CST6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.99006274
2hair follicle morphogenesis (GO:0031069)7.89840414
3sphingoid metabolic process (GO:0046519)7.76335924
4molting cycle (GO:0042303)7.69982325
5hair cycle (GO:0042633)7.69982325
6regulation of water loss via skin (GO:0033561)7.61138317
7keratinization (GO:0031424)7.39834083
8bundle of His cell to Purkinje myocyte communication (GO:0086069)7.26206082
9phospholipid scrambling (GO:0017121)7.25346301
10keratinocyte proliferation (GO:0043616)7.03104628
11linoleic acid metabolic process (GO:0043651)6.44852309
12response to phenylpropanoid (GO:0080184)6.07702512
13negative regulation of cell fate specification (GO:0009996)5.99661410
14sphingosine metabolic process (GO:0006670)5.97090267
15skin morphogenesis (GO:0043589)5.89188558
16diol metabolic process (GO:0034311)5.87117985
17keratinocyte differentiation (GO:0030216)5.85636181
18intermediate filament organization (GO:0045109)5.83832163
19peptide cross-linking (GO:0018149)5.82833667
20hemidesmosome assembly (GO:0031581)5.60094222
21epidermal cell differentiation (GO:0009913)5.35398854
22positive regulation of hair cycle (GO:0042635)5.31222321
23positive regulation of hair follicle development (GO:0051798)5.31222321
24multicellular organismal water homeostasis (GO:0050891)5.15296427
25long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.13534955
26very long-chain fatty acid metabolic process (GO:0000038)5.00866973
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.89425866
28molting cycle process (GO:0022404)4.86789140
29hair cycle process (GO:0022405)4.86789140
30regulation of ruffle assembly (GO:1900027)4.86243389
31lymph vessel development (GO:0001945)4.84206485
32negative regulation of cell fate commitment (GO:0010454)4.65214512
33lipoxygenase pathway (GO:0019372)4.54220702
34fatty-acyl-CoA biosynthetic process (GO:0046949)4.47446714
35intestinal epithelial cell development (GO:0060576)4.41129536
36water homeostasis (GO:0030104)4.40181933
37regulation of cardioblast differentiation (GO:0051890)4.39774846
38regulation of apoptotic process involved in morphogenesis (GO:1902337)4.34292926
39positive regulation of keratinocyte differentiation (GO:0045618)4.31563643
40positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.28301216
41retinol metabolic process (GO:0042572)4.27275942
42cyclooxygenase pathway (GO:0019371)4.26581946
43G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.24186981
44* epidermis development (GO:0008544)4.23895054
45positive regulation of epidermal cell differentiation (GO:0045606)4.17627090
46regulation of phospholipase A2 activity (GO:0032429)4.16696892
47regulation of chemokine secretion (GO:0090196)4.13224900
48chemical homeostasis within a tissue (GO:0048875)4.00112460
49regulation of transforming growth factor beta1 production (GO:0032908)3.95714533
50negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.94366238
51positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.84451691
52negative regulation of keratinocyte proliferation (GO:0010839)3.78773011
53phosphatidylserine acyl-chain remodeling (GO:0036150)3.75119084
54positive regulation of meiotic cell cycle (GO:0051446)3.69205441
55atrioventricular valve morphogenesis (GO:0003181)3.69196729
56fatty-acyl-CoA metabolic process (GO:0035337)3.67125568
57regulation of hair follicle development (GO:0051797)3.65233589
58ectoderm development (GO:0007398)3.63161038
59negative regulation of stress fiber assembly (GO:0051497)3.62551954
60calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.60752056
61surfactant homeostasis (GO:0043129)3.57931392
62positive regulation of Rho protein signal transduction (GO:0035025)3.56375362
63regulation of heterotypic cell-cell adhesion (GO:0034114)3.52896763
64regulation of cell fate specification (GO:0042659)3.52306067
65thioester biosynthetic process (GO:0035384)3.49827668
66acyl-CoA biosynthetic process (GO:0071616)3.49827668
67intermediate filament cytoskeleton organization (GO:0045104)3.48030633
68negative regulation of kidney development (GO:0090185)3.46736463
69positive regulation of epidermis development (GO:0045684)3.46076467
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.39965885
71positive regulation of male gonad development (GO:2000020)3.37551742
72intermediate filament-based process (GO:0045103)3.35405845
73regulation of keratinocyte differentiation (GO:0045616)3.31092450
74viral transcription (GO:0019083)3.25220133
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.23416362
76fatty acid elongation (GO:0030497)3.18656835
77positive regulation of interleukin-8 secretion (GO:2000484)3.16531837
78negative regulation of smooth muscle cell differentiation (GO:0051151)3.16321727
79regulation of male gonad development (GO:2000018)3.12980539
80regulation of glomerular filtration (GO:0003093)3.08745782
81regulation of cell proliferation involved in kidney development (GO:1901722)3.08667802
82* epithelium development (GO:0060429)3.05008887
83phosphatidylinositol acyl-chain remodeling (GO:0036149)3.04768256
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.01862578
85epithelial cell differentiation involved in prostate gland development (GO:0060742)3.01495745
86keratinocyte development (GO:0003334)3.00440178
87ventricular cardiac muscle cell action potential (GO:0086005)3.00209781
88translational termination (GO:0006415)2.99219011
