ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	5.94896909
2	motile cilium assembly (GO:0044458)	5.78079208
3	axonemal dynein complex assembly (GO:0070286)	5.00003436
4	cilium movement (GO:0003341)	3.83838832
5	positive regulation of protein kinase C signaling (GO:0090037)	3.69788013
6	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.66183235
7	mRNA cleavage (GO:0006379)	3.64238012
8	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.62401128
9	epithelial cilium movement (GO:0003351)	3.49553475
10	semaphorin-plexin signaling pathway (GO:0071526)	3.48705229
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41802997
12	ventricular system development (GO:0021591)	3.41769268
13	urinary tract smooth muscle contraction (GO:0014848)	3.38360790
14	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.34081059
15	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.33141014
16	paraxial mesoderm development (GO:0048339)	3.29961512
17	lung epithelium development (GO:0060428)	3.29250951
18	cranial nerve morphogenesis (GO:0021602)	3.24746555
19	histone H3-K36 demethylation (GO:0070544)	3.15332973
20	cell migration in hindbrain (GO:0021535)	3.07539427
21	positive regulation of catecholamine secretion (GO:0033605)	3.06457583
22	microtubule severing (GO:0051013)	2.95064726
23	coenzyme catabolic process (GO:0009109)	2.84267886
24	cell-cell junction maintenance (GO:0045217)	2.80975324
25	cell-substrate adherens junction assembly (GO:0007045)	2.80093389
26	focal adhesion assembly (GO:0048041)	2.80093389
27	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.75752110
28	establishment of apical/basal cell polarity (GO:0035089)	2.74774134
29	peptidyl-lysine dimethylation (GO:0018027)	2.74735359
30	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.72672116
31	regulation of NFAT protein import into nucleus (GO:0051532)	2.70820474
32	nucleosome disassembly (GO:0006337)	2.69918326
33	protein-DNA complex disassembly (GO:0032986)	2.69918326
34	adherens junction assembly (GO:0034333)	2.68409398
35	fibroblast migration (GO:0010761)	2.67307363
36	regulation of ARF GTPase activity (GO:0032312)	2.67268978
37	negative regulation of cell size (GO:0045792)	2.63477503
38	stress granule assembly (GO:0034063)	2.61846907
39	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.60469543
40	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.60107538
41	axon extension involved in axon guidance (GO:0048846)	2.60107538
42	protein retention in ER lumen (GO:0006621)	2.59763133
43	neurotransmitter-gated ion channel clustering (GO:0072578)	2.59654774
44	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.59367991
45	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.55577978
46	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.55577978
47	regulation of skeletal muscle contraction (GO:0014819)	2.53091203
48	GDP-mannose metabolic process (GO:0019673)	2.49450494
49	embryonic camera-type eye development (GO:0031076)	2.49007480
50	microtubule depolymerization (GO:0007019)	2.46138637
51	androgen biosynthetic process (GO:0006702)	2.45950249
52	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.45422163
53	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.43903151
54	regulation of translation, ncRNA-mediated (GO:0045974)	2.43903151
55	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.43903151
56	positive regulation of dendrite morphogenesis (GO:0050775)	2.43546868
57	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.42076510
58	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.41821634
59	lateral sprouting from an epithelium (GO:0060601)	2.39903149
60	endothelial cell chemotaxis (GO:0035767)	2.37720034
61	sperm motility (GO:0030317)	2.37611920
62	snRNA metabolic process (GO:0016073)	2.36703782
63	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.36086913
64	establishment of monopolar cell polarity (GO:0061162)	2.36086913
65	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.34416505
66	heterochromatin organization (GO:0070828)	2.34256083
67	regulation of hippo signaling (GO:0035330)	2.33646749
68	activation of protein kinase B activity (GO:0032148)	2.31456727
69	left/right pattern formation (GO:0060972)	2.30741630
70	convergent extension (GO:0060026)	2.30687892
71	mitochondrion distribution (GO:0048311)	2.30663613
