CSPG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.07130435
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.89930154
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.66129676
4neuron cell-cell adhesion (GO:0007158)5.65251404
5vocalization behavior (GO:0071625)5.61588929
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56961150
7synaptic vesicle maturation (GO:0016188)5.37620965
8central nervous system myelination (GO:0022010)5.24662126
9axon ensheathment in central nervous system (GO:0032291)5.24662126
10neurotransmitter-gated ion channel clustering (GO:0072578)5.22854035
11postsynaptic membrane organization (GO:0001941)5.07915599
12protein localization to synapse (GO:0035418)5.07123769
13regulation of glutamate receptor signaling pathway (GO:1900449)5.05373433
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.75002856
15synaptic vesicle exocytosis (GO:0016079)4.70713229
16potassium ion import (GO:0010107)4.68404327
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67957820
18regulation of synaptic vesicle exocytosis (GO:2000300)4.59462837
19exploration behavior (GO:0035640)4.58859328
20potassium ion homeostasis (GO:0055075)4.57917823
21presynaptic membrane assembly (GO:0097105)4.57885847
22glutamate secretion (GO:0014047)4.56012293
23gamma-aminobutyric acid transport (GO:0015812)4.54652894
24layer formation in cerebral cortex (GO:0021819)4.48451878
25dendritic spine morphogenesis (GO:0060997)4.43538847
26neuronal action potential propagation (GO:0019227)4.34858403
27cerebellar granule cell differentiation (GO:0021707)4.27912548
28regulation of neuronal synaptic plasticity (GO:0048168)4.27100379
29synaptic transmission, glutamatergic (GO:0035249)4.25195297
30glutamate receptor signaling pathway (GO:0007215)4.24765920
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21238406
32positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.16262673
33synaptic vesicle docking involved in exocytosis (GO:0016081)4.15851244
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15187684
35regulation of synapse structural plasticity (GO:0051823)4.06269211
36neurotransmitter secretion (GO:0007269)4.04087123
37regulation of synaptic vesicle transport (GO:1902803)4.03193178
38presynaptic membrane organization (GO:0097090)4.02452238
39auditory behavior (GO:0031223)4.01268838
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.99399131
41L-amino acid import (GO:0043092)3.96969474
42positive regulation of membrane potential (GO:0045838)3.92785134
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92289150
44neurotransmitter uptake (GO:0001504)3.89762073
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86805607
46long-term memory (GO:0007616)3.86597459
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.85494278
48response to auditory stimulus (GO:0010996)3.80734506
49neuron-neuron synaptic transmission (GO:0007270)3.80090887
50cellular potassium ion homeostasis (GO:0030007)3.79263450
51astrocyte differentiation (GO:0048708)3.78069809
52transmission of nerve impulse (GO:0019226)3.72984579
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67943339
54amino acid import (GO:0043090)3.65984156
55neuron recognition (GO:0008038)3.65933446
56proline transport (GO:0015824)3.65697135
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.65570408
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62111582
59positive regulation of dendritic spine development (GO:0060999)3.60055576
60dendrite morphogenesis (GO:0048813)3.56354008
61acidic amino acid transport (GO:0015800)3.56344344
62regulation of dendritic spine morphogenesis (GO:0061001)3.54626714
63alanine transport (GO:0032328)3.51283962
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49654885
65cellular sodium ion homeostasis (GO:0006883)3.49626435
66regulation of postsynaptic membrane potential (GO:0060078)3.49318277
67C4-dicarboxylate transport (GO:0015740)3.44716741
68pyrimidine nucleobase catabolic process (GO:0006208)3.43603049
69establishment of mitochondrion localization (GO:0051654)3.43290193
70cerebellar Purkinje cell layer development (GO:0021680)3.40222894
71startle response (GO:0001964)3.39441367
72neurotransmitter transport (GO:0006836)3.38514218
73regulation of synaptic plasticity (GO:0048167)3.37263311
74sodium ion export (GO:0071436)3.35893310
75long-term synaptic potentiation (GO:0060291)3.35072858
76prepulse inhibition (GO:0060134)3.32225847
77mechanosensory behavior (GO:0007638)3.31362310
78axonal fasciculation (GO:0007413)3.31279231
