CSRNP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.41037768
2piRNA metabolic process (GO:0034587)4.39330635
3microtubule depolymerization (GO:0007019)4.27544397
4regulation of NFAT protein import into nucleus (GO:0051532)3.89348271
5synaptic vesicle maturation (GO:0016188)3.71695302
6pyrimidine nucleobase catabolic process (GO:0006208)3.60244340
7dendrite morphogenesis (GO:0048813)3.47209041
8axon extension (GO:0048675)3.46256821
9regulation of synapse structural plasticity (GO:0051823)3.43902937
10mitotic metaphase plate congression (GO:0007080)3.37108647
11presynaptic membrane assembly (GO:0097105)3.31779615
12protein localization to synapse (GO:0035418)3.29826206
13microtubule polymerization or depolymerization (GO:0031109)3.28640902
14vocalization behavior (GO:0071625)3.24149592
15DNA methylation involved in gamete generation (GO:0043046)3.21203960
16postsynaptic membrane organization (GO:0001941)3.16870000
17regulation of axon extension involved in axon guidance (GO:0048841)3.11993104
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10350299
19regulation of axon guidance (GO:1902667)3.03973282
20neuron projection extension (GO:1990138)3.01619034
21negative regulation of keratinocyte proliferation (GO:0010839)3.01505164
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97599876
23male meiosis (GO:0007140)2.96972741
24metaphase plate congression (GO:0051310)2.93857911
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92476873
26presynaptic membrane organization (GO:0097090)2.91550040
27synaptic vesicle docking involved in exocytosis (GO:0016081)2.90041725
28semaphorin-plexin signaling pathway (GO:0071526)2.89340320
29regulation of meiosis I (GO:0060631)2.88598608
30synaptic vesicle exocytosis (GO:0016079)2.87331846
31neuron remodeling (GO:0016322)2.85768222
32synaptic vesicle endocytosis (GO:0048488)2.84869235
33notochord development (GO:0030903)2.84663579
34regulation of synaptic vesicle exocytosis (GO:2000300)2.84170823
35neuron recognition (GO:0008038)2.83641454
36locomotory exploration behavior (GO:0035641)2.83380157
37dendritic spine morphogenesis (GO:0060997)2.81096849
38microtubule severing (GO:0051013)2.79634709
39cell migration in hindbrain (GO:0021535)2.77402431
40establishment of mitochondrion localization (GO:0051654)2.77386589
41DNA double-strand break processing (GO:0000729)2.76698619
42regulation of meiosis (GO:0040020)2.75537900
43sodium ion export (GO:0071436)2.74059822
44positive regulation of synapse maturation (GO:0090129)2.73705758
45positive regulation of meiosis (GO:0045836)2.72987230
46cerebral cortex radially oriented cell migration (GO:0021799)2.72681302
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72602152
48female gonad development (GO:0008585)2.72083410
49neuronal action potential propagation (GO:0019227)2.71180304
50stress granule assembly (GO:0034063)2.70693954
51regulation of synapse maturation (GO:0090128)2.70063170
52axonal fasciculation (GO:0007413)2.69288223
53central nervous system neuron axonogenesis (GO:0021955)2.69245897
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68112606
55glutamate secretion (GO:0014047)2.68028512
56exploration behavior (GO:0035640)2.67898082
57axon extension involved in axon guidance (GO:0048846)2.67089379
58neuron projection extension involved in neuron projection guidance (GO:1902284)2.67089379
59regulation of DNA methylation (GO:0044030)2.66893968
60regulation of synaptic vesicle transport (GO:1902803)2.64782988
61cranial nerve morphogenesis (GO:0021602)2.64535954
62lens morphogenesis in camera-type eye (GO:0002089)2.64511623
63regulation of neuronal synaptic plasticity (GO:0048168)2.64131230
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63577081
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61325937
66negative regulation of catenin import into nucleus (GO:0035414)2.61082813
67replication fork processing (GO:0031297)2.60959353
68cell communication by electrical coupling (GO:0010644)2.59915046
69central nervous system projection neuron axonogenesis (GO:0021952)2.59506560
70camera-type eye morphogenesis (GO:0048593)2.57092559
71planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56557292
72neuronal ion channel clustering (GO:0045161)2.55061778
73female gamete generation (GO:0007292)2.54411355
74negative regulation of dendrite morphogenesis (GO:0050774)2.54355176
75dendrite development (GO:0016358)2.54250340
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53961281
77protein polyglutamylation (GO:0018095)2.53556879
78positive regulation of meiotic cell cycle (GO:0051446)2.53027474
79nucleobase catabolic process (GO:0046113)2.52795628
80regulation of synapse assembly (GO:0051963)2.52146052
81hippocampus development (GO:0021766)2.51633027
82maturation of 5.8S rRNA (GO:0000460)2.51609129
83layer formation in cerebral cortex (GO:0021819)2.50977007
84apical protein localization (GO:0045176)2.50739817
85developmental cell growth (GO:0048588)2.48936051
86glutamate receptor signaling pathway (GO:0007215)2.47927608
87ganglion development (GO:0061548)2.47690594
88neuromuscular synaptic transmission (GO:0007274)2.46902136
89metanephric mesenchyme development (GO:0072075)2.46847916
90establishment of chromosome localization (GO:0051303)2.46133673
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.45620639
92snRNA transcription (GO:0009301)2.45224213
93synapse assembly (GO:0007416)2.45151763
94synaptic transmission, glutamatergic (GO:0035249)2.44994494
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43476928
96startle response (GO:0001964)2.43292481
97negative regulation of axonogenesis (GO:0050771)2.42953835
