CSNK2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26241914
2ribosomal small subunit biogenesis (GO:0042274)4.99721481
3sperm-egg recognition (GO:0035036)4.73348211
4ATP synthesis coupled proton transport (GO:0015986)4.72040297
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.72040297
6binding of sperm to zona pellucida (GO:0007339)4.70326711
7DNA deamination (GO:0045006)4.68942159
8fusion of sperm to egg plasma membrane (GO:0007342)4.67254932
9viral transcription (GO:0019083)4.62445330
10translational termination (GO:0006415)4.39993313
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28830912
12ribosomal large subunit biogenesis (GO:0042273)4.23855450
13cell-cell recognition (GO:0009988)4.20103470
14protein targeting to ER (GO:0045047)4.18920282
15cotranslational protein targeting to membrane (GO:0006613)4.18706885
16sperm motility (GO:0030317)4.14705932
17formation of translation preinitiation complex (GO:0001731)4.12064981
18establishment of integrated proviral latency (GO:0075713)4.04965611
19translational elongation (GO:0006414)4.03491811
20protein localization to endoplasmic reticulum (GO:0070972)4.03380318
21chaperone-mediated protein transport (GO:0072321)4.01720779
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.99152584
23regulation of mitochondrial translation (GO:0070129)3.98988773
24cell wall macromolecule metabolic process (GO:0044036)3.92562251
25cell wall macromolecule catabolic process (GO:0016998)3.92562251
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.88766236
27translational initiation (GO:0006413)3.87878520
28maturation of SSU-rRNA (GO:0030490)3.84847261
29DNA strand elongation involved in DNA replication (GO:0006271)3.83567934
30respiratory electron transport chain (GO:0022904)3.82871811
31ribonucleoprotein complex biogenesis (GO:0022613)3.77056764
32translation (GO:0006412)3.77009207
33oxidative phosphorylation (GO:0006119)3.76350460
34protein maturation by protein folding (GO:0022417)3.75354418
35electron transport chain (GO:0022900)3.71658186
36viral life cycle (GO:0019058)3.70185013
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64851969
38synaptonemal complex assembly (GO:0007130)3.64404265
39protein targeting to mitochondrion (GO:0006626)3.64180525
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63601131
41DNA strand elongation (GO:0022616)3.63401656
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.61446395
43multicellular organism reproduction (GO:0032504)3.60882377
44establishment of viral latency (GO:0019043)3.60528361
45sequestering of actin monomers (GO:0042989)3.60215365
46telomere maintenance via semi-conservative replication (GO:0032201)3.57673963
47acrosome assembly (GO:0001675)3.56089975
48protein localization to chromosome, centromeric region (GO:0071459)3.52256798
49synaptonemal complex organization (GO:0070193)3.52061492
50DNA replication checkpoint (GO:0000076)3.51824414
51cellular protein complex disassembly (GO:0043624)3.49811161
52piRNA metabolic process (GO:0034587)3.49682775
53nucleobase biosynthetic process (GO:0046112)3.48441925
54purine nucleobase biosynthetic process (GO:0009113)3.46045572
55DNA replication initiation (GO:0006270)3.44931778
56DNA replication-dependent nucleosome assembly (GO:0006335)3.44430953
57DNA replication-dependent nucleosome organization (GO:0034723)3.44430953
58cellular component biogenesis (GO:0044085)3.41430264
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39015648
60male meiosis (GO:0007140)3.38536043
61mitotic metaphase plate congression (GO:0007080)3.37681232
62spermatid development (GO:0007286)3.37200158
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37193553
64mitotic nuclear envelope disassembly (GO:0007077)3.36414284
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36164015
66telomere maintenance via recombination (GO:0000722)3.34676103
67establishment of protein localization to mitochondrion (GO:0072655)3.32363216
68chromosome condensation (GO:0030261)3.27898206
69plasma membrane fusion (GO:0045026)3.27359231
70nucleobase-containing small molecule interconversion (GO:0015949)3.25710110
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25428291
72transcription-coupled nucleotide-excision repair (GO:0006283)3.21392675
73folic acid-containing compound biosynthetic process (GO:0009396)3.19179535
74motile cilium assembly (GO:0044458)3.18902968
75protein localization to mitochondrion (GO:0070585)3.18462705
76termination of RNA polymerase III transcription (GO:0006386)3.17702256
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.17702256
78negative regulation of ligase activity (GO:0051352)3.15512139
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15512139
80protein complex biogenesis (GO:0070271)3.15270094
81protein complex disassembly (GO:0043241)3.13980404
82acrosome reaction (GO:0007340)3.12546464
83rRNA processing (GO:0006364)3.11774030
84ribosome biogenesis (GO:0042254)3.10752602
85mitochondrial respiratory chain complex assembly (GO:0033108)3.10148813
86pseudouridine synthesis (GO:0001522)3.09894672
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09131140
88nuclear envelope disassembly (GO:0051081)3.08371050
