CSTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.85310221
2DNA double-strand break processing (GO:0000729)4.64663947
3protein localization to kinetochore (GO:0034501)4.52008661
4DNA strand elongation involved in DNA replication (GO:0006271)4.51253135
5maturation of SSU-rRNA (GO:0030490)4.35297106
6DNA replication initiation (GO:0006270)4.35019871
7DNA strand elongation (GO:0022616)4.34174448
8mitotic metaphase plate congression (GO:0007080)4.28363696
9ribosomal small subunit assembly (GO:0000028)4.27470342
10telomere maintenance via semi-conservative replication (GO:0032201)4.26629109
11nucleobase biosynthetic process (GO:0046112)4.22253838
12protein localization to chromosome, centromeric region (GO:0071459)4.05461934
13DNA unwinding involved in DNA replication (GO:0006268)4.04793299
14DNA replication checkpoint (GO:0000076)4.02770556
15mitotic nuclear envelope disassembly (GO:0007077)4.02180576
16purine nucleobase biosynthetic process (GO:0009113)4.02121108
17negative regulation of DNA-dependent DNA replication (GO:2000104)3.98301602
18formation of translation preinitiation complex (GO:0001731)3.87585022
19synapsis (GO:0007129)3.84865304
20replication fork processing (GO:0031297)3.83500560
21protein K6-linked ubiquitination (GO:0085020)3.82619402
22ribosome biogenesis (GO:0042254)3.82311810
23telomere maintenance via recombination (GO:0000722)3.80786247
24DNA replication-dependent nucleosome organization (GO:0034723)3.76294871
25DNA replication-dependent nucleosome assembly (GO:0006335)3.76294871
26metaphase plate congression (GO:0051310)3.70860616
27membrane disassembly (GO:0030397)3.68287730
28nuclear envelope disassembly (GO:0051081)3.68287730
29IMP biosynthetic process (GO:0006188)3.65862779
30cullin deneddylation (GO:0010388)3.62320092
31CENP-A containing nucleosome assembly (GO:0034080)3.59741265
32chromatin remodeling at centromere (GO:0031055)3.59118744
33mitotic recombination (GO:0006312)3.58871157
34mitotic sister chromatid segregation (GO:0000070)3.58801730
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.57194799
36ribonucleoprotein complex biogenesis (GO:0022613)3.56245553
37viral transcription (GO:0019083)3.54858218
38telomere maintenance via telomere lengthening (GO:0010833)3.54170034
39translational termination (GO:0006415)3.52364287
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50432151
41folic acid-containing compound biosynthetic process (GO:0009396)3.49492509
42ribosome assembly (GO:0042255)3.49259701
43ribosomal large subunit biogenesis (GO:0042273)3.48528106
44protein deneddylation (GO:0000338)3.47956633
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47031185
46water-soluble vitamin biosynthetic process (GO:0042364)3.46308474
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44529483
48attachment of spindle microtubules to kinetochore (GO:0008608)3.44027488
49regulation of DNA endoreduplication (GO:0032875)3.42699059
50regulation of spindle organization (GO:0090224)3.41884455
51DNA catabolic process, exonucleolytic (GO:0000738)3.39296261
52DNA replication-independent nucleosome assembly (GO:0006336)3.39282319
53DNA replication-independent nucleosome organization (GO:0034724)3.39282319
54spliceosomal snRNP assembly (GO:0000387)3.36175914
55mitotic chromosome condensation (GO:0007076)3.35218740
56nuclear pore organization (GO:0006999)3.34781623
57DNA ligation (GO:0006266)3.33565339
58IMP metabolic process (GO:0046040)3.33307363
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.33294282
60translational elongation (GO:0006414)3.31716139
61establishment of chromosome localization (GO:0051303)3.31453244
62translational initiation (GO:0006413)3.30336069
63viral mRNA export from host cell nucleus (GO:0046784)3.29594189
64rRNA processing (GO:0006364)3.27932644
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26799005
66regulation of mitotic spindle checkpoint (GO:1903504)3.26799005
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25821907
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.23342409
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.23342409
70isotype switching (GO:0045190)3.23342409
71regulation of meiosis I (GO:0060631)3.22881585
72resolution of meiotic recombination intermediates (GO:0000712)3.21778976
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.21435910
74sister chromatid segregation (GO:0000819)3.18079737
75histone exchange (GO:0043486)3.17484487
76ribosomal small subunit biogenesis (GO:0042274)3.17459473
77rRNA metabolic process (GO:0016072)3.17090477
78protein complex biogenesis (GO:0070271)3.12134311
79mitochondrial respiratory chain complex assembly (GO:0033108)3.10926029
80negative regulation of ligase activity (GO:0051352)3.10040046
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10040046
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09670325
83nuclear pore complex assembly (GO:0051292)3.07774402
84kinetochore organization (GO:0051383)3.04271054
85pseudouridine synthesis (GO:0001522)3.04110733
86negative regulation of chromosome segregation (GO:0051985)3.03463003
87regulation of centriole replication (GO:0046599)3.03214654
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03079789
89histone mRNA metabolic process (GO:0008334)3.02671029
90maturation of 5.8S rRNA (GO:0000460)3.01993696
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.00953837
92protein localization to chromosome (GO:0034502)3.00330491
93regulation of chromosome segregation (GO:0051983)2.99579039
94recombinational repair (GO:0000725)2.99086790
95negative regulation of mitotic sister chromatid separation (GO:2000816)2.98019860
