CST8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.97888633
2single fertilization (GO:0007338)9.83117542
3cell-cell recognition (GO:0009988)9.76660183
4binding of sperm to zona pellucida (GO:0007339)9.75917874
5epithelial cilium movement (GO:0003351)9.69057777
6spermatid development (GO:0007286)9.08295163
7axonemal dynein complex assembly (GO:0070286)8.75620868
8cilium or flagellum-dependent cell motility (GO:0001539)8.58975083
9motile cilium assembly (GO:0044458)8.55113472
10cilium movement (GO:0003341)7.67665587
11fertilization (GO:0009566)7.55703444
12spermatid nucleus differentiation (GO:0007289)7.28902639
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.10014844
14regulation of cilium movement (GO:0003352)6.42826427
15synaptonemal complex assembly (GO:0007130)6.35908845
16synaptonemal complex organization (GO:0070193)6.34619946
17male meiosis (GO:0007140)6.27586026
18sexual reproduction (GO:0019953)6.17721090
19negative regulation of inclusion body assembly (GO:0090084)5.97652355
20spermatogenesis (GO:0007283)5.93720823
21male gamete generation (GO:0048232)5.91347654
22gamete generation (GO:0007276)5.42706100
23regulation of inclusion body assembly (GO:0090083)5.41635759
24piRNA metabolic process (GO:0034587)5.40732068
25organic cation transport (GO:0015695)5.31103612
26microtubule depolymerization (GO:0007019)5.19110257
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.11597102
28calcium ion-dependent exocytosis (GO:0017156)5.07971031
29germ cell development (GO:0007281)4.94655907
30single strand break repair (GO:0000012)4.86505042
31glycerol ether metabolic process (GO:0006662)4.85814077
32cell recognition (GO:0008037)4.79505312
33ether metabolic process (GO:0018904)4.47748059
34ventricular system development (GO:0021591)4.42621782
35multicellular organismal reproductive process (GO:0048609)4.30715381
36chromosome organization involved in meiosis (GO:0070192)4.14328246
37regulation of T cell tolerance induction (GO:0002664)4.06756833
38positive regulation of tolerance induction (GO:0002645)4.05435344
39protein K11-linked deubiquitination (GO:0035871)3.98550285
40chaperone-mediated protein complex assembly (GO:0051131)3.93659006
41microtubule severing (GO:0051013)3.92528119
42chromosome condensation (GO:0030261)3.92151971
43regulation of microtubule-based movement (GO:0060632)3.89447205
44production of molecular mediator involved in inflammatory response (GO:0002532)3.80039181
45monoubiquitinated protein deubiquitination (GO:0035520)3.63566236
46DNA packaging (GO:0006323)3.53642830
47meiotic nuclear division (GO:0007126)3.51024506
48regulation of tolerance induction (GO:0002643)3.46543741
49DNA methylation involved in gamete generation (GO:0043046)3.45563750
50estrogen biosynthetic process (GO:0006703)3.39866937
51genitalia morphogenesis (GO:0035112)3.32898703
52multicellular organismal development (GO:0007275)3.30744249
53male meiosis I (GO:0007141)3.29760773
54left/right pattern formation (GO:0060972)3.21633471
55amino-acid betaine transport (GO:0015838)2.97776217
56carnitine transport (GO:0015879)2.97776217
57protein refolding (GO:0042026)2.93150423
58androgen biosynthetic process (GO:0006702)2.90657288
59glycolytic process (GO:0006096)2.90641978
60sequestering of actin monomers (GO:0042989)2.88081829
61positive regulation of macrophage activation (GO:0043032)2.82008983
62alditol metabolic process (GO:0019400)2.81248914
63macroautophagy (GO:0016236)2.80946668
64nucleus organization (GO:0006997)2.76736674
65chromatin silencing (GO:0006342)2.68984737
66kynurenine metabolic process (GO:0070189)2.64477025
67microtubule polymerization or depolymerization (GO:0031109)2.64279905
68polyol catabolic process (GO:0046174)2.63117220
69centriole assembly (GO:0098534)2.63113857
70carnitine transmembrane transport (GO:1902603)2.63043150
71meiosis I (GO:0007127)2.55059956
72glycerol metabolic process (GO:0006071)2.51026824
73regulation of chronic inflammatory response (GO:0002676)2.47622266
74lactate metabolic process (GO:0006089)2.46105108
75cell redox homeostasis (GO:0045454)2.45529800
