720
118translational termination (GO:0006415)2.60364213
119protein localization to chromosome (GO:0034502)2.58884145
120presynaptic membrane organization (GO:0097090)2.57419457
121sterol biosynthetic process (GO:0016126)2.56352520
122ectodermal placode formation (GO:0060788)2.56330060
123regulation of catenin import into nucleus (GO:0035412)2.55997734
124regulation of mRNA 3-end processing (GO:0031440)2.55985792
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.54388997
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54388997
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54388997
128glycerophospholipid catabolic process (GO:0046475)2.54185952
129DNA conformation change (GO:0071103)2.54073906
130positive regulation of cell cycle checkpoint (GO:1901978)2.53248122
131positive regulation of oligodendrocyte differentiation (GO:0048714)2.50930535
132chromosome condensation (GO:0030261)2.50684283
133negative regulation of neurotransmitter secretion (GO:0046929)2.49787678
134mRNA transport (GO:0051028)2.49663103
135chromosome segregation (GO:0007059)2.49323041
136nuclear envelope organization (GO:0006998)2.49185984
137regulation of centrosome cycle (GO:0046605)2.48986879
138regulation of histone H3-K27 methylation (GO:0061085)2.48602848
139kinetochore organization (GO:0051383)2.48362855
140chromatin assembly or disassembly (GO:0006333)2.47171311
141regulation of spindle organization (GO:0090224)2.46958254
142spindle assembly involved in mitosis (GO:0090307)2.46486220
143positive regulation of neurological system process (GO:0031646)2.45988377
144neuron cell-cell adhesion (GO:0007158)2.45363310
145folic acid-containing compound biosynthetic process (GO:0009396)2.44789854
146DNA strand renaturation (GO:0000733)2.44668405
147long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43125778
148regulation of dendritic spine morphogenesis (GO:0061001)2.40914318
149hippo signaling (GO:0035329)2.40708638
150negative regulation of DNA repair (GO:0045738)2.40592694
151positive regulation of catenin import into nucleus (GO:0035413)2.40590334
152regulation of sister chromatid cohesion (GO:0007063)2.39577201
153Leydig cell differentiation (GO:0033327)2.37979951
154negative regulation of potassium ion transmembrane transport (GO:1901380)2.35786096
155DNA replication-dependent nucleosome assembly (GO:0006335)2.35614579
156DNA replication-dependent nucleosome organization (GO:0034723)2.35614579
157enteric nervous system development (GO:0048484)2.34335960
158paraxial mesoderm development (GO:0048339)2.32438058
159regulation of histone methylation (GO:0031060)2.31322205
160histone lysine demethylation (GO:0070076)2.30604219
161establishment of apical/basal cell polarity (GO:0035089)2.29929518
162histone monoubiquitination (GO:0010390)2.28749025
163positive regulation of dendritic spine development (GO:0060999)2.27481875
164neuron recognition (GO:0008038)2.24947561
165axonal fasciculation (GO:0007413)2.24829262
166peripheral nervous system axon ensheathment (GO:0032292)2.24328268
167myelination in peripheral nervous system (GO:0022011)2.24328268
168fatty-acyl-CoA biosynthetic process (GO:0046949)2.24312014
169anterior/posterior axis specification (GO:0009948)2.22576896
170cranial nerve development (GO:0021545)2.22267329
171regulation of gene expression by genetic imprinting (GO:0006349)2.22174586
172positive regulation of chromosome segregation (GO:0051984)2.19807182
173regulation of helicase activity (GO:0051095)2.19791201
174regulation of myelination (GO:0031641)2.19401126
175short-term memory (GO:0007614)2.19275060
176astrocyte development (GO:0014002)2.19179485
177positive regulation of neuroblast proliferation (GO:0002052)2.18635970
178nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.17940876
179negative regulation of neurotransmitter transport (GO:0051589)2.17624120
180long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.16947301
181substantia nigra development (GO:0021762)2.16465733
182positive regulation of SMAD protein import into nucleus (GO:0060391)2.16346070
183establishment of monopolar cell polarity (GO:0061162)2.15794019
184establishment or maintenance of monopolar cell polarity (GO:0061339)2.15794019
185regulation of dendritic spine development (GO:0060998)2.15772157
186regulation of translational fidelity (GO:0006450)2.14852135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.12963244
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.46821220
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.30793663
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29555576
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11178322
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.58678239
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.57935521
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55736222
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52922713
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39254670
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36719166
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29129314
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26925645
