CSPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.26443498
2cilium movement (GO:0003341)5.74029884
3epithelial cilium movement (GO:0003351)5.35293390
4intraciliary transport (GO:0042073)5.27650550
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.09564326
6regulation of cilium movement (GO:0003352)5.00258135
7startle response (GO:0001964)5.00090137
8cilium or flagellum-dependent cell motility (GO:0001539)4.92743092
9ventricular system development (GO:0021591)4.70722031
10presynaptic membrane assembly (GO:0097105)4.66342708
11axoneme assembly (GO:0035082)4.45098685
12sperm motility (GO:0030317)4.29319598
13motile cilium assembly (GO:0044458)4.27557567
14regulation of centriole replication (GO:0046599)4.23581847
15nonmotile primary cilium assembly (GO:0035058)4.11406134
16presynaptic membrane organization (GO:0097090)3.97924037
17photoreceptor cell differentiation (GO:0046530)3.89814683
18eye photoreceptor cell differentiation (GO:0001754)3.89814683
19cilium assembly (GO:0042384)3.89219356
20single strand break repair (GO:0000012)3.84146872
21cilium organization (GO:0044782)3.82097412
22centriole assembly (GO:0098534)3.72143265
23regulation of centrosome duplication (GO:0010824)3.72040773
24microtubule polymerization or depolymerization (GO:0031109)3.70687203
25limb bud formation (GO:0060174)3.57811444
26establishment of protein localization to Golgi (GO:0072600)3.49276271
27replication fork processing (GO:0031297)3.47573984
28microtubule bundle formation (GO:0001578)3.41019889
29interkinetic nuclear migration (GO:0022027)3.39727002
30ganglion development (GO:0061548)3.34655282
31neuron cell-cell adhesion (GO:0007158)3.33654411
32regulation of centrosome cycle (GO:0046605)3.33233959
33retina layer formation (GO:0010842)3.29047819
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.22022980
35protein localization to microtubule cytoskeleton (GO:0072698)3.21830591
36centriole replication (GO:0007099)3.20586083
37protein targeting to Golgi (GO:0000042)3.20013695
38cell differentiation involved in kidney development (GO:0061005)3.17187325
39mRNA splice site selection (GO:0006376)3.16026664
40intra-S DNA damage checkpoint (GO:0031573)3.16004757
41postsynaptic membrane organization (GO:0001941)3.15313873
42regulation of meiosis I (GO:0060631)3.15224582
43protein polyglutamylation (GO:0018095)3.14262689
44microtubule-based movement (GO:0007018)3.11446435
45regulation of timing of cell differentiation (GO:0048505)3.10582058
46piRNA metabolic process (GO:0034587)3.10090111
47mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08105098
48mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08105098
49mitotic sister chromatid cohesion (GO:0007064)3.06020831
50photoreceptor cell maintenance (GO:0045494)3.04452702
51regulation of microtubule-based movement (GO:0060632)3.04247776
52neural tube formation (GO:0001841)3.01319010
53retrograde transport, vesicle recycling within Golgi (GO:0000301)3.00242146
54spinal cord motor neuron differentiation (GO:0021522)3.00150338
55spermatid development (GO:0007286)2.98502898
56cellular component assembly involved in morphogenesis (GO:0010927)2.97680869
57nuclear pore complex assembly (GO:0051292)2.96699392
58DNA methylation involved in gamete generation (GO:0043046)2.95601859
59protein K6-linked ubiquitination (GO:0085020)2.95516839
60male meiosis I (GO:0007141)2.94886348
61somite rostral/caudal axis specification (GO:0032525)2.94842905
62response to pheromone (GO:0019236)2.93862387
63dentate gyrus development (GO:0021542)2.92612650
64left/right pattern formation (GO:0060972)2.91460656
65retinal rod cell development (GO:0046548)2.89468302
66sister chromatid cohesion (GO:0007062)2.87993755
67sympathetic nervous system development (GO:0048485)2.85266625
68limb development (GO:0060173)2.85099751
69appendage development (GO:0048736)2.85099751
70somite development (GO:0061053)2.84427147
71resolution of meiotic recombination intermediates (GO:0000712)2.83106577
72regulation of development, heterochronic (GO:0040034)2.81258643
73poly(A)+ mRNA export from nucleus (GO:0016973)2.81236306
74negative regulation of DNA-dependent DNA replication (GO:2000104)2.80358919
75synaptic transmission, glutamatergic (GO:0035249)2.79362753
76kidney morphogenesis (GO:0060993)2.79245398
77rRNA catabolic process (GO:0016075)2.78974300
78negative regulation of axon guidance (GO:1902668)2.78596937
79microtubule anchoring (GO:0034453)2.77746748
80synapsis (GO:0007129)2.75208275
81sperm capacitation (GO:0048240)2.74105570
82acrosome reaction (GO:0007340)2.73891726
83recombinational repair (GO:0000725)2.73809276
84prostate gland growth (GO:0060736)2.73016962
85histone exchange (GO:0043486)2.72149898
86cilium morphogenesis (GO:0060271)2.71512134
87double-strand break repair via homologous recombination (GO:0000724)2.71236177
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69877098
89positive regulation of gastrulation (GO:2000543)2.69741505
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68992213
91ionotropic glutamate receptor signaling pathway (GO:0035235)2.68179822
92protein localization to cytoskeleton (GO:0044380)2.67344556
93glomerulus development (GO:0032835)2.66980946
94multicellular organism reproduction (GO:0032504)2.66597009
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.66370717
96regulation of translation, ncRNA-mediated (GO:0045974)2.66370717
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66370717
98cerebral cortex radially oriented cell migration (GO:0021799)2.65983226
99embryonic digit morphogenesis (GO:0042733)2.65320469
100eye photoreceptor cell development (GO:0042462)2.64742499
101microtubule depolymerization (GO:0007019)2.63715374
102protein localization to Golgi apparatus (GO:0034067)2.62540148
103hindbrain development (GO:0030902)2.57618360
104keratinocyte development (GO:0003334)2.56924467
105cell differentiation involved in metanephros development (GO:0072202)2.54621209
106nucleotide transmembrane transport (GO:1901679)2.53501566
107protein localization to cilium (GO:0061512)2.52248892
108detection of calcium ion (GO:0005513)2.52158095
109DNA double-strand break processing (GO:0000729)2.52050864
110retinal cone cell development (GO:0046549)2.51897854
111centrosome organization (GO:0051297)2.51523308
112positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.51310884
113microtubule organizing center organization (GO:0031023)2.51104827
114regulation of pigment cell differentiation (GO:0050932)2.50756517
115glutamate receptor signaling pathway (GO:0007215)2.50034603
116histone H3-K4 trimethylation (GO:0080182)2.49859998
117regulation of telomere maintenance (GO:0032204)2.49605294
118photoreceptor cell development (GO:0042461)2.48492013
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48421080
120regulation of mitotic spindle checkpoint (GO:1903504)2.48421080
121meiotic cell cycle (GO:0051321)2.47941276
122male meiosis (GO:0007140)2.47816177
123epithelial cell differentiation involved in kidney development (GO:0035850)2.47248779
124reciprocal DNA recombination (GO:0035825)2.46772046
125reciprocal meiotic recombination (GO:0007131)2.46772046
126cornea development in camera-type eye (GO:0061303)2.46562931
127mesonephros development (GO:0001823)2.44194946
128left/right axis specification (GO:0070986)2.43999632
129organelle assembly (GO:0070925)2.43874810
130cranial nerve development (GO:0021545)2.43459422
131chromatin remodeling at centromere (GO:0031055)2.42992564
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42710445
133regulation of DNA endoreduplication (GO:0032875)2.42651188
134mesenchymal cell differentiation (GO:0048762)2.42518801
135determination of left/right symmetry (GO:0007368)2.42004731
136olfactory bulb development (GO:0021772)2.41532412
137pore complex assembly (GO:0046931)2.39991932
138genitalia morphogenesis (GO:0035112)2.39686212
139sperm-egg recognition (GO:0035036)2.38096156
140mechanosensory behavior (GO:0007638)2.37901838
141pyrimidine dimer repair (GO:0006290)2.37505385
142kidney mesenchyme development (GO:0072074)2.37478438
143neuron-neuron synaptic transmission (GO:0007270)2.36894136
144ER overload response (GO:0006983)2.35887165
145reflex (GO:0060004)2.35777049
146cell projection assembly (GO:0030031)2.35249871
147meiotic chromosome segregation (GO:0045132)2.35055467
148glycerophospholipid catabolic process (GO:0046475)2.34868610
149kinetochore organization (GO:0051383)2.34797106
150synaptic vesicle endocytosis (GO:0048488)2.34520420
151ncRNA catabolic process (GO:0034661)2.34486512
152regulation of smoothened signaling pathway (GO:0008589)2.34316425
153negative regulation of keratinocyte proliferation (GO:0010839)2.34094765
154peptidyl-lysine dimethylation (GO:0018027)2.33998681
155L-fucose catabolic process (GO:0042355)2.33442142
156fucose catabolic process (GO:0019317)2.33442142
157L-fucose metabolic process (GO:0042354)2.33442142
158inner ear receptor stereocilium organization (GO:0060122)2.32758469
159cyclic nucleotide catabolic process (GO:0009214)2.32744728
160positive regulation of action potential (GO:0045760)2.32534467
161righting reflex (GO:0060013)2.32478525
162developmental pigmentation (GO:0048066)2.32430985
163protein K11-linked deubiquitination (GO:0035871)2.32368019
164determination of bilateral symmetry (GO:0009855)2.32348206
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32341507
166head development (GO:0060322)2.30946352
167CENP-A containing nucleosome assembly (GO:0034080)2.30551173
168smoothened signaling pathway (GO:0007224)2.30412097
169cell differentiation in spinal cord (GO:0021515)2.29440905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human3.91320552
2EZH2_22144423_ChIP-Seq_EOC_Human3.60913585
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79239881
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59729136
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57613140
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42123205
7ZNF274_21170338_ChIP-Seq_K562_Hela2.42017004
8TAF15_26573619_Chip-Seq_HEK293_Human2.40552491
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29593561
10* FLI1_27457419_Chip-Seq_LIVER_Mouse2.22935073
11* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19075313
12FUS_26573619_Chip-Seq_HEK293_Human2.18862057
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17118995
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09084882
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04065323
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00750583
17* P300_19829295_ChIP-Seq_ESCs_Human2.00649972
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98719081
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87947787
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87886446
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87511669
22IGF1R_20145208_ChIP-Seq_DFB_Human1.87411879
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86649922
24EWS_26573619_Chip-Seq_HEK293_Human1.85810139
25* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83845772
26SMAD4_21799915_ChIP-Seq_A2780_Human1.83438194
27* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83386945
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.80772533
29CBP_20019798_ChIP-Seq_JUKART_Human1.80772533
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.80580866
31* NANOG_18555785_Chip-Seq_ESCs_Mouse1.79153648
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78594307
33IRF1_19129219_ChIP-ChIP_H3396_Human1.78445480
34RNF2_27304074_Chip-Seq_NSC_Mouse1.78208072
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73159269
36* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72150633
37ER_23166858_ChIP-Seq_MCF-7_Human1.69681238
38* NFE2_27457419_Chip-Seq_LIVER_Mouse1.69020413
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.68767946
40* E2F1_18555785_Chip-Seq_ESCs_Mouse1.67674361
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.67239841
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64490884
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63280004
44STAT3_23295773_ChIP-Seq_U87_Human1.62986707
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59390484
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59390484
47* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58737455
48* P53_22387025_ChIP-Seq_ESCs_Mouse1.57835971
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57433775
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56261808
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.54802936
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53799747
53* EZH2_27294783_Chip-Seq_NPCs_Mouse1.53255523
54* CMYC_18555785_Chip-Seq_ESCs_Mouse1.52687618
55* TCF4_23295773_ChIP-Seq_U87_Human1.52299463
56* STAT3_18555785_Chip-Seq_ESCs_Mouse1.50603923
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49645935
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48598027
59* P300_18555785_Chip-Seq_ESCs_Mouse1.47364891
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46832819
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46828058
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45369294
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44854989
64BCAT_22108803_ChIP-Seq_LS180_Human1.42956697
65* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42419124
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42150499
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39180156
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.39064422
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.35867187
70* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35425391
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.35209236
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.35183616
73* SOX2_18555785_Chip-Seq_ESCs_Mouse1.35006876
74RUNX2_22187159_ChIP-Seq_PCA_Human1.34740256
75* OCT4_18555785_Chip-Seq_ESCs_Mouse1.34660381
76* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34113914
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33762491
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33242675
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32736805
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32339171
81TCF4_22108803_ChIP-Seq_LS180_Human1.31955709
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31842491
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28753818
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28592651
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.27891263
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26523238
87* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26175277
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25106637
89* ZFX_18555785_Chip-Seq_ESCs_Mouse1.24062145
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.23995493
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.23813677
92TP53_16413492_ChIP-PET_HCT116_Human1.23727765
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22489703
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22205178
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21137285
96AR_21572438_ChIP-Seq_LNCaP_Human1.20805734
97* AR_25329375_ChIP-Seq_VCAP_Human1.20558353
98VDR_22108803_ChIP-Seq_LS180_Human1.19702803
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19502935
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19481158
101* KLF4_18555785_Chip-Seq_ESCs_Mouse1.18790006
102REST_21632747_ChIP-Seq_MESCs_Mouse1.18715464
103GABP_17652178_ChIP-ChIP_JURKAT_Human1.18406174
104ETV1_20927104_ChIP-Seq_GIST48_Human1.17692456
105* ELK1_19687146_ChIP-ChIP_HELA_Human1.17179996
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16817052
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16494059
108* CTCF_18555785_Chip-Seq_ESCs_Mouse1.16382197
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.16129069