98neuron-neuron synaptic transmission (GO:0007270)2.42512040
99cellular potassium ion homeostasis (GO:0030007)2.41199940
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.41034321
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40727200
102behavioral defense response (GO:0002209)2.40587263
103behavioral fear response (GO:0001662)2.40587263
104positive regulation of axon extension (GO:0045773)2.39656726
105oocyte maturation (GO:0001556)2.39602739
106negative regulation of execution phase of apoptosis (GO:1900118)2.39091024
107neuromuscular process controlling balance (GO:0050885)2.37800463
108response to auditory stimulus (GO:0010996)2.37535552
109mitochondrion transport along microtubule (GO:0047497)2.37311420
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.37311420
111ephrin receptor signaling pathway (GO:0048013)2.36821975
112regulation of axonogenesis (GO:0050770)2.36782113
113neuron projection morphogenesis (GO:0048812)2.35997065
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.35829456
115epithelial cell differentiation involved in kidney development (GO:0035850)2.34868597
116generation of neurons (GO:0048699)2.34746993
117chaperone-mediated protein transport (GO:0072321)2.34613963
118regulation of meiotic cell cycle (GO:0051445)2.34169074
119positive regulation of axonogenesis (GO:0050772)2.33368208
120regulation of glutamate receptor signaling pathway (GO:1900449)2.32654332
121embryonic body morphogenesis (GO:0010172)2.32105017
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.31897718
123axonogenesis (GO:0007409)2.31305306
124regulation of synapse organization (GO:0050807)2.30999688
125regulation of keratinocyte proliferation (GO:0010837)2.30591833
126negative regulation of hormone metabolic process (GO:0032351)2.29800362
127negative regulation of hormone biosynthetic process (GO:0032353)2.29800362
128paraxial mesoderm development (GO:0048339)2.29766126
129neurotransmitter secretion (GO:0007269)2.29657264
130inositol phosphate catabolic process (GO:0071545)2.29193692
131gamma-aminobutyric acid signaling pathway (GO:0007214)2.28992652
132regulation of cAMP-dependent protein kinase activity (GO:2000479)2.28457614
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.28261206
134positive regulation of synapse assembly (GO:0051965)2.28169162
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.27849864
136oogenesis (GO:0048477)2.27750681
137synapse organization (GO:0050808)2.27618387
138telomere maintenance via telomerase (GO:0007004)2.27550710
139ionotropic glutamate receptor signaling pathway (GO:0035235)2.27100865
140dopaminergic neuron differentiation (GO:0071542)2.26982423
141negative regulation of neuron projection development (GO:0010977)2.26969734
142neurotransmitter-gated ion channel clustering (GO:0072578)2.26332286
143spinal cord development (GO:0021510)2.24553678
144negative regulation of neurotransmitter transport (GO:0051589)2.24084472
145negative regulation of meiosis (GO:0045835)2.23943311
146cerebellar granule cell differentiation (GO:0021707)2.23535606
147negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23163926
148auditory behavior (GO:0031223)2.22998335
149peripheral nervous system axon ensheathment (GO:0032292)2.22876874
150myelination in peripheral nervous system (GO:0022011)2.22876874
151cardiac ventricle formation (GO:0003211)2.21404624
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20992409
153histone H2A monoubiquitination (GO:0035518)2.20961269
154negative regulation of axon guidance (GO:1902668)2.20654419
155kidney mesenchyme development (GO:0072074)2.20153105
156righting reflex (GO:0060013)2.19523020
157olfactory bulb development (GO:0021772)2.18868990
158regulation of respiratory system process (GO:0044065)2.18813342
159kinetochore assembly (GO:0051382)2.18129186
160attachment of spindle microtubules to kinetochore (GO:0008608)2.18003272
161regulation of cilium movement (GO:0003352)2.17696559
162meiotic cell cycle (GO:0051321)2.17152288
163synaptonemal complex assembly (GO:0007130)2.16172981
164synaptonemal complex organization (GO:0070193)2.15885225
165transmission of nerve impulse (GO:0019226)2.15717315
166protein localization to microtubule cytoskeleton (GO:0072698)2.15486996
167DNA strand renaturation (GO:0000733)2.15411451
168glycerophospholipid catabolic process (GO:0046475)2.14926442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94907760
2GBX2_23144817_ChIP-Seq_PC3_Human3.39567946
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.45856133
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32915607
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18566304
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18066607
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14854508
8FUS_26573619_Chip-Seq_HEK293_Human2.14389341
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11564600
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08332819
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07869812
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07849726
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.05490572
14RNF2_27304074_Chip-Seq_NSC_Mouse2.05308578
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01682388
16TAF15_26573619_Chip-Seq_HEK293_Human2.01317843
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99398660
18IGF1R_20145208_ChIP-Seq_DFB_Human1.97852745
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94893505
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.94104428
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92436178
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91401616
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.90389823
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90224668
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84631856
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.83325045
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.82748850
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78870034
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75192494
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75168170
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.74341700
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72135721
33KDM2B_26808549_Chip-Seq_K562_Human1.71896494
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69537623
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65251350
36P300_19829295_ChIP-Seq_ESCs_Human1.64985253
37DROSHA_22980978_ChIP-Seq_HELA_Human1.64377114
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63051997
39REST_21632747_ChIP-Seq_MESCs_Mouse1.61864868
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61718666
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61718666
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60284194
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60284194
44VDR_22108803_ChIP-Seq_LS180_Human1.59670577
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.59552794
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.57392062
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.57220081
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.55907956
49SMAD4_21799915_ChIP-Seq_A2780_Human1.55335447
50EWS_26573619_Chip-Seq_HEK293_Human1.53996037
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53212710
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52474155
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52123397
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.50446723
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47289754
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.46840229
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.45935411
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.44181053
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.43670167
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43460463
61AR_21572438_ChIP-Seq_LNCaP_Human1.43100129
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40720358
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40321357
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.39793264
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39611843
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.38208226
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36951338
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36301563
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.35391205
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35276872
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34332566
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33809530
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33791451
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.31873052
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31027990
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30363539
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30224147
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.28790914
79STAT3_23295773_ChIP-Seq_U87_Human1.28554038
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.28470752
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26628210
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22797571
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21615831
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21334502
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20898010
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.20237236
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20130923
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19858249
89JUN_21703547_ChIP-Seq_K562_Human1.19699597
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19535447
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19487090
92TCF4_23295773_ChIP-Seq_U87_Human1.19471119
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19277806
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18553382
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18449637
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18409229
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.18112912
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17850698
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17646461
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.17611250
101ER_23166858_ChIP-Seq_MCF-7_Human1.17044051
102SOX9_26525672_Chip-Seq_HEART_Mouse1.17013373
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16963254
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16582747
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16544003
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16080978
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15755945
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15254385
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13996741
110AR_25329375_ChIP-Seq_VCAP_Human1.13639873
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12820698
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11582109
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.10935700
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.09739763
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09072059
