ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of chronic inflammatory response (GO:0002676)	9.16774890
2	single fertilization (GO:0007338)	8.68385916
3	indole-containing compound catabolic process (GO:0042436)	8.62482086
4	indolalkylamine catabolic process (GO:0046218)	8.62482086
5	tryptophan catabolic process (GO:0006569)	8.62482086
6	heterotypic cell-cell adhesion (GO:0034113)	8.60082594
7	positive regulation of type 2 immune response (GO:0002830)	7.53736237
8	negative regulation of interleukin-10 production (GO:0032693)	7.42453049
9	tryptophan metabolic process (GO:0006568)	7.41376760
10	aromatic amino acid family catabolic process (GO:0009074)	5.90710368
11	fertilization (GO:0009566)	5.72877836
12	amine catabolic process (GO:0009310)	5.54598779
13	cellular biogenic amine catabolic process (GO:0042402)	5.54598779
14	indolalkylamine metabolic process (GO:0006586)	5.43408314
15	negative regulation of interleukin-8 production (GO:0032717)	5.28175041
16	benzene-containing compound metabolic process (GO:0042537)	4.86635540
17	digestion (GO:0007586)	4.67223683
18	epithelial cell morphogenesis (GO:0003382)	4.41522872
19	negative regulation of T cell apoptotic process (GO:0070233)	4.41048675
20	positive regulation of cell-cell adhesion (GO:0022409)	4.34937021
21	aromatic amino acid family metabolic process (GO:0009072)	4.27742556
22	transepithelial transport (GO:0070633)	3.99482768
23	regulation of type 2 immune response (GO:0002828)	3.92429464
24	indole-containing compound metabolic process (GO:0042430)	3.88689622
25	regulation of clathrin-mediated endocytosis (GO:2000369)	3.77748354
26	reverse cholesterol transport (GO:0043691)	3.71089586
27	sulfur amino acid catabolic process (GO:0000098)	3.60957843
28	* negative regulation of endopeptidase activity (GO:0010951)	3.46247620
29	N-acetylneuraminate metabolic process (GO:0006054)	3.42841103
30	negative regulation of protein autophosphorylation (GO:0031953)	3.34060121
31	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.32398239
32	* negative regulation of peptidase activity (GO:0010466)	3.29828303
33	phospholipid homeostasis (GO:0055091)	3.23028768
34	alpha-linolenic acid metabolic process (GO:0036109)	3.15713654
35	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.14348785
36	regulation of macrophage activation (GO:0043030)	3.03681660
37	seminiferous tubule development (GO:0072520)	25.3418409
38	regulation of lipoprotein metabolic process (GO:0050746)	2.99711942
39	glial cell proliferation (GO:0014009)	2.83555474
40	cysteine metabolic process (GO:0006534)	2.75738472
41	regulation of beta-amyloid formation (GO:1902003)	2.74621344
42	sialylation (GO:0097503)	2.74377035
43	regulation of activated T cell proliferation (GO:0046006)	2.73675149
44	negative regulation of glycogen biosynthetic process (GO:0045719)	2.73608656
45	O-glycan processing (GO:0016266)	2.72243745
46	complement activation, alternative pathway (GO:0006957)	2.71817203
47	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.69310795
48	positive regulation of cellular amide metabolic process (GO:0034250)	2.67770227
49	high-density lipoprotein particle remodeling (GO:0034375)	2.67097076
50	positive regulation of interleukin-12 production (GO:0032735)	2.57668718
51	low-density lipoprotein particle clearance (GO:0034383)	2.57186193
52	columnar/cuboidal epithelial cell development (GO:0002066)	2.54248485
53	hormone catabolic process (GO:0042447)	2.53426328
54	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.47999969
55	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.47643094
56	negative regulation of glycogen metabolic process (GO:0070874)	2.47338877
57	L-serine transport (GO:0015825)	2.35795746
58	alpha-amino acid catabolic process (GO:1901606)	2.34256414
59	lipid catabolic process (GO:0016042)	2.32997750
60	valine metabolic process (GO:0006573)	2.32165428
61	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.30477565
62	negative regulation of interleukin-6 production (GO:0032715)	2.29703744
63	cellular amino acid catabolic process (GO:0009063)	2.26587058
64	response to misfolded protein (GO:0051788)	2.26046507
65	triglyceride catabolic process (GO:0019433)	2.24855665
66	regulation of T cell apoptotic process (GO:0070232)	2.24236977
67	* defense response to bacterium (GO:0042742)	2.22156017
68	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.21159738