89regulation of monocyte differentiation (GO:0045655)2.98803192
90regulation of axon regeneration (GO:0048679)2.98214645
91regulation of neuron projection regeneration (GO:0070570)2.98214645
92primary alcohol metabolic process (GO:0034308)2.96980835
93cell communication involved in cardiac conduction (GO:0086065)2.93677632
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.93207646
95defense response to fungus (GO:0050832)2.90998661
96detection of bacterium (GO:0016045)2.86720760
97phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.85692076
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.80405142
99ribosomal small subunit biogenesis (GO:0042274)2.79869297
100gap junction assembly (GO:0016264)2.79857508
101establishment of tissue polarity (GO:0007164)2.77783408
102establishment of planar polarity (GO:0001736)2.77783408
103regulation of epidermal cell differentiation (GO:0045604)2.76735531
104positive regulation of chemokine secretion (GO:0090197)2.76721922
105regulation of hair cycle (GO:0042634)2.75818154
106phosphatidylserine metabolic process (GO:0006658)2.75264759
107regulation of interleukin-8 secretion (GO:2000482)2.73932535
108polyol transport (GO:0015791)2.72188909
109leukocyte aggregation (GO:0070486)2.72055274
110negative regulation of NF-kappaB import into nucleus (GO:0042347)2.71851084
111regulation of heart rate by cardiac conduction (GO:0086091)2.71810474
112alpha-linolenic acid metabolic process (GO:0036109)2.71180864
113G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71115352
114mesenchyme morphogenesis (GO:0072132)2.70564647
115cellular response to pH (GO:0071467)2.66629433
116regulation of epidermis development (GO:0045682)2.66419331
117epithelial cell-cell adhesion (GO:0090136)2.65253134
118regulation of mesenchymal cell apoptotic process (GO:2001053)2.65082306
119negative regulation of actin filament bundle assembly (GO:0032232)2.64967228
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.64080022
121chemosensory behavior (GO:0007635)2.63280326
122fibrinolysis (GO:0042730)2.61774448
123male sex determination (GO:0030238)2.61554610
124germ cell migration (GO:0008354)2.60182482
125centrosome localization (GO:0051642)2.58923732
126ephrin receptor signaling pathway (GO:0048013)2.56342198
127adhesion of symbiont to host cell (GO:0044650)2.55558844
128virion attachment to host cell (GO:0019062)2.55558844
129long-chain fatty acid biosynthetic process (GO:0042759)2.55469914
130regulation of transforming growth factor beta2 production (GO:0032909)2.54529363
131hair follicle development (GO:0001942)2.47058780
132triglyceride biosynthetic process (GO:0019432)2.41213556
133cell-substrate junction assembly (GO:0007044)2.40784788
134polarized epithelial cell differentiation (GO:0030859)2.39208180
135regulation of keratinocyte proliferation (GO:0010837)2.38849617
136unsaturated fatty acid biosynthetic process (GO:0006636)2.32197774
137phosphatidylcholine acyl-chain remodeling (GO:0036151)2.31782410
138skin development (GO:0043588)2.31439939
139fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30847374
140hypotonic response (GO:0006971)2.26247239
141neutral lipid biosynthetic process (GO:0046460)2.23638835
142acylglycerol biosynthetic process (GO:0046463)2.23638835
143primary alcohol catabolic process (GO:0034310)2.22144106
144adhesion of symbiont to host (GO:0044406)2.21537287
145regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.21415175
146negative regulation of interferon-gamma production (GO:0032689)2.18950244
147detection of other organism (GO:0098543)2.14060761
148lateral sprouting from an epithelium (GO:0060601)2.10250968
149hair cell differentiation (GO:0035315)2.09341570
150acyl-CoA metabolic process (GO:0006637)2.08848359
151thioester metabolic process (GO:0035383)2.08848359
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.07957959
153alditol phosphate metabolic process (GO:0052646)2.07231412
154negative regulation of stem cell proliferation (GO:2000647)2.06601195
155desmosome organization (GO:0002934)15.6284576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.81970694
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.80949111
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.73098449
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.65221124
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.64205717
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.29056055
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.25674918
8TP63_17297297_ChIP-ChIP_HaCaT_Human11.7234468
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95240396
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90144764
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90144764
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87811596
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83829856
14TP53_18474530_ChIP-ChIP_U2OS_Human1.80316015
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.77808903
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.74550796
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72586899
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72586899
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72586899
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72210103
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63651530
22* SOX2_20726797_ChIP-Seq_SW620_Human1.61882171