76glucocorticoid biosynthetic process (GO:0006704)2.42969580
77regulation of macrophage activation (GO:0043030)2.40709910
78cilium organization (GO:0044782)2.37520493
79meiotic cell cycle (GO:0051321)2.37268342
80microtubule-based movement (GO:0007018)2.36003901
81cellular component assembly involved in morphogenesis (GO:0010927)2.35734526
82centriole replication (GO:0007099)2.35612847
83nucleoside diphosphate phosphorylation (GO:0006165)2.34561642
84transepithelial transport (GO:0070633)2.32937610
85UTP biosynthetic process (GO:0006228)2.32294754
86protein polyglutamylation (GO:0018095)2.31453914
87mitotic sister chromatid cohesion (GO:0007064)2.30131097
88heterotypic cell-cell adhesion (GO:0034113)2.29956460
89cilium assembly (GO:0042384)2.28617030
90cell wall macromolecule metabolic process (GO:0044036)15.6469165
91cell wall macromolecule catabolic process (GO:0016998)15.6469165
92fusion of sperm to egg plasma membrane (GO:0007342)14.1349847
93sperm motility (GO:0030317)12.5559236
94seminiferous tubule development (GO:0072520)12.0398399
95acrosome assembly (GO:0001675)11.3421681
96multicellular organism reproduction (GO:0032504)11.0650793
97sperm-egg recognition (GO:0035036)10.8939537
98plasma membrane fusion (GO:0045026)10.7856501
99acrosome reaction (GO:0007340)10.2214533
100sperm capacitation (GO:0048240)10.2156347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.23012911
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.47719228
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42067445
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37319333
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.22641120
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65667785
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61556417
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58383176
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53430157
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.47447648
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40546881
12EZH2_22144423_ChIP-Seq_EOC_Human2.17615669
13STAT1_17558387_ChIP-Seq_HELA_Human2.02214509
14KDM2B_26808549_Chip-Seq_REH_Human1.97994463
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92378880
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91610349
17TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.87345094
18SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86963005
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.83924974
20SOX2_22085726_ChIP-Seq_NPCs_Mouse1.82557483
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.78843727
22GATA3_21867929_ChIP-Seq_TH1_Mouse1.76992217
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75850076
24* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75447308
25ZNF274_21170338_ChIP-Seq_K562_Hela1.75278770
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74266691
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69001811
28VDR_22108803_ChIP-Seq_LS180_Human1.62917229
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.58021401
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57593624
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56814781
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56714850
33GATA3_21867929_ChIP-Seq_CD8_Mouse1.54699852
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52490589
35GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47283848
36ESRRB_18555785_Chip-Seq_ESCs_Mouse1.46084163
37CRX_20693478_ChIP-Seq_RETINA_Mouse1.43219697
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42865071
39FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42676044
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.40963691
41SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38346908
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37198520
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.36326787
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.33972100
45OCT4_18555785_Chip-Seq_ESCs_Mouse1.33733815
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32278551
47RAD21_21589869_ChIP-Seq_MESCs_Mouse1.32041232