69	L-phenylalanine catabolic process (GO:0006559)	2.21159738
70	* negative regulation of proteolysis (GO:0045861)	2.18862504
71	neutral lipid catabolic process (GO:0046461)	2.18605972
72	acylglycerol catabolic process (GO:0046464)	2.18605972
73	plasma lipoprotein particle remodeling (GO:0034369)	2.15389256
74	protein-lipid complex remodeling (GO:0034368)	2.15389256
75	macromolecular complex remodeling (GO:0034367)	2.15389256
76	regulation of interleukin-10 production (GO:0032653)	2.11608039
77	* negative regulation of protein processing (GO:0010955)	2.11206748
78	* negative regulation of protein maturation (GO:1903318)	2.11206748
79	myelin maintenance (GO:0043217)	2.11172560
80	Golgi transport vesicle coating (GO:0048200)	2.11023486
81	COPI coating of Golgi vesicle (GO:0048205)	2.11023486
82	positive regulation of sterol transport (GO:0032373)	2.11003250
83	positive regulation of cholesterol transport (GO:0032376)	2.11003250
84	negative regulation of T cell proliferation (GO:0042130)	2.06762173
85	cellular modified amino acid catabolic process (GO:0042219)	2.06747095
86	cellular response to epidermal growth factor stimulus (GO:0071364)	2.06097705
87	glutamate metabolic process (GO:0006536)	2.05576561
88	serine transport (GO:0032329)	2.04442601
89	regulation of reproductive process (GO:2000241)	2.02746135
90	activation of protein kinase A activity (GO:0034199)	2.02665109
91	regulation of lipoprotein particle clearance (GO:0010984)	2.00041475
92	production of molecular mediator involved in inflammatory response (GO:0002532)	14.4668174
93	regulation of T cell tolerance induction (GO:0002664)	14.4562440
94	positive regulation of tolerance induction (GO:0002645)	12.4002638
95	sperm capacitation (GO:0048240)	11.2795516
96	regulation of tolerance induction (GO:0002643)	10.7923589
97	kynurenine metabolic process (GO:0070189)	10.5471395
98	* negative regulation of hydrolase activity (GO:0051346)	1.99626612
99	regulation of apoptotic cell clearance (GO:2000425)	1.99335166
100	glutamine family amino acid catabolic process (GO:0009065)	1.97887575

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.82663607
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.26638454
3	IKZF1_21737484_ChIP-ChIP_HCT116_Human	4.09197612
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.25189758
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.16510160
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.68903342
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.63172830
8	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.58454279
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.55764520
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.46098652
11	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.37787788
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.33895953
13	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.12568725
14	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.09547842
15	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	2.08087509
16	CLOCK_20551151_ChIP-Seq_293T_Human	2.01692077
17	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.90164379
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84492372
19	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.78895060
20	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.71557811
21	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.70974497
22	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.70477781
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64229609
24	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.63335311
25	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.55816161
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.55434718
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.55434718
28	STAT1_17558387_ChIP-Seq_HELA_Human	1.51944821
29	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.50897030
30	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.50621183
31	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.48030295
32	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.47649899
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44610545
34	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.42939870
35	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.40736733
36	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.39765405
37	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.36524943