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16033253
111* SOX2_19829295_ChIP-Seq_ESCs_Human1.15852358
112* NANOG_19829295_ChIP-Seq_ESCs_Human1.15852358
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14858538
114* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14764462
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14579401
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14372847
117TBL1_22424771_ChIP-Seq_293T_Human1.13220321
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12805419
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12797471
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12494240
121E2F7_22180533_ChIP-Seq_HELA_Human1.12175830
122* PU1_27457419_Chip-Seq_LIVER_Mouse1.11804145
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11218875
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10983254
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10591291
126* SOX9_26525672_Chip-Seq_HEART_Mouse1.10372342
127* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09780909
128NFYB_21822215_ChIP-Seq_K562_Human1.09078122
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07638057
130TP53_22573176_ChIP-Seq_HFKS_Human1.07370843
131PHF8_20622853_ChIP-Seq_HELA_Human1.06971523
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.06026075
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05070829
134CDX2_22108803_ChIP-Seq_LS180_Human1.04826143
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03990268
136MYC_18940864_ChIP-ChIP_HL60_Human1.03923685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.02656040
2MP0003787_abnormal_imprinting3.50091616
3MP0002653_abnormal_ependyma_morphology3.28828778
4MP0000566_synostosis2.83142808
5MP0001188_hyperpigmentation2.81156172
6MP0010386_abnormal_urinary_bladder2.77555056
7MP0006292_abnormal_olfactory_placode2.68295003
8MP0005646_abnormal_pituitary_gland2.55977207
9MP0005409_darkened_coat_color2.32748068
10MP0005171_absent_coat_pigmentation2.30002261
11MP0003183_abnormal_peptide_metabolism2.29783860
12MP0000569_abnormal_digit_pigmentation2.26390839
13MP0003121_genomic_imprinting2.10245642
14MP0005645_abnormal_hypothalamus_physiol2.04357468
15MP0002938_white_spotting1.99353759
16MP0010094_abnormal_chromosome_stability1.89020644
17MP0001984_abnormal_olfaction1.88933860
18MP0001929_abnormal_gametogenesis1.87294622
19MP0003880_abnormal_central_pattern1.80868666
20MP0000383_abnormal_hair_follicle1.80735202
21MP0000015_abnormal_ear_pigmentation1.75028890
22MP0008058_abnormal_DNA_repair1.72961267
23MP0001293_anophthalmia1.72732856
24MP0000427_abnormal_hair_cycle1.72077696
25MP0005410_abnormal_fertilization1.71035653
26MP0002876_abnormal_thyroid_physiology1.68376344
27MP0005379_endocrine/exocrine_gland_phen1.67569938
28MP0006072_abnormal_retinal_apoptosis1.66075366
29MP0000631_abnormal_neuroendocrine_gland1.65556865
30MP0002282_abnormal_trachea_morphology1.64359645
31MP0008057_abnormal_DNA_replication1.61714775
32MP0009780_abnormal_chondrocyte_physiolo1.60938382
33MP0005551_abnormal_eye_electrophysiolog1.59372341
34MP0003122_maternal_imprinting1.58143085
35MP0002102_abnormal_ear_morphology1.56904917
36MP0004133_heterotaxia1.56405771
37MP0002210_abnormal_sex_determination1.56334364
38MP0001986_abnormal_taste_sensitivity1.54234886
39MP0001486_abnormal_startle_reflex1.53610298
40MP0005248_abnormal_Harderian_gland1.50760533
41MP0005377_hearing/vestibular/ear_phenot1.47776247
42MP0003878_abnormal_ear_physiology1.47776247
43MP0004270_analgesia1.47686465
44MP0002095_abnormal_skin_pigmentation1.47671101
45MP0002638_abnormal_pupillary_reflex1.47490465
46MP0002233_abnormal_nose_morphology1.47371167
47MP0003937_abnormal_limbs/digits/tail_de1.46803141
48MP0000778_abnormal_nervous_system1.43008216
49MP0003718_maternal_effect1.42988961
50MP0002572_abnormal_emotion/affect_behav1.37935331
51MP0009046_muscle_twitch1.37125857
52MP0009745_abnormal_behavioral_response1.36601520
53MP0005253_abnormal_eye_physiology1.35935943
54MP0006276_abnormal_autonomic_nervous1.34413291
55MP0002557_abnormal_social/conspecific_i1.30631489
56MP0002067_abnormal_sensory_capabilities1.30212274
57MP0002160_abnormal_reproductive_system1.27912369
58MP0005367_renal/urinary_system_phenotyp1.27431573
59MP0000516_abnormal_urinary_system1.27431573
60MP0000653_abnormal_sex_gland1.27025075
61MP0005174_abnormal_tail_pigmentation1.26875065
62MP0001145_abnormal_male_reproductive1.26787854
63MP0008877_abnormal_DNA_methylation1.26619624
64MP0008875_abnormal_xenobiotic_pharmacok1.26496181
65MP0002734_abnormal_mechanical_nocicepti1.24944526
66MP0000049_abnormal_middle_ear1.23629736
67MP0001177_atelectasis1.22984786
68MP0003890_abnormal_embryonic-extraembry1.22216067
69MP0010678_abnormal_skin_adnexa1.20057000
70MP0009697_abnormal_copulation1.19656694
71MP0005389_reproductive_system_phenotype1.17473754
72MP0002751_abnormal_autonomic_nervous1.15410694
73MP0003950_abnormal_plasma_membrane1.15009421
74MP0002735_abnormal_chemical_nociception1.14342329
75MP0000026_abnormal_inner_ear1.13251831
76MP0001905_abnormal_dopamine_level1.12299620
77MP0003755_abnormal_palate_morphology1.11125945
78MP0002249_abnormal_larynx_morphology1.10446220
79MP0003941_abnormal_skin_development1.10063006
80MP0002272_abnormal_nervous_system1.10036052
81MP0008789_abnormal_olfactory_epithelium1.09174366
