CST5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1high-density lipoprotein particle remodeling (GO:0034375)8.98388721
2phospholipid efflux (GO:0033700)8.96091175
3regulation of triglyceride catabolic process (GO:0010896)7.92125547
4reverse cholesterol transport (GO:0043691)7.67986078
5plasma lipoprotein particle assembly (GO:0034377)7.06853529
6regulation of cholesterol esterification (GO:0010872)6.56318617
7very-low-density lipoprotein particle assembly (GO:0034379)6.38153336
8protein-lipid complex assembly (GO:0065005)6.31816235
9negative regulation of lipase activity (GO:0060192)6.20688914
10cholesterol efflux (GO:0033344)5.67186067
11plasma lipoprotein particle remodeling (GO:0034369)5.44468099
12protein-lipid complex remodeling (GO:0034368)5.44468099
13macromolecular complex remodeling (GO:0034367)5.44468099
14negative regulation of fatty acid biosynthetic process (GO:0045717)5.26302451
15peptidyl-glutamic acid carboxylation (GO:0017187)5.18924231
16protein carboxylation (GO:0018214)5.18924231
17negative regulation of sterol transport (GO:0032372)4.53530367
18negative regulation of cholesterol transport (GO:0032375)4.53530367
19plasma lipoprotein particle clearance (GO:0034381)4.50367032
20xenobiotic catabolic process (GO:0042178)4.36350061
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.34320667
22transepithelial transport (GO:0070633)4.26813858
23water-soluble vitamin biosynthetic process (GO:0042364)4.26695901
24progesterone metabolic process (GO:0042448)4.23410600
25regulation of lipoprotein metabolic process (GO:0050746)4.18671999
26cellular response to zinc ion (GO:0071294)4.12668735
27galactose catabolic process (GO:0019388)4.10792786
28positive regulation of prostaglandin secretion (GO:0032308)4.07456153
29cellular response to exogenous dsRNA (GO:0071360)4.03841298
30regulation of metalloenzyme activity (GO:0048552)3.98750056
31positive regulation of lipoprotein lipase activity (GO:0051006)3.98259242
32positive regulation of triglyceride lipase activity (GO:0061365)3.98259242
33plasma lipoprotein particle organization (GO:0071827)3.96701722
34membrane raft organization (GO:0031579)3.93721628
35galactose metabolic process (GO:0006012)3.85799632
36protein maturation by protein folding (GO:0022417)3.76897475
37protein-lipid complex subunit organization (GO:0071825)3.74569368
38regulation of interferon-beta biosynthetic process (GO:0045357)3.72399092
394-hydroxyproline metabolic process (GO:0019471)3.70649364
40membrane budding (GO:0006900)3.70244032
41L-ascorbic acid metabolic process (GO:0019852)3.66616218
42oligosaccharide catabolic process (GO:0009313)3.59439784
43lipoprotein transport (GO:0042953)3.59435504
44regulation of extracellular matrix disassembly (GO:0010715)3.59072775
45regulation of fatty acid biosynthetic process (GO:0042304)3.57775058
46regulation of lipoprotein particle clearance (GO:0010984)3.45328270
47proteasome assembly (GO:0043248)3.41421470
48regulation of triglyceride metabolic process (GO:0090207)3.29288994
49regulation of prostaglandin secretion (GO:0032306)3.29092128
50response to phenylpropanoid (GO:0080184)3.28271960
51glutathione derivative biosynthetic process (GO:1901687)3.26075691
52glutathione derivative metabolic process (GO:1901685)3.26075691
53removal of superoxide radicals (GO:0019430)3.25929872
54cellular response to superoxide (GO:0071451)3.25929872
55cellular response to oxygen radical (GO:0071450)3.25929872
56acylglycerol homeostasis (GO:0055090)3.25338956
57triglyceride homeostasis (GO:0070328)3.25338956
58polyol transport (GO:0015791)3.24831223
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.23060217
60sterol transport (GO:0015918)3.17099575
61cholesterol transport (GO:0030301)3.17099575
62positive regulation of protein targeting to membrane (GO:0090314)3.15746717
63negative regulation of receptor-mediated endocytosis (GO:0048261)3.10436254
64positive regulation of guanylate cyclase activity (GO:0031284)3.10244954
65glutamine family amino acid biosynthetic process (GO:0009084)3.08360415
66nephron epithelium morphogenesis (GO:0072088)3.06980945
67nephron tubule morphogenesis (GO:0072078)3.06980945
68autophagic vacuole fusion (GO:0000046)3.05294107