72	regulation of fatty acid beta-oxidation (GO:0031998)	2.30636604
73	regulation of establishment of planar polarity (GO:0090175)	2.30559989
74	snRNA processing (GO:0016180)	2.30513330
75	sensory perception of taste (GO:0050909)	2.30057974
76	mannose metabolic process (GO:0006013)	2.29606408
77	sex determination (GO:0007530)	2.29453907
78	regulation of protein kinase C signaling (GO:0090036)	2.26687353
79	positive regulation of smoothened signaling pathway (GO:0045880)	2.26675952
80	negative regulation of cell aging (GO:0090344)	2.26251747
81	ectoderm development (GO:0007398)	2.23564680
82	cytoplasmic mRNA processing body assembly (GO:0033962)	2.23227183
83	histone lysine demethylation (GO:0070076)	2.23114632
84	muscle fiber development (GO:0048747)	2.22897721
85	regulation of posttranscriptional gene silencing (GO:0060147)	2.20511425
86	regulation of gene silencing by miRNA (GO:0060964)	2.20511425
87	regulation of gene silencing by RNA (GO:0060966)	2.20511425
88	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.20047044
89	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.19994439
90	peptidyl-glutamic acid carboxylation (GO:0017187)	2.18593996
91	protein carboxylation (GO:0018214)	2.18593996
92	postsynaptic membrane organization (GO:0001941)	2.18553923
93	cell-substrate junction assembly (GO:0007044)	2.18296977
94	cell junction maintenance (GO:0034331)	2.17447222
95	cochlea morphogenesis (GO:0090103)	2.17381466
96	camera-type eye morphogenesis (GO:0048593)	2.16950292
97	establishment of planar polarity (GO:0001736)	2.16218712
98	establishment of tissue polarity (GO:0007164)	2.16218712
99	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.16130593
100	desmosome organization (GO:0002934)	2.15093476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.11530234
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.75592642
3	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.30693682
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.28809667
5	LXR_22292898_ChIP-Seq_THP-1_Human	2.63024109
6	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.39896705
7	RACK7_27058665_Chip-Seq_MCF-7_Human	2.33380470
8	CTCF_27219007_Chip-Seq_Bcells_Human	2.28096613
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.26162328
10	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.24692290
11	VDR_21846776_ChIP-Seq_THP-1_Human	2.24101286
12	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.22946956
13	P68_20966046_ChIP-Seq_HELA_Human	2.22508285
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.20875725
15	SMC4_20622854_ChIP-Seq_HELA_Human	2.19014564
16	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.10888945
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.06915050
18	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.01483926
19	CREB1_26743006_Chip-Seq_LNCaP_Human	1.98479329
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.95199612
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.95172988
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.91344348
23	KDM2B_26808549_Chip-Seq_DND41_Human	1.89525070
24	KDM2B_26808549_Chip-Seq_K562_Human	1.89044573
25	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.88947010
26	DROSHA_22980978_ChIP-Seq_HELA_Human	1.87175033
27	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.86779901
28	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.85804468
29	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.85574257
30	TP53_22127205_ChIP-Seq_IMR90_Human	1.80065909
31	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.69425543
32	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.64973296
33	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.60024250
34	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.54164323
35	ZNF263_19887448_ChIP-Seq_K562_Human	1.53917757
36	PHF8_20622854_ChIP-Seq_HELA_Human	1.53158015
37	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.51045034
38	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.49316349
39	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.47763327
40	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.47703251
41	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.46433509
42	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.44361570
43	TP63_22573176_ChIP-Seq_HFKS_Human	1.41867983