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31993106
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31819087
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.30799693
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.30688337
52P53_22387025_ChIP-Seq_ESCs_Mouse1.30282630
53P300_18555785_Chip-Seq_ESCs_Mouse1.29014693
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.27886002
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27313032
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.26473824
57CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26379942
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24811718
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24811718
60KLF4_18555785_Chip-Seq_ESCs_Mouse1.24344192
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24120342
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23343540
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23313607
64P53_21459846_ChIP-Seq_SAOS-2_Human1.23239725
65FLI1_21867929_ChIP-Seq_CD8_Mouse1.23173101
66LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22219459
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22142807
68CBP_20019798_ChIP-Seq_JUKART_Human1.20869171
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20869171
70* CTCF_18555785_Chip-Seq_ESCs_Mouse1.19617443
71SPI1_26923725_Chip-Seq_HPCs_Mouse1.19271853
72ESET_19884257_ChIP-Seq_ESCs_Mouse1.18012855
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17402415
74RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17386132
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17350418
76RNF2_27304074_Chip-Seq_NSC_Mouse1.16223935
77* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.15467149
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11218748
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09371809
80CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08636595
81PU1_27457419_Chip-Seq_LIVER_Mouse1.08611576
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.07535099
83REST_21632747_ChIP-Seq_MESCs_Mouse1.06337599
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06290917
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.04462929
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03862586
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02567334
88MYC_27129775_Chip-Seq_CORNEA_Mouse1.01271914
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.00907170
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.00639269
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.00086441
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99406252
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99104129
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98087793
95SOX9_26525672_Chip-Seq_HEART_Mouse0.97567760
96GF1_26923725_Chip-Seq_HPCs_Mouse0.96908018
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96809813
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.96378777
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91454588
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91258837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06931475
2MP0001929_abnormal_gametogenesis5.53294018
3MP0008877_abnormal_DNA_methylation3.53506342
4MP0002161_abnormal_fertility/fecundity3.33816814
5MP0002210_abnormal_sex_determination3.33280959
6MP0001145_abnormal_male_reproductive3.00099841
7MP0000653_abnormal_sex_gland2.47345149
8MP0005670_abnormal_white_adipose2.46322005
9MP0002653_abnormal_ependyma_morphology2.36839675
10MP0005410_abnormal_fertilization15.6536688
11MP0001765_abnormal_ion_homeostasis1.75770672
12MP0005623_abnormal_meninges_morphology1.59966545
13MP0003195_calcinosis1.53342937
14MP0005647_abnormal_sex_gland1.48990773
15MP0002139_abnormal_hepatobiliary_system1.48893833
16MP0004043_abnormal_pH_regulation1.48416321
17MP0008995_early_reproductive_senescence1.33417180
18MP0004233_abnormal_muscle_weight1.33072782
19MP0002160_abnormal_reproductive_system1.26189745
20MP0002282_abnormal_trachea_morphology1.18074219
21MP0005636_abnormal_mineral_homeostasis1.07035980
22MP0002909_abnormal_adrenal_gland1.06045832