79positive regulation of neurotransmitter secretion (GO:0001956)3.29907496
80synapse assembly (GO:0007416)3.28202528
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27453002
82regulation of dendritic spine development (GO:0060998)3.26839511
83regulation of respiratory system process (GO:0044065)3.26032647
84membrane assembly (GO:0071709)3.24106996
85neuromuscular process controlling balance (GO:0050885)3.22932256
86regulation of neurotransmitter secretion (GO:0046928)3.22202785
87positive regulation of synapse assembly (GO:0051965)3.20853948
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20651586
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18140991
90oligodendrocyte differentiation (GO:0048709)3.17421958
91regulation of neurotransmitter levels (GO:0001505)3.12459612
92L-glutamate transport (GO:0015813)3.11988940
93regulation of vesicle fusion (GO:0031338)3.10429000
94gamma-aminobutyric acid signaling pathway (GO:0007214)3.09281217
95positive regulation of neurotransmitter transport (GO:0051590)3.09273306
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.07845377
97cell communication by electrical coupling (GO:0010644)3.06757211
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04813218
99positive regulation of synapse maturation (GO:0090129)3.04579430
100learning (GO:0007612)3.03151280
101regulation of neurotransmitter transport (GO:0051588)3.02413955
102membrane depolarization (GO:0051899)3.00421075
103regulation of synaptic transmission, GABAergic (GO:0032228)2.99229119
104astrocyte development (GO:0014002)2.99127012
105regulation of respiratory gaseous exchange (GO:0043576)2.98026753
106regulation of voltage-gated calcium channel activity (GO:1901385)2.97041974
107positive regulation of synaptic transmission (GO:0050806)2.96717113
108membrane hyperpolarization (GO:0060081)2.96546087
109synaptic vesicle endocytosis (GO:0048488)2.94899709
110central nervous system projection neuron axonogenesis (GO:0021952)2.92505786
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92167216
112dendritic spine organization (GO:0097061)2.92080158
113response to histamine (GO:0034776)2.91344260
114neuronal ion channel clustering (GO:0045161)2.89121652
115activation of protein kinase A activity (GO:0034199)2.88351281
116synapse organization (GO:0050808)2.88350394
117neuromuscular process (GO:0050905)2.88100889
118cell migration in hindbrain (GO:0021535)2.87876254
119glycine transport (GO:0015816)2.87748119
120* regulation of synaptic transmission (GO:0050804)2.87071913
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86414235
122response to dietary excess (GO:0002021)2.86255451
123innervation (GO:0060384)2.85159155
124righting reflex (GO:0060013)2.85041978
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82582536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98842732
2GBX2_23144817_ChIP-Seq_PC3_Human3.60764471
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.33237421
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23072255
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12768691
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86826622
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86826622
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.85986365
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85713493
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.79471999
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73175137
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64074718
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.59019950
14AR_21572438_ChIP-Seq_LNCaP_Human2.57140040
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55944232
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50529784
17REST_21632747_ChIP-Seq_MESCs_Mouse2.49706012
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.36916447
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.34277896
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33732982
21DROSHA_22980978_ChIP-Seq_HELA_Human2.32738753
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.09849148
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.09027579
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02887045
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00123979
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95808074
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.95523092
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87034855
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85152235