14E2F7_22180533_ChIP-Seq_HELA_Human2.26878846
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.20831565
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.19847400
17* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17968067
18* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17968067
19* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17968067
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17826920
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.17676292
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.17105392
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17058159
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15061138
25ELK1_19687146_ChIP-ChIP_HELA_Human2.14148576
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13821705
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10261596
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.07963291
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07448884
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05989802
31STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse2.03458884
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02511582
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02070474
34TAF15_26573619_Chip-Seq_HEK293_Human2.00915543
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96011406
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92972124
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91013226
38* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.90975618
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89489795
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87707658
41FUS_26573619_Chip-Seq_HEK293_Human1.84210951
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80333744
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79859176
44ZNF263_19887448_ChIP-Seq_K562_Human1.76335632
45* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74074764
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72129983
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.72039495
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71711924
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71232829
50SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69818130
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69653574
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.68784926
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66240390
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64603220
55DCP1A_22483619_ChIP-Seq_HELA_Human1.64449188
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63413717
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59053143
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58573937
59TTF2_22483619_ChIP-Seq_HELA_Human1.56795052
60XRN2_22483619_ChIP-Seq_HELA_Human1.55039361
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54434917
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52169664
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51632824
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51162123
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50439155
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49512738
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.48898856
68TP53_16413492_ChIP-PET_HCT116_Human1.48788896
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47460950
70* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47443993
71AR_21572438_ChIP-Seq_LNCaP_Human1.45891059
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44470974
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40449278
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40185438
75CLOCK_20551151_ChIP-Seq_293T_Human1.40077491
76* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39467929
77TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37991985
78POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.37483566
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.37307600
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32113862
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30956449
82* GABP_19822575_ChIP-Seq_HepG2_Human1.30709700
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28172777
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27671821
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.26905026
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.26126908
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.25554146
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24195094
89EWS_26573619_Chip-Seq_HEK293_Human1.23252961
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.21383336
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20753504
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.19339564
93* FOXP3_21729870_ChIP-Seq_TREG_Human1.18500253
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17255828
95* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17096237
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16937076
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16865389
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.16805689
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16715328