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08595702
117* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08484789
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08329783
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07929370
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05869291
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05682190
122* RUNX2_22187159_ChIP-Seq_PCA_Human1.05374053
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.04909941
124P53_22387025_ChIP-Seq_ESCs_Mouse1.04870560
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04794574
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03948997
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03790359
128ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03609332
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.03385591
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03339899
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.03286673
132E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03230152
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.02071516
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01559941
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00471363
136CTCF_27219007_Chip-Seq_Bcells_Human0.98946734
137AR_19668381_ChIP-Seq_PC3_Human0.98838478
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96910363
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.94509359
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94342582
141AHR_22903824_ChIP-Seq_MCF-7_Human0.94010819
142TP53_18474530_ChIP-ChIP_U2OS_Human0.93943032
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93211215
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92860563
145CLOCK_20551151_ChIP-Seq_293T_Human0.92757521
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92474014
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92208224
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90789894
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.90024172
150FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90001421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.46963715
2MP0003787_abnormal_imprinting3.14225192
3MP0000566_synostosis2.82320485
4MP0004859_abnormal_synaptic_plasticity2.81354414
5MP0008877_abnormal_DNA_methylation2.68558808
6MP0004270_analgesia2.47241759
7MP0005409_darkened_coat_color2.42896984
8MP0002102_abnormal_ear_morphology2.41626827
9MP0001984_abnormal_olfaction2.20790958
10MP0000778_abnormal_nervous_system2.19897686
11MP0003635_abnormal_synaptic_transmissio2.14193142
12MP0006292_abnormal_olfactory_placode2.06743769
13MP0003121_genomic_imprinting1.93613495
14MP0005423_abnormal_somatic_nervous1.93193230
15MP0002063_abnormal_learning/memory/cond1.89269823
16MP0001188_hyperpigmentation1.87870831
17MP0005646_abnormal_pituitary_gland1.87270802
18MP0006276_abnormal_autonomic_nervous1.84488334
19MP0002734_abnormal_mechanical_nocicepti1.82525663
20MP0008789_abnormal_olfactory_epithelium1.81402149
21MP0005171_absent_coat_pigmentation1.80914496
22MP0009046_muscle_twitch1.80326736
23MP0003718_maternal_effect1.80231016
24MP0000751_myopathy1.70096093
25MP0003705_abnormal_hypodermis_morpholog1.69257972
26MP0002184_abnormal_innervation1.68013012
27MP0005499_abnormal_olfactory_system1.67008995
28MP0005394_taste/olfaction_phenotype1.67008995
29MP0002572_abnormal_emotion/affect_behav1.62688942
30MP0001968_abnormal_touch/_nociception1.59985853
31MP0001486_abnormal_startle_reflex1.57976587
32MP0002822_catalepsy1.57544963
33MP0009745_abnormal_behavioral_response1.55179619
34MP0002653_abnormal_ependyma_morphology1.51376806
35MP0001529_abnormal_vocalization1.50741209
36MP0010030_abnormal_orbit_morphology1.47875517
37MP0002064_seizures1.46072461
38MP0003315_abnormal_perineum_morphology1.46065525
39MP0003329_amyloid_beta_deposits1.45759062
40MP0002735_abnormal_chemical_nociception1.45036005
41MP0000537_abnormal_urethra_morphology1.44185622
42MP0001346_abnormal_lacrimal_gland1.43941319
43MP0002736_abnormal_nociception_after1.43672614
44MP0010094_abnormal_chromosome_stability1.42760199
45MP0009780_abnormal_chondrocyte_physiolo1.39529291
46MP0001440_abnormal_grooming_behavior1.36287632
47MP0000372_irregular_coat_pigmentation1.36095032
48MP0003136_yellow_coat_color1.35353824
49MP0002272_abnormal_nervous_system1.35166711
50MP0003123_paternal_imprinting1.34572333
51MP0003937_abnormal_limbs/digits/tail_de1.28997463
52MP0004924_abnormal_behavior1.28851941
53MP0005386_behavior/neurological_phenoty1.28851941
54MP0005248_abnormal_Harderian_gland1.28217484
55MP0000631_abnormal_neuroendocrine_gland1.27164336
56MP0002067_abnormal_sensory_capabilities1.26898729
57MP0002557_abnormal_social/conspecific_i1.25296004
58MP0000534_abnormal_ureter_morphology1.24346497
59MP0001177_atelectasis1.23591371
60MP0008438_abnormal_cutaneous_collagen1.23401942
61MP0001905_abnormal_dopamine_level1.19841367
62MP0002210_abnormal_sex_determination1.19004776
63MP0003935_abnormal_craniofacial_develop1.18927919
64MP0003861_abnormal_nervous_system1.17646394
65MP0000955_abnormal_spinal_cord1.16964413
66MP0005187_abnormal_penis_morphology1.16946577
67MP0003942_abnormal_urinary_system1.16884363
68MP0003111_abnormal_nucleus_morphology1.16646773
69MP0003755_abnormal_palate_morphology1.16078216
70MP0003122_maternal_imprinting1.15790209
71MP0003938_abnormal_ear_development1.15496365
72MP0002882_abnormal_neuron_morphology1.14551383
73MP0001929_abnormal_gametogenesis1.14206168
74MP0005503_abnormal_tendon_morphology1.13895710
75MP0000733_abnormal_muscle_development1.13550600
76MP0005257_abnormal_intraocular_pressure1.12340609