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83686489
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79239583
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76475590
33TAF15_26573619_Chip-Seq_HEK293_Human1.74320123
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71922237
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70863307
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.64234535
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61753444
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.58913511
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56012345
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53196548
41SMAD4_21799915_ChIP-Seq_A2780_Human1.52962283
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51231980
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50649729
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49780495
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49362078
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.47638874
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.44508473
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41004075
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40985608
50* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40983985
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.39955874
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.39681163
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39177838
54P300_19829295_ChIP-Seq_ESCs_Human1.37129050
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33003854
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28852927
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.27292403
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25485720
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.25074299
60ZNF274_21170338_ChIP-Seq_K562_Hela1.23798942
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.22423983
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21755160
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19943933
64AR_25329375_ChIP-Seq_VCAP_Human1.19077495
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.18880019
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15771375
67STAT3_23295773_ChIP-Seq_U87_Human1.14306048
68RNF2_27304074_Chip-Seq_NSC_Mouse1.14301940
69IGF1R_20145208_ChIP-Seq_DFB_Human1.13268478
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13100349
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12384124
72AR_19668381_ChIP-Seq_PC3_Human1.10908623
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10604482
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09379809
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08853136
76CTCF_27219007_Chip-Seq_Bcells_Human1.08747868
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06407860
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05819913
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04542122
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03561705
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03444317
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03160137
83TCF4_23295773_ChIP-Seq_U87_Human1.02895439
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02606108
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02229533
86RUNX2_22187159_ChIP-Seq_PCA_Human1.01684875
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01229871
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99240684
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.97865989
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.97498947
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96664137
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.96219535
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95619452
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94982988
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93788528
96TP53_18474530_ChIP-ChIP_U2OS_Human0.93599787
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.93525426
98TP53_16413492_ChIP-PET_HCT116_Human0.92343262
99RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92266820
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91885614
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.91175563
102AHR_22903824_ChIP-Seq_MCF-7_Human0.91098484
103POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90668251
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90108697
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89941882