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.15429165
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14466600
102GBX2_23144817_ChIP-Seq_PC3_Human1.14348438
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.13218728
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12245898
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11617917
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.11287700
107VDR_23849224_ChIP-Seq_CD4+_Human1.10802989
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10625276
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09203311
110* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08630536
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.08525666
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07661092
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07573540
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06494369
115KDM5A_27292631_Chip-Seq_BREAST_Human1.04470308
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04249858
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02843664
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02608727
119* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01779250
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01681393
121MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00766729
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.00256057
123AR_21909140_ChIP-Seq_LNCAP_Human1.00163767
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99830777
125AHR_22903824_ChIP-Seq_MCF-7_Human0.99736124
126MYC_18940864_ChIP-ChIP_HL60_Human0.99468858
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99357755
128* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99203640
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99184525
130IRF1_19129219_ChIP-ChIP_H3396_Human0.98911699
131TRIM28_21343339_ChIP-Seq_HEK293_Human0.98865497
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98598653
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97840093
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95053089
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.94142588
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93318493
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92165504
138RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92165504
139* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92106382
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.91213973
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91022515
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.90817812
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.89532625
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89466470
145CHD1_26751641_Chip-Seq_LNCaP_Human0.89324537
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89147595
147POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.89133835
148CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88742592
149* STAT3_23295773_ChIP-Seq_U87_Human0.87893964
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.87555533
151* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86731247
152NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86464349
153TCF4_18268006_ChIP-ChIP_LS174T_Human0.85935381
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85289088
155ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84688697
156* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83570012
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82662024
158SOX9_26525672_Chip-Seq_HEART_Mouse0.81684770
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81027103
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77654913
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77452602
162* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76372546
163* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75815942
164YY1_21170310_ChIP-Seq_MESCs_Mouse0.75448459
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74433767
166SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73103414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.51028745
2MP0010094_abnormal_chromosome_stability3.37798941
3MP0003693_abnormal_embryo_hatching3.27285161
4MP0010234_abnormal_vibrissa_follicle3.24563248
5MP0003111_abnormal_nucleus_morphology3.09699228
6MP0009379_abnormal_foot_pigmentation2.84310859
7MP0004185_abnormal_adipocyte_glucose2.73647885
8MP0003077_abnormal_cell_cycle2.56746137
9MP0008058_abnormal_DNA_repair2.51367002
10MP0000537_abnormal_urethra_morphology2.29081276
11MP0005623_abnormal_meninges_morphology2.28830429
12MP0004270_analgesia2.28712763
13MP0010678_abnormal_skin_adnexa2.20250388
14* MP0003937_abnormal_limbs/digits/tail_de2.11534072
15MP0010352_gastrointestinal_tract_polyps2.09587408
16MP0000778_abnormal_nervous_system2.05444038
17MP0003880_abnormal_central_pattern2.02704169
18MP0002796_impaired_skin_barrier1.93605031
19MP0003950_abnormal_plasma_membrane1.87575955
20MP0002009_preneoplasia1.85468860
21MP0008007_abnormal_cellular_replicative1.81809251
22MP0004885_abnormal_endolymph1.79623906
23MP0009697_abnormal_copulation1.78724907
24MP0000920_abnormal_myelination1.70948634
