CSTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.45318371
2oligosaccharide catabolic process (GO:0009313)5.22916995
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06288757
4glycosphingolipid catabolic process (GO:0046479)5.03510355
5hydrogen peroxide biosynthetic process (GO:0050665)4.88196461
6keratinization (GO:0031424)4.85328620
7positive regulation by symbiont of host defense response (GO:0052509)4.79329389
8modulation by symbiont of host defense response (GO:0052031)4.79329389
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.79329389
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.79329389
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.79329389
12modulation by symbiont of host immune response (GO:0052553)4.79329389
13respiratory burst (GO:0045730)4.60570892
14superoxide anion generation (GO:0042554)4.59725337
15glycolipid catabolic process (GO:0019377)4.51253897
16response to peptidoglycan (GO:0032494)4.41826412
17amino sugar catabolic process (GO:0046348)4.40705512
18granulocyte activation (GO:0036230)4.40519238
19reactive oxygen species biosynthetic process (GO:1903409)4.30104523
20eosinophil chemotaxis (GO:0048245)4.22886081
21neutrophil activation (GO:0042119)4.13183560
22positive regulation of chemokine biosynthetic process (GO:0045080)4.08551784
23ceramide catabolic process (GO:0046514)4.02114482
24regulation of mononuclear cell migration (GO:0071675)3.93781876
25immunoglobulin mediated immune response (GO:0016064)3.86591356
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.84408685
27positive regulation of monocyte chemotaxis (GO:0090026)3.80236696
28cellular response to thyroid hormone stimulus (GO:0097067)3.79456277
29eosinophil migration (GO:0072677)3.78852818
30regulation of vitamin D biosynthetic process (GO:0060556)3.76471461
31barbed-end actin filament capping (GO:0051016)3.71023438
32lipoxygenase pathway (GO:0019372)3.66157138
33macrophage activation involved in immune response (GO:0002281)3.64343707
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.62387451
35positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.61611170
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.61460650
37positive regulation of interferon-alpha production (GO:0032727)3.57757532
38negative regulation of interleukin-12 production (GO:0032695)3.56821372
39monocyte chemotaxis (GO:0002548)3.52152222
40phagosome maturation (GO:0090382)3.51658641
41membrane lipid catabolic process (GO:0046466)3.44128083
42positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42132579
43regulation of chemokine biosynthetic process (GO:0045073)3.39582733
44regulation of interferon-alpha production (GO:0032647)3.39313390
45response to thyroid hormone (GO:0097066)3.38108851
46natural killer cell mediated cytotoxicity (GO:0042267)3.36300529
47natural killer cell mediated immunity (GO:0002228)3.36300529
48sphingolipid catabolic process (GO:0030149)3.36254651
49negative regulation of nitric oxide biosynthetic process (GO:0045019)3.33911425
50virion attachment to host cell (GO:0019062)3.33638830
51adhesion of symbiont to host cell (GO:0044650)3.33638830
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.32842783
53regulation of cholesterol storage (GO:0010885)3.32713108
54production of molecular mediator involved in inflammatory response (GO:0002532)3.31616612
55peptide cross-linking (GO:0018149)3.30398441
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.28811795
57positive regulation of mast cell degranulation (GO:0043306)3.28811795
58cellular response to arsenic-containing substance (GO:0071243)3.28758221
59myeloid cell activation involved in immune response (GO:0002275)3.28340335
60positive regulation of heat generation (GO:0031652)3.25243263
61negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.21259598
62regulation of membrane protein ectodomain proteolysis (GO:0051043)3.20231301
63positive regulation of antigen processing and presentation (GO:0002579)3.19867709
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18107151
65negative regulation of myeloid cell apoptotic process (GO:0033033)3.17954269
66regulation of fever generation (GO:0031620)3.16700070
67regulation of superoxide anion generation (GO:0032928)3.09690133
68regulation of interferon-beta biosynthetic process (GO:0045357)3.08029348
69positive regulation of mast cell activation (GO:0033005)3.07584966
70wound healing, spreading of epidermal cells (GO:0035313)3.06818481
71response to host immune response (GO:0052572)3.05862780
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05862780
73positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.04375596
74regulation of vitamin metabolic process (GO:0030656)3.03656884
75fat-soluble vitamin biosynthetic process (GO:0042362)3.03471510
76adhesion of symbiont to host (GO:0044406)3.02877164
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97935184
78regulation of mast cell degranulation (GO:0043304)2.97612205
79decidualization (GO:0046697)2.95870427
80regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95611834
81detection of molecule of bacterial origin (GO:0032490)2.95170816
82positive regulation of lymphocyte migration (GO:2000403)2.93513034
83myeloid cell homeostasis (GO:0002262)2.93355049
84microglial cell activation (GO:0001774)2.93160544
85regulation of antigen processing and presentation (GO:0002577)2.93012966
86regulation of monocyte chemotaxis (GO:0090025)2.92709562
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89497096
88regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.89094557
89macrophage activation (GO:0042116)2.88648102
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88583809
91cellular response to zinc ion (GO:0071294)2.88325063
92response to muramyl dipeptide (GO:0032495)2.87391742
93positive regulation of leukocyte degranulation (GO:0043302)2.86005216
94positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85733737
95regulation of T cell tolerance induction (GO:0002664)2.84121077
96regulation of podosome assembly (GO:0071801)2.83905683
97positive regulation of cellular amide metabolic process (GO:0034250)2.82763057
98lymphocyte chemotaxis (GO:0048247)2.81773734
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.81494762
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81059295
101keratinocyte differentiation (GO:0030216)2.79558515
102B cell mediated immunity (GO:0019724)2.78981793
103positive regulation of interleukin-6 production (GO:0032755)2.78914202
104regulation of mast cell activation involved in immune response (GO:0033006)2.78319636
105regulation of water loss via skin (GO:0033561)2.77060025
106cellular response to interferon-alpha (GO:0035457)2.76172182
107regulation of heterotypic cell-cell adhesion (GO:0034114)2.75639073
108positive regulation of NF-kappaB import into nucleus (GO:0042346)2.75477240
109regulation of macrophage chemotaxis (GO:0010758)2.75317684
110regulation of mast cell activation (GO:0033003)2.75213417
111N-acetylneuraminate metabolic process (GO:0006054)2.74737505
112positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74459153
113positive regulation of interferon-beta production (GO:0032728)2.73897196
114low-density lipoprotein particle clearance (GO:0034383)2.72733207
115negative regulation of mast cell activation (GO:0033004)2.72564549
116transferrin transport (GO:0033572)2.72211154
117regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.71657720
118leukocyte mediated cytotoxicity (GO:0001909)2.70073282
119aldehyde catabolic process (GO:0046185)2.69937157
120positive regulation of chemokine production (GO:0032722)2.69449539
121leukocyte aggregation (GO:0070486)2.67745726
122regulation of T-helper 1 cell differentiation (GO:0045625)2.67185053
123positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.65445548
124negative regulation of interleukin-17 production (GO:0032700)2.64751870
125cellular response to cadmium ion (GO:0071276)2.63605605
126T-helper 1 type immune response (GO:0042088)2.63355852
127regulation of lymphocyte chemotaxis (GO:1901623)2.62888258
128cellular response to interferon-beta (GO:0035458)2.61896948
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61394403
130myeloid dendritic cell activation (GO:0001773)2.60847169
131regulation of cytokine secretion involved in immune response (GO:0002739)2.60751483
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.60560956
133superoxide metabolic process (GO:0006801)2.60373283
134defense response to protozoan (GO:0042832)2.59725534
135response to interferon-beta (GO:0035456)2.59647059
136detection of other organism (GO:0098543)2.59469863
137positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59326807
138regulation of tolerance induction (GO:0002643)2.58793668
139NIK/NF-kappaB signaling (GO:0038061)2.58758047
140positive regulation of acute inflammatory response (GO:0002675)2.58698431
141macrophage chemotaxis (GO:0048246)2.58531633
142myeloid dendritic cell differentiation (GO:0043011)2.58105736
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57898534
144establishment of skin barrier (GO:0061436)2.57835664
145protein neddylation (GO:0045116)2.57664345
146regulation of hypersensitivity (GO:0002883)2.57113991
147pinocytosis (GO:0006907)2.56884258
148regulation of heat generation (GO:0031650)2.55607764
149dendritic cell differentiation (GO:0097028)2.54789894
150positive regulation of tolerance induction (GO:0002645)2.51860987
151ribosomal small subunit biogenesis (GO:0042274)2.51263855
152protein localization to endosome (GO:0036010)2.51119727
153ferric iron transport (GO:0015682)2.49422498
154trivalent inorganic cation transport (GO:0072512)2.49422498
155desmosome organization (GO:0002934)2.49272779
156regulation of monocyte differentiation (GO:0045655)2.49130228
157branching involved in labyrinthine layer morphogenesis (GO:0060670)2.47893207
158apoptotic cell clearance (GO:0043277)2.47752085
159regulation of inflammatory response to antigenic stimulus (GO:0002861)2.46884763
160response to progesterone (GO:0032570)2.46524767
161interferon-gamma-mediated signaling pathway (GO:0060333)2.45531643
162keratan sulfate catabolic process (GO:0042340)2.45511308
163macrophage differentiation (GO:0030225)2.44710440
164amyloid precursor protein catabolic process (GO:0042987)2.43320265
165negative regulation of lipid storage (GO:0010888)2.43057766
166glucosamine-containing compound catabolic process (GO:1901072)2.42244179
167energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41680465
168ATP hydrolysis coupled proton transport (GO:0015991)2.41680465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.43871233
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.31436420
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.66077711
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.95669654
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.03263432
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.69905834
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.59299373
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33676917
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31156655
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15535292
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09712234
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64204257
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.58879748
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49311614
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49008968
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41187132
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37805664
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34681859
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22300402
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19524367
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16871844
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03712669
23LXR_22292898_ChIP-Seq_THP-1_Human2.03658114
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01450326
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93913262
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.91897136
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90380248
28SPI1_23547873_ChIP-Seq_NB4_Human1.90274755
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.89327871
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87176858
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.79558765
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76400265
33VDR_21846776_ChIP-Seq_THP-1_Human1.75633918
34RACK7_27058665_Chip-Seq_MCF-7_Human1.71060237
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63037138
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.60642813
37ZNF263_19887448_ChIP-Seq_K562_Human1.59651952
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58909082
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58144702
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53436107
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53119148
42* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45687354
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45576955
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44502483
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41883362
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41718979
47* SOX2_20726797_ChIP-Seq_SW620_Human1.39777260
48ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37022916
49ELK1_19687146_ChIP-ChIP_HELA_Human1.36493619
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36025189
51* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35958359
52* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35958359
53STAT1_20625510_ChIP-Seq_HELA_Human1.35288967
54* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32569631
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.30457135
56* PU_27001747_Chip-Seq_BMDM_Mouse1.30015296
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.27761869
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27445400
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27445400
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27015215
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.26615610
62ATF3_27146783_Chip-Seq_COLON_Human1.26085974
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25698502
64* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25293591
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25145511
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25066023
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23175823
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22738593
69VDR_24787735_ChIP-Seq_THP-1_Human1.22215995
70* BCL6_27268052_Chip-Seq_Bcells_Human1.22151944
71* BCOR_27268052_Chip-Seq_Bcells_Human1.21132470
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19555200
73CLOCK_20551151_ChIP-Seq_293T_Human1.17460598
74* TFEB_21752829_ChIP-Seq_HELA_Human1.16231576
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15508862
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14646263
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14597518
78SPI1_23127762_ChIP-Seq_K562_Human1.13278888
79* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13182713
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13126719
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13030401
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12621214
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12492190
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10436682
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10174866
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09777050
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09722690
88* ELF1_20517297_ChIP-Seq_JURKAT_Human1.07160788
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.07051228
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07008000
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06840031
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06591144
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06478206
94* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05289267
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.03918042
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03539752
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02423441
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02214502
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01276800
100VDR_24763502_ChIP-Seq_THP-1_Human1.00938801
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00819743
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00646780
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00533825
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00369890
105RUNX1_22412390_ChIP-Seq_EML_Mouse0.99952697
106* SA1_27219007_Chip-Seq_Bcells_Human0.99282911
107* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99238480
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98459645
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.98295832
110GATA3_26560356_Chip-Seq_TH2_Human0.97717021
111* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97303650
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96904012
113* P68_20966046_ChIP-Seq_HELA_Human0.96091923
114TET1_21451524_ChIP-Seq_MESCs_Mouse0.95736533
115CJUN_26792858_Chip-Seq_BT549_Human0.95381555
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94306763
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94035448
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93563468
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.93422915
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93190944
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91654552
122* MYB_26560356_Chip-Seq_TH2_Human0.90050216
123* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88978519
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86289984
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83470902
126EGR1_19032775_ChIP-ChIP_M12_Human0.83383615
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82968478
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81388726
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81388726
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81388726
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79669591
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79241666
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.78601878
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75150873
135GATA4_25053715_ChIP-Seq_YYC3_Human0.74781226
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73553512
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73480997
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73467576
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73408878
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72632808
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70977899
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70772674
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70616535
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70287888
145JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69150443
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69105996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93530579
2MP0003436_decreased_susceptibility_to3.83325310
3MP0002148_abnormal_hypersensitivity_rea3.79897237
4MP0009785_altered_susceptibility_to3.58957171
5MP0006082_CNS_inflammation3.57167430
6MP0002139_abnormal_hepatobiliary_system3.39832301
7MP0005058_abnormal_lysosome_morphology3.32748032
8MP0003724_increased_susceptibility_to3.06665978
9MP0002419_abnormal_innate_immunity3.04779536
10MP0003806_abnormal_nucleotide_metabolis3.04211892
11MP0005000_abnormal_immune_tolerance2.98727413
12MP0010234_abnormal_vibrissa_follicle2.92152483
13MP0005025_abnormal_response_to2.75516398
14MP0003303_peritoneal_inflammation2.43490193
15MP0003186_abnormal_redox_activity2.27974791
16MP0002452_abnormal_antigen_presenting2.27077826
17MP0001790_abnormal_immune_system2.22852970
18MP0005387_immune_system_phenotype2.22852970
19MP0001533_abnormal_skeleton_physiology2.19575933
20MP0002723_abnormal_immune_serum2.11072287
21MP0005671_abnormal_response_to2.10959463
22MP0004947_skin_inflammation2.09309701
23MP0003195_calcinosis2.08412164
24MP0000685_abnormal_immune_system2.03436274
25MP0009764_decreased_sensitivity_to1.93233358
26MP0003448_altered_tumor_morphology1.90330702
27MP0002877_abnormal_melanocyte_morpholog1.84969609
28MP0002254_reproductive_system_inflammat1.83744794
29MP0001800_abnormal_humoral_immune1.82991092
30MP0001819_abnormal_immune_cell1.82731090
31MP0001853_heart_inflammation1.82112915
32MP0002420_abnormal_adaptive_immunity1.79552484
33MP0000343_altered_response_to1.78781892
34MP0002405_respiratory_system_inflammati1.77486193
35MP0001845_abnormal_inflammatory_respons1.73835364
36MP0004510_myositis1.73309076
37MP0003453_abnormal_keratinocyte_physiol1.70312079
38MP0009840_abnormal_foam_cell1.69870607
39MP0002998_abnormal_bone_remodeling1.65335280
40MP0005464_abnormal_platelet_physiology1.64162089
41MP0009333_abnormal_splenocyte_physiolog1.58767428
42MP0002277_abnormal_respiratory_mucosa1.57646321
43MP0004782_abnormal_surfactant_physiolog1.52076434
44MP0008469_abnormal_protein_level1.50509885
45MP0000858_altered_metastatic_potential1.49005627
46MP0005365_abnormal_bile_salt1.48183056
47MP0005310_abnormal_salivary_gland1.48086485
48MP0005451_abnormal_body_composition1.41385081
49MP0004381_abnormal_hair_follicle1.41322536
50MP0010386_abnormal_urinary_bladder1.38865541
51MP0008260_abnormal_autophagy1.38773685
52MP0005164_abnormal_response_to1.38037307
53MP0003075_altered_response_to1.37272129
54MP0003136_yellow_coat_color1.37088268
55MP0002006_tumorigenesis1.35257291
56MP0010155_abnormal_intestine_physiology1.33189346
57MP0003300_gastrointestinal_ulcer1.30933715
58MP0003172_abnormal_lysosome_physiology1.30837915
59MP0003941_abnormal_skin_development1.29324560
60MP0002796_impaired_skin_barrier1.29272862
61MP0005390_skeleton_phenotype1.28828756
62MP0001542_abnormal_bone_strength1.25610089
63MP0003191_abnormal_cellular_cholesterol1.25288142
64MP0008438_abnormal_cutaneous_collagen1.19660974
65MP0000604_amyloidosis1.18511697
66MP0004043_abnormal_pH_regulation1.17883277
67MP0003690_abnormal_glial_cell1.17529174
68MP0005257_abnormal_intraocular_pressure1.14595909
69MP0005166_decreased_susceptibility_to1.13878052
70MP0000716_abnormal_immune_system1.12565137
71MP0000920_abnormal_myelination1.11767978
72MP0000371_diluted_coat_color1.07239781
73MP0002295_abnormal_pulmonary_circulatio1.03489645
74MP0002933_joint_inflammation1.03030647
75MP0002098_abnormal_vibrissa_morphology1.02288645
76MP0001216_abnormal_epidermal_layer1.02187117
77MP0000372_irregular_coat_pigmentation1.02043479
78MP0005165_increased_susceptibility_to1.00694836
79MP0003329_amyloid_beta_deposits1.00499515
80MP0003566_abnormal_cell_adhesion0.99878442
81MP0005167_abnormal_blood-brain_barrier0.99805592
82MP0008875_abnormal_xenobiotic_pharmacok0.95253748
83MP0003011_delayed_dark_adaptation0.94972277
84MP0003950_abnormal_plasma_membrane0.93264601
85MP0005275_abnormal_skin_tensile0.91689735
86MP0005408_hypopigmentation0.91173874
87MP0003828_pulmonary_edema0.90537325
88MP0000678_abnormal_parathyroid_gland0.88735619
89MP0000647_abnormal_sebaceous_gland0.85688851
90MP0002429_abnormal_blood_cell0.84880858
91MP0003795_abnormal_bone_structure0.84397845
92MP0003656_abnormal_erythrocyte_physiolo0.83767686
93MP0001346_abnormal_lacrimal_gland0.82500822
94MP0000383_abnormal_hair_follicle0.81529313
95MP0002060_abnormal_skin_morphology0.81224410
96MP0009379_abnormal_foot_pigmentation0.80061487
97MP0002398_abnormal_bone_marrow0.79803174
98MP0009278_abnormal_bone_marrow0.78212075
99MP0002136_abnormal_kidney_physiology0.77933074
100MP0005023_abnormal_wound_healing0.77283594
101MP0010678_abnormal_skin_adnexa0.76922534
102MP0005171_absent_coat_pigmentation0.76102150
103MP0009763_increased_sensitivity_to0.75319123
104MP0005397_hematopoietic_system_phenotyp0.75216143
105MP0001545_abnormal_hematopoietic_system0.75216143
106MP0000689_abnormal_spleen_morphology0.74612372
107MP0000627_abnormal_mammary_gland0.73732515
108MP0009643_abnormal_urine_homeostasis0.72926394
109MP0002138_abnormal_hepatobiliary_system0.72558005
110MP0005319_abnormal_enzyme/_coenzyme0.72433375
111MP0005647_abnormal_sex_gland0.72374004
112MP0001243_abnormal_dermal_layer0.71821830
113MP0004185_abnormal_adipocyte_glucose0.71809909
114MP0002722_abnormal_immune_system0.71407884
115MP0001958_emphysema0.71265783
116MP0009765_abnormal_xenobiotic_induced0.70978981
117* MP0001851_eye_inflammation0.70168897
118MP0000681_abnormal_thyroid_gland0.69249322
119MP0003718_maternal_effect0.69018392
120MP0003705_abnormal_hypodermis_morpholog0.67996978
121MP0002837_dystrophic_cardiac_calcinosis0.67912285
122MP0006054_spinal_hemorrhage0.64960295
123MP0008004_abnormal_stomach_pH0.64637482
124MP0010771_integument_phenotype0.64497698
125MP0001663_abnormal_digestive_system0.64241169
126MP0005501_abnormal_skin_physiology0.63760165
127MP0004019_abnormal_vitamin_homeostasis0.63308342
128MP0002090_abnormal_vision0.62712353

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.78627147
2Recurrent abscess formation (HP:0002722)6.61179669
3Recurrent bacterial skin infections (HP:0005406)6.09253257
4Abnormality of macrophages (HP:0004311)5.56406989
5Recurrent gram-negative bacterial infections (HP:0005420)5.55460140
6Vacuolated lymphocytes (HP:0001922)5.06771272
7Parakeratosis (HP:0001036)4.34927925
8Increased cerebral lipofuscin (HP:0011813)4.25129827
9Mediastinal lymphadenopathy (HP:0100721)4.23843182
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.21371903
11Axonal loss (HP:0003447)4.08821158
12Obstructive lung disease (HP:0006536)3.90726282
13Chronic obstructive pulmonary disease (HP:0006510)3.90726282
14Oral leukoplakia (HP:0002745)3.90534137
15Abnormality of glycolipid metabolism (HP:0010969)3.83294316
16Abnormality of liposaccharide metabolism (HP:0010968)3.83294316
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.83294316
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.77159615
19Stomatitis (HP:0010280)3.73935692
20Recurrent skin infections (HP:0001581)3.62751735
21Gingivitis (HP:0000230)3.54323442
22Autoimmune thrombocytopenia (HP:0001973)3.37028969
23Elevated erythrocyte sedimentation rate (HP:0003565)3.35490008
24Nuclear cataract (HP:0100018)3.30918390
25Mutism (HP:0002300)3.27200908
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18325814
27Hepatosplenomegaly (HP:0001433)3.13392180
28Prostate neoplasm (HP:0100787)3.12622506
29Congenital ichthyosiform erythroderma (HP:0007431)3.08676211
30Systemic lupus erythematosus (HP:0002725)3.07701820
31Thick nail (HP:0001805)3.07201649
32Neurofibrillary tangles (HP:0002185)3.06611812
33Interstitial pulmonary disease (HP:0006530)3.05325339
34Orchitis (HP:0100796)3.00859769
35Poor head control (HP:0002421)2.98932402
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91867136
37Pustule (HP:0200039)2.90425275
38Disinhibition (HP:0000734)2.88446858
39Basal ganglia calcification (HP:0002135)2.87137225
40Recurrent fungal infections (HP:0002841)2.84249997
41Myositis (HP:0100614)2.83966983
42Dysostosis multiplex (HP:0000943)2.83459515
43Urticaria (HP:0001025)2.77590875
44Retrobulbar optic neuritis (HP:0100654)2.77055934
45Optic neuritis (HP:0100653)2.77055934
46Increased IgE level (HP:0003212)2.76915445
47Increased IgM level (HP:0003496)2.76880198
48Prolonged neonatal jaundice (HP:0006579)2.67733211
49Abnormality of the nasal mucosa (HP:0000433)2.62800506
50Metaphyseal irregularity (HP:0003025)2.62054964
51Nausea (HP:0002018)2.59873655
52Diminished motivation (HP:0000745)2.56051611
53Progressive neurologic deterioration (HP:0002344)2.55492663
54Vertebral compression fractures (HP:0002953)2.54677508
55Apathy (HP:0000741)2.53560766
56Vasculitis (HP:0002633)2.52338350
57Abnormality of nail color (HP:0100643)2.51789668
58Recurrent pneumonia (HP:0006532)2.50039610
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.45199727
60Osteolytic defects of the hand bones (HP:0009699)2.45199727
61Segmental peripheral demyelination/remyelination (HP:0003481)2.37561129
62Cellulitis (HP:0100658)2.36069487
63Tetraparesis (HP:0002273)2.33461820
64Petechiae (HP:0000967)2.31972420
65Nasal polyposis (HP:0100582)2.29896326
66Malnutrition (HP:0004395)2.21631474
67Hypergammaglobulinemia (HP:0010702)2.20834360
68Alopecia of scalp (HP:0002293)2.20582027
69Anhidrosis (HP:0000970)2.19573222
70Purpura (HP:0000979)2.19412475
71Premature loss of primary teeth (HP:0006323)2.15566936
72Osteomyelitis (HP:0002754)2.13704730
73Periodontitis (HP:0000704)2.13557268
74Agnosia (HP:0010524)2.11464057
75Cerebral inclusion bodies (HP:0100314)2.11187142
76Myocardial infarction (HP:0001658)2.09807994
77Neuronal loss in central nervous system (HP:0002529)2.06715478
78Upper motor neuron abnormality (HP:0002127)2.05743770
79Bone pain (HP:0002653)2.04895494
80Recurrent lower respiratory tract infections (HP:0002783)2.03142471
81Dementia (HP:0000726)2.03092671
82Sparse eyelashes (HP:0000653)2.02880913
83Cheilitis (HP:0100825)2.02047592
84Erythroderma (HP:0001019)2.01093939
85Mucopolysacchariduria (HP:0008155)2.00335516
86Urinary glycosaminoglycan excretion (HP:0003541)2.00335516
87Cardiomegaly (HP:0001640)2.00151801
88Glomerulonephritis (HP:0000099)2.00052567
89Complement deficiency (HP:0004431)1.99846911
90Pulmonary infiltrates (HP:0002113)1.99042386
91Amyloidosis (HP:0011034)1.97446050
92Leukocytosis (HP:0001974)1.96068877
93Chronic mucocutaneous candidiasis (HP:0002728)1.93962201
94Recurrent cutaneous fungal infections (HP:0011370)1.93962201
95Distal lower limb muscle weakness (HP:0009053)1.91120943
96Abnormal trabecular bone morphology (HP:0100671)1.91090002
97Multiple enchondromatosis (HP:0005701)1.89118217
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89043333
99Loss of speech (HP:0002371)1.88049405
100Abnormality of iron homeostasis (HP:0011031)1.87483163
101Progressive visual loss (HP:0000529)1.85952455
102Pathologic fracture (HP:0002756)1.85665196
103Exertional dyspnea (HP:0002875)1.84847147
104Fused cervical vertebrae (HP:0002949)1.84479170
105Abnormal hemoglobin (HP:0011902)1.84360160
106Erythema (HP:0010783)1.83759614
107J-shaped sella turcica (HP:0002680)1.83007629
108Paralysis (HP:0003470)1.82043100
109Xanthomatosis (HP:0000991)1.79940013
110Palmoplantar hyperkeratosis (HP:0000972)1.79240958
111Retinal atrophy (HP:0001105)1.79006090
112Recurrent viral infections (HP:0004429)1.78555028
113Peripheral demyelination (HP:0011096)1.78484421
114Abnormality of polysaccharide metabolism (HP:0011012)1.78097445
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78097445
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78097445
117Rough bone trabeculation (HP:0100670)1.77310803
118Generalized aminoaciduria (HP:0002909)1.76476110
119Anorexia (HP:0002039)1.76398370
120Personality changes (HP:0000751)1.73518139
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73337343
122Supranuclear gaze palsy (HP:0000605)1.72384658
123Abnormality of complement system (HP:0005339)1.72088144
124Nail dystrophy (HP:0008404)1.72086050
125Increased serum ferritin (HP:0003281)1.71915573
126Renal Fanconi syndrome (HP:0001994)1.71459126
127Skin ulcer (HP:0200042)1.71403032
128Corneal erosion (HP:0200020)1.71267761
129Eosinophilia (HP:0001880)1.70668144
130Polygenic inheritance (HP:0010982)1.69900997
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69227059
132Sepsis (HP:0100806)1.68717901
133Gangrene (HP:0100758)1.68609937
134Protuberant abdomen (HP:0001538)1.68535076
135Meningitis (HP:0001287)1.68459562
136Abnormality of the pericardium (HP:0001697)1.68022000
137Hypokinesia (HP:0002375)1.67981818
138Autoimmune hemolytic anemia (HP:0001890)1.66783085
139Palmar hyperkeratosis (HP:0010765)1.66298865
140Hyperparathyroidism (HP:0000843)1.66078026
141Plantar hyperkeratosis (HP:0007556)1.65839560
142Juvenile onset (HP:0003621)1.65653953
143Inappropriate behavior (HP:0000719)1.61938020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.54214967
2RIPK43.61778252
3MAP3K143.59703984
4BLK3.39991176
5NME23.19458119
6MST43.10405193
7PIM23.04421114
8IRAK33.04006785
9TBK12.78490656
10MST1R2.54413252
11TAOK22.45735161
12IRAK42.43941935
13IKBKB2.25595251
14DDR22.25418210
15TAOK12.04306585
16ABL22.02982405
17EPHA21.97741573
18RIPK11.89024199
19IKBKE1.83109228
20TYK21.75286960
21TGFBR21.67454080
22ARAF1.64540546
23NEK91.54003560
24TXK1.52359113
25ERN11.50454700
26TRPM71.48195626
27TESK11.43821021
28EIF2AK31.35826655
29CDC42BPA1.35732240
30MAPKAPK31.29644379
31BMPR21.28600641
32JAK31.25828613
33MET1.24087566
34KIT1.23902538
35MAP3K31.20223445
36BMX1.19551907
37BCR1.17266732
38EPHB11.11299519
39PAK41.10714199
40BMPR1B1.09720502
41MAP2K31.07784647
42ERBB31.05949571
43LIMK11.05802819
44EIF2AK21.01321717
45MAP2K60.99311642
46FGR0.98819247
47CSK0.98507166
48PRPF4B0.98045231
49RPS6KA40.97652215
50MAP3K110.96304994
51STK160.95819794
52CHUK0.95331803
53MAPK150.94262519
54LYN0.93906844
55SIK10.93670181
56PIM10.90971521
57STK40.88981568
58MAP4K10.88891640
59TESK20.84714974
60JAK10.82105007
61GRK70.79885359
62EIF2AK10.79564843
63LRRK20.78998987
64ERBB40.78471269
65ZAP700.78089337
66PRKCD0.77874689
67BCKDK0.74242569
68ABL10.73976205
69STK100.73891623
70STK240.73782213
71SYK0.72850961
72YES10.72834624
73IRAK10.72825383
74TEC0.72728388
75LCK0.71551617
76WNK40.70385721
77HCK0.69624426
78MAP3K90.68850416
79STK390.67082815
80CAMK1D0.66689662
81MOS0.66546610
82MARK30.65888626
83MAP2K20.63820576
84PTK20.63515182
85TGFBR10.62642617
86BTK0.61990044
87PLK40.61786706
88TRIB30.61285604
89ZAK0.60071199
90DMPK0.59147724
91MATK0.58954502
92IRAK20.58941831
93EPHB20.57872431
94MAP3K130.56152683
95MAP3K120.54894266
96PDPK10.53647241
97RPS6KA50.52873404
98PRKG20.52308038
99EPHA30.51277854
100KDR0.50234368
101ADRBK20.49704768
102PIK3CG0.49484207
103MAP3K80.49436099
104EGFR0.49121852
105STK30.49101310
106MAPKAPK20.45675924
107BUB10.45054597
108ILK0.44622490
109JAK20.44263783
110CLK10.43717172
111VRK20.42975934
112DAPK30.42485833
113MAPKAPK50.41850104
114NEK60.40723232
115PRKCE0.37734490
116RPS6KL10.37075527
117RPS6KC10.37075527
118MAP3K50.36969586
119MAP3K20.36465088
120GSK3A0.36401386
121TLK10.36321542
122PDK20.35498523
123CSF1R0.35472213
124OXSR10.33768864
125RPS6KA20.32186041
126ACVR1B0.31919209
127MAP3K60.31807437
128PRKD20.31743239
129CAMKK20.31522176
130PAK10.31211627
131TYRO30.30834618
132LATS20.29219252
133CAMK2G0.28151920
134NME10.27029128
135ICK0.26644836
136MAP3K10.26404219
137ITK0.26322680
138BRAF0.26208147
139PRKCQ0.25932584
140RPS6KA60.25123980
141NUAK10.23805689

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.17126913
2Rheumatoid arthritis_Homo sapiens_hsa053232.98857463
3Proteasome_Homo sapiens_hsa030502.89882690
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83328982
5Leishmaniasis_Homo sapiens_hsa051402.70590945
6Lysosome_Homo sapiens_hsa041422.54767768
7Legionellosis_Homo sapiens_hsa051342.49501073
8Malaria_Homo sapiens_hsa051442.32122755
9Phagosome_Homo sapiens_hsa041452.27937663
10Asthma_Homo sapiens_hsa053102.24165488
11Staphylococcus aureus infection_Homo sapiens_hsa051502.22510466
12Allograft rejection_Homo sapiens_hsa053302.19744257
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19023444
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16771637
15Collecting duct acid secretion_Homo sapiens_hsa049662.10588928
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.07209268
17Pertussis_Homo sapiens_hsa051332.06504875
18Tuberculosis_Homo sapiens_hsa051521.93461891
19Salmonella infection_Homo sapiens_hsa051321.78614214
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75585512
21Osteoclast differentiation_Homo sapiens_hsa043801.72625407
22Oxidative phosphorylation_Homo sapiens_hsa001901.65085161
23Ribosome_Homo sapiens_hsa030101.60713716
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55407197
25Steroid biosynthesis_Homo sapiens_hsa001001.54509692
26TNF signaling pathway_Homo sapiens_hsa046681.49891691
27Other glycan degradation_Homo sapiens_hsa005111.49118178
28Type I diabetes mellitus_Homo sapiens_hsa049401.48783907
29Sphingolipid metabolism_Homo sapiens_hsa006001.48197107
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47894170
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47645374
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47195470
33Sulfur metabolism_Homo sapiens_hsa009201.45504302
34Hematopoietic cell lineage_Homo sapiens_hsa046401.36747187
35Galactose metabolism_Homo sapiens_hsa000521.32709924
36Measles_Homo sapiens_hsa051621.31410647
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.29204957
38Vibrio cholerae infection_Homo sapiens_hsa051101.27325847
39Protein export_Homo sapiens_hsa030601.27091558
40Shigellosis_Homo sapiens_hsa051311.22555162
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18735148
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18410690
43Apoptosis_Homo sapiens_hsa042101.17853235
44Autoimmune thyroid disease_Homo sapiens_hsa053201.17637093
45Antigen processing and presentation_Homo sapiens_hsa046121.15895969
46Influenza A_Homo sapiens_hsa051641.15049054
47African trypanosomiasis_Homo sapiens_hsa051431.12719571
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.11757112
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11589620
50Bladder cancer_Homo sapiens_hsa052191.07965855
51Mineral absorption_Homo sapiens_hsa049781.06596246
52Fructose and mannose metabolism_Homo sapiens_hsa000511.05073910
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99549991
54Toxoplasmosis_Homo sapiens_hsa051450.98196807
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.92886152
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92163983
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89160309
58Herpes simplex infection_Homo sapiens_hsa051680.88719698
59Arachidonic acid metabolism_Homo sapiens_hsa005900.86301894
60RNA polymerase_Homo sapiens_hsa030200.84491831
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84469890
62Chemokine signaling pathway_Homo sapiens_hsa040620.83259676
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.81155683
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.80824767
65Parkinsons disease_Homo sapiens_hsa050120.79657936
66Ether lipid metabolism_Homo sapiens_hsa005650.78281600
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76892463
68Hepatitis C_Homo sapiens_hsa051600.76581478
69PPAR signaling pathway_Homo sapiens_hsa033200.76448475
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73609508
71Folate biosynthesis_Homo sapiens_hsa007900.73045844
72Glutathione metabolism_Homo sapiens_hsa004800.72527627
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72017702
74Amoebiasis_Homo sapiens_hsa051460.71352560
75Epstein-Barr virus infection_Homo sapiens_hsa051690.69018904
76Synaptic vesicle cycle_Homo sapiens_hsa047210.68671124
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68665870
78Regulation of autophagy_Homo sapiens_hsa041400.68554953
79Alzheimers disease_Homo sapiens_hsa050100.68480391
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64353099
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.62913628
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61703879
83B cell receptor signaling pathway_Homo sapiens_hsa046620.60199088
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58793398
85Histidine metabolism_Homo sapiens_hsa003400.56546876
86Huntingtons disease_Homo sapiens_hsa050160.55176422
87Hepatitis B_Homo sapiens_hsa051610.52657263
88Prion diseases_Homo sapiens_hsa050200.51767553
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50014887
90Phenylalanine metabolism_Homo sapiens_hsa003600.48945409
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47209883
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.46667323
93Linoleic acid metabolism_Homo sapiens_hsa005910.45490802
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42656515
95Tyrosine metabolism_Homo sapiens_hsa003500.41279815
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39711677
97Complement and coagulation cascades_Homo sapiens_hsa046100.38308049
98Endocytosis_Homo sapiens_hsa041440.37126374
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36347115
100Viral myocarditis_Homo sapiens_hsa054160.36148072
101Primary immunodeficiency_Homo sapiens_hsa053400.34954269
102Sulfur relay system_Homo sapiens_hsa041220.34715172
103Acute myeloid leukemia_Homo sapiens_hsa052210.34353894
104p53 signaling pathway_Homo sapiens_hsa041150.34116960
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33752169
106Notch signaling pathway_Homo sapiens_hsa043300.32553268
107Renin-angiotensin system_Homo sapiens_hsa046140.32046012
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29375788
109VEGF signaling pathway_Homo sapiens_hsa043700.29005815
110T cell receptor signaling pathway_Homo sapiens_hsa046600.27178660
111Pyrimidine metabolism_Homo sapiens_hsa002400.26433466
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24875191
113Pentose phosphate pathway_Homo sapiens_hsa000300.24731833
114Chemical carcinogenesis_Homo sapiens_hsa052040.23140068
115Caffeine metabolism_Homo sapiens_hsa002320.22130659
116Fatty acid elongation_Homo sapiens_hsa000620.20897191
117Proteoglycans in cancer_Homo sapiens_hsa052050.20651000
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20093874
119HIF-1 signaling pathway_Homo sapiens_hsa040660.19303051

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