89membrane disassembly (GO:0030397)3.08371050
90protein localization to kinetochore (GO:0034501)3.08027684
912-deoxyribonucleotide biosynthetic process (GO:0009265)3.07008920
92deoxyribose phosphate biosynthetic process (GO:0046385)3.07008920
93DNA packaging (GO:0006323)3.06795520
94GDP-mannose metabolic process (GO:0019673)3.06011595
95histone exchange (GO:0043486)3.05375864
96reproduction (GO:0000003)3.05144084
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04323454
98viral mRNA export from host cell nucleus (GO:0046784)3.03269262
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03075777
100macromolecular complex disassembly (GO:0032984)3.02766399
101ATP biosynthetic process (GO:0006754)3.02039161
102regulation of translational fidelity (GO:0006450)3.01666470
103proteasome assembly (GO:0043248)3.01082410
104pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99938747
105DNA unwinding involved in DNA replication (GO:0006268)2.99252987
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98602291
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98602291
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.98212248
109NADH dehydrogenase complex assembly (GO:0010257)2.98212248
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98212248
111mitotic recombination (GO:0006312)2.98131792
112tRNA aminoacylation for protein translation (GO:0006418)2.98130018
113chromatin remodeling at centromere (GO:0031055)2.97063416
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96042295
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96042295
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96042295
117purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96016268
118protein deneddylation (GO:0000338)2.94870382
119rRNA metabolic process (GO:0016072)2.94348524
120positive regulation of cell cycle arrest (GO:0071158)2.94164702
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94021215
122regulation of cellular amino acid metabolic process (GO:0006521)2.91113596
123chaperone-mediated protein complex assembly (GO:0051131)2.90825030
124cullin deneddylation (GO:0010388)2.90076510
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.89955103
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89955103
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.87983897
128positive regulation of ligase activity (GO:0051351)2.87504301
129CENP-A containing nucleosome assembly (GO:0034080)2.85051694
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.84813371
131spliceosomal snRNP assembly (GO:0000387)2.82915261
132cilium or flagellum-dependent cell motility (GO:0001539)2.82318084
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81144318
134postreplication repair (GO:0006301)2.80453894
135mitotic sister chromatid segregation (GO:0000070)2.79245660
136rRNA modification (GO:0000154)2.78684678
137microtubule depolymerization (GO:0007019)2.77859683
138axonemal dynein complex assembly (GO:0070286)2.77651843
139telomere maintenance via telomere lengthening (GO:0010833)2.77451502
140regulation of cilium movement (GO:0003352)2.76859925
141regulation of ligase activity (GO:0051340)2.75474714
142cell cycle G1/S phase transition (GO:0044843)2.73949018
143G1/S transition of mitotic cell cycle (GO:0000082)2.73949018
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72715204
145establishment of chromosome localization (GO:0051303)2.72713639
146ribosome assembly (GO:0042255)2.71862987
147meiotic nuclear division (GO:0007126)2.71544684
148metaphase plate congression (GO:0051310)2.71188428
149antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70655581
150DNA replication-independent nucleosome assembly (GO:0006336)2.70073842
151DNA replication-independent nucleosome organization (GO:0034724)2.70073842
152attachment of spindle microtubules to kinetochore (GO:0008608)2.69857353
153folic acid metabolic process (GO:0046655)2.69650328
154ribosomal small subunit assembly (GO:0000028)2.69077052
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.68087854
156regulation of spindle checkpoint (GO:0090231)2.66516063
157chromosome organization involved in meiosis (GO:0070192)2.65974092
158meiosis I (GO:0007127)2.65918957
159mitotic chromosome condensation (GO:0007076)2.63853492
160regulation of chromosome segregation (GO:0051983)2.63248546
161protein complex localization (GO:0031503)2.63158370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.69715030
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.26388064
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71595702
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38002456
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.94443266
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83048920
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65235716
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61907093
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.59578880
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.59566137
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58020447
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.57202198
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53158682