25MP0003984_embryonic_growth_retardation1.62621957
26MP0005187_abnormal_penis_morphology1.61334218
27MP0000462_abnormal_digestive_system1.59935410
28MP0002088_abnormal_embryonic_growth/wei1.57834269
29MP0002084_abnormal_developmental_patter1.53242671
30MP0005666_abnormal_adipose_tissue1.53060513
31MP0006072_abnormal_retinal_apoptosis1.51583658
32* MP0003861_abnormal_nervous_system1.47888907
33MP0001485_abnormal_pinna_reflex1.46930439
34MP0000383_abnormal_hair_follicle1.46389361
35MP0010030_abnormal_orbit_morphology1.44887799
36MP0003122_maternal_imprinting1.44669272
37MP0003890_abnormal_embryonic-extraembry1.44408417
38MP0002697_abnormal_eye_size1.43130610
39MP0004381_abnormal_hair_follicle1.41211941
40* MP0002080_prenatal_lethality1.38154972
41MP0001730_embryonic_growth_arrest1.34843576
42MP0003567_abnormal_fetal_cardiomyocyte1.34825507
43MP0003119_abnormal_digestive_system1.34490436
44MP0009053_abnormal_anal_canal1.33946810
45MP0003755_abnormal_palate_morphology1.31238217
46MP0001299_abnormal_eye_distance/1.31100957
47MP0000762_abnormal_tongue_morphology1.30442642
48MP0004197_abnormal_fetal_growth/weight/1.30130416
49* MP0002085_abnormal_embryonic_tissue1.30085868
50MP0000467_abnormal_esophagus_morphology1.27831608
51MP0002086_abnormal_extraembryonic_tissu1.27549135
52MP0000647_abnormal_sebaceous_gland1.26415528
53MP0003385_abnormal_body_wall1.25247596
54MP0003941_abnormal_skin_development1.23808797
55MP0000428_abnormal_craniofacial_morphol1.21440490
56MP0001661_extended_life_span1.21297863
57MP0004145_abnormal_muscle_electrophysio1.21218838
58MP0005501_abnormal_skin_physiology1.19456897
59MP0003315_abnormal_perineum_morphology1.19415353
60MP0002751_abnormal_autonomic_nervous1.19262633
61MP0001340_abnormal_eyelid_morphology1.18266774
62MP0000747_muscle_weakness1.16832670
63MP0002092_abnormal_eye_morphology1.16702281
64MP0010307_abnormal_tumor_latency1.15826814
65MP0008877_abnormal_DNA_methylation1.12964513
66MP0000733_abnormal_muscle_development1.12629240
67MP0002877_abnormal_melanocyte_morpholog1.12621499
68MP0004233_abnormal_muscle_weight1.09199995
69MP0003632_abnormal_nervous_system1.07612223
70MP0003705_abnormal_hypodermis_morpholog1.06411551
71MP0004742_abnormal_vestibular_system1.05253355
72MP0008057_abnormal_DNA_replication1.05023396
73* MP0000432_abnormal_head_morphology1.04705455
74* MP0003935_abnormal_craniofacial_develop1.03695240
75MP0004272_abnormal_basement_membrane1.03235009
76MP0000579_abnormal_nail_morphology1.02592861
77MP0001529_abnormal_vocalization1.01974610
78MP0000955_abnormal_spinal_cord1.00661403
79* MP0002152_abnormal_brain_morphology1.00251053
80MP0009250_abnormal_appendicular_skeleto0.99967262
81MP0001293_anophthalmia0.99907002
82MP0006292_abnormal_olfactory_placode0.99408302
83MP0000566_synostosis0.99195957
84MP0003942_abnormal_urinary_system0.97989437
85MP0001348_abnormal_lacrimal_gland0.97408314
86* MP0003938_abnormal_ear_development0.97147878
87MP0005375_adipose_tissue_phenotype0.97127083
88MP0005409_darkened_coat_color0.96782636
89MP0005076_abnormal_cell_differentiation0.96734381
90MP0000377_abnormal_hair_follicle0.96435547
91MP0002111_abnormal_tail_morphology0.95685631
92MP0004133_heterotaxia0.95109504
93MP0008932_abnormal_embryonic_tissue0.94075774
94MP0002233_abnormal_nose_morphology0.93851962
95MP0004264_abnormal_extraembryonic_tissu0.93560138
96MP0001915_intracranial_hemorrhage0.93470150
97MP0003121_genomic_imprinting0.93441857
98MP0001346_abnormal_lacrimal_gland0.92993347
99MP0005408_hypopigmentation0.92878501
100* MP0001286_abnormal_eye_development0.90701941
101MP0002752_abnormal_somatic_nervous0.90424382
102MP0005380_embryogenesis_phenotype0.90238640
103MP0001672_abnormal_embryogenesis/_devel0.90238640
104MP0002081_perinatal_lethality0.90037344
105MP0005451_abnormal_body_composition0.89930915
106MP0009703_decreased_birth_body0.88850954
107MP0003283_abnormal_digestive_organ0.88771053
108MP0003634_abnormal_glial_cell0.88770151
109MP0001849_ear_inflammation0.88759023
110MP0001188_hyperpigmentation0.88088969
111MP0002938_white_spotting0.87572495
112MP0001697_abnormal_embryo_size0.87355632
113MP0000350_abnormal_cell_proliferation0.86867921
114MP0002234_abnormal_pharynx_morphology0.86433937
115MP0002102_abnormal_ear_morphology0.86264234
116MP0004957_abnormal_blastocyst_morpholog0.86237089
117MP0001486_abnormal_startle_reflex0.86120652
118MP0002249_abnormal_larynx_morphology0.85789048
119MP0009672_abnormal_birth_weight0.85235756
120MP0002837_dystrophic_cardiac_calcinosis0.84874561
121MP0000631_abnormal_neuroendocrine_gland0.84793970
122MP0008789_abnormal_olfactory_epithelium0.84689396
123MP0003221_abnormal_cardiomyocyte_apopto0.83361268
124MP0003943_abnormal_hepatobiliary_system0.83341285
125MP0005394_taste/olfaction_phenotype0.83139950
126MP0005499_abnormal_olfactory_system0.83139950
127MP0003115_abnormal_respiratory_system0.82835250
128MP0005275_abnormal_skin_tensile0.82683994
129MP0005248_abnormal_Harderian_gland0.82631308
130MP0002184_abnormal_innervation0.82566969
131MP0005171_absent_coat_pigmentation0.82562478
132MP0003123_paternal_imprinting0.82393448
133MP0002882_abnormal_neuron_morphology0.81058945