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98019860
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98019860
98negative regulation of sister chromatid segregation (GO:0033046)2.98019860
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.97776162
100termination of RNA polymerase III transcription (GO:0006386)2.97776162
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96359648
102double-strand break repair via homologous recombination (GO:0000724)2.96130535
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93247727
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93247727
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93247727
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92729196
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91831527
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91757236
109spindle checkpoint (GO:0031577)2.91675805
110double-strand break repair via nonhomologous end joining (GO:0006303)2.91546793
111non-recombinational repair (GO:0000726)2.91546793
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91058353
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90833112
114meiotic chromosome segregation (GO:0045132)2.90801839
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90779844
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90779844
117positive regulation of chromosome segregation (GO:0051984)2.90341845
118establishment of integrated proviral latency (GO:0075713)2.90067194
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.89483101
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89483101
121spindle assembly checkpoint (GO:0071173)2.88948126
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88857405
123translesion synthesis (GO:0019985)2.88840125
124DNA duplex unwinding (GO:0032508)2.88644242
125nuclear envelope organization (GO:0006998)2.88285120
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87901030
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87901030
128DNA geometric change (GO:0032392)2.87819917
129chromatin assembly or disassembly (GO:0006333)2.87800022
130respiratory chain complex IV assembly (GO:0008535)2.87797156
131mitotic spindle assembly checkpoint (GO:0007094)2.87390041
132rRNA modification (GO:0000154)2.87300718
133postreplication repair (GO:0006301)2.85743642
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85543497
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.85543497
136NADH dehydrogenase complex assembly (GO:0010257)2.85543497
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84255415
138proteasome assembly (GO:0043248)2.84116005
139maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83815424
140regulation of cellular amino acid metabolic process (GO:0006521)2.83774369
141cellular protein complex disassembly (GO:0043624)2.83717178
142kinetochore assembly (GO:0051382)2.82279888
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82001019
144folic acid metabolic process (GO:0046655)2.81696045
145cotranslational protein targeting to membrane (GO:0006613)2.81661613
146protein targeting to ER (GO:0045047)2.80557962
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79728943
148G1/S transition of mitotic cell cycle (GO:0000082)2.79559218
149cell cycle G1/S phase transition (GO:0044843)2.79559218
150regulation of centrosome cycle (GO:0046605)2.78627702
151negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78419786
152mitotic spindle checkpoint (GO:0071174)2.77714639
153regulation of mitotic spindle organization (GO:0060236)2.77387541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70056118
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20361420
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.93755759
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72530044
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42107322
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11551831
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88813684
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88556724
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.87975252
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85349838
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84458498
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78007987
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76844119
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.72323116
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.64906115
16ZNF274_21170338_ChIP-Seq_K562_Hela2.55503139
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53645667
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.53424800
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45567829
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31036690
21XRN2_22483619_ChIP-Seq_HELA_Human2.29530310
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24071728
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16357041
24* VDR_23849224_ChIP-Seq_CD4+_Human2.14583617
25EWS_26573619_Chip-Seq_HEK293_Human2.12726409
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08999871
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.01130447
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98141493
29DCP1A_22483619_ChIP-Seq_HELA_Human1.94802615
30GABP_19822575_ChIP-Seq_HepG2_Human1.94393578
31VDR_22108803_ChIP-Seq_LS180_Human1.93501222
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92212888
33AR_21909140_ChIP-Seq_LNCAP_Human1.90539645
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89601791
35FUS_26573619_Chip-Seq_HEK293_Human1.87634550
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83496599
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83496102
38MYC_22102868_ChIP-Seq_BL_Human1.82742273
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82140013
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.81025682
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80556324
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76989173
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73517748
44TTF2_22483619_ChIP-Seq_HELA_Human1.71927286
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.70004637
46* CIITA_25753668_ChIP-Seq_RAJI_Human1.68006272
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67206217
48* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64270617
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62516838
50KDM5A_27292631_Chip-Seq_BREAST_Human1.58421560
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.58129082
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55502754
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51113485
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48679750
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.46717425
56* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46640652
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46419502
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45791967
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45497748
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41981719
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.40162357
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39153387
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37067177
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36829580
65P300_19829295_ChIP-Seq_ESCs_Human1.35613740
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35579735
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35141148
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34277524
69IGF1R_20145208_ChIP-Seq_DFB_Human1.32857217
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32055312
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30641032
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29705605
73ELK1_19687146_ChIP-ChIP_HELA_Human1.29303699
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28317980
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27011358
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26414573
77TAF15_26573619_Chip-Seq_HEK293_Human1.25887473
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24819307
79IRF1_19129219_ChIP-ChIP_H3396_Human1.24140875
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22536548
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20452291
82VDR_21846776_ChIP-Seq_THP-1_Human1.18642267
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17189852
84* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16862399
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15681644
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14152153
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.13790468
88ER_23166858_ChIP-Seq_MCF-7_Human1.11155873
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.09354419
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09322339
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08757936
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08247945
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07876205
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07759613
95* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07195607
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06938110
97GBX2_23144817_ChIP-Seq_PC3_Human1.06161126
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06143074
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05812328
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05092293
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04992302
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04943904
103* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04500433
104TP53_22573176_ChIP-Seq_HFKS_Human1.04046403
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.03857505
106* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03336878
107TFEB_21752829_ChIP-Seq_HELA_Human1.03261976
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02426082
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99759227
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.99320134
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.99085202
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98344820
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97951017
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97816044
115MYC_18940864_ChIP-ChIP_HL60_Human0.96131513
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95099931
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94066612
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93901220
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93043167
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92792090
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92625215
122SPI1_23547873_ChIP-Seq_NB4_Human0.92577714
123NANOG_19829295_ChIP-Seq_ESCs_Human0.92025832
124SOX2_19829295_ChIP-Seq_ESCs_Human0.92025832
125CBP_20019798_ChIP-Seq_JUKART_Human0.88702233
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88702233
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88342202
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88139283
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87468986
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.87468986
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85961481
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85089253
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85050372
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.84192506
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.83678398
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83227208
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82330897
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80759344
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77627883
140* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75718478
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74865674
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73473517
143FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73341574
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72243586
145UTX_26944678_Chip-Seq_JUKART_Human0.72114988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.25961776
2MP0010094_abnormal_chromosome_stability4.44476579
3MP0003111_abnormal_nucleus_morphology4.34616656
4MP0004957_abnormal_blastocyst_morpholog4.30147155
5MP0003077_abnormal_cell_cycle3.89276177
6MP0008057_abnormal_DNA_replication3.49916194
7MP0008058_abnormal_DNA_repair3.03165400
8MP0008007_abnormal_cellular_replicative2.90691701
9MP0002396_abnormal_hematopoietic_system2.83922013
10MP0000372_irregular_coat_pigmentation2.57534017
11MP0008932_abnormal_embryonic_tissue2.48224874
12MP0001730_embryonic_growth_arrest2.31024087
13MP0002102_abnormal_ear_morphology2.21622707
14MP0000350_abnormal_cell_proliferation2.17863726
15MP0002938_white_spotting2.17371326
16MP0010352_gastrointestinal_tract_polyps2.09789458
17MP0008877_abnormal_DNA_methylation2.09183737
18MP0003195_calcinosis2.02441049
19MP0003786_premature_aging1.94618668
20MP0003806_abnormal_nucleotide_metabolis1.86291948
21MP0003123_paternal_imprinting1.84329615
22MP0001697_abnormal_embryo_size1.84125044
23MP0010307_abnormal_tumor_latency1.80331239
24MP0001672_abnormal_embryogenesis/_devel1.79688618
25MP0005380_embryogenesis_phenotype1.79688618
26MP0000569_abnormal_digit_pigmentation1.78098238
27MP0000490_abnormal_crypts_of1.73021699
28MP0005360_urolithiasis1.71445580
29MP0002080_prenatal_lethality1.66029287
30MP0003984_embryonic_growth_retardation1.63973570
31MP0008789_abnormal_olfactory_epithelium1.63972415
32MP0004808_abnormal_hematopoietic_stem1.63376435
33MP0005397_hematopoietic_system_phenotyp1.59797246
34MP0001545_abnormal_hematopoietic_system1.59797246
35MP0002019_abnormal_tumor_incidence1.58861876
36MP0006072_abnormal_retinal_apoptosis1.58416045
37MP0002088_abnormal_embryonic_growth/wei1.58393136
38MP0009333_abnormal_splenocyte_physiolog1.56823063
39MP0003787_abnormal_imprinting1.56021972
40MP0003718_maternal_effect1.54983411
41MP0000313_abnormal_cell_death1.50754847
42MP0001293_anophthalmia1.49808148
43MP0002085_abnormal_embryonic_tissue1.46729852
44MP0002086_abnormal_extraembryonic_tissu1.43716678
45MP0001929_abnormal_gametogenesis1.43274770
46MP0005367_renal/urinary_system_phenotyp1.42056134
47MP0000516_abnormal_urinary_system1.42056134
48MP0003136_yellow_coat_color1.41675272
49MP0002210_abnormal_sex_determination1.41455746
50MP0004147_increased_porphyrin_level1.40021425
51MP0002084_abnormal_developmental_patter1.36616351
52MP0002837_dystrophic_cardiac_calcinosis1.36309045
53MP0003763_abnormal_thymus_physiology1.35917301
54MP0002751_abnormal_autonomic_nervous1.34192839
55MP0000358_abnormal_cell_content/1.31569629
56MP0003937_abnormal_limbs/digits/tail_de1.30607553
57MP0002398_abnormal_bone_marrow1.29166685
58MP0000703_abnormal_thymus_morphology1.28334172
59MP0001145_abnormal_male_reproductive1.27974271
60MP0002234_abnormal_pharynx_morphology1.27485027
61MP0003122_maternal_imprinting1.27006837
62MP0005408_hypopigmentation1.25717276
63MP0005253_abnormal_eye_physiology1.21320865
64MP0002736_abnormal_nociception_after1.20781451
65MP0002722_abnormal_immune_system1.20708909
66MP0000689_abnormal_spleen_morphology1.19923343
67MP0002163_abnormal_gland_morphology1.19558289
68MP0004197_abnormal_fetal_growth/weight/1.17536916
69MP0001529_abnormal_vocalization1.17102253
70MP0006035_abnormal_mitochondrial_morpho1.16901759
71MP0001485_abnormal_pinna_reflex1.14465855
72MP0005410_abnormal_fertilization1.13994030
73MP0005395_other_phenotype1.13831610
74MP0002132_abnormal_respiratory_system1.12021708
75MP0005646_abnormal_pituitary_gland1.10538090
76MP0000653_abnormal_sex_gland1.10447354
77MP0002653_abnormal_ependyma_morphology1.10053903
78MP0001661_extended_life_span1.07148683
79MP0002090_abnormal_vision1.07072010
80MP0003567_abnormal_fetal_cardiomyocyte1.05951816
81MP0006292_abnormal_olfactory_placode1.05932488
82MP0003646_muscle_fatigue1.03547955
83MP0005551_abnormal_eye_electrophysiolog1.02886261
84MP0001915_intracranial_hemorrhage1.02386656
85MP0005075_abnormal_melanosome_morpholog1.02279970
86MP0005499_abnormal_olfactory_system1.02222271
87MP0005394_taste/olfaction_phenotype1.02222271
88MP0002429_abnormal_blood_cell1.01221160
89MP0009672_abnormal_birth_weight0.99554491
90MP0005645_abnormal_hypothalamus_physiol0.98103388
91MP0005379_endocrine/exocrine_gland_phen0.97435333
92MP0000427_abnormal_hair_cycle0.96584529
93MP0005076_abnormal_cell_differentiation0.95708920
94MP0003221_abnormal_cardiomyocyte_apopto0.94803217
95MP0003890_abnormal_embryonic-extraembry0.94605995
96MP0008872_abnormal_physiological_respon0.93391075
97MP0005084_abnormal_gallbladder_morpholo0.92873348
98MP0005171_absent_coat_pigmentation0.91688501
99MP0000631_abnormal_neuroendocrine_gland0.91681302
100MP0010234_abnormal_vibrissa_follicle0.91635972
101MP0003698_abnormal_male_reproductive0.91589922
102MP0000647_abnormal_sebaceous_gland0.90917485
103MP0002233_abnormal_nose_morphology0.90815084
104MP0006036_abnormal_mitochondrial_physio0.89691061
105MP0000716_abnormal_immune_system0.87857959
106MP0009278_abnormal_bone_marrow0.87122232
107MP0004133_heterotaxia0.86252624
108MP0006054_spinal_hemorrhage0.85703154
109MP0000858_altered_metastatic_potential0.85687413
110MP0002095_abnormal_skin_pigmentation0.85370032
111MP0002160_abnormal_reproductive_system0.85299855
112MP0000015_abnormal_ear_pigmentation0.85115898
113MP0001984_abnormal_olfaction0.85045386
114MP0001968_abnormal_touch/_nociception0.84954421
115MP0008995_early_reproductive_senescence0.83522309
116MP0010030_abnormal_orbit_morphology0.82415476
117MP0005671_abnormal_response_to0.82292491
118MP0008875_abnormal_xenobiotic_pharmacok0.82260975
119MP0005384_cellular_phenotype0.81492730
120MP0009697_abnormal_copulation0.80962124
121MP0005389_reproductive_system_phenotype0.80200868
122MP0003119_abnormal_digestive_system0.80195157
123MP0001853_heart_inflammation0.79586529
124MP0005332_abnormal_amino_acid0.79141842
125MP0001324_abnormal_eye_pigmentation0.78598993
126MP0005023_abnormal_wound_healing0.78383336
127MP0001286_abnormal_eye_development0.78086646
128MP0001119_abnormal_female_reproductive0.77334745
129MP0009046_muscle_twitch0.76681555
130MP0003186_abnormal_redox_activity0.75267161
131MP0002161_abnormal_fertility/fecundity0.74838536
132MP0005220_abnormal_exocrine_pancreas0.74357069
133MP0005174_abnormal_tail_pigmentation0.72947874
134MP0001835_abnormal_antigen_presentation0.72843590
135MP0001800_abnormal_humoral_immune0.72435146
136MP0005391_vision/eye_phenotype0.71278468
137MP0005621_abnormal_cell_physiology0.70473986
138MP0004233_abnormal_muscle_weight0.69353153
139MP0000598_abnormal_liver_morphology0.68363698
140MP0009053_abnormal_anal_canal0.67619210
141MP0002111_abnormal_tail_morphology0.67366441
142MP0000477_abnormal_intestine_morphology0.65206574
143MP0002420_abnormal_adaptive_immunity0.64721441
144MP0002092_abnormal_eye_morphology0.64479070
145MP0009840_abnormal_foam_cell0.64256570
146MP0001819_abnormal_immune_cell0.63480801
147MP0003941_abnormal_skin_development0.63282775
148MP0000685_abnormal_immune_system0.61545082
149MP0003315_abnormal_perineum_morphology0.61162292
150MP0005266_abnormal_metabolism0.60993352
151MP0001764_abnormal_homeostasis0.60046225
152MP0002269_muscular_atrophy0.59937999
153MP0001919_abnormal_reproductive_system0.59857221
154MP0003121_genomic_imprinting0.59827669
155MP0000465_gastrointestinal_hemorrhage0.58453758

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.58082179
2Abnormality of cells of the erythroid lineage (HP:0012130)4.25049473
3Abnormal number of erythroid precursors (HP:0012131)4.20529309
4Reticulocytopenia (HP:0001896)3.98951063
5Oral leukoplakia (HP:0002745)3.75768830
6Aplastic anemia (HP:0001915)3.62858315
7Selective tooth agenesis (HP:0001592)3.37836027
8Patellar aplasia (HP:0006443)3.37135134
9Impulsivity (HP:0100710)3.36828181
10Breast hypoplasia (HP:0003187)3.35316245
11Chromsome breakage (HP:0040012)3.27213333
12Aplasia/Hypoplasia of the patella (HP:0006498)3.15618479
13Degeneration of anterior horn cells (HP:0002398)3.06936357
14Abnormality of the anterior horn cell (HP:0006802)3.06936357
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99125600
16Acute necrotizing encephalopathy (HP:0006965)2.98237352
17Carpal bone hypoplasia (HP:0001498)2.96360882
18Myelodysplasia (HP:0002863)2.96287933
19Increased CSF lactate (HP:0002490)2.95017987
20Acute encephalopathy (HP:0006846)2.94698169
21Cerebral hypomyelination (HP:0006808)2.92739224
22Multiple enchondromatosis (HP:0005701)2.86048139
23Rough bone trabeculation (HP:0100670)2.85280146
24Colon cancer (HP:0003003)2.80050256
25Methylmalonic acidemia (HP:0002912)2.79274445
26Macrocytic anemia (HP:0001972)2.76441413
27Meckel diverticulum (HP:0002245)2.75264867
28Ependymoma (HP:0002888)2.74219339
29Medulloblastoma (HP:0002885)2.73442281
30Absent thumb (HP:0009777)2.71313991
31Mitochondrial inheritance (HP:0001427)2.70863514
32Abnormality of the preputium (HP:0100587)2.68873667
33Abnormality of chromosome stability (HP:0003220)2.66810685
34Progressive macrocephaly (HP:0004481)2.66419065
35Abnormal mitochondria in muscle tissue (HP:0008316)2.65878406
36Abnormality of the ileum (HP:0001549)2.65158629
37Bone marrow hypocellularity (HP:0005528)2.64320754
38Pancreatic islet-cell hyperplasia (HP:0004510)2.62896686
39Increased hepatocellular lipid droplets (HP:0006565)2.61817517
40Pancreatic cysts (HP:0001737)2.57919833
41Abnormal lung lobation (HP:0002101)2.55372811
42Thrombocytosis (HP:0001894)2.54184251
43Agnosia (HP:0010524)2.54063699
44Pallor (HP:0000980)2.53288460
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.51649519
46Microretrognathia (HP:0000308)2.51504289
47Lipid accumulation in hepatocytes (HP:0006561)2.51489261
48Neoplasm of the pancreas (HP:0002894)2.48895452
49Cellular immunodeficiency (HP:0005374)2.47701995
50Hepatic necrosis (HP:0002605)2.46282053
51Methylmalonic aciduria (HP:0012120)2.43703736
52Premature graying of hair (HP:0002216)2.42967447
53Hyperglycinemia (HP:0002154)2.41008723
54Basal cell carcinoma (HP:0002671)2.39350554
55Small intestinal stenosis (HP:0012848)2.39332778
56Duodenal stenosis (HP:0100867)2.39332778
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38502556
58Premature ovarian failure (HP:0008209)2.37654295
59Hepatocellular necrosis (HP:0001404)2.36750007
60Cleft eyelid (HP:0000625)2.36715590
61Pancreatic fibrosis (HP:0100732)2.36458431
62Squamous cell carcinoma (HP:0002860)2.33547277
63Trismus (HP:0000211)2.32080573
64Abnormality of methionine metabolism (HP:0010901)2.30935606
6511 pairs of ribs (HP:0000878)2.28751274
66Volvulus (HP:0002580)2.28526552
67Abnormality of midbrain morphology (HP:0002418)2.26983924
68Molar tooth sign on MRI (HP:0002419)2.26983924
69Abnormality of pyrimidine metabolism (HP:0004353)2.26948039
70Secondary amenorrhea (HP:0000869)2.26839485
71Intestinal atresia (HP:0011100)2.26550453
72Glioma (HP:0009733)2.23847930
73Type I transferrin isoform profile (HP:0003642)2.23228458
74Abnormality of the astrocytes (HP:0100707)2.22930931
75Astrocytoma (HP:0009592)2.22930931
76Atresia of the external auditory canal (HP:0000413)2.22484404
77Clubbing of toes (HP:0100760)2.21157936
78Rhabdomyosarcoma (HP:0002859)2.18145563
79Cerebral edema (HP:0002181)2.17716146
80Neoplasm of the adrenal cortex (HP:0100641)2.15378520
81Sloping forehead (HP:0000340)2.14850363
82Progressive muscle weakness (HP:0003323)2.14019753
83Pancytopenia (HP:0001876)2.12589306
84Microvesicular hepatic steatosis (HP:0001414)2.11046979
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.09517811
86Neoplasm of the adrenal gland (HP:0100631)2.09300861
87Abnormality of serum amino acid levels (HP:0003112)2.08187391
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07346623
89Renal cortical cysts (HP:0000803)2.06563662
90Hypothermia (HP:0002045)2.05678311
91Lymphoma (HP:0002665)2.04668914
92Hypoglycemic coma (HP:0001325)2.04545181
93Medial flaring of the eyebrow (HP:0010747)2.02455390
94Nephronophthisis (HP:0000090)2.02245175
95Absent radius (HP:0003974)2.02230591
96Embryonal renal neoplasm (HP:0011794)2.01860422
97Abnormality of the carotid arteries (HP:0005344)2.01482437
98Amaurosis fugax (HP:0100576)1.99778357
99Abnormality of reticulocytes (HP:0004312)1.99389996
100Renal Fanconi syndrome (HP:0001994)1.99167674
101Abnormality of the duodenum (HP:0002246)1.99074754
102Progressive inability to walk (HP:0002505)1.98729971
103Supernumerary spleens (HP:0009799)1.98224076
104Tracheoesophageal fistula (HP:0002575)1.97997241
105Median cleft lip (HP:0000161)1.96718928
106Pendular nystagmus (HP:0012043)1.96055276
107Proximal placement of thumb (HP:0009623)1.95005657
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93812168
109Abnormality of the pons (HP:0007361)1.92551475
110Cafe-au-lait spot (HP:0000957)1.92546962
111Lactic acidosis (HP:0003128)1.91973184
112True hermaphroditism (HP:0010459)1.91860294
113Hypoplasia of the pons (HP:0012110)1.91414461
114Deviation of the thumb (HP:0009603)1.91202069
115Prominent nose (HP:0000448)1.90228753
116Abnormality of vitamin B metabolism (HP:0004340)1.90133821
117Hyperinsulinemic hypoglycemia (HP:0000825)1.90032210
118Tongue fasciculations (HP:0001308)1.89697387
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89209244
120Abnormal protein N-linked glycosylation (HP:0012347)1.89209244
121Abnormal protein glycosylation (HP:0012346)1.89209244
122Abnormal glycosylation (HP:0012345)1.89209244
123Muscle fiber atrophy (HP:0100295)1.88371517
124Short tibia (HP:0005736)1.87899017
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.87849056
126Abnormal spermatogenesis (HP:0008669)1.87285581
127Bifid tongue (HP:0010297)1.87171104
128Duplicated collecting system (HP:0000081)1.87121846
129Horseshoe kidney (HP:0000085)1.87049120
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.86754005
131Abnormality of the renal cortex (HP:0011035)1.86739645
132Absent eyelashes (HP:0000561)1.86340692
133Hypobetalipoproteinemia (HP:0003563)1.85778288
134Increased nuchal translucency (HP:0010880)1.84793953
135Personality changes (HP:0000751)1.84519487
136Abnormal number of incisors (HP:0011064)1.83926637
137Congenital, generalized hypertrichosis (HP:0004540)1.83495846
138Abnormal trabecular bone morphology (HP:0100671)1.83125727
139Abnormality of the renal collecting system (HP:0004742)1.82963157
140Abolished electroretinogram (ERG) (HP:0000550)1.82629151
141IgM deficiency (HP:0002850)1.82551241
142Lethargy (HP:0001254)1.82443472
143Aplasia involving forearm bones (HP:0009822)1.81102431
144Absent forearm bone (HP:0003953)1.81102431
145Slender long bone (HP:0003100)1.80588990
146Facial cleft (HP:0002006)1.80524619
147Neoplasm of the colon (HP:0100273)1.80286579
148Increased serum lactate (HP:0002151)1.78696199
149Missing ribs (HP:0000921)1.78149128
150Abnormality of serine family amino acid metabolism (HP:0010894)1.77871967
151Abnormality of glycine metabolism (HP:0010895)1.77871967
152Abdominal situs inversus (HP:0003363)1.75675303
153Abnormality of abdominal situs (HP:0011620)1.75675303
154Ectopic kidney (HP:0000086)1.75569537
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75340464
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75340464
157Triphalangeal thumb (HP:0001199)1.75308766
158Abnormality of the labia minora (HP:0012880)1.75299440
159Nephroblastoma (Wilms tumor) (HP:0002667)1.75087030
160Dandy-Walker malformation (HP:0001305)1.75085363
1613-Methylglutaconic aciduria (HP:0003535)1.74460319
162Small hand (HP:0200055)1.74134787
163Glossoptosis (HP:0000162)1.73628294
164Type 2 muscle fiber atrophy (HP:0003554)1.73610720
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72021696
166Abnormality of alanine metabolism (HP:0010916)1.70945162
167Hyperalaninemia (HP:0003348)1.70945162
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70945162
169Poikiloderma (HP:0001029)1.70297096
170Muscle fibrillation (HP:0010546)1.67999268
171Pulmonary fibrosis (HP:0002206)1.66464492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.82203751
2WEE14.19573034
3CDC73.69567686
4BMPR1B3.31372416
5FRK2.95102440
6EIF2AK12.88161445
7NEK22.74658840
8NUAK12.59920179
9TRIM282.47328689
10MST42.41757925
11BRSK22.40441308
12PLK42.29537603
13VRK22.24318199
14TTK2.22813659
15TAF12.15518997
16AKT32.10702845
17TESK22.05726212
18WNK31.99828049
19TSSK61.99513231
20NME21.98553649
21PLK11.96063416
22SRPK11.93881295
23EEF2K1.91110041
24PBK1.87184697
25NEK11.80389828
26ACVR1B1.79934137
27STK161.76855624
28CDK71.72080186
29AURKB1.66334114
30TLK11.62954066
31MAP4K21.60103835
32BRSK11.59297733
33MKNK11.57440623
34PIM21.57092998
35ERBB31.55081020
36BRAF1.54217667
37FLT31.52260410
38ATR1.50703757
39EIF2AK31.50191953
40STK391.44802051
41RPS6KB21.43643562
42STK101.40111514
43PASK1.39924856
44INSRR1.39050731
45DYRK31.38574579
46MAP4K11.38458318
47CHEK21.35002281
48PLK21.34725065
49CDK41.34110899
50CDK121.33099311
51VRK11.30362012
52PDK31.29711787
53PDK41.29711787
54TESK11.29124268
55TNIK1.28560797
56MAP3K81.27441351
57AURKA1.27044090
58GRK11.23633539
59OXSR11.20870666
60PKN21.18985527
61CCNB11.16338194
62CSNK1G11.14022398
63MAP3K101.13868026
64PLK31.12779384
65SCYL21.12466525
66PAK41.11472613
67EPHA21.09742300
68CHEK11.09471487
69RPS6KA41.08037320
70MKNK21.06616293
71PIM11.06195025
72MAP3K111.05191032
73BCR1.03620843
74CSNK1G30.98237736
75PNCK0.97808222
76BCKDK0.91891365
77CSNK1G20.86783536
78MAPK130.86711385
79KDR0.86334357
80STK40.84377093
81CSNK1A1L0.83861371
82FGFR20.83120463
83PAK10.82264010
84ADRBK20.80377065
85CDK20.79263397
86ATM0.78014155
87MAP2K30.76665418
88WNK40.75112534
89TGFBR10.74570535
90GRK60.73537170
91ZAK0.72016999
92ZAP700.69571860
93BTK0.65758031
94CDK90.64891486
95ALK0.63112065
96EIF2AK20.61899887
97MAPKAPK30.61572597
98CSNK2A10.61069573
99CDK60.61036595
100CSNK2A20.59502806
101LRRK20.55463131
102CDK10.53692123
103NEK90.53483854
104PRKCI0.53207721
105ICK0.52788862
106TAOK30.50340570
107CASK0.50024864
108CLK10.49457709
109RAF10.49365577
110PRKCE0.45137479
111MTOR0.45079390
112PDK20.44429886
113DYRK20.43500827
114ILK0.43334365
115PRKCG0.43284790
116CDK80.41007289
117JAK30.40668647
118LATS20.40165147
119MUSK0.39848983
120CSF1R0.39581632
121PAK20.38526786
122CSNK1A10.36614269
123STK30.36110586
124ERBB40.35056373
125DAPK10.34948366
126FGFR10.34930778
127FER0.34034828
128PINK10.33381635
129MAP3K120.31622275
130MAPK110.30275462
131TAOK20.30111490
132NLK0.29618814
133BRD40.29411714
134CSNK1D0.29392320
135CSNK1E0.29213377
136MELK0.28280509
137SIK30.26086021
138MAP3K40.25961542
139MAP3K30.25694745
140RPS6KA50.25448133
141PAK30.25174433
142NME10.24962875
143STK38L0.24881892
144MAP3K60.24572430
145AKT20.24257513
146MARK30.24246685
147CDK30.24052354
148PRKDC0.23530037
149TRIB30.23075018
150TXK0.23037559
151PHKG20.19012936

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83871705
2Mismatch repair_Homo sapiens_hsa034303.90397556
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68535337
4Ribosome_Homo sapiens_hsa030103.33715109
5Base excision repair_Homo sapiens_hsa034103.19156582
6Spliceosome_Homo sapiens_hsa030403.13591010
7RNA transport_Homo sapiens_hsa030133.12211747
8Proteasome_Homo sapiens_hsa030503.03825026
9RNA polymerase_Homo sapiens_hsa030202.92549023
10Homologous recombination_Homo sapiens_hsa034402.90781844
11One carbon pool by folate_Homo sapiens_hsa006702.67861000
12Cell cycle_Homo sapiens_hsa041102.58407979
13Nucleotide excision repair_Homo sapiens_hsa034202.56559534
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40958722
15Pyrimidine metabolism_Homo sapiens_hsa002402.35907858
16Oxidative phosphorylation_Homo sapiens_hsa001902.15123929
17Propanoate metabolism_Homo sapiens_hsa006402.14934237
18Fanconi anemia pathway_Homo sapiens_hsa034602.03772816
19RNA degradation_Homo sapiens_hsa030181.94084839
20Non-homologous end-joining_Homo sapiens_hsa034501.92941505
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92527545
22Parkinsons disease_Homo sapiens_hsa050121.87375465
23Basal transcription factors_Homo sapiens_hsa030221.82713662
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80970341
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72992241
26* mRNA surveillance pathway_Homo sapiens_hsa030151.59978353
27p53 signaling pathway_Homo sapiens_hsa041151.56685770
28Fatty acid elongation_Homo sapiens_hsa000621.40822225
29Vitamin B6 metabolism_Homo sapiens_hsa007501.35817520
30Biosynthesis of amino acids_Homo sapiens_hsa012301.34562539
31Steroid biosynthesis_Homo sapiens_hsa001001.31794741
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.26583952
33Butanoate metabolism_Homo sapiens_hsa006501.24830885
34Purine metabolism_Homo sapiens_hsa002301.24352141
35Pentose phosphate pathway_Homo sapiens_hsa000301.21918168
36Epstein-Barr virus infection_Homo sapiens_hsa051691.15534243
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10729516
38Selenocompound metabolism_Homo sapiens_hsa004501.10628468
39Systemic lupus erythematosus_Homo sapiens_hsa053221.10359483
40Alzheimers disease_Homo sapiens_hsa050101.10090843
41Caffeine metabolism_Homo sapiens_hsa002321.09943023
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06809339
43Sulfur relay system_Homo sapiens_hsa041221.04432310
44Folate biosynthesis_Homo sapiens_hsa007901.01198410
45Antigen processing and presentation_Homo sapiens_hsa046120.99284256
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.99277781
47Herpes simplex infection_Homo sapiens_hsa051680.97631018
48Tryptophan metabolism_Homo sapiens_hsa003800.96370829
49Sulfur metabolism_Homo sapiens_hsa009200.95169645
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.93229434
51Peroxisome_Homo sapiens_hsa041460.91389151
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90346813
53Phototransduction_Homo sapiens_hsa047440.89837016
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89335762
55Viral carcinogenesis_Homo sapiens_hsa052030.87745892
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86457871
57Oocyte meiosis_Homo sapiens_hsa041140.86092558
58Thyroid cancer_Homo sapiens_hsa052160.85847856
59Nitrogen metabolism_Homo sapiens_hsa009100.85251925
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.84073155
61Carbon metabolism_Homo sapiens_hsa012000.83303353
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83170100
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81420486
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80939124
65Primary immunodeficiency_Homo sapiens_hsa053400.79497770
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73388238
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73015841
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72278254
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71998288
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71327685
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68872260
72HTLV-I infection_Homo sapiens_hsa051660.68018073
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65586483
74Fatty acid metabolism_Homo sapiens_hsa012120.63782810
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63683933
76Fatty acid degradation_Homo sapiens_hsa000710.59517298
77Vitamin digestion and absorption_Homo sapiens_hsa049770.59266076
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58949941
79Legionellosis_Homo sapiens_hsa051340.57502229
80Fructose and mannose metabolism_Homo sapiens_hsa000510.54648450
81beta-Alanine metabolism_Homo sapiens_hsa004100.51757551
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48058997
83Chemical carcinogenesis_Homo sapiens_hsa052040.47845311
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47640013
85Glutathione metabolism_Homo sapiens_hsa004800.46594929
86Acute myeloid leukemia_Homo sapiens_hsa052210.45583349
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44858276
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44686614
89Retinol metabolism_Homo sapiens_hsa008300.44056679
90Collecting duct acid secretion_Homo sapiens_hsa049660.42705591
91Galactose metabolism_Homo sapiens_hsa000520.41569989
92Ether lipid metabolism_Homo sapiens_hsa005650.41426347
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41393023
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40990381
95Colorectal cancer_Homo sapiens_hsa052100.39515842
96Measles_Homo sapiens_hsa051620.39190573
97Huntingtons disease_Homo sapiens_hsa050160.39188294
98Bladder cancer_Homo sapiens_hsa052190.36191612
99MicroRNAs in cancer_Homo sapiens_hsa052060.34843310
100Small cell lung cancer_Homo sapiens_hsa052220.34694301
101N-Glycan biosynthesis_Homo sapiens_hsa005100.33922548
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.33894839
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33801159
104Protein export_Homo sapiens_hsa030600.33031760
105Cardiac muscle contraction_Homo sapiens_hsa042600.32459805
106Olfactory transduction_Homo sapiens_hsa047400.32301862
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.31711104
108Linoleic acid metabolism_Homo sapiens_hsa005910.31462387
109Apoptosis_Homo sapiens_hsa042100.31450255
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.30850032
111Regulation of autophagy_Homo sapiens_hsa041400.28386897
112Shigellosis_Homo sapiens_hsa051310.28262467
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.28157810
114Pyruvate metabolism_Homo sapiens_hsa006200.26944658
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.26930953
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25725205
117Metabolic pathways_Homo sapiens_hsa011000.24912878
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24504840
119Basal cell carcinoma_Homo sapiens_hsa052170.24345959
120Influenza A_Homo sapiens_hsa051640.23999328
121Allograft rejection_Homo sapiens_hsa053300.23997189
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23813000
123HIF-1 signaling pathway_Homo sapiens_hsa040660.22401050
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22059638
125mTOR signaling pathway_Homo sapiens_hsa041500.21863427
126Hepatitis B_Homo sapiens_hsa051610.20842514
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20617808
128Lysine degradation_Homo sapiens_hsa003100.20491468
129Chronic myeloid leukemia_Homo sapiens_hsa052200.20148437
130Alcoholism_Homo sapiens_hsa050340.17580571
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17535312
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17157013
133Notch signaling pathway_Homo sapiens_hsa043300.15783295
134Hippo signaling pathway_Homo sapiens_hsa043900.14986379
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13936333
136Arginine and proline metabolism_Homo sapiens_hsa003300.13152482
137Hematopoietic cell lineage_Homo sapiens_hsa046400.12672717
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11982052
139TGF-beta signaling pathway_Homo sapiens_hsa043500.11562460
140Viral myocarditis_Homo sapiens_hsa054160.09739410
141Hedgehog signaling pathway_Homo sapiens_hsa043400.08857723
142Pathways in cancer_Homo sapiens_hsa052000.08769521
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08670532

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