69positive regulation of chemokine biosynthetic process (GO:0045080)2.94007151
70regulation of sterol transport (GO:0032371)2.92782714
71regulation of cholesterol transport (GO:0032374)2.92782714
72macrophage activation involved in immune response (GO:0002281)2.90117560
73C21-steroid hormone metabolic process (GO:0008207)2.89405357
74positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.88282952
75regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.87723700
76negative regulation of fatty acid metabolic process (GO:0045922)2.86894966
77negative regulation of metanephros development (GO:0072217)2.86044638
78cellular response to interferon-beta (GO:0035458)2.85578115
79regulation of guanylate cyclase activity (GO:0031282)2.75614333
80organelle membrane fusion (GO:0090174)2.74052974
81cholesterol homeostasis (GO:0042632)2.71598523
82ribonucleoside diphosphate metabolic process (GO:0009185)2.68811005
83positive regulation of fatty acid biosynthetic process (GO:0045723)2.68517635
84lipoprotein metabolic process (GO:0042157)2.67680690
85nucleoside diphosphate catabolic process (GO:0009134)2.67559910
86sterol homeostasis (GO:0055092)2.65851233
87positive regulation of lipid catabolic process (GO:0050996)2.65584790
88protein heterotetramerization (GO:0051290)2.64294362
89purine nucleoside diphosphate metabolic process (GO:0009135)2.64282394
90purine ribonucleoside diphosphate metabolic process (GO:0009179)2.64282394
91phototransduction, visible light (GO:0007603)2.63844840
92DNA damage response, detection of DNA damage (GO:0042769)2.59934610
93sleep (GO:0030431)2.59832817
94regulation of lipoprotein lipase activity (GO:0051004)2.59392584
95positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.56967531
96retinoid metabolic process (GO:0001523)2.56328061
97glucosamine-containing compound catabolic process (GO:1901072)2.55918092
98keratan sulfate catabolic process (GO:0042340)2.52680893
99regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.52426069
100negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51989723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HIF1A_21447827_ChIP-Seq_MCF-7_Human5.98892610
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.80636478
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70672896
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56778584
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37403037
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.24807691
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.95222140
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94886485
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.90745113
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.69581333
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39779253
12TP53_16413492_ChIP-PET_HCT116_Human2.13813895
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08136740
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.05615585
15GATA1_22025678_ChIP-Seq_K562_Human2.05113351
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98338011
17ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.96717180
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96211180
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90007904
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.88029684
21SOX2_20726797_ChIP-Seq_SW620_Human1.87829408
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83274179
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73216549
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73155474
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70611102
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69825851
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.68256892
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68133973
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67830104
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67547918
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67547918
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.63326079
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62009136
34GATA4_25053715_ChIP-Seq_YYC3_Human1.61169852
35VDR_22108803_ChIP-Seq_LS180_Human1.57633623
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54292804
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.51542330
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50514683
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49531351
40JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49264776
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.48539368
42FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46038330
43GATA6_25053715_ChIP-Seq_YYC3_Human1.44892933
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42219916
45ATF3_27146783_Chip-Seq_COLON_Human1.41146421
46TP53_18474530_ChIP-ChIP_U2OS_Human1.37962502
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37547997
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36947985
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.36947985
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36692394
51EOMES_21245162_ChIP-Seq_HESCs_Human1.32745595
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28080718
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27216878
54GATA6_21074721_ChIP-Seq_CACO-2_Human1.25849897
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24216553
56GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23990352
57CSB_26484114_Chip-Seq_FIBROBLAST_Human1.23360449
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22907518
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22567373
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.16076110
61RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15629743
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15360443
63RBPJ_21746931_ChIP-Seq_IB4_Human1.13339658
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13128356
65PHF8_20622853_ChIP-Seq_HELA_Human1.11760316
66SA1_27219007_Chip-Seq_Bcells_Human1.10878345
67CJUN_26792858_Chip-Seq_BT549_Human1.10298705
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09117110
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07368881
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.07248892
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07008719
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06876183
73CTCF_27219007_Chip-Seq_Bcells_Human1.06582803
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03054369
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02996193
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02297386
77NANOG_20526341_ChIP-Seq_ESCs_Human1.02089436
78P300_27268052_Chip-Seq_Bcells_Human1.02029333
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01791778
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01569990
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00630484
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99927638
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99493595
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95919908
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95423875
86HNFA_21074721_ChIP-Seq_CACO-2_Human0.94964464
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94960959
88RACK7_27058665_Chip-Seq_MCF-7_Human0.94919409
89E2F1_20622854_ChIP-Seq_HELA_Human0.94330103
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.92441297
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91371726
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90516422
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90087726
94CBP_21632823_ChIP-Seq_H3396_Human0.90087648
95ELF5_23300383_ChIP-Seq_T47D_Human0.90016866
96CEBPB_22108803_ChIP-Seq_LS180_Human0.89424296
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88818402
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88637332
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88627073
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87363471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell9.46318350
2MP0005360_urolithiasis7.23722504
3MP0003191_abnormal_cellular_cholesterol3.67004289
4MP0002139_abnormal_hepatobiliary_system2.88811414
5MP0008875_abnormal_xenobiotic_pharmacok2.80660435
6MP0004019_abnormal_vitamin_homeostasis2.75839917
7MP0010329_abnormal_lipoprotein_level2.65866136
8MP0003878_abnormal_ear_physiology2.56516694
9MP0005377_hearing/vestibular/ear_phenot2.56516694
10MP0002876_abnormal_thyroid_physiology2.30494320
11MP0003183_abnormal_peptide_metabolism2.13594567