134MP0005391_vision/eye_phenotype0.80836389
135MP0003718_maternal_effect0.80718858
136MP0000313_abnormal_cell_death0.80233802
137MP0005257_abnormal_intraocular_pressure0.78315124
138MP0000534_abnormal_ureter_morphology0.76746120
139MP0001984_abnormal_olfaction0.75697329
140MP0000049_abnormal_middle_ear0.73447644
141MP0003566_abnormal_cell_adhesion0.72538525
142MP0002210_abnormal_sex_determination0.72231647
143MP0001177_atelectasis0.71558084
144MP0002116_abnormal_craniofacial_bone0.70233783
145MP0002269_muscular_atrophy0.68870891
146MP0002114_abnormal_axial_skeleton0.68470218

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.66655811
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.66655811
3Insidious onset (HP:0003587)4.46246403
4Termporal pattern (HP:0011008)4.46246403
5Abnormality of the corticospinal tract (HP:0002492)3.83191038
6Pseudobulbar signs (HP:0002200)3.66884122
7Sensory axonal neuropathy (HP:0003390)3.55209733
8Esophageal atresia (HP:0002032)3.37544012
9Nephroblastoma (Wilms tumor) (HP:0002667)3.17631104
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07077251
11Increased nuchal translucency (HP:0010880)3.03987403
12Embryonal renal neoplasm (HP:0011794)3.00941412
13Chromsome breakage (HP:0040012)2.99474206
14Hyporeflexia of lower limbs (HP:0002600)2.96324662
15Chin dimple (HP:0010751)2.88998904
16Cerebral inclusion bodies (HP:0100314)2.83964915
17Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.62747765
18Hepatoblastoma (HP:0002884)2.55323199
19Abnormal lung lobation (HP:0002101)2.54932073
20Multiple enchondromatosis (HP:0005701)2.50184586
21Meckel diverticulum (HP:0002245)2.49096250
22Ependymoma (HP:0002888)2.46000808
23Abnormality of the labia minora (HP:0012880)2.42820993
24Abnormality of the ileum (HP:0001549)2.41252599
25Peripheral hypomyelination (HP:0007182)2.38472616
26Ulnar claw (HP:0001178)2.35471304
27Abnormal auditory evoked potentials (HP:0006958)2.34761365
28Hypoplastic pelvis (HP:0008839)2.30875193
29Abnormality of the astrocytes (HP:0100707)2.28233587
30Astrocytoma (HP:0009592)2.28233587
31High anterior hairline (HP:0009890)2.26386071
32Abnormality of glycolysis (HP:0004366)2.25773543
33Large earlobe (HP:0009748)2.24723770
34Biliary tract neoplasm (HP:0100574)2.24576131
35Birth length less than 3rd percentile (HP:0003561)2.21665313
36Abnormality of chromosome stability (HP:0003220)2.20758825
37Facial hemangioma (HP:0000329)2.20361167
38Rhabdomyosarcoma (HP:0002859)2.19548578
39Pancreatic islet-cell hyperplasia (HP:0004510)2.16526672
40Colon cancer (HP:0003003)2.16293408
41Abnormality of the preputium (HP:0100587)2.15061068
42Parakeratosis (HP:0001036)2.12259524
43Drooling (HP:0002307)2.11096684
44Excessive salivation (HP:0003781)2.11096684
45Spastic diplegia (HP:0001264)2.11011310
46Hammertoe (HP:0001765)2.09156394
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.07747928
48Coronal craniosynostosis (HP:0004440)2.07364829
49Embryonal neoplasm (HP:0002898)2.07205021
50Round ear (HP:0100830)2.05747504
51Spastic gait (HP:0002064)2.04793144
52Neurofibrillary tangles (HP:0002185)2.03512625
53Papillary thyroid carcinoma (HP:0002895)2.02541118
54Volvulus (HP:0002580)2.02508387
55Urinary urgency (HP:0000012)2.02035049
56Decreased motor nerve conduction velocity (HP:0003431)1.99809510
57Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.99689641
58Progressive external ophthalmoplegia (HP:0000590)1.98818191
59Morphological abnormality of the pyramidal tract (HP:0002062)1.97974065
60Neoplasm of the adrenal cortex (HP:0100641)1.97754240
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.96214519
62Medulloblastoma (HP:0002885)1.94798204
63Overlapping toe (HP:0001845)1.94425546
64Heterotopia (HP:0002282)1.93571886
65Stenosis of the external auditory canal (HP:0000402)1.92712218
66Buphthalmos (HP:0000557)1.91145296
67Difficulty running (HP:0009046)1.89532114
68Increased serum pyruvate (HP:0003542)1.89049699
69Intention tremor (HP:0002080)1.88708832
70Abnormality of the foot musculature (HP:0001436)1.88348254
71Autoamputation (HP:0001218)1.87656755
72Abnormal hemoglobin (HP:0011902)1.87179813
73Onion bulb formation (HP:0003383)1.86997711
74Sparse lateral eyebrow (HP:0005338)1.86806701
75Foot dorsiflexor weakness (HP:0009027)1.86800431
76Rib fusion (HP:0000902)1.86780552
77Glioma (HP:0009733)1.85019881
78Rimmed vacuoles (HP:0003805)1.84631279
79Gastrointestinal atresia (HP:0002589)1.83878057
80Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83401685
81Bowel incontinence (HP:0002607)1.81956929
82Abnormality of the salivary glands (HP:0010286)1.81786960
83Abnormality of abdominal situs (HP:0011620)1.81272869
84Abdominal situs inversus (HP:0003363)1.81272869
85Supernumerary ribs (HP:0005815)1.81155741
86Duodenal stenosis (HP:0100867)1.80436467
87Small intestinal stenosis (HP:0012848)1.80436467
88Short humerus (HP:0005792)1.80395406
89Pterygium (HP:0001059)1.80190147
90Myelomeningocele (HP:0002475)1.79751497
91Proximal placement of thumb (HP:0009623)1.79552330
92Oligodactyly (hands) (HP:0001180)1.79363159
93Absent eyebrow (HP:0002223)1.79361685
94Aplasia/hypoplasia of the humerus (HP:0006507)1.79162071