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.89424033
107ER_23166858_ChIP-Seq_MCF-7_Human0.89009611
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.88989110
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88960257
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88960257
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88251456
112FUS_26573619_Chip-Seq_HEK293_Human0.88249538
113BCAT_22108803_ChIP-Seq_LS180_Human0.87550998
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.87500644
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87231369
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.86115156
117RXR_22108803_ChIP-Seq_LS180_Human0.84899379
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84877343
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84820256
120KDM2B_26808549_Chip-Seq_K562_Human0.83923681
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83416523
122SOX9_26525672_Chip-Seq_HEART_Mouse0.81679940
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81461517
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81107842
125SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80420620
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79209047
127* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78529622
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77681015
129NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.77611256
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77109784
131LXR_22292898_ChIP-Seq_THP-1_Human0.75279093
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75023759
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.74709058
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74422293
135* KLF4_19829295_ChIP-Seq_ESCs_Human0.74269576
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73571515
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.73442594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90452842
2MP0003880_abnormal_central_pattern4.95937532
3* MP0003635_abnormal_synaptic_transmissio3.96922196
4MP0004270_analgesia3.58238486
5MP0005423_abnormal_somatic_nervous3.40210745
6MP0009745_abnormal_behavioral_response3.33054790
7MP0002063_abnormal_learning/memory/cond3.13188033
8MP0001486_abnormal_startle_reflex3.00056505
9MP0002064_seizures2.99905608
10MP0001968_abnormal_touch/_nociception2.98899816
11MP0009046_muscle_twitch2.79243640
12MP0002572_abnormal_emotion/affect_behav2.78025497
13MP0002734_abnormal_mechanical_nocicepti2.52985861
14MP0002272_abnormal_nervous_system2.39588125
15MP0002736_abnormal_nociception_after2.38653188
16MP0002822_catalepsy2.35719427
17MP0001440_abnormal_grooming_behavior2.12275875
18MP0000778_abnormal_nervous_system2.09874656
19MP0003329_amyloid_beta_deposits2.09384457
20MP0004858_abnormal_nervous_system2.03810578
21MP0005646_abnormal_pituitary_gland2.00181339
22MP0002733_abnormal_thermal_nociception1.97921259
23MP0002067_abnormal_sensory_capabilities1.97147145
24MP0001501_abnormal_sleep_pattern1.95173466
25MP0008569_lethality_at_weaning1.90710249
26MP0001970_abnormal_pain_threshold1.89372134
27MP0009780_abnormal_chondrocyte_physiolo1.89074806
28* MP0002557_abnormal_social/conspecific_i1.88236848
29MP0004885_abnormal_endolymph1.84060936
30MP0002735_abnormal_chemical_nociception1.75389752
31MP0002653_abnormal_ependyma_morphology1.74922987
32MP0002184_abnormal_innervation1.72198895
33MP0001984_abnormal_olfaction1.65272039
34MP0005645_abnormal_hypothalamus_physiol1.61924141
35MP0001188_hyperpigmentation1.54147179
36MP0001502_abnormal_circadian_rhythm1.53628370
37MP0000955_abnormal_spinal_cord1.52119332
38MP0003879_abnormal_hair_cell1.50575989
39MP0002882_abnormal_neuron_morphology1.49570483
40MP0004811_abnormal_neuron_physiology1.47722735
41MP0005386_behavior/neurological_phenoty1.47039742
42MP0004924_abnormal_behavior1.47039742
43MP0006276_abnormal_autonomic_nervous1.46103001
44MP0003690_abnormal_glial_cell1.41761815
45MP0004142_abnormal_muscle_tone1.39724226
46MP0002909_abnormal_adrenal_gland1.36485464
47MP0002066_abnormal_motor_capabilities/c1.35983267
48MP0005551_abnormal_eye_electrophysiolog1.31756028
49MP0003633_abnormal_nervous_system1.26531481
50MP0005409_darkened_coat_color1.25667265
51MP0002638_abnormal_pupillary_reflex1.23228268
52MP0004742_abnormal_vestibular_system1.22273900
53MP0003634_abnormal_glial_cell1.20435985
54MP0001905_abnormal_dopamine_level1.18929012
55MP0002152_abnormal_brain_morphology1.18792560
56MP0003136_yellow_coat_color1.18183190
57MP0000631_abnormal_neuroendocrine_gland1.14787604
58MP0003283_abnormal_digestive_organ1.14608385
59MP0003631_nervous_system_phenotype1.11218576
60MP0001529_abnormal_vocalization1.07900346
61MP0002249_abnormal_larynx_morphology1.04904767
62MP0000920_abnormal_myelination1.04850021
63MP0001963_abnormal_hearing_physiology1.02497285
64MP0000579_abnormal_nail_morphology1.02418275
65MP0000566_synostosis0.99220676
66MP0002229_neurodegeneration0.97203839
67MP0001177_atelectasis0.94774533
68MP0002752_abnormal_somatic_nervous0.94153453
69MP0003632_abnormal_nervous_system0.93378678
70MP0006292_abnormal_olfactory_placode0.91319046
71MP0003075_altered_response_to0.90368801
72MP0001485_abnormal_pinna_reflex0.89165982
73MP0002090_abnormal_vision0.88046896
74MP0003787_abnormal_imprinting0.87541577
75MP0000604_amyloidosis0.86777760
76MP0006072_abnormal_retinal_apoptosis0.85773354
77MP0000026_abnormal_inner_ear0.85244120
78MP0002069_abnormal_eating/drinking_beha0.84002020
79MP0008872_abnormal_physiological_respon0.83845570
80MP0001346_abnormal_lacrimal_gland0.83000599
81MP0001986_abnormal_taste_sensitivity0.82641997
82MP0000569_abnormal_digit_pigmentation0.78782813
83MP0003938_abnormal_ear_development0.78227249
84MP0005253_abnormal_eye_physiology0.74455713
85MP0008874_decreased_physiological_sensi0.74198924
86MP0000751_myopathy0.72860002
87MP0003137_abnormal_impulse_conducting0.72697938
88MP0005171_absent_coat_pigmentation0.72544196
89MP0005394_taste/olfaction_phenotype0.72524057
90MP0005499_abnormal_olfactory_system0.72524057
91MP0003183_abnormal_peptide_metabolism0.71287382
92MP0005535_abnormal_body_temperature0.70384332
93MP0004145_abnormal_muscle_electrophysio0.69456898
94MP0004085_abnormal_heartbeat0.66829660
95MP0000534_abnormal_ureter_morphology0.66024146
96MP0003121_genomic_imprinting0.65600198
97MP0003861_abnormal_nervous_system0.65330524
98MP0002102_abnormal_ear_morphology0.65095826
99MP0001664_abnormal_digestion0.64885946
100MP0003123_paternal_imprinting0.64566066
101MP0005248_abnormal_Harderian_gland0.64466510
102MP0005167_abnormal_blood-brain_barrier0.64160743
103MP0004130_abnormal_muscle_cell0.63165354
104MP0001943_abnormal_respiration0.63088171
105MP0004215_abnormal_myocardial_fiber0.62594706
106MP0010770_preweaning_lethality0.61207691
107MP0002082_postnatal_lethality0.61207691
108MP0010768_mortality/aging0.59108424
109MP0001299_abnormal_eye_distance/0.58563627
110MP0005379_endocrine/exocrine_gland_phen0.56756764
111MP0002081_perinatal_lethality0.55978554
112MP0009379_abnormal_foot_pigmentation0.55407557
113MP0005187_abnormal_penis_morphology0.54946693
114MP0003122_maternal_imprinting0.53346947
115MP0003172_abnormal_lysosome_physiology0.52769001
116MP0002876_abnormal_thyroid_physiology0.51396305
117MP0005623_abnormal_meninges_morphology0.51058948
118MP0010769_abnormal_survival0.49863611

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.21452975
2Myokymia (HP:0002411)6.35770748
3Focal seizures (HP:0007359)5.27189267
4Epileptic encephalopathy (HP:0200134)4.89524438
5Visual hallucinations (HP:0002367)4.86758992
6Progressive cerebellar ataxia (HP:0002073)4.07419854
7Febrile seizures (HP:0002373)3.95523725
8Atonic seizures (HP:0010819)3.73393363
9Hemiparesis (HP:0001269)3.71626650
10Megalencephaly (HP:0001355)3.66159341
11Broad-based gait (HP:0002136)3.59073806
12Generalized tonic-clonic seizures (HP:0002069)3.58732627
13Supranuclear gaze palsy (HP:0000605)3.50360966
14Absence seizures (HP:0002121)3.47210547
15Action tremor (HP:0002345)3.46433886
16Abnormality of binocular vision (HP:0011514)3.44962913
17Diplopia (HP:0000651)3.44962913
18Aplasia involving bones of the upper limbs (HP:0009823)3.36952576
19Aplasia of the phalanges of the hand (HP:0009802)3.36952576
20Aplasia involving bones of the extremities (HP:0009825)3.36952576
21Ankle clonus (HP:0011448)3.36451323
22Neurofibrillary tangles (HP:0002185)3.35431312
23Hyperventilation (HP:0002883)3.28995226
24Dialeptic seizures (HP:0011146)3.27220294
25Dysdiadochokinesis (HP:0002075)3.22082041
26Gaze-evoked nystagmus (HP:0000640)3.13164495
27Hemiplegia (HP:0002301)3.11411657
28Increased circulating renin level (HP:0000848)3.10895089
29Impaired vibration sensation in the lower limbs (HP:0002166)3.10123674
30Abnormal eating behavior (HP:0100738)3.06763298
31Mutism (HP:0002300)3.06361736
32Anxiety (HP:0000739)3.00129341
33Depression (HP:0000716)2.97097311
34Poor eye contact (HP:0000817)2.88919669
35Truncal ataxia (HP:0002078)2.88124194
36Urinary bladder sphincter dysfunction (HP:0002839)2.87268667
37Papilledema (HP:0001085)2.78526647