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.59420077
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.59078266
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.55393776
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54146893
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52109648
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.51086511
29AR_21572438_ChIP-Seq_LNCaP_Human1.42900579
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42886719
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42386786
32* UBF1/2_26484160_Chip-Seq_HMECs_Human1.41305477
33CTCF_20526341_ChIP-Seq_ESCs_Human1.41048991
34TP63_23658742_ChIP-Seq_EP156T_Human1.40316355
35TP53_16413492_ChIP-PET_HCT116_Human1.39577628
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37866531
37ZNF263_19887448_ChIP-Seq_K562_Human1.37360671
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37223427
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36554881
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36554881
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32414903
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.32337060
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31737633
44CLOCK_20551151_ChIP-Seq_293T_Human1.27614352
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26293975
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25488248
47* BCOR_27268052_Chip-Seq_Bcells_Human1.25255293
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.25197647
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24550529
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24211748
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.23190095
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21238037
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20972590
54CJUN_26792858_Chip-Seq_BT549_Human1.20746688
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.19791829
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.18538230
57KLF5_25053715_ChIP-Seq_YYC3_Human1.16882601
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16303459
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14948231
60BCL6_27268052_Chip-Seq_Bcells_Human1.14931444
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14429776
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13570799
63AHR_22903824_ChIP-Seq_MCF-7_Human1.11911628
64CSB_26484114_Chip-Seq_FIBROBLAST_Human1.11788653
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11772306
66E2F1_20622854_ChIP-Seq_HELA_Human1.11464567
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11171316
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.09751442
69RXR_22108803_ChIP-Seq_LS180_Human1.09323481
70* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09202310
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09181505
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08382034
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08361068
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08344385
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08270909
76CTCF_27219007_Chip-Seq_Bcells_Human1.05966315
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.05772092
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05575261
79GATA4_25053715_ChIP-Seq_YYC3_Human1.05134877
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04965070
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04780057
82* ATF3_27146783_Chip-Seq_COLON_Human1.03927391
83* P68_20966046_ChIP-Seq_HELA_Human1.03427480
84SMC4_20622854_ChIP-Seq_HELA_Human1.02457206
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02275588
86* LXR_22292898_ChIP-Seq_THP-1_Human1.01797334
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01459454
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00955505
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00737912
90* RACK7_27058665_Chip-Seq_MCF-7_Human0.99003477
91SA1_27219007_Chip-Seq_ERYTHROID_Human0.98805000
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.97410260
93* ERG_20517297_ChIP-Seq_VCAP_Human0.97338686
94SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97086617
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96667197
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95976867
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95563983
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95175589
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94685465
100BCAT_22108803_ChIP-Seq_LS180_Human0.93978305
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93841185
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90827098
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.90333206
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.89967930
105CBX2_27304074_Chip-Seq_ESCs_Mouse0.89930735
106* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89715265
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.89453465
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.89453465
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89286752
110* TP63_22573176_ChIP-Seq_HFKS_Human0.88921613
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88563923
112* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87262826
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86570503
114TCF4_22108803_ChIP-Seq_LS180_Human0.83491940
115* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83254711