38	* SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.34330064
39	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.32564184
40	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.31438377
41	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30655442
42	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.29862328
43	* TET1_21451524_ChIP-Seq_MESCs_Mouse	1.29417195
44	P68_20966046_ChIP-Seq_HELA_Human	1.25499985
45	* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.22077478
46	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20699351
47	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.20422570
48	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.17468571
49	RACK7_27058665_Chip-Seq_MCF-7_Human	1.17303400
50	SMC4_20622854_ChIP-Seq_HELA_Human	1.17087210
51	* REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.17024236
52	VDR_24787735_ChIP-Seq_THP-1_Human	1.16454226
53	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.15574472
54	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.15572471
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.12472292
56	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.11868114
57	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.11154122
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11035569
59	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.10815399
60	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.08820749
61	MYC_19915707_ChIP-ChIP_AK7_Human	1.08083416
62	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.07592866
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.07380839
64	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05095694
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04848523
66	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.04412972
67	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03962815
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01951408
69	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.01103414
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01061992
71	BCL6_27268052_Chip-Seq_Bcells_Human	0.99806933
72	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.99740513
73	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99698290
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99469606
75	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99009610
76	* GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.98988853
77	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.97808598
78	KDM2B_26808549_Chip-Seq_REH_Human	0.96960750
79	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.96942445
80	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95446260
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95383270
82	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.95318784
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95318020
84	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.94032392
85	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93911948
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93124413
87	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.92209989
88	* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91353046
89	KDM2B_26808549_Chip-Seq_K562_Human	0.90961683
90	LXR_22292898_ChIP-Seq_THP-1_Human	0.90833987
91	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.89939165
92	P300_27268052_Chip-Seq_Bcells_Human	0.88699201
93	GATA1_19941826_ChIP-Seq_K562_Human	0.86391037
94	BCOR_27268052_Chip-Seq_Bcells_Human	0.86333785
95	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.86318835
96	RAC3_21632823_ChIP-Seq_H3396_Human	0.86215463
97	SOX2_20726797_ChIP-Seq_SW620_Human	0.86185918
98	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.85279638
99	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.84260863
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.81491475

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	5.76790310
2	MP0003195_calcinosis	5.19498467
3	MP0002254_reproductive_system_inflammat	4.95113719
4	MP0004043_abnormal_pH_regulation	4.71276793
5	MP0010234_abnormal_vibrissa_follicle	4.20173537
6	MP0002139_abnormal_hepatobiliary_system	4.16485209
7	MP0005410_abnormal_fertilization	3.34036186
8	MP0005058_abnormal_lysosome_morphology	3.16362955
9	MP0003329_amyloid_beta_deposits	3.04437925
10	MP0000003_abnormal_adipose_tissue	2.16416009
