ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.08642396
2	fucose catabolic process (GO:0019317)	4.30835060
3	L-fucose metabolic process (GO:0042354)	4.30835060
4	L-fucose catabolic process (GO:0042355)	4.30835060
5	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.90025679
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.90025679
7	regulation of translation, ncRNA-mediated (GO:0045974)	3.90025679
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73959547
9	tryptophan catabolic process (GO:0006569)	3.70602769
10	indole-containing compound catabolic process (GO:0042436)	3.70602769
11	indolalkylamine catabolic process (GO:0046218)	3.70602769
12	indolalkylamine metabolic process (GO:0006586)	3.67762384
13	cellular ketone body metabolic process (GO:0046950)	3.65930271
14	kynurenine metabolic process (GO:0070189)	3.65288225
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.49570997
16	response to pheromone (GO:0019236)	3.36555429
17	regulation of hippo signaling (GO:0035330)	3.33252282
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.24360109
19	ketone body metabolic process (GO:1902224)	3.20358879
20	nonmotile primary cilium assembly (GO:0035058)	3.17666933
21	gamma-aminobutyric acid transport (GO:0015812)	3.11545610
22	tryptophan metabolic process (GO:0006568)	3.10577988
23	interkinetic nuclear migration (GO:0022027)	3.07327303
24	detection of light stimulus involved in visual perception (GO:0050908)	3.05323454
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.05323454
26	axoneme assembly (GO:0035082)	3.00652123
27	kidney morphogenesis (GO:0060993)	2.96153899
28	epithelial cilium movement (GO:0003351)	2.95497743
29	neural tube formation (GO:0001841)	2.89708633
30	cilium movement (GO:0003341)	2.88608337
31	indole-containing compound metabolic process (GO:0042430)	2.87242359
32	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.86946054
33	primary amino compound metabolic process (GO:1901160)	2.85988264
34	cilium organization (GO:0044782)	2.85200066
35	photoreceptor cell maintenance (GO:0045494)	2.84573087
36	neuronal action potential (GO:0019228)	2.82221173
37	cilium assembly (GO:0042384)	2.79227747
38	spinal cord motor neuron differentiation (GO:0021522)	2.77573497
39	cornea development in camera-type eye (GO:0061303)	2.73656663
40	nephron tubule morphogenesis (GO:0072078)	2.71528404
41	nephron epithelium morphogenesis (GO:0072088)	2.71528404
42	cilium morphogenesis (GO:0060271)	2.69116638
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.68161482
44	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.66472266
45	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.64726551
46	reflex (GO:0060004)	2.63865000
47	serotonin metabolic process (GO:0042428)	2.63275288
48	cAMP catabolic process (GO:0006198)	2.62528060
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.58347452
50	membrane depolarization during action potential (GO:0086010)	2.57947707
51	behavioral response to ethanol (GO:0048149)	2.54279183
52	cellular response to sterol (GO:0036315)	2.53793323
53	positive regulation of CREB transcription factor activity (GO:0032793)	2.53624326
54	somite development (GO:0061053)	2.53522444
55	sulfation (GO:0051923)	2.51198211
56	protein K11-linked deubiquitination (GO:0035871)	2.50156701
57	protein localization to synapse (GO:0035418)	2.49485691
58	regulation of action potential (GO:0098900)	2.48025681
59	protein polyglutamylation (GO:0018095)	2.46252663
60	retinal cone cell development (GO:0046549)	2.45950066
61	inner ear receptor stereocilium organization (GO:0060122)	2.45625921
62	peristalsis (GO:0030432)	2.44564229
63	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.44023358
64	protein import into peroxisome matrix (GO:0016558)	2.43845840
65	protein localization to cilium (GO:0061512)	2.42602356
66	presynaptic membrane assembly (GO:0097105)	2.41836710
67	regulation of gene silencing by RNA (GO:0060966)	2.41617024
68	regulation of posttranscriptional gene silencing (GO:0060147)	2.41617024
69	regulation of gene silencing by miRNA (GO:0060964)	2.41617024
70	transmission of nerve impulse (GO:0019226)	2.40738593
71	cyclic nucleotide catabolic process (GO:0009214)	2.40039955
72	retinal ganglion cell axon guidance (GO:0031290)	2.39831020
73	startle response (GO:0001964)	2.39732943