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52680323
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41865404
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30417799
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29608536
18XRN2_22483619_ChIP-Seq_HELA_Human2.06877236
19VDR_23849224_ChIP-Seq_CD4+_Human1.95058358
20* GABP_19822575_ChIP-Seq_HepG2_Human1.91476749
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85975316
22DCP1A_22483619_ChIP-Seq_HELA_Human1.77014666
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75971075
24AR_21909140_ChIP-Seq_LNCAP_Human1.74275943
25* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72994546
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71780470
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71379938
28FOXP3_21729870_ChIP-Seq_TREG_Human1.68682848
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67814721
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66155857
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65338191
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.60653645
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60424097
34MYC_22102868_ChIP-Seq_BL_Human1.57592503
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55158179
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52643869
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49632518
38ZNF263_19887448_ChIP-Seq_K562_Human1.49595926
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49083914
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48453306
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45535748
42* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44967159
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42875842
44* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42122597
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41711520
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41208047
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40712731
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.39667057
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39665529
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38693300
51KDM5A_27292631_Chip-Seq_BREAST_Human1.38419053
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37911006
53TTF2_22483619_ChIP-Seq_HELA_Human1.35852951
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33270147
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33209573
56* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33184966
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30870049
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28706262
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.28164745
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20088269
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19792037
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19727071
63CIITA_25753668_ChIP-Seq_RAJI_Human1.19716818
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19703608
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17399138
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15696168
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11314061
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10751804
69* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07324514
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06526748
71VDR_21846776_ChIP-Seq_THP-1_Human1.06139091
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04720124
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04497873
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02819812
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02124495
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01516954
77TFEB_21752829_ChIP-Seq_HELA_Human1.01228938
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01074691
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00816626
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00237708
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99996102
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99433263
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99229587
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99192144
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98427747
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98095808
87ELK1_19687146_ChIP-ChIP_HELA_Human0.98010464
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97666607
89* SPI1_23547873_ChIP-Seq_NB4_Human0.97459252
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96674687
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.96334252
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96042776
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.95349079
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94744269
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93549661
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.93267068
97* YY1_22570637_ChIP-Seq_MALME-3M_Human0.93182348
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92863417
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92624912
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.92398505
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92054293
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91525589
103BCL6_27268052_Chip-Seq_Bcells_Human0.90409075
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90322632
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.89442808
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89333068
107* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88697652
108* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87955451
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87591145
110NCOR1_26117541_ChIP-Seq_K562_Human0.87226412
111BCOR_27268052_Chip-Seq_Bcells_Human0.87205039
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85947948
113IRF8_21731497_ChIP-ChIP_J774_Mouse0.85803049
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85583503
115PHF8_20622854_ChIP-Seq_HELA_Human0.84832281
116MAF_26560356_Chip-Seq_TH2_Human0.84172249
117* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83545119
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83275708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.06268910
2MP0003693_abnormal_embryo_hatching4.69926987
3MP0003111_abnormal_nucleus_morphology3.39683207
4MP0010094_abnormal_chromosome_stability3.37058349
5* MP0004957_abnormal_blastocyst_morpholog3.32195199
6MP0003077_abnormal_cell_cycle3.28120021
7MP0008877_abnormal_DNA_methylation2.73483553
8MP0008058_abnormal_DNA_repair2.58191405
9MP0008007_abnormal_cellular_replicative2.47273037
10MP0001929_abnormal_gametogenesis2.42536085
11MP0002653_abnormal_ependyma_morphology2.29215905
12MP0003806_abnormal_nucleotide_metabolis2.11208284
13MP0005058_abnormal_lysosome_morphology2.07671959
14MP0003646_muscle_fatigue2.05872688
15MP0008057_abnormal_DNA_replication2.04397713
16MP0003698_abnormal_male_reproductive2.03280026
17MP0009697_abnormal_copulation2.02867721
18MP0008932_abnormal_embryonic_tissue2.02432224
19* MP0001730_embryonic_growth_arrest1.92359841
20MP0009333_abnormal_splenocyte_physiolog1.89636495
21MP0002210_abnormal_sex_determination1.88235123
22MP0002163_abnormal_gland_morphology1.82206306
23MP0009379_abnormal_foot_pigmentation1.76917087
24MP0003186_abnormal_redox_activity1.76187215
25MP0000372_irregular_coat_pigmentation1.74893623
26MP0004147_increased_porphyrin_level1.71127423
27MP0000350_abnormal_cell_proliferation1.66426141
28MP0001545_abnormal_hematopoietic_system1.64843959
29MP0005397_hematopoietic_system_phenotyp1.64843959
30MP0010307_abnormal_tumor_latency1.62375373
31MP0001145_abnormal_male_reproductive1.61084941
32MP0003786_premature_aging1.58931207
33MP0003123_paternal_imprinting1.52170453
34MP0000678_abnormal_parathyroid_gland1.50956920
35MP0002396_abnormal_hematopoietic_system1.50601334
36MP0005408_hypopigmentation1.49303773
37MP0003718_maternal_effect1.48922492
38MP0003315_abnormal_perineum_morphology1.48580492
39MP0000490_abnormal_crypts_of1.48143010
40MP0010352_gastrointestinal_tract_polyps1.47221470
41MP0002019_abnormal_tumor_incidence1.44759303
42MP0003763_abnormal_thymus_physiology1.44707991
43MP0005083_abnormal_biliary_tract1.44098430
44MP0000653_abnormal_sex_gland1.41219484
45MP0001873_stomach_inflammation1.39025507
46MP0002161_abnormal_fertility/fecundity1.33727077
47MP0000313_abnormal_cell_death1.31688153
48* MP0001697_abnormal_embryo_size1.31604238
49MP0004233_abnormal_muscle_weight1.30351695
50MP0000858_altered_metastatic_potential1.28246387
51MP0006036_abnormal_mitochondrial_physio1.28201393
52MP0005501_abnormal_skin_physiology1.27696768
53* MP0002080_prenatal_lethality1.26326984
54* MP0005380_embryogenesis_phenotype1.26064524
55* MP0001672_abnormal_embryogenesis/_devel1.26064524
56MP0001835_abnormal_antigen_presentation1.25830312
57MP0000358_abnormal_cell_content/1.25755195
58MP0008995_early_reproductive_senescence1.24346868
59MP0010030_abnormal_orbit_morphology1.23432133
60MP0002877_abnormal_melanocyte_morpholog1.23320014
61MP0001529_abnormal_vocalization1.20201156
62* MP0003984_embryonic_growth_retardation1.19630954
63MP0002398_abnormal_bone_marrow1.18658561
64MP0004808_abnormal_hematopoietic_stem1.17664664
65MP0005360_urolithiasis1.15100592
66* MP0002088_abnormal_embryonic_growth/wei1.14916602
67MP0002132_abnormal_respiratory_system1.14098590
68MP0003656_abnormal_erythrocyte_physiolo1.13556648
69MP0001881_abnormal_mammary_gland1.12837044
70MP0003436_decreased_susceptibility_to1.11225340
71MP0002722_abnormal_immune_system1.10152796
72MP0005451_abnormal_body_composition1.10006322
73MP0009785_altered_susceptibility_to1.09815378
74MP0009840_abnormal_foam_cell1.09209234
75MP0003705_abnormal_hypodermis_morpholog1.08731468
76MP0002139_abnormal_hepatobiliary_system1.08403525
77MP0000689_abnormal_spleen_morphology1.08067680
78MP0000685_abnormal_immune_system1.06729722
79MP0002405_respiratory_system_inflammati1.03949201
80MP0001727_abnormal_embryo_implantation1.02162445
81MP0002160_abnormal_reproductive_system1.00437094
82MP0005671_abnormal_response_to1.00302355
83MP0005670_abnormal_white_adipose1.00197741
84MP0006054_spinal_hemorrhage0.99995295
85MP0005332_abnormal_amino_acid0.99628557
86MP0002429_abnormal_blood_cell0.98581115
87MP0000703_abnormal_thymus_morphology0.97028063
88MP0001853_heart_inflammation0.96552268
89MP0005379_endocrine/exocrine_gland_phen0.96196898
90MP0005636_abnormal_mineral_homeostasis0.94460683
91MP0001661_extended_life_span0.92313039
92* MP0002085_abnormal_embryonic_tissue0.91501767
93MP0001119_abnormal_female_reproductive0.90783060
94MP0001764_abnormal_homeostasis0.90331437
95MP0000716_abnormal_immune_system0.89580443
96* MP0002086_abnormal_extraembryonic_tissu0.87894121
97MP0004197_abnormal_fetal_growth/weight/0.87144451
98MP0005025_abnormal_response_to0.84492287
99MP0005023_abnormal_wound_healing0.84148119
100MP0006292_abnormal_olfactory_placode0.83866840
101MP0005084_abnormal_gallbladder_morpholo0.82794404
102MP0009278_abnormal_bone_marrow0.82488544
103MP0000609_abnormal_liver_physiology0.80966100
104MP0003448_altered_tumor_morphology0.80459045
105MP0002084_abnormal_developmental_patter0.80124071
106MP0009672_abnormal_birth_weight0.79889697
107MP0005319_abnormal_enzyme/_coenzyme0.79557493
108MP0002420_abnormal_adaptive_immunity0.79236304
109MP0001819_abnormal_immune_cell0.79164870
110MP0005076_abnormal_cell_differentiation0.78652130
111MP0002938_white_spotting0.78503517
112MP0002452_abnormal_antigen_presenting0.78412425
113MP0001800_abnormal_humoral_immune0.77904329
114MP0000598_abnormal_liver_morphology0.77487895
115MP0002723_abnormal_immune_serum0.77416452
116MP0008789_abnormal_olfactory_epithelium0.76266515
117MP0003221_abnormal_cardiomyocyte_apopto0.75431538
118MP0006035_abnormal_mitochondrial_morpho0.72512867
119MP0000750_abnormal_muscle_regeneration0.72327524
120MP0005330_cardiomyopathy0.70293093
121MP0001845_abnormal_inflammatory_respons0.69999447
122MP0002269_muscular_atrophy0.69946278
123MP0005000_abnormal_immune_tolerance0.69767626
124MP0000343_altered_response_to0.69572645
125MP0002148_abnormal_hypersensitivity_rea0.68954703
126MP0001849_ear_inflammation0.68516427
127MP0008873_increased_physiological_sensi0.67832296
128MP0005389_reproductive_system_phenotype0.67764127
129MP0005384_cellular_phenotype0.66842299
130MP0005464_abnormal_platelet_physiology0.66371338
131MP0003566_abnormal_cell_adhesion0.65530164
132MP0008469_abnormal_protein_level0.64498790
133MP0009053_abnormal_anal_canal0.64465427
134MP0002796_impaired_skin_barrier0.64426788
135MP0005365_abnormal_bile_salt0.63433718
136MP0003699_abnormal_female_reproductive0.62943573
137MP0001346_abnormal_lacrimal_gland0.62200119
138MP0005621_abnormal_cell_physiology0.62180922
139MP0008260_abnormal_autophagy0.61741928
140MP0003191_abnormal_cellular_cholesterol0.60678570
141MP0005584_abnormal_enzyme/coenzyme_acti0.58803068

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.01850147
2Acute necrotizing encephalopathy (HP:0006965)4.78548728
3Abnormal mitochondria in muscle tissue (HP:0008316)4.76804321
4Mitochondrial inheritance (HP:0001427)4.40654970
5Acute encephalopathy (HP:0006846)4.34080524
6Degeneration of anterior horn cells (HP:0002398)4.32862844
7Abnormality of the anterior horn cell (HP:0006802)4.32862844
8Nasal polyposis (HP:0100582)4.26904372
9Hepatocellular necrosis (HP:0001404)4.17036484
10Chronic bronchitis (HP:0004469)4.15127343
11Increased CSF lactate (HP:0002490)4.13262332
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.02840710
13Absent/shortened dynein arms (HP:0200106)4.02840710
14Increased hepatocellular lipid droplets (HP:0006565)3.96013072
15Birth length less than 3rd percentile (HP:0003561)3.92996518
16Progressive macrocephaly (HP:0004481)3.67604257
17Increased intramyocellular lipid droplets (HP:0012240)3.54652516
18Renal Fanconi syndrome (HP:0001994)3.53727796
19Lipid accumulation in hepatocytes (HP:0006561)3.53517630
20Oral leukoplakia (HP:0002745)3.53035382
21Abnormality of the nasal mucosa (HP:0000433)3.52006531
22Macrocytic anemia (HP:0001972)3.36407335
23Cerebral edema (HP:0002181)3.30579454
24Bronchitis (HP:0012387)3.28364212
25Lactic acidosis (HP:0003128)3.24603759
26Multiple enchondromatosis (HP:0005701)3.23668768
27Infertility (HP:0000789)3.19201834
28Microvesicular hepatic steatosis (HP:0001414)3.17821082
29Type I transferrin isoform profile (HP:0003642)3.16970535
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16584589
313-Methylglutaconic aciduria (HP:0003535)3.13855067
32Aplasia/Hypoplasia of the sacrum (HP:0008517)3.10403885
33Carpal bone hypoplasia (HP:0001498)3.09355604
34Abnormal spermatogenesis (HP:0008669)3.09103015
35Breast hypoplasia (HP:0003187)3.08733309
36Male infertility (HP:0003251)3.05373545
37Impulsivity (HP:0100710)3.04052033
38Increased muscle lipid content (HP:0009058)3.03293411
39Exercise intolerance (HP:0003546)3.02050262
40Abnormal number of erythroid precursors (HP:0012131)3.01639136
41Abnormality of cells of the erythroid lineage (HP:0012130)2.97970647
42Respiratory difficulties (HP:0002880)2.85072080
43Selective tooth agenesis (HP:0001592)2.84929852
44Cerebral hypomyelination (HP:0006808)2.84574780
45Rhinitis (HP:0012384)2.84315133
46Abnormal respiratory motile cilium morphology (HP:0005938)2.80220375
47Abnormal respiratory epithelium morphology (HP:0012253)2.80220375
48Respiratory failure (HP:0002878)2.72151304
49Recurrent bronchitis (HP:0002837)2.70522125
50Rough bone trabeculation (HP:0100670)2.70445738
51Abnormal respiratory motile cilium physiology (HP:0012261)2.68969219
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68755607
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68755607
54Exertional dyspnea (HP:0002875)2.56898832
55Patellar aplasia (HP:0006443)2.55617108
56Rhabdomyolysis (HP:0003201)2.55111840
57Aplastic anemia (HP:0001915)2.49095383
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48289784
59Trismus (HP:0000211)2.45359875
60Poor head control (HP:0002421)2.44974454
61Microretrognathia (HP:0000308)2.43903150
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.43155904
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42957260
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41962118
65Aplasia/Hypoplasia of the patella (HP:0006498)2.41615982
66Emotional lability (HP:0000712)2.39244506
67Cholelithiasis (HP:0001081)2.37535986
68Abnormal protein glycosylation (HP:0012346)2.36247714
69Abnormal glycosylation (HP:0012345)2.36247714
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36247714
71Abnormal protein N-linked glycosylation (HP:0012347)2.36247714
72Reduced antithrombin III activity (HP:0001976)2.31629105
73Ragged-red muscle fibers (HP:0003200)2.29305207
74Reticulocytosis (HP:0001923)2.28429632
75Cleft eyelid (HP:0000625)2.27494768
76Hypertensive crisis (HP:0100735)2.27336868
77Personality changes (HP:0000751)2.22588147
78Reticulocytopenia (HP:0001896)2.22284591
79Abnormality of methionine metabolism (HP:0010901)2.20910518
80Secondary amenorrhea (HP:0000869)2.19743480
81Generalized aminoaciduria (HP:0002909)2.16557445
82Abnormal gallbladder morphology (HP:0012437)2.14718971
83Abnormality of pyrimidine metabolism (HP:0004353)2.13530998
84Premature ovarian failure (HP:0008209)2.13262881
85Lethargy (HP:0001254)2.12271981
86Thrombocytosis (HP:0001894)2.09559105
87Tongue fasciculations (HP:0001308)2.09482579
88Testicular atrophy (HP:0000029)2.09034144
89Recurrent otitis media (HP:0000403)2.07607252
90Bronchiectasis (HP:0002110)2.07452657
91Spastic paraparesis (HP:0002313)2.06418854
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04770370
9311 pairs of ribs (HP:0000878)2.03826213
94Nausea (HP:0002018)2.02894587
95Sparse eyelashes (HP:0000653)2.01557834
96Azoospermia (HP:0000027)2.00628185
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00222807
98Dicarboxylic aciduria (HP:0003215)2.00222807
99Agnosia (HP:0010524)1.99430395
100Muscle fibrillation (HP:0010546)1.99426251
101Leukodystrophy (HP:0002415)1.99019195
102Meckel diverticulum (HP:0002245)1.99016593
103Opisthotonus (HP:0002179)1.98714965
104Bone marrow hypocellularity (HP:0005528)1.98122740
105Muscle fiber atrophy (HP:0100295)1.97349279
106Seborrheic dermatitis (HP:0001051)1.97312355
107Pancytopenia (HP:0001876)1.96060787
108Cellular immunodeficiency (HP:0005374)1.93356869
109Abnormality of the preputium (HP:0100587)1.93235841
110CNS demyelination (HP:0007305)1.91392399
111Abnormality of the ileum (HP:0001549)1.90184104
112Upper limb muscle weakness (HP:0003484)1.89622545
113Sloping forehead (HP:0000340)1.88906372
114Truncus arteriosus (HP:0001660)1.88870638
115Hypokinesia (HP:0002375)1.88493923
116Abnormal trabecular bone morphology (HP:0100671)1.87792404
117Optic disc pallor (HP:0000543)1.87733848
118Abnormal hemoglobin (HP:0011902)1.87371299
119Chromsome breakage (HP:0040012)1.85554916
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85368535
121Premature graying of hair (HP:0002216)1.85205966
122Hyperthyroidism (HP:0000836)1.85072600
123Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84484893
124Absent thumb (HP:0009777)1.83614664
125Neoplasm of the pancreas (HP:0002894)1.83415108
126Type 2 muscle fiber atrophy (HP:0003554)1.82970221
127Abnormality of sulfur amino acid metabolism (HP:0004339)1.82819950
128Progressive muscle weakness (HP:0003323)1.82544572
129Abnormal gallbladder physiology (HP:0012438)1.82220496
130Cholecystitis (HP:0001082)1.82220496
131Abnormality of the gallbladder (HP:0005264)1.81351783
132Recurrent sinusitis (HP:0011108)1.81338290
133Absent epiphyses (HP:0010577)1.80372049
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80372049
135Ileus (HP:0002595)1.79614404
136Methylmalonic aciduria (HP:0012120)1.78428198
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.77415198
138Abnormality of chromosome stability (HP:0003220)1.75922807
139Recurrent abscess formation (HP:0002722)1.74949356
140Increased serum lactate (HP:0002151)1.73743241
141Neoplasm of head and neck (HP:0012288)1.73638182
142Esophageal neoplasm (HP:0100751)1.73638182
143Myelodysplasia (HP:0002863)1.73236615
144Abnormality of the motor neurons (HP:0002450)1.71640857
145Abnormal neuron morphology (HP:0012757)1.71640857
146Horseshoe kidney (HP:0000085)1.71535437
147Hepatosplenomegaly (HP:0001433)1.70796298
148Progressive microcephaly (HP:0000253)1.70559640
149Paralysis (HP:0003470)1.70537100
150Abnormality of reticulocytes (HP:0004312)1.70228627
151Pulmonary fibrosis (HP:0002206)1.69093929
152Delayed CNS myelination (HP:0002188)1.68786903
153Gout (HP:0001997)1.66801626
154Tracheoesophageal fistula (HP:0002575)1.66188189
155Slender long bone (HP:0003100)1.64970972
156Small intestinal stenosis (HP:0012848)1.64729975
157Duodenal stenosis (HP:0100867)1.64729975
158Pallor (HP:0000980)1.63661921
159Hepatic necrosis (HP:0002605)1.63283404
160Ulnar deviation of the wrist (HP:0003049)1.62295351
161Irregular epiphyses (HP:0010582)1.61887342
162Myoglobinuria (HP:0002913)1.61817756
163Increased serum pyruvate (HP:0003542)1.61591953
164Abnormality of glycolysis (HP:0004366)1.61591953
165Recurrent bacterial skin infections (HP:0005406)1.57214499
166Abnormality of T cells (HP:0002843)1.55609751
167Petechiae (HP:0000967)1.55497927
168Megaloblastic anemia (HP:0001889)1.54273931
169Death in infancy (HP:0001522)1.54242525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.01825600
2TESK14.16195283
3PDK34.04578143
4PDK44.04578143
5BUB14.00357173
6EIF2AK13.10605549
7WEE12.96081871
8TESK22.82864773
9CDC72.68860595
10NEK22.60066324
11PDK22.48910465
12NME22.45127670
13NEK12.30005600
14NME12.21023107
15PLK41.99191320
16IRAK31.84610718
17MST41.79355120
18RPS6KA41.67705039
19BRSK21.64167168
20TTK1.59539722
21SMG11.57878817
22ARAF1.54138304
23PRKD31.52484867
24ACVR1B1.51821503
25PLK11.48103007
26EIF2AK31.47573223
27ERN11.41686897
28DYRK31.38736985
29MAP4K11.36365827
30MAP3K121.34313809
31CCNB11.33535915
32TRIB31.32508296
33BCKDK1.31999161
34TSSK61.30337189
35PASK1.30094382
36STK38L1.29631747
37BRSK11.24928947
38PIM21.22968680
39ZAP701.21712204
40STK161.19843767
41DAPK11.19374360
42EEF2K1.18529026
43CLK11.18265481
44AURKB1.16660867
45MAP3K81.12221712
46STK101.11373026
47PAK41.11368879
48ATR1.11197418
49CDK71.07927255
50CDK41.07006110
51KDR1.05377807
52ICK1.04593182
53MAP3K111.03446326
54VRK10.98079151
55PKN20.96498850
56CHEK20.93866412
57SRPK10.93734366
58TRIM280.89475671
59PAK10.87573408
60PIM10.86877705
61AURKA0.86535044
62LRRK20.84581589
63CSNK1G30.82133182
64NUAK10.80550391
65ILK0.78051538
66SCYL20.77904541
67BRAF0.76077738
68CDK190.75210103
69TYK20.74252644
70MAPKAPK30.73928935
71LATS20.73169645
72RPS6KB20.72631214
73FLT30.71768219
74TLK10.71142574
75RAF10.70735530
76MAP2K30.70414888
77PLK30.70203174
78DAPK30.70177639
79STK40.70033511
80* CHEK10.69400017
81TAOK10.68352252
82TBK10.68156801
83JAK30.66068853
84MAP3K100.64744043
85LIMK10.61218651
86ABL20.60225758
87STK30.58524635
88EIF2AK20.56087122
89CSNK1A1L0.54070937
90TAF10.53357041
91EPHA20.52446696
92TGFBR10.51161489
93RPS6KA50.48972702
94PBK0.47673258
95CDK120.47422596
96* CSNK2A10.46224110
97BTK0.45732116
98TAOK20.44810102
99BLK0.43993258
100SIK30.43291871
101CDK20.41537037
102GRK60.41457135
103CSNK1G10.41154247
104DYRK1B0.41092384
105ATM0.38932332
106MAP3K30.38924404
107NEK90.38890183
108DYRK20.38550921
109AKT20.36338821
110CDK80.35868893
111ZAK0.35686125
112MAP3K50.35674155
113MAPKAPK50.34715962
114* CSNK2A20.32368748
115CDK90.32089690
116MAP2K60.31688744
117NLK0.31295312
118ALK0.30990018
119MARK30.30840860
120KSR20.29917716
121MAPKAPK20.29424751
122* CDK10.28307332
123TXK0.28010525
124MYLK0.26974034
125CSNK1G20.26421471
126STK380.26377063
127MAP4K20.26307319
128PRKCI0.26043770
129MAPK110.25901041
130IKBKB0.24178156
131CHUK0.23356737
132CDK60.23216593
133IKBKE0.23164566
134* CDK11A0.20466043
135* CDK140.18434914
136BMX0.15848985

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.20036527
2Proteasome_Homo sapiens_hsa030504.00873483
3Mismatch repair_Homo sapiens_hsa034303.05526700
4RNA polymerase_Homo sapiens_hsa030202.81747160
5Base excision repair_Homo sapiens_hsa034102.75689807
6RNA transport_Homo sapiens_hsa030132.71874151
7* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67166071
8Pyrimidine metabolism_Homo sapiens_hsa002402.47571047
9Spliceosome_Homo sapiens_hsa030402.44495069
10Ribosome_Homo sapiens_hsa030102.35530231
11Cell cycle_Homo sapiens_hsa041102.24914428
12Homologous recombination_Homo sapiens_hsa034402.24201143
13Nucleotide excision repair_Homo sapiens_hsa034202.14389979
14Vitamin B6 metabolism_Homo sapiens_hsa007502.03894057
15Pentose phosphate pathway_Homo sapiens_hsa000302.01106342
16One carbon pool by folate_Homo sapiens_hsa006701.95346227
17Basal transcription factors_Homo sapiens_hsa030221.91524751
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.82762930
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69761779
20Alzheimers disease_Homo sapiens_hsa050101.69473041
21Biosynthesis of amino acids_Homo sapiens_hsa012301.69192410
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.68392345
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67365066
24Fatty acid elongation_Homo sapiens_hsa000621.64874070
25Carbon metabolism_Homo sapiens_hsa012001.56815576
26Fanconi anemia pathway_Homo sapiens_hsa034601.52389080
27RNA degradation_Homo sapiens_hsa030181.48557240
28Pyruvate metabolism_Homo sapiens_hsa006201.40965197
29Selenocompound metabolism_Homo sapiens_hsa004501.36036121
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33432522
31Purine metabolism_Homo sapiens_hsa002301.32936231
32mRNA surveillance pathway_Homo sapiens_hsa030151.29848362
33p53 signaling pathway_Homo sapiens_hsa041151.29492663
34Antigen processing and presentation_Homo sapiens_hsa046121.28292565
35Sulfur relay system_Homo sapiens_hsa041221.26605009
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23739210
37Folate biosynthesis_Homo sapiens_hsa007901.19204813
38Fructose and mannose metabolism_Homo sapiens_hsa000511.17053254
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14804596
40* Epstein-Barr virus infection_Homo sapiens_hsa051691.12059058
41Legionellosis_Homo sapiens_hsa051341.11761867
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07754360
43Non-homologous end-joining_Homo sapiens_hsa034501.06834145
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06616312
45Glutathione metabolism_Homo sapiens_hsa004801.05032853
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01490970
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.96096801
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94818301
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91147813
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89354899
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86742015
52Oocyte meiosis_Homo sapiens_hsa041140.84669467
53Steroid biosynthesis_Homo sapiens_hsa001000.84026443
54Huntingtons disease_Homo sapiens_hsa050160.83369839
55Sulfur metabolism_Homo sapiens_hsa009200.82858842
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80226985
57* Herpes simplex infection_Homo sapiens_hsa051680.79815617
58Galactose metabolism_Homo sapiens_hsa000520.74404377
59Vibrio cholerae infection_Homo sapiens_hsa051100.73771359
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.73194896
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72803958
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72592080
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72470927
64Cardiac muscle contraction_Homo sapiens_hsa042600.68110899
65Viral carcinogenesis_Homo sapiens_hsa052030.65932927
66Propanoate metabolism_Homo sapiens_hsa006400.64805744
67Shigellosis_Homo sapiens_hsa051310.61224730
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60110458
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57878860
70Protein export_Homo sapiens_hsa030600.56537485
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55762883
72Primary immunodeficiency_Homo sapiens_hsa053400.55504779
73HTLV-I infection_Homo sapiens_hsa051660.55042810
74Collecting duct acid secretion_Homo sapiens_hsa049660.51839008
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51774292
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51153726
77Parkinsons disease_Homo sapiens_hsa050120.49478978
78Tyrosine metabolism_Homo sapiens_hsa003500.49220945
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48486397
80Linoleic acid metabolism_Homo sapiens_hsa005910.47685829
81Influenza A_Homo sapiens_hsa051640.47344810
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46534502
83* Measles_Homo sapiens_hsa051620.45820995
84Systemic lupus erythematosus_Homo sapiens_hsa053220.43981911
85Apoptosis_Homo sapiens_hsa042100.43165759
86Arginine biosynthesis_Homo sapiens_hsa002200.41233354
87Metabolic pathways_Homo sapiens_hsa011000.39707380
88Fat digestion and absorption_Homo sapiens_hsa049750.38553397
89Fatty acid degradation_Homo sapiens_hsa000710.37963431
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37952350
91Thyroid cancer_Homo sapiens_hsa052160.36568166
92Fatty acid metabolism_Homo sapiens_hsa012120.33169057
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.31264151
94N-Glycan biosynthesis_Homo sapiens_hsa005100.29958426
95HIF-1 signaling pathway_Homo sapiens_hsa040660.29771347
96Leishmaniasis_Homo sapiens_hsa051400.29425843
97Oxidative phosphorylation_Homo sapiens_hsa001900.28467026
98Other glycan degradation_Homo sapiens_hsa005110.27978087
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.27013850
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26695681
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26211719
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.23789674
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23434356
104Graft-versus-host disease_Homo sapiens_hsa053320.22625687
105Arginine and proline metabolism_Homo sapiens_hsa003300.22260673
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21755552
107Hepatitis B_Homo sapiens_hsa051610.21234153
108Acute myeloid leukemia_Homo sapiens_hsa052210.18716229
109Phenylalanine metabolism_Homo sapiens_hsa003600.18236939
110Arachidonic acid metabolism_Homo sapiens_hsa005900.18145792
111Peroxisome_Homo sapiens_hsa041460.18025796
112Glucagon signaling pathway_Homo sapiens_hsa049220.17947051
113Renin-angiotensin system_Homo sapiens_hsa046140.17872801
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17479730
115Allograft rejection_Homo sapiens_hsa053300.16852306
116Lysosome_Homo sapiens_hsa041420.16029915
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16012526
118Small cell lung cancer_Homo sapiens_hsa052220.15327719
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14016831
120Bladder cancer_Homo sapiens_hsa052190.13599139
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07610507
122Rheumatoid arthritis_Homo sapiens_hsa053230.07326279

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