44	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.40458715
45	E2F1_20622854_ChIP-Seq_HELA_Human	1.39423015
46	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.39206103
47	EZH2_22144423_ChIP-Seq_EOC_Human	1.35957186
48	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.35378753
49	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.35070870
50	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.34963025
51	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.33937756
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33758088
53	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.28329265
54	CTCF_21964334_Chip-Seq_Bcells_Human	1.25465253
55	MAF_26560356_Chip-Seq_TH2_Human	1.25412523
56	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.24518429
57	CHD1_26751641_Chip-Seq_LNCaP_Human	1.24239950
58	BCOR_27268052_Chip-Seq_Bcells_Human	1.23062662
59	CTCF_20526341_ChIP-Seq_ESCs_Human	1.22852188
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22522877
61	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20674545
62	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.20535447
63	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.20068572
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19425944
65	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.17805633
66	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.16757556
67	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.15942584
68	TCF7_22412390_ChIP-Seq_EML_Mouse	1.15511143
69	MYC_22102868_ChIP-Seq_BL_Human	1.15201747
70	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14257423
71	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.13817662
72	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.13221568
73	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.12312923
74	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.11843316
75	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.11501422
76	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.11484134
77	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.10148627
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09310043
79	ERA_21632823_ChIP-Seq_H3396_Human	1.09260678
80	ATF3_27146783_Chip-Seq_COLON_Human	1.08965417
81	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08360002
82	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06868755
83	XRN2_22483619_ChIP-Seq_HELA_Human	1.06184849
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05301474
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04538248
86	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.04345341
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04170567
88	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.02729823
89	OCT4_19829295_ChIP-Seq_ESCs_Human	1.00699092
90	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99333853
91	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99333853
92	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.97988767
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97836828
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.97524035
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.95705917
96	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95415924
97	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.94680438
98	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.94117067
99	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.93717322
100	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.93557366

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.97426894
2	MP0005171_absent_coat_pigmentation	2.57828842
3	MP0000537_abnormal_urethra_morphology	2.53628890
4	MP0005409_darkened_coat_color	2.43791230
5	MP0001188_hyperpigmentation	2.41875448
6	MP0000566_synostosis	2.31133974
7	MP0003705_abnormal_hypodermis_morpholog	2.28474425
8	MP0003315_abnormal_perineum_morphology	2.26301038
9	MP0000751_myopathy	2.19650584
10	MP0002249_abnormal_larynx_morphology	2.19407048
11	MP0010030_abnormal_orbit_morphology	2.14466249
12	MP0005076_abnormal_cell_differentiation	1.98223281
13	MP0010234_abnormal_vibrissa_follicle	1.93267300
14	MP0004272_abnormal_basement_membrane	1.90234953
15	MP0002160_abnormal_reproductive_system	1.87379040
16	MP0001984_abnormal_olfaction	1.70041918
17	MP0001849_ear_inflammation	1.63765695