23MP0005389_reproductive_system_phenotype0.88252872
24MP0003329_amyloid_beta_deposits0.87930078
25MP0002254_reproductive_system_inflammat0.86626058
26MP0001984_abnormal_olfaction0.85877268
27MP0003303_peritoneal_inflammation0.85793574
28MP0001661_extended_life_span0.80433037
29MP0002234_abnormal_pharynx_morphology0.80316348
30MP0009046_muscle_twitch0.66054287
31MP0004036_abnormal_muscle_relaxation0.65423781
32MP0002168_other_aberrant_phenotype0.65357929
33MP0003315_abnormal_perineum_morphology0.64515434
34MP0005666_abnormal_adipose_tissue0.63994992
35MP0010329_abnormal_lipoprotein_level0.63798736
36MP0005187_abnormal_penis_morphology0.62940357
37MP0000534_abnormal_ureter_morphology0.59255079
38MP0003878_abnormal_ear_physiology0.57822133
39MP0005377_hearing/vestibular/ear_phenot0.57822133
40MP0002009_preneoplasia0.55677981
41MP0005365_abnormal_bile_salt0.54765601
42MP0002269_muscular_atrophy0.54746146
43MP0003699_abnormal_female_reproductive0.54688043
44MP0003115_abnormal_respiratory_system0.54549448
45MP0000604_amyloidosis0.53843110
46MP0004145_abnormal_muscle_electrophysio0.51599183
47MP0002736_abnormal_nociception_after0.49841222
48MP0004019_abnormal_vitamin_homeostasis0.49736415
49MP0002971_abnormal_brown_adipose0.49523219
50MP0001119_abnormal_female_reproductive0.48161809
51MP0000639_abnormal_adrenal_gland0.47911227
52MP0003950_abnormal_plasma_membrane0.46214434
53MP0008058_abnormal_DNA_repair0.45116056
54MP0000358_abnormal_cell_content/0.44306874
55MP0002118_abnormal_lipid_homeostasis0.43965718
56MP0001919_abnormal_reproductive_system0.43723290
57MP0004130_abnormal_muscle_cell0.43425569
58MP0005319_abnormal_enzyme/_coenzyme0.42699405
59MP0003011_delayed_dark_adaptation0.42652167
60MP0009115_abnormal_fat_cell0.42437379
61MP0002928_abnormal_bile_duct0.41976766
62MP0005375_adipose_tissue_phenotype0.39536839
63MP0001324_abnormal_eye_pigmentation0.39180106
64MP0003633_abnormal_nervous_system0.37511195
65MP0004084_abnormal_cardiac_muscle0.37460156
66MP0008875_abnormal_xenobiotic_pharmacok0.37213026
67MP0001764_abnormal_homeostasis0.36963134
68MP0005253_abnormal_eye_physiology0.36585699
69MP0005551_abnormal_eye_electrophysiolog0.35425023
70MP0005275_abnormal_skin_tensile0.34309996
71MP0003646_muscle_fatigue0.34035451
72MP0010234_abnormal_vibrissa_follicle0.33527210
73MP0003300_gastrointestinal_ulcer0.33076179
74MP0003953_abnormal_hormone_level0.30120981
75MP0002102_abnormal_ear_morphology0.28880974
76MP0005388_respiratory_system_phenotype0.27784940
77MP0002133_abnormal_respiratory_system0.27784940
78MP0001440_abnormal_grooming_behavior0.27676251
79MP0003631_nervous_system_phenotype0.27498855
80MP0002796_impaired_skin_barrier0.26771703
81MP0003705_abnormal_hypodermis_morpholog0.26049023
82MP0006036_abnormal_mitochondrial_physio0.25617918
83MP0006035_abnormal_mitochondrial_morpho0.24109296
84MP0005334_abnormal_fat_pad0.24045200
85MP0002295_abnormal_pulmonary_circulatio0.23884972
86MP0005391_vision/eye_phenotype0.22853835
87MP0005584_abnormal_enzyme/coenzyme_acti0.22689862
88MP0001968_abnormal_touch/_nociception0.21982184
89MP0009384_cardiac_valve_regurgitation0.21712703
90MP0003942_abnormal_urinary_system0.20877547
91MP0009643_abnormal_urine_homeostasis0.20589147
92MP0003936_abnormal_reproductive_system0.20160530
93MP0005085_abnormal_gallbladder_physiolo0.20120917
94MP0000462_abnormal_digestive_system0.19564440
95MP0005535_abnormal_body_temperature0.19298828
96MP0000609_abnormal_liver_physiology0.19091156
97MP0001849_ear_inflammation0.18567856
98MP0000537_abnormal_urethra_morphology0.18018072
99MP0000631_abnormal_neuroendocrine_gland0.17691964
100MP0009642_abnormal_blood_homeostasis0.17621087

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.06696627
2Abnormal respiratory motile cilium morphology (HP:0005938)9.06696627
3Abnormal respiratory motile cilium physiology (HP:0012261)9.04077531
4Chronic bronchitis (HP:0004469)7.49797739
5Abnormal ciliary motility (HP:0012262)7.45634550
6Rhinitis (HP:0012384)7.15264001
7Infertility (HP:0000789)6.82921266
8Nasal polyposis (HP:0100582)6.17506085
