CST9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sex determination (GO:0007530)9.93817733
2regulation of meiosis I (GO:0060631)9.77381607
3fusion of sperm to egg plasma membrane (GO:0007342)9.23170431
4regulation of male gonad development (GO:2000018)9.18776132
5male meiosis (GO:0007140)8.78259446
6synaptonemal complex assembly (GO:0007130)8.74549215
7synaptonemal complex organization (GO:0070193)8.64376466
8sex differentiation (GO:0007548)8.47464390
9DNA methylation involved in gamete generation (GO:0043046)7.76433161
10plasma membrane fusion (GO:0045026)6.89384729
11male sex determination (GO:0030238)6.31370069
12anatomical structure regression (GO:0060033)5.95969572
13male meiosis I (GO:0007141)5.90034371
14oocyte development (GO:0048599)5.65149060
15regulation of gonadotropin secretion (GO:0032276)5.63389523
16glomerular basement membrane development (GO:0032836)5.60314193
17chromosome organization involved in meiosis (GO:0070192)5.51006925
18meiotic nuclear division (GO:0007126)5.43989086
19spermatid development (GO:0007286)5.29476999
20cilium or flagellum-dependent cell motility (GO:0001539)5.04404618
21astrocyte development (GO:0014002)4.79933090
22Leydig cell differentiation (GO:0033327)4.79696862
23regulation of female gonad development (GO:2000194)4.75897302
24meiosis I (GO:0007127)4.72344071
25gene silencing by RNA (GO:0031047)4.64743182
26positive regulation of meiosis (GO:0045836)4.64507657
27sperm motility (GO:0030317)4.55995960
28negative regulation of meiosis (GO:0045835)4.55126508
29germ cell development (GO:0007281)4.43841642
30positive regulation of meiotic cell cycle (GO:0051446)4.32888028
31ovulation cycle (GO:0042698)4.23878525
32seminiferous tubule development (GO:0072520)4.23123563
33poly(A)+ mRNA export from nucleus (GO:0016973)4.15036138
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.14211657
35macroautophagy (GO:0016236)3.97970758
36acrosome assembly (GO:0001675)3.94356905
37negative regulation of macrophage differentiation (GO:0045650)3.85390722
38spermatogenesis (GO:0007283)3.77534095
39sperm-egg recognition (GO:0035036)3.76726594
40male gamete generation (GO:0048232)3.76254821
41axonemal dynein complex assembly (GO:0070286)3.67364150
42positive regulation of reproductive process (GO:2000243)3.67268611
43binding of sperm to zona pellucida (GO:0007339)3.63624441
44DNA alkylation (GO:0006305)3.61342820
45DNA methylation (GO:0006306)3.61342820
46meiotic cell cycle (GO:0051321)3.60378898
47response to misfolded protein (GO:0051788)3.56061609
48genitalia morphogenesis (GO:0035112)3.51373512
49gamete generation (GO:0007276)3.48600528
50oogenesis (GO:0048477)3.43596044
51female gamete generation (GO:0007292)3.41471585
52meiotic cell cycle process (GO:1903046)3.39473429
53gene silencing (GO:0016458)3.38820718
54multicellular organism reproduction (GO:0032504)3.29587735
55nuclear pore complex assembly (GO:0051292)3.29486616
56cell-cell recognition (GO:0009988)3.28888018
57epithelial cilium movement (GO:0003351)3.28300818
58regulation of protein polyubiquitination (GO:1902914)3.22850155
59diaphragm development (GO:0060539)3.22121518
60hemoglobin metabolic process (GO:0020027)3.18467987
61acrosome reaction (GO:0007340)3.14589303
62apoptotic cell clearance (GO:0043277)3.13021608
63germ cell migration (GO:0008354)3.10848442
64Sertoli cell development (GO:0060009)3.08778459
65negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.08441619
66embryonic foregut morphogenesis (GO:0048617)3.03069399
67motile cilium assembly (GO:0044458)3.02532242
68regulation of nucleobase-containing compound transport (GO:0032239)2.99923684
69histone H4-K5 acetylation (GO:0043981)2.97339617
70histone H4-K8 acetylation (GO:0043982)2.97339617
71fertilization (GO:0009566)2.93114242
72adrenal gland development (GO:0030325)2.92230893
73regulation of meiosis (GO:0040020)2.91298334
74negative regulation of DNA repair (GO:0045738)2.90282768
75skeletal muscle organ development (GO:0060538)2.87845997
76male genitalia development (GO:0030539)2.87126817