12MP0005257_abnormal_intraocular_pressure2.11877971
13MP0004270_analgesia2.08295464
14MP0005084_abnormal_gallbladder_morpholo1.97908667
15MP0005083_abnormal_biliary_tract1.93868738
16MP0003252_abnormal_bile_duct1.83804037
17MP0002909_abnormal_adrenal_gland1.81950943
18MP0005332_abnormal_amino_acid1.81146660
19MP0003950_abnormal_plasma_membrane1.76415479
20MP0001666_abnormal_nutrient_absorption1.69679966
21MP0004145_abnormal_muscle_electrophysio1.64183722
22MP0001873_stomach_inflammation1.64147800
23MP0005365_abnormal_bile_salt1.49424562
24MP0004272_abnormal_basement_membrane1.44879772
25MP0005367_renal/urinary_system_phenotyp1.40879358
26MP0000516_abnormal_urinary_system1.40879358
27MP0005085_abnormal_gallbladder_physiolo1.40348912
28MP0005379_endocrine/exocrine_gland_phen1.39323982
29MP0000647_abnormal_sebaceous_gland1.36831277
30MP0010386_abnormal_urinary_bladder1.36033212
31MP0005165_increased_susceptibility_to1.35610081
32MP0003638_abnormal_response/metabolism_1.29127965
33MP0001905_abnormal_dopamine_level1.28158193
34MP0003718_maternal_effect1.27209048
35MP0002163_abnormal_gland_morphology1.27203737
36MP0009643_abnormal_urine_homeostasis1.26473366
37MP0001542_abnormal_bone_strength1.25844076
38MP0005584_abnormal_enzyme/coenzyme_acti1.24911377
39MP0004147_increased_porphyrin_level1.22814561
40MP0000372_irregular_coat_pigmentation1.17750950
41MP0000343_altered_response_to1.17573024
42MP0004264_abnormal_extraembryonic_tissu1.15848719
43MP0003195_calcinosis1.15699284
44MP0006082_CNS_inflammation1.12651518
45MP0001958_emphysema1.10636232
46MP0002138_abnormal_hepatobiliary_system1.04907827
47MP0010030_abnormal_orbit_morphology0.99297653
48MP0005551_abnormal_eye_electrophysiolog0.99044590
49MP0002877_abnormal_melanocyte_morpholog0.97646023
50MP0005636_abnormal_mineral_homeostasis0.96679486
51MP0002118_abnormal_lipid_homeostasis0.94408352
52MP0002295_abnormal_pulmonary_circulatio0.93885160
53MP0000383_abnormal_hair_follicle0.90676521
54MP0005164_abnormal_response_to0.88654894
55MP0000639_abnormal_adrenal_gland0.85723958
56MP0004133_heterotaxia0.85703400
57MP0010678_abnormal_skin_adnexa0.84897975
58MP0000249_abnormal_blood_vessel0.84113984
59MP0000427_abnormal_hair_cycle0.83604844
60MP0003075_altered_response_to0.83518565
61MP0005395_other_phenotype0.82996459
62MP0006072_abnormal_retinal_apoptosis0.82111722
63MP0001853_heart_inflammation0.81314339
64MP0001756_abnormal_urination0.76532045
65MP0003283_abnormal_digestive_organ0.75816561
66MP0002148_abnormal_hypersensitivity_rea0.74100516
67MP0009780_abnormal_chondrocyte_physiolo0.73608871
68MP0003786_premature_aging0.72817550
69MP0000003_abnormal_adipose_tissue0.71131181
70MP0001664_abnormal_digestion0.70416651
71MP0006036_abnormal_mitochondrial_physio0.69837007
72MP0003806_abnormal_nucleotide_metabolis0.69396869
73MP0009642_abnormal_blood_homeostasis0.67308361
74MP0003186_abnormal_redox_activity0.66999563
75MP0002160_abnormal_reproductive_system0.65477329
76MP0002254_reproductive_system_inflammat0.64639991
77MP0002693_abnormal_pancreas_physiology0.64347529
78MP0002928_abnormal_bile_duct0.64157808
79MP0005330_cardiomyopathy0.63843781
80MP0003123_paternal_imprinting0.62242269
81MP0004142_abnormal_muscle_tone0.62217980
82MP0005220_abnormal_exocrine_pancreas0.62186470
83MP0005187_abnormal_penis_morphology0.61261409
84MP0008469_abnormal_protein_level0.60620734
85MP0002136_abnormal_kidney_physiology0.60215811
86MP0005166_decreased_susceptibility_to0.58353731
87MP0001764_abnormal_homeostasis0.57966340
88MP0000609_abnormal_liver_physiology0.57659265
89MP0004782_abnormal_surfactant_physiolog0.56975853
90MP0003936_abnormal_reproductive_system0.55026848
91MP0004484_altered_response_of0.55015640
92MP0002168_other_aberrant_phenotype0.54835790
93MP0004883_abnormal_blood_vessel0.54506270
94MP0005448_abnormal_energy_balance0.52408993
95MP0003045_fibrosis0.51552192
96MP0005389_reproductive_system_phenotype0.50911181
97MP0002557_abnormal_social/conspecific_i0.50792275
98MP0001881_abnormal_mammary_gland0.49249057
99MP0008995_early_reproductive_senescence0.48982383
100MP0001919_abnormal_reproductive_system0.48016384

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)7.00629456
2Hyperlipoproteinemia (HP:0010980)4.70629373
3Hypolipoproteinemia (HP:0010981)4.58535977
4Vacuolated lymphocytes (HP:0001922)4.40290452
5Entropion (HP:0000621)4.39487525
6Abnormality of glycolipid metabolism (HP:0010969)4.30999704
7Abnormality of liposaccharide metabolism (HP:0010968)4.30999704
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.30999704
9Joint hemorrhage (HP:0005261)4.24761098
10Malnutrition (HP:0004395)3.94281314
11Amyloidosis (HP:0011034)3.84793997
12Glucose intolerance (HP:0000833)3.82432965
13Delayed CNS myelination (HP:0002188)3.58207151
14Prolonged neonatal jaundice (HP:0006579)3.47284366
15Type I transferrin isoform profile (HP:0003642)3.37464165
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35176350
17Vascular calcification (HP:0004934)3.29594055
18Hyperglycinemia (HP:0002154)3.29273185
19Gout (HP:0001997)3.09884020
20Gingival bleeding (HP:0000225)3.07516313
21Unilateral renal agenesis (HP:0000122)3.05549141
22Hypoplasia of the uterus (HP:0000013)3.05298008
23Pigmentary retinal degeneration (HP:0001146)3.03984901
24Abnormality of the common coagulation pathway (HP:0010990)3.03884200
25Abnormality of the prostate (HP:0008775)3.02584672
26Reduced antithrombin III activity (HP:0001976)2.95209724
27J-shaped sella turcica (HP:0002680)2.93606174
28Abnormal protein glycosylation (HP:0012346)2.92090224
29Abnormal glycosylation (HP:0012345)2.92090224
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92090224
31Abnormal protein N-linked glycosylation (HP:0012347)2.92090224
32Ureteral stenosis (HP:0000071)2.91754222
33Ureteral obstruction (HP:0006000)2.83906559
34Prolonged partial thromboplastin time (HP:0003645)2.80945127
35Cardiovascular calcification (HP:0011915)2.76184397
36Abnormality of macrophages (HP:0004311)2.74716962
37Abnormality of pyrimidine metabolism (HP:0004353)2.72652946
38Dysostosis multiplex (HP:0000943)2.71255799
39Nuclear cataract (HP:0100018)2.68771405
40Aplasia/hypoplasia of the uterus (HP:0008684)2.68388643
41Late onset (HP:0003584)2.63207879
42Abnormality of magnesium homeostasis (HP:0004921)2.63086616
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60607044
44Severe visual impairment (HP:0001141)2.56044800
45Tubulointerstitial nephritis (HP:0001970)2.49725987
46Abnormal pancreas size (HP:0012094)2.49469652
47Abnormal glucose tolerance (HP:0001952)2.47856179
48Menorrhagia (HP:0000132)2.47423943
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42072078
50Hypomagnesemia (HP:0002917)2.42017623
51Abnormality of male internal genitalia (HP:0000022)2.37261623
52Type 2 muscle fiber atrophy (HP:0003554)2.34709988
53Hypoalphalipoproteinemia (HP:0003233)2.33114633
54Nausea (HP:0002018)2.29051979
55Mitral stenosis (HP:0001718)2.28948252
56Abnormality of polysaccharide metabolism (HP:0011012)2.23310113
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23310113
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23310113
59Urinary glycosaminoglycan excretion (HP:0003541)2.23277113
60Mucopolysacchariduria (HP:0008155)2.23277113
61Muscle fiber atrophy (HP:0100295)2.22266058
62Pancreatitis (HP:0001733)2.14135875
63Beaking of vertebral bodies (HP:0004568)2.11589613
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03554292
65Cholecystitis (HP:0001082)2.01467049
66Abnormal gallbladder physiology (HP:0012438)2.01467049
67Ectropion (HP:0000656)2.01164102
68Acute encephalopathy (HP:0006846)2.00664795
69Retinal atrophy (HP:0001105)1.98834086
70Stage 5 chronic kidney disease (HP:0003774)1.97177260
71Poikiloderma (HP:0001029)1.96206768
72Hypokinesia (HP:0002375)1.95446840
73Abnormality of nucleobase metabolism (HP:0010932)1.95171591
74Opisthotonus (HP:0002179)1.92864428
75Reduced subcutaneous adipose tissue (HP:0003758)1.92333308
76Hepatosplenomegaly (HP:0001433)1.90692703
77Male infertility (HP:0003251)1.88569036
78Tubular atrophy (HP:0000092)1.87660374
79Distal lower limb muscle weakness (HP:0009053)1.87084733
80Congenital sensorineural hearing impairment (HP:0008527)1.86721069
81Cardiomegaly (HP:0001640)1.86472437
82Petechiae (HP:0000967)1.85869690
83Severe muscular hypotonia (HP:0006829)1.83777287
84Increased purine levels (HP:0004368)1.83484054
85Hyperuricemia (HP:0002149)1.83484054
86Abnormal rod and cone electroretinograms (HP:0008323)1.83481074
87Patchy hypopigmentation of hair (HP:0011365)1.80492047
88Microretrognathia (HP:0000308)1.78915132
89Tetany (HP:0001281)1.77367213
90Adrenal hypoplasia (HP:0000835)1.76762732
91Abnormality of serine family amino acid metabolism (HP:0010894)1.76647302
92Abnormality of glycine metabolism (HP:0010895)1.76647302
93Increased serum ferritin (HP:0003281)1.75974548
94Joint swelling (HP:0001386)1.73511334
95Vertebral compression fractures (HP:0002953)1.73026378
96Bicornuate uterus (HP:0000813)1.72089663
97Progressive neurologic deterioration (HP:0002344)1.71705275
98Zonular cataract (HP:0010920)1.70314017
99Acute necrotizing encephalopathy (HP:0006965)1.69744897
100Hyperglycinuria (HP:0003108)1.69428877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.07517316
2PIK3CG5.83849874
3MAP3K124.77177152
4EPHA24.21476167
5TESK24.18645440
6BCKDK3.40222854
7MYLK2.74511951
8BLK2.48477711
9TXK1.97709802
10MST41.86411293
11VRK21.62825334
12ARAF1.58984833
13NME11.57696322
14NME21.53436340
15PIM21.51863594
16DAPK11.46908694
17CASK1.44453607
18NEK11.38557802
19LMTK21.38237956
20ZAP701.32458153
21ABL21.25186878
22RIPK11.24912193
23MST1R1.24270819
24MAP3K31.23858898
25KDR1.20371392
26BCR1.18434909
27PAK41.17369129
28SIK31.10764421
29MET0.98631106
30TESK10.97665736
31LIMK10.93593919
32GRK60.89456217
33PTK20.87652664
34DAPK30.85628591
35PBK0.85420177
36PRKCE0.84156172
37GRK50.83125882
38TRIM280.82854238
39CDK190.80725131
40SCYL20.75510364
41ERN10.74759601
42TNIK0.73635066
43MAP3K20.73588128
44CSF1R0.71998399
45STK100.65854515
46BMPR1B0.65440405
47CSNK1G20.64622452
48ADRBK20.63349081
49TLK10.62890019
50LRRK20.60238984
51BUB10.60058003
52GRK10.58794758
53PTK2B0.57905957
54PHKG20.57514126
55PHKG10.57514126
56DAPK20.57367895
57CSNK1G30.55251697
58OXSR10.55115850
59EIF2AK10.54151658
60ILK0.52838307
61PRKCI0.51597077
62MAP2K60.48815133
63TGFBR20.48662676
64ACVR1B0.47980317
65NUAK10.47512310
66WNK40.45376245
67RPS6KA40.43481818
68PINK10.43116224
69PRKCQ0.42727218
70CSNK1A1L0.41981069
71WNK30.41071914
72MAPKAPK30.41001145
73STK240.39526013
74TRPM70.38078609
75ERBB40.36625198
76MAPK110.36505462
77FLT30.35746279
78IKBKB0.35485808
79ERBB30.35280788
80GRK70.35271584
81VRK10.34983829
82CSNK1G10.32497300
83CAMK2G0.32240950
84PRKACB0.31941563
85EGFR0.30606244
86EPHB10.28717110
87RPS6KA50.27144223
88CCNB10.26505786
89ABL10.26503815
90HIPK20.25912955
91EPHB20.25883569
92TAF10.25524028
93ITK0.25291272
94MARK30.22583250
95MAP3K90.22461980
96TBK10.21669709
97ROCK10.20533163
98PAK10.20225099
99AKT20.20208725
100PRKCA0.18607006

Predicted pathways (KEGG)

RankGene SetZ-score
1Galactose metabolism_Homo sapiens_hsa000524.10228133
2Asthma_Homo sapiens_hsa053104.00719458
3Vitamin digestion and absorption_Homo sapiens_hsa049773.93282613
4Autoimmune thyroid disease_Homo sapiens_hsa053202.94734440
5Allograft rejection_Homo sapiens_hsa053302.81306527
6Graft-versus-host disease_Homo sapiens_hsa053322.61192024
7Nitrogen metabolism_Homo sapiens_hsa009102.50245578
8Type I diabetes mellitus_Homo sapiens_hsa049402.44248063
9Mineral absorption_Homo sapiens_hsa049782.26935668
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17194881
11Fat digestion and absorption_Homo sapiens_hsa049752.16557792
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.14824597
13Staphylococcus aureus infection_Homo sapiens_hsa051502.03378906
14Sphingolipid metabolism_Homo sapiens_hsa006002.01097490
15Fructose and mannose metabolism_Homo sapiens_hsa000511.98314544
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.76706956
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74267864
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71859317
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70686352
20Pentose phosphate pathway_Homo sapiens_hsa000301.68232214
21Oxidative phosphorylation_Homo sapiens_hsa001901.64007919
22Proteasome_Homo sapiens_hsa030501.55111563
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54722714
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53547851
25Rheumatoid arthritis_Homo sapiens_hsa053231.53474151
26Chemical carcinogenesis_Homo sapiens_hsa052041.52893373
27Fatty acid elongation_Homo sapiens_hsa000621.51654923
28Phototransduction_Homo sapiens_hsa047441.51612416
29Other glycan degradation_Homo sapiens_hsa005111.49930182
30Complement and coagulation cascades_Homo sapiens_hsa046101.45445136
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45350526
32Viral myocarditis_Homo sapiens_hsa054161.38358147
33Antigen processing and presentation_Homo sapiens_hsa046121.36350902
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35370011
35Glutathione metabolism_Homo sapiens_hsa004801.34115411
36Linoleic acid metabolism_Homo sapiens_hsa005911.33038912
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23194615
38Parkinsons disease_Homo sapiens_hsa050121.14143128
39Folate biosynthesis_Homo sapiens_hsa007901.09922638
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07686114
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.03253612
42Ether lipid metabolism_Homo sapiens_hsa005651.02565189
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02441824
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98066248
45Carbon metabolism_Homo sapiens_hsa012000.90262210
46Starch and sucrose metabolism_Homo sapiens_hsa005000.87048722
47Lysosome_Homo sapiens_hsa041420.87047412
48Homologous recombination_Homo sapiens_hsa034400.84441456
49N-Glycan biosynthesis_Homo sapiens_hsa005100.81828419
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.81528432
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79972461
52Alzheimers disease_Homo sapiens_hsa050100.77592554
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75967605
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75044364
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73764725
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.72897767
57Arachidonic acid metabolism_Homo sapiens_hsa005900.71784465
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71368639
59PPAR signaling pathway_Homo sapiens_hsa033200.70807607
60Huntingtons disease_Homo sapiens_hsa050160.70730683
61Hematopoietic cell lineage_Homo sapiens_hsa046400.70438037
62Circadian rhythm_Homo sapiens_hsa047100.70379130
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.67945133
64Leishmaniasis_Homo sapiens_hsa051400.66413226
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64770115
66Caffeine metabolism_Homo sapiens_hsa002320.63375896
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62704969
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.62539375
69Phenylalanine metabolism_Homo sapiens_hsa003600.61949071
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61146906
71Metabolic pathways_Homo sapiens_hsa011000.61114764
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60157022
73Retinol metabolism_Homo sapiens_hsa008300.56606663
74Biosynthesis of amino acids_Homo sapiens_hsa012300.55999513
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55957440
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.55810045
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51619689
78Peroxisome_Homo sapiens_hsa041460.51411934
79Cardiac muscle contraction_Homo sapiens_hsa042600.49041550
80Propanoate metabolism_Homo sapiens_hsa006400.48249346
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47778991
82Phagosome_Homo sapiens_hsa041450.45277481
83Tyrosine metabolism_Homo sapiens_hsa003500.40800589
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40167386
85Bile secretion_Homo sapiens_hsa049760.38708792
86Tryptophan metabolism_Homo sapiens_hsa003800.37758010
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37389847
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36521188
89One carbon pool by folate_Homo sapiens_hsa006700.35129615
90Pyrimidine metabolism_Homo sapiens_hsa002400.35092640
91Arginine and proline metabolism_Homo sapiens_hsa003300.34843067
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33474120
93Glycerolipid metabolism_Homo sapiens_hsa005610.31302008
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30400814
95Toxoplasmosis_Homo sapiens_hsa051450.30267150
96Tuberculosis_Homo sapiens_hsa051520.30009761
97Purine metabolism_Homo sapiens_hsa002300.27721517
98Salmonella infection_Homo sapiens_hsa051320.26557607
99Arginine biosynthesis_Homo sapiens_hsa002200.25534530
100Vibrio cholerae infection_Homo sapiens_hsa051100.25134173

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »