CSPG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.13046299
2protein heterotrimerization (GO:0070208)5.70622387
3chondrocyte proliferation (GO:0035988)5.64015694
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.34979722
5chondrocyte development (GO:0002063)4.52325472
6endodermal cell differentiation (GO:0035987)4.51278827
7vascular endothelial growth factor signaling pathway (GO:0038084)4.51240213
8skin morphogenesis (GO:0043589)4.46184945
9collagen metabolic process (GO:0032963)4.34625287
10plasma membrane repair (GO:0001778)4.34281871
11collagen catabolic process (GO:0030574)4.34131746
12cardiac myofibril assembly (GO:0055003)4.31515070
13multicellular organismal macromolecule metabolic process (GO:0044259)4.13892510
14positive regulation of endothelial cell apoptotic process (GO:2000353)4.13118795
15multicellular organismal catabolic process (GO:0044243)3.98079864
16bone trabecula formation (GO:0060346)3.91839843
17multicellular organismal metabolic process (GO:0044236)3.89091131
18glomerular filtration (GO:0003094)3.81334219
19barbed-end actin filament capping (GO:0051016)3.76266612
20extracellular matrix disassembly (GO:0022617)3.72392785
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.68970459
22cell-substrate adherens junction assembly (GO:0007045)3.68125645
23focal adhesion assembly (GO:0048041)3.68125645
24sequestering of extracellular ligand from receptor (GO:0035581)3.68076999
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.63290288
26basement membrane organization (GO:0071711)3.61363579
27negative regulation of homotypic cell-cell adhesion (GO:0034111)3.59154112
28cell adhesion mediated by integrin (GO:0033627)3.56020445
29glomerular basement membrane development (GO:0032836)3.53241135
30wound healing, spreading of epidermal cells (GO:0035313)3.46781866
31renal filtration (GO:0097205)3.45466602
32keratan sulfate catabolic process (GO:0042340)3.41191277
33cell aggregation (GO:0098743)3.36998897
34cartilage condensation (GO:0001502)3.36998897
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.36615583
36axon extension involved in axon guidance (GO:0048846)3.36615583
37positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.36479323
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.34925281
39regulation of plasminogen activation (GO:0010755)3.28027459
40negative regulation of fatty acid transport (GO:2000192)3.27937569
41myofibril assembly (GO:0030239)3.25453373
42negative regulation of chondrocyte differentiation (GO:0032331)3.22663675
43endothelial cell morphogenesis (GO:0001886)3.21723607
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20547613
45positive regulation of blood vessel endothelial cell migration (GO:0043536)3.19923134
46melanin biosynthetic process (GO:0042438)3.19398289
47metanephric mesenchyme development (GO:0072075)3.17268501
48positive regulation of extracellular matrix organization (GO:1903055)3.16556485
49replacement ossification (GO:0036075)3.15758107
50endochondral ossification (GO:0001958)3.15758107
51semaphorin-plexin signaling pathway (GO:0071526)3.15304786
52apoptotic cell clearance (GO:0043277)3.14947972
53Golgi transport vesicle coating (GO:0048200)3.13486604
54COPI coating of Golgi vesicle (GO:0048205)3.13486604
55muscle cell migration (GO:0014812)3.12605448
56protein retention in ER lumen (GO:0006621)3.11756691
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.09981356
58protein localization to endosome (GO:0036010)3.08424906
59negative regulation of smooth muscle cell migration (GO:0014912)3.07545314
60extracellular matrix organization (GO:0030198)3.07324888
61substrate-dependent cell migration (GO:0006929)3.07238913
62regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.06843128
63adhesion of symbiont to host cell (GO:0044650)3.06770169
64virion attachment to host cell (GO:0019062)3.06770169
65cell-substrate junction assembly (GO:0007044)3.06125983
66extracellular structure organization (GO:0043062)3.05941524
67positive regulation of astrocyte differentiation (GO:0048711)3.05453769
68kidney mesenchyme development (GO:0072074)3.04842758
69* chondroitin sulfate biosynthetic process (GO:0030206)3.02657999
70cell proliferation involved in metanephros development (GO:0072203)3.02465401
71cell migration involved in heart development (GO:0060973)3.02026246
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.01837082
73actin filament depolymerization (GO:0030042)2.98704050
74negative regulation of cartilage development (GO:0061037)2.96527527
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96366395
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94161601
77* dermatan sulfate biosynthetic process (GO:0030208)2.92636626
78adhesion of symbiont to host (GO:0044406)2.92368602
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92026500
80glomerular visceral epithelial cell development (GO:0072015)2.89526938
81extracellular matrix assembly (GO:0085029)2.87451618
82positive regulation of cartilage development (GO:0061036)2.87073499
83stress fiber assembly (GO:0043149)2.87040044
84cell migration involved in sprouting angiogenesis (GO:0002042)2.86047562
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85789680
86regulation of chondrocyte differentiation (GO:0032330)2.84998962
87hypotonic response (GO:0006971)2.84010325
88positive regulation of osteoblast proliferation (GO:0033690)2.83500284
89regulation of cartilage development (GO:0061035)2.81826739
90melanin metabolic process (GO:0006582)2.81289648
91fibril organization (GO:0097435)2.78902619
92negative regulation of adherens junction organization (GO:1903392)2.74537057
93negative regulation of focal adhesion assembly (GO:0051895)2.74537057
94negative regulation of cell junction assembly (GO:1901889)2.74537057
95substrate adhesion-dependent cell spreading (GO:0034446)2.73735654
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.73351690
97peptidyl-proline hydroxylation (GO:0019511)2.73136542
98* dermatan sulfate metabolic process (GO:0030205)2.73011078
99cellular response to vitamin (GO:0071295)2.72312162
100trabecula formation (GO:0060343)2.72046812
101regulation of tight junction assembly (GO:2000810)2.70140887
102cartilage development (GO:0051216)2.69619095
103positive regulation of chondrocyte differentiation (GO:0032332)2.68584608
104positive regulation of axon extension (GO:0045773)2.68183639
105epithelial cell-cell adhesion (GO:0090136)2.67668448
106hemidesmosome assembly (GO:0031581)2.67631919
107extracellular fibril organization (GO:0043206)2.66483944
108type B pancreatic cell proliferation (GO:0044342)2.65540701
109embryonic viscerocranium morphogenesis (GO:0048703)2.65111175
110regulation of early endosome to late endosome transport (GO:2000641)2.64544052
111cell proliferation involved in kidney development (GO:0072111)2.64494590
112positive regulation of epithelial to mesenchymal transition (GO:0010718)2.64267763
113atrioventricular valve morphogenesis (GO:0003181)2.63563468
114protein localization to cell surface (GO:0034394)2.62706320
115wound healing, spreading of cells (GO:0044319)2.61451251
116positive regulation of fibroblast migration (GO:0010763)2.60693565
117metanephric nephron tubule development (GO:0072234)2.59675236
118metanephric tubule development (GO:0072170)2.59675236
119positive regulation of stem cell differentiation (GO:2000738)2.59374101
120response to fluid shear stress (GO:0034405)2.59254318
121cortical actin cytoskeleton organization (GO:0030866)2.58836084
122mesenchymal-epithelial cell signaling (GO:0060638)2.58826547
123craniofacial suture morphogenesis (GO:0097094)2.57564979
124regulation of axon extension involved in axon guidance (GO:0048841)2.57388095
125heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.56494057
126adherens junction assembly (GO:0034333)2.56149224
127cortical cytoskeleton organization (GO:0030865)2.56001647
128paraxial mesoderm development (GO:0048339)2.55642021
129endocardial cushion morphogenesis (GO:0003203)2.53230683
130protein hydroxylation (GO:0018126)2.53227286
131endocardial cushion development (GO:0003197)2.53063266
132regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.52566518
133notochord development (GO:0030903)2.52380723
134tooth mineralization (GO:0034505)2.51215158
135negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.50758150
136cellular response to amino acid stimulus (GO:0071230)2.50682505
137coronary vasculature morphogenesis (GO:0060977)2.50410496
138cell volume homeostasis (GO:0006884)2.49618358
139negative regulation of catenin import into nucleus (GO:0035414)2.47546149
140sarcomere organization (GO:0045214)2.47407718
141heart morphogenesis (GO:0003007)2.47352456
142regulation of integrin-mediated signaling pathway (GO:2001044)2.47154674
143branching involved in salivary gland morphogenesis (GO:0060445)2.46623405
144peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44899380
145endothelial cell chemotaxis (GO:0035767)2.43950921
146cell-matrix adhesion (GO:0007160)2.43687569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.45297426
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.41628728
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.63111826
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.16948044
5CLOCK_20551151_ChIP-Seq_293T_Human2.47018956
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41163986
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.38287930
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33217571
9AR_21572438_ChIP-Seq_LNCaP_Human2.22089638
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22072162
11* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16727253
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.15588757
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15167669
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15167669
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13224338
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09098352
17CJUN_26792858_Chip-Seq_BT549_Human2.07707724
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.06077623
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.05564130
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04708171
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.01535482
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89956177
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89285791
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86517627
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81761030
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78279726
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74393572
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.73499187
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73374642
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72855367
31ZNF263_19887448_ChIP-Seq_K562_Human1.68390999
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.68064886
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66622565
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63974378
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61270584
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60187237
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56737506
38BRD4_25478319_ChIP-Seq_HGPS_Human1.56542475
39* TBX20_22080862_ChIP-Seq_HEART_Mouse1.56449377
40* TBX20_22328084_ChIP-Seq_HEART_Mouse1.56449377
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55348528
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52591524
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49649307
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49227681
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48738471
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47701659
47TP53_16413492_ChIP-PET_HCT116_Human1.47307465
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45956983
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45956983
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45480193
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45256226
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.44548030
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44240134
54KDM2B_26808549_Chip-Seq_DND41_Human1.42600814
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42447896
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41908660
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.40742520
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39849080
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39682722
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.38775112
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37344908
62TP53_18474530_ChIP-ChIP_U2OS_Human1.35351659
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34459152
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33665662
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32897034
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32794510
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32444454
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31070018
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29396232
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29165966
71* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26540444
72* KDM2B_26808549_Chip-Seq_K562_Human1.22602955
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22392342
74DROSHA_22980978_ChIP-Seq_HELA_Human1.22012628
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20731991
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20273537
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.19904824
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.19661262
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18914946
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.18690946
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18497705
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18321882
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18321882
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17631082
85* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17165344
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15905845
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15682606
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15457726
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.15317295
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.15002937
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.12829126
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10460796
93* TP53_22127205_ChIP-Seq_IMR90_Human1.10060471
94SA1_22415368_ChIP-Seq_MEFs_Mouse1.10031443
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09764698
96ATF3_27146783_Chip-Seq_COLON_Human1.09557040
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.09207251
98* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09166271
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08485407
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08138929
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.08108625
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07277387
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06826133
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06700993
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.04874077
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04290477
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.04205903
108TCF7_22412390_ChIP-Seq_EML_Mouse1.03687972
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.03286292
110SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02550080
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01563495
112CTCF_27219007_Chip-Seq_Bcells_Human1.01062156
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00565132
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99891549
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.99495406
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98938484
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98439540
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98138391
119SOX2_20726797_ChIP-Seq_SW620_Human0.97821442
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97557219
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97389645
122RACK7_27058665_Chip-Seq_MCF-7_Human0.96914494
123LXR_22292898_ChIP-Seq_THP-1_Human0.96349156
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96280288
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95856260
126VDR_21846776_ChIP-Seq_THP-1_Human0.95285737
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.95110804
128RXR_22108803_ChIP-Seq_LS180_Human0.94999683
129EZH2_22144423_ChIP-Seq_EOC_Human0.93812951
130GBX2_23144817_ChIP-Seq_PC3_Human0.93549300
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93372479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.50002761
2MP0005503_abnormal_tendon_morphology4.26568251
3MP0005275_abnormal_skin_tensile4.08416497
4MP0003279_aneurysm3.88964320
5MP0004272_abnormal_basement_membrane3.76779890
6MP0003705_abnormal_hypodermis_morpholog3.33154382
7MP0001958_emphysema3.04299692
8MP0005623_abnormal_meninges_morphology2.82029000
9MP0000751_myopathy2.68529749
10MP0004134_abnormal_chest_morphology2.37977722
11MP0009250_abnormal_appendicular_skeleto2.27299133
12MP0009384_cardiac_valve_regurgitation2.18214361
13MP0003941_abnormal_skin_development2.10973326
14MP0002108_abnormal_muscle_morphology2.02812214
15MP0005508_abnormal_skeleton_morphology2.01954138
16MP0003566_abnormal_cell_adhesion1.97222602
17MP0002282_abnormal_trachea_morphology1.94339615
18MP0003283_abnormal_digestive_organ1.93833321
19MP0002877_abnormal_melanocyte_morpholog1.93339816
20MP0004084_abnormal_cardiac_muscle1.87919442
21MP0000013_abnormal_adipose_tissue1.87563010
22MP0002837_dystrophic_cardiac_calcinosis1.83193973
23* MP0003091_abnormal_cell_migration1.76991062
24MP0001299_abnormal_eye_distance/1.75511879
25MP0000163_abnormal_cartilage_morphology1.69045564
26MP0002896_abnormal_bone_mineralization1.67829842
27MP0010030_abnormal_orbit_morphology1.63838054
28MP0005257_abnormal_intraocular_pressure1.62510836
29MP0000750_abnormal_muscle_regeneration1.56410990
30MP0002295_abnormal_pulmonary_circulatio1.55723683
31MP0002060_abnormal_skin_morphology1.53622294
32MP0000749_muscle_degeneration1.53429836
33MP0005409_darkened_coat_color1.51241188
34MP0000767_abnormal_smooth_muscle1.51152982
35MP0002933_joint_inflammation1.47972998
36MP0000733_abnormal_muscle_development1.47304137
37MP0005023_abnormal_wound_healing1.46315802
38MP0003385_abnormal_body_wall1.44809459
39MP0006054_spinal_hemorrhage1.44070481
40MP0005330_cardiomyopathy1.42708879
41MP0005670_abnormal_white_adipose1.42017372
42MP0001542_abnormal_bone_strength1.41013402
43MP0002115_abnormal_skeleton_extremities1.40596177
44MP0010368_abnormal_lymphatic_system1.33418429
45MP0005058_abnormal_lysosome_morphology1.33310188
46MP0004087_abnormal_muscle_fiber1.31832163
47MP0001849_ear_inflammation1.31271632
48MP0002249_abnormal_larynx_morphology1.26814240
49MP0000003_abnormal_adipose_tissue1.25293453
50MP0006138_congestive_heart_failure1.22274550
51MP0008775_abnormal_heart_ventricle1.21667523
52MP0005666_abnormal_adipose_tissue1.21506589
53MP0004858_abnormal_nervous_system1.18406550
54MP0005375_adipose_tissue_phenotype1.18376504
55MP0009780_abnormal_chondrocyte_physiolo1.16265133
56MP0002113_abnormal_skeleton_development1.15602923
57MP0002089_abnormal_postnatal_growth/wei1.15161944
58MP0000428_abnormal_craniofacial_morphol1.14901442
59MP0005390_skeleton_phenotype1.14745197
60MP0000762_abnormal_tongue_morphology1.14683410
61MP0004036_abnormal_muscle_relaxation1.14078257
62MP0005408_hypopigmentation1.13379307
63MP0005171_absent_coat_pigmentation1.12731438
64MP0005620_abnormal_muscle_contractility1.12131605
65MP0000759_abnormal_skeletal_muscle1.11343265
66MP0001243_abnormal_dermal_layer1.08801937
67MP0003045_fibrosis1.07756862
68MP0004381_abnormal_hair_follicle1.07630384
69MP0002972_abnormal_cardiac_muscle1.07599962
70MP0003950_abnormal_plasma_membrane1.06520822
71MP0000049_abnormal_middle_ear1.06498792
72MP0003755_abnormal_palate_morphology1.06355089
73MP0004145_abnormal_muscle_electrophysio1.06043211
74MP0004185_abnormal_adipocyte_glucose1.05383910
75MP0000462_abnormal_digestive_system1.05013033
76MP0000534_abnormal_ureter_morphology1.03765216
77MP0000015_abnormal_ear_pigmentation1.03269611
78MP0002128_abnormal_blood_circulation1.03071356
79MP0004510_myositis1.02289310
80MP0005595_abnormal_vascular_smooth1.01386494
81MP0001879_abnormal_lymphatic_vessel0.98600647
82MP0002932_abnormal_joint_morphology0.97358917
83MP0003942_abnormal_urinary_system0.96608499
84MP0005369_muscle_phenotype0.96068391
85MP0004215_abnormal_myocardial_fiber0.95816606
86MP0002116_abnormal_craniofacial_bone0.94541473
87MP0010352_gastrointestinal_tract_polyps0.93760501
88MP0005164_abnormal_response_to0.93639516
89MP0010630_abnormal_cardiac_muscle0.92370516
90MP0000432_abnormal_head_morphology0.91969087
91MP0002269_muscular_atrophy0.91866384
92MP0009278_abnormal_bone_marrow0.91506669
93MP0002109_abnormal_limb_morphology0.91066106
94MP0002998_abnormal_bone_remodeling0.90064314
95MP0003935_abnormal_craniofacial_develop0.88765700
96MP0009840_abnormal_foam_cell0.88560750
97MP0003136_yellow_coat_color0.86979001
98MP0009053_abnormal_anal_canal0.85133833
99MP0001614_abnormal_blood_vessel0.84541652
100MP0005385_cardiovascular_system_phenoty0.84499256
101MP0001544_abnormal_cardiovascular_syste0.84499256
102MP0001915_intracranial_hemorrhage0.84475985
103MP0004130_abnormal_muscle_cell0.83456627
104MP0002233_abnormal_nose_morphology0.82881572
105MP0002168_other_aberrant_phenotype0.82452138
106MP0003646_muscle_fatigue0.82097154
107MP0003115_abnormal_respiratory_system0.81665289
108MP0005197_abnormal_uvea_morphology0.80246133
109MP0004233_abnormal_muscle_weight0.79104214
110MP0001348_abnormal_lacrimal_gland0.78932681
111MP0001270_distended_abdomen0.75651374
112MP0002106_abnormal_muscle_physiology0.75461505
113MP0002925_abnormal_cardiovascular_devel0.75086156
114MP0003795_abnormal_bone_structure0.74499471
115MP0000747_muscle_weakness0.74472270
116MP0001661_extended_life_span0.69317901
117MP0003453_abnormal_keratinocyte_physiol0.66675289
118MP0005165_increased_susceptibility_to0.66364937
119MP0003828_pulmonary_edema0.64584722
120MP0002075_abnormal_coat/hair_pigmentati0.63795683
121MP0005451_abnormal_body_composition0.61004442
122MP0003634_abnormal_glial_cell0.60432475
123MP0002114_abnormal_axial_skeleton0.56315872

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.40759211
2Protrusio acetabuli (HP:0003179)6.40609019
3Epiphyseal dysplasia (HP:0002656)4.56172580
4Ankle contracture (HP:0006466)4.43356494
5Neonatal short-limb short stature (HP:0008921)4.27373822
6Aortic dissection (HP:0002647)4.06186847
7Hypoplastic ischia (HP:0003175)4.04464564
8Type 1 muscle fiber predominance (HP:0003803)3.79513795
9Broad metatarsal (HP:0001783)3.71268930
10Shallow orbits (HP:0000586)3.64609150
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.58705899
12Atrophic scars (HP:0001075)3.57423625
13Abnormality of the ischium (HP:0003174)3.51346897
14Cervical subluxation (HP:0003308)3.50389414
15Increased connective tissue (HP:0009025)3.41659985
16Spinal rigidity (HP:0003306)3.32247345
17Cerebral aneurysm (HP:0004944)3.29020026
18Aortic aneurysm (HP:0004942)3.19548860
19Follicular hyperkeratosis (HP:0007502)3.18831023
20Genu recurvatum (HP:0002816)3.16301632
21Peritonitis (HP:0002586)3.09039984
22Abnormality of dentin (HP:0010299)3.08107553
23Soft skin (HP:0000977)3.05979273
24Round ear (HP:0100830)3.01687282
25Bladder diverticulum (HP:0000015)2.99510358
26Increased variability in muscle fiber diameter (HP:0003557)2.92840371
27Cupped ribs (HP:0000887)2.92492905
28Mild short stature (HP:0003502)2.91823823
29Vascular tortuosity (HP:0004948)2.90276904
30Fragile skin (HP:0001030)2.87693667
31Vitreoretinal degeneration (HP:0000655)2.85603253
32Osteoarthritis (HP:0002758)2.84093753
33Mesomelia (HP:0003027)2.83657990
34Dilatation of the ascending aorta (HP:0005111)2.81946810
35Muscle fiber splitting (HP:0003555)2.80656841
36Wormian bones (HP:0002645)2.78007871
37Mildly elevated creatine phosphokinase (HP:0008180)2.73543848
38Achilles tendon contracture (HP:0001771)2.73071335
39Flat acetabular roof (HP:0003180)2.72856187
40Irregular epiphyses (HP:0010582)2.72706412
41Hip contracture (HP:0003273)2.72442187
42Arterial tortuosity (HP:0005116)2.72012086
43Mitral valve prolapse (HP:0001634)2.68134809
44Blue sclerae (HP:0000592)2.62799377
45Hypoventilation (HP:0002791)2.59198799
46Distal lower limb amyotrophy (HP:0008944)2.57168350
47Biconcave vertebral bodies (HP:0004586)2.55514130
48Wrist flexion contracture (HP:0001239)2.54887519
49Slender build (HP:0001533)2.51733493
50Abnormality of skeletal muscle fiber size (HP:0012084)2.50274635
51Flat capital femoral epiphysis (HP:0003370)2.47391589
52Limited hip movement (HP:0008800)2.46531917
53Distal lower limb muscle weakness (HP:0009053)2.44506264
54Platyspondyly (HP:0000926)2.42784341
55Abnormality of the acetabulum (HP:0003170)2.40831281
56Abnormal vertebral ossification (HP:0100569)2.39773542
57Distal arthrogryposis (HP:0005684)2.39617410
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.39306818
59Osteolytic defects of the hand bones (HP:0009699)2.39306818
60Spondylolisthesis (HP:0003302)2.38728314
61Coxa vara (HP:0002812)2.37246800
62Abnormality of the Achilles tendon (HP:0005109)2.35971025
63Radial bowing (HP:0002986)2.35369784
64Small epiphyses (HP:0010585)2.34764968
65Ectopia lentis (HP:0001083)2.33986393
66Generalized amyotrophy (HP:0003700)2.32101863
67Mitral regurgitation (HP:0001653)2.31448056
68Overgrowth (HP:0001548)2.30796269
69Stridor (HP:0010307)2.25194117
70Disproportionate tall stature (HP:0001519)2.24567875
71Elbow flexion contracture (HP:0002987)2.23960802
72Broad ribs (HP:0000885)2.21240067
73Hyperacusis (HP:0010780)2.20232213
74Ulnar deviation of the wrist (HP:0003049)2.17870527
75Long toe (HP:0010511)2.17563893
76Ulnar bowing (HP:0003031)2.17307064
77Abnormal ossification of hand bones (HP:0005921)2.17170041
78Lumbar hyperlordosis (HP:0002938)2.17132999
79Infantile muscular hypotonia (HP:0008947)2.16503223
80Mitral stenosis (HP:0001718)2.16085748
81Broad long bones (HP:0005622)2.15900527
82Hyperextensible skin (HP:0000974)2.13870403
83Breech presentation (HP:0001623)2.13505089
84Vertebral compression fractures (HP:0002953)2.12064206
85Joint laxity (HP:0001388)2.11653887
86Tibial bowing (HP:0002982)2.11635040
87Scapular winging (HP:0003691)2.11607945
88Aortic regurgitation (HP:0001659)2.11126605
89Hand muscle atrophy (HP:0009130)2.10715647
90Obstructive sleep apnea (HP:0002870)2.10541981
91White forelock (HP:0002211)2.07015210
92Hypoplasia of the iris (HP:0007676)2.06230548
93Abnormality of carpal bone ossification (HP:0006257)2.05987322
94Spinal cord compression (HP:0002176)2.05726222
95Bowel diverticulosis (HP:0005222)2.03508878
96Delayed epiphyseal ossification (HP:0002663)2.01602428
97Exostoses (HP:0100777)2.01077308
98Upper limb amyotrophy (HP:0009129)2.00635188
99Distal upper limb amyotrophy (HP:0007149)2.00635188
100Wide anterior fontanel (HP:0000260)2.00222826
101Lower limb amyotrophy (HP:0007210)1.99488736
102Metaphyseal cupping (HP:0003021)1.99398694
103Short hallux (HP:0010109)1.97629481
104Short 4th metacarpal (HP:0010044)1.97403946
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97403946
106Abnormality of the calf musculature (HP:0001430)1.97274891
107Abnormality of the pubic bones (HP:0003172)1.97003332
108Bell-shaped thorax (HP:0001591)1.96732970
109Limb-girdle muscle weakness (HP:0003325)1.95711080
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93134159
111Difficulty climbing stairs (HP:0003551)1.91664725
112Natal tooth (HP:0000695)1.88797518
113Camptodactyly of toe (HP:0001836)1.88356763
114Bowing of the arm (HP:0006488)1.88273584
115Bowed forearm bones (HP:0003956)1.88273584
116Short nail (HP:0001799)1.88152031
117Aneurysm (HP:0002617)1.87984565
118Abnormality of the proximal phalanges of the hand (HP:0009834)1.86983624
119Trismus (HP:0000211)1.86890729
120Calcaneovalgus deformity (HP:0001848)1.85549426
121Broad phalanx (HP:0006009)1.84851174
122Knee flexion contracture (HP:0006380)1.84573701
123Joint stiffness (HP:0001387)1.84429338
124Venous abnormality (HP:0002624)1.83545700
125Abnormal delivery (HP:0001787)1.83099984
126Limited elbow extension (HP:0001377)1.81896708
127Abnormal hand bone ossification (HP:0010660)1.80723326
128Abnormality of the odontoid process (HP:0003310)1.79703951
129Hypoplasia of the odontoid process (HP:0003311)1.79627951
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.79542507
131Thin ribs (HP:0000883)1.78740192
132Ovoid vertebral bodies (HP:0003300)1.78605373
133Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78353197
134Abnormality of femoral epiphyses (HP:0006499)1.78353197
135Renal duplication (HP:0000075)1.78098199
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.78091831
137Abnormal foot bone ossification (HP:0010675)1.77878854
138Hallux valgus (HP:0001822)1.77547503
139Broad face (HP:0000283)1.77486826
140Abnormality of the distal phalanges of the toes (HP:0010182)1.76510583
141Deformed tarsal bones (HP:0008119)1.76066586
142Deviation of the hallux (HP:0010051)1.75567806
143Limb-girdle muscle atrophy (HP:0003797)1.75018383
144Muscle fiber inclusion bodies (HP:0100299)1.73505786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.83160082
2TTN4.92876310
3PDGFRA4.25541492
4TRIB34.17785105
5MYLK2.78217854
6SIK12.71472819
7PKN22.46689600
8DMPK2.37776604
9PAK22.25876563
10LATS22.09438548
11LATS12.08059306
12RIPK11.89422717
13EPHB21.88333346
14CAMK1D1.81982942
15ERBB41.69888014
16PDGFRB1.57121596
17CAMK1G1.56391113
18TRPM71.53774795
19ROCK11.51173368
20BMX1.41796714
21CDK121.37038526
22ERN11.36180912
23PAK31.34468000
24ILK1.33028012
25NEK91.31291832
26PIK3CA1.29693929
27SMG11.26434878
28PTK21.22602025
29PTK61.21976757
30PRKD31.21854706
31PTK2B1.21573614
32AKT31.18769855
33PHKG11.18261962
34PHKG21.18261962
35FER1.17421329
36MAP3K31.16289292
37PRPF4B1.13130169
38EPHA21.10978076
39STK38L1.07715179
40CDC42BPA1.06835964
41PRKG21.06204469
42CASK1.03787556
43STK241.03449033
44TIE11.03077878
45EEF2K1.01527189
46MAPKAPK31.00987021
47FLT30.99610050
48LMTK20.94538784
49ARAF0.94389660
50PAK60.93185746
51MTOR0.91805391
52MAP3K60.90711708
53KIT0.89874440
54NTRK10.87388579
55OBSCN0.85117074
56PRKD10.84693107
57MAP3K130.83744610
58ICK0.83265294
59TAOK10.82926049
60KSR20.82720626
61FGFR10.81696056
62MET0.80731770
63TAOK20.80598325
64ROCK20.80046124
65MOS0.78639297
66MAP2K30.77909808
67TGFBR20.77439079
68PRKCH0.75803512
69PDPK10.74236914
70IRAK30.73359823
71FGFR40.71411119
72RET0.70616460
73PIK3CG0.69994158
74LRRK20.66863723
75MAP2K10.65257200
76PRKD20.64973644
77STK30.62649133
78PDK20.60765770
79DAPK30.60740215
80MAP3K10.56748600
81MST1R0.55445507
82INSR0.54784761
83PIM20.53261736
84FGFR20.53159392
85GSK3A0.52119146
86PINK10.51484584
87CAMKK10.50996421
88MAPK110.50419872
89ADRBK10.50010388
90LIMK10.48683026
91RPS6KA40.48200040
92PRKAA20.48111317
93CAMK2G0.47095958
94AKT20.45902777
95ZAK0.45467922
96TESK10.45444738
97PDK30.45285078
98PDK40.45285078
99ABL20.44501322
100PAK40.43702052
101EPHB10.43055441
102MAP3K70.42698781
103EPHA30.42295547
104NTRK30.41722548
105SRC0.41597401
106SCYL20.40506931
107MAP3K100.40315739
108RPS6KC10.40098241
109RPS6KL10.40098241
110ZAP700.39833220
111WNK10.39151490
112MAPK120.38243866
113MARK10.38073148
114MAPKAPK50.36628448
115MAP3K110.36596530
116NEK20.36384971
117PAK10.36218055
118RPS6KA20.35193047
119CDK70.34609394
120MARK30.34501449
121MAPK40.34045506
122NME20.33328736
123PRKCE0.33254017
124TYRO30.33088679
125ERBB30.32974585
126IGF1R0.32806367
127CDK150.32506272
128MARK20.32457652
129PLK20.32211166
130CAMK10.32071342
131STK380.31757968
132JAK10.29743742
133DYRK1B0.28969949
134MAPK70.28439638
135NUAK10.27504585
136CAMK2D0.25848460

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.13310112
2Focal adhesion_Homo sapiens_hsa045103.40404282
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.39958077
4Protein digestion and absorption_Homo sapiens_hsa049743.15552275
5Dilated cardiomyopathy_Homo sapiens_hsa054143.00176126
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.89306344
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.73178052
8Proteoglycans in cancer_Homo sapiens_hsa052051.98149799
9Amoebiasis_Homo sapiens_hsa051461.88954508
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.85126304
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.77928717
12PI3K-Akt signaling pathway_Homo sapiens_hsa041511.63328740
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62921645
14Adherens junction_Homo sapiens_hsa045201.53837213
15MicroRNAs in cancer_Homo sapiens_hsa052061.51138501
16Other glycan degradation_Homo sapiens_hsa005111.49308356
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45704813
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44448243
19Small cell lung cancer_Homo sapiens_hsa052221.44308303
20Malaria_Homo sapiens_hsa051441.37785386
21Hippo signaling pathway_Homo sapiens_hsa043901.35179322
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35031386
23Basal cell carcinoma_Homo sapiens_hsa052171.33010030
24Prion diseases_Homo sapiens_hsa050201.31940874
25Glioma_Homo sapiens_hsa052141.30873331
26TGF-beta signaling pathway_Homo sapiens_hsa043501.30073317
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29800216
28Bladder cancer_Homo sapiens_hsa052191.29105998
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28133090
30Hedgehog signaling pathway_Homo sapiens_hsa043401.24996612
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.20092197
32Gap junction_Homo sapiens_hsa045401.19952689
33Melanoma_Homo sapiens_hsa052181.16648442
34Viral myocarditis_Homo sapiens_hsa054161.13483199
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12110672
36Tight junction_Homo sapiens_hsa045301.09979758
37Axon guidance_Homo sapiens_hsa043601.07859668
38Cardiac muscle contraction_Homo sapiens_hsa042601.06365801
39Platelet activation_Homo sapiens_hsa046111.05250419
40Renin secretion_Homo sapiens_hsa049241.04842962
41Rap1 signaling pathway_Homo sapiens_hsa040150.98357733
42Oxytocin signaling pathway_Homo sapiens_hsa049210.98247710
43Thyroid cancer_Homo sapiens_hsa052160.97224143
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.96606017
45Chronic myeloid leukemia_Homo sapiens_hsa052200.92795128
46Endometrial cancer_Homo sapiens_hsa052130.90659645
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.90477663
48Estrogen signaling pathway_Homo sapiens_hsa049150.87454722
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87201505
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83492880
51Prostate cancer_Homo sapiens_hsa052150.82712704
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81787743
53AMPK signaling pathway_Homo sapiens_hsa041520.80064530
54Fatty acid biosynthesis_Homo sapiens_hsa000610.80054526
55GnRH signaling pathway_Homo sapiens_hsa049120.79936311
56Insulin resistance_Homo sapiens_hsa049310.79567584
57Non-small cell lung cancer_Homo sapiens_hsa052230.78853308
58Pathways in cancer_Homo sapiens_hsa052000.77923740
59Melanogenesis_Homo sapiens_hsa049160.77593283
60Vibrio cholerae infection_Homo sapiens_hsa051100.77475139
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76839326
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76406222
63Fatty acid metabolism_Homo sapiens_hsa012120.76362907
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76178844
65PPAR signaling pathway_Homo sapiens_hsa033200.75330684
66HIF-1 signaling pathway_Homo sapiens_hsa040660.74444615
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.72745088
68Gastric acid secretion_Homo sapiens_hsa049710.72076202
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.71714692
70Dorso-ventral axis formation_Homo sapiens_hsa043200.70040840
71Lysosome_Homo sapiens_hsa041420.69787084
72cAMP signaling pathway_Homo sapiens_hsa040240.68044255
73Renal cell carcinoma_Homo sapiens_hsa052110.67986791
74Acute myeloid leukemia_Homo sapiens_hsa052210.67985385
75Insulin signaling pathway_Homo sapiens_hsa049100.67899472
76Notch signaling pathway_Homo sapiens_hsa043300.67573443
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67216366
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66439900
79Ovarian steroidogenesis_Homo sapiens_hsa049130.66279597
80Glucagon signaling pathway_Homo sapiens_hsa049220.65870183
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65833015
82Sulfur relay system_Homo sapiens_hsa041220.64498458
83Salivary secretion_Homo sapiens_hsa049700.63406700
84Wnt signaling pathway_Homo sapiens_hsa043100.63401665
85Endocytosis_Homo sapiens_hsa041440.63356260
86MAPK signaling pathway_Homo sapiens_hsa040100.62212262
87Lysine degradation_Homo sapiens_hsa003100.61747100
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60233807
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58662754
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56433603
91Thyroid hormone synthesis_Homo sapiens_hsa049180.56093728
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55732974
93Ras signaling pathway_Homo sapiens_hsa040140.55031932
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54394099
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.54274026
96Calcium signaling pathway_Homo sapiens_hsa040200.52627656
97Toxoplasmosis_Homo sapiens_hsa051450.51207776
98HTLV-I infection_Homo sapiens_hsa051660.50887131
99ErbB signaling pathway_Homo sapiens_hsa040120.50649871
100N-Glycan biosynthesis_Homo sapiens_hsa005100.49668201
101Circadian entrainment_Homo sapiens_hsa047130.48864496
102Cocaine addiction_Homo sapiens_hsa050300.46862202
103Inositol phosphate metabolism_Homo sapiens_hsa005620.46761209
104Galactose metabolism_Homo sapiens_hsa000520.46525630
105Pancreatic cancer_Homo sapiens_hsa052120.46017323
106Long-term potentiation_Homo sapiens_hsa047200.45967426
107VEGF signaling pathway_Homo sapiens_hsa043700.45074259
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44688309
109Cholinergic synapse_Homo sapiens_hsa047250.44527104
110Long-term depression_Homo sapiens_hsa047300.43451672
111Tyrosine metabolism_Homo sapiens_hsa003500.43271985
112mTOR signaling pathway_Homo sapiens_hsa041500.42275057
113Fatty acid degradation_Homo sapiens_hsa000710.42034453
114Propanoate metabolism_Homo sapiens_hsa006400.39703927
115Choline metabolism in cancer_Homo sapiens_hsa052310.39610518
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39543199
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39439132
118Salmonella infection_Homo sapiens_hsa051320.39275198
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38213715
120Phagosome_Homo sapiens_hsa041450.37653697

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