95Absent radius (HP:0003974)1.79132588
96Asymmetry of the thorax (HP:0001555)1.78896671
97Exercise-induced muscle cramps (HP:0003710)1.78710237
98Vertebral clefting (HP:0008428)1.78518938
99Absent forearm bone (HP:0003953)1.77471294
100Aplasia involving forearm bones (HP:0009822)1.77471294
101Neoplasm of the oral cavity (HP:0100649)1.77241116
102Abnormality of the parathyroid morphology (HP:0011766)1.77228639
103Bifid tongue (HP:0010297)1.76975947
104Abnormality of the septum pellucidum (HP:0007375)1.76594643
105Facial cleft (HP:0002006)1.76519018
106Neoplasm of the adrenal gland (HP:0100631)1.76280464
107Scapular winging (HP:0003691)1.74912569
108Relative macrocephaly (HP:0004482)1.73327377
109Abnormality of the antihelix (HP:0009738)1.73319844
110Alacrima (HP:0000522)1.73303970
111Abnormality of methionine metabolism (HP:0010901)1.73098777
112Ectopic kidney (HP:0000086)1.73082610
113Absent septum pellucidum (HP:0001331)1.72164442
114Steppage gait (HP:0003376)1.71869515
115Absent epiphyses (HP:0010577)1.71019715
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71019715
117Broad alveolar ridges (HP:0000187)1.70391512
118Action tremor (HP:0002345)1.70264544
119Skull defect (HP:0001362)1.69744371
120Partial agenesis of the corpus callosum (HP:0001338)1.69068460
121Abnormality of the tricuspid valve (HP:0001702)1.68848382
122Hypopigmentation of the fundus (HP:0007894)1.68015033
123Abnormal large intestine physiology (HP:0012700)1.66793358
124Neoplasm of the colon (HP:0100273)1.66386511
125Transitional cell carcinoma of the bladder (HP:0006740)1.65974790
126Choanal atresia (HP:0000453)1.65157973
127Ankyloglossia (HP:0010296)1.64776889
128Uterine neoplasm (HP:0010784)1.64486722
129Anal stenosis (HP:0002025)1.64040316
130Horseshoe kidney (HP:0000085)1.63981803
131Abnormality of the carotid arteries (HP:0005344)1.63959735
132Deviation of the thumb (HP:0009603)1.63446255
133Urinary bladder sphincter dysfunction (HP:0002839)1.62714812
134Urethral obstruction (HP:0000796)1.62641735
135Abnormality of the shoulder girdle musculature (HP:0001435)1.61872389
136Supernumerary bones of the axial skeleton (HP:0009144)1.61812946
137Malignant gastrointestinal tract tumors (HP:0006749)1.61536899
138Gastrointestinal carcinoma (HP:0002672)1.61536899
139Scanning speech (HP:0002168)1.61415615
140Abnormality of the duodenum (HP:0002246)1.61395549
141Myelodysplasia (HP:0002863)1.61235400
142Abnormality of the 4th metacarpal (HP:0010012)1.61197642
143Obsessive-compulsive behavior (HP:0000722)1.61098511
144Cafe-au-lait spot (HP:0000957)1.60566412
145Missing ribs (HP:0000921)1.60559106
146Cortical dysplasia (HP:0002539)1.60487714
147Muscle fiber splitting (HP:0003555)1.60380328
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.60299575
149Hamartoma (HP:0010566)1.58448898
150Uterine leiomyosarcoma (HP:0002891)1.58446716
151Leiomyosarcoma (HP:0100243)1.58446716
152Glossoptosis (HP:0000162)1.58237837
153Anophthalmia (HP:0000528)1.58222968
154Abnormality of the musculature of the pelvis (HP:0001469)1.57985281
155Abnormality of the hip-girdle musculature (HP:0001445)1.57985281
156Selective tooth agenesis (HP:0001592)1.57429950
157Shoulder girdle muscle weakness (HP:0003547)1.57176334
158Cupped ear (HP:0000378)1.55892089
159Scrotal hypoplasia (HP:0000046)1.55569101
160Abnormality of chromosome segregation (HP:0002916)1.55512063
161Anteriorly placed anus (HP:0001545)1.55179078
162Atresia of the external auditory canal (HP:0000413)1.54731754
163Aqueductal stenosis (HP:0002410)1.54707632
164Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.53726071
165Supernumerary spleens (HP:0009799)1.53679728
166Deep philtrum (HP:0002002)1.53454363
167Cystic hygroma (HP:0000476)1.51920919
168Microglossia (HP:0000171)1.51572088
169Sandal gap (HP:0001852)1.51020037
170Septo-optic dysplasia (HP:0100842)1.50510156
171Infantile muscular hypotonia (HP:0008947)1.50256886
172Insomnia (HP:0100785)1.49724572
173Abnormality of endocrine pancreas physiology (HP:0012093)1.49010497
174Abnormality of the pancreatic islet cells (HP:0006476)1.49010497
175Irregular epiphyses (HP:0010582)1.47731597
176Postnatal microcephaly (HP:0005484)1.47621288
177Right ventricular cardiomyopathy (HP:0011663)1.47263150
178Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.46964980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.19814297
2STK393.82455195
3BUB12.84046518
4NEK12.55009106
5TAF12.39461845
6EIF2AK12.38320845
7TNIK2.24203315
8EIF2AK32.23305217
9TRIM282.21921886
10FGFR22.15113599
11LATS12.11143462
12MET1.97393675
13TLK11.94605726
14WNK11.85906348
15SRPK11.79321238
16BCR1.78330225
17PLK41.72067440
18MAP3K101.63056029
19UHMK11.59184335
20WNK41.57909162
21OXSR11.55986059
22EEF2K1.55117821
23CSNK1A1L1.54247667
24CSNK1G31.52149356
25MKNK11.50564852
26BRSK21.49962435
27MARK11.49491378
28STK38L1.48314388
29CDK121.47916917
30CDC71.47380776
31NEK21.45666424
32PKN11.42726930
33TTN1.40697015
34RPS6KB21.40442449
35MST41.37939640
36EPHB11.37551752
37ICK1.37021561
38TYRO31.36810214
39CSNK1G11.34949245
40NTRK11.32632245
41PLK11.32527980
42KSR21.31176959
43ERBB31.28521246
44ALK1.27915692
45CSNK1G21.24685474
46EPHA21.24544725
47MELK1.24015572