74	limb development (GO:0060173)	2.39393695
75	appendage development (GO:0048736)	2.39393695
76	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.37732327
77	urinary tract smooth muscle contraction (GO:0014848)	2.37281235
78	establishment of protein localization to Golgi (GO:0072600)	2.36644547
79	water-soluble vitamin biosynthetic process (GO:0042364)	2.35345210
80	oxidative demethylation (GO:0070989)	2.33292943
81	reciprocal DNA recombination (GO:0035825)	2.32738253
82	reciprocal meiotic recombination (GO:0007131)	2.32738253
83	spinal cord development (GO:0021510)	2.31511554
84	cellular component assembly involved in morphogenesis (GO:0010927)	2.30791179
85	pyrimidine nucleobase catabolic process (GO:0006208)	2.30405475
86	smoothened signaling pathway (GO:0007224)	2.29676974
87	dendritic spine morphogenesis (GO:0060997)	2.29495432
88	piRNA metabolic process (GO:0034587)	2.28990316
89	negative regulation of systemic arterial blood pressure (GO:0003085)	2.28830980
90	renal tubule morphogenesis (GO:0061333)	2.28051814
91	fucosylation (GO:0036065)	2.26850191
92	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.26559381
93	monoubiquitinated protein deubiquitination (GO:0035520)	2.26519759
94	DNA methylation involved in gamete generation (GO:0043046)	2.26503883
95	respiratory chain complex IV assembly (GO:0008535)	2.26443854
96	postsynaptic membrane organization (GO:0001941)	2.26377711
97	snRNA transcription (GO:0009301)	2.26059376
98	double-strand break repair via homologous recombination (GO:0000724)	2.25114245
99	central nervous system neuron axonogenesis (GO:0021955)	2.24935770
100	phasic smooth muscle contraction (GO:0014821)	2.24585911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.09986339
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69309068
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.36186573
4	VDR_22108803_ChIP-Seq_LS180_Human	3.19883610
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.15640664
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62551454
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47347771
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30120485
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28074167
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.24544258
11	FUS_26573619_Chip-Seq_HEK293_Human	2.16030367
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.13247580
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12289434
14	EWS_26573619_Chip-Seq_HEK293_Human	2.02670045
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01791191
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.94715173
17	P300_19829295_ChIP-Seq_ESCs_Human	1.94535219
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.94011276
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93449784
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92587838
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87611632
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.86465157
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.81707633
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81182672
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78862074
26	STAT3_23295773_ChIP-Seq_U87_Human	1.74906981
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.74409152
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73339111
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70904653
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68525093
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62140058
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62140058
33	TCF4_23295773_ChIP-Seq_U87_Human	1.56855264
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56299028
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55775538
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.53028331
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53014689
38	AR_25329375_ChIP-Seq_VCAP_Human	1.50668303
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47328138
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46958936
41	DROSHA_22980978_ChIP-Seq_HELA_Human	1.46243756
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45289622
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45278655
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43819939
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40503676
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40478691
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37241501
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37225591
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.36514094
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36514094
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36496301
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36372315
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32185003
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.32119298
55	TP53_16413492_ChIP-PET_HCT116_Human	1.28697135
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28599465
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26827004
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26655151
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24965295
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24615352
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22748942
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.20924684
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20262446
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20130548
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19755509
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19684209
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19319193
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.18172996
69	AHR_22903824_ChIP-Seq_MCF-7_Human	1.16883640
70	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15710621
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15313965
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15313965
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14952891
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14770215
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13723855
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.13188856
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12712597
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10640502
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09380507
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09200510
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08540307
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08385990
83	RXR_22108803_ChIP-Seq_LS180_Human	1.07341466
84	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06907315
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06649816
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04557126
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02982836
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02580046
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02563544
90	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.02277479
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00804944
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00030741
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99362591
94	KDM2B_26808549_Chip-Seq_REH_Human	0.98925365
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98732493
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97679621
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96882705
98	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.95511244
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95217422
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95217422

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.27140988
2	MP0000569_abnormal_digit_pigmentation	3.13145767
3	MP0003136_yellow_coat_color	3.05842894
4	MP0003646_muscle_fatigue	2.57974518
5	MP0008877_abnormal_DNA_methylation	2.23853441
6	MP0005551_abnormal_eye_electrophysiolog	2.23351665
7	MP0004043_abnormal_pH_regulation	2.18452472
8	MP0009046_muscle_twitch	2.06317478
9	MP0001968_abnormal_touch/_nociception	2.04552486
10	MP0002102_abnormal_ear_morphology	1.93671342
11	MP0009745_abnormal_behavioral_response	1.90079828
12	MP0005645_abnormal_hypothalamus_physiol	1.88338858
13	MP0005646_abnormal_pituitary_gland	1.86549123
14	MP0002837_dystrophic_cardiac_calcinosis	1.77580625
15	MP0002653_abnormal_ependyma_morphology	1.75055898
16	MP0001501_abnormal_sleep_pattern	1.72452929
17	MP0008057_abnormal_DNA_replication	1.72409354
18	MP0004885_abnormal_endolymph	1.72037315
19	MP0002638_abnormal_pupillary_reflex	1.71531412
20	MP0004142_abnormal_muscle_tone	1.67401553
21	MP0001486_abnormal_startle_reflex	1.66987015
22	MP0002938_white_spotting	1.65522291
23	MP0001485_abnormal_pinna_reflex	1.63651702
24	MP0005174_abnormal_tail_pigmentation	1.62385718
25	MP0000631_abnormal_neuroendocrine_gland	1.59330442
26	MP0004145_abnormal_muscle_electrophysio	1.57934113
27	MP0002272_abnormal_nervous_system	1.57343811
28	MP0002736_abnormal_nociception_after	1.55173255
29	MP0005253_abnormal_eye_physiology	1.53394324
30	MP0006276_abnormal_autonomic_nervous	1.53241857
31	MP0008872_abnormal_physiological_respon	1.50417319
32	MP0003880_abnormal_central_pattern	1.50380895
33	MP0000427_abnormal_hair_cycle	1.49918855
34	MP0006072_abnormal_retinal_apoptosis	1.49437920
35	MP0004147_increased_porphyrin_level	1.48194940
36	MP0002572_abnormal_emotion/affect_behav	1.46792308
37	MP0004133_heterotaxia	1.44682173
38	MP0002064_seizures	1.44030854
39	MP0000778_abnormal_nervous_system	1.41596220
40	MP0002557_abnormal_social/conspecific_i	1.38638599
41	MP0002735_abnormal_chemical_nociception	1.38412800
42	MP0002928_abnormal_bile_duct	1.38066820
43	MP0003890_abnormal_embryonic-extraembry	1.34810456
44	MP0002063_abnormal_learning/memory/cond	1.32215923
45	MP0003635_abnormal_synaptic_transmissio	1.31713111
46	MP0000383_abnormal_hair_follicle	1.31605408
47	MP0001986_abnormal_taste_sensitivity	1.30486610
48	MP0002876_abnormal_thyroid_physiology	1.30334454
49	MP0002067_abnormal_sensory_capabilities	1.26171591
50	MP0004742_abnormal_vestibular_system	1.23843089
51	MP0004924_abnormal_behavior	1.22811788
52	MP0005386_behavior/neurological_phenoty	1.22811788
53	MP0001984_abnormal_olfaction	1.19898284
54	MP0003937_abnormal_limbs/digits/tail_de	1.19793608
55	MP0001970_abnormal_pain_threshold	1.19608787
56	MP0004215_abnormal_myocardial_fiber	1.19276586
57	MP0002234_abnormal_pharynx_morphology	1.17715147
58	MP0005171_absent_coat_pigmentation	1.14335666
59	MP0006292_abnormal_olfactory_placode	1.14282575
60	MP0008961_abnormal_basal_metabolism	1.13577009
61	MP0002160_abnormal_reproductive_system	1.10501419
62	MP0010386_abnormal_urinary_bladder	1.10365469
63	MP0004130_abnormal_muscle_cell	1.06177932
64	MP0002751_abnormal_autonomic_nervous	1.05120297
65	MP0000538_abnormal_urinary_bladder	1.04993695
66	MP0005423_abnormal_somatic_nervous	1.03962067
67	MP0000372_irregular_coat_pigmentation	1.02653201
68	MP0005187_abnormal_penis_morphology	1.00366754
69	MP0005195_abnormal_posterior_eye	0.99960647
70	MP0005670_abnormal_white_adipose	0.99474778
71	MP0002734_abnormal_mechanical_nocicepti	0.99432690
72	MP0002752_abnormal_somatic_nervous	0.99379585
73	MP0000955_abnormal_spinal_cord	0.99170796
74	MP0002733_abnormal_thermal_nociception	0.98455427
75	MP0003137_abnormal_impulse_conducting	0.98330076
76	MP0000026_abnormal_inner_ear	0.97689141
77	MP0002184_abnormal_innervation	0.97538384
78	MP0003119_abnormal_digestive_system	0.96562923
79	MP0008775_abnormal_heart_ventricle	0.93975727
80	MP0003787_abnormal_imprinting	0.93880953
81	MP0003698_abnormal_male_reproductive	0.89895464
82	MP0000230_abnormal_systemic_arterial	0.89867064
83	MP0008995_early_reproductive_senescence	0.87518450
84	MP0002882_abnormal_neuron_morphology	0.86555774
85	MP0008875_abnormal_xenobiotic_pharmacok	0.86311507
86	MP0001502_abnormal_circadian_rhythm	0.85069189
87	MP0005167_abnormal_blood-brain_barrier	0.83883686
88	MP0004085_abnormal_heartbeat	0.83190285
89	MP0002095_abnormal_skin_pigmentation	0.82433921
90	MP0003045_fibrosis	0.81945783
91	MP0005084_abnormal_gallbladder_morpholo	0.81641071
92	MP0005503_abnormal_tendon_morphology	0.80412699
93	MP0001963_abnormal_hearing_physiology	0.79427028
94	MP0002229_neurodegeneration	0.79009363
95	MP0001529_abnormal_vocalization	0.78556645
96	MP0005389_reproductive_system_phenotype	0.77649850
97	MP0001324_abnormal_eye_pigmentation	0.76952572
98	MP0003718_maternal_effect	0.76208720
99	MP0004859_abnormal_synaptic_plasticity	0.74266974
100	MP0003283_abnormal_digestive_organ	0.73950449

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.53565848
2	Abnormality of midbrain morphology (HP:0002418)	4.21771936
3	Molar tooth sign on MRI (HP:0002419)	4.21771936
4	Pancreatic fibrosis (HP:0100732)	4.17077325
5	True hermaphroditism (HP:0010459)	4.03831459
6	Hyperventilation (HP:0002883)	3.95563115
7	Nephronophthisis (HP:0000090)	3.76384084
8	Type II lissencephaly (HP:0007260)	3.74151226
9	Genetic anticipation (HP:0003743)	3.48622953
10	Chronic hepatic failure (HP:0100626)	3.37213334
11	Abnormality of the renal medulla (HP:0100957)	3.33106570
12	Congenital stationary night blindness (HP:0007642)	3.23431748
13	Progressive cerebellar ataxia (HP:0002073)	3.05731141
14	Abnormality of the renal cortex (HP:0011035)	3.02845677
15	Cystic liver disease (HP:0006706)	3.01967623
16	Cerebellar dysplasia (HP:0007033)	3.01533547
17	Tubular atrophy (HP:0000092)	2.98342866
18	Gaze-evoked nystagmus (HP:0000640)	2.97804378
19	Medial flaring of the eyebrow (HP:0010747)	2.88026669
20	Large for gestational age (HP:0001520)	2.82333418
21	Protruding tongue (HP:0010808)	2.82151865
22	Inability to walk (HP:0002540)	2.78706051
23	Attenuation of retinal blood vessels (HP:0007843)	2.64611407
24	Febrile seizures (HP:0002373)	2.59473354
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.56029971
26	Broad-based gait (HP:0002136)	2.55965976
27	Abnormal drinking behavior (HP:0030082)	2.55539748
28	Polydipsia (HP:0001959)	2.55539748
29	Patellar aplasia (HP:0006443)	2.52385007
30	Clumsiness (HP:0002312)	2.52262719
31	Lissencephaly (HP:0001339)	2.48786755
32	Hypoplasia of the pons (HP:0012110)	2.46440267
33	Abnormality of the pons (HP:0007361)	2.44627948
34	Concave nail (HP:0001598)	2.39985132
35	Gait imbalance (HP:0002141)	2.38202936
36	Decreased circulating renin level (HP:0003351)	2.33529309
37	Aplasia/Hypoplasia of the patella (HP:0006498)	2.32436704
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30311711
39	Absent/shortened dynein arms (HP:0200106)	2.30311711
40	Birth length less than 3rd percentile (HP:0003561)	2.29976803
41	Congenital primary aphakia (HP:0007707)	2.24747546
42	Furrowed tongue (HP:0000221)	2.24275305
43	Congenital hepatic fibrosis (HP:0002612)	2.23177616
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23036153
45	Sclerocornea (HP:0000647)	2.22766537
46	Bile duct proliferation (HP:0001408)	2.21224657
47	Abnormal biliary tract physiology (HP:0012439)	2.21224657
48	Anencephaly (HP:0002323)	2.14694068
49	Abnormality of alanine metabolism (HP:0010916)	2.14300773
50	Hyperalaninemia (HP:0003348)	2.14300773
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14300773
52	Genital tract atresia (HP:0001827)	2.13982161
53	Increased corneal curvature (HP:0100692)	2.12058245
54	Keratoconus (HP:0000563)	2.12058245
55	Abnormality of the renal collecting system (HP:0004742)	2.11557652
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.09570781
57	Absent speech (HP:0001344)	2.09254041
58	Fair hair (HP:0002286)	2.06671603
59	Abolished electroretinogram (ERG) (HP:0000550)	2.06353915
60	Progressive inability to walk (HP:0002505)	2.05744259
61	Vaginal atresia (HP:0000148)	2.04524007
62	Nephrogenic diabetes insipidus (HP:0009806)	2.03240903
63	Poor coordination (HP:0002370)	2.03188876
64	Postaxial foot polydactyly (HP:0001830)	2.02678005
65	Severe muscular hypotonia (HP:0006829)	1.99368323
66	Duplicated collecting system (HP:0000081)	1.96967599
67	Polyuria (HP:0000103)	1.96429174
68	Chorioretinal atrophy (HP:0000533)	1.96240878
69	Pachygyria (HP:0001302)	1.95893647
70	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.95638483
71	Male pseudohermaphroditism (HP:0000037)	1.94119298
72	Partial agenesis of the corpus callosum (HP:0001338)	1.93629368
73	Decreased central vision (HP:0007663)	1.92586360
74	Pendular nystagmus (HP:0012043)	1.91478252
75	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.90041060
76	Focal seizures (HP:0007359)	1.89136911
77	Renal cortical cysts (HP:0000803)	1.87953086
78	Dandy-Walker malformation (HP:0001305)	1.86603347
79	Bulbous nose (HP:0000414)	1.85167609
80	Retinal dysplasia (HP:0007973)	1.85114818
81	Hypoplastic ischia (HP:0003175)	1.82459803
82	Widely spaced teeth (HP:0000687)	1.81646456
83	Drooling (HP:0002307)	1.81516878
84	Highly arched eyebrow (HP:0002553)	1.78554747
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76653010
86	Hemiparesis (HP:0001269)	1.76586330
87	Postaxial hand polydactyly (HP:0001162)	1.76422214
88	Abnormal ciliary motility (HP:0012262)	1.75538412
89	Hypothermia (HP:0002045)	1.74887857
90	Tachypnea (HP:0002789)	1.74667393
91	Tubulointerstitial nephritis (HP:0001970)	1.74562154
92	Short foot (HP:0001773)	1.73662541
93	Optic nerve hypoplasia (HP:0000609)	1.73635817
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.72703413
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72703413
96	Preaxial hand polydactyly (HP:0001177)	1.70821892
97	Hypoplastic labia majora (HP:0000059)	1.70684561
98	Dialeptic seizures (HP:0011146)	1.69380439
99	Small hand (HP:0200055)	1.68908462
100	Atonic seizures (HP:0010819)	1.68727047

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.71091444
2	BMPR1B	3.30590982
3	ACVR1B	2.93345451
4	ADRBK2	2.90105145
5	WNK3	2.59222030
6	PNCK	2.34850303
7	CASK	2.25204807
8	WNK4	2.22901954
9	INSRR	2.14758055
10	ZAK	2.05688065
11	AKT3	1.99285181
12	MAPK13	1.98315278
13	GRK1	1.96045174
14	MAP3K4	1.85626205
15	PINK1	1.83040437
16	MAPK15	1.74525209
17	MARK1	1.65654332
18	MKNK2	1.64912289
19	TAOK3	1.53689052
20	NTRK3	1.51764710
21	STK39	1.48784636
22	CAMK1G	1.47063153
23	MAP4K2	1.45166495
24	NUAK1	1.43865051
25	DAPK2	1.43396467
26	CAMK1D	1.36278694
27	TLK1	1.34663000
28	TGFBR1	1.33066825
29	OXSR1	1.32869410
30	TNIK	1.31561568
31	ADRBK1	1.21597341
32	PAK3	1.18199990
33	PIK3CA	1.12822188
34	FGFR2	1.00925566
35	EPHA3	0.97223329
36	PRKCE	0.95371998
37	MAP2K7	0.92747278
38	MAPKAPK3	0.91292826
39	SIK2	0.90596516
40	PRKCG	0.87144825
41	CAMK1	0.85268944
42	CAMKK2	0.81969159
43	STK38L	0.79163729
44	NTRK2	0.79111356
45	BRSK2	0.77606482
46	SGK2	0.76845705
47	OBSCN	0.74943487
48	PHKG2	0.74459954
49	PHKG1	0.74459954
50	DYRK2	0.70748447
51	EPHA4	0.69263323
52	PKN1	0.69208722
53	PRKAA1	0.65911645
54	MAP3K7	0.64744404
55	WEE1	0.63528930
56	NLK	0.62291829
57	MKNK1	0.61252452
58	CSNK1A1L	0.60826108
59	PRKAA2	0.59986387
60	CSNK1G1	0.59190892
61	BCR	0.59061344
62	ERBB2	0.59026180
63	CAMK4	0.58698797
64	BRD4	0.58200563
65	CSNK1G2	0.57887613
66	WNK1	0.57497875
67	SGK223	0.57022280
68	SGK494	0.57022280
69	RPS6KA5	0.55155482
70	TRIM28	0.54602976
71	CAMK2A	0.53837078
72	STK11	0.52724400
73	PTK2B	0.52192644
74	TRPM7	0.50408581
75	TIE1	0.48634506
76	CHUK	0.48379025
77	FER	0.47593874
78	PLK2	0.46242016
79	MUSK	0.45699348
80	NEK2	0.45508367
81	VRK1	0.45465726
82	CDK3	0.45306812
83	DYRK1A	0.44857873
84	MAP2K6	0.44312425
85	RPS6KA6	0.43880615
86	PRKACA	0.41295790
87	STK3	0.40816526
88	MAP2K4	0.40758785
89	MAPKAPK5	0.40036760
90	PRKCZ	0.39561549
91	ERBB3	0.38909583
92	LATS1	0.38542314
93	CSNK1A1	0.35451493
94	CSNK1G3	0.35252069
95	CSNK1D	0.34724070
96	IRAK1	0.32876494
97	MYLK	0.32171650
98	ATM	0.31984774
99	CHEK2	0.31699388
100	ATR	0.31662076

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.76351379
2	Nicotine addiction_Homo sapiens_hsa05033	2.70315016
3	Phototransduction_Homo sapiens_hsa04744	2.49755890
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.48349325
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.39105071
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.38862385
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38667385
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.34418639
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24195348
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.09983950
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.07335931
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06858952
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06052528
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04678522
15	Taste transduction_Homo sapiens_hsa04742	1.98832586
16	ABC transporters_Homo sapiens_hsa02010	1.87623355
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75675412
18	Morphine addiction_Homo sapiens_hsa05032	1.72151316
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.70422257
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66590852
21	Homologous recombination_Homo sapiens_hsa03440	1.65590911
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.65148840
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61753987
24	Circadian entrainment_Homo sapiens_hsa04713	1.56702241
25	Insulin secretion_Homo sapiens_hsa04911	1.50716967
26	Olfactory transduction_Homo sapiens_hsa04740	1.46300008
27	GABAergic synapse_Homo sapiens_hsa04727	1.46031864
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.45911517
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43393830
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.37929790
31	Basal transcription factors_Homo sapiens_hsa03022	1.32434571
32	Serotonergic synapse_Homo sapiens_hsa04726	1.19658193
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16675205
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14698175
35	Caffeine metabolism_Homo sapiens_hsa00232	1.14228631
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13332986
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11431422
38	RNA polymerase_Homo sapiens_hsa03020	1.11060576
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.03386442
40	Propanoate metabolism_Homo sapiens_hsa00640	1.00149801
41	Lysine degradation_Homo sapiens_hsa00310	0.99577859
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99302400
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99231265
44	Salivary secretion_Homo sapiens_hsa04970	0.98985062
45	Circadian rhythm_Homo sapiens_hsa04710	0.96553722
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.95012424
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92711301
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.92533514
49	Retinol metabolism_Homo sapiens_hsa00830	0.91258232
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91152398
51	Cocaine addiction_Homo sapiens_hsa05030	0.88803982
52	One carbon pool by folate_Homo sapiens_hsa00670	0.88517848
53	Peroxisome_Homo sapiens_hsa04146	0.88070370
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87640694
55	Cholinergic synapse_Homo sapiens_hsa04725	0.85801549
56	Long-term depression_Homo sapiens_hsa04730	0.82731032
57	Histidine metabolism_Homo sapiens_hsa00340	0.82150114
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81465552
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80559266
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.78489864
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78382557
62	Amphetamine addiction_Homo sapiens_hsa05031	0.77501866
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.75600703
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.74945912
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72213003
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72077179
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.68909139
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68372133
69	RNA degradation_Homo sapiens_hsa03018	0.65246880
70	Gastric acid secretion_Homo sapiens_hsa04971	0.62583274
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61655293
72	Renin secretion_Homo sapiens_hsa04924	0.61354580
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60972188
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.60896408
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60276115
76	Oxidative phosphorylation_Homo sapiens_hsa00190	0.59060042
77	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.55314290
78	Sulfur relay system_Homo sapiens_hsa04122	0.54595134
79	Regulation of autophagy_Homo sapiens_hsa04140	0.53403676
80	Axon guidance_Homo sapiens_hsa04360	0.53061153
81	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.50884500
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50682153
83	Mineral absorption_Homo sapiens_hsa04978	0.50327438
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49792683
85	Protein export_Homo sapiens_hsa03060	0.49421873
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.49241009
87	Huntingtons disease_Homo sapiens_hsa05016	0.47633748
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44699765
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.44553095
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.43989113
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43483945
92	Purine metabolism_Homo sapiens_hsa00230	0.42843992
93	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41236007
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39063216
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38720194
96	Pancreatic secretion_Homo sapiens_hsa04972	0.38387549
97	Metabolic pathways_Homo sapiens_hsa01100	0.33269165
98	Bile secretion_Homo sapiens_hsa04976	0.32459145
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30735575
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30086688

CSPG4P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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