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85148156
78glial cell proliferation (GO:0014009)2.84089799
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82725903
80multicellular organismal reproductive process (GO:0048609)2.80961166
81nuclear pore organization (GO:0006999)2.78859344
82cellular response to gonadotropin stimulus (GO:0071371)2.78016865
83peptidyl-lysine dimethylation (GO:0018027)2.77665514
84androgen biosynthetic process (GO:0006702)2.77363871
85receptor guanylyl cyclase signaling pathway (GO:0007168)2.73633077
86histone H2A acetylation (GO:0043968)2.72143251
87negative regulation of inclusion body assembly (GO:0090084)2.70470092
88regulation of inclusion body assembly (GO:0090083)2.68640351
89cilium movement (GO:0003341)2.68408113
90regulation of microtubule-based movement (GO:0060632)2.67724568
91reproduction (GO:0000003)2.65258898
92urogenital system development (GO:0001655)2.63675527
93negative regulation of meiotic cell cycle (GO:0051447)2.63302962
94glomerulus development (GO:0032835)2.63212322
95fat-soluble vitamin catabolic process (GO:0042363)2.60155795
96vitamin catabolic process (GO:0009111)2.60155795
97ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57716216
98gonadal mesoderm development (GO:0007506)17.8825494
99piRNA metabolic process (GO:0034587)11.4516217
100positive regulation of male gonad development (GO:2000020)10.5377142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.34591682
2STAT6_21828071_ChIP-Seq_BEAS2B_Human8.03447602
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.22853555
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.16608030
5ZNF263_19887448_ChIP-Seq_K562_Human2.92658671
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.78549750
7CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.31230258
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26142506
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26142506
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26142506
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.09483884
12CLOCK_20551151_ChIP-Seq_293T_Human1.94745360
13TCF7_22412390_ChIP-Seq_EML_Mouse1.93951976
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89266316
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82316556
16KDM2B_26808549_Chip-Seq_DND41_Human1.70702339
17RNF2_27304074_Chip-Seq_NSC_Mouse1.68004872
18RUNX1_27514584_Chip-Seq_MCF-7_Human1.67029399
19TP53_22127205_ChIP-Seq_IMR90_Human1.61074943
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59203183
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56369895
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55029301
23KDM2B_26808549_Chip-Seq_K562_Human1.46624569
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44582322
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41476718
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40842125
27OCT4_19829295_ChIP-Seq_ESCs_Human1.39948326
28CREB1_26743006_Chip-Seq_LNCaP_Human1.36989287
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.36565010
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32107596
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31884593
32NCOR1_26117541_ChIP-Seq_K562_Human1.24490376
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24116532
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22983714
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20384504
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19040894
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18544159
38ZNF274_21170338_ChIP-Seq_K562_Hela1.17909382
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12550768
40* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12404692
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11339029
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.11043771
43EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08421295
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08026044
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05846780
46RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05749892
47MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05074068
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04912619
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04293646
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03853591
51EZH2_22144423_ChIP-Seq_EOC_Human1.03651162
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.02921816
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.02857243
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02153493
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02001085
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.01394054
57MYC_27129775_Chip-Seq_CORNEA_Mouse1.00019736
58TET1_21490601_ChIP-Seq_MESCs_Mouse0.99673551
59BCAT_22108803_ChIP-Seq_LS180_Human0.99302035
60ESR1_21235772_ChIP-Seq_MCF-7_Human0.98772931
61ISL1_27105846_Chip-Seq_CPCs_Mouse0.97813729
62CHD1_26751641_Chip-Seq_LNCaP_Human0.96518129
63CTCF_27219007_Chip-Seq_Bcells_Human0.95910345
64TBX20_22328084_ChIP-Seq_HEART_Mouse0.95755173
65TBX20_22080862_ChIP-Seq_HEART_Mouse0.95755173
66SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95398720
67RNF2_27304074_Chip-Seq_ESCs_Mouse0.95343405
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94238880
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94015828
70* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93762547
71SMAD3_21741376_ChIP-Seq_ESCs_Human0.93458027
72SMC4_20622854_ChIP-Seq_HELA_Human0.92554327
73SA1_27219007_Chip-Seq_ERYTHROID_Human0.90912624
74CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90540613
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89609962
76PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89177378
77KLF4_19829295_ChIP-Seq_ESCs_Human0.88902573
78SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88856846
79FOXA2_19822575_ChIP-Seq_HepG2_Human0.87951960
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87259224
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86935150
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86445532
83RACK7_27058665_Chip-Seq_MCF-7_Human0.85573785
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85555493
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84192988
86* SOX2_21211035_ChIP-Seq_LN229_Human0.84186175
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83116491
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82780667
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.82474033
90FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81661041
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81327494
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80916027
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79686377
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79211139
95CTCF_21964334_Chip-Seq_Bcells_Human0.75630080
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.75587681
97EP300_21415370_ChIP-Seq_HL-1_Mouse0.75522405
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.74571139
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74479801
100SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72567267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.55084506
2MP0008877_abnormal_DNA_methylation7.00005707
3MP0005410_abnormal_fertilization5.36430270
4MP0005377_hearing/vestibular/ear_phenot5.20688785
5MP0003878_abnormal_ear_physiology5.20688785
6MP0002210_abnormal_sex_determination3.33143504
7MP0001929_abnormal_gametogenesis3.32069726
8MP0003195_calcinosis3.28579121
9MP0003786_premature_aging3.24567276
10MP0003698_abnormal_male_reproductive3.06992133
11MP0001145_abnormal_male_reproductive2.86054595
12MP0001661_extended_life_span2.52571435
13MP0000653_abnormal_sex_gland2.39718364
14MP0005647_abnormal_sex_gland2.38980055
15MP0003879_abnormal_hair_cell2.28695227
16MP0003045_fibrosis2.20729619
17MP0001727_abnormal_embryo_implantation1.96499719
18MP0003315_abnormal_perineum_morphology1.96427715
19MP0002160_abnormal_reproductive_system1.96196451
20MP0009278_abnormal_bone_marrow1.91203682
21MP0005623_abnormal_meninges_morphology1.87293980
22MP0009384_cardiac_valve_regurgitation1.80278629
23MP0004272_abnormal_basement_membrane1.75180485
24MP0001958_emphysema1.69973252
25MP0002161_abnormal_fertility/fecundity1.66945252
26MP0002102_abnormal_ear_morphology1.62550726
27MP0000751_myopathy1.57543664
28MP0003115_abnormal_respiratory_system1.54498982
29MP0003936_abnormal_reproductive_system1.46966124
30MP0002168_other_aberrant_phenotype1.45288926
31MP0000569_abnormal_digit_pigmentation1.44565255
32MP0003123_paternal_imprinting1.33260181
33MP0005389_reproductive_system_phenotype1.30748963
34MP0000537_abnormal_urethra_morphology1.26388234
35MP0004084_abnormal_cardiac_muscle1.26331249
36MP0002653_abnormal_ependyma_morphology1.16842071
37MP0005076_abnormal_cell_differentiation1.13630247
38MP0008057_abnormal_DNA_replication1.12832520
39MP0004742_abnormal_vestibular_system1.09800860
40MP0006138_congestive_heart_failure1.08982951
41MP0004147_increased_porphyrin_level1.05813864
42MP0000639_abnormal_adrenal_gland1.02926009
43MP0004036_abnormal_muscle_relaxation1.00997455
44MP0001440_abnormal_grooming_behavior0.97679874
45MP0005670_abnormal_white_adipose0.96639334
46MP0003942_abnormal_urinary_system0.96235013
47MP0001119_abnormal_female_reproductive0.93916017
48MP0004885_abnormal_endolymph0.85450288
49MP0008438_abnormal_cutaneous_collagen0.84916077
50MP0003866_abnormal_defecation0.78562851
51MP0003119_abnormal_digestive_system0.77571237
52MP0005395_other_phenotype0.76169811
53MP0003300_gastrointestinal_ulcer0.75920827
54MP0009780_abnormal_chondrocyte_physiolo0.74986233
55MP0005167_abnormal_blood-brain_barrier0.74193027
56MP0001919_abnormal_reproductive_system0.72030220
57MP0004134_abnormal_chest_morphology0.70067145
58MP0004233_abnormal_muscle_weight0.69608636
59MP0002282_abnormal_trachea_morphology0.68822977
60MP0004145_abnormal_muscle_electrophysio0.68699699
61MP0001851_eye_inflammation0.68685592
62MP0003699_abnormal_female_reproductive0.68095118
63MP0005503_abnormal_tendon_morphology0.67921027
64MP0004197_abnormal_fetal_growth/weight/0.67635987
65MP0001730_embryonic_growth_arrest0.64772645
66MP0003121_genomic_imprinting0.62791642
67MP0000428_abnormal_craniofacial_morphol0.62312657
68MP0003787_abnormal_imprinting0.61345446
69MP0003283_abnormal_digestive_organ0.61150971
70MP0005171_absent_coat_pigmentation0.60020864
71MP0010307_abnormal_tumor_latency0.59481494
72MP0005397_hematopoietic_system_phenotyp0.57128725
73MP0001545_abnormal_hematopoietic_system0.57128725
74MP0003091_abnormal_cell_migration0.56397657
75MP0000427_abnormal_hair_cycle0.56181618
76MP0008007_abnormal_cellular_replicative0.55300872
77MP0005408_hypopigmentation0.54309237
78MP0002084_abnormal_developmental_patter0.54034329
79MP0005248_abnormal_Harderian_gland0.53536670
80MP0002295_abnormal_pulmonary_circulatio0.49658107
81MP0008961_abnormal_basal_metabolism0.49262885
82MP0000631_abnormal_neuroendocrine_gland0.47868230
83MP0004808_abnormal_hematopoietic_stem0.43628093
84MP0002128_abnormal_blood_circulation0.43446310
85MP0000534_abnormal_ureter_morphology0.42890269
86MP0004957_abnormal_blastocyst_morpholog0.41046761
87MP0003111_abnormal_nucleus_morphology0.38524892
88MP0003705_abnormal_hypodermis_morpholog0.38434415
89MP0009672_abnormal_birth_weight0.38348427
90MP0002086_abnormal_extraembryonic_tissu0.37245149
91MP0002009_preneoplasia0.37082629
92MP0010094_abnormal_chromosome_stability0.36557466
93MP0002090_abnormal_vision0.36538696
94MP0003632_abnormal_nervous_system0.36082837
95MP0000470_abnormal_stomach_morphology0.35990555
96MP0002108_abnormal_muscle_morphology0.33982306
97MP0009703_decreased_birth_body0.33928967
98MP0002085_abnormal_embryonic_tissue0.33697435
99MP0002896_abnormal_bone_mineralization0.33402638
100MP0003567_abnormal_fetal_cardiomyocyte0.32599006

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.48595640
2Gonadotropin excess (HP:0000837)7.86338503
3Male pseudohermaphroditism (HP:0000037)6.39479790
4Testicular neoplasm (HP:0010788)5.68640404
5Abnormal sex determination (HP:0012244)5.63004196
6Sex reversal (HP:0012245)5.63004196
7Infertility (HP:0000789)5.59186146
8Azoospermia (HP:0000027)5.54006065
9Abnormality of male internal genitalia (HP:0000022)4.94970180
10Abnormal spermatogenesis (HP:0008669)4.68258257
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.65947799
1211 pairs of ribs (HP:0000878)4.58337435
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.38426326
14Absent/shortened dynein arms (HP:0200106)4.38426326
15Hand muscle atrophy (HP:0009130)4.31244675
16Abnormality of the lower motor neuron (HP:0002366)3.95970728
17Facial diplegia (HP:0001349)3.80988236
18Germ cell neoplasia (HP:0100728)3.66843440
19Mesangial abnormality (HP:0001966)3.64772678
20Hypoplasia of the uterus (HP:0000013)3.47770399
21Ankle clonus (HP:0011448)3.44462988
22Distal upper limb amyotrophy (HP:0007149)3.42416276
23Upper limb amyotrophy (HP:0009129)3.42416276
24Metaphyseal cupping (HP:0003021)3.38370259
25Tongue fasciculations (HP:0001308)3.28754190
26Secondary amenorrhea (HP:0000869)3.27344005
27Stridor (HP:0010307)3.23982682
28Ankle contracture (HP:0006466)3.11366313
29Rectal prolapse (HP:0002035)3.02397057
30Muscle fibrillation (HP:0010546)2.96398705
31Diaphragmatic weakness (HP:0009113)2.90363692
32Abnormal respiratory motile cilium physiology (HP:0012261)2.89863575
33Missing ribs (HP:0000921)2.87588378
34Hypoplastic left heart (HP:0004383)2.81118616
35Rhinitis (HP:0012384)2.76631287
36Occipital encephalocele (HP:0002085)2.76432791
37Bladder diverticulum (HP:0000015)2.71001698
38Stage 5 chronic kidney disease (HP:0003774)2.67848852
39Abnormal respiratory epithelium morphology (HP:0012253)2.64901628
40Abnormal respiratory motile cilium morphology (HP:0005938)2.64901628
41Fibular hypoplasia (HP:0003038)2.58696242
42Primary amenorrhea (HP:0000786)2.55203438
43Renovascular hypertension (HP:0100817)2.49970185
44Nasal polyposis (HP:0100582)2.49537684
45Pulmonary fibrosis (HP:0002206)2.48140696
46Hypoventilation (HP:0002791)2.45317650
47Polycystic ovaries (HP:0000147)2.45136378
48Chronic bronchitis (HP:0004469)2.40091547
49Clumsiness (HP:0002312)2.35680270
50Abnormality of the vocal cords (HP:0008777)2.29505458
51Abnormality of the musculature of the hand (HP:0001421)2.28232615
52Transposition of the great arteries (HP:0001669)2.27169096
53Abnormal connection of the cardiac segments (HP:0011545)2.27169096
54Abnormal ventriculo-arterial connection (HP:0011563)2.27169096
55Aplasia/hypoplasia of the uterus (HP:0008684)2.25733064
56Clonus (HP:0002169)2.24176924
57Abnormality of the nasal mucosa (HP:0000433)2.17313680
58Abnormality of dentin (HP:0010299)2.15522644
59Selective tooth agenesis (HP:0001592)2.15076442
60Nephronophthisis (HP:0000090)2.13610523
61Nausea (HP:0002018)2.11294973
62Myopathic facies (HP:0002058)2.10584123
63Amyotrophic lateral sclerosis (HP:0007354)2.05135814
64Premature ovarian failure (HP:0008209)2.02281720
65Protrusio acetabuli (HP:0003179)2.01509224
66Male infertility (HP:0003251)10.4758968
67Hyperacusis (HP:0010780)1.99691477
68Hypoplastic heart (HP:0001961)1.98162691
69Abnormal ciliary motility (HP:0012262)1.93478096
70Oligodactyly (HP:0012165)1.86549962
71Hyperpituitarism (HP:0010514)1.83624618
72Cerebral aneurysm (HP:0004944)1.83381746
73Follicular hyperkeratosis (HP:0007502)1.83137270
74Pulmonary artery stenosis (HP:0004415)1.80946037
75Ovarian neoplasm (HP:0100615)1.77927511
76Arachnodactyly (HP:0001166)1.74549235
77Insomnia (HP:0100785)1.73886785
78Renal duplication (HP:0000075)1.72892180
79Overriding aorta (HP:0002623)1.70637756
80Lymphangioma (HP:0100764)1.69494801
81Fasciculations (HP:0002380)1.66100007
82Limb-girdle muscle weakness (HP:0003325)1.65457483
83Abnormality of the calcaneus (HP:0008364)1.63658669
84Elfin facies (HP:0004428)1.61832204
85Absent frontal sinuses (HP:0002688)1.61113410
86Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60374266
87Female pseudohermaphroditism (HP:0010458)1.57465831
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56859315
89Increased variability in muscle fiber diameter (HP:0003557)1.56700157
90Hypoplasia of the iris (HP:0007676)1.56660660
91Rhizomelia (HP:0008905)1.55712056
92Anomalous pulmonary venous return (HP:0010772)1.54586501
93Hyporeflexia of lower limbs (HP:0002600)1.52869558
94Inguinal hernia (HP:0000023)1.51945057
95Aortic aneurysm (HP:0004942)1.49594787
96Bronchitis (HP:0012387)1.49147433
97Tubulointerstitial nephritis (HP:0001970)1.48081570
98Tubular atrophy (HP:0000092)1.47688069
99Exercise-induced myalgia (HP:0003738)1.47201130
100Heterotopia (HP:0002282)1.46754570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.93815664
2PDK44.62181233
3PDK34.62181233
4CDK124.21848636
5PRKD33.96493868
6ICK3.88057430
7WNK33.00276754
8PDK22.62045098
9TRIB32.53776671
10PTK2B2.39883375
11TESK12.38951985
12RIPK12.29082814
13WNK42.24625725
14BRD41.92527002
15PTK61.83866651
16WNK11.83296013
17LATS11.80261289
18NEK21.77213649
19CDK71.71276180
20MAP3K41.60551646
21CDK91.59331913
22EEF2K1.47010458
23MAP3K101.45538033
24CDC71.44138853
25STK31.38759734
26PNCK1.38481758
27MYLK1.30614205
28PDGFRA1.24466942
29EPHB11.24131692
30PKN21.19095305
31CDK41.15988766
32STK391.14978302
33PAK41.14338658
34CAMK1G1.13999699
35MTOR1.10864515
36DAPK21.10181154
37PAK21.09090896
38TNK21.06290692
39LMTK20.95766731
40WEE10.85362430
41MAPK150.76817015
42CAMK1D0.73450503
43CSNK1A1L0.73431196
44DMPK0.68111505
45MAP2K20.66526086
46ATR0.64084481
47CHEK10.64083083
48FER0.61191634
49LATS20.58949291
50ERN10.58450718
51BMX0.58308603
52PASK0.58131929
53PTK20.57480870
54ATM0.55026125
55PDGFRB0.54257116
56CDC42BPA0.50293440
57TTN0.48823216
58PAK60.47814267
59STK380.45559576
60CHUK0.43330170
61STK38L0.40952905
62TTK0.39452392
63MET0.38801113
64FGFR10.38356049
65MAPK10.37755291
66RET0.36218543
67PRKACB0.36030650
68PRKD20.35828438
69PLK10.34397008
70CDK10.33790341
71PAK30.32968902
72GSK3B0.32803965
73CDK20.32108408
74MINK10.31807746
75LIMK10.31720751
76STK40.30840789
77NTRK20.30781969
78PRKDC0.29678566
79EGFR0.29155468
80KSR20.28372132
81MAPK30.27661603
82MKNK20.26671665
83ROCK10.25350237
84MAPK80.23936053
85CDK60.23653185
86RPS6KA20.23340939
87SCYL20.22611014
88MAPK140.22348674
89DYRK1B0.22164958
90DAPK10.21481240
91GSK3A0.21439095
92CSNK1G30.21316581
93CSNK1G20.20231879
94PDK10.19683267
95ERBB20.19235429
96ACVR1B0.18109510
97PAK10.17785950
98MAP2K40.15440985
99RPS6KA30.15243979
100CSK0.14292041

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.74437465
2Fatty acid biosynthesis_Homo sapiens_hsa000613.46002776
3ECM-receptor interaction_Homo sapiens_hsa045122.71851770
4Pyruvate metabolism_Homo sapiens_hsa006202.40075598
5Hedgehog signaling pathway_Homo sapiens_hsa043402.31199929
6Fatty acid metabolism_Homo sapiens_hsa012122.28527302
7Small cell lung cancer_Homo sapiens_hsa052222.25979225
8Vitamin digestion and absorption_Homo sapiens_hsa049772.19911865
9Amoebiasis_Homo sapiens_hsa051462.18119401
10mRNA surveillance pathway_Homo sapiens_hsa030152.11656881
11TGF-beta signaling pathway_Homo sapiens_hsa043502.10365790
12Ovarian steroidogenesis_Homo sapiens_hsa049132.01232437
13Lysine degradation_Homo sapiens_hsa003101.90188759
14Protein digestion and absorption_Homo sapiens_hsa049741.80824100
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75906896
16Renin secretion_Homo sapiens_hsa049241.61515966
17Oocyte meiosis_Homo sapiens_hsa041141.60420468
18Focal adhesion_Homo sapiens_hsa045101.55334497
19PPAR signaling pathway_Homo sapiens_hsa033201.47833936
20Notch signaling pathway_Homo sapiens_hsa043301.43846919
21RNA transport_Homo sapiens_hsa030131.41929302
22Toxoplasmosis_Homo sapiens_hsa051451.37858751
23Fatty acid elongation_Homo sapiens_hsa000621.37449409
24Mineral absorption_Homo sapiens_hsa049781.35596716
25Antigen processing and presentation_Homo sapiens_hsa046121.33482778
26Axon guidance_Homo sapiens_hsa043601.32785799
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31417162
28Basal transcription factors_Homo sapiens_hsa030221.30517935
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29351984
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28876656
31Basal cell carcinoma_Homo sapiens_hsa052171.24828837
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24784130
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21914728
34Glucagon signaling pathway_Homo sapiens_hsa049221.19860392
35Fatty acid degradation_Homo sapiens_hsa000711.17410088
36Selenocompound metabolism_Homo sapiens_hsa004501.17109775
37cAMP signaling pathway_Homo sapiens_hsa040241.16827495
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15319444
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.15141225
40Propanoate metabolism_Homo sapiens_hsa006401.10105960
41Estrogen signaling pathway_Homo sapiens_hsa049151.08832088
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05833195
43Hippo signaling pathway_Homo sapiens_hsa043901.04156617
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02773175
45Glycerolipid metabolism_Homo sapiens_hsa005611.00975102
46Tight junction_Homo sapiens_hsa045300.99056356
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98881235
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.97277065
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.97152238
50Complement and coagulation cascades_Homo sapiens_hsa046100.95518331
51Viral myocarditis_Homo sapiens_hsa054160.91202409
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90946708
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90618673
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89475938
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86129080
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85685472
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85200265
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.83032500
59Adherens junction_Homo sapiens_hsa045200.78834816
60VEGF signaling pathway_Homo sapiens_hsa043700.77818573
61Cell cycle_Homo sapiens_hsa041100.77421244
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.72086786
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71881137
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71466957
65Insulin resistance_Homo sapiens_hsa049310.71385035
66Linoleic acid metabolism_Homo sapiens_hsa005910.68097602
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67703144
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66770312
69Wnt signaling pathway_Homo sapiens_hsa043100.65921250
70Pathways in cancer_Homo sapiens_hsa052000.64401289
71Herpes simplex infection_Homo sapiens_hsa051680.64190700
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63116842
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.62664847
74HTLV-I infection_Homo sapiens_hsa051660.61543996
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58728768
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58119868
77Influenza A_Homo sapiens_hsa051640.58016371
78Gastric acid secretion_Homo sapiens_hsa049710.57951332
79Amphetamine addiction_Homo sapiens_hsa050310.57152561
80Proteoglycans in cancer_Homo sapiens_hsa052050.52682511
81Retinol metabolism_Homo sapiens_hsa008300.51722987
82Spliceosome_Homo sapiens_hsa030400.50378714
83Bile secretion_Homo sapiens_hsa049760.49107275
84Inositol phosphate metabolism_Homo sapiens_hsa005620.46644847
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.46251981
86Oxytocin signaling pathway_Homo sapiens_hsa049210.46115326
87N-Glycan biosynthesis_Homo sapiens_hsa005100.45953313
88Chemical carcinogenesis_Homo sapiens_hsa052040.45338996
89Prostate cancer_Homo sapiens_hsa052150.44316320
90Glutathione metabolism_Homo sapiens_hsa004800.43935239
91Fanconi anemia pathway_Homo sapiens_hsa034600.43139204
92Thyroid hormone synthesis_Homo sapiens_hsa049180.42800581
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42515044
94Endometrial cancer_Homo sapiens_hsa052130.41776955
95Fat digestion and absorption_Homo sapiens_hsa049750.41356739
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40309527
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.38086656
98AMPK signaling pathway_Homo sapiens_hsa041520.37495806
99Prolactin signaling pathway_Homo sapiens_hsa049170.37100156
100Cocaine addiction_Homo sapiens_hsa050300.36388129

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »