CST7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.39345605
2cytidine metabolic process (GO:0046087)8.39345605
3cytidine catabolic process (GO:0006216)8.39345605
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.58810223
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.23083104
6regulation of activation of Janus kinase activity (GO:0010533)5.46956672
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.17163549
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.17163549
9negative regulation of phagocytosis (GO:0050765)5.09859927
10DNA deamination (GO:0045006)5.00502386
11ribosomal small subunit assembly (GO:0000028)4.81652569
12regulation of regulatory T cell differentiation (GO:0045589)4.79134091
13regulation of natural killer cell mediated immunity (GO:0002715)4.73265505
14regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.73265505
15eosinophil chemotaxis (GO:0048245)4.71237777
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.68759182
17macrophage chemotaxis (GO:0048246)4.65528375
18negative regulation by host of viral transcription (GO:0043922)4.60050223
19positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.49279909
20regulation of lymphocyte chemotaxis (GO:1901623)4.46642867
21neutrophil mediated immunity (GO:0002446)4.45991640
22eosinophil migration (GO:0072677)4.41404488
23regulation of T cell tolerance induction (GO:0002664)4.39498541
24positive T cell selection (GO:0043368)4.38495243
25granulocyte activation (GO:0036230)4.38320295
26antigen processing and presentation of endogenous antigen (GO:0019883)4.24925406
27negative regulation of growth of symbiont in host (GO:0044130)4.24565645
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.24565645
29modulation of growth of symbiont involved in interaction with host (GO:0044144)4.24565645
30regulation of growth of symbiont in host (GO:0044126)4.24565645
31telomere maintenance via semi-conservative replication (GO:0032201)4.22505779
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.21148648
33neutrophil activation (GO:0042119)4.19973646
34DNA strand elongation involved in DNA replication (GO:0006271)4.19829864
35negative regulation of T cell apoptotic process (GO:0070233)4.19699054
36positive regulation of interleukin-8 secretion (GO:2000484)4.18207853
37positive regulation of monocyte chemotaxis (GO:0090026)4.18164608
38disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.16848362
39killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.16848362
40negative regulation of viral genome replication (GO:0045071)4.10826449
41positive regulation of T cell chemotaxis (GO:0010820)4.10103881
42regulation of T cell chemotaxis (GO:0010819)4.10103881
43DNA strand elongation (GO:0022616)4.02066981
44positive regulation of tolerance induction (GO:0002645)4.01227146
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.98127307
46dendritic cell chemotaxis (GO:0002407)3.95553981
47regulation of chronic inflammatory response (GO:0002676)3.95051613
48positive regulation of T cell apoptotic process (GO:0070234)3.89941063
49positive regulation of calcium-mediated signaling (GO:0050850)3.89398480
50regulation of tolerance induction (GO:0002643)3.87717914
51cellular response to zinc ion (GO:0071294)3.84393839
52positive regulation of lymphocyte migration (GO:2000403)3.82904510
53positive regulation of gamma-delta T cell activation (GO:0046645)3.81950462
54positive regulation of cell killing (GO:0031343)3.78313301
55pyrimidine nucleoside catabolic process (GO:0046135)3.78198698
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.78008376
57activated T cell proliferation (GO:0050798)3.77234974
58thymic T cell selection (GO:0045061)3.74999490
59viral transcription (GO:0019083)3.72168598
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71515941
61myeloid leukocyte mediated immunity (GO:0002444)3.70598492
62telomere maintenance via recombination (GO:0000722)3.67578613
63regulation of alpha-beta T cell proliferation (GO:0046640)3.65759212
64cellular defense response (GO:0006968)3.63951595
65lymphocyte chemotaxis (GO:0048247)3.63930792
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62436875
67regulation of cell killing (GO:0031341)3.62006997
68T cell selection (GO:0045058)3.60777925
69translational termination (GO:0006415)3.60525566
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59979459
71mast cell activation (GO:0045576)3.59910813
72monocyte chemotaxis (GO:0002548)3.58999560
73regulation of macrophage chemotaxis (GO:0010758)3.55502278
74regulation of T cell mediated cytotoxicity (GO:0001914)3.54555814
75regulation of mononuclear cell migration (GO:0071675)3.53595230
76cotranslational protein targeting to membrane (GO:0006613)3.51212938
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50117808
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.49656052
79protein targeting to ER (GO:0045047)3.48901988
80cellular extravasation (GO:0045123)3.48770232
81regulation of B cell receptor signaling pathway (GO:0050855)3.48096339
82cytolysis (GO:0019835)3.47821179
83defense response to fungus (GO:0050832)3.45279774
84interferon-gamma production (GO:0032609)3.44687943
85regulation of interleukin-2 biosynthetic process (GO:0045076)3.43018374
86T cell receptor signaling pathway (GO:0050852)3.42281660
87response to fungus (GO:0009620)3.42023655
88respiratory burst (GO:0045730)3.40421470
89DNA replication initiation (GO:0006270)3.36678107
90T cell costimulation (GO:0031295)3.35028441
91protein localization to endoplasmic reticulum (GO:0070972)3.34513765
92leukocyte mediated cytotoxicity (GO:0001909)3.34369890
93regulation of lymphocyte migration (GO:2000401)3.33551506
94dendritic cell migration (GO:0036336)3.33177141
95positive regulation of alpha-beta T cell proliferation (GO:0046641)3.32802485
96positive regulation of defense response to virus by host (GO:0002230)3.31725094
97lymphocyte costimulation (GO:0031294)3.30596389
98establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30559239
99mitotic recombination (GO:0006312)3.29665980
100immunoglobulin mediated immune response (GO:0016064)3.27438417
101translational elongation (GO:0006414)3.25075134
102ribosomal small subunit biogenesis (GO:0042274)3.24912955
103leukocyte aggregation (GO:0070486)3.23699619
104antigen receptor-mediated signaling pathway (GO:0050851)3.23554630
105DNA unwinding involved in DNA replication (GO:0006268)3.18823561
106regulation of T cell apoptotic process (GO:0070232)3.18536570
107regulation of interleukin-8 secretion (GO:2000482)3.13977796
108positive regulation of T cell migration (GO:2000406)3.13892445
109leukocyte degranulation (GO:0043299)3.13514372
110DNA replication checkpoint (GO:0000076)3.12426387
111negative regulation of lymphocyte apoptotic process (GO:0070229)3.11201006
112telomere maintenance via telomere lengthening (GO:0010833)3.10293784
113lymphocyte migration (GO:0072676)3.09723842
114chemokine-mediated signaling pathway (GO:0070098)3.08194797
115killing of cells of other organism (GO:0031640)3.05446185
116disruption of cells of other organism (GO:0044364)3.05446185
117negative regulation of B cell proliferation (GO:0030889)3.05415552
118T cell migration (GO:0072678)3.02440678
119positive regulation of lymphocyte apoptotic process (GO:0070230)3.01525383
120actin nucleation (GO:0045010)2.95308954
121nucleotide-excision repair, DNA gap filling (GO:0006297)2.93898321
122maturation of SSU-rRNA (GO:0030490)2.91794695
123negative T cell selection (GO:0043383)2.89318043
124regulation of T cell receptor signaling pathway (GO:0050856)2.86320194
125negative thymic T cell selection (GO:0045060)2.85943062
126antigen processing and presentation via MHC class Ib (GO:0002475)2.85653214
127translational initiation (GO:0006413)2.82730117
128positive regulation of B cell differentiation (GO:0045579)2.82615280
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81586028
130negative regulation of cell killing (GO:0031342)2.81089718
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81089718
132cellular protein complex disassembly (GO:0043624)2.77447024
133neutrophil activation involved in immune response (GO:0002283)2.76619259
134viral life cycle (GO:0019058)2.75506961
135cellular response to interferon-beta (GO:0035458)2.74298446
136regulation of gamma-delta T cell differentiation (GO:0045586)2.72364418
137regulation of B cell differentiation (GO:0045577)2.71881167
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70964220
139regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69405929
140mast cell degranulation (GO:0043303)2.67934467
141mast cell activation involved in immune response (GO:0002279)2.67934467
142IMP metabolic process (GO:0046040)2.66547042
143nucleobase biosynthetic process (GO:0046112)2.66003076
144positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.64354132
145positive thymic T cell selection (GO:0045059)2.62885764
146pentose-phosphate shunt (GO:0006098)2.62648511
147protein localization to kinetochore (GO:0034501)2.59957601
148reactive oxygen species biosynthetic process (GO:1903409)2.59828605
149formation of translation preinitiation complex (GO:0001731)2.59478930
150positive regulation of isotype switching (GO:0045830)2.59315950
151pseudouridine synthesis (GO:0001522)2.57502688
152cellular response to interleukin-15 (GO:0071350)2.56559034
153regulation of protein heterodimerization activity (GO:0043497)2.55753004
154response to interleukin-15 (GO:0070672)2.54612432
155response to protozoan (GO:0001562)2.54492289
156response to interferon-beta (GO:0035456)2.54305102
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.53383782
158negative regulation of T cell receptor signaling pathway (GO:0050860)2.52579224
159ribonucleoprotein complex biogenesis (GO:0022613)2.52390893
160negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.52111983
161IMP biosynthetic process (GO:0006188)2.51080089
162signal peptide processing (GO:0006465)2.49905904
163defense response to protozoan (GO:0042832)2.49700590
164positive regulation of lamellipodium assembly (GO:0010592)2.48987882
165regulation of gamma-delta T cell activation (GO:0046643)2.48640349
166angiogenesis involved in wound healing (GO:0060055)2.48302223
167regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47984601
168antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.47846836
169CENP-A containing nucleosome assembly (GO:0034080)2.47638623
170positive regulation of B cell mediated immunity (GO:0002714)2.47567818
171positive regulation of immunoglobulin mediated immune response (GO:0002891)2.47567818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27019837
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50891126
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.85396851
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.77707817
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75753298
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75263341
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74063462
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71071200
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62105702
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61118473
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59714178
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43839231
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.43523500
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40763146
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.38666051
16VDR_21846776_ChIP-Seq_THP-1_Human2.37596218
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.33842518
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.31279598
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26732175
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.23860777
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23739700
22MYC_22102868_ChIP-Seq_BL_Human2.22637441
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20160868
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19034887
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18507649
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17895337
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13055997
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12167266
29SPI1_23547873_ChIP-Seq_NB4_Human2.12135695
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06038622
31VDR_23849224_ChIP-Seq_CD4+_Human2.03923274
32SCL_19346495_ChIP-Seq_HPC-7_Human2.01831347
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.01633009
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98140024
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95313794
36MYB_26560356_Chip-Seq_TH2_Human1.94155407
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.92703320
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86869637
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85727778
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84400282
41FOXP3_21729870_ChIP-Seq_TREG_Human1.83433414
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83202789
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82373489
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81220303
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81187708
46GATA3_26560356_Chip-Seq_TH2_Human1.79729307
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77254461
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71857250
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71640967
50* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68466011
51MYB_26560356_Chip-Seq_TH1_Human1.67776622
52XRN2_22483619_ChIP-Seq_HELA_Human1.67281443
53VDR_24763502_ChIP-Seq_THP-1_Human1.66281825
54MAF_26560356_Chip-Seq_TH1_Human1.64126944
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62498277
56* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61455379
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.59145328
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58236985
59CIITA_25753668_ChIP-Seq_RAJI_Human1.57696612
60SPI1_23127762_ChIP-Seq_K562_Human1.56129186
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55471147
62UTX_26944678_Chip-Seq_JUKART_Human1.55131382
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53550089
64* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49211601
65DCP1A_22483619_ChIP-Seq_HELA_Human1.47946911
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.47456041
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45161011
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.44945536
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42693673
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.41771353
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39115020
72BCL6_27268052_Chip-Seq_Bcells_Human1.38704011
73GABP_19822575_ChIP-Seq_HepG2_Human1.37311712
74* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36675640
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30772801
76GATA1_22025678_ChIP-Seq_K562_Human1.29833312
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.28076393
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.27957991
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26672902
80ELK1_19687146_ChIP-ChIP_HELA_Human1.26002309
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25122182
82* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23391934
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23296973
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21824783
85MAF_26560356_Chip-Seq_TH2_Human1.21320249
86TTF2_22483619_ChIP-Seq_HELA_Human1.21117864
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18415445
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18210932
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17920369
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17440943
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17206827
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16721273
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13507138
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12266370
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10415573
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.08972470
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08824995
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07270418
99BCOR_27268052_Chip-Seq_Bcells_Human1.06560882
100RUNX_20019798_ChIP-Seq_JUKART_Human1.05053405
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04883230
102GATA3_27048872_Chip-Seq_THYMUS_Human1.03116841
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01703178
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01015128
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00791987
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99822265
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99248987
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99003950
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98809713
110VDR_24787735_ChIP-Seq_THP-1_Human0.98531948
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97225716
112KDM5A_27292631_Chip-Seq_BREAST_Human0.97040725
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96980746
114AR_21909140_ChIP-Seq_LNCAP_Human0.96768406
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96090868
116* P300_27268052_Chip-Seq_Bcells_Human0.95737115
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95699604
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95636038
119TCF7_22412390_ChIP-Seq_EML_Mouse0.95396650
120PU_27001747_Chip-Seq_BMDM_Mouse0.95270234
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94074722
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.93038037
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92113659
124NANOG_20526341_ChIP-Seq_ESCs_Human0.91296304
125* ELF1_20517297_ChIP-Seq_JURKAT_Human0.91031113
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.89747091
127TAF2_19829295_ChIP-Seq_ESCs_Human0.89593377
128RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87833750
129SA1_27219007_Chip-Seq_Bcells_Human0.87688594
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86929783
131* GATA3_26560356_Chip-Seq_TH1_Human0.83635985
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82482213
133KDM2B_26808549_Chip-Seq_DND41_Human0.78642938
134SPI1_20517297_ChIP-Seq_HL60_Human0.78037946
135E2F1_20622854_ChIP-Seq_HELA_Human0.77183696
136CTCF_20526341_ChIP-Seq_ESCs_Human0.76091947
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74986293
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74874707
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72326977
140KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71795168
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70690746
142STAT1_20625510_ChIP-Seq_HELA_Human0.69266434
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69047069
144GATA1_19941826_ChIP-Seq_K562_Human0.68757234
145HTT_18923047_ChIP-ChIP_STHdh_Human0.67273290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.77235225
2MP0005671_abnormal_response_to3.55256863
3MP0001835_abnormal_antigen_presentation3.34341689
4MP0003763_abnormal_thymus_physiology3.31474762
5MP0003693_abnormal_embryo_hatching3.11446022
6MP0009785_altered_susceptibility_to3.07623914
7MP0002166_altered_tumor_susceptibility2.72315075
8MP0005025_abnormal_response_to2.72015054
9MP0003436_decreased_susceptibility_to2.66234989
10MP0003724_increased_susceptibility_to2.61861366
11MP0005000_abnormal_immune_tolerance2.60977442
12MP0009333_abnormal_splenocyte_physiolog2.57297916
13MP0002420_abnormal_adaptive_immunity2.53417585
14MP0001819_abnormal_immune_cell2.50582274
15MP0002398_abnormal_bone_marrow2.48044923
16MP0002419_abnormal_innate_immunity2.47034199
17MP0001800_abnormal_humoral_immune2.44549549
18MP0008057_abnormal_DNA_replication2.42510836
19MP0010094_abnormal_chromosome_stability2.38366291
20MP0002006_tumorigenesis2.36628439
21MP0002148_abnormal_hypersensitivity_rea2.35306824
22MP0002723_abnormal_immune_serum2.34974045
23MP0005464_abnormal_platelet_physiology2.28194087
24MP0002452_abnormal_antigen_presenting2.23543001
25MP0000685_abnormal_immune_system2.22320758
26MP0000716_abnormal_immune_system2.19333330
27MP0000490_abnormal_crypts_of2.14998159
28MP0003111_abnormal_nucleus_morphology2.10519726
29MP0002722_abnormal_immune_system2.08131649
30MP0003303_peritoneal_inflammation2.07214825
31MP0000689_abnormal_spleen_morphology2.00473165
32MP0000858_altered_metastatic_potential1.97904572
33MP0002405_respiratory_system_inflammati1.97438817
34MP0005387_immune_system_phenotype1.96347800
35MP0001790_abnormal_immune_system1.96347800
36MP0003077_abnormal_cell_cycle1.96036519
37MP0004957_abnormal_blastocyst_morpholog1.96001284
38MP0000465_gastrointestinal_hemorrhage1.95112101
39MP0002429_abnormal_blood_cell1.94265647
40MP0001853_heart_inflammation1.90996347
41MP0005075_abnormal_melanosome_morpholog1.89779663
42MP0001545_abnormal_hematopoietic_system1.85040989
43MP0005397_hematopoietic_system_phenotyp1.85040989
44MP0000703_abnormal_thymus_morphology1.83990979
45MP0010155_abnormal_intestine_physiology1.83551980
46MP0005174_abnormal_tail_pigmentation1.82433988
47MP0004808_abnormal_hematopoietic_stem1.81108186
48MP0008058_abnormal_DNA_repair1.69310291
49MP0003172_abnormal_lysosome_physiology1.68855469
50MP0001845_abnormal_inflammatory_respons1.67012877
51MP0001873_stomach_inflammation1.63880973
52MP0003866_abnormal_defecation1.62428883
53MP0006082_CNS_inflammation1.61038609
54MP0008007_abnormal_cellular_replicative1.56945478
55MP0002277_abnormal_respiratory_mucosa1.53853691
56MP0002019_abnormal_tumor_incidence1.48506518
57MP0003045_fibrosis1.38114385
58MP0010307_abnormal_tumor_latency1.35869121
59MP0001533_abnormal_skeleton_physiology1.35754437
60MP0005083_abnormal_biliary_tract1.28853535
61MP0008469_abnormal_protein_level1.25973522
62MP0003448_altered_tumor_morphology1.21521903
63MP0000015_abnormal_ear_pigmentation1.21004039
64MP0002095_abnormal_skin_pigmentation1.18904379
65MP0004947_skin_inflammation1.08035242
66MP0003300_gastrointestinal_ulcer1.03363823
67MP0002933_joint_inflammation0.97917106
68MP0000343_altered_response_to0.94987451
69MP0005166_decreased_susceptibility_to0.94097817
70MP0005058_abnormal_lysosome_morphology0.93687489
71MP0003806_abnormal_nucleotide_metabolis0.91091120
72MP0000313_abnormal_cell_death0.90648662
73MP0001851_eye_inflammation0.89489687
74MP0003878_abnormal_ear_physiology0.89199227
75MP0005377_hearing/vestibular/ear_phenot0.89199227
76MP0002132_abnormal_respiratory_system0.88302708
77MP0003183_abnormal_peptide_metabolism0.86950457
78MP0009763_increased_sensitivity_to0.86829397
79MP0010352_gastrointestinal_tract_polyps0.84788749
80MP0005451_abnormal_body_composition0.82558619
81MP0003786_premature_aging0.80720109
82MP0001663_abnormal_digestive_system0.80702943
83MP0006054_spinal_hemorrhage0.80033743
84MP0003186_abnormal_redox_activity0.79366745
85MP0002009_preneoplasia0.78958785
86MP0000350_abnormal_cell_proliferation0.78320938
87MP0003656_abnormal_erythrocyte_physiolo0.77712448
88MP0008873_increased_physiological_sensi0.77438977
89MP0002693_abnormal_pancreas_physiology0.76493398
90MP0002163_abnormal_gland_morphology0.76239621
91MP0002877_abnormal_melanocyte_morpholog0.76214664
92MP0009379_abnormal_foot_pigmentation0.75622808
93MP0005310_abnormal_salivary_gland0.74551791
94MP0001919_abnormal_reproductive_system0.73670034
95MP0008932_abnormal_embryonic_tissue0.73227476
96MP0000920_abnormal_myelination0.70755425
97MP0004381_abnormal_hair_follicle0.69135559
98MP0009764_decreased_sensitivity_to0.66312933
99MP0002138_abnormal_hepatobiliary_system0.66037180
100MP0001764_abnormal_homeostasis0.65978085
101MP0005390_skeleton_phenotype0.62529105
102MP0000371_diluted_coat_color0.62216299
103MP0006036_abnormal_mitochondrial_physio0.61333274
104MP0000249_abnormal_blood_vessel0.61004513
105MP0002876_abnormal_thyroid_physiology0.59769950
106MP0000477_abnormal_intestine_morphology0.59498882
107MP0009278_abnormal_bone_marrow0.59153361
108MP0001730_embryonic_growth_arrest0.58512185
109MP0000358_abnormal_cell_content/0.57975894
110MP0001986_abnormal_taste_sensitivity0.55544888
111MP0003075_altered_response_to0.54655373
112MP0003221_abnormal_cardiomyocyte_apopto0.54245674
113MP0005164_abnormal_response_to0.53764615
114MP0004147_increased_porphyrin_level0.53244700
115MP0005319_abnormal_enzyme/_coenzyme0.53150618
116MP0009643_abnormal_urine_homeostasis0.52946484
117MP0003690_abnormal_glial_cell0.52549920
118MP0004883_abnormal_blood_vessel0.51291332
119MP0001542_abnormal_bone_strength0.50613772
120MP0003795_abnormal_bone_structure0.49835270
121MP0001765_abnormal_ion_homeostasis0.49316630
122MP0001905_abnormal_dopamine_level0.49249358
123MP0002998_abnormal_bone_remodeling0.49183320
124MP0004130_abnormal_muscle_cell0.47633242
125MP0004782_abnormal_surfactant_physiolog0.47554440
126MP0009765_abnormal_xenobiotic_induced0.47360651
127MP0002136_abnormal_kidney_physiology0.46614934
128MP0005584_abnormal_enzyme/coenzyme_acti0.44142697
129MP0000569_abnormal_digit_pigmentation0.43720920
130MP0004145_abnormal_muscle_electrophysio0.43626613
131MP0008874_decreased_physiological_sensi0.43002872

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.60774830
2Elevated erythrocyte sedimentation rate (HP:0003565)5.43285320
3Increased IgM level (HP:0003496)4.53769702
4Chronic otitis media (HP:0000389)4.27115589
5Myositis (HP:0100614)4.21519640
6IgM deficiency (HP:0002850)4.20759665
7Recurrent abscess formation (HP:0002722)4.15481748
8Abnormal number of erythroid precursors (HP:0012131)3.99407557
9Hypoproteinemia (HP:0003075)3.95979226
10Obstructive lung disease (HP:0006536)3.85838139
11Chronic obstructive pulmonary disease (HP:0006510)3.85838139
12Abnormality of cells of the erythroid lineage (HP:0012130)3.85552066
13Abnormality of the prostate (HP:0008775)3.85249180
14Petechiae (HP:0000967)3.74512308
15Eczematoid dermatitis (HP:0000976)3.70825365
16Aplastic anemia (HP:0001915)3.64332472
17Recurrent bacterial skin infections (HP:0005406)3.61638128
18Chronic diarrhea (HP:0002028)3.54126072
19Reduced antithrombin III activity (HP:0001976)3.42750917
20Abnormality of T cells (HP:0002843)3.34603479
21Recurrent bronchitis (HP:0002837)3.33221144
22Reticulocytopenia (HP:0001896)3.32280036
23T lymphocytopenia (HP:0005403)3.30755268
24Abnormality of T cell physiology (HP:0011840)3.25342071
25Type I transferrin isoform profile (HP:0003642)3.17648283
26Meningitis (HP:0001287)3.17356656
27Abnormality of T cell number (HP:0011839)3.09975058
28Recurrent viral infections (HP:0004429)3.06297145
29Mediastinal lymphadenopathy (HP:0100721)3.02789503
30Autoimmune thrombocytopenia (HP:0001973)3.02297898
31Agammaglobulinemia (HP:0004432)2.99997395
32Nasal polyposis (HP:0100582)2.98474477
33Recurrent fungal infections (HP:0002841)2.97756379
34B lymphocytopenia (HP:0010976)2.96535134
35Abnormality of B cell number (HP:0010975)2.96535134
36Eosinophilia (HP:0001880)2.96053132
37Severe combined immunodeficiency (HP:0004430)2.92400526
38Abnormality of eosinophils (HP:0001879)2.89957869
39Chest pain (HP:0100749)2.88487891
40Granulocytopenia (HP:0001913)2.88198100
41Joint swelling (HP:0001386)2.84351747
42IgG deficiency (HP:0004315)2.84096932
43Pulmonary embolism (HP:0002204)2.79239765
44Pulmonary fibrosis (HP:0002206)2.78990844
45Combined immunodeficiency (HP:0005387)2.77229807
46Leukocytosis (HP:0001974)2.75728079
47Hemiplegia (HP:0002301)2.69222174
48Hypochromic anemia (HP:0001931)2.67248030
49Lymphopenia (HP:0001888)2.66865108
50Hypergammaglobulinemia (HP:0010702)2.66346032
51Stomatitis (HP:0010280)2.63972781
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.63451755
53Abnormal protein glycosylation (HP:0012346)2.62969578
54Abnormal glycosylation (HP:0012345)2.62969578
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62969578
56Abnormal protein N-linked glycosylation (HP:0012347)2.62969578
57Periodontitis (HP:0000704)2.61019598
58Pulmonary infiltrates (HP:0002113)2.60309702
59Vasculitis (HP:0002633)2.59570714
60Hemoptysis (HP:0002105)2.58808937
61Lymphoma (HP:0002665)2.58677828
62Papilledema (HP:0001085)2.58303610
63Recurrent skin infections (HP:0001581)2.58102741
64Epistaxis (HP:0000421)2.57871249
65Orchitis (HP:0100796)2.51380521
66Keratoconjunctivitis (HP:0001096)2.49359481
67Gastrointestinal infarctions (HP:0005244)2.45353149
68Ureteral obstruction (HP:0006000)2.43952493
69Hypoplasia of the thymus (HP:0000778)2.43943846
70Abnormality of the nasal mucosa (HP:0000433)2.42487340
71Urticaria (HP:0001025)2.41692705
72Poikiloderma (HP:0001029)2.41424233
73Increased serum ferritin (HP:0003281)2.39218702
74Acute hepatic failure (HP:0006554)2.39143124
75Prolonged bleeding time (HP:0003010)2.39113738
76Abnormality of macrophages (HP:0004311)2.36573539
77Panhypogammaglobulinemia (HP:0003139)2.34056343
78Chronic mucocutaneous candidiasis (HP:0002728)2.33831260
79Recurrent cutaneous fungal infections (HP:0011370)2.33831260
80Oral leukoplakia (HP:0002745)2.33075369
81Hypochromic microcytic anemia (HP:0004840)2.32859687
82Anorexia (HP:0002039)2.32435829
83Retrobulbar optic neuritis (HP:0100654)2.32302812
84Optic neuritis (HP:0100653)2.32302812
85Gangrene (HP:0100758)2.29273413
86Abnormal platelet function (HP:0011869)2.28479340
87Impaired platelet aggregation (HP:0003540)2.28479340
88Abnormality of the pleura (HP:0002103)2.26209594
89Abnormality of the pericardium (HP:0001697)2.26106252
90Episodic fever (HP:0001954)2.25170674
91Pustule (HP:0200039)2.24052500
92Premature graying of hair (HP:0002216)2.20968148
93Autoimmune hemolytic anemia (HP:0001890)2.20908324
94Encephalitis (HP:0002383)2.19752577
95Amaurosis fugax (HP:0100576)2.19674795
96Gingivitis (HP:0000230)2.19025899
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.18998158
98Pancytopenia (HP:0001876)2.18580656
99Neutropenia (HP:0001875)2.18502302
100Recurrent gram-negative bacterial infections (HP:0005420)2.18303507
101Thyroiditis (HP:0100646)2.16781252
102Glomerulopathy (HP:0100820)2.13925992
103Polyneuropathy (HP:0001271)2.11885905
104Ureteral stenosis (HP:0000071)2.11823074
105Agnosia (HP:0010524)2.11801175
106Hepatosplenomegaly (HP:0001433)2.11521268
107Macrocytic anemia (HP:0001972)2.11493585
108Arterial thrombosis (HP:0004420)2.10606894
109Abnormality of iron homeostasis (HP:0011031)2.10122095
110Inflammation of the large intestine (HP:0002037)2.09183824
111Pallor (HP:0000980)2.07720633
112Spontaneous hematomas (HP:0007420)2.06006513
113Keratitis (HP:0000491)2.04871574
114Abnormal albumin level (HP:0012116)2.04173149
115Hypoalbuminemia (HP:0003073)2.04173149
116Birth length less than 3rd percentile (HP:0003561)2.03359102
117Bone marrow hypocellularity (HP:0005528)2.03337466
118Thrombophlebitis (HP:0004418)2.00036283
119Skin ulcer (HP:0200042)1.98845021
120Albinism (HP:0001022)1.97800046
121Myelodysplasia (HP:0002863)1.96655313
122Basal ganglia calcification (HP:0002135)1.94171378
123Bronchitis (HP:0012387)1.93476207
124Vacuolated lymphocytes (HP:0001922)1.92876174
125Keratoconjunctivitis sicca (HP:0001097)1.92647200
126Increased IgE level (HP:0003212)1.92495786
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.91664129
128Abnormality of male internal genitalia (HP:0000022)1.91516031
129Gastrointestinal inflammation (HP:0004386)1.90744166
130Skin rash (HP:0000988)1.89834438
131Entropion (HP:0000621)1.89347016
132Abnormality of transition element cation homeostasis (HP:0011030)1.89337667
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88716848
134Cellulitis (HP:0100658)1.88380879
135IgA deficiency (HP:0002720)1.84732881
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83747596
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83747596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.60166458
2TXK3.33490821
3STK162.96962179
4EIF2AK32.82892344
5IRAK42.74397620
6TEC2.57812293
7BLK2.49048024
8EIF2AK12.35869073
9CDC72.29801753
10KIT2.20914949
11GRK72.15299843
12ZAP702.13838243
13PIM22.11221913
14BTK2.07993598
15NME22.06701261
16ITK2.05879087
17TESK22.02454086
18WEE11.91997784
19BUB11.87249918
20MAP3K121.84426770
21EEF2K1.75215707
22KDR1.69751012
23VRK11.66516794
24FES1.64298638
25JAK31.64110759
26SCYL21.57665123
27PRKCQ1.57390259
28TYK21.57232697
29SYK1.56901310
30TBK11.44021602
31TAOK31.42762356
32ADRBK21.37268417
33IKBKE1.35539548
34GRK61.27239025
35RPS6KA41.26328959
36LCK1.24576317
37TSSK61.24026636
38NEK21.20718779
39BCKDK1.18934831
40STK101.18749524
41ACVR1B1.17937910
42CLK11.15985796
43PIM11.09147874
44ATR1.06546138
45FLT31.04327914
46LYN1.04216912
47BMPR21.02751941
48IRAK31.01597907
49MAP3K141.01380625
50JAK11.00569604
51LRRK21.00143041
52DAPK20.98716491
53BRSK20.96704533
54MARK30.96682155
55CDK40.96257830
56SRPK10.96131221
57CDK70.95495818
58MAP2K30.93314631
59MAP3K60.93267058
60ERN10.91857507
61RPS6KB20.89403517
62TYRO30.87111790
63FYN0.87068737
64HCK0.84475625
65PIK3CA0.82392858
66EIF2AK20.82032144
67CSK0.80168364
68CSF1R0.79714346
69PIK3CG0.78285238
70STK40.77349157
71TLK10.77236445
72DAPK10.74114820
73NUAK10.73547133
74VRK20.73288413
75AURKB0.72224044
76IKBKB0.71676322
77CAMKK20.71445410
78PASK0.71354350
79TESK10.71244179
80CDK80.69918185
81DYRK30.69887295
82CCNB10.69852358
83PDK10.68549192
84PAK40.68352433
85TNIK0.67922127
86CDK190.67156020
87MKNK10.65335960
88MAPK40.64526488
89TGFBR20.63815874
90MAP3K80.62618310
91MAP3K30.62580382
92TAOK10.62414945
93MKNK20.62018009
94NLK0.61347627
95RIPK40.61271538
96ILK0.60725910
97RPS6KA60.60591593
98LIMK10.60534881
99PKN20.59181139
100PLK10.58095497
101RAF10.57666523
102BRSK10.56755956
103PLK40.56007576
104MST40.54445388
105RPS6KC10.54023608
106RPS6KL10.54023608
107ZAK0.51584691
108FGR0.51481445
109WNK40.50388456
110TAOK20.50085995
111PRKCH0.49235729
112MAPKAPK30.48950782
113TNK20.48544138
114MAPKAPK20.47532900
115MAP3K50.45111834
116GRK50.44431432
117MYLK0.44025532
118ABL20.43932563
119TGFBR10.42119099
120JAK20.42090257
121CAMKK10.41195854
122INSR0.40582481
123MAP3K70.38438208
124ADRBK10.38034242
125MAP3K110.37843236
126MAPK110.36320357
127MATK0.36058765
128TRPM70.36034069
129PDGFRB0.35376186
130PRKCD0.34298083
131CSNK2A20.34183557
132CSNK2A10.34005029
133MAP2K60.33928698
134PDPK10.33711571
135HIPK20.29206435
136PRPF4B0.27739903
137GRK10.26603984
138MAP4K20.26106645
139IGF1R0.25055352
140PRKCA0.22122138
141EPHB10.20823849
142ABL10.20431143
143MAP3K10.18758166
144STK110.18059781
145PTK2B0.17567732
146NME10.15890064
147MAPK120.15608023
148FGFR10.15557224
149PRKD10.15112719
150MAPK30.11516741
151SRC0.11446289

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60603462
2Ribosome_Homo sapiens_hsa030103.33810914
3Mismatch repair_Homo sapiens_hsa034303.24547329
4Primary immunodeficiency_Homo sapiens_hsa053402.96137164
5Base excision repair_Homo sapiens_hsa034102.61154980
6Homologous recombination_Homo sapiens_hsa034402.46924977
7Antigen processing and presentation_Homo sapiens_hsa046122.41057521
8Proteasome_Homo sapiens_hsa030502.29625659
9Graft-versus-host disease_Homo sapiens_hsa053322.24282118
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20038179
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15504020
12Rheumatoid arthritis_Homo sapiens_hsa053232.11242326
13Spliceosome_Homo sapiens_hsa030402.02741537
14Nucleotide excision repair_Homo sapiens_hsa034201.98602585
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95478008
16RNA polymerase_Homo sapiens_hsa030201.91375498
17Protein export_Homo sapiens_hsa030601.87232628
18Leishmaniasis_Homo sapiens_hsa051401.81186909
19Pyrimidine metabolism_Homo sapiens_hsa002401.80393152
20Allograft rejection_Homo sapiens_hsa053301.77412848
21Asthma_Homo sapiens_hsa053101.75476930
22Measles_Homo sapiens_hsa051621.73671854
23Non-homologous end-joining_Homo sapiens_hsa034501.62489244
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.61057079
25Pentose phosphate pathway_Homo sapiens_hsa000301.55582378
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53971477
27Hematopoietic cell lineage_Homo sapiens_hsa046401.42599477
28N-Glycan biosynthesis_Homo sapiens_hsa005101.41341829
29Cell cycle_Homo sapiens_hsa041101.39965073
30Fanconi anemia pathway_Homo sapiens_hsa034601.37735282
31Herpes simplex infection_Homo sapiens_hsa051681.36743097
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.35471810
33RNA transport_Homo sapiens_hsa030131.35382074
34One carbon pool by folate_Homo sapiens_hsa006701.34592061
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33855838
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30651038
37Other glycan degradation_Homo sapiens_hsa005111.29572933
38T cell receptor signaling pathway_Homo sapiens_hsa046601.27540489
39Renin-angiotensin system_Homo sapiens_hsa046141.25153096
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16634963
41RNA degradation_Homo sapiens_hsa030181.15840879
42Legionellosis_Homo sapiens_hsa051341.05124325
43Osteoclast differentiation_Homo sapiens_hsa043801.02776250
44African trypanosomiasis_Homo sapiens_hsa051430.99774468
45p53 signaling pathway_Homo sapiens_hsa041150.99726065
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96698468
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96564452
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96253266
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95546609
50B cell receptor signaling pathway_Homo sapiens_hsa046620.95066757
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.94056132
52Apoptosis_Homo sapiens_hsa042100.90391094
53Purine metabolism_Homo sapiens_hsa002300.90223390
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89415050
55Epstein-Barr virus infection_Homo sapiens_hsa051690.86926193
56Autoimmune thyroid disease_Homo sapiens_hsa053200.85863827
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83040236
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.82684584
59Viral myocarditis_Homo sapiens_hsa054160.82203404
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79677704
61Shigellosis_Homo sapiens_hsa051310.79631283
62Influenza A_Homo sapiens_hsa051640.78105674
63Pertussis_Homo sapiens_hsa051330.78044486
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77920640
65Systemic lupus erythematosus_Homo sapiens_hsa053220.77174249
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75912706
67Oxidative phosphorylation_Homo sapiens_hsa001900.74245638
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73988184
69Hepatitis B_Homo sapiens_hsa051610.72415795
70Basal transcription factors_Homo sapiens_hsa030220.71985645
71Toxoplasmosis_Homo sapiens_hsa051450.68865159
72Prion diseases_Homo sapiens_hsa050200.68128422
73Tuberculosis_Homo sapiens_hsa051520.67892019
74Type I diabetes mellitus_Homo sapiens_hsa049400.65783893
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65381797
76Galactose metabolism_Homo sapiens_hsa000520.65327934
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65061862
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63569106
79Parkinsons disease_Homo sapiens_hsa050120.62100851
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61650525
81HTLV-I infection_Homo sapiens_hsa051660.60107112
82Acute myeloid leukemia_Homo sapiens_hsa052210.59684508
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59340921
84Viral carcinogenesis_Homo sapiens_hsa052030.59013332
85Sulfur relay system_Homo sapiens_hsa041220.56650893
86Lysosome_Homo sapiens_hsa041420.56379551
87Malaria_Homo sapiens_hsa051440.56135961
88Linoleic acid metabolism_Homo sapiens_hsa005910.55402361
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.54372735
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52761297
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52088565
92Regulation of autophagy_Homo sapiens_hsa041400.51208167
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50945473
94Salmonella infection_Homo sapiens_hsa051320.49378400
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.49080371
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48501495
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48322742
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46650796
99Endocytosis_Homo sapiens_hsa041440.46408640
100Chemokine signaling pathway_Homo sapiens_hsa040620.45720733
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44357638
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43246537
103Staphylococcus aureus infection_Homo sapiens_hsa051500.42628188
104VEGF signaling pathway_Homo sapiens_hsa043700.42139886
105Platelet activation_Homo sapiens_hsa046110.41068395
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41010542
107Thyroid cancer_Homo sapiens_hsa052160.39849916
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37777756
109Folate biosynthesis_Homo sapiens_hsa007900.37371895
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35920472
111mRNA surveillance pathway_Homo sapiens_hsa030150.34209003
112Phagosome_Homo sapiens_hsa041450.33949680
113Biosynthesis of amino acids_Homo sapiens_hsa012300.33575659
114Alzheimers disease_Homo sapiens_hsa050100.33096207
115TNF signaling pathway_Homo sapiens_hsa046680.33092261
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.31805116
117Small cell lung cancer_Homo sapiens_hsa052220.30468307
118Chronic myeloid leukemia_Homo sapiens_hsa052200.28732441
119Pancreatic cancer_Homo sapiens_hsa052120.27816180
120Non-small cell lung cancer_Homo sapiens_hsa052230.25887289
121Phototransduction_Homo sapiens_hsa047440.25034861
122Arachidonic acid metabolism_Homo sapiens_hsa005900.23541287
123Collecting duct acid secretion_Homo sapiens_hsa049660.22725627
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.22536002
125Caffeine metabolism_Homo sapiens_hsa002320.21574698
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.20676821
127Hepatitis C_Homo sapiens_hsa051600.19780512
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17750593
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.14472891
130Nitrogen metabolism_Homo sapiens_hsa009100.13810370
131Ether lipid metabolism_Homo sapiens_hsa005650.13245877
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.12422447
133MAPK signaling pathway_Homo sapiens_hsa040100.11451605
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08760801
135Olfactory transduction_Homo sapiens_hsa047400.08216420
136Ras signaling pathway_Homo sapiens_hsa040140.07774634
137Peroxisome_Homo sapiens_hsa041460.04787140
138Huntingtons disease_Homo sapiens_hsa050160.00371311

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