77MP0003698_abnormal_male_reproductive1.11230669
78MP0001485_abnormal_pinna_reflex1.11060813
79MP0003279_aneurysm1.09961680
80MP0004885_abnormal_endolymph1.09777379
81MP0002152_abnormal_brain_morphology1.09776347
82MP0002752_abnormal_somatic_nervous1.08886249
83MP0002249_abnormal_larynx_morphology1.08623451
84MP0004272_abnormal_basement_membrane1.07779691
85MP0009250_abnormal_appendicular_skeleto1.06019054
86MP0005623_abnormal_meninges_morphology1.05843266
87MP0003890_abnormal_embryonic-extraembry1.04579784
88MP0002160_abnormal_reproductive_system1.03726895
89MP0003115_abnormal_respiratory_system1.03131422
90MP0003091_abnormal_cell_migration1.02992821
91MP0003634_abnormal_glial_cell1.02665396
92MP0002081_perinatal_lethality1.02001818
93MP0001963_abnormal_hearing_physiology1.01175658
94MP0001970_abnormal_pain_threshold0.98535273
95MP0002909_abnormal_adrenal_gland0.98533309
96MP0008058_abnormal_DNA_repair0.97979403
97MP0004811_abnormal_neuron_physiology0.97905526
98MP0000653_abnormal_sex_gland0.97807736
99MP0000049_abnormal_middle_ear0.97501399
100MP0009384_cardiac_valve_regurgitation0.97385632
101MP0000579_abnormal_nail_morphology0.96513579
102MP0005076_abnormal_cell_differentiation0.95832170
103MP0010368_abnormal_lymphatic_system0.95633722
104MP0000026_abnormal_inner_ear0.94357204
105MP0002697_abnormal_eye_size0.94217416
106MP0001879_abnormal_lymphatic_vessel0.93930386
107MP0002163_abnormal_gland_morphology0.92982308
108MP0002751_abnormal_autonomic_nervous0.92184048
109MP0004233_abnormal_muscle_weight0.91857429
110MP0003385_abnormal_body_wall0.91821674
111MP0009053_abnormal_anal_canal0.91786560
112MP0002233_abnormal_nose_morphology0.89852579
113MP0008569_lethality_at_weaning0.89065386
114MP0004858_abnormal_nervous_system0.88858594
115MP0002638_abnormal_pupillary_reflex0.88142432
116MP0008932_abnormal_embryonic_tissue0.87027412
117MP0001145_abnormal_male_reproductive0.86939703
118MP0002733_abnormal_thermal_nociception0.86564036
119MP0004742_abnormal_vestibular_system0.85482778
120MP0003879_abnormal_hair_cell0.84889496
121MP0005645_abnormal_hypothalamus_physiol0.84512169
122MP0010386_abnormal_urinary_bladder0.84109230
123MP0002161_abnormal_fertility/fecundity0.83376114
124MP0001119_abnormal_female_reproductive0.82916229
125MP0005551_abnormal_eye_electrophysiolog0.82885859
126MP0002116_abnormal_craniofacial_bone0.82165576
127MP0002066_abnormal_motor_capabilities/c0.81457376
128MP0003646_muscle_fatigue0.80806334
129MP0000015_abnormal_ear_pigmentation0.80752257
130MP0002108_abnormal_muscle_morphology0.80509630
131MP0003077_abnormal_cell_cycle0.79247356
132MP0004133_heterotaxia0.79136925
133MP0000750_abnormal_muscle_regeneration0.79044787
134MP0008057_abnormal_DNA_replication0.78315748
135MP0001958_emphysema0.77218479
136MP0001299_abnormal_eye_distance/0.76797953
137MP0001502_abnormal_circadian_rhythm0.75994728
138MP0003119_abnormal_digestive_system0.75402278
139MP0003699_abnormal_female_reproductive0.74832112
140MP0000428_abnormal_craniofacial_morphol0.74774667
141MP0008007_abnormal_cellular_replicative0.72751718

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.87977204
2Papillary thyroid carcinoma (HP:0002895)3.46018878
3Gait imbalance (HP:0002141)3.22811548
4Focal motor seizures (HP:0011153)3.14850868
5Turricephaly (HP:0000262)3.08257464
6Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99127186
7Congenital primary aphakia (HP:0007707)2.93489509
8Thin bony cortex (HP:0002753)2.91245737
9Epileptic encephalopathy (HP:0200134)2.89652226
10Atonic seizures (HP:0010819)2.85910065
11Medial flaring of the eyebrow (HP:0010747)2.84527790
12Arterial tortuosity (HP:0005116)2.81972429
13Febrile seizures (HP:0002373)2.80148373
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79788670
15Vascular tortuosity (HP:0004948)2.77768473
16Chromsome breakage (HP:0040012)2.75674761
17Nephrogenic diabetes insipidus (HP:0009806)2.74154992
18Neurofibrillary tangles (HP:0002185)2.71605166
19Shallow orbits (HP:0000586)2.67202731
20Poor coordination (HP:0002370)2.66491327
21Action tremor (HP:0002345)2.61332191
22Genital tract atresia (HP:0001827)2.56457842
23Coronal craniosynostosis (HP:0004440)2.51225843
24Pancreatic fibrosis (HP:0100732)2.50358003
25Vaginal atresia (HP:0000148)2.49673592
26Abnormality of the lower motor neuron (HP:0002366)2.35146921
27Focal seizures (HP:0007359)2.34906364
28Abnormality of midbrain morphology (HP:0002418)2.26178935
29Molar tooth sign on MRI (HP:0002419)2.26178935
30Myokymia (HP:0002411)2.25981825
31Hyperventilation (HP:0002883)2.24965110
32Patellar aplasia (HP:0006443)2.24930748
33Progressive cerebellar ataxia (HP:0002073)2.24197758
34Thyroid carcinoma (HP:0002890)2.22671055
35Ankle clonus (HP:0011448)2.20834852
36Supernumerary spleens (HP:0009799)2.19060670
37Abnormal hair whorl (HP:0010721)2.17893180
38Akinesia (HP:0002304)2.17233576
39Fetal akinesia sequence (HP:0001989)2.16874395
40True hermaphroditism (HP:0010459)2.15121100
41Supranuclear gaze palsy (HP:0000605)2.15082904
42Adrenal hypoplasia (HP:0000835)2.14598197
43Aplasia/Hypoplasia of the patella (HP:0006498)2.13531729
44Broad-based gait (HP:0002136)2.11196172
45Ulnar bowing (HP:0003031)2.10259405
46Facial hemangioma (HP:0000329)2.09331330
47Broad metatarsal (HP:0001783)2.08266973
48Protrusio acetabuli (HP:0003179)2.07602325
49Birth length less than 3rd percentile (HP:0003561)2.07081653
50Spastic gait (HP:0002064)2.06927486
51Urinary urgency (HP:0000012)2.05369628
52Aplasia involving bones of the extremities (HP:0009825)2.03168323
53Aplasia involving bones of the upper limbs (HP:0009823)2.03168323
54Aplasia of the phalanges of the hand (HP:0009802)2.03168323
55Excessive salivation (HP:0003781)2.02908610
56Drooling (HP:0002307)2.02908610
57Overgrowth (HP:0001548)2.00724237
58Specific learning disability (HP:0001328)1.97542680
59Cerebral inclusion bodies (HP:0100314)1.96664689
60Morphological abnormality of the middle ear (HP:0008609)1.95354687
61Flat capital femoral epiphysis (HP:0003370)1.95256201
62Lower limb muscle weakness (HP:0007340)1.94459998
63Genu recurvatum (HP:0002816)1.94417078
64Capillary hemangiomas (HP:0005306)1.93554420
65Male infertility (HP:0003251)1.92617646
66Thickened helices (HP:0000391)1.91455523
67Abnormality of incisor morphology (HP:0011063)1.90896024
68Abnormality of chromosome segregation (HP:0002916)1.90846125
69Aplasia/Hypoplasia of the fovea (HP:0008060)1.90242853
70Hypoplasia of the fovea (HP:0007750)1.90242853
71Midline defect of the nose (HP:0004122)1.90163608
72Abnormality of the corticospinal tract (HP:0002492)1.90153769
73Aplasia/Hypoplasia of the lens (HP:0008063)1.90096202
74Abnormal respiratory motile cilium physiology (HP:0012261)1.89991848
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.88669562
76Absent speech (HP:0001344)1.87542882
77Choanal stenosis (HP:0000452)1.86907805
78Aplasia of the musculature (HP:0100854)1.86681031
79Short tibia (HP:0005736)1.85278963
80Breast aplasia (HP:0100783)1.84537302
81Atrophic scars (HP:0001075)1.84484668
82Cortical dysplasia (HP:0002539)1.83340266
83Bladder diverticulum (HP:0000015)1.82598312
84Shawl scrotum (HP:0000049)1.82235644
85Postaxial hand polydactyly (HP:0001162)1.81364638
86Premature rupture of membranes (HP:0001788)1.79658798
87Urinary bladder sphincter dysfunction (HP:0002839)1.79477185
88Limb dystonia (HP:0002451)1.79285723
89Heterotopia (HP:0002282)1.79059197
90Bowel diverticulosis (HP:0005222)1.78331815
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.78067979
92Preaxial hand polydactyly (HP:0001177)1.77749063
93Annular pancreas (HP:0001734)1.76956861
94Abnormality of the preputium (HP:0100587)1.76814152
95Truncal ataxia (HP:0002078)1.75215553
96Anterior segment dysgenesis (HP:0007700)1.74880320
97Wrist flexion contracture (HP:0001239)1.74421331
98Hyperacusis (HP:0010780)1.74183835
99Cerebral aneurysm (HP:0004944)1.73891537
100Buphthalmos (HP:0000557)1.73780743
101Abnormality of the fovea (HP:0000493)1.73475129
102Insomnia (HP:0100785)1.73441913
103Embryonal renal neoplasm (HP:0011794)1.72742737
104Pancreatic cysts (HP:0001737)1.72462659
105Aganglionic megacolon (HP:0002251)1.72341742
106Hypoventilation (HP:0002791)1.72157172
107Aplasia/Hypoplasia of the breasts (HP:0010311)1.72110272
108Vertebral arch anomaly (HP:0008438)1.71898851
109Absent radius (HP:0003974)1.70921775
110Myotonia (HP:0002486)1.70900826
111Absent eyebrow (HP:0002223)1.70875909
112Abnormality of the phalanges of the hallux (HP:0010057)1.68748604
113Cystic hygroma (HP:0000476)1.68473331
114Bifid tongue (HP:0010297)1.68467823
115Azoospermia (HP:0000027)1.68016722
116Genetic anticipation (HP:0003743)1.66829185
117Termporal pattern (HP:0011008)1.66455271
118Insidious onset (HP:0003587)1.66455271
119Complete atrioventricular canal defect (HP:0001674)1.66400233
120Thin ribs (HP:0000883)1.66351903
121Inability to walk (HP:0002540)1.66267117
122Nephronophthisis (HP:0000090)1.66214859
123Absent forearm bone (HP:0003953)1.66147364
124Aplasia involving forearm bones (HP:0009822)1.66147364
125Protruding tongue (HP:0010808)1.65478828
126Gaze-evoked nystagmus (HP:0000640)1.65403812
127Obsessive-compulsive behavior (HP:0000722)1.65221130
128Nephroblastoma (Wilms tumor) (HP:0002667)1.65197057
129Amblyopia (HP:0000646)1.64984596
130Generalized tonic-clonic seizures (HP:0002069)1.64471365
131Fair hair (HP:0002286)1.64448446
132Meckel diverticulum (HP:0002245)1.64275864
133Abnormality of chromosome stability (HP:0003220)1.64215898
134Absent/shortened dynein arms (HP:0200106)1.63895001
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.63895001
136Oligodactyly (hands) (HP:0001180)1.63731194
137Astigmatism (HP:0000483)1.63607091
138Abnormality of the lacrimal duct (HP:0011481)1.62647490
139Hammertoe (HP:0001765)1.62266646
140Impulsivity (HP:0100710)1.61807323
141Abnormality of dentin (HP:0010299)1.61797172
142High anterior hairline (HP:0009890)1.61195977
143Tibial bowing (HP:0002982)1.61176767
144Mitral regurgitation (HP:0001653)1.60637189
145Hepatoblastoma (HP:0002884)1.60336470
146Narrow forehead (HP:0000341)1.59925125
147Hand muscle atrophy (HP:0009130)1.59293347
148Germ cell neoplasia (HP:0100728)1.58915584
149Shoulder girdle muscle weakness (HP:0003547)1.58815736
150Impaired vibration sensation in the lower limbs (HP:0002166)1.58567000
151Decreased testicular size (HP:0008734)1.58265427
152Abnormality of salivation (HP:0100755)1.57752732
153Obstructive sleep apnea (HP:0002870)1.57379143
154Arnold-Chiari malformation (HP:0002308)1.57336371
155Abnormality of the ileum (HP:0001549)1.56706890
156Neoplasm of the heart (HP:0100544)1.56389453
157Atrioventricular canal defect (HP:0006695)1.56155184
158Amyotrophic lateral sclerosis (HP:0007354)1.55978053
159Ectopic kidney (HP:0000086)1.55722448
160Exotropia (HP:0000577)1.53723422
161Limb-girdle muscle weakness (HP:0003325)1.53623937
162Narrow nasal bridge (HP:0000446)1.52903655
163Mitral valve prolapse (HP:0001634)1.52477131
164Apathy (HP:0000741)1.52471978
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.51047905
166Hypoplasia of the brainstem (HP:0002365)1.51047905
167Short 4th metacarpal (HP:0010044)1.48189734
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.48189734
169Spinal rigidity (HP:0003306)1.48033170
170Soft skin (HP:0000977)1.47822239
171Sleep apnea (HP:0010535)1.45006058
172Upper limb amyotrophy (HP:0009129)1.43056572
173Distal upper limb amyotrophy (HP:0007149)1.43056572
174Megalencephaly (HP:0001355)1.42127638
175Chin dimple (HP:0010751)1.41834167
176Spina bifida occulta (HP:0003298)1.41798547
177Difficulty climbing stairs (HP:0003551)1.40567311
178Cutaneous finger syndactyly (HP:0010554)1.40375769
179Renovascular hypertension (HP:0100817)1.39352536
180Neonatal short-limb short stature (HP:0008921)1.39036192
181Megalocornea (HP:0000485)1.39003056
182Abnormality of the musculature of the pelvis (HP:0001469)1.38914209
183Abnormality of the hip-girdle musculature (HP:0001445)1.38914209
184Aortic dissection (HP:0002647)1.38191980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.81173173
2STK38L3.26446050
3LATS23.05590583
4LATS12.95465043
5RIPK12.93976471
6MAP2K72.72984015
7MARK12.62961505
8MAP3K42.61802708
9MAP3K62.53472697
10NTRK12.34616149
11PLK22.32835999
12BRD42.28554108
13EPHA42.11087418
14PRPF4B2.02901730
15NTRK32.00393479
16AKT31.99634387
17PDGFRA1.87300161
18MAPK131.85433423
19NTRK21.69226343
20TRIB31.68702947
21TTK1.65956669
22STK241.59589540
23KSR11.59435718
24PLK31.55234563
25PNCK1.53612931
26ICK1.50470596
27ERBB41.47085813
28SRPK11.46933935
29MAP3K91.46868009
30BRAF1.46063806
31CAMK1G1.41952353
32PLK41.41092147
33SGK21.38871001
34MUSK1.37285065
35ERBB31.33721158
36PAK61.32480656
37DDR21.31846948
38CDK121.31320894
39CHEK21.27877875
40BMPR1B1.27241523
41MKNK21.25381230
42UHMK11.25267489
43CDK81.23270436
44MINK11.22070047
45DYRK21.21594434
46BMPR21.17744790
47BCR1.17168782
48NEK61.12813637
49RPS6KA21.10287332
50SGK2231.07711620
51SGK4941.07711620
52CDC71.05760254
53MAP3K101.04867629
54MAP2K41.04038461
55MAPK151.02259177
56PTK21.01264651
57PINK10.96820787
58PRKD30.95975181
59STK30.95482011
60CDK30.95410367
61DYRK1B0.93360246
62SIK30.92830137
63PDGFRB0.91580153
64DYRK30.90100056
65TAOK10.88571159
66PLK10.85846716
67KSR20.84464696
68CCNB10.83482901
69TNIK0.81805034
70PKN20.79572833
71RET0.79161770
72WNK10.77983069
73DYRK1A0.77036898
74CSNK1G20.75564135
75RAF10.75265670
76STK380.75078597
77CAMK2A0.73191673
78PHKG20.71419242
79PHKG10.71419242
80ARAF0.71409341
81OXSR10.71384148
82TRIM280.69240333
83MAP3K120.66587431
84CAMK1D0.66127721
85ACVR1B0.66065904
86CSNK1G30.65835700
87NUAK10.65269623
88MTOR0.65086435
89TYRO30.64281402
90STK110.63920614
91PRKCG0.61264617
92SGK30.60761506
93SIK10.60679135
94MKNK10.60424658
95DMPK0.60329436
96GRK50.60091189
97MOS0.58759417
98PTK2B0.56930962
99MELK0.56912094
100CDK180.56589818
101CHEK10.56557182
102CAMKK10.56054873
103ROCK20.55192383
104CSNK1A1L0.53142605
105PRKCH0.53040737
106DAPK20.52598425
107CDK50.52119106
108CAMK10.51494556
109FGFR20.51111898
110RPS6KL10.50825428
111RPS6KC10.50825428
112CDK140.50686078
113FGR0.50612576
114CSNK1G10.49697416
115ATM0.49605635
116LIMK10.48680093
117AURKA0.48482598
118CDK150.47966045
119ROCK10.47923695
120MARK20.47747726
121PAK30.47422144
122TTN0.46580748
123EPHB10.46540742
124EPHB20.45925830
125PKN10.45509683
126SIK20.45418327
127TSSK60.45292769
128CDK10.44333349
129EPHA30.43609075
130SGK10.43440092
131NEK20.43252097
132CAMK2B0.42541387
133CDK190.41820724
134MAPK80.41628148
135PRKCZ0.40892098
136PRKAA10.39889306
137CAMK40.39096135
138PAK20.39090108
139RPS6KA60.38892337
140MAPK100.37975139
141PRKCE0.37837280
142CDK11A0.36807493
143GSK3B0.36504084
144BRSK10.34693144
145WEE10.34209137
146ZAK0.34068658
147YES10.33437985
148PDK30.32738722

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13974472
2Olfactory transduction_Homo sapiens_hsa047402.52156836
3Synaptic vesicle cycle_Homo sapiens_hsa047212.30174146
4Basal transcription factors_Homo sapiens_hsa030222.23795438
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12458603
6Fanconi anemia pathway_Homo sapiens_hsa034601.96619587
7Glutamatergic synapse_Homo sapiens_hsa047241.94588111
8Long-term potentiation_Homo sapiens_hsa047201.91700354
9Morphine addiction_Homo sapiens_hsa050321.88113214
10Amphetamine addiction_Homo sapiens_hsa050311.80785301
11Oocyte meiosis_Homo sapiens_hsa041141.79230046
12Taste transduction_Homo sapiens_hsa047421.78181923
13Circadian entrainment_Homo sapiens_hsa047131.77534283
14Serotonergic synapse_Homo sapiens_hsa047261.77272287
15Dopaminergic synapse_Homo sapiens_hsa047281.75787165
16GABAergic synapse_Homo sapiens_hsa047271.72039642
17Cell cycle_Homo sapiens_hsa041101.66220152
18Axon guidance_Homo sapiens_hsa043601.58002683
19Long-term depression_Homo sapiens_hsa047301.53839884
20RNA polymerase_Homo sapiens_hsa030201.52373947
21Cholinergic synapse_Homo sapiens_hsa047251.47467173
22Dilated cardiomyopathy_Homo sapiens_hsa054141.45693050
23Homologous recombination_Homo sapiens_hsa034401.45692960
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43406333
25Phototransduction_Homo sapiens_hsa047441.43224714
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43125702
27Collecting duct acid secretion_Homo sapiens_hsa049661.34801599
28mRNA surveillance pathway_Homo sapiens_hsa030151.34284568
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33511750
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30561438
31Dorso-ventral axis formation_Homo sapiens_hsa043201.29144644
32RNA degradation_Homo sapiens_hsa030181.26883535
33GnRH signaling pathway_Homo sapiens_hsa049121.23555195
34Cocaine addiction_Homo sapiens_hsa050301.22432353
35ErbB signaling pathway_Homo sapiens_hsa040121.22280675
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20510809
37Adherens junction_Homo sapiens_hsa045201.20420680
38Vitamin B6 metabolism_Homo sapiens_hsa007501.18972419
39Insulin secretion_Homo sapiens_hsa049111.18401397
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16949650
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.14959148
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14034264
43RNA transport_Homo sapiens_hsa030131.12930404
44Oxytocin signaling pathway_Homo sapiens_hsa049211.09728141
45Gap junction_Homo sapiens_hsa045401.09466990
46Salivary secretion_Homo sapiens_hsa049701.08901552
47Melanogenesis_Homo sapiens_hsa049161.08579620
48Colorectal cancer_Homo sapiens_hsa052101.08033040
49Circadian rhythm_Homo sapiens_hsa047101.06585599
50Endometrial cancer_Homo sapiens_hsa052131.04830913
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04242006
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03818841
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03093249
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01637202
55Notch signaling pathway_Homo sapiens_hsa043300.99951887
56Wnt signaling pathway_Homo sapiens_hsa043100.99912500
57TGF-beta signaling pathway_Homo sapiens_hsa043500.96533748
58Renin secretion_Homo sapiens_hsa049240.96448896
59Type II diabetes mellitus_Homo sapiens_hsa049300.96289641
60Focal adhesion_Homo sapiens_hsa045100.96126803
61Hippo signaling pathway_Homo sapiens_hsa043900.95956551
62ECM-receptor interaction_Homo sapiens_hsa045120.95502002
63Ras signaling pathway_Homo sapiens_hsa040140.95003087
64Ovarian steroidogenesis_Homo sapiens_hsa049130.94346497
65Renal cell carcinoma_Homo sapiens_hsa052110.94240870
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93412716
67Calcium signaling pathway_Homo sapiens_hsa040200.93344117
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93153937
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91577825
70Chronic myeloid leukemia_Homo sapiens_hsa052200.91455966
71Estrogen signaling pathway_Homo sapiens_hsa049150.90874511
72cAMP signaling pathway_Homo sapiens_hsa040240.90475469
73Choline metabolism in cancer_Homo sapiens_hsa052310.90202217
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89780290
75Glioma_Homo sapiens_hsa052140.86889461
76Melanoma_Homo sapiens_hsa052180.86469275
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86204718
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84943416
79MAPK signaling pathway_Homo sapiens_hsa040100.84811417
80Prion diseases_Homo sapiens_hsa050200.83865685
81Proteoglycans in cancer_Homo sapiens_hsa052050.83613809
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83511250
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82932814
84Hedgehog signaling pathway_Homo sapiens_hsa043400.81971569
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81947625
86Insulin signaling pathway_Homo sapiens_hsa049100.80748068
87VEGF signaling pathway_Homo sapiens_hsa043700.79120917
88Nucleotide excision repair_Homo sapiens_hsa034200.78864374
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.78510945
90Vibrio cholerae infection_Homo sapiens_hsa051100.74966715
91MicroRNAs in cancer_Homo sapiens_hsa052060.73768693
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73536229
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73010085
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71650433
95Gastric acid secretion_Homo sapiens_hsa049710.71098489
96Pathways in cancer_Homo sapiens_hsa052000.70850513
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70441443
98Basal cell carcinoma_Homo sapiens_hsa052170.70074836
99Inositol phosphate metabolism_Homo sapiens_hsa005620.69679754
100AMPK signaling pathway_Homo sapiens_hsa041520.68375400
101Ether lipid metabolism_Homo sapiens_hsa005650.68043646
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67957437
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67756560
104Amoebiasis_Homo sapiens_hsa051460.66815075
105p53 signaling pathway_Homo sapiens_hsa041150.65374070
106Steroid biosynthesis_Homo sapiens_hsa001000.64891949
107Purine metabolism_Homo sapiens_hsa002300.64575026
108Alcoholism_Homo sapiens_hsa050340.63859543
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62730348
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61888313
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61164827
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60233798
113Huntingtons disease_Homo sapiens_hsa050160.59569618
114Endocytosis_Homo sapiens_hsa041440.58927535
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58382447
116FoxO signaling pathway_Homo sapiens_hsa040680.58081369
117Prostate cancer_Homo sapiens_hsa052150.56586928
118Pancreatic cancer_Homo sapiens_hsa052120.56150947
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55959284
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.55627096
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55404278
122Thyroid cancer_Homo sapiens_hsa052160.55298078
123Thyroid hormone synthesis_Homo sapiens_hsa049180.54572884
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54193713
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52056968
126Rap1 signaling pathway_Homo sapiens_hsa040150.51948125
127Sphingolipid metabolism_Homo sapiens_hsa006000.51801742
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47351337
129Tight junction_Homo sapiens_hsa045300.46715589
130mTOR signaling pathway_Homo sapiens_hsa041500.45998935
131Prolactin signaling pathway_Homo sapiens_hsa049170.45954568
132Spliceosome_Homo sapiens_hsa030400.45846383
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.44568461
134Mismatch repair_Homo sapiens_hsa034300.43822414

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