116GATA6_25053715_ChIP-Seq_YYC3_Human0.82207733
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81016385
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80226557
119* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79876804
120* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79876804
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79688209
122GATA6_21074721_ChIP-Seq_CACO-2_Human0.79505466
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.79390164
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.79214055
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78615014
126RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77633051
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.77418967
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77377609
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76175600
130* GATA3_24758297_ChIP-Seq_MCF-7_Human0.76046474
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75704218
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74599855
133VDR_22108803_ChIP-Seq_LS180_Human0.74277382
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73327371
135FOXH1_21741376_ChIP-Seq_ESCs_Human0.72799835
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72589118
137KAP1_27257070_Chip-Seq_ESCs_Mouse0.72366846
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71350929
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70037848
140GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69840167
141TAF2_19829295_ChIP-Seq_ESCs_Human0.69726781
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.69126576
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68471243
144P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67132120
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.67041763
146* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66165335
147EGR1_19032775_ChIP-ChIP_M12_Human0.64780105
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.61233640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.96119546
2MP0010234_abnormal_vibrissa_follicle5.71859856
3MP0004381_abnormal_hair_follicle5.45859494
4MP0005275_abnormal_skin_tensile5.43964576
5MP0005501_abnormal_skin_physiology4.87832576
6MP0003941_abnormal_skin_development4.11145513
7MP0002098_abnormal_vibrissa_morphology3.69009064
8MP0002009_preneoplasia3.66071705
9MP0000579_abnormal_nail_morphology3.45073908
10MP0003705_abnormal_hypodermis_morpholog2.99604471
11* MP0001216_abnormal_epidermal_layer2.83715397
12* MP0000377_abnormal_hair_follicle2.72748007
13* MP0010771_integument_phenotype2.72187279
14* MP0002060_abnormal_skin_morphology2.68671294
15MP0004947_skin_inflammation2.58989416
16MP0000427_abnormal_hair_cycle2.40114396
17* MP0000647_abnormal_sebaceous_gland2.30310607
18MP0003011_delayed_dark_adaptation2.23897951
19MP0010678_abnormal_skin_adnexa2.22690661
20MP0002249_abnormal_larynx_morphology2.19403387
21MP0005451_abnormal_body_composition2.18895566
22MP0003878_abnormal_ear_physiology2.09667899
23MP0005377_hearing/vestibular/ear_phenot2.09667899
24MP0002095_abnormal_skin_pigmentation1.96217907
25MP0001188_hyperpigmentation1.94712285
26MP0000537_abnormal_urethra_morphology1.92550819
27* MP0003453_abnormal_keratinocyte_physiol1.91160915
28MP0001851_eye_inflammation1.76149923
29MP0001346_abnormal_lacrimal_gland1.71053104
30MP0002254_reproductive_system_inflammat1.64073544
31MP0005409_darkened_coat_color1.62082857
32MP0000467_abnormal_esophagus_morphology1.54861049
33MP0000762_abnormal_tongue_morphology1.52638711
34MP0000516_abnormal_urinary_system1.51048753
35MP0005367_renal/urinary_system_phenotyp1.51048753
36MP0003315_abnormal_perineum_morphology1.50258625
37MP0003566_abnormal_cell_adhesion1.48068210
38MP0000015_abnormal_ear_pigmentation1.44923002
39MP0002234_abnormal_pharynx_morphology1.37815371
40* MP0009931_abnormal_skin_appearance1.35909362
41* MP0000367_abnormal_coat/_hair1.34893327
42MP0000383_abnormal_hair_follicle1.28477345
43* MP0001243_abnormal_dermal_layer1.28201675
44MP0010386_abnormal_urinary_bladder1.23672222
45MP0002006_tumorigenesis1.12661141
46MP0002282_abnormal_trachea_morphology1.12439178
47MP0005174_abnormal_tail_pigmentation1.12266709
48MP0010030_abnormal_orbit_morphology1.11036321
49MP0004019_abnormal_vitamin_homeostasis1.10892895
50MP0003300_gastrointestinal_ulcer1.09903469
51MP0005023_abnormal_wound_healing1.04831001
52MP0009384_cardiac_valve_regurgitation1.04217086
53MP0009379_abnormal_foot_pigmentation1.03652780
54MP0003136_yellow_coat_color1.02939937
55MP0001340_abnormal_eyelid_morphology1.02311323
56MP0009780_abnormal_chondrocyte_physiolo1.00643825
57MP0009053_abnormal_anal_canal1.00494875
58MP0002166_altered_tumor_susceptibility0.97755589
59MP0002877_abnormal_melanocyte_morpholog0.95679848
60MP0005187_abnormal_penis_morphology0.93633555
61* MP0001191_abnormal_skin_condition0.93149397
62MP0004782_abnormal_surfactant_physiolog0.87045494
63MP0004272_abnormal_basement_membrane0.86721583
64MP0004264_abnormal_extraembryonic_tissu0.86431549
65MP0005085_abnormal_gallbladder_physiolo0.85251429
66MP0005623_abnormal_meninges_morphology0.83431042
67MP0010368_abnormal_lymphatic_system0.83181107
68MP0003448_altered_tumor_morphology0.82490523
69MP0003191_abnormal_cellular_cholesterol0.76832361
70MP0003195_calcinosis0.76062840
71MP0005647_abnormal_sex_gland0.72991143
72MP0005508_abnormal_skeleton_morphology0.70998748
73MP0001542_abnormal_bone_strength0.67138541
74MP0000049_abnormal_middle_ear0.62485265
75MP0002697_abnormal_eye_size0.59599979
76MP0004885_abnormal_endolymph0.59534506
77MP0002233_abnormal_nose_morphology0.58354314
78MP0004147_increased_porphyrin_level0.58292470
79MP0005075_abnormal_melanosome_morpholog0.56817241
80MP0005076_abnormal_cell_differentiation0.55797115
81MP0009250_abnormal_appendicular_skeleto0.55236169
82MP0000858_altered_metastatic_potential0.54462932
83MP0000678_abnormal_parathyroid_gland0.52181042
84MP0002277_abnormal_respiratory_mucosa0.49072822
85MP0001661_extended_life_span0.47858193
86MP0003329_amyloid_beta_deposits0.47379867
87MP0004858_abnormal_nervous_system0.46677538
88MP0001919_abnormal_reproductive_system0.45963860
89MP0000566_synostosis0.45656276
90MP0010352_gastrointestinal_tract_polyps0.45552825
91MP0003724_increased_susceptibility_to0.42649671
92MP0003763_abnormal_thymus_physiology0.41711491
93MP0001784_abnormal_fluid_regulation0.41253601
94MP0003638_abnormal_response/metabolism_0.40628876
95MP0005390_skeleton_phenotype0.39268774
96MP0001958_emphysema0.39097070
97MP0002177_abnormal_outer_ear0.38863887
98MP0000627_abnormal_mammary_gland0.38572584
99MP0008438_abnormal_cutaneous_collagen0.38538501
100MP0005257_abnormal_intraocular_pressure0.38423122
101MP0003755_abnormal_palate_morphology0.38247159
102MP0000538_abnormal_urinary_bladder0.36386639
103MP0002970_abnormal_white_adipose0.35863375
104MP0002896_abnormal_bone_mineralization0.34781820
105MP0003795_abnormal_bone_structure0.34316874
106MP0002163_abnormal_gland_morphology0.33123578
107MP0001177_atelectasis0.33046536
108MP0003806_abnormal_nucleotide_metabolis0.32223218
109MP0009046_muscle_twitch0.32071422
110MP0003936_abnormal_reproductive_system0.32034456
111MP0003950_abnormal_plasma_membrane0.31047502
112MP0003880_abnormal_central_pattern0.30939465
113MP0002998_abnormal_bone_remodeling0.30666395
114MP0002971_abnormal_brown_adipose0.30135904
115MP0000465_gastrointestinal_hemorrhage0.29925853
116MP0001849_ear_inflammation0.29575385
117MP0001984_abnormal_olfaction0.29503776
118MP0001853_heart_inflammation0.28435394
119MP0000685_abnormal_immune_system0.27800138
120MP0001286_abnormal_eye_development0.27053246
121MP0002295_abnormal_pulmonary_circulatio0.26133756
122MP0001299_abnormal_eye_distance/0.25602261
123MP0002168_other_aberrant_phenotype0.25393123
124MP0005165_increased_susceptibility_to0.24180947
125MP0002111_abnormal_tail_morphology0.24046387
126MP0005503_abnormal_tendon_morphology0.23708743
127MP0004185_abnormal_adipocyte_glucose0.23648575
128MP0001186_pigmentation_phenotype0.23405457
129MP0002822_catalepsy0.22910371
130MP0000003_abnormal_adipose_tissue0.22647427
131MP0000681_abnormal_thyroid_gland0.21632797
132MP0008260_abnormal_autophagy0.21165476
133MP0001881_abnormal_mammary_gland0.20962902
134MP0005193_abnormal_anterior_eye0.20358424
135MP0000750_abnormal_muscle_regeneration0.19173252
136MP0003075_altered_response_to0.17872492
137MP0005197_abnormal_uvea_morphology0.16395898
138MP0005330_cardiomyopathy0.16301894
139MP0005248_abnormal_Harderian_gland0.15928469
140MP0005058_abnormal_lysosome_morphology0.14053804
141MP0006138_congestive_heart_failure0.13235675
142MP0000372_irregular_coat_pigmentation0.11684450
143MP0000462_abnormal_digestive_system0.11371993
144MP0002148_abnormal_hypersensitivity_rea0.10172981

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)9.11213683
2Right ventricular cardiomyopathy (HP:0011663)7.57866652
3Increased IgE level (HP:0003212)7.40381832
4Abnormal hair laboratory examination (HP:0003328)7.19449681
5Parakeratosis (HP:0001036)7.18562714
6Woolly hair (HP:0002224)6.39697971
7Slow-growing hair (HP:0002217)6.33733476
8Abnormality of hair growth rate (HP:0011363)6.33733476
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.25732402
10Congenital ichthyosiform erythroderma (HP:0007431)6.05994790
11Abnormality of nail color (HP:0100643)5.90230616
12Erythema (HP:0010783)5.07997954
13Absent eyelashes (HP:0000561)4.99671730
14Alopecia of scalp (HP:0002293)4.96476515
15Palmoplantar hyperkeratosis (HP:0000972)4.78833119
16Thick nail (HP:0001805)4.77067800
17Natal tooth (HP:0000695)4.77039776
18Onycholysis (HP:0001806)4.71049911
19Erythroderma (HP:0001019)4.54786878
20Palmar hyperkeratosis (HP:0010765)4.47068484
21Oligodontia (HP:0000677)4.40410903
22Asymmetry of the thorax (HP:0001555)4.35291060
23Reticulocytopenia (HP:0001896)4.34860911
24Plantar hyperkeratosis (HP:0007556)4.20548891
25Advanced eruption of teeth (HP:0006288)4.15778748
26Ventricular tachycardia (HP:0004756)4.15657659
27Curly hair (HP:0002212)3.84721541
28Acanthosis nigricans (HP:0000956)3.73679912
29Abnormality of the axillary hair (HP:0100134)3.64210379
30Abnormality of secondary sexual hair (HP:0009888)3.64210379
31Sparse eyelashes (HP:0000653)3.62958026
32Hyporeflexia of lower limbs (HP:0002600)3.57233322
33Absent eyebrow (HP:0002223)3.50493255
34Abnormal sex determination (HP:0012244)3.46283541
35Sex reversal (HP:0012245)3.46283541
36Lip pit (HP:0100267)3.30292370
37Follicular hyperkeratosis (HP:0007502)3.22942793
38Abnormal blistering of the skin (HP:0008066)3.22205023
39Fine hair (HP:0002213)3.21169814
40Fragile nails (HP:0001808)3.15197691
41Double outlet right ventricle (HP:0001719)3.14364650
42Congenital malformation of the right heart (HP:0011723)3.14364650
43Sparse scalp hair (HP:0002209)3.09190539
44Hamartoma of the eye (HP:0010568)3.04486384
45Nail dystrophy (HP:0008404)2.85336699
46Ulnar claw (HP:0001178)2.81102871
47Ventricular fibrillation (HP:0001663)2.79553221
48Oral leukoplakia (HP:0002745)2.72814927
49Epidermoid cyst (HP:0200040)2.69990897
50Brittle hair (HP:0002299)2.69929696
51Milia (HP:0001056)2.68694643
52Hypohidrosis (HP:0000966)2.65230491
53Bifid scrotum (HP:0000048)2.56739260
54Dry hair (HP:0011359)2.56202316
55Distal lower limb muscle weakness (HP:0009053)2.55299365
56Breast hypoplasia (HP:0003187)2.53739432
57Ureteral duplication (HP:0000073)2.51807879
58Hypoplastic nipples (HP:0002557)2.50211733
59Sudden death (HP:0001699)2.46475492
60Ridged nail (HP:0001807)2.45984743
61Hypoplasia of the iris (HP:0007676)2.45216895
62Corneal erosion (HP:0200020)2.43043362
63Palmoplantar keratoderma (HP:0000982)2.41439642
64Pruritus (HP:0000989)2.41339602
65Duplicated collecting system (HP:0000081)2.40921444
66Corneal dystrophy (HP:0001131)2.40918851
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.40337913
68Popliteal pterygium (HP:0009756)2.39516867
69Pili torti (HP:0003777)2.36036149
70Ectropion (HP:0000656)2.34314801
71Palpebral edema (HP:0100540)2.33549972
72Hypergammaglobulinemia (HP:0010702)2.30083032
73Areflexia of lower limbs (HP:0002522)2.26632645
74Gangrene (HP:0100758)2.24644555
75Abnormality of the gastric mucosa (HP:0004295)2.22629617
76Concave nail (HP:0001598)2.18454197
77Anhidrosis (HP:0000970)2.15833999
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11527304
79Abnormal hemoglobin (HP:0011902)2.10292479
80Blepharitis (HP:0000498)2.09413020
81Abnormality of the salivary glands (HP:0010286)2.08675360
82Testicular atrophy (HP:0000029)2.06510881
83Abnormality of the pupil (HP:0000615)2.05970646
84Selective tooth agenesis (HP:0001592)2.02590206
85Abnormality of the renal collecting system (HP:0004742)1.97328641
86Bilateral sensorineural hearing impairment (HP:0008619)1.95481036
87Hoarse voice (HP:0001609)1.94679857
88Pustule (HP:0200039)1.90123195
89Upper limb muscle weakness (HP:0003484)1.87949593
90Conjunctival hamartoma (HP:0100780)1.87105845
91Down-sloping shoulders (HP:0200021)1.85452332
92Prostate neoplasm (HP:0100787)1.85060245
93Abnormality of cells of the erythroid lineage (HP:0012130)1.81554160
94Absent hair (HP:0002298)1.80944021
95Aplasia cutis congenita (HP:0001057)1.79831651
96Vascular calcification (HP:0004934)1.79372888
97Calf muscle hypertrophy (HP:0008981)1.79116078
98Abnormality of permanent molar morphology (HP:0011071)1.79004964
99Abnormality of the dental root (HP:0006486)1.79004964
100Taurodontia (HP:0000679)1.79004964
101Keratoconus (HP:0000563)1.78555611
102Increased corneal curvature (HP:0100692)1.78555611
103Dehydration (HP:0001944)1.78075019
104Abnormality of the aortic arch (HP:0012303)1.76648367
105Hyperhidrosis (HP:0000975)1.74741122
106Stenosis of the external auditory canal (HP:0000402)1.74157237
107Villous atrophy (HP:0011473)1.74132052
108Abnormality of small intestinal villus morphology (HP:0011472)1.74132052
109Trismus (HP:0000211)1.72771312
110Obstructive sleep apnea (HP:0002870)1.72542497
111Tubulointerstitial fibrosis (HP:0005576)1.72284822
112Dry skin (HP:0000958)1.71460812
113Neonatal death (HP:0003811)1.69919239
114Testicular neoplasm (HP:0010788)1.69663012
115Eczematoid dermatitis (HP:0000976)1.69271474
116Wide anterior fontanel (HP:0000260)1.69220990
117Pallor (HP:0000980)1.66752824
118Abnormality of molar (HP:0011077)1.65476127
119Abnormality of molar morphology (HP:0011070)1.65476127
120Cardiovascular calcification (HP:0011915)1.64729348
121Coarse hair (HP:0002208)1.63915102
122Pterygium (HP:0001059)1.63480141
123Congenital, generalized hypertrichosis (HP:0004540)1.62368225
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.61166552
125Osteolytic defects of the hand bones (HP:0009699)1.61166552
126Abnormality of the dental pulp (HP:0006479)1.60345181
127Muscle hypertrophy of the lower extremities (HP:0008968)1.59871834
128Laryngomalacia (HP:0001601)1.59604192
129Aplasia of the phalanges of the hand (HP:0009802)1.59276456
130Aplasia involving bones of the extremities (HP:0009825)1.59276456
131Aplasia involving bones of the upper limbs (HP:0009823)1.59276456
132Fatigable weakness (HP:0003473)1.57552940
133Abnormality of the neuromuscular junction (HP:0003398)1.57552940
134Amniotic constriction ring (HP:0009775)1.52123228
135Abnormality of placental membranes (HP:0011409)1.52123228
136Nasolacrimal duct obstruction (HP:0000579)1.47918576
137Furrowed tongue (HP:0000221)1.46058432
138Skin ulcer (HP:0200042)1.44890616
139Urticaria (HP:0001025)1.43200889
140Hypoplastic labia majora (HP:0000059)1.41291047
141Short nail (HP:0001799)1.41191963
142Melanocytic nevus (HP:0000995)1.41016497
143Conical tooth (HP:0000698)1.39026411
144Multifactorial inheritance (HP:0001426)1.35522703
145Split foot (HP:0001839)1.35224680
146Septate vagina (HP:0001153)1.33525155
147Abnormality of the distal phalanges of the toes (HP:0010182)1.32522434
148Hamartoma (HP:0010566)1.29931381
149Seborrheic dermatitis (HP:0001051)1.29744859
150Abnormality of the labia majora (HP:0012881)1.28209943
151Xerostomia (HP:0000217)1.26576719
152Anonychia (HP:0001798)1.24504794
153Carious teeth (HP:0000670)1.23569321
154Abnormality of the fingernails (HP:0001231)1.23446887
155Atrophic scars (HP:0001075)1.22588780
156Lack of skin elasticity (HP:0100679)1.18908015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.87461153
2MST46.75303053
3EPHB26.01740587
4MAPKAPK34.44646451
5FER4.30557784
6BCR3.64304764
7MAP3K122.99853664
8NME22.86530145
9RPS6KB22.81131155
10TRPM72.56347318
11LRRK22.52361585
12MAP3K62.50896896
13STK242.49255591
14EPHA42.41152675
15LATS12.16052538
16MAP3K22.10965766
17STK102.02199099
18CDK121.98415668
19TGFBR11.96409751
20RIPK41.91854679
21RIPK11.88666826
22TNK21.86344262
23ERBB31.83952896
24LMTK21.81372243
25TESK21.77864208
26SMG11.77085271
27MAP3K31.76184153
28MYLK1.74489444
29PAK41.73717857
30EEF2K1.62106451
31PTK21.58492622
32MAP2K21.46939284
33CASK1.43883413
34FGFR11.43012323
35PTK61.37543507
36MAP3K141.31461553
37VRK21.15345996
38DYRK1B1.14779658
39BMPR21.12706723
40MAPKAPK51.11119594
41TAOK11.08076310
42MST1R1.06425055
43PIM21.05820548
44TBK10.96528234
45BLK0.93446955
46IRAK30.93111107
47GRK10.92705985
48PRPF4B0.91038497
49PIK3CG0.90762703
50PKN10.89728917
51ERBB40.86644202
52ILK0.86271596
53EPHA30.84073669
54AURKA0.83963817
55BUB10.83724206
56STK38L0.83345460
57ARAF0.82870050
58MAP2K60.80988009
59LIMK10.74849958
60IKBKB0.74387856
61IKBKE0.72894980
62PRKCI0.71443821
63MAP3K10.71199389
64ERN10.69463480
65RPS6KA10.67628494
66TNIK0.66843295
67TAOK20.66564772
68TESK10.66184973
69NME10.65959496
70ADRBK10.65662345
71SIK10.65235175
72MAPKAPK20.63016636
73CDK190.61462313
74PRKCE0.61334579
75DYRK1A0.60789477
76ACVR1B0.59406338
77FGFR30.59086282
78CDK50.58614699
79ROCK10.55779323
80BRD40.54564550
81STK380.54498482
82NTRK10.53775669
83ROCK20.53432178
84MAP2K10.53171110
85CDK70.52860296
86ITK0.52810835
87EIF2AK10.50475658
88PRKD10.50290375
89MAPK150.49509355
90MAPK40.48711899
91CDK90.47182700
92EIF2AK20.47109190
93TGFBR20.45433923
94ERBB20.42846787
95MAPK30.41738061
96STK30.41444185
97DAPK30.40984383
98PDGFRA0.39845701
99STK110.39325720
100MOS0.38030294
101TTN0.37512919
102PAK30.36840896
103LATS20.36737476
104GSK3A0.36672697
105CSNK1D0.36046373
106EGFR0.35574069
107OXSR10.34871957
108DYRK30.34649831
109PRKD20.32636717
110PRKCQ0.32054987
111DAPK10.31902001
112KSR20.31634984
113PRKCD0.28758030
114ABL10.28646450
115MAP3K80.27915374
116SCYL20.27141678
117MTOR0.27074645
118MAPK90.26527106
119STK390.26349747
120PRKCZ0.26207752
121TAF10.26087981
122ABL20.25891966
123AURKB0.25771399
124PRKCA0.25508525
125CDK60.25396148
126NEK10.25189457
127PIM10.24904009
128PRKACA0.24784927
129EPHB10.23859481
130PRKG10.23555547
131MELK0.23150082
132MAPK70.22483666
133PRKACG0.22205255
134OBSCN0.22049825
135MAPK120.21768138
136BMX0.21346944
137MET0.20797063
138FYN0.20672633
139RPS6KA20.20644950
140PRKCB0.20326262
141MAP3K50.20081416
142SRC0.19908057
143HIPK20.19192235
144MARK20.18791360
145TEC0.18127336
146MAP3K110.17786037
147HCK0.17681754
148CAMK2G0.17566769
149PAK10.17549224
150CSNK1A1L0.16937431
151CAMK2A0.16004494
152CHUK0.15961272
153PBK0.15899881

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.39466035
2Sphingolipid metabolism_Homo sapiens_hsa006003.31702087
3Linoleic acid metabolism_Homo sapiens_hsa005913.24101229
4Collecting duct acid secretion_Homo sapiens_hsa049663.23340036
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09675178
6Ribosome_Homo sapiens_hsa030102.36227417
7Proteasome_Homo sapiens_hsa030502.18314753
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.06784802
9Phenylalanine metabolism_Homo sapiens_hsa003602.04190997
10Ether lipid metabolism_Homo sapiens_hsa005651.82175113
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66869029
12Vibrio cholerae infection_Homo sapiens_hsa051101.64915705
13Fatty acid elongation_Homo sapiens_hsa000621.63520851
14Axon guidance_Homo sapiens_hsa043601.62558356
15Melanogenesis_Homo sapiens_hsa049161.62078273
16Tight junction_Homo sapiens_hsa045301.60250781
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.58192591
18Arachidonic acid metabolism_Homo sapiens_hsa005901.54945577
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53515419
20Retinol metabolism_Homo sapiens_hsa008301.52995019
21Gastric acid secretion_Homo sapiens_hsa049711.45751686
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40525922
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39128199
24Fatty acid metabolism_Homo sapiens_hsa012121.38077716
25Fat digestion and absorption_Homo sapiens_hsa049751.35254048
26Chemical carcinogenesis_Homo sapiens_hsa052041.32088851
27Sphingolipid signaling pathway_Homo sapiens_hsa040711.30955281
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26674967
29Histidine metabolism_Homo sapiens_hsa003401.21981124
30Mineral absorption_Homo sapiens_hsa049781.21759926
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20808791
32Tyrosine metabolism_Homo sapiens_hsa003501.19525370
33Renin secretion_Homo sapiens_hsa049241.18324112
34Phototransduction_Homo sapiens_hsa047441.15270349
35Pertussis_Homo sapiens_hsa051331.11720102
36Cocaine addiction_Homo sapiens_hsa050301.08324864
37ErbB signaling pathway_Homo sapiens_hsa040121.06585355
38Amphetamine addiction_Homo sapiens_hsa050311.06557208
39beta-Alanine metabolism_Homo sapiens_hsa004101.06348474
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03741646
41Basal cell carcinoma_Homo sapiens_hsa052171.01719835
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01200904
43Synaptic vesicle cycle_Homo sapiens_hsa047211.00057792
44Hepatitis C_Homo sapiens_hsa051600.93987897
45Pancreatic secretion_Homo sapiens_hsa049720.93985156
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93018349
47Adherens junction_Homo sapiens_hsa045200.92948328
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92937116
49VEGF signaling pathway_Homo sapiens_hsa043700.91558498
50Fatty acid biosynthesis_Homo sapiens_hsa000610.90488264
51Estrogen signaling pathway_Homo sapiens_hsa049150.89563705
52GnRH signaling pathway_Homo sapiens_hsa049120.88252958
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86080448
54Rheumatoid arthritis_Homo sapiens_hsa053230.85911842
55Proteoglycans in cancer_Homo sapiens_hsa052050.85258576
56Long-term potentiation_Homo sapiens_hsa047200.84835505
57Hippo signaling pathway_Homo sapiens_hsa043900.84152250
58Other glycan degradation_Homo sapiens_hsa005110.83646040
59ABC transporters_Homo sapiens_hsa020100.81338111
60Ras signaling pathway_Homo sapiens_hsa040140.79039166
61Long-term depression_Homo sapiens_hsa047300.78878810
62Ovarian steroidogenesis_Homo sapiens_hsa049130.78446265
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78027525
64Serotonergic synapse_Homo sapiens_hsa047260.77952843
65Glioma_Homo sapiens_hsa052140.77665330
66Bladder cancer_Homo sapiens_hsa052190.75917191
67Phagosome_Homo sapiens_hsa041450.74567254
68Dorso-ventral axis formation_Homo sapiens_hsa043200.74469764
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.73195139
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.73064988
71Fatty acid degradation_Homo sapiens_hsa000710.72549085
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72528538
73Focal adhesion_Homo sapiens_hsa045100.71918103
74TGF-beta signaling pathway_Homo sapiens_hsa043500.69643136
75PPAR signaling pathway_Homo sapiens_hsa033200.69425173
76Rap1 signaling pathway_Homo sapiens_hsa040150.68545138
77Shigellosis_Homo sapiens_hsa051310.67887499
78Olfactory transduction_Homo sapiens_hsa047400.67840917
79Salivary secretion_Homo sapiens_hsa049700.66902453
80MicroRNAs in cancer_Homo sapiens_hsa052060.66858462
81Glutathione metabolism_Homo sapiens_hsa004800.66818373
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64836816
83Circadian entrainment_Homo sapiens_hsa047130.64046572
84Staphylococcus aureus infection_Homo sapiens_hsa051500.63292841
85Pentose phosphate pathway_Homo sapiens_hsa000300.63063078
86Salmonella infection_Homo sapiens_hsa051320.62172597
87Oxytocin signaling pathway_Homo sapiens_hsa049210.61279986
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61048575
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61012161
90Endocytosis_Homo sapiens_hsa041440.60196526
91Acute myeloid leukemia_Homo sapiens_hsa052210.59921627
92Thyroid cancer_Homo sapiens_hsa052160.57987486
93cAMP signaling pathway_Homo sapiens_hsa040240.57582393
94Wnt signaling pathway_Homo sapiens_hsa043100.57500558
95Small cell lung cancer_Homo sapiens_hsa052220.55953510
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55807249
97Prostate cancer_Homo sapiens_hsa052150.55584005
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55319119
99Glycerolipid metabolism_Homo sapiens_hsa005610.55123605
100Cholinergic synapse_Homo sapiens_hsa047250.54817614
101Dopaminergic synapse_Homo sapiens_hsa047280.52306661
102Glutamatergic synapse_Homo sapiens_hsa047240.51203894
103Lysosome_Homo sapiens_hsa041420.50479036
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50308033
105Circadian rhythm_Homo sapiens_hsa047100.50115645
106Galactose metabolism_Homo sapiens_hsa000520.49302853
107p53 signaling pathway_Homo sapiens_hsa041150.47549266
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47538206
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47207142
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46224290
111ECM-receptor interaction_Homo sapiens_hsa045120.45985302
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.44237400
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44052569
114Apoptosis_Homo sapiens_hsa042100.43655114
115Complement and coagulation cascades_Homo sapiens_hsa046100.43499687
116Vitamin digestion and absorption_Homo sapiens_hsa049770.43416882
117Steroid biosynthesis_Homo sapiens_hsa001000.43318836
118Sulfur relay system_Homo sapiens_hsa041220.43315488
119Oxidative phosphorylation_Homo sapiens_hsa001900.42887925
120Amoebiasis_Homo sapiens_hsa051460.42311027
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41485728
122Pyruvate metabolism_Homo sapiens_hsa006200.41387952
123Gap junction_Homo sapiens_hsa045400.40850555
124Notch signaling pathway_Homo sapiens_hsa043300.40243309
125Alzheimers disease_Homo sapiens_hsa050100.39853534
126Calcium signaling pathway_Homo sapiens_hsa040200.39289055
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39059076
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36792546
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36170376
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34245220
131Fructose and mannose metabolism_Homo sapiens_hsa000510.30463207
132Peroxisome_Homo sapiens_hsa041460.29548517
133Tuberculosis_Homo sapiens_hsa051520.29211757
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28072283
135Renin-angiotensin system_Homo sapiens_hsa046140.20501006
136Malaria_Homo sapiens_hsa051440.18747432
137Insulin signaling pathway_Homo sapiens_hsa049100.17456198
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16909562
139Carbon metabolism_Homo sapiens_hsa012000.16571734

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