48VRK21.23859970
49EPHB21.20033622
50SMG11.19809085
51CASK1.19417129
52PAK61.18104376
53PAK31.17475851
54ROCK21.12518372
55CSNK1D1.11563522
56MAP3K91.10662974
57BRSK11.10596288
58KSR11.10439188
59TTK1.09185465
60STK111.06956182
61CDK61.06654833
62CHEK21.05563937
63ZAK1.05178704
64CSNK1E1.03518524
65ERBB41.02079828
66MKNK21.01174690
67ATR1.00888277
68PASK1.00222659
69LATS20.99925060
70CDK70.94506994
71CAMK1G0.94295706
72MAP3K40.93244910
73MST1R0.90789429
74DYRK20.88736571
75MAP3K20.88375102
76DMPK0.87722649
77LIMK10.87327396
78STK30.83642789
79BMPR1B0.83057226
80TSSK60.82074320
81RPS6KA40.82047500
82PAK20.81822506
83EPHA40.81686393
84PLK30.79135950
85GSK3A0.76786098
86EIF2AK20.76408629
87PAK40.74297452
88FER0.73577299
89STK240.72893810
90PDGFRA0.72033589
91SIK30.70470689
92VRK10.69494249
93SCYL20.69405268
94MTOR0.68917221
95PLK20.67442810
96DYRK30.67033329
97CDK80.66957582
98RET0.66770738
99PDGFRB0.66443423
100TESK20.65242190
101CAMK2B0.65018979
102STK160.64904449
103BRD40.64735153
104RPS6KA50.64506132
105FGFR10.63326418
106MAP3K80.62774891
107PRKD10.62341047
108YES10.62131740
109TGFBR10.61502350
110NUAK10.60624513
111STK100.60057457
112PHKG20.58872166
113PHKG10.58872166
114WNK30.58188861
115NME10.58082102
116CLK10.57925611
117CDK90.57110316
118PBK0.55938065
119PRKD20.55543811
120PKN20.55382687
121MAPK100.54637137
122INSR0.54565703
123NLK0.53592157
124DDR20.53412067
125MARK20.52308360
126WEE10.51515775
127STK40.50981184
128PRKDC0.50146488
129LRRK20.50125649
130AKT30.49572491
131NTRK30.49273387
132ATM0.48470365
133* CDK10.48435870
134NTRK20.47742123
135CDK20.44552033
136ROCK10.44283533
137* CHEK10.43157470
138PTK20.43149741
139FLT30.42202624
140FRK0.41198802
141CDK40.40636272
142DYRK1B0.40349880
143AURKB0.39963058
144ADRBK10.39714172
145PRKCI0.39232668
146BRAF0.39046996
147CAMK2A0.38817348
148RPS6KB10.38075853

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.82790049
2DNA replication_Homo sapiens_hsa030303.21451505
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.15244589
4Systemic lupus erythematosus_Homo sapiens_hsa053222.86651492
5Mismatch repair_Homo sapiens_hsa034302.84796822
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84057010
7Steroid biosynthesis_Homo sapiens_hsa001002.75853902
8* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64365054
9Nitrogen metabolism_Homo sapiens_hsa009102.10236559
10Axon guidance_Homo sapiens_hsa043602.06820949
11Fatty acid elongation_Homo sapiens_hsa000622.06490025
12Ether lipid metabolism_Homo sapiens_hsa005651.97262957
13Basal cell carcinoma_Homo sapiens_hsa052171.93186841
14Nucleotide excision repair_Homo sapiens_hsa034201.92643928
15Vitamin B6 metabolism_Homo sapiens_hsa007501.92521584
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89375697
17Alcoholism_Homo sapiens_hsa050341.88194993
18* Tight junction_Homo sapiens_hsa045301.88137037
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85052035
20Proteasome_Homo sapiens_hsa030501.84158312
21Basal transcription factors_Homo sapiens_hsa030221.82073664
22Renal cell carcinoma_Homo sapiens_hsa052111.73790935
23Base excision repair_Homo sapiens_hsa034101.72007738
24Hippo signaling pathway_Homo sapiens_hsa043901.68291262
25Protein export_Homo sapiens_hsa030601.65784919
26Biosynthesis of amino acids_Homo sapiens_hsa012301.63743318
27Hedgehog signaling pathway_Homo sapiens_hsa043401.59606774
28RNA degradation_Homo sapiens_hsa030181.58200847
29Homologous recombination_Homo sapiens_hsa034401.55004032
30RNA polymerase_Homo sapiens_hsa030201.52987211
31Butanoate metabolism_Homo sapiens_hsa006501.52115601
32Dorso-ventral axis formation_Homo sapiens_hsa043201.49402810
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.48880176
34MicroRNAs in cancer_Homo sapiens_hsa052061.45770050
35Fanconi anemia pathway_Homo sapiens_hsa034601.45164366
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45004331
37Ribosome_Homo sapiens_hsa030101.40195757
38Pyruvate metabolism_Homo sapiens_hsa006201.36352328
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35995012
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35465651
41Long-term depression_Homo sapiens_hsa047301.32762016
42Carbon metabolism_Homo sapiens_hsa012001.32258740
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29786144
44Selenocompound metabolism_Homo sapiens_hsa004501.24935867
45mRNA surveillance pathway_Homo sapiens_hsa030151.24570665
46Melanogenesis_Homo sapiens_hsa049161.17492637
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16334437
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13818849
49* Wnt signaling pathway_Homo sapiens_hsa043101.12214853
50Oocyte meiosis_Homo sapiens_hsa041141.07355740
51* Adherens junction_Homo sapiens_hsa045201.06628579
52TGF-beta signaling pathway_Homo sapiens_hsa043501.05589367
53Spliceosome_Homo sapiens_hsa030401.02676499
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02037490
55Colorectal cancer_Homo sapiens_hsa052101.01940653
56Prostate cancer_Homo sapiens_hsa052151.00946637
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99809994
58Lysine degradation_Homo sapiens_hsa003100.96300732
59Pyrimidine metabolism_Homo sapiens_hsa002400.96103454
60Viral carcinogenesis_Homo sapiens_hsa052030.93778664
61p53 signaling pathway_Homo sapiens_hsa041150.93249575
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90849659
63ErbB signaling pathway_Homo sapiens_hsa040120.90580531
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89692284
65Estrogen signaling pathway_Homo sapiens_hsa049150.89511073
66Choline metabolism in cancer_Homo sapiens_hsa052310.89188615
67RNA transport_Homo sapiens_hsa030130.88168822
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85327968
69AMPK signaling pathway_Homo sapiens_hsa041520.83787701
70Proteoglycans in cancer_Homo sapiens_hsa052050.83424286
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82843841
72Focal adhesion_Homo sapiens_hsa045100.82298800
73ECM-receptor interaction_Homo sapiens_hsa045120.82175444
74One carbon pool by folate_Homo sapiens_hsa006700.82113324
75Gap junction_Homo sapiens_hsa045400.81849695
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80443293
77Dopaminergic synapse_Homo sapiens_hsa047280.80328890
78Long-term potentiation_Homo sapiens_hsa047200.80270632
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.79943785
80Purine metabolism_Homo sapiens_hsa002300.79807162
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78228766
82Endometrial cancer_Homo sapiens_hsa052130.74060125
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73770755
84Fatty acid biosynthesis_Homo sapiens_hsa000610.73441706
85N-Glycan biosynthesis_Homo sapiens_hsa005100.72983631
86Serotonergic synapse_Homo sapiens_hsa047260.72945542
87Pentose phosphate pathway_Homo sapiens_hsa000300.72741628
88Sulfur metabolism_Homo sapiens_hsa009200.72704525
89Ras signaling pathway_Homo sapiens_hsa040140.72378731
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71742462
91GnRH signaling pathway_Homo sapiens_hsa049120.71615970
92Glioma_Homo sapiens_hsa052140.70863369
93Tyrosine metabolism_Homo sapiens_hsa003500.69468581
94Propanoate metabolism_Homo sapiens_hsa006400.69461529
95Glutamatergic synapse_Homo sapiens_hsa047240.69228761
96Pathways in cancer_Homo sapiens_hsa052000.69127145
97Renin secretion_Homo sapiens_hsa049240.68826930
98Melanoma_Homo sapiens_hsa052180.68370091
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65972445
100Cardiac muscle contraction_Homo sapiens_hsa042600.64944673
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.63050267
102mTOR signaling pathway_Homo sapiens_hsa041500.62965339
103Fatty acid metabolism_Homo sapiens_hsa012120.60743960
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59084788
105Fat digestion and absorption_Homo sapiens_hsa049750.58877010
106Phototransduction_Homo sapiens_hsa047440.58748988
107Linoleic acid metabolism_Homo sapiens_hsa005910.58173374
108Dilated cardiomyopathy_Homo sapiens_hsa054140.57992729
109Thyroid cancer_Homo sapiens_hsa052160.57489954
110Cell cycle_Homo sapiens_hsa041100.57384231
111Small cell lung cancer_Homo sapiens_hsa052220.57332492
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56669238
113Arginine and proline metabolism_Homo sapiens_hsa003300.56619785
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56559915
115Rap1 signaling pathway_Homo sapiens_hsa040150.55091818
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.54557063
117Viral myocarditis_Homo sapiens_hsa054160.53938808
118Oxytocin signaling pathway_Homo sapiens_hsa049210.52779570
119Chronic myeloid leukemia_Homo sapiens_hsa052200.52455439
120VEGF signaling pathway_Homo sapiens_hsa043700.52174726
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52089096
122Alzheimers disease_Homo sapiens_hsa050100.51692817
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51292054
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50822317
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.48238326
126Histidine metabolism_Homo sapiens_hsa003400.48190880
127Bladder cancer_Homo sapiens_hsa052190.48021420
128Prion diseases_Homo sapiens_hsa050200.46700585
129Cholinergic synapse_Homo sapiens_hsa047250.46030675
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45552313
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44565816
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44290741
133Non-homologous end-joining_Homo sapiens_hsa034500.44273292
134FoxO signaling pathway_Homo sapiens_hsa040680.44107040
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43524894
136Inositol phosphate metabolism_Homo sapiens_hsa005620.42940864
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.41316447
138Arginine biosynthesis_Homo sapiens_hsa002200.40157171
139Fructose and mannose metabolism_Homo sapiens_hsa000510.39868668
140Glutathione metabolism_Homo sapiens_hsa004800.37763985
141Glucagon signaling pathway_Homo sapiens_hsa049220.37371032
142Pancreatic cancer_Homo sapiens_hsa052120.34750085
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33742305
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33272997
145Circadian rhythm_Homo sapiens_hsa047100.31243323
146Insulin signaling pathway_Homo sapiens_hsa049100.30505685
147Metabolic pathways_Homo sapiens_hsa011000.26023078

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