38Abnormality of the diencephalon (HP:0010662)2.77564462
39Excessive salivation (HP:0003781)2.77276597
40Drooling (HP:0002307)2.77276597
41Dysmetria (HP:0001310)2.76999904
42Cerebral inclusion bodies (HP:0100314)2.74302539
43Morphological abnormality of the inner ear (HP:0011390)2.73003059
44Genetic anticipation (HP:0003743)2.62113941
45Obstructive sleep apnea (HP:0002870)2.56391367
46Postural instability (HP:0002172)2.52666417
47Polyphagia (HP:0002591)2.52349285
48Turricephaly (HP:0000262)2.51943532
49Stereotypic behavior (HP:0000733)2.51512061
50Urinary urgency (HP:0000012)2.50046262
51Overriding aorta (HP:0002623)2.49697826
52Oligodactyly (hands) (HP:0001180)2.49217339
53Status epilepticus (HP:0002133)2.47286543
54Impaired social interactions (HP:0000735)2.46992965
55Abnormal social behavior (HP:0012433)2.46992965
56Progressive inability to walk (HP:0002505)2.41736521
57Absent speech (HP:0001344)2.38849614
58Elfin facies (HP:0004428)2.38787258
59Amblyopia (HP:0000646)2.37330781
60Hyperacusis (HP:0010780)2.33121505
61Spastic gait (HP:0002064)2.32995456
62Scanning speech (HP:0002168)2.30320121
63Torticollis (HP:0000473)2.28146332
64Impaired smooth pursuit (HP:0007772)2.26631129
65Impaired vibratory sensation (HP:0002495)2.26513512
66Agitation (HP:0000713)2.24562987
67Limb dystonia (HP:0002451)2.23527172
68Abnormality of cochlea (HP:0000375)2.22873671
69Intention tremor (HP:0002080)2.20553682
70Spastic tetraparesis (HP:0001285)2.20360927
71Fetal akinesia sequence (HP:0001989)2.18789994
72Lower limb muscle weakness (HP:0007340)2.18782389
73Bradykinesia (HP:0002067)2.16455391
74Anomalous pulmonary venous return (HP:0010772)2.12041144
75Generalized myoclonic seizures (HP:0002123)2.11729188
76Epileptiform EEG discharges (HP:0011182)2.08622102
77Tetraplegia (HP:0002445)2.08559811
78Focal dystonia (HP:0004373)2.07824608
79Bowel incontinence (HP:0002607)2.07152055
80EEG with generalized epileptiform discharges (HP:0011198)2.04722743
81Blue irides (HP:0000635)2.01873759
82Inability to walk (HP:0002540)1.99653468
83Bronchomalacia (HP:0002780)1.99053362
84Truncus arteriosus (HP:0001660)1.97631646
85Narrow nasal bridge (HP:0000446)1.97262586
86Absent/shortened dynein arms (HP:0200106)1.97250988
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.97250988
88Hypsarrhythmia (HP:0002521)1.96366886
89Abnormality of the corticospinal tract (HP:0002492)1.96125788
90Peripheral hypomyelination (HP:0007182)1.95212675
91Clumsiness (HP:0002312)1.95141693
92Abnormality of ocular smooth pursuit (HP:0000617)1.94666370
93Gait imbalance (HP:0002141)1.94264819
94Hypoplasia of the corpus callosum (HP:0002079)1.93758310
95Abnormality of salivation (HP:0100755)1.92644980
96Renovascular hypertension (HP:0100817)1.91726810
97Oligodactyly (HP:0012165)1.89389323
98Humeroradial synostosis (HP:0003041)1.88529314
99Synostosis involving the elbow (HP:0003938)1.88529314
100Gait ataxia (HP:0002066)1.87064170
101Annular pancreas (HP:0001734)1.86857162
102Split foot (HP:0001839)1.86427630
103Abnormal large intestine physiology (HP:0012700)1.86328247
104Sleep apnea (HP:0010535)1.86325661
105Septo-optic dysplasia (HP:0100842)1.84093915
106Retinal dysplasia (HP:0007973)1.83056511
107Abnormality of the 4th metacarpal (HP:0010012)1.81168908
108Morphological abnormality of the pyramidal tract (HP:0002062)1.81114742
109Diminished motivation (HP:0000745)1.80972160
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80255098
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.80255098
112Pointed chin (HP:0000307)1.78444720
113Craniofacial dystonia (HP:0012179)1.78215704
114Abnormality of the pulmonary veins (HP:0011718)1.78182243
115Metabolic alkalosis (HP:0200114)1.77247564
116Specific learning disability (HP:0001328)1.76795912
117Akinesia (HP:0002304)1.75638945
118Rigidity (HP:0002063)1.74889778
119Cerebral hypomyelination (HP:0006808)1.74580416
120Renal duplication (HP:0000075)1.73225168
121Neuronal loss in central nervous system (HP:0002529)1.71687436
122Incomplete penetrance (HP:0003829)1.70006501
123Insomnia (HP:0100785)1.68615221
124Termporal pattern (HP:0011008)1.67864798
125Insidious onset (HP:0003587)1.67864798
126Lower limb amyotrophy (HP:0007210)1.67562193
127Abnormal ciliary motility (HP:0012262)1.66909299
128Clonus (HP:0002169)1.66381109
129Psychosis (HP:0000709)1.64825530
130Apathy (HP:0000741)1.64776893
131Bradycardia (HP:0001662)1.64592621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.67515057
2NTRK33.94414944
3MARK13.86000948
4TNIK3.65920206
5CASK3.48269387
6MAP3K92.93805919
7NTRK22.81530068
8MAP2K72.47132784
9MAP3K42.37510159
10MINK12.33925060
11DAPK22.12914479
12PRKD32.04272891
13PHKG11.99175026
14PHKG21.99175026
15MAPK131.92490910
16PAK61.89537998
17MUSK1.68909239
18MAP3K121.66667663
19FES1.55673950
20CAMKK11.53977089
21PRPF4B1.49950947
22CDK51.46659415
23NTRK11.45450360
24STK381.44052451
25MAP2K41.43962076
26SIK21.31413740
27LMTK21.28725162
28CDK191.28509550
29MAPK151.27565946
30KSR21.24824178
31KSR11.18309576
32RIPK41.17961395
33PRKCG1.15159623
34UHMK11.12433208
35GRK51.09263125
36PLK21.08103923
37CAMK11.02699861
38DAPK11.00404475
39PNCK0.99272091
40CAMK2A0.97183111
41TYRO30.97133887
42CAMKK20.93604327
43STK110.91520662
44MAP3K130.89779699
45ROCK20.86564018
46DYRK1A0.85725405
47NEK60.83142533
48CDK150.80960009
49CDK180.80341241
50CSNK1G30.78463226
51SGK2230.77852180
52SGK4940.77852180
53CSNK1A1L0.76252665
54FGR0.75639528
55CDK140.75306246
56TAOK10.74130565
57MARK20.72446144
58CSNK1G20.72151504
59CDK11A0.71834163
60MKNK20.70716321
61PRKCH0.70343930
62PAK30.69605158
63OXSR10.69587743
64FGFR20.67976872
65MAP3K20.66981712
66CAMK2D0.66351575
67PINK10.66298731
68BRSK10.65811972
69CAMK2B0.65459906
70SGK10.65295041
71TNK20.65058585
72PRKCE0.64748821
73LATS20.64426976
74SGK20.63966869
75PKN10.61734836
76PRKD20.61306747
77CSNK1G10.58276146
78MAPK120.58133610
79BMPR20.54745517
80ERBB20.50987952
81IRAK20.50961974
82PRKCZ0.50690667
83ALK0.50143557
84RPS6KA30.50092981
85CAMK1G0.49014758
86RET0.48020372
87CAMK1D0.47892122
88FYN0.45330948
89SGK30.44411534
90CSNK1D0.44146260
91CDC42BPA0.43605641
92ICK0.42198375
93MAPKAPK50.41126755
94ARAF0.41056492
95CDK30.40184644
96PDPK10.40083448
97MAP3K10.39755450
98PDGFRA0.38811457
99BMX0.38492551
100CAMK40.38465982
101EPHB20.37378741
102PDGFRB0.37054467
103RAF10.36080616
104MAP3K70.34933776
105ROCK10.34758702
106MAPK100.34745786
107DYRK20.33981320
108PDK10.33769292
109CAMK2G0.33746145
110PRKG10.33321230
111ADRBK10.32959293
112CCNB10.32332230
113PRKACA0.31899130
114PRKCA0.31877291
115PTK2B0.31626707
116ERBB30.31543306
117RIPK10.31461837
118PRKDC0.31093763
119CSNK1E0.29960944
120EPHA30.28143219
121CSNK1A10.27705719
122MAP2K10.26987683
123RPS6KB10.26885537
124GSK3B0.26434220

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92882352
2Glutamatergic synapse_Homo sapiens_hsa047242.85753919
3GABAergic synapse_Homo sapiens_hsa047272.84391863
4Olfactory transduction_Homo sapiens_hsa047402.82345893
5Synaptic vesicle cycle_Homo sapiens_hsa047212.79150433
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67007216
7Morphine addiction_Homo sapiens_hsa050322.64153878
8Circadian entrainment_Homo sapiens_hsa047132.61942073
9Amphetamine addiction_Homo sapiens_hsa050312.32379344
10Long-term potentiation_Homo sapiens_hsa047202.31716861
11Salivary secretion_Homo sapiens_hsa049702.21661009
12Insulin secretion_Homo sapiens_hsa049112.01916132
13Dopaminergic synapse_Homo sapiens_hsa047282.01864219
14Gastric acid secretion_Homo sapiens_hsa049711.98432325
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94375177
16Cocaine addiction_Homo sapiens_hsa050301.90941249
17Cholinergic synapse_Homo sapiens_hsa047251.86562120
18Nitrogen metabolism_Homo sapiens_hsa009101.86049166
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80890183
20Long-term depression_Homo sapiens_hsa047301.72642437
21Taste transduction_Homo sapiens_hsa047421.71800506
22Serotonergic synapse_Homo sapiens_hsa047261.70254898
23Calcium signaling pathway_Homo sapiens_hsa040201.67932302
24Renin secretion_Homo sapiens_hsa049241.66752159
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58578376
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51536833
27Gap junction_Homo sapiens_hsa045401.41966960
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41330854
29GnRH signaling pathway_Homo sapiens_hsa049121.36313477
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35162464
31Axon guidance_Homo sapiens_hsa043601.34205630
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33898874
33Vitamin B6 metabolism_Homo sapiens_hsa007501.32218466
34cAMP signaling pathway_Homo sapiens_hsa040241.31732449
35Phototransduction_Homo sapiens_hsa047441.29900471
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26142544
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20877400
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19991620
39Melanogenesis_Homo sapiens_hsa049161.19487204
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11558052
41Dorso-ventral axis formation_Homo sapiens_hsa043201.09982845
42Glioma_Homo sapiens_hsa052141.09511057
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07957925
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02730645
45Fatty acid biosynthesis_Homo sapiens_hsa000611.01046954
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99932193
47Estrogen signaling pathway_Homo sapiens_hsa049150.99540135
48ErbB signaling pathway_Homo sapiens_hsa040120.98663723
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.95825614
50Cardiac muscle contraction_Homo sapiens_hsa042600.94093955
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91851082
52Collecting duct acid secretion_Homo sapiens_hsa049660.90077669
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86285230
54Type II diabetes mellitus_Homo sapiens_hsa049300.85009626
55Notch signaling pathway_Homo sapiens_hsa043300.83247326
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82537600
57Pancreatic secretion_Homo sapiens_hsa049720.80932872
58Hippo signaling pathway_Homo sapiens_hsa043900.80719797
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78389642
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78045339
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77694681
62Thyroid hormone synthesis_Homo sapiens_hsa049180.70890777
63Choline metabolism in cancer_Homo sapiens_hsa052310.69706835
64Dilated cardiomyopathy_Homo sapiens_hsa054140.68563701
65MAPK signaling pathway_Homo sapiens_hsa040100.66438099
66Ras signaling pathway_Homo sapiens_hsa040140.65041688
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64681143
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64076596
69Wnt signaling pathway_Homo sapiens_hsa043100.63205620
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.62681907
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62586149
72Oocyte meiosis_Homo sapiens_hsa041140.59679293
73Circadian rhythm_Homo sapiens_hsa047100.59654719
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58977553
75Alcoholism_Homo sapiens_hsa050340.58833659
76Rap1 signaling pathway_Homo sapiens_hsa040150.58641438
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56488232
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53396960
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52524342
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51707019
81Bile secretion_Homo sapiens_hsa049760.50193247
82Vibrio cholerae infection_Homo sapiens_hsa051100.49443215
83Type I diabetes mellitus_Homo sapiens_hsa049400.48526880
84Colorectal cancer_Homo sapiens_hsa052100.45628151
85beta-Alanine metabolism_Homo sapiens_hsa004100.45328021
86Glucagon signaling pathway_Homo sapiens_hsa049220.44958797
87African trypanosomiasis_Homo sapiens_hsa051430.43815906
88Ovarian steroidogenesis_Homo sapiens_hsa049130.43602944
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.43008015
90Prion diseases_Homo sapiens_hsa050200.40785996
91AMPK signaling pathway_Homo sapiens_hsa041520.40411968
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39267650
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39119360
94Renal cell carcinoma_Homo sapiens_hsa052110.38810262
95Tight junction_Homo sapiens_hsa045300.35712739
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35347757
97Endometrial cancer_Homo sapiens_hsa052130.35309600
98VEGF signaling pathway_Homo sapiens_hsa043700.34236708
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33398971
100Arginine and proline metabolism_Homo sapiens_hsa003300.33139321
101Hedgehog signaling pathway_Homo sapiens_hsa043400.32449461
102mTOR signaling pathway_Homo sapiens_hsa041500.31740961
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31617860
104Histidine metabolism_Homo sapiens_hsa003400.31316297
105Basal cell carcinoma_Homo sapiens_hsa052170.31071979
106Chemokine signaling pathway_Homo sapiens_hsa040620.30647447
107Endocytosis_Homo sapiens_hsa041440.30123357
108Fatty acid metabolism_Homo sapiens_hsa012120.29499405
109PPAR signaling pathway_Homo sapiens_hsa033200.28639099
110Melanoma_Homo sapiens_hsa052180.27993068
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27203630
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.27088158
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24448518
114Alzheimers disease_Homo sapiens_hsa050100.24411417
115Inositol phosphate metabolism_Homo sapiens_hsa005620.24297607
116Insulin signaling pathway_Homo sapiens_hsa049100.23213285

Most similar genes based on co-expression Upload to Enrichr

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