18	MP0000538_abnormal_urinary_bladder	1.59468228
19	MP0001661_extended_life_span	1.57325719
20	MP0003385_abnormal_body_wall	1.53116420
21	MP0000678_abnormal_parathyroid_gland	1.48766201
22	MP0001299_abnormal_eye_distance/	1.46232758
23	MP0005410_abnormal_fertilization	1.45809537
24	MP0001346_abnormal_lacrimal_gland	1.44887710
25	MP0004233_abnormal_muscle_weight	1.44250036
26	MP0005377_hearing/vestibular/ear_phenot	1.39960971
27	MP0003878_abnormal_ear_physiology	1.39960971
28	MP0001502_abnormal_circadian_rhythm	1.37190545
29	MP0005423_abnormal_somatic_nervous	1.36185232
30	MP0004858_abnormal_nervous_system	1.35990692
31	MP0000534_abnormal_ureter_morphology	1.31471140
32	MP0005623_abnormal_meninges_morphology	1.29629176
33	MP0001664_abnormal_digestion	1.29214588
34	MP0005499_abnormal_olfactory_system	1.24809888
35	MP0005394_taste/olfaction_phenotype	1.24809888
36	MP0005330_cardiomyopathy	1.23760200
37	MP0003935_abnormal_craniofacial_develop	1.22845567
38	MP0003942_abnormal_urinary_system	1.20264353
39	MP0002735_abnormal_chemical_nociception	1.19976016
40	MP0002822_catalepsy	1.17021458
41	MP0001529_abnormal_vocalization	1.16911746
42	MP0009250_abnormal_appendicular_skeleto	1.16129096
43	MP0005187_abnormal_penis_morphology	1.15325463
44	MP0001968_abnormal_touch/_nociception	1.13949072
45	MP0005174_abnormal_tail_pigmentation	1.13862151
46	MP0005248_abnormal_Harderian_gland	1.13479211
47	MP0004043_abnormal_pH_regulation	1.12705605
48	MP0003453_abnormal_keratinocyte_physiol	1.11200494
49	MP0000013_abnormal_adipose_tissue	1.10282313
50	MP0000747_muscle_weakness	1.10239094
51	MP0000762_abnormal_tongue_morphology	1.07568555
52	MP0001270_distended_abdomen	1.07106156
53	MP0004859_abnormal_synaptic_plasticity	1.06847614
54	MP0010368_abnormal_lymphatic_system	1.06463226
55	MP0000778_abnormal_nervous_system	1.05790785
56	MP0004197_abnormal_fetal_growth/weight/	1.04347061
57	MP0002233_abnormal_nose_morphology	1.03316445
58	MP0000733_abnormal_muscle_development	1.02152814
59	MP0003861_abnormal_nervous_system	1.02101859
60	MP0003755_abnormal_palate_morphology	1.00103421
61	MP0005501_abnormal_skin_physiology	0.99626678
62	MP0002108_abnormal_muscle_morphology	0.99596290
63	MP0003937_abnormal_limbs/digits/tail_de	0.98354484
64	MP0003698_abnormal_male_reproductive	0.97820373
65	MP0000003_abnormal_adipose_tissue	0.97144463
66	MP0003115_abnormal_respiratory_system	0.95577064
67	MP0004084_abnormal_cardiac_muscle	0.92853047
68	MP0000049_abnormal_middle_ear	0.92156022
69	MP0000750_abnormal_muscle_regeneration	0.92055017
70	MP0002132_abnormal_respiratory_system	0.91339716
71	MP0002116_abnormal_craniofacial_bone	0.90999069
72	MP0002085_abnormal_embryonic_tissue	0.90275261
73	MP0003091_abnormal_cell_migration	0.90032067
74	MP0001756_abnormal_urination	0.89688606
75	MP0004087_abnormal_muscle_fiber	0.89546073
76	MP0005083_abnormal_biliary_tract	0.89334416
77	MP0002796_impaired_skin_barrier	0.88742367
78	MP0004264_abnormal_extraembryonic_tissu	0.88308000
79	MP0000579_abnormal_nail_morphology	0.88069330
80	MP0001986_abnormal_taste_sensitivity	0.87882028
81	MP0002114_abnormal_axial_skeleton	0.85491804
82	MP0000759_abnormal_skeletal_muscle	0.83366106
83	MP0003077_abnormal_cell_cycle	0.82835752
84	MP0008770_decreased_survivor_rate	0.82478896
85	MP0000462_abnormal_digestive_system	0.81936147
86	MP0000432_abnormal_head_morphology	0.81375202
87	MP0002184_abnormal_innervation	0.81258752
88	MP0005503_abnormal_tendon_morphology	0.81127986
89	MP0003111_abnormal_nucleus_morphology	0.80579604
90	MP0010630_abnormal_cardiac_muscle	0.80153183
91	MP0004381_abnormal_hair_follicle	0.78947100
92	MP0002081_perinatal_lethality	0.77946731
93	MP0000955_abnormal_spinal_cord	0.76884254
94	MP0002932_abnormal_joint_morphology	0.76168371
95	MP0001929_abnormal_gametogenesis	0.75755641
96	MP0004036_abnormal_muscle_relaxation	0.75621008
97	MP0002084_abnormal_developmental_patter	0.74412033
98	MP0008789_abnormal_olfactory_epithelium	0.73897609
99	MP0003119_abnormal_digestive_system	0.73584815
100	MP0000749_muscle_degeneration	0.72983118

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Facial hemangioma (HP:0000329)	4.08733639
2	Ulnar bowing (HP:0003031)	3.97033021
3	Abnormal respiratory motile cilium morphology (HP:0005938)	3.50283510
4	Abnormal respiratory epithelium morphology (HP:0012253)	3.50283510
5	Abnormal ciliary motility (HP:0012262)	3.34966945
6	Absent/shortened dynein arms (HP:0200106)	3.32818638
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.32818638
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.13082298
9	Abnormal respiratory motile cilium physiology (HP:0012261)	3.07871853
10	Abnormality of the intrinsic pathway (HP:0010989)	2.96191031
11	Turricephaly (HP:0000262)	2.93188945
12	Thin bony cortex (HP:0002753)	2.92207701
13	High anterior hairline (HP:0009890)	2.88833114
14	Intestinal fistula (HP:0100819)	2.72128486
15	Abnormality of the columella (HP:0009929)	2.71708968
16	Capillary hemangiomas (HP:0005306)	2.71615903
17	Aortic aneurysm (HP:0004942)	2.65309618
18	Self-mutilation (HP:0000742)	2.58336016
19	Coronal craniosynostosis (HP:0004440)	2.53550882
20	Rhinitis (HP:0012384)	2.51614758
21	Rib fusion (HP:0000902)	2.46973820
22	Hemorrhage of the eye (HP:0011885)	2.42695362
23	Popliteal pterygium (HP:0009756)	2.41957354
24	Vaginal fistula (HP:0004320)	2.40539941
25	Rectovaginal fistula (HP:0000143)	2.36271786
26	Rectal fistula (HP:0100590)	2.36271786
27	Protruding tongue (HP:0010808)	2.28904613
28	Poikiloderma (HP:0001029)	2.28472829
29	Hyperacusis (HP:0010780)	2.28117883
30	Squamous cell carcinoma (HP:0002860)	2.21760823
31	Shallow orbits (HP:0000586)	2.21299888
32	Short chin (HP:0000331)	2.21026738
33	Testicular atrophy (HP:0000029)	2.20690880
34	Thin ribs (HP:0000883)	2.20270483
35	Anteriorly placed anus (HP:0001545)	2.16858222
36	Germ cell neoplasia (HP:0100728)	2.16368919
37	Nasal polyposis (HP:0100582)	2.13978959
38	Broad face (HP:0000283)	2.11828110
39	Infertility (HP:0000789)	2.10096132
40	Neoplasm of the heart (HP:0100544)	2.09705380
41	Chronic hepatic failure (HP:0100626)	2.08590369
42	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.07447214
43	Hypoplastic nipples (HP:0002557)	2.05579922
44	Bronchomalacia (HP:0002780)	2.05511463
45	Annular pancreas (HP:0001734)	2.04871501
46	Lip pit (HP:0100267)	2.03306390
47	Dyschromatopsia (HP:0007641)	2.01773180
48	Atelectasis (HP:0100750)	1.98901358
49	Aplasia of the musculature (HP:0100854)	1.97223932
50	Patellar aplasia (HP:0006443)	1.95441453
51	Male infertility (HP:0003251)	1.93038904
52	Tubulointerstitial nephritis (HP:0001970)	1.92720813
53	Dysmetric saccades (HP:0000641)	1.90011417
54	Broad distal phalanx of finger (HP:0009836)	1.89251385
55	Absent radius (HP:0003974)	1.88983046
56	Aplasia involving bones of the upper limbs (HP:0009823)	1.87513612
57	Aplasia of the phalanges of the hand (HP:0009802)	1.87513612
58	Aplasia involving bones of the extremities (HP:0009825)	1.87513612
59	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.86208163
60	Bowed forearm bones (HP:0003956)	1.83386794
61	Bowing of the arm (HP:0006488)	1.83386794
62	Choanal stenosis (HP:0000452)	1.82310038
63	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81635796
64	Chronic bronchitis (HP:0004469)	1.77291743
65	Short humerus (HP:0005792)	1.74567741
66	Spina bifida occulta (HP:0003298)	1.73566148
67	Occipital encephalocele (HP:0002085)	1.72907573
68	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.71931146
69	Abnormality of the nasal mucosa (HP:0000433)	1.70964407
70	Absent forearm bone (HP:0003953)	1.70797103
71	Aplasia involving forearm bones (HP:0009822)	1.70797103
72	Renovascular hypertension (HP:0100817)	1.70461565
73	Abnormality of the fingertips (HP:0001211)	1.67743335
74	Alacrima (HP:0000522)	1.67548378
75	Abnormality of the dental root (HP:0006486)	1.67073980
76	Taurodontia (HP:0000679)	1.67073980
77	Abnormality of permanent molar morphology (HP:0011071)	1.67073980
78	Bronchiectasis (HP:0002110)	1.64939824
79	Flattened epiphyses (HP:0003071)	1.59960457
80	Open mouth (HP:0000194)	1.59028735
81	Spinal rigidity (HP:0003306)	1.59023708
82	Cerebellar dysplasia (HP:0007033)	1.57813849
83	Absent speech (HP:0001344)	1.57041114
84	Pterygium (HP:0001059)	1.57017832
85	Mesangial abnormality (HP:0001966)	1.56909045
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.56756948
87	Renal dysplasia (HP:0000110)	1.55728009
88	Abnormality of molar (HP:0011077)	1.54903192
89	Abnormality of molar morphology (HP:0011070)	1.54903192
90	Bifid scrotum (HP:0000048)	1.52934686
91	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.52580836
92	Short 4th metacarpal (HP:0010044)	1.52580836
93	Genetic anticipation (HP:0003743)	1.52294814
94	Myopathic facies (HP:0002058)	1.51984054
95	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.50686221
96	Lymphangioma (HP:0100764)	1.49370409
97	Skull defect (HP:0001362)	1.49275629
98	Short nail (HP:0001799)	1.49260100
99	Abnormality of the dental pulp (HP:0006479)	1.49209355
100	Cutaneous finger syndactyly (HP:0010554)	1.47570531

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.12717552
2	TRIB3	4.30992589
3	EEF2K	3.93727608
4	PINK1	3.38282833
5	ICK	2.90147128
6	CDK12	2.77255042
7	NEK2	2.46012985
8	LATS1	2.44664985
9	MYLK	2.05124261
10	SIK1	2.02520907
11	AKT3	1.85728249
12	PKN2	1.85107305
13	MAP3K10	1.84673297
14	MAP2K7	1.71604651
15	PRKD3	1.61660992
16	LATS2	1.60965841
17	SIK2	1.60422276
18	EPHA2	1.60008149
19	BRD4	1.54522087
20	MARK3	1.54258821
21	TLK1	1.52608438
22	MTOR	1.44804003
23	MST1R	1.39093529
24	WNK3	1.31281273
25	RPS6KA2	1.29685428
26	SGK494	1.27336319
27	SGK223	1.27336319
28	MUSK	1.24906909
29	MAPKAPK3	1.16089416
30	EPHA3	1.14597704
31	CAMK1D	1.13033536
32	TTN	1.12948978
33	PDGFRA	1.09099424
34	CAMK1G	1.08665717
35	CCNB1	1.05376819
36	CDC42BPA	1.05373996
37	MARK2	1.04220600
38	MARK1	1.00356944
39	MAP3K6	0.97139861
40	PAK2	0.96015843
41	CSNK1A1L	0.95455966
42	WNK4	0.91556340
43	FGFR2	0.88583794
44	STK38	0.85308383
45	MAP3K7	0.85191417
46	MET	0.84773754
47	RET	0.78606518
48	STK38L	0.77968143
49	SMG1	0.77689079
50	SGK2	0.77171852
51	MELK	0.76054483
52	MAP3K13	0.75569470
53	CASK	0.75393937
54	PDPK1	0.75280288
55	ILK	0.71773119
56	PRKAA1	0.71047964
57	RPS6KB1	0.70499780
58	RPS6KL1	0.67884696
59	RPS6KC1	0.67884696
60	IRAK2	0.67437641
61	DYRK3	0.66995327
62	FGFR4	0.64563762
63	CDK3	0.64359774
64	SGK3	0.62853899
65	RPS6KA5	0.62241017
66	MAP3K4	0.62081107
67	INSRR	0.60840703
68	CDK8	0.60017014
69	RPS6KA6	0.58025957
70	NME1	0.55708573
71	RPS6KB2	0.53204131
72	MAP3K9	0.51086342
73	PRKD2	0.49469527
74	TYRO3	0.49191623
75	MAPK11	0.48607100
76	EPHB1	0.47464144
77	MAPK12	0.47277369
78	OBSCN	0.47111545
79	PAK1	0.46655014
80	CSNK1G3	0.42628888
81	ROCK1	0.41759641
82	LMTK2	0.41163076
83	RPS6KA1	0.41149617
84	CDK7	0.40981254
85	ZAK	0.40452607
86	CDK1	0.39213636
87	MAPK8	0.39142761
88	AURKA	0.38961351
89	MAP2K4	0.38916260
90	WNK1	0.37769088
91	ARAF	0.36378013
92	CHEK2	0.36237868
93	AKT2	0.34911502
94	ATR	0.34177027
95	RIPK1	0.34056391
96	GSK3B	0.34050570
97	CDK4	0.33354705
98	PTK2	0.32418040
99	ATM	0.31281279
100	EPHA4	0.31014621

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.76117500
2	Sulfur relay system_Homo sapiens_hsa04122	2.64224851
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.34504945
4	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.75812756
5	Lysine degradation_Homo sapiens_hsa00310	1.68387114
6	Gap junction_Homo sapiens_hsa04540	1.63067065
7	mTOR signaling pathway_Homo sapiens_hsa04150	1.53600732
8	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.52601197
9	Basal cell carcinoma_Homo sapiens_hsa05217	1.48057475
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.43102803
11	Axon guidance_Homo sapiens_hsa04360	1.39469440
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.37194033
13	Taste transduction_Homo sapiens_hsa04742	1.33602166
14	ABC transporters_Homo sapiens_hsa02010	1.33207385
15	Notch signaling pathway_Homo sapiens_hsa04330	1.32467142
16	Circadian rhythm_Homo sapiens_hsa04710	1.32157361
17	Hippo signaling pathway_Homo sapiens_hsa04390	1.28150199
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27946366
19	Alcoholism_Homo sapiens_hsa05034	1.26247618
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.25116855
21	Endometrial cancer_Homo sapiens_hsa05213	1.23422762
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21386515
23	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.19367568
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.17821846
25	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.17468274
26	Melanogenesis_Homo sapiens_hsa04916	1.16708441
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.15767738
28	ECM-receptor interaction_Homo sapiens_hsa04512	1.15671169
29	AMPK signaling pathway_Homo sapiens_hsa04152	1.09170499
30	Choline metabolism in cancer_Homo sapiens_hsa05231	1.08749742
31	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.06472337
32	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.04165082
33	Tight junction_Homo sapiens_hsa04530	1.03964219
34	Prostate cancer_Homo sapiens_hsa05215	1.02425270
35	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.02000040
36	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.00173594
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98180470
38	mRNA surveillance pathway_Homo sapiens_hsa03015	0.97404139
39	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.95570662
40	Adherens junction_Homo sapiens_hsa04520	0.92931226
41	Focal adhesion_Homo sapiens_hsa04510	0.92820975
42	VEGF signaling pathway_Homo sapiens_hsa04370	0.92770479
43	ErbB signaling pathway_Homo sapiens_hsa04012	0.89986836
44	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.89549767
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.89246933
46	Non-small cell lung cancer_Homo sapiens_hsa05223	0.88733773
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87764179
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.87708361
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.86650710
50	Olfactory transduction_Homo sapiens_hsa04740	0.86598737
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.85612404
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84742901
53	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84298942
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.83595758
55	MicroRNAs in cancer_Homo sapiens_hsa05206	0.82263831
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81999397
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81775580
58	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81375621
59	Insulin signaling pathway_Homo sapiens_hsa04910	0.80349030
60	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.80068412
61	Nicotine addiction_Homo sapiens_hsa05033	0.79809686
62	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.77040868
63	Cocaine addiction_Homo sapiens_hsa05030	0.76574535
64	Small cell lung cancer_Homo sapiens_hsa05222	0.75208589
65	Glioma_Homo sapiens_hsa05214	0.74265237
66	Melanoma_Homo sapiens_hsa05218	0.74187761
67	Circadian entrainment_Homo sapiens_hsa04713	0.69998927
68	Bladder cancer_Homo sapiens_hsa05219	0.69659987
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.69291679
70	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.68958092
71	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.68024857
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.67624871
73	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.66760646
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.66047087
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64765309
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63902738
77	Insulin resistance_Homo sapiens_hsa04931	0.63163131
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61574324
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.60308448
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60098478
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.60035346
82	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.59195039
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56464655
84	Cell cycle_Homo sapiens_hsa04110	0.56433753
85	Cholinergic synapse_Homo sapiens_hsa04725	0.56286030
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.55388937
87	Oocyte meiosis_Homo sapiens_hsa04114	0.53616811
88	Apoptosis_Homo sapiens_hsa04210	0.53163046
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.52722922
90	FoxO signaling pathway_Homo sapiens_hsa04068	0.52486380
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51875080
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51203532
93	Proteoglycans in cancer_Homo sapiens_hsa05205	0.50919496
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50422817
95	GnRH signaling pathway_Homo sapiens_hsa04912	0.49401988
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48204656
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47413758
98	Pathways in cancer_Homo sapiens_hsa05200	0.46958542
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46498269
100	Colorectal cancer_Homo sapiens_hsa05210	0.46180652

CSPG4P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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