11	MP0005360_urolithiasis	2.14958680
12	MP0000604_amyloidosis	2.08210881
13	MP0010329_abnormal_lipoprotein_level	2.05407021
14	MP0002168_other_aberrant_phenotype	1.98251099
15	MP0005365_abnormal_bile_salt	1.82270619
16	MP0003300_gastrointestinal_ulcer	1.80036340
17	MP0003566_abnormal_cell_adhesion	1.73786217
18	MP0004885_abnormal_endolymph	1.69613724
19	MP0001501_abnormal_sleep_pattern	1.59717429
20	MP0005085_abnormal_gallbladder_physiolo	1.57751231
21	MP0004130_abnormal_muscle_cell	1.56425732
22	MP0001765_abnormal_ion_homeostasis	1.54009786
23	MP0004859_abnormal_synaptic_plasticity	1.52277883
24	MP0005375_adipose_tissue_phenotype	1.51735737
25	MP0002837_dystrophic_cardiac_calcinosis	1.49653882
26	MP0001440_abnormal_grooming_behavior	1.47688263
27	MP0001853_heart_inflammation	1.43217641
28	MP0000534_abnormal_ureter_morphology	1.39025726
29	MP0003690_abnormal_glial_cell	1.38695932
30	MP0009643_abnormal_urine_homeostasis	1.34282510
31	MP0004858_abnormal_nervous_system	1.32627959
32	MP0003705_abnormal_hypodermis_morpholog	1.30479527
33	MP0004185_abnormal_adipocyte_glucose	1.27125085
34	MP0005332_abnormal_amino_acid	1.26974931
35	MP0005083_abnormal_biliary_tract	1.24393642
36	MP0002118_abnormal_lipid_homeostasis	1.18179990
37	MP0008438_abnormal_cutaneous_collagen	1.17933591
38	MP0002089_abnormal_postnatal_growth/wei	1.17572740
39	MP0000537_abnormal_urethra_morphology	1.15221190
40	MP0005584_abnormal_enzyme/coenzyme_acti	1.15008473
41	MP0001756_abnormal_urination	1.14607978
42	MP0004270_analgesia	1.14260214
43	MP0005275_abnormal_skin_tensile	1.11986695
44	MP0003191_abnormal_cellular_cholesterol	1.06952174
45	MP0002896_abnormal_bone_mineralization	1.06402009
46	MP0002796_impaired_skin_barrier	1.02954362
47	MP0003806_abnormal_nucleotide_metabolis	1.01968191
48	MP0009780_abnormal_chondrocyte_physiolo	1.00849163
49	MP0003252_abnormal_bile_duct	1.00152016
50	MP0005636_abnormal_mineral_homeostasis	0.99498899
51	MP0003632_abnormal_nervous_system	0.98469226
52	MP0004145_abnormal_muscle_electrophysio	0.96768468
53	MP0002909_abnormal_adrenal_gland	0.96419568
54	MP0005666_abnormal_adipose_tissue	0.94556350
55	MP0008875_abnormal_xenobiotic_pharmacok	0.94203810
56	MP0003075_altered_response_to	0.94126733
57	MP0003698_abnormal_male_reproductive	0.93172470
58	MP0003879_abnormal_hair_cell	0.92893170
59	MP0000920_abnormal_myelination	0.92281076
60	MP0002733_abnormal_thermal_nociception	0.87786708
61	MP0000747_muscle_weakness	0.85542976
62	MP0002136_abnormal_kidney_physiology	0.82554268
63	MP0002876_abnormal_thyroid_physiology	0.82382810
64	MP0002933_joint_inflammation	0.79574632
65	MP0003635_abnormal_synaptic_transmissio	0.78635384
66	MP0004036_abnormal_muscle_relaxation	0.78552607
67	MP0003631_nervous_system_phenotype	0.78284011
68	MP0000609_abnormal_liver_physiology	0.77151516
69	MP0003633_abnormal_nervous_system	0.74295910
70	MP0005319_abnormal_enzyme/_coenzyme	0.71813656
71	MP0005395_other_phenotype	0.68812548
72	MP0002735_abnormal_chemical_nociception	0.68376161
73	MP0005670_abnormal_white_adipose	0.68145782
74	MP0005623_abnormal_meninges_morphology	0.67189960
75	MP0010678_abnormal_skin_adnexa	0.65851706
76	MP0009840_abnormal_foam_cell	0.64846726
77	MP0002272_abnormal_nervous_system	0.63704703
78	MP0009384_cardiac_valve_regurgitation	0.63682561
79	MP0005535_abnormal_body_temperature	0.63566251
80	MP0003634_abnormal_glial_cell	0.62919002
81	MP0000538_abnormal_urinary_bladder	0.62626401
82	MP0005334_abnormal_fat_pad	0.61565218
83	MP0000462_abnormal_digestive_system	0.60619294
84	MP0002971_abnormal_brown_adipose	0.60403535
85	MP0000249_abnormal_blood_vessel	0.59658953
86	MP0002009_preneoplasia	0.58692889
87	MP0001970_abnormal_pain_threshold	0.58691197
88	MP0002295_abnormal_pulmonary_circulatio	0.58028919
89	MP0001666_abnormal_nutrient_absorption	0.56882172
90	MP0000751_myopathy	0.56254885
91	MP0004272_abnormal_basement_membrane	0.55900281
92	MP0002064_seizures	0.54054414
93	MP0009053_abnormal_anal_canal	0.53644914
94	MP0002653_abnormal_ependyma_morphology	0.52284541
95	MP0005166_decreased_susceptibility_to	0.51608191
96	MP0003959_abnormal_lean_body	0.51506592
97	MP0002161_abnormal_fertility/fecundity	0.50271560
98	MP0000013_abnormal_adipose_tissue	0.49987711
99	MP0004087_abnormal_muscle_fiber	0.48873856
100	MP0004084_abnormal_cardiac_muscle	0.48663537

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myocardial infarction (HP:0001658)	5.38065697
2	Hypophosphatemic rickets (HP:0004912)	5.11509708
3	Facial shape deformation (HP:0011334)	4.82164734
4	Potter facies (HP:0002009)	4.82164734
5	Vascular calcification (HP:0004934)	4.73817743
6	Complement deficiency (HP:0004431)	4.60478904
7	Cardiovascular calcification (HP:0011915)	4.41713011
8	Neurofibrillary tangles (HP:0002185)	4.32886639
9	Cerebral inclusion bodies (HP:0100314)	4.19676517
10	Malnutrition (HP:0004395)	3.94677916
11	Choroideremia (HP:0001139)	3.77365299
12	Neoplasm of the heart (HP:0100544)	3.56305752
13	Abnormality of complement system (HP:0005339)	3.34342630
14	Infantile muscular hypotonia (HP:0008947)	3.26158472
15	Recurrent gram-negative bacterial infections (HP:0005420)	3.22127724
16	Supranuclear gaze palsy (HP:0000605)	3.19904128
17	Widely patent fontanelles and sutures (HP:0004492)	3.19066691
18	Xanthomatosis (HP:0000991)	3.16037212
19	Intention tremor (HP:0002080)	3.15692804
20	Rickets (HP:0002748)	3.14759633
21	Agitation (HP:0000713)	3.07559274
22	Deep venous thrombosis (HP:0002625)	3.05879622
23	Choreoathetosis (HP:0001266)	3.05805950
24	Hemiplegia (HP:0002301)	2.75938959
25	Ketoacidosis (HP:0001993)	2.66467497
26	Polar cataract (HP:0010696)	2.49275410
27	Abnormality of the fovea (HP:0000493)	2.48560636
28	Ketosis (HP:0001946)	2.48183337
29	Difficulty running (HP:0009046)	2.41602269
30	Intrahepatic cholestasis (HP:0001406)	2.41292123
31	Gout (HP:0001997)	2.40500573
32	Hemorrhage of the eye (HP:0011885)	2.38816987
33	Vacuolated lymphocytes (HP:0001922)	2.37330929
34	Hypopigmentation of the fundus (HP:0007894)	2.36887436
35	Testicular atrophy (HP:0000029)	2.33693014
36	Peripheral hypomyelination (HP:0007182)	2.32929516
37	Skin nodule (HP:0200036)	2.30476101
38	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.28486080
39	Hyporeflexia of lower limbs (HP:0002600)	2.25844611
40	Hyperglycinuria (HP:0003108)	2.24056376
41	Acanthosis nigricans (HP:0000956)	2.23018506
42	Abnormality of purine metabolism (HP:0004352)	2.21569207
43	Abnormal hemoglobin (HP:0011902)	2.18868059
44	Osteomalacia (HP:0002749)	2.16369742
45	Gait ataxia (HP:0002066)	2.12358205
46	Epidermoid cyst (HP:0200040)	2.11758516
47	Ulnar claw (HP:0001178)	2.09407786
48	Hyperlipoproteinemia (HP:0010980)	2.06997457
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.04320812
50	Thin bony cortex (HP:0002753)	2.04194450
51	Hepatoblastoma (HP:0002884)	2.04011185
52	Focal segmental glomerulosclerosis (HP:0000097)	2.03704062
53	Spastic diplegia (HP:0001264)	2.01112565
54	Myokymia (HP:0002411)	2.00561530
55	Abnormality of glycine metabolism (HP:0010895)	1.98357384
56	Abnormality of serine family amino acid metabolism (HP:0010894)	1.98357384
57	Hyperparathyroidism (HP:0000843)	1.98254655
58	Right ventricular cardiomyopathy (HP:0011663)	1.94094034
59	Segmental peripheral demyelination/remyelination (HP:0003481)	1.93239992
60	Muscle fiber splitting (HP:0003555)	1.90499052
61	Dysostosis multiplex (HP:0000943)	1.90045144
62	Wide cranial sutures (HP:0010537)	1.86563925
63	Ectopia lentis (HP:0001083)	1.86411589
64	Hypertriglyceridemia (HP:0002155)	1.86171326
65	Systemic lupus erythematosus (HP:0002725)	1.84905926
66	Hyperammonemia (HP:0001987)	1.84901431
67	Increased connective tissue (HP:0009025)	1.84535696
68	Prominent nose (HP:0000448)	1.84422586
69	Restlessness (HP:0000711)	1.82064254
70	Hypoalphalipoproteinemia (HP:0003233)	1.81135556
71	Hyperphosphatemia (HP:0002905)	1.81057347
72	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.80102707
73	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.80102707
74	Hypophosphatemia (HP:0002148)	1.78167936
75	Pili torti (HP:0003777)	1.77153912
76	Glomerulosclerosis (HP:0000096)	1.76695812
77	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.75414767
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.75327219
79	Gastrointestinal dysmotility (HP:0002579)	1.75178406
80	Psychosis (HP:0000709)	1.74045777
81	Increased CSF protein (HP:0002922)	1.72120614
82	Progressive neurologic deterioration (HP:0002344)	1.71931506
83	Oligomenorrhea (HP:0000876)	1.69173628
84	Tubulointerstitial fibrosis (HP:0005576)	1.68613861
85	Amyloidosis (HP:0011034)	1.68373781
86	Turricephaly (HP:0000262)	1.67847855
87	Abnormality of the periventricular white matter (HP:0002518)	1.65534908
88	Calf muscle hypertrophy (HP:0008981)	1.63262115
89	Abnormal cartilage morphology (HP:0002763)	1.60720935
90	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.59785544
91	Abnormality of the Achilles tendon (HP:0005109)	1.59612754
92	Hyperglycinemia (HP:0002154)	1.59590905
93	Subcapsular cataract (HP:0000523)	1.59394724
94	Prominent forehead (HP:0011220)	1.59177067
95	Abnormality of transition element cation homeostasis (HP:0011030)	1.59069815
96	Abdominal situs inversus (HP:0003363)	1.57656628
97	Abnormality of abdominal situs (HP:0011620)	1.57656628
98	Back pain (HP:0003418)	1.56799822
99	Loss of speech (HP:0002371)	1.56422926
100	Rectal prolapse (HP:0002035)	1.54906474

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.67436197
2	ERN1	3.32583923
3	LMTK2	3.19311270
4	EPHB1	2.85626575
5	SIK1	2.62065526
6	PKN2	2.49579038
7	LRRK2	2.37191906
8	FGFR2	2.20455725
9	TRIB3	2.19942882
10	PDGFRA	2.19821399
11	FER	2.15508988
12	FGFR4	1.96351856
13	TAOK3	1.88415975
14	STK39	1.87658338
15	WNK4	1.82573684
16	PRKD3	1.82490977
17	MAP3K2	1.58441074
18	PTK6	1.50492389
19	TNK2	1.43629266
20	EPHA2	1.42064480
21	NTRK3	1.38410336
22	TTN	1.37492513
23	RET	1.37321981
24	TYRO3	1.35662382
25	PTK2B	1.30374874
26	RIPK4	1.26868784
27	NTRK1	1.25347285
28	PAK3	1.24343710
29	PTK2	1.18917823
30	MAP2K4	1.16843840
31	MYLK	1.16170574
32	INSR	1.13670527
33	SCYL2	1.13008595
34	STK10	1.12277128
35	PAK6	1.08804203
36	CDK19	1.08702115
37	KSR2	1.08632234
38	TESK1	1.07328280
39	PRKCH	1.07283172
40	FGFR3	0.98042029
41	BCKDK	0.96772117
42	FRK	0.96341866
43	MAP3K7	0.91275881
44	DMPK	0.88959192
45	LATS2	0.86607457
46	EPHB2	0.85307956
47	PAK4	0.83845918
48	CDK5	0.83711846
49	ALK	0.82356477
50	ICK	0.81974016
51	PAK2	0.80749361
52	MAP3K12	0.78969746
53	EPHA4	0.78326134
54	SIK2	0.77341957
55	MAP3K6	0.76170182
56	NTRK2	0.72899469
57	CAMK1G	0.72794708
58	PDK4	0.72658902
59	PDK3	0.72658902
60	MAP2K1	0.71199663
61	WNK1	0.71176959
62	PRKCG	0.69941817
63	PHKG2	0.68989156
64	PHKG1	0.68989156
65	MINK1	0.68570178
66	DAPK2	0.68402131
67	GSK3A	0.67779212
68	DDR2	0.66223499
69	JAK2	0.64838642
70	ROCK2	0.62681908
71	FGFR1	0.62551432
72	SRC	0.61306843
73	UHMK1	0.60885122
74	PDGFRB	0.60829402
75	STK38	0.60629755
76	FYN	0.59078708
77	FLT3	0.58279936
78	PRKD1	0.58055806
79	LATS1	0.56989709
80	AKT3	0.55960753
81	EEF2K	0.55176120
82	PRKCZ	0.54967727
83	PRKACG	0.54706661
84	FES	0.53703498
85	CDK6	0.52738754
86	CSNK1E	0.52429889
87	MET	0.50487874
88	MARK1	0.50165628
89	MAP3K9	0.49263496
90	ERBB2	0.48999704
91	EGFR	0.47578233
92	MAP3K13	0.46420887
93	RIPK1	0.45950280
94	PRKCQ	0.45008611
95	CSK	0.43098110
96	PDK1	0.42622873
97	CAMK1D	0.41751178
98	GRK5	0.41424573
99	JAK1	0.39550000
100	PDPK1	0.38431740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.22576270
2	Glutathione metabolism_Homo sapiens_hsa00480	4.29672334
3	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.47711956
4	Tryptophan metabolism_Homo sapiens_hsa00380	3.47502921
5	Thyroid hormone synthesis_Homo sapiens_hsa04918	3.39859735
6	African trypanosomiasis_Homo sapiens_hsa05143	3.30173358
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.08670500
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.72844817
9	Sulfur metabolism_Homo sapiens_hsa00920	2.01923857
10	Fatty acid degradation_Homo sapiens_hsa00071	1.98413944
11	Fatty acid metabolism_Homo sapiens_hsa01212	1.95323322
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.86810582
13	PPAR signaling pathway_Homo sapiens_hsa03320	1.62915602
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57782139
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.54454292
16	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50272505
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40009276
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37020693
19	Salivary secretion_Homo sapiens_hsa04970	1.32306897
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.30399957
21	Propanoate metabolism_Homo sapiens_hsa00640	1.15066587
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12307975
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10830909
24	Complement and coagulation cascades_Homo sapiens_hsa04610	1.09653907
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08676238
26	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.04818428
27	Renin secretion_Homo sapiens_hsa04924	1.04469142
28	Gastric acid secretion_Homo sapiens_hsa04971	1.02739514
29	Butanoate metabolism_Homo sapiens_hsa00650	0.99600030
30	Lysosome_Homo sapiens_hsa04142	0.97832760
31	Bile secretion_Homo sapiens_hsa04976	0.97348905
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96888652
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95667922
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93910838
35	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.93808463
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93023752
37	Pyruvate metabolism_Homo sapiens_hsa00620	0.91823304
38	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88431312
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.87993241
40	GABAergic synapse_Homo sapiens_hsa04727	0.87937396
41	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.84956539
42	Long-term potentiation_Homo sapiens_hsa04720	0.84831447
43	Phenylalanine metabolism_Homo sapiens_hsa00360	0.82148098
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.78524292
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.75603598
46	Vibrio cholerae infection_Homo sapiens_hsa05110	0.75051642
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74814210
48	Circadian entrainment_Homo sapiens_hsa04713	0.70741570
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67339080
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66643236
51	Prion diseases_Homo sapiens_hsa05020	0.66004520
52	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64479349
53	Fatty acid elongation_Homo sapiens_hsa00062	0.64231143
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62153926
55	Histidine metabolism_Homo sapiens_hsa00340	0.61977244
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61350725
57	Carbon metabolism_Homo sapiens_hsa01200	0.59012387
58	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.58802021
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58106980
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55646958
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.54015032
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53061826
63	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52931785
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.51586664
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51117719
66	Amphetamine addiction_Homo sapiens_hsa05031	0.50733330
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.49141698
68	Folate biosynthesis_Homo sapiens_hsa00790	0.46039966
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45948081
70	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.45833024
71	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.45289621
72	Peroxisome_Homo sapiens_hsa04146	0.42848149
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41516007
74	Insulin secretion_Homo sapiens_hsa04911	0.41282591
75	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40528911
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39971056
77	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.38178577
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37898561
79	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37715984
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.37638431
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37457598
82	GnRH signaling pathway_Homo sapiens_hsa04912	0.36451601
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35293494
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.35217078
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.34663831
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34559905
87	Glioma_Homo sapiens_hsa05214	0.34452285
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.33310463
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33275305
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33060462
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.32999547
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.31983076
93	ABC transporters_Homo sapiens_hsa02010	0.31815886
94	Cholinergic synapse_Homo sapiens_hsa04725	0.30019974
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.28634917
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28506438
97	Olfactory transduction_Homo sapiens_hsa04740	0.28139446
98	Melanogenesis_Homo sapiens_hsa04916	0.27322654
99	Insulin resistance_Homo sapiens_hsa04931	0.26206486
100	Type II diabetes mellitus_Homo sapiens_hsa04930	0.24838536

CST11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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