82MP0001299_abnormal_eye_distance/1.08954001
83MP0003693_abnormal_embryo_hatching1.08923442
84MP0004134_abnormal_chest_morphology1.08238745
85MP0001502_abnormal_circadian_rhythm1.07238381
86MP0000538_abnormal_urinary_bladder1.07198729
87MP0001485_abnormal_pinna_reflex1.07114571
88MP0000462_abnormal_digestive_system1.07001924
89MP0005623_abnormal_meninges_morphology1.06469667
90MP0002177_abnormal_outer_ear1.05278721
91MP0001963_abnormal_hearing_physiology1.05119565
92MP0002163_abnormal_gland_morphology1.04061390
93MP0003635_abnormal_synaptic_transmissio1.03686571
94MP0002063_abnormal_learning/memory/cond1.03303941
95MP0002084_abnormal_developmental_patter1.02906636
96MP0008995_early_reproductive_senescence1.02582420
97MP0005499_abnormal_olfactory_system1.02342153
98MP0005394_taste/olfaction_phenotype1.02342153
99MP0001919_abnormal_reproductive_system1.02340381
100MP0002736_abnormal_nociception_after1.01114544
101MP0001286_abnormal_eye_development1.00445358
102MP0005391_vision/eye_phenotype0.99703007
103MP0000372_irregular_coat_pigmentation0.98734288
104MP0003868_abnormal_feces_composition0.98450508
105MP0002277_abnormal_respiratory_mucosa0.97675502
106MP0002064_seizures0.97593702
107MP0009250_abnormal_appendicular_skeleto0.97066014
108MP0003861_abnormal_nervous_system0.96587456
109MP0003119_abnormal_digestive_system0.96554007
110MP0005423_abnormal_somatic_nervous0.96493460
111MP0001968_abnormal_touch/_nociception0.96011731
112MP0004742_abnormal_vestibular_system0.95361496
113MP0000955_abnormal_spinal_cord0.94847915
114MP0005195_abnormal_posterior_eye0.93373784
115MP0002161_abnormal_fertility/fecundity0.93113025
116MP0004142_abnormal_muscle_tone0.91883814
117MP0004957_abnormal_blastocyst_morpholog0.90770312
118MP0000647_abnormal_sebaceous_gland0.90754474
119MP0004043_abnormal_pH_regulation0.90506053
120MP0003698_abnormal_male_reproductive0.90301527
121MP0010030_abnormal_orbit_morphology0.90269866
122MP0001529_abnormal_vocalization0.89900651
123MP0000613_abnormal_salivary_gland0.88561028
124MP0002116_abnormal_craniofacial_bone0.88081021
125MP0002693_abnormal_pancreas_physiology0.87577795
126MP0002127_abnormal_cardiovascular_syste0.87344733
127MP0002234_abnormal_pharynx_morphology0.86528915
128MP0003077_abnormal_cell_cycle0.86145409
129MP0002184_abnormal_innervation0.85450118
130MP0005386_behavior/neurological_phenoty0.85445370
131MP0004924_abnormal_behavior0.85445370
132MP0009703_decreased_birth_body0.83853306
133MP0001186_pigmentation_phenotype0.83800676
134MP0001664_abnormal_digestion0.82179366
135MP0003938_abnormal_ear_development0.82038309
136MP0002752_abnormal_somatic_nervous0.81580631
137MP0001501_abnormal_sleep_pattern0.81363654
138MP0004885_abnormal_endolymph0.79321570
139MP0003935_abnormal_craniofacial_develop0.77914798
140MP0004215_abnormal_myocardial_fiber0.77763142
141MP0003943_abnormal_hepatobiliary_system0.75737181
142MP0000432_abnormal_head_morphology0.75675635

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.73333346
2Abnormal ciliary motility (HP:0012262)5.44701691
3Abnormal respiratory motile cilium physiology (HP:0012261)5.41357994
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.58665496
5Absent/shortened dynein arms (HP:0200106)4.58665496
6Abnormal respiratory epithelium morphology (HP:0012253)4.28291954
7Abnormal respiratory motile cilium morphology (HP:0005938)4.28291954
8Rhinitis (HP:0012384)4.01186709
9True hermaphroditism (HP:0010459)3.59551286
10Volvulus (HP:0002580)3.48222535
11Pancreatic fibrosis (HP:0100732)3.40470605
12Tubulointerstitial nephritis (HP:0001970)3.28496016
13Medial flaring of the eyebrow (HP:0010747)3.24693274
14Tubular atrophy (HP:0000092)3.18505840
15Chronic hepatic failure (HP:0100626)3.15451373
16Gait imbalance (HP:0002141)3.07474877
17Nephrogenic diabetes insipidus (HP:0009806)3.06481489
18Congenital primary aphakia (HP:0007707)3.06084945
19Chronic bronchitis (HP:0004469)2.98142661
20Blue irides (HP:0000635)2.89850488
21Stomach cancer (HP:0012126)2.89067703
22Protruding tongue (HP:0010808)2.72022638
23Pancreatic cysts (HP:0001737)2.71774516
24Abnormality of midbrain morphology (HP:0002418)2.64664236
25Molar tooth sign on MRI (HP:0002419)2.64664236
26Nasal polyposis (HP:0100582)2.61104734
27Sclerocornea (HP:0000647)2.60969711
28Neoplasm of the adrenal cortex (HP:0100641)2.56384571
29Genital tract atresia (HP:0001827)2.52661614
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51718084
31Poor coordination (HP:0002370)2.51675304
32Hypochromic microcytic anemia (HP:0004840)2.50376530
33Vaginal atresia (HP:0000148)2.49960101
34Median cleft lip (HP:0000161)2.49795269
35Hepatoblastoma (HP:0002884)2.48854418
36Nephronophthisis (HP:0000090)2.46172685
37Abnormality of the renal medulla (HP:0100957)2.45710416
38Fibular hypoplasia (HP:0003038)2.44357989
39Abnormal biliary tract physiology (HP:0012439)2.43928219
40Bile duct proliferation (HP:0001408)2.43928219
41Papillary thyroid carcinoma (HP:0002895)2.43850017
42Bronchitis (HP:0012387)2.42488615
43Bronchiectasis (HP:0002110)2.40442009
44Hypothermia (HP:0002045)2.38391870
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.33917309
46Anencephaly (HP:0002323)2.33205935
47Preaxial hand polydactyly (HP:0001177)2.32660585
48Chromsome breakage (HP:0040012)2.31351240
49Infertility (HP:0000789)2.30149691
50Polyuria (HP:0000103)2.28379673
51Recurrent sinusitis (HP:0011108)2.26695011
52Febrile seizures (HP:0002373)2.23359062
53Cystic liver disease (HP:0006706)2.23231574
54Polydipsia (HP:0001959)2.23105184
55Abnormal drinking behavior (HP:0030082)2.23105184
56Supernumerary spleens (HP:0009799)2.20487511
57Postaxial foot polydactyly (HP:0001830)2.19720864
58Osteomalacia (HP:0002749)2.19365542
59Short tibia (HP:0005736)2.17588508
60White forelock (HP:0002211)2.16083934
61Intellectual disability, moderate (HP:0002342)2.13753853
62Abnormality of the labia minora (HP:0012880)2.11624679
63Intestinal atresia (HP:0011100)2.10594632
64Abnormal hair whorl (HP:0010721)2.05960232
65Ectopic anus (HP:0004397)2.05286213
66Male pseudohermaphroditism (HP:0000037)2.04547867
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.03016153
68Abnormality of incisor morphology (HP:0011063)2.02910041
69Atelectasis (HP:0100750)2.01542749
70Congenital hepatic fibrosis (HP:0002612)1.98950360
71* Oculomotor apraxia (HP:0000657)1.97225725
72Aplasia/Hypoplasia of the lens (HP:0008063)1.96950653
73Patchy hypopigmentation of hair (HP:0011365)1.94991148
74Nephroblastoma (Wilms tumor) (HP:0002667)1.94789149
75Absent eyebrow (HP:0002223)1.94233463
76Tubulointerstitial abnormality (HP:0001969)1.94048966
77Epileptic encephalopathy (HP:0200134)1.94013093
78Morphological abnormality of the middle ear (HP:0008609)1.92304868
79Bifid tongue (HP:0010297)1.90513966
80Renal dysplasia (HP:0000110)1.89712885
81High anterior hairline (HP:0009890)1.89407362
82Sloping forehead (HP:0000340)1.88057581
83Oligodactyly (hands) (HP:0001180)1.86472157
84Decreased circulating renin level (HP:0003351)1.85683038
85Hypoplasia of the fovea (HP:0007750)1.84855939
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.84855939
87Curly hair (HP:0002212)1.84640350
88* Occipital encephalocele (HP:0002085)1.83942371
89Hyperventilation (HP:0002883)1.83880974
90Abnormal urine output (HP:0012590)1.83723625
91Myelomeningocele (HP:0002475)1.81424753
92Embryonal renal neoplasm (HP:0011794)1.81274844
93* Aganglionic megacolon (HP:0002251)1.80536129
94Postaxial hand polydactyly (HP:0001162)1.80518584
95Bony spicule pigmentary retinopathy (HP:0007737)1.79663340
96Abnormality of the renal collecting system (HP:0004742)1.79632438
97Lip pit (HP:0100267)1.79213476
98* Narrow forehead (HP:0000341)1.79206088
99Fair hair (HP:0002286)1.78002335
100Wide intermamillary distance (HP:0006610)1.77637320
101Abnormality of the nasal mucosa (HP:0000433)1.77111484
102Furrowed tongue (HP:0000221)1.75631258
103Abnormality of the fovea (HP:0000493)1.75309566
104Oligohydramnios (HP:0001562)1.75233251
105Decreased central vision (HP:0007663)1.73590556
106Aplasia/Hypoplasia of the fibula (HP:0006492)1.73197357
107Cystic hygroma (HP:0000476)1.73065049
108Abnormality of the nasal septum (HP:0000419)1.72973499
109Abnormality of the renal cortex (HP:0011035)1.72196277
110Embryonal neoplasm (HP:0002898)1.71461822
111Adrenal hypoplasia (HP:0000835)1.71089453
112Abnormal pancreas size (HP:0012094)1.70444294
113Gastrointestinal atresia (HP:0002589)1.70151210
114Rib fusion (HP:0000902)1.69645004
115* Highly arched eyebrow (HP:0002553)1.69234111
116Abnormality of renal excretion (HP:0011036)1.68422109
117Renal hypoplasia (HP:0000089)1.68148549
118Renal cortical cysts (HP:0000803)1.67611262
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67093508
120Male infertility (HP:0003251)1.66694161
121Attenuation of retinal blood vessels (HP:0007843)1.65308682
122Stage 5 chronic kidney disease (HP:0003774)1.64529882
123Optic nerve coloboma (HP:0000588)1.64236795
124Optic nerve hypoplasia (HP:0000609)1.62816330
125Hypoplastic labia majora (HP:0000059)1.62510020
126Enlarged kidneys (HP:0000105)1.62461691
127Medulloblastoma (HP:0002885)1.61826355
128Abnormal rod and cone electroretinograms (HP:0008323)1.60114189
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.60094759
130Abnormality of the frontal sinuses (HP:0002687)1.59760157
131Multicystic kidney dysplasia (HP:0000003)1.59174907
132Congenital sensorineural hearing impairment (HP:0008527)1.59119054
133Recurrent otitis media (HP:0000403)1.58646787
134Abnormality of chromosome stability (HP:0003220)1.57336430
135* Prominent nasal bridge (HP:0000426)1.55729705
136Colon cancer (HP:0003003)1.55069899
137Septo-optic dysplasia (HP:0100842)1.54712443
138Ectopic kidney (HP:0000086)1.50401418
139Type 2 muscle fiber atrophy (HP:0003554)1.48680862
140Astigmatism (HP:0000483)1.47671912
141Progressive cerebellar ataxia (HP:0002073)1.45576444
142Gaze-evoked nystagmus (HP:0000640)1.45432824
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.45153081
144Dandy-Walker malformation (HP:0001305)1.45048642
145Abnormality of the labia majora (HP:0012881)1.44615618
146Birth length less than 3rd percentile (HP:0003561)1.44357481
147Labial hypoplasia (HP:0000066)1.43980679
148Abnormality of the ischium (HP:0003174)1.43361763
149Chronic sinusitis (HP:0011109)1.42975530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.30317798
2TNIK3.61776546
3MKNK23.54077889
4MST43.39823319
5AKT32.94477517
6INSRR2.53628719
7ZAK2.47503891
8BRD42.22568286
9BRSK22.20890282
10MKNK12.20182743
11ACVR1B2.12961043
12NUAK12.12580050
13NTRK32.07870339
14WEE12.04829859
15MAP4K21.95114306
16CDC71.95053411
17IRAK11.86536569
18FRK1.84398208
19IRAK31.80700862
20SRPK11.80287463
21MAPK151.78743171
22MAPK131.74009558
23ICK1.73505621
24IRAK21.72181331
25ERBB31.65224947
26YES11.63573419
27STK161.63026246
28MAP2K71.61332595
29NEK61.61046486
30SGK21.45974414
31CDK31.41203082
32PTK2B1.41016877
33PRPF4B1.40710760
34PLK21.38764544
35BMPR1B1.37289270
36CSNK1A1L1.35847278
37LATS11.31212356
38IRAK41.28475112
39PNCK1.25064424
40BMPR21.17949975
41TTK1.16139887
42ADRBK21.15217354
43PINK11.13919134
44TRIM281.07022194
45TSSK61.04251300
46TAF11.03190586
47WNK31.02444802
48GRK71.02427621
49CDC42BPA1.02108995
50PLK11.01878835
51PLK40.94217723
52SGK2230.93009097
53SGK4940.93009097
54CAMK1G0.92053508
55BCR0.91063225
56GRK10.89137960
57WNK10.88771837
58CSNK1G10.87535158
59CSNK1G30.86872697
60TLK10.84296142
61MET0.83966376
62PLK30.83658849
63CSNK1G20.78597911
64CDK80.77513832
65VRK10.75883019
66STK38L0.75770721
67PIK3CA0.74666015
68PRKCE0.72526995
69STK390.71894091
70SGK30.69766999
71PAK30.69520235
72MAP3K40.67907414
73DYRK1A0.67753087
74BRAF0.67440946
75EIF2AK30.67351725
76CHEK10.66758159
77CCNB10.65111856
78WNK40.63573569
79NEK20.63254491
80SGK10.62892089
81RPS6KB10.62848365
82DYRK30.61772206
83OXSR10.61410879
84FGFR20.60723393
85BRSK10.60716011
86MAP2K40.59923996
87MUSK0.59894978
88PASK0.59869713
89MAPK70.59820424
90TAOK30.59026605
91EIF2AK20.58576193
92CSNK1E0.58113182
93MAP3K140.58055871
94CAMK2B0.57720915
95ATM0.54951418
96NME10.54934731
97PKN10.53407315
98PDK20.52662055
99PBK0.52568596
100SIK30.52007761
101TEC0.50999475
102EPHA40.50346573
103EIF2AK10.49073574
104PRKCG0.48871536
105PRKG10.47899094
106CDK120.47543298
107CSNK1A10.47012235
108MAP3K120.46898195
109PRKCI0.46884181
110MINK10.45911281
111FGFR10.45132218
112MARK10.44670742
113UHMK10.44520295
114NTRK20.44096800
115PRKDC0.44005614
116TXK0.43187165
117CDK70.42185509
118CAMK2D0.40125470
119TGFBR10.39411565
120CAMK2A0.39410534
121GSK3B0.39172018
122CDK20.38604503
123DYRK20.38560809
124STK30.38235682
125AURKB0.38142991
126MAPK140.37849820
127ATR0.36708051
128MELK0.36469888
129FGR0.36285880
130CHEK20.36123750
131PRKACB0.35816134
132GRK50.35074606
133ERBB40.34712508
134CDK10.34031739
135ADRBK10.33550397
136STK240.32889046
137PRKACA0.32539778

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.36353390
2Nicotine addiction_Homo sapiens_hsa050333.33201626
3Fanconi anemia pathway_Homo sapiens_hsa034602.80544806
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.69594684
5Phototransduction_Homo sapiens_hsa047442.44559025
6Taste transduction_Homo sapiens_hsa047422.20313759
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06289444
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02373798
9Propanoate metabolism_Homo sapiens_hsa006401.98343257
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96886838
11One carbon pool by folate_Homo sapiens_hsa006701.91813756
12Non-homologous end-joining_Homo sapiens_hsa034501.90063414
13Caffeine metabolism_Homo sapiens_hsa002321.88373178
14Homologous recombination_Homo sapiens_hsa034401.80930054
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75326071
16Insulin secretion_Homo sapiens_hsa049111.75208680
17Butanoate metabolism_Homo sapiens_hsa006501.72042679
18Serotonergic synapse_Homo sapiens_hsa047261.68679344
19Glutamatergic synapse_Homo sapiens_hsa047241.66011486
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65398601
21RNA transport_Homo sapiens_hsa030131.64273627
22Amphetamine addiction_Homo sapiens_hsa050311.63145797
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61438635
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59751932
25Morphine addiction_Homo sapiens_hsa050321.55766447
26Circadian entrainment_Homo sapiens_hsa047131.54910587
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42921115
28Cocaine addiction_Homo sapiens_hsa050301.42874943
29Basal transcription factors_Homo sapiens_hsa030221.40685529
30Selenocompound metabolism_Homo sapiens_hsa004501.37044050
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36780909
32Basal cell carcinoma_Homo sapiens_hsa052171.36374701
33Circadian rhythm_Homo sapiens_hsa047101.35379585
34Dorso-ventral axis formation_Homo sapiens_hsa043201.35097986
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35060008
36Sulfur metabolism_Homo sapiens_hsa009201.34273710
37GABAergic synapse_Homo sapiens_hsa047271.33746744
38Nucleotide excision repair_Homo sapiens_hsa034201.31444152
39RNA degradation_Homo sapiens_hsa030181.30460991
40Collecting duct acid secretion_Homo sapiens_hsa049661.27450054
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26715397
42Sphingolipid metabolism_Homo sapiens_hsa006001.21731262
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19601306
44Chemical carcinogenesis_Homo sapiens_hsa052041.18744560
45Olfactory transduction_Homo sapiens_hsa047401.18675336
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16917809
47Hedgehog signaling pathway_Homo sapiens_hsa043401.14827762
48Nitrogen metabolism_Homo sapiens_hsa009101.14410265
49Mismatch repair_Homo sapiens_hsa034301.11051824
50Fatty acid biosynthesis_Homo sapiens_hsa000611.10373012
51Long-term potentiation_Homo sapiens_hsa047201.08136782
52Calcium signaling pathway_Homo sapiens_hsa040201.07821167
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07236481
54Alcoholism_Homo sapiens_hsa050341.06740190
55Wnt signaling pathway_Homo sapiens_hsa043101.00214265
56Vibrio cholerae infection_Homo sapiens_hsa051101.00085828
57beta-Alanine metabolism_Homo sapiens_hsa004100.97866203
58Ether lipid metabolism_Homo sapiens_hsa005650.93147275
59Endometrial cancer_Homo sapiens_hsa052130.92540770
60mRNA surveillance pathway_Homo sapiens_hsa030150.91179343
61Long-term depression_Homo sapiens_hsa047300.90158983
62Dopaminergic synapse_Homo sapiens_hsa047280.89183083
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86768945
64Synaptic vesicle cycle_Homo sapiens_hsa047210.86575448
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86511412
66Hippo signaling pathway_Homo sapiens_hsa043900.86436405
67ABC transporters_Homo sapiens_hsa020100.84815952
68Purine metabolism_Homo sapiens_hsa002300.83696994
69Axon guidance_Homo sapiens_hsa043600.83259551
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83243714
71Prostate cancer_Homo sapiens_hsa052150.83230162
72ErbB signaling pathway_Homo sapiens_hsa040120.82870904
73Retinol metabolism_Homo sapiens_hsa008300.82263253
74TGF-beta signaling pathway_Homo sapiens_hsa043500.82242178
75Oocyte meiosis_Homo sapiens_hsa041140.82186011
76Arachidonic acid metabolism_Homo sapiens_hsa005900.81652096
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81229078
78Type I diabetes mellitus_Homo sapiens_hsa049400.80647495
79Peroxisome_Homo sapiens_hsa041460.80609738
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77480660
81Base excision repair_Homo sapiens_hsa034100.76976707
82Fatty acid degradation_Homo sapiens_hsa000710.75744972
83Cholinergic synapse_Homo sapiens_hsa047250.74919340
84Parkinsons disease_Homo sapiens_hsa050120.74755132
85Autoimmune thyroid disease_Homo sapiens_hsa053200.73992574
86Tryptophan metabolism_Homo sapiens_hsa003800.71938563
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.71800765
88Salivary secretion_Homo sapiens_hsa049700.71769079
89cAMP signaling pathway_Homo sapiens_hsa040240.70983746
90RNA polymerase_Homo sapiens_hsa030200.69249816
91Type II diabetes mellitus_Homo sapiens_hsa049300.66623332
92Cardiac muscle contraction_Homo sapiens_hsa042600.65989495
93Oxidative phosphorylation_Homo sapiens_hsa001900.65984570
94Spliceosome_Homo sapiens_hsa030400.65521116
95Histidine metabolism_Homo sapiens_hsa003400.65176028
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63792019
97Renin secretion_Homo sapiens_hsa049240.62283451
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.61224542
99Melanoma_Homo sapiens_hsa052180.61022051
100Inositol phosphate metabolism_Homo sapiens_hsa005620.59897512
101Glutathione metabolism_Homo sapiens_hsa004800.58107538
102Huntingtons disease_Homo sapiens_hsa050160.57204160
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55849782
104Regulation of autophagy_Homo sapiens_hsa041400.54877217
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54609015
106Metabolic pathways_Homo sapiens_hsa011000.53037890
107Systemic lupus erythematosus_Homo sapiens_hsa053220.52981116
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52963783
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.52777409
110Ovarian steroidogenesis_Homo sapiens_hsa049130.52509046
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51863805
112p53 signaling pathway_Homo sapiens_hsa041150.51707038
113Fatty acid metabolism_Homo sapiens_hsa012120.50727790
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50486246
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50462892
116Pyrimidine metabolism_Homo sapiens_hsa002400.49426323
117Ras signaling pathway_Homo sapiens_hsa040140.49398853
118Tight junction_Homo sapiens_hsa045300.48213172
119MAPK signaling pathway_Homo sapiens_hsa040100.46377958
120DNA replication_Homo sapiens_hsa030300.46320202
121Choline metabolism in cancer_Homo sapiens_hsa052310.46254023
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45748601
123Lysine degradation_Homo sapiens_hsa003100.44993912
124Linoleic acid metabolism_Homo sapiens_hsa005910.44364762
125Rheumatoid arthritis_Homo sapiens_hsa053230.43953315
126Vitamin digestion and absorption_Homo sapiens_hsa049770.43532647
127FoxO signaling pathway_Homo sapiens_hsa040680.43232348
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42851278
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42390258
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41993316
131GnRH signaling pathway_Homo sapiens_hsa049120.41683522
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.41390675
133Alzheimers disease_Homo sapiens_hsa050100.40270166
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.40131630
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39869137
136Cell cycle_Homo sapiens_hsa041100.39839796
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37508024
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36566978
139Melanogenesis_Homo sapiens_hsa049160.35794876
140Gastric acid secretion_Homo sapiens_hsa049710.35626026
141Pathways in cancer_Homo sapiens_hsa052000.34301021
142Steroid biosynthesis_Homo sapiens_hsa001000.33071556
143Phagosome_Homo sapiens_hsa041450.30706787
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30425735

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