CSTF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)5.91859714
2proline biosynthetic process (GO:0006561)5.81771158
3maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.19946672
4viral mRNA export from host cell nucleus (GO:0046784)5.06974139
5transcription from mitochondrial promoter (GO:0006390)4.98545395
6DNA strand renaturation (GO:0000733)4.90982618
7somatic hypermutation of immunoglobulin genes (GO:0016446)4.74393760
8somatic diversification of immune receptors via somatic mutation (GO:0002566)4.74393760
9embryonic process involved in female pregnancy (GO:0060136)4.73409217
10DNA double-strand break processing (GO:0000729)4.57502987
11positive regulation of protein homooligomerization (GO:0032464)4.40678399
12DNA deamination (GO:0045006)4.38429142
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.36879407
14meiotic chromosome segregation (GO:0045132)4.33393400
15formation of translation preinitiation complex (GO:0001731)4.32481679
16telomere maintenance via semi-conservative replication (GO:0032201)4.29660092
17chromatin remodeling at centromere (GO:0031055)4.25841877
18CENP-A containing nucleosome assembly (GO:0034080)4.16085289
19proline metabolic process (GO:0006560)4.10063563
20spliceosomal tri-snRNP complex assembly (GO:0000244)4.06075621
21maturation of 5.8S rRNA (GO:0000460)4.05277294
22poly(A)+ mRNA export from nucleus (GO:0016973)4.03536339
23establishment of integrated proviral latency (GO:0075713)3.95255837
24establishment of apical/basal cell polarity (GO:0035089)3.90095674
25regulation of double-strand break repair via homologous recombination (GO:0010569)3.81645618
26kinetochore assembly (GO:0051382)3.81471510
27negative regulation of mRNA processing (GO:0050686)3.80315978
28DNA strand elongation involved in DNA replication (GO:0006271)3.79840121
29DNA ligation (GO:0006266)3.78729798
30kinetochore organization (GO:0051383)3.76921235
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.76069552
32DNA damage response, detection of DNA damage (GO:0042769)3.75040168
33histone exchange (GO:0043486)3.72991083
34telomere maintenance via recombination (GO:0000722)3.72073183
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68300669
36DNA topological change (GO:0006265)3.66111526
37base-excision repair (GO:0006284)3.64585032
38* termination of RNA polymerase II transcription (GO:0006369)3.63055618
39regulation of helicase activity (GO:0051095)3.62846262
40negative regulation of RNA splicing (GO:0033119)3.62014873
41DNA strand elongation (GO:0022616)3.60109685
42establishment or maintenance of monopolar cell polarity (GO:0061339)3.57241285
43establishment of monopolar cell polarity (GO:0061162)3.57241285
44DNA integration (GO:0015074)3.55052650
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.54484115
46DNA replication checkpoint (GO:0000076)3.54012339
47muscle organ morphogenesis (GO:0048644)3.52246488
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50516558
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50516558
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.50516558
51DNA replication-dependent nucleosome organization (GO:0034723)3.49588369
52DNA replication-dependent nucleosome assembly (GO:0006335)3.49588369
53oxidative demethylation (GO:0070989)3.48434494
54resolution of meiotic recombination intermediates (GO:0000712)3.44767913
55proteasome assembly (GO:0043248)3.44172572
56histone H4-K12 acetylation (GO:0043983)3.42930564
57DNA replication-independent nucleosome organization (GO:0034724)3.42895310
58DNA replication-independent nucleosome assembly (GO:0006336)3.42895310
59negative regulation of JAK-STAT cascade (GO:0046426)3.41080011
60mitotic recombination (GO:0006312)3.40989818
61phospholipid scrambling (GO:0017121)3.39651912
62regulation of double-strand break repair (GO:2000779)3.37193449
63regulation of protein homooligomerization (GO:0032462)3.35878868
64chaperone-mediated protein transport (GO:0072321)3.34484250
65mitochondrial DNA metabolic process (GO:0032042)3.34248592
66regulation of integrin activation (GO:0033623)3.32556696
67positive regulation of DNA repair (GO:0045739)3.31581576
68telomere maintenance via telomere lengthening (GO:0010833)3.31440871
69regulation of DNA damage checkpoint (GO:2000001)3.29897208
70dosage compensation (GO:0007549)3.29581924
71mitotic sister chromatid segregation (GO:0000070)3.27424788
72mitotic metaphase plate congression (GO:0007080)3.25817782
73cullin deneddylation (GO:0010388)3.25737757
74single strand break repair (GO:0000012)3.25204629
75regulation of sister chromatid cohesion (GO:0007063)3.25116451
76mRNA export from nucleus (GO:0006406)3.21970810
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18790743
78DNA catabolic process, exonucleolytic (GO:0000738)3.18216357
79DNA demethylation (GO:0080111)3.18203789
80purine nucleobase biosynthetic process (GO:0009113)3.18143035
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16105446
82regulation of mitochondrial translation (GO:0070129)3.14300860
83metaphase plate congression (GO:0051310)3.14172530
84double-strand break repair via nonhomologous end joining (GO:0006303)3.13554823
85non-recombinational repair (GO:0000726)3.13554823
86rRNA modification (GO:0000154)3.12099417
87histone H2A acetylation (GO:0043968)3.10298073
88negative regulation of mRNA metabolic process (GO:1903312)3.10252301
89spliceosomal snRNP assembly (GO:0000387)3.08554342
90RNA export from nucleus (GO:0006405)3.08050544
91regulation of cAMP-dependent protein kinase activity (GO:2000479)3.07504759
92histone arginine methylation (GO:0034969)3.05940946
93ATP synthesis coupled proton transport (GO:0015986)3.02683302
94energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02683302
95mitochondrial respiratory chain complex assembly (GO:0033108)3.01818413
96negative regulation of cell cycle arrest (GO:0071157)3.00297220
97establishment of viral latency (GO:0019043)2.99999213
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.99981308
99NADH dehydrogenase complex assembly (GO:0010257)2.99981308
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99981308
101IMP biosynthetic process (GO:0006188)2.99376597
102base-excision repair, AP site formation (GO:0006285)2.96727720
103protein complex biogenesis (GO:0070271)2.95911650
104negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95651832
105mRNA transport (GO:0051028)2.95279536
106negative regulation of chromosome segregation (GO:0051985)2.95272041
107synapsis (GO:0007129)2.94857497
108DNA replication initiation (GO:0006270)2.93153172
109negative regulation of DNA recombination (GO:0045910)2.93126892
110rRNA methylation (GO:0031167)2.91953507
111mitotic G1 DNA damage checkpoint (GO:0031571)2.91069004
112mitochondrial RNA metabolic process (GO:0000959)2.90963646
113protein localization to chromosome, centromeric region (GO:0071459)2.90591012
114ribosome biogenesis (GO:0042254)2.89596420
115nucleobase biosynthetic process (GO:0046112)2.89388510
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89330977
117pseudouridine synthesis (GO:0001522)2.88393585
118ribosomal large subunit biogenesis (GO:0042273)2.88331432
119histone mRNA metabolic process (GO:0008334)2.86547872
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86272933
121regulation of DNA repair (GO:0006282)2.85646909
122regulation of gene silencing by RNA (GO:0060966)2.85273822
123regulation of posttranscriptional gene silencing (GO:0060147)2.85273822
124regulation of gene silencing by miRNA (GO:0060964)2.85273822
125sister chromatid segregation (GO:0000819)2.85143508
126protein deneddylation (GO:0000338)2.84994897
127regulation of centriole replication (GO:0046599)2.84591504
128peptidyl-arginine omega-N-methylation (GO:0035247)2.83884111
129regulation of mitotic spindle checkpoint (GO:1903504)2.83522759
130regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83522759
131termination of RNA polymerase III transcription (GO:0006386)2.83210330
132transcription elongation from RNA polymerase III promoter (GO:0006385)2.83210330
133protein localization to kinetochore (GO:0034501)2.82492964
134regulation of RNA export from nucleus (GO:0046831)2.81122126
135mismatch repair (GO:0006298)2.80711826
136regulation of translational fidelity (GO:0006450)2.80699596
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.79101941
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77727471
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77569579
140mitotic spindle checkpoint (GO:0071174)2.77119328
141spindle checkpoint (GO:0031577)2.75664209
142regulation of cilium movement (GO:0003352)2.73873735
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73830537
144negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73775574
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73775574
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73775574
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.73775574
148negative regulation of sister chromatid segregation (GO:0033046)2.73775574
149G1 DNA damage checkpoint (GO:0044783)2.73524347
150* mRNA cleavage (GO:0006379)2.72725218
151* RNA splicing, via transesterification reactions (GO:0000375)2.72484278
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.72270756
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72197369
154somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72197369
155isotype switching (GO:0045190)2.72197369
156respiratory chain complex IV assembly (GO:0008535)2.72130724
157motile cilium assembly (GO:0044458)2.71842618
158histone H4-K5 acetylation (GO:0043981)2.71713398
159histone H4-K8 acetylation (GO:0043982)2.71713398
160nuclear pore organization (GO:0006999)2.71372977
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69318248
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69318248
163oxidative phosphorylation (GO:0006119)2.67314350
164spindle assembly checkpoint (GO:0071173)2.63188905
165negative regulation of ligase activity (GO:0051352)2.62377279
166negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62377279
167mitotic spindle assembly checkpoint (GO:0007094)2.62191490
168intraciliary transport (GO:0042073)2.60685293
169postreplication repair (GO:0006301)2.60658222
170mitotic sister chromatid cohesion (GO:0007064)2.59582622
171ribosome assembly (GO:0042255)2.59198233
172ATP-dependent chromatin remodeling (GO:0043044)2.58852221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.98856824
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.18143016
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41738117
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.35923995
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.98372288
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83561788
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82861903
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74271893
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71533304
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67160521
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62907075
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57888706
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55710169
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51201475
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51201475
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51201475
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.36908183
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33805214
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33129537
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.30585105
21IGF1R_20145208_ChIP-Seq_DFB_Human2.24919710
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24606370
23ZNF274_21170338_ChIP-Seq_K562_Hela2.22942221
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22719572
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18092827
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16561286
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15973586
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13769531
29* GABP_17652178_ChIP-ChIP_JURKAT_Human2.13129228
30FUS_26573619_Chip-Seq_HEK293_Human2.09134345
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03220916
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.02970845
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00542488
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00471934
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.99049689
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96261031
37TTF2_22483619_ChIP-Seq_HELA_Human1.95109619
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93583541
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.92639822
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90619558
41* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.87067151
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.83668259
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.81681789
44* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81535323
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80318754
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.79578068
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77645887
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75974601
49DCP1A_22483619_ChIP-Seq_HELA_Human1.75918033
50* GABP_19822575_ChIP-Seq_HepG2_Human1.75783591
51* MYC_18940864_ChIP-ChIP_HL60_Human1.75017218
52* VDR_23849224_ChIP-Seq_CD4+_Human1.74906148
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73280821
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69291268
55VDR_22108803_ChIP-Seq_LS180_Human1.68141589
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67143650
57TAF15_26573619_Chip-Seq_HEK293_Human1.66897582
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66648382
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65750637
60XRN2_22483619_ChIP-Seq_HELA_Human1.64610907
61NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.64208007
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62565838
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60540147
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57494031
65* ELK1_19687146_ChIP-ChIP_HELA_Human1.56409286
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55736212
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52816285
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52010626
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51202492
70FOXP3_21729870_ChIP-Seq_TREG_Human1.48657439
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46443324
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44950237
73AR_21909140_ChIP-Seq_LNCAP_Human1.44833823
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42379550
75* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40164638
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.40050387
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38982946
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36090797
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.35624365
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34409617
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33274550
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31494846
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28299892
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.27642534
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27377484
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26617298
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26279448
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25161545
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22834915
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21823733
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.19838335
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19654775
93KDM5A_27292631_Chip-Seq_BREAST_Human1.18831942
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18411478
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.17956803
96P300_19829295_ChIP-Seq_ESCs_Human1.17056614
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15941870
98* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15444799
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15419369
100* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15002091
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14705179
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14329033
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12275293
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09407756
105IRF1_19129219_ChIP-ChIP_H3396_Human1.08712996
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05713589
107EWS_26573619_Chip-Seq_HEK293_Human1.03969731
108* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03848179
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02825766
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01901966
111TFEB_21752829_ChIP-Seq_HELA_Human1.00897432
112* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00649971
113* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99844466
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98730823
115* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98350776
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98266505
117* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97011919
118* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96978792
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96483396
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96147106
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96089091
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96018997
123HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95646105
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95234091
125* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95122680
126RNF2_27304074_Chip-Seq_NSC_Mouse0.94962491
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94885151
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93595269
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92812500
130* NANOG_16518401_ChIP-PET_MESCs_Mouse0.91901393
131* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91692426
132PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90329781
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90113774
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88194600
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87845075
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.85410056
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84235011
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83964616
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82698852
140CBP_20019798_ChIP-Seq_JUKART_Human0.82698852
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82677918
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81909629
143GBX2_23144817_ChIP-Seq_PC3_Human0.81037745
144TP53_22573176_ChIP-Seq_HFKS_Human0.80843778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.68161522
2MP0005171_absent_coat_pigmentation3.67118722
3MP0010094_abnormal_chromosome_stability3.55633677
4MP0008877_abnormal_DNA_methylation3.52076842
5MP0008058_abnormal_DNA_repair3.24265047
6MP0004957_abnormal_blastocyst_morpholog2.88359183
7MP0003890_abnormal_embryonic-extraembry2.79547069
8MP0003693_abnormal_embryo_hatching2.78987059
9MP0010030_abnormal_orbit_morphology2.73486839
10MP0003111_abnormal_nucleus_morphology2.71038356
11MP0006292_abnormal_olfactory_placode2.69312431
12MP0003786_premature_aging2.65066813
13MP0003077_abnormal_cell_cycle2.30184670
14MP0001529_abnormal_vocalization2.18937137
15MP0006072_abnormal_retinal_apoptosis2.03764692
16MP0008995_early_reproductive_senescence1.99986398
17MP0002009_preneoplasia1.96418039
18MP0004233_abnormal_muscle_weight1.95906515
19MP0008932_abnormal_embryonic_tissue1.95464026
20MP0003718_maternal_effect1.94788378
21MP0009278_abnormal_bone_marrow1.93765979
22MP0004133_heterotaxia1.93676350
23MP0002102_abnormal_ear_morphology1.84797113
24MP0003119_abnormal_digestive_system1.82741861
25MP0003937_abnormal_limbs/digits/tail_de1.66443118
26MP0000015_abnormal_ear_pigmentation1.63100427
27MP0001293_anophthalmia1.59187097
28MP0002234_abnormal_pharynx_morphology1.58101895
29MP0008007_abnormal_cellular_replicative1.55095927
30MP0005174_abnormal_tail_pigmentation1.53644581
31MP0002084_abnormal_developmental_patter1.52257585
32MP0000350_abnormal_cell_proliferation1.47616570
33MP0003121_genomic_imprinting1.47290786
34MP0002233_abnormal_nose_morphology1.45810022
35MP0003123_paternal_imprinting1.45428297
36MP0002085_abnormal_embryonic_tissue1.43542438
37MP0003941_abnormal_skin_development1.42336535
38MP0001697_abnormal_embryo_size1.38334664
39MP0002653_abnormal_ependyma_morphology1.37525184
40MP0000371_diluted_coat_color1.37486758
41MP0001984_abnormal_olfaction1.36635194
42MP0002160_abnormal_reproductive_system1.36259851
43MP0002086_abnormal_extraembryonic_tissu1.35045759
44MP0005084_abnormal_gallbladder_morpholo1.32569408
45MP0003880_abnormal_central_pattern1.29160210
46MP0001186_pigmentation_phenotype1.27617276
47MP0003787_abnormal_imprinting1.25758587
48MP0006276_abnormal_autonomic_nervous1.25339681
49MP0002163_abnormal_gland_morphology1.25025085
50MP0004197_abnormal_fetal_growth/weight/1.24679258
51MP0005380_embryogenesis_phenotype1.23843024
52MP0001672_abnormal_embryogenesis/_devel1.23843024
53MP0000631_abnormal_neuroendocrine_gland1.22593986
54MP0002249_abnormal_larynx_morphology1.21493147
55MP0006035_abnormal_mitochondrial_morpho1.20820019
56MP0001730_embryonic_growth_arrest1.19933588
57MP0000049_abnormal_middle_ear1.18575921
58MP0002075_abnormal_coat/hair_pigmentati1.17315493
59MP0003283_abnormal_digestive_organ1.15241127
60MP0000537_abnormal_urethra_morphology1.15103552
61MP0000372_irregular_coat_pigmentation1.14861505
62MP0001348_abnormal_lacrimal_gland1.13192103
63MP0005645_abnormal_hypothalamus_physiol1.13170794
64MP0002210_abnormal_sex_determination1.11394068
65MP0000490_abnormal_crypts_of1.10548130
66MP0000647_abnormal_sebaceous_gland1.10294170
67MP0002282_abnormal_trachea_morphology1.09648993
68MP0003315_abnormal_perineum_morphology1.09220294
69MP0002697_abnormal_eye_size1.07220275
70MP0005397_hematopoietic_system_phenotyp1.06753173
71MP0001545_abnormal_hematopoietic_system1.06753173
72MP0002751_abnormal_autonomic_nervous1.06537956
73MP0002736_abnormal_nociception_after1.06315895
74MP0003567_abnormal_fetal_cardiomyocyte1.06222851
75MP0001764_abnormal_homeostasis1.06201835
76MP0003755_abnormal_palate_morphology1.05707744
77MP0000566_synostosis1.05437289
78MP0001145_abnormal_male_reproductive1.04643230
79MP0005187_abnormal_penis_morphology1.04524841
80MP0005551_abnormal_eye_electrophysiolog0.99601733
81MP0005391_vision/eye_phenotype0.98835572
82MP0005646_abnormal_pituitary_gland0.98270080
83MP0003698_abnormal_male_reproductive0.98230971
84MP0005076_abnormal_cell_differentiation0.98179360
85MP0002111_abnormal_tail_morphology0.97692094
86MP0002080_prenatal_lethality0.96945500
87MP0000516_abnormal_urinary_system0.96472158
88MP0005367_renal/urinary_system_phenotyp0.96472158
89MP0003984_embryonic_growth_retardation0.96393366
90MP0000313_abnormal_cell_death0.95853496
91MP0002938_white_spotting0.94908732
92MP0003186_abnormal_redox_activity0.93593365
93MP0008789_abnormal_olfactory_epithelium0.93392129
94MP0001188_hyperpigmentation0.93301292
95MP0005075_abnormal_melanosome_morpholog0.93154681
96MP0003122_maternal_imprinting0.92268851
97MP0002088_abnormal_embryonic_growth/wei0.91215157
98MP0002332_abnormal_exercise_endurance0.89596064
99MP0002116_abnormal_craniofacial_bone0.88688542
100MP0002114_abnormal_axial_skeleton0.87412167
101MP0003935_abnormal_craniofacial_develop0.87398801
102MP0009697_abnormal_copulation0.85549509
103MP0010352_gastrointestinal_tract_polyps0.84833357
104MP0000653_abnormal_sex_gland0.83750153
105MP0002019_abnormal_tumor_incidence0.83536695
106MP0005248_abnormal_Harderian_gland0.82680994
107MP0001929_abnormal_gametogenesis0.82574676
108MP0002752_abnormal_somatic_nervous0.82408341
109MP0003136_yellow_coat_color0.81961462
110MP0002396_abnormal_hematopoietic_system0.81770343
111MP0001346_abnormal_lacrimal_gland0.81474221
112MP0005394_taste/olfaction_phenotype0.80645645
113MP0005499_abnormal_olfactory_system0.80645645
114MP0009703_decreased_birth_body0.80290292
115MP0002184_abnormal_innervation0.79533627
116MP0003861_abnormal_nervous_system0.79337290
117MP0005195_abnormal_posterior_eye0.77670876
118MP0006036_abnormal_mitochondrial_physio0.77573645
119MP0000569_abnormal_digit_pigmentation0.77497403
120MP0001119_abnormal_female_reproductive0.77070858
121MP0003938_abnormal_ear_development0.76845672
122MP0000358_abnormal_cell_content/0.76806240
123MP0000470_abnormal_stomach_morphology0.75684625
124MP0002932_abnormal_joint_morphology0.75384787
125MP0002638_abnormal_pupillary_reflex0.75035233
126MP0001919_abnormal_reproductive_system0.74464929
127MP0001177_atelectasis0.73111937
128MP0005253_abnormal_eye_physiology0.72922021
129MP0001286_abnormal_eye_development0.72283259
130MP0000432_abnormal_head_morphology0.72270234
131MP0000778_abnormal_nervous_system0.69376066
132MP0005266_abnormal_metabolism0.68289578
133MP0000762_abnormal_tongue_morphology0.67021903
134MP0005389_reproductive_system_phenotype0.64954265
135MP0002132_abnormal_respiratory_system0.64445577
136MP0003385_abnormal_body_wall0.63783255
137MP0003453_abnormal_keratinocyte_physiol0.63192793
138MP0003943_abnormal_hepatobiliary_system0.62892484
139MP0000678_abnormal_parathyroid_gland0.62151873

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)4.24738741
2Rib fusion (HP:0000902)4.19255455
3Volvulus (HP:0002580)4.06438457
4Rectal fistula (HP:0100590)3.88008733
5Rectovaginal fistula (HP:0000143)3.88008733
6Intestinal atresia (HP:0011100)3.72071369
7Intestinal fistula (HP:0100819)3.61500830
8Increased IgM level (HP:0003496)3.54871211
9Patellar aplasia (HP:0006443)3.44354013
10Abnormality of the labia minora (HP:0012880)3.40827659
11Annular pancreas (HP:0001734)3.37656761
12Abnormal respiratory epithelium morphology (HP:0012253)3.33005047
13Abnormal respiratory motile cilium morphology (HP:0005938)3.33005047
14Absent radius (HP:0003974)3.23442811
15Aplasia/Hypoplasia of the patella (HP:0006498)3.12342786
16Vaginal fistula (HP:0004320)3.12136762
17Increased hepatocellular lipid droplets (HP:0006565)3.10266048
18Absent forearm bone (HP:0003953)3.05720034
19Aplasia involving forearm bones (HP:0009822)3.05720034
20Colon cancer (HP:0003003)3.03450096
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01990650
22Acute necrotizing encephalopathy (HP:0006965)2.94813256
23Concave nail (HP:0001598)2.91875819
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.91575970
25Absent/shortened dynein arms (HP:0200106)2.91575970
26Orthostatic hypotension (HP:0001278)2.85392094
27Absent thumb (HP:0009777)2.84394325
28Short humerus (HP:0005792)2.84114221
29Aplasia/hypoplasia of the humerus (HP:0006507)2.83323670
30Lipid accumulation in hepatocytes (HP:0006561)2.81168795
31Increased CSF lactate (HP:0002490)2.80917337
32Hypochromic microcytic anemia (HP:0004840)2.77902152
33Mitochondrial inheritance (HP:0001427)2.74395824
34Breast hypoplasia (HP:0003187)2.71426758
35Chromsome breakage (HP:0040012)2.70553106
36Acute encephalopathy (HP:0006846)2.70316494
37Tongue fasciculations (HP:0001308)2.68592674
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68279065
39Median cleft lip (HP:0000161)2.64914413
40Pancreatic fibrosis (HP:0100732)2.63780944
41Abnormality of the ileum (HP:0001549)2.63285442
42Abnormal mitochondria in muscle tissue (HP:0008316)2.62298462
43Birth length less than 3rd percentile (HP:0003561)2.59270755
44Premature graying of hair (HP:0002216)2.58558524
45Capillary hemangiomas (HP:0005306)2.57075184
46Abnormal number of incisors (HP:0011064)2.56381533
47Abnormality of male internal genitalia (HP:0000022)2.55314858
48Nephronophthisis (HP:0000090)2.54493116
49Supernumerary spleens (HP:0009799)2.53876792
50Poikiloderma (HP:0001029)2.53781834
51Hepatocellular necrosis (HP:0001404)2.52996860
52Selective tooth agenesis (HP:0001592)2.51755221
53True hermaphroditism (HP:0010459)2.49078300
54Increased number of teeth (HP:0011069)2.45894273
55Medial flaring of the eyebrow (HP:0010747)2.44527702
56Abnormal lung lobation (HP:0002101)2.42142680
57Abnormality of midbrain morphology (HP:0002418)2.41464087
58Molar tooth sign on MRI (HP:0002419)2.41464087
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40349808
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40349808
61Progressive macrocephaly (HP:0004481)2.38410159
62Hyperglycinemia (HP:0002154)2.37448758
63Pancreatic cysts (HP:0001737)2.36441549
64Hepatic necrosis (HP:0002605)2.35760790
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33843242
66Abnormality of alanine metabolism (HP:0010916)2.33843242
67Hyperalaninemia (HP:0003348)2.33843242
68Shawl scrotum (HP:0000049)2.26356628
69Ependymoma (HP:0002888)2.26132181
70Congenital primary aphakia (HP:0007707)2.25737944
71Spinal muscular atrophy (HP:0007269)2.24962726
72Broad alveolar ridges (HP:0000187)2.21843351
73Muscle fibrillation (HP:0010546)2.20839798
74Gait imbalance (HP:0002141)2.20747839
75Nephrogenic diabetes insipidus (HP:0009806)2.20575939
76Abnormality of the aortic arch (HP:0012303)2.20528496
77Basal cell carcinoma (HP:0002671)2.20131257
78Methylmalonic acidemia (HP:0002912)2.19988030
79Nephroblastoma (Wilms tumor) (HP:0002667)2.19411530
80Increased serum lactate (HP:0002151)2.18479407
81Acute lymphatic leukemia (HP:0006721)2.18153703
82Renal Fanconi syndrome (HP:0001994)2.17868002
83Dysautonomia (HP:0002459)2.15969770
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.14246932
85Genital tract atresia (HP:0001827)2.13671093
86Abnormality of the preputium (HP:0100587)2.13326556
87Embryonal renal neoplasm (HP:0011794)2.13010695
88Neoplasm of the oral cavity (HP:0100649)2.11672037
89Hypoplasia of the radius (HP:0002984)2.10858975
90Alopecia of scalp (HP:0002293)2.10689275
91Increased serum pyruvate (HP:0003542)2.08452839
92Hypoplastic pelvis (HP:0008839)2.08313578
93Febrile seizures (HP:0002373)2.08241841
94Medulloblastoma (HP:0002885)2.08107588
95Cerebral edema (HP:0002181)2.07790474
963-Methylglutaconic aciduria (HP:0003535)2.05974269
97Tubulointerstitial nephritis (HP:0001970)2.04120661
98Rhabdomyosarcoma (HP:0002859)2.03221932
99Pustule (HP:0200039)2.02658502
100Vaginal atresia (HP:0000148)2.01870745
101Abnormality of the renal medulla (HP:0100957)2.01441815
102Cortical dysplasia (HP:0002539)2.01105139
103Triphalangeal thumb (HP:0001199)2.00577842
104Abnormality of glycine metabolism (HP:0010895)2.00010179
105Abnormality of serine family amino acid metabolism (HP:0010894)2.00010179
106Gastrointestinal atresia (HP:0002589)1.99680383
107Hyperglycinuria (HP:0003108)1.99368371
108Duodenal stenosis (HP:0100867)1.98491884
109Small intestinal stenosis (HP:0012848)1.98491884
110Short chin (HP:0000331)1.98144897
111Short thumb (HP:0009778)1.96801139
112Abnormality of serum amino acid levels (HP:0003112)1.96606865
113Meckel diverticulum (HP:0002245)1.96440238
114Albinism (HP:0001022)1.96430961
115Small hand (HP:0200055)1.96248024
116Alacrima (HP:0000522)1.95165948
117Preaxial hand polydactyly (HP:0001177)1.93783558
118Bifid uvula (HP:0000193)1.93157081
119Type I transferrin isoform profile (HP:0003642)1.92909303
120Squamous cell carcinoma (HP:0002860)1.92607076
121Decreased testicular size (HP:0008734)1.92548771
122Abnormality of glycolysis (HP:0004366)1.91493106
123Lactic acidosis (HP:0003128)1.90189764
124Abnormality of chromosome stability (HP:0003220)1.88700833
125Anteriorly placed anus (HP:0001545)1.88666872
126IgA deficiency (HP:0002720)1.87958517
127Congenital hip dislocation (HP:0001374)1.87777147
128Myelodysplasia (HP:0002863)1.87587919
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.86970398
130Abnormality of abdominal situs (HP:0011620)1.86641547
131Abdominal situs inversus (HP:0003363)1.86641547
132Short tibia (HP:0005736)1.86450622
133Abnormal hemoglobin (HP:0011902)1.86400334
134Type 2 muscle fiber atrophy (HP:0003554)1.86182378
135Abnormality of the duodenum (HP:0002246)1.86148828
136Amelogenesis imperfecta (HP:0000705)1.84903173
137Sloping forehead (HP:0000340)1.84126055
138Abnormality of methionine metabolism (HP:0010901)1.82632754
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.82575490
140Abnormality of the anterior horn cell (HP:0006802)1.81860144
141Degeneration of anterior horn cells (HP:0002398)1.81860144
142Agnosia (HP:0010524)1.81760503
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81120621
144Abnormal protein N-linked glycosylation (HP:0012347)1.81120621
145Abnormal protein glycosylation (HP:0012346)1.81120621
146Abnormal glycosylation (HP:0012345)1.81120621
147Anophthalmia (HP:0000528)1.80478426
148Abnormality of the astrocytes (HP:0100707)1.79331135
149Astrocytoma (HP:0009592)1.79331135
150Sclerocornea (HP:0000647)1.79238595
151Male infertility (HP:0003251)1.77640784
152Oligodactyly (hands) (HP:0001180)1.77204994
153Vertebral hypoplasia (HP:0008417)1.76853717
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76853717
155Postnatal microcephaly (HP:0005484)1.76195579
156Glioma (HP:0009733)1.75409953
157Hypoplasia of the ulna (HP:0003022)1.75040338
158Hypotelorism (HP:0000601)1.74251478
159Ectopic anus (HP:0004397)1.73966143
160Hemivertebrae (HP:0002937)1.73610693
161Poor coordination (HP:0002370)1.73527374
162Aplasia of the musculature (HP:0100854)1.71959386
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.71662939
164Reticulocytopenia (HP:0001896)1.71308634
165Facial cleft (HP:0002006)1.70012606
166Postaxial foot polydactyly (HP:0001830)1.69323452
167Postaxial hand polydactyly (HP:0001162)1.68117289
168Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67120641
169Pendular nystagmus (HP:0012043)1.66782194
170Broad foot (HP:0001769)1.65254769
171Increased intramyocellular lipid droplets (HP:0012240)1.64559898
172Methylmalonic aciduria (HP:0012120)1.64222029
173Stenosis of the external auditory canal (HP:0000402)1.62429931
174Aplastic anemia (HP:0001915)1.62006164
175Bifid tongue (HP:0010297)1.60214265
176Oligodactyly (HP:0012165)1.59068687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K63.76160265
2DDR23.39192722
3ICK3.34366904
4MAPK153.31211702
5VRK22.73080097
6DAPK12.70656452
7YES12.57012713
8CDC72.47699080
9PINK12.40170606
10TRIM282.36632772
11NUAK12.34483256
12PBK2.33317025
13WNK32.31452817
14MAP4K22.24900301
15AKT32.18132939
16MAP3K112.14527694
17MKNK22.11482905
18MATK2.05048857
19FGR2.00541928
20CDK71.99989308
21BCR1.88534619
22BMPR1B1.84811619
23UHMK11.77385505
24MKNK11.75313871
25WEE11.71731797
26ERBB31.70828820
27PLK11.68232462
28PIM11.65571387
29CHEK21.61980250
30SRPK11.61069614
31ATR1.60204680
32MST41.59436741
33MAP3K41.57052317
34TAF11.55480620
35DYRK31.52469924
36EIF2AK31.47277093
37TYRO31.44655262
38PIM21.44237341
39NME11.40919765
40BUB11.39627513
41CDK121.38588439
42ACVR1B1.34594751
43CDK191.33112432
44CSNK1G11.32952218
45PRKD21.30214989
46EIF2AK11.28793762
47TNIK1.27883555
48CSNK1G31.21937519
49STK161.21181484
50MAP3K101.18442708
51TTK1.18211565
52MAP3K121.17943839
53CDK61.17572412
54TAOK21.17469638
55PLK41.17283964
56CSNK1G21.16933343
57EPHA21.15994138
58PNCK1.14208485
59DYRK1B1.12182723
60FRK1.12121213
61BCKDK1.11316090
62STK38L1.08957406
63CSNK1A1L1.06380587
64BRSK11.05943340
65PDGFRA1.05730810
66MARK11.03739965
67LATS21.03544348
68PDK20.99677893
69CDC42BPA0.99562190
70AURKB0.98529537
71CSK0.94750516
72ATM0.92571276
73PLK30.91226378
74CHEK10.91000349
75PRPF4B0.88270824
76RPS6KL10.85741048
77RPS6KC10.85741048
78CDK20.84230440
79CCNB10.83104127
80CDK80.81979490
81AURKA0.81755106
82ZAK0.81528222
83BMX0.80140977
84RPS6KB20.77329768
85NEK20.75257753
86MUSK0.75165456
87RPS6KA60.75095677
88BRD40.74444925
89TRPM70.73373916
90CSNK2A10.70383052
91CDK30.69864160
92MAPK130.68199728
93MINK10.65755951
94CHUK0.65499803
95CSNK1E0.65287529
96TSSK60.64955146
97ADRBK20.64280980
98RPS6KB10.64276697
99VRK10.64249888
100TGFBR10.63781357
101GRK10.60712179
102CDK40.60477087
103ERBB40.60260310
104RPS6KA40.59832311
105TLK10.59232142
106WNK40.58598111
107PRKCG0.58583483
108MAPKAPK50.57761289
109CDK10.57167449
110RPS6KA50.56656046
111CSNK2A20.56442391
112PLK20.56086717
113STK390.53088275
114FLT30.51544043
115STK40.51137652
116DYRK20.50944131
117MAPK140.49433332
118BRSK20.46289372
119GSK3A0.46093529
120CASK0.46047705
121MAP2K70.45862093
122OXSR10.45673199
123NEK10.45661483
124SIK30.45056007
125RPS6KA10.42956901
126LYN0.42137244
127PAK30.41483643
128PRKCI0.41464653
129PRKDC0.38947572
130PRKCE0.38774587
131FGFR10.37716365
132LATS10.36164588
133HIPK20.35769129
134MAPK100.35486423
135CSNK1A10.35011752
136PASK0.34807109
137STK30.34268866
138NME20.34195294
139EIF2AK20.34097705
140AKT10.32433027
141PHKG10.32184800
142PHKG20.32184800
143SGK10.32057765
144CLK10.31670658
145STK240.31529925
146CSNK1D0.30714369
147INSRR0.29582967
148SCYL20.28460410
149CDK140.27814486
150PRKACB0.27809104

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.99996245
2DNA replication_Homo sapiens_hsa030304.30585856
3Base excision repair_Homo sapiens_hsa034103.83623402
4Protein export_Homo sapiens_hsa030603.39540288
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28721979
6Spliceosome_Homo sapiens_hsa030403.26114780
7Homologous recombination_Homo sapiens_hsa034403.00587208
8RNA transport_Homo sapiens_hsa030132.77374131
9Fanconi anemia pathway_Homo sapiens_hsa034602.58874083
10Nucleotide excision repair_Homo sapiens_hsa034202.53880614
11Oxidative phosphorylation_Homo sapiens_hsa001902.42318196
12Cell cycle_Homo sapiens_hsa041102.32334796
13RNA polymerase_Homo sapiens_hsa030202.31879289
14Parkinsons disease_Homo sapiens_hsa050122.20966542
15* mRNA surveillance pathway_Homo sapiens_hsa030152.13575897
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.12726147
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94439467
18Fatty acid biosynthesis_Homo sapiens_hsa000611.93907223
19Proteasome_Homo sapiens_hsa030501.85400264
20Basal transcription factors_Homo sapiens_hsa030221.83462812
21Propanoate metabolism_Homo sapiens_hsa006401.79741594
22Steroid biosynthesis_Homo sapiens_hsa001001.79685990
23p53 signaling pathway_Homo sapiens_hsa041151.65985100
24RNA degradation_Homo sapiens_hsa030181.65150760
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57877647
26Circadian rhythm_Homo sapiens_hsa047101.54101508
27Ribosome_Homo sapiens_hsa030101.42903427
28Pyrimidine metabolism_Homo sapiens_hsa002401.42276706
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41075127
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.36899553
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35817128
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34983906
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32477679
34Pyruvate metabolism_Homo sapiens_hsa006201.31663415
35Non-homologous end-joining_Homo sapiens_hsa034501.30174455
36Oocyte meiosis_Homo sapiens_hsa041141.28492012
37Allograft rejection_Homo sapiens_hsa053301.28177352
38Alzheimers disease_Homo sapiens_hsa050101.21805418
39Fatty acid elongation_Homo sapiens_hsa000621.20590188
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18032601
41Asthma_Homo sapiens_hsa053101.11472612
42Hippo signaling pathway_Homo sapiens_hsa043901.08670850
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07125397
44Hedgehog signaling pathway_Homo sapiens_hsa043401.02813736
45Folate biosynthesis_Homo sapiens_hsa007901.00638866
46Selenocompound metabolism_Homo sapiens_hsa004501.00545216
47Butanoate metabolism_Homo sapiens_hsa006500.99309416
48Autoimmune thyroid disease_Homo sapiens_hsa053200.96324915
49One carbon pool by folate_Homo sapiens_hsa006700.96087580
50Notch signaling pathway_Homo sapiens_hsa043300.95895239
51Primary immunodeficiency_Homo sapiens_hsa053400.93604743
52Wnt signaling pathway_Homo sapiens_hsa043100.93600180
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92191006
54Epstein-Barr virus infection_Homo sapiens_hsa051690.91768028
55Nicotine addiction_Homo sapiens_hsa050330.87612033
56Vitamin B6 metabolism_Homo sapiens_hsa007500.86732350
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85760746
58TGF-beta signaling pathway_Homo sapiens_hsa043500.85497147
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.84870320
60Adherens junction_Homo sapiens_hsa045200.84589975
61Herpes simplex infection_Homo sapiens_hsa051680.84315758
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84147761
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84079324
64Purine metabolism_Homo sapiens_hsa002300.83189498
65Basal cell carcinoma_Homo sapiens_hsa052170.82993165
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82495611
67Legionellosis_Homo sapiens_hsa051340.80499362
68Glutathione metabolism_Homo sapiens_hsa004800.80127611
69Peroxisome_Homo sapiens_hsa041460.79165701
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78815702
71Colorectal cancer_Homo sapiens_hsa052100.78547682
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78028169
73mTOR signaling pathway_Homo sapiens_hsa041500.76485959
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74865362
75Metabolic pathways_Homo sapiens_hsa011000.72345106
76MicroRNAs in cancer_Homo sapiens_hsa052060.71951045
77Fatty acid metabolism_Homo sapiens_hsa012120.70104567
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67905717
79Cardiac muscle contraction_Homo sapiens_hsa042600.67620748
80Caffeine metabolism_Homo sapiens_hsa002320.67503800
81HTLV-I infection_Homo sapiens_hsa051660.66094776
82Shigellosis_Homo sapiens_hsa051310.65955096
83Carbon metabolism_Homo sapiens_hsa012000.64182834
84Phototransduction_Homo sapiens_hsa047440.60419509
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59449805
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58021550
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57924845
88Type I diabetes mellitus_Homo sapiens_hsa049400.57616391
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56373072
90Viral carcinogenesis_Homo sapiens_hsa052030.56029943
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56021730
92Systemic lupus erythematosus_Homo sapiens_hsa053220.52573499
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52444620
94Sulfur metabolism_Homo sapiens_hsa009200.51895896
95Arginine and proline metabolism_Homo sapiens_hsa003300.51469316
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49599245
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48328748
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45077572
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44915534
100Huntingtons disease_Homo sapiens_hsa050160.44723761
101Regulation of autophagy_Homo sapiens_hsa041400.44400225
102Tryptophan metabolism_Homo sapiens_hsa003800.43805313
103Sulfur relay system_Homo sapiens_hsa041220.42538919
104Olfactory transduction_Homo sapiens_hsa047400.38695799
105Measles_Homo sapiens_hsa051620.38548367
106Graft-versus-host disease_Homo sapiens_hsa053320.38308758
107N-Glycan biosynthesis_Homo sapiens_hsa005100.38089215
108Amphetamine addiction_Homo sapiens_hsa050310.36905509
109beta-Alanine metabolism_Homo sapiens_hsa004100.35294091
110Retinol metabolism_Homo sapiens_hsa008300.33632315
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33241333
112Linoleic acid metabolism_Homo sapiens_hsa005910.32403489
113Viral myocarditis_Homo sapiens_hsa054160.31591222
114Hepatitis B_Homo sapiens_hsa051610.30998681
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.30960970
116Collecting duct acid secretion_Homo sapiens_hsa049660.30168669
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29729089
118MAPK signaling pathway_Homo sapiens_hsa040100.29575177
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29419054
120Small cell lung cancer_Homo sapiens_hsa052220.28579212
121Taste transduction_Homo sapiens_hsa047420.27933297
122Fatty acid degradation_Homo sapiens_hsa000710.27718746
123Biosynthesis of amino acids_Homo sapiens_hsa012300.27658062
124Nitrogen metabolism_Homo sapiens_hsa009100.27308173
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27089584
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26774615
127Alcoholism_Homo sapiens_hsa050340.26204671
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25141272
129Lysine degradation_Homo sapiens_hsa003100.25101708
130Bladder cancer_Homo sapiens_hsa052190.24593571
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24438432
132Pathways in cancer_Homo sapiens_hsa052000.23515689
133Ether lipid metabolism_Homo sapiens_hsa005650.23451171
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23119944
135Choline metabolism in cancer_Homo sapiens_hsa052310.22490839
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.22162817
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.22048444
138Insulin signaling pathway_Homo sapiens_hsa049100.22001960
139Dopaminergic synapse_Homo sapiens_hsa047280.20702645
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20512940
141Gap junction_Homo sapiens_hsa045400.20339049
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19882790
143ErbB signaling pathway_Homo sapiens_hsa040120.19190253
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18481216
145Serotonergic synapse_Homo sapiens_hsa047260.17235514
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16903131
147Antigen processing and presentation_Homo sapiens_hsa046120.16510412
148Prostate cancer_Homo sapiens_hsa052150.15584652
149Melanoma_Homo sapiens_hsa052180.15577819
150Thyroid cancer_Homo sapiens_hsa052160.15449796
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14695625
152Morphine addiction_Homo sapiens_hsa050320.14139260
153VEGF signaling pathway_Homo sapiens_hsa043700.13687956
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13487524

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