9Abnormality of the nasal mucosa (HP:0000433)5.15837197
10Male infertility (HP:0003251)5.00067815
11Gonadotropin excess (HP:0000837)4.37261024
12Bronchitis (HP:0012387)4.35838143
13Bronchiectasis (HP:0002110)4.20313405
14Abnormal spermatogenesis (HP:0008669)3.63216046
15Recurrent sinusitis (HP:0011108)3.45154734
16Nephronophthisis (HP:0000090)3.43308306
17Recurrent otitis media (HP:0000403)3.01800562
18Azoospermia (HP:0000027)2.91581987
19Tubulointerstitial nephritis (HP:0001970)2.77464794
20Medial flaring of the eyebrow (HP:0010747)2.65818110
21Abnormality of the renal medulla (HP:0100957)2.61492719
22Tubular atrophy (HP:0000092)2.47315773
23Tubulointerstitial abnormality (HP:0001969)2.33762527
24Asymmetric septal hypertrophy (HP:0001670)2.30107452
25Recurrent bronchitis (HP:0002837)2.26531745
26Molar tooth sign on MRI (HP:0002419)2.24444203
27Abnormality of midbrain morphology (HP:0002418)2.24444203
28Vascular calcification (HP:0004934)2.19607829
29Cardiovascular calcification (HP:0011915)2.02411045
30Absent/shortened dynein arms (HP:0200106)13.2847764
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.2847764
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7104250
33Tubulointerstitial fibrosis (HP:0005576)1.94936308
34Muscle fibrillation (HP:0010546)1.92956820
35Choroideremia (HP:0001139)1.88999706
36Tongue fasciculations (HP:0001308)1.88168576
37Gait imbalance (HP:0002141)1.79133298
38Congenital primary aphakia (HP:0007707)1.77616909
39Chronic sinusitis (HP:0011109)1.73573034
40Stage 5 chronic kidney disease (HP:0003774)1.71995458
41Bundle branch block (HP:0011710)1.68744192
42Abnormal gallbladder physiology (HP:0012438)1.65958554
43Cholecystitis (HP:0001082)1.65958554
44Hemorrhage of the eye (HP:0011885)1.63258490
45Abnormality of renal excretion (HP:0011036)1.62071792
46Neurofibrillary tangles (HP:0002185)1.61483983
47Potter facies (HP:0002009)1.59548300
48Facial shape deformation (HP:0011334)1.59548300
49Impulsivity (HP:0100710)1.59523340
50Heterotopia (HP:0002282)1.58800174
51Abnormality of saccadic eye movements (HP:0000570)1.58308812
52Abnormality of permanent molar morphology (HP:0011071)1.56969330
53Abnormality of the dental root (HP:0006486)1.56969330
54Taurodontia (HP:0000679)1.56969330
55Dyschromatopsia (HP:0007641)1.55776994
56Hyperpituitarism (HP:0010514)1.50297362
57Abnormality of molar (HP:0011077)1.50116890
58Abnormality of molar morphology (HP:0011070)1.50116890
59Decreased central vision (HP:0007663)1.47243956
60Postaxial foot polydactyly (HP:0001830)1.47192646
61Sensory axonal neuropathy (HP:0003390)1.46274028
62Neoplasm of the heart (HP:0100544)1.44753193
63Optic nerve hypoplasia (HP:0000609)1.44459378
64Nephrogenic diabetes insipidus (HP:0009806)1.44212036
65Abnormality of the renal cortex (HP:0011035)1.43857810
66Menstrual irregularities (HP:0000858)1.43534969
67Cerebral inclusion bodies (HP:0100314)1.43084573
68Abnormality of the dental pulp (HP:0006479)1.42250354
69Abnormality of dentin (HP:0010299)1.41983492
70Aplasia/Hypoplasia of the lens (HP:0008063)1.41833653
71Vaginal atresia (HP:0000148)1.40953521
72Hyporeflexia of lower limbs (HP:0002600)1.39597306
73Genital tract atresia (HP:0001827)1.38714865
74Short ribs (HP:0000773)1.35961430
75Hyperphosphatemia (HP:0002905)1.35653208
76Impaired smooth pursuit (HP:0007772)1.35360910
77Postaxial hand polydactyly (HP:0001162)1.33905074
78Renovascular hypertension (HP:0100817)1.33148238
79Spastic tetraparesis (HP:0001285)1.31014783
80Cystic liver disease (HP:0006706)1.30585694
81Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30494472
82Congenital hepatic fibrosis (HP:0002612)1.30327491
83Bell-shaped thorax (HP:0001591)1.30217935
84Abnormality of ocular smooth pursuit (HP:0000617)1.28918409
85Poor coordination (HP:0002370)1.23882922
86Fibular hypoplasia (HP:0003038)1.22955875
87Abnormal biliary tract physiology (HP:0012439)1.21980316
88Bile duct proliferation (HP:0001408)1.21980316
89Oculomotor apraxia (HP:0000657)1.20591445
90Subcapsular cataract (HP:0000523)1.19935184
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.19591300
92Truncal obesity (HP:0001956)1.19484844
93Male pseudohermaphroditism (HP:0000037)1.19273458
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18055088
95Epidermoid cyst (HP:0200040)1.16561476
96Constricted visual fields (HP:0001133)1.15953883
97Polydipsia (HP:0001959)1.15908973
98Abnormal drinking behavior (HP:0030082)1.15908973
99Papillary thyroid carcinoma (HP:0002895)1.14522018
100Polycystic ovaries (HP:0000147)1.13932013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.74486392
2PDK39.74486392
3PDK26.36344023
4TESK13.82654242
5PRKD32.97137303
6ICK2.84486216
7WNK41.83226964
8PTK2B1.76364189
9STK391.74921684
10LMTK21.66084089
11STK381.14383546
12PDK11.13300038
13PNCK1.11292705
14DYRK1B1.07032503
15NEK20.99881784
16IRAK10.95094217
17TYRO30.86484200
18RIPK40.63000011
19TRIB30.61405820
20WNK10.57764911
21PDPK10.55232066
22STK38L0.54909942
23MAP2K60.52498619
24STK30.48293774
25EEF2K0.44989426
26IRAK20.44902046
27DYRK30.44684700
28PASK0.42741380
29CAMK1G0.41505846
30PAK10.41236971
31CHEK20.38295033
32FGFR20.36016865
33CCNB10.34040250
34ERN10.33831841
35TTK0.32632707
36FER0.29501489
37PRKCG0.29414219
38MAPK150.28970577
39PAK20.28251268
40PLK40.27418941
41CHEK10.25802414
42RIPK10.25665456
43LATS10.24536899
44CDK120.23231098
45PDGFRB0.22097652
46PTK60.21813562
47STK100.21470139
48PRKCZ0.21263495
49EPHB10.21261748
50CDK60.20668856
51NTRK20.20517217
52YES10.19785312
53PDGFRA0.19563323
54MTOR0.19557548
55PINK10.18548924
56PRKG20.18323387
57PIK3CG0.18050705
58TESK20.17303202
59PAK40.17227922
60GSK3A0.16854220
61TTN0.15394299
62MAP3K100.14518397
63PRKACG0.12172452
64PRKCQ0.12118690
65ATM0.11855022
66MYLK0.11766668
67INSR0.11663173
68BRSK20.09872722
69EGFR0.09129692
70CDK150.08073695
71MAP3K20.08056440
72LRRK20.07829946
73CAMKK10.07657642
74PRKAA10.07257934
75MST40.07089351
76CDK40.06370219
77RPS6KB10.06116773
78RET0.06047964
79PRKG10.05978980
80CDK140.05732055
81FRK0.05715710
82MUSK0.05222473
83PKN10.04876308
84CDK180.04763866
85CSNK1E0.04607545
86CDK11A0.04437351
87RPS6KA30.04174260
88RPS6KA10.03048360
89SRC0.02949197
90CSNK2A10.02900409
91GSK3B0.02834635
92NEK60.02725956
93IGF1R0.02658645
94DDR20.02607631
95PRKCA0.02605091
96CSNK2A20.02031025
97PRKCD0.01549777
98ZAP700.01505331
99PRKACB0.01416064
100MAPKAPK50.01344345

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.68688909
2Fatty acid biosynthesis_Homo sapiens_hsa000613.55420776
3Pyruvate metabolism_Homo sapiens_hsa006203.48593186
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.13513769
5Vitamin B6 metabolism_Homo sapiens_hsa007502.99447261
6Glutathione metabolism_Homo sapiens_hsa004802.98966430
7Propanoate metabolism_Homo sapiens_hsa006402.74961329
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63247750
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47694194
10Thyroid hormone synthesis_Homo sapiens_hsa049182.22506264
11Arachidonic acid metabolism_Homo sapiens_hsa005902.22067769
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.17878220
13PPAR signaling pathway_Homo sapiens_hsa033202.12361845
14Glucagon signaling pathway_Homo sapiens_hsa049222.09679249
15Glycerolipid metabolism_Homo sapiens_hsa005612.08014714
16Linoleic acid metabolism_Homo sapiens_hsa005912.02249275
17Fatty acid degradation_Homo sapiens_hsa000711.90800137
18Ovarian steroidogenesis_Homo sapiens_hsa049131.89095954
19Fatty acid metabolism_Homo sapiens_hsa012121.86704584
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78023922
21Selenocompound metabolism_Homo sapiens_hsa004501.59964841
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59880536
23Oocyte meiosis_Homo sapiens_hsa041141.58790084
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.55358130
25Carbon metabolism_Homo sapiens_hsa012001.51527330
26Nitrogen metabolism_Homo sapiens_hsa009101.45167562
27Fat digestion and absorption_Homo sapiens_hsa049751.45070105
28Pentose phosphate pathway_Homo sapiens_hsa000301.43883293
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39018134
30Mineral absorption_Homo sapiens_hsa049781.35764100
31Sulfur metabolism_Homo sapiens_hsa009201.35205631
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30754616
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23398381
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19153658
35Tryptophan metabolism_Homo sapiens_hsa003801.17575824
36Renin secretion_Homo sapiens_hsa049241.16596980
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14182745
38Basal transcription factors_Homo sapiens_hsa030221.13691205
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12767156
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.11925728
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07705314
42Collecting duct acid secretion_Homo sapiens_hsa049661.07647844
43African trypanosomiasis_Homo sapiens_hsa051431.06874588
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05230139
45Bile secretion_Homo sapiens_hsa049761.05081554
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03131036
47Amphetamine addiction_Homo sapiens_hsa050311.01067567
48Biosynthesis of amino acids_Homo sapiens_hsa012300.91652235
49Chemical carcinogenesis_Homo sapiens_hsa052040.88672377
50Salivary secretion_Homo sapiens_hsa049700.86991749
51Estrogen signaling pathway_Homo sapiens_hsa049150.86537877
52Cardiac muscle contraction_Homo sapiens_hsa042600.86189629
53Dorso-ventral axis formation_Homo sapiens_hsa043200.84978990
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.84882350
55Ether lipid metabolism_Homo sapiens_hsa005650.82077843
56Gastric acid secretion_Homo sapiens_hsa049710.81087006
57Fructose and mannose metabolism_Homo sapiens_hsa000510.80022560
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78393010
59Renin-angiotensin system_Homo sapiens_hsa046140.75740518
60Antigen processing and presentation_Homo sapiens_hsa046120.72521036
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67862978
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.65879969
63Insulin secretion_Homo sapiens_hsa049110.62953352
64Inositol phosphate metabolism_Homo sapiens_hsa005620.62715630
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61412467
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.59363977
67Long-term potentiation_Homo sapiens_hsa047200.59069870
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58829289
69Protein digestion and absorption_Homo sapiens_hsa049740.57727703
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55728543
71Calcium signaling pathway_Homo sapiens_hsa040200.51528459
72N-Glycan biosynthesis_Homo sapiens_hsa005100.51038182
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50199219
74Hedgehog signaling pathway_Homo sapiens_hsa043400.47716833
75Purine metabolism_Homo sapiens_hsa002300.47521913
76Huntingtons disease_Homo sapiens_hsa050160.47358593
77Pancreatic secretion_Homo sapiens_hsa049720.46373832
78Synaptic vesicle cycle_Homo sapiens_hsa047210.44174049
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.43828704
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42289738
81Circadian entrainment_Homo sapiens_hsa047130.41187312
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40766086
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40722235
84cAMP signaling pathway_Homo sapiens_hsa040240.39969773
85Metabolic pathways_Homo sapiens_hsa011000.39606440
86AMPK signaling pathway_Homo sapiens_hsa041520.39141448
87mRNA surveillance pathway_Homo sapiens_hsa030150.38807264
88Complement and coagulation cascades_Homo sapiens_hsa046100.35814134
89ABC transporters_Homo sapiens_hsa020100.30717273
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26500512
91Endocytosis_Homo sapiens_hsa041440.24281358
92Legionellosis_Homo sapiens_hsa051340.23594000
93Taste transduction_Homo sapiens_hsa047420.23351141
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23231667
95Vibrio cholerae infection_Homo sapiens_hsa051100.23142406
96VEGF signaling pathway_Homo sapiens_hsa043700.16553398
97Phenylalanine metabolism_Homo sapiens_hsa003600.16416038
98Tight junction_Homo sapiens_hsa045300.15443451
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15161301
100Systemic lupus erythematosus_Homo sapiens_hsa053220.14943183

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »