ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gonadal mesoderm development (GO:0007506)	8.36554354
2	nuclear pore complex assembly (GO:0051292)	7.99993539
3	nuclear pore organization (GO:0006999)	6.96990416
4	pore complex assembly (GO:0046931)	6.08602927
5	regulation of translational fidelity (GO:0006450)	5.11166164
6	formation of translation preinitiation complex (GO:0001731)	5.02042337
7	DNA replication checkpoint (GO:0000076)	4.85917370
8	DNA unwinding involved in DNA replication (GO:0006268)	4.77154782
9	mitotic chromosome condensation (GO:0007076)	4.76493494
10	synapsis (GO:0007129)	4.49611603
11	resolution of meiotic recombination intermediates (GO:0000712)	4.48315925
12	ribosomal small subunit assembly (GO:0000028)	4.40669397
13	mitotic nuclear envelope disassembly (GO:0007077)	4.34799736
14	meiotic chromosome segregation (GO:0045132)	4.30312789
15	DNA replication initiation (GO:0006270)	4.17761192
16	DNA strand elongation involved in DNA replication (GO:0006271)	4.14045606
17	regulation of RNA export from nucleus (GO:0046831)	4.13823468
18	DNA strand elongation (GO:0022616)	4.06801454
19	ribosomal large subunit biogenesis (GO:0042273)	4.06536709
20	membrane disassembly (GO:0030397)	4.06212428
21	nuclear envelope disassembly (GO:0051081)	4.06212428
22	mitotic sister chromatid segregation (GO:0000070)	4.04146975
23	sister chromatid segregation (GO:0000819)	3.98784782
24	Golgi transport vesicle coating (GO:0048200)	3.96699842
25	COPI coating of Golgi vesicle (GO:0048205)	3.96699842
26	proline biosynthetic process (GO:0006561)	3.87620176
27	ribosomal small subunit biogenesis (GO:0042274)	3.87538050
28	folic acid-containing compound biosynthetic process (GO:0009396)	3.83372040
29	tRNA aminoacylation for protein translation (GO:0006418)	3.82565419
30	telomere maintenance via semi-conservative replication (GO:0032201)	3.77515243
31	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.76020956
32	DNA methylation involved in gamete generation (GO:0043046)	3.70124591
33	tRNA aminoacylation (GO:0043039)	3.68967430
34	amino acid activation (GO:0043038)	3.68967430
35	viral transcription (GO:0019083)	3.68440342
36	homocysteine metabolic process (GO:0050667)	3.67192152
37	ribonucleoprotein complex biogenesis (GO:0022613)	3.64106252
38	regulation of histone H3-K27 methylation (GO:0061085)	3.62918239
39	translational termination (GO:0006415)	3.62389389
40	regulation of histone H3-K4 methylation (GO:0051569)	3.58485509
41	DNA topological change (GO:0006265)	3.57094220
42	diterpenoid biosynthetic process (GO:0016102)	3.56317475
43	ribosome biogenesis (GO:0042254)	3.49234090
44	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.48987332
45	regulation of mitotic spindle organization (GO:0060236)	3.48616314
46	mitotic sister chromatid cohesion (GO:0007064)	3.44489419
47	piRNA metabolic process (GO:0034587)	3.43517428
48	regulation of nucleobase-containing compound transport (GO:0032239)	3.35395152
49	mitotic recombination (GO:0006312)	3.33927619
50	regulation of centriole replication (GO:0046599)	3.33450997
51	translational initiation (GO:0006413)	3.33000361
52	telomere maintenance via recombination (GO:0000722)	3.31955388
53	ribosome assembly (GO:0042255)	3.31014479
54	protoporphyrinogen IX metabolic process (GO:0046501)	3.29476447
55	purine nucleobase biosynthetic process (GO:0009113)	3.29137462
56	DNA synthesis involved in DNA repair (GO:0000731)	3.28402288
57	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.27219562
58	chromosome segregation (GO:0007059)	3.26092703
59	mitotic metaphase plate congression (GO:0007080)	3.24542712
60	protein localization to chromosome, centromeric region (GO:0071459)	3.24307550
61	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.22009655
62	chromosome condensation (GO:0030261)	3.21722775
63	translational elongation (GO:0006414)	3.21334857
64	cotranslational protein targeting to membrane (GO:0006613)	3.17308573
65	gas transport (GO:0015669)	3.17229494
66	regulation of translational elongation (GO:0006448)	3.16393614
67	oxidative phosphorylation (GO:0006119)	3.15826033
68	protein targeting to ER (GO:0045047)	3.12672989
69	regulation of centrosome cycle (GO:0046605)	3.12287225
70	IMP biosynthetic process (GO:0006188)	3.11312482
71	protein localization to kinetochore (GO:0034501)	3.09836325
72	protein export from nucleus (GO:0006611)	3.09131730
73	nucleobase-containing small molecule interconversion (GO:0015949)	3.07994349
74	poly(A)+ mRNA export from nucleus (GO:0016973)	3.06982455
75	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.06832946
76	maturation of SSU-rRNA (GO:0030490)	3.05684975
77	kinetochore organization (GO:0051383)	3.04423931
78	tetrahydrofolate metabolic process (GO:0046653)	3.03567883
79	chromosome organization involved in meiosis (GO:0070192)	3.03202602
80	DNA packaging (GO:0006323)	3.02071125
81	protein localization to endoplasmic reticulum (GO:0070972)	3.01699544
82	cellular protein complex disassembly (GO:0043624)	2.98787183
83	nuclear envelope organization (GO:0006998)	2.96608285
84	terpenoid biosynthetic process (GO:0016114)	2.96091232
85	nucleobase biosynthetic process (GO:0046112)	2.92023306
86	regulation of histone methylation (GO:0031060)	2.91622081
87	viral life cycle (GO:0019058)	2.88635172
88	microtubule depolymerization (GO:0007019)	2.86139363
89	metaphase plate congression (GO:0051310)	2.85516436
90	DNA conformation change (GO:0071103)	2.85253087
91	CENP-A containing nucleosome assembly (GO:0034080)	2.84664983
92	protein complex disassembly (GO:0043241)	2.82306559
93	midgut development (GO:0007494)	2.82001426
94	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.81152436
95	gene silencing by RNA (GO:0031047)	2.80127575
96	macromolecular complex disassembly (GO:0032984)	2.77513978
97	regulation of histone H3-K9 methylation (GO:0051570)	2.76345034
98	oxygen transport (GO:0015671)	2.74996506
99	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.74661929
100	definitive hemopoiesis (GO:0060216)	2.73812889

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.30384636
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.94481982
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.84497347
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.77469899
5	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.48021177
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.32549108
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.32376682
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14058855
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.00422908
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.83813223
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.72878244
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.69954185
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.56750536
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.56578421
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51958368
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.49925712
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48072768
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.38951056
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.35160869
20	DCP1A_22483619_ChIP-Seq_HELA_Human	2.33718417
21	ZNF263_19887448_ChIP-Seq_K562_Human	2.32955102
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31891516
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.21536218
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.18501238
25	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.11967584
26	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10419909
27	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.10265689
28	TTF2_22483619_ChIP-Seq_HELA_Human	2.07655931
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06059260
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.03242261
31	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.97360780
32	NCOR1_26117541_ChIP-Seq_K562_Human	1.96746326
33	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.96349717
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91788428
35	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.90066446
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.89751290
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.80533595
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.79416996
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.78269693
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.77419314
41	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.76883109
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72847409
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.62983692
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.55184530
45	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.53064486
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.52162233
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50829903
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50204380
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47994711
50	TFEB_21752829_ChIP-Seq_HELA_Human	1.45823286
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.44408452
52	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.44102456
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.41516613
54	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.40918771
55	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37073855
56	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.34652611
57	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.31927533
58	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.29392069
59	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.29301241
60	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.29299277
61	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.24628095
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24139743
63	GATA1_19941826_ChIP-Seq_K562_Human	1.23883843
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23111880
65	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22017910
66	MYC_22102868_ChIP-Seq_BL_Human	1.21490141
67	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.20521636
68	GATA1_22025678_ChIP-Seq_K562_Human	1.19240291
69	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18736794
70	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17238860
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14940983
72	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.13115406
73	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12027910
74	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.06990375
75	GATA2_19941826_ChIP-Seq_K562_Human	1.05890636
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.03180015
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01864626
78	CHD1_26751641_Chip-Seq_LNCaP_Human	1.01528358
79	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.00463832
80	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99029500
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98438131
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.97653892
83	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.97481426
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.96772339
85	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.91102196
86	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.90737652
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89399713
88	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.84914285
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.84165335
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.83962490
91	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.81504009
92	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.80401479
93	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.80317517
94	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.78493539
95	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.78384787
96	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.78340867
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.77955271
98	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.77926263
99	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.77293895
100	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.76893867

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004957_abnormal_blastocyst_morpholog	4.34999764
2	MP0008058_abnormal_DNA_repair	3.89544250
3	MP0003693_abnormal_embryo_hatching	3.79510435
4	MP0010094_abnormal_chromosome_stability	3.75540365
5	MP0003111_abnormal_nucleus_morphology	3.53065654
6	MP0008057_abnormal_DNA_replication	3.47956651
7	MP0004147_increased_porphyrin_level	3.13400121
8	MP0003077_abnormal_cell_cycle	3.12488728
9	MP0005451_abnormal_body_composition	2.99038946
10	MP0009697_abnormal_copulation	2.90203592
11	MP0008995_early_reproductive_senescence	2.83410406
12	MP0008932_abnormal_embryonic_tissue	2.80226478
13	MP0008007_abnormal_cellular_replicative	2.77548117
14	MP0003786_premature_aging	2.39418151
15	MP0010307_abnormal_tumor_latency	2.17891350
16	MP0003656_abnormal_erythrocyte_physiolo	2.14797589
17	MP0000678_abnormal_parathyroid_gland	2.09987269
18	MP0000350_abnormal_cell_proliferation	2.03593758
19	MP0004233_abnormal_muscle_weight	2.02708580
20	MP0002009_preneoplasia	2.02243249
21	MP0001730_embryonic_growth_arrest	1.98269302
22	MP0005083_abnormal_biliary_tract	1.97870229
23	MP0003718_maternal_effect	1.89843301
24	MP0006035_abnormal_mitochondrial_morpho	1.84819847
25	MP0001697_abnormal_embryo_size	1.82635291
26	MP0002877_abnormal_melanocyte_morpholog	1.79920651
27	MP0001661_extended_life_span	1.77696505
28	MP0002210_abnormal_sex_determination	1.76654661
29	MP0001929_abnormal_gametogenesis	1.70876045
30	MP0002080_prenatal_lethality	1.66225549
31	MP0004808_abnormal_hematopoietic_stem	1.65483941
32	MP0005380_embryogenesis_phenotype	1.62154224
33	MP0001672_abnormal_embryogenesis/_devel	1.62154224
34	MP0003806_abnormal_nucleotide_metabolis	1.61792508
35	MP0000313_abnormal_cell_death	1.60243123
36	MP0002396_abnormal_hematopoietic_system	1.57165861
37	MP0003984_embryonic_growth_retardation	1.53493054
38	MP0006036_abnormal_mitochondrial_physio	1.51474674
39	MP0000358_abnormal_cell_content/	1.50524350
40	MP0002088_abnormal_embryonic_growth/wei	1.48756547
41	MP0003186_abnormal_redox_activity	1.46066316
42	MP0005076_abnormal_cell_differentiation	1.44837832
43	MP0002086_abnormal_extraembryonic_tissu	1.40833555
44	MP0003221_abnormal_cardiomyocyte_apopto	1.36112772
45	MP0001145_abnormal_male_reproductive	1.34388743
46	MP0010352_gastrointestinal_tract_polyps	1.32852209
47	MP0005408_hypopigmentation	1.30212592
48	MP0002132_abnormal_respiratory_system	1.28595973
49	MP0003959_abnormal_lean_body	1.25636362
50	MP0002084_abnormal_developmental_patter	1.24446232
51	MP0000653_abnormal_sex_gland	1.21539966
52	MP0003698_abnormal_male_reproductive	1.21442281
53	MP0002085_abnormal_embryonic_tissue	1.13369374
54	MP0002019_abnormal_tumor_incidence	1.08957700
55	MP0004197_abnormal_fetal_growth/weight/	1.06017281
56	MP0005397_hematopoietic_system_phenotyp	1.05175046
57	MP0001545_abnormal_hematopoietic_system	1.05175046
58	MP0004145_abnormal_muscle_electrophysio	1.01706396
59	MP0001727_abnormal_embryo_implantation	1.01641433
60	MP0002269_muscular_atrophy	0.97413737
61	MP0001873_stomach_inflammation	0.96823303
62	MP0001764_abnormal_homeostasis	0.94024478
63	MP0000703_abnormal_thymus_morphology	0.92465134
64	MP0002161_abnormal_fertility/fecundity	0.91237130
65	MP0000747_muscle_weakness	0.88895270
66	MP0003385_abnormal_body_wall	0.86767844
67	MP0000490_abnormal_crypts_of	0.86437049
68	MP0003699_abnormal_female_reproductive	0.85379849
69	MP0005384_cellular_phenotype	0.84070074
70	MP0000609_abnormal_liver_physiology	0.80319376
71	MP0005410_abnormal_fertilization	0.80306230
72	MP0000598_abnormal_liver_morphology	0.76891547
73	MP0005621_abnormal_cell_physiology	0.75742440
74	MP0010630_abnormal_cardiac_muscle	0.75207542
75	MP0003950_abnormal_plasma_membrane	0.73388101
76	MP0001348_abnormal_lacrimal_gland	0.73139645
77	MP0005171_absent_coat_pigmentation	0.73103135
78	MP0005332_abnormal_amino_acid	0.72803361
79	MP0009931_abnormal_skin_appearance	0.71687268
80	MP0000647_abnormal_sebaceous_gland	0.71254326
81	MP0005636_abnormal_mineral_homeostasis	0.69408121
82	MP0009379_abnormal_foot_pigmentation	0.67604792
83	MP0001881_abnormal_mammary_gland	0.67309129
84	MP0005501_abnormal_skin_physiology	0.65362944
85	MP0005058_abnormal_lysosome_morphology	0.65330429
86	MP0008877_abnormal_DNA_methylation	0.64823878
87	MP0003123_paternal_imprinting	0.63470060
88	MP0002095_abnormal_skin_pigmentation	0.63208569
89	MP0003943_abnormal_hepatobiliary_system	0.62186625
90	MP0009703_decreased_birth_body	0.61685472
91	MP0009672_abnormal_birth_weight	0.61393546
92	MP0005647_abnormal_sex_gland	0.61199954
93	MP0008775_abnormal_heart_ventricle	0.60656332
94	MP0002160_abnormal_reproductive_system	0.60144367
95	MP0002722_abnormal_immune_system	0.59773568
96	MP0008770_decreased_survivor_rate	0.59664606
97	MP0009115_abnormal_fat_cell	0.59028344
98	MP0003941_abnormal_skin_development	0.58841648
99	MP0002398_abnormal_bone_marrow	0.57745589
100	MP0001915_intracranial_hemorrhage	0.57535608

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.88908460
2	Truncus arteriosus (HP:0001660)	4.85526656
3	Chromsome breakage (HP:0040012)	4.83794488
4	Cholecystitis (HP:0001082)	4.66496584
5	Abnormal gallbladder physiology (HP:0012438)	4.66496584
6	Reticulocytosis (HP:0001923)	4.28806510
7	Abnormality of reticulocytes (HP:0004312)	4.19344959
8	Ankyloglossia (HP:0010296)	4.16570651
9	Cortical dysplasia (HP:0002539)	4.00600520
10	Reticulocytopenia (HP:0001896)	3.99370572
11	Birth length less than 3rd percentile (HP:0003561)	3.77598435
12	Pallor (HP:0000980)	3.70539340
13	Hyperthyroidism (HP:0000836)	3.69646233
14	Polycythemia (HP:0001901)	3.66401777
15	Abnormal hemoglobin (HP:0011902)	3.52412948
16	Bowel incontinence (HP:0002607)	3.35776892
17	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.30389291
18	Acute myeloid leukemia (HP:0004808)	3.23691296
19	Abnormal large intestine physiology (HP:0012700)	3.19836899
20	Abnormality of oral frenula (HP:0000190)	3.12160785
21	Upper limb muscle weakness (HP:0003484)	3.11755259
22	Hypertensive crisis (HP:0100735)	3.01080868
23	Abnormality of the tricuspid valve (HP:0001702)	2.92846439
24	Abnormality of cells of the erythroid lineage (HP:0012130)	2.92559758
25	Homocystinuria (HP:0002156)	2.91196910
26	Abnormality of homocysteine metabolism (HP:0010919)	2.91196910
27	Abnormality of glycolysis (HP:0004366)	2.79451891
28	Seborrheic dermatitis (HP:0001051)	2.77193661
29	Poikilocytosis (HP:0004447)	2.75484372
30	Myelodysplasia (HP:0002863)	2.74903061
31	Overlapping toe (HP:0001845)	2.72348038
32	Macrocytic anemia (HP:0001972)	2.71114984
33	Hypoparathyroidism (HP:0000829)	2.65718609
34	Increased serum pyruvate (HP:0003542)	2.62930672
35	Abnormality of the preputium (HP:0100587)	2.58867564
36	Short middle phalanx of the 5th finger (HP:0004220)	2.50145672
37	Ileus (HP:0002595)	2.39782386
38	Hyperbilirubinemia (HP:0002904)	2.36761913
39	Abnormality of DNA repair (HP:0003254)	2.36757110
40	Abnormality of chromosome stability (HP:0003220)	2.36093669
41	Tinnitus (HP:0000360)	2.33284716
42	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32831278
43	Orthostatic hypotension (HP:0001278)	2.31520996
44	Acanthocytosis (HP:0001927)	2.31495517
45	Increased nuchal translucency (HP:0010880)	2.27844486
46	Cholelithiasis (HP:0001081)	2.26655677
47	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.25878849
48	Duplicated collecting system (HP:0000081)	2.25840987
49	Abnormality of cochlea (HP:0000375)	2.25068196
50	Abnormal number of erythroid precursors (HP:0012131)	2.22790637
51	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.22064706
52	Deep philtrum (HP:0002002)	2.20693332
53	Entropion (HP:0000621)	2.18914734
54	Sandal gap (HP:0001852)	2.18488971
55	Duodenal stenosis (HP:0100867)	2.17437933
56	Small intestinal stenosis (HP:0012848)	2.17437933
57	Abnormality of methionine metabolism (HP:0010901)	2.16285802
58	Cafe-au-lait spot (HP:0000957)	2.15252652
59	Atelectasis (HP:0100750)	2.14745482
60	Cutaneous melanoma (HP:0012056)	2.12927572
61	Pheochromocytoma (HP:0002666)	2.07073457
62	Microvesicular hepatic steatosis (HP:0001414)	2.05944797
63	Progressive external ophthalmoplegia (HP:0000590)	2.05493900
64	Abnormality of the renal collecting system (HP:0004742)	1.99115809
65	Breech presentation (HP:0001623)	1.97907428
66	Abnormal gallbladder morphology (HP:0012437)	1.95833683
67	Redundant skin (HP:0001582)	1.95457860
68	Fatigue (HP:0012378)	1.95161906
69	Termporal pattern (HP:0011008)	1.95049641
70	Insidious onset (HP:0003587)	1.95049641
71	Thrombocytosis (HP:0001894)	1.93982239
72	Relative macrocephaly (HP:0004482)	1.93161236
73	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.90233112
74	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.86167544
75	Submucous cleft hard palate (HP:0000176)	1.85598306
76	Meningioma (HP:0002858)	1.84880178
77	Progressive muscle weakness (HP:0003323)	1.83100105
78	Hyperammonemia (HP:0001987)	1.81224446
79	Dysmetric saccades (HP:0000641)	1.79705797
80	Secondary amenorrhea (HP:0000869)	1.79684261
81	Neoplasm of the peripheral nervous system (HP:0100007)	1.79507841
82	Male infertility (HP:0003251)	1.78926494
83	Increased hepatocellular lipid droplets (HP:0006565)	1.78741130
84	Abnormally folded helix (HP:0008544)	1.78715240
85	Nonimmune hydrops fetalis (HP:0001790)	1.77966029
86	Neuroendocrine neoplasm (HP:0100634)	1.77468567
87	Meckel diverticulum (HP:0002245)	1.77460319
88	Cerebral hypomyelination (HP:0006808)	1.74341544
89	Adenoma sebaceum (HP:0009720)	1.73607485
90	Angiofibromas (HP:0010615)	1.73607485
91	Morphological abnormality of the inner ear (HP:0011390)	1.72598239
92	Septate vagina (HP:0001153)	1.72401108
93	Neoplasm of head and neck (HP:0012288)	1.72240792
94	Esophageal neoplasm (HP:0100751)	1.72240792
95	Premature ovarian failure (HP:0008209)	1.72120380
96	Poikiloderma (HP:0001029)	1.71531778
97	Ependymoma (HP:0002888)	1.69742817
98	Sparse lateral eyebrow (HP:0005338)	1.67520373
99	Abnormality of the carotid arteries (HP:0005344)	1.66912491
100	Abnormality of the gallbladder (HP:0005264)	1.66766839

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KSR2	3.55708170
2	TTK	3.46882175
3	EIF2AK1	3.38690195
4	RIPK4	3.21302926
5	EEF2K	3.01849214
6	NEK1	3.01459042
7	PBK	2.87219276
8	CDC7	2.65874332
9	SCYL2	2.61638885
10	RAF1	2.48953139
11	CLK1	2.45626666
12	BMPR2	2.40544068
13	MAP3K2	2.39569060
14	WEE1	2.39128878
15	RPS6KB2	2.26257126
16	CCNB1	2.14448591
17	BRSK2	2.12373747
18	IRAK3	2.04303461
19	EIF2AK3	1.99412982
20	PLK4	1.97343707
21	SRPK1	1.94398094
22	CDK12	1.91201763
23	NME2	1.87550851
24	BUB1	1.82439203
25	KSR1	1.73432563
26	NTRK3	1.63121163
27	TSSK6	1.61894539
28	NEK2	1.52912551
29	CHEK2	1.47262374
30	PRPF4B	1.28941634
31	MAP3K8	1.27476467
32	BRSK1	1.26807641
33	PDK2	1.26171825
34	BRAF	1.22959381
35	PIK3CG	1.16006176
36	YES1	1.13252130
37	CHEK1	1.10596884
38	ICK	1.07234062
39	MST4	1.05136028
40	NME1	1.04899466
41	ATR	1.02176517
42	MAP3K4	1.01760706
43	AKT3	1.00166629
44	CDK7	0.97983006
45	PLK1	0.95455777
46	ALK	0.94170827
47	BMX	0.93453156
48	AURKB	0.88924530
49	STK3	0.83000830
50	CDK8	0.82950802
51	ATM	0.82316647
52	PLK3	0.80375389
53	ZAK	0.78511122
54	CDK1	0.75085859
55	RET	0.69902987
56	NEK6	0.68761449
57	ACVR1B	0.67216234
58	PAK2	0.66696216
59	TAOK2	0.66646739
60	PAK1	0.65853001
61	ILK	0.65061192
62	CDK2	0.65057362
63	TRPM7	0.64154763
64	WNK4	0.63881138
65	PASK	0.63244737
66	JAK2	0.63048514
67	BRD4	0.62045149
68	MAP2K1	0.59128348
69	MUSK	0.58946408
70	AURKA	0.56760292
71	CSNK2A2	0.56646109
72	STK4	0.53787042
73	ERBB4	0.51127349
74	MAP3K1	0.49853201
75	CDK4	0.48464314
76	PAK4	0.48287698
77	TRIB3	0.46587013
78	MTOR	0.45660331
79	PIM1	0.45118083
80	CSNK2A1	0.40068893
81	STK16	0.39009827
82	EIF2AK2	0.38084843
83	RPS6KB1	0.36231587
84	IRAK4	0.35946952
85	MAP3K6	0.35609162
86	WNK1	0.34929914
87	CSNK1E	0.34909188
88	LATS1	0.34904275
89	MAP3K13	0.34898325
90	LATS2	0.33520154
91	RPS6KA4	0.32148982
92	MARK3	0.29930986
93	MAPK14	0.29507700
94	RPS6KA5	0.28982522
95	MAPK10	0.28305864
96	MKNK1	0.28039419
97	LRRK2	0.27531116
98	PRKDC	0.25864517
99	MAP3K14	0.25725884
100	JAK3	0.25498522

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.40599315
2	DNA replication_Homo sapiens_hsa03030	3.87709868
3	Mismatch repair_Homo sapiens_hsa03430	3.74353212
4	Ribosome_Homo sapiens_hsa03010	3.22027260
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.15626673
6	One carbon pool by folate_Homo sapiens_hsa00670	3.13229482
7	RNA transport_Homo sapiens_hsa03013	2.62721940
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.53800549
9	Homologous recombination_Homo sapiens_hsa03440	2.39621474
10	Cell cycle_Homo sapiens_hsa04110	2.35255411
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.23913716
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.20582331
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04421753
14	Spliceosome_Homo sapiens_hsa03040	2.02268068
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.72404743
16	Basal transcription factors_Homo sapiens_hsa03022	1.71488911
17	Base excision repair_Homo sapiens_hsa03410	1.66239414
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.63339052
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.63083131
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.59244563
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.57742422
22	Carbon metabolism_Homo sapiens_hsa01200	1.49122046
23	RNA polymerase_Homo sapiens_hsa03020	1.41545634
24	Acute myeloid leukemia_Homo sapiens_hsa05221	1.37127281
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32922117
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.31987047
27	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.31049873
28	Proteasome_Homo sapiens_hsa03050	1.30097490
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29791560
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.29767604
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.24080490
32	Arginine biosynthesis_Homo sapiens_hsa00220	1.23797364
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17244183
34	RNA degradation_Homo sapiens_hsa03018	1.16875884
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.08132479
36	Pentose phosphate pathway_Homo sapiens_hsa00030	1.07569027
37	Thyroid cancer_Homo sapiens_hsa05216	1.04900953
38	Pancreatic cancer_Homo sapiens_hsa05212	1.04275148
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.01974191
40	Viral carcinogenesis_Homo sapiens_hsa05203	1.00983684
41	Protein export_Homo sapiens_hsa03060	0.99652474
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.98483036
43	mTOR signaling pathway_Homo sapiens_hsa04150	0.95145846
44	Non-small cell lung cancer_Homo sapiens_hsa05223	0.94459036
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92078341
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.91002595
47	Purine metabolism_Homo sapiens_hsa00230	0.90174724
48	Oocyte meiosis_Homo sapiens_hsa04114	0.90067654
49	Propanoate metabolism_Homo sapiens_hsa00640	0.85030384
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.84262885
51	ErbB signaling pathway_Homo sapiens_hsa04012	0.79181732
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78850292
53	Renal cell carcinoma_Homo sapiens_hsa05211	0.78220512
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76382362
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.75736311
56	Huntingtons disease_Homo sapiens_hsa05016	0.73420127
57	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.73006539
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72741677
59	Parkinsons disease_Homo sapiens_hsa05012	0.68159881
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65688378
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.64069223
62	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.60839225
63	Folate biosynthesis_Homo sapiens_hsa00790	0.60493337
64	VEGF signaling pathway_Homo sapiens_hsa04370	0.59882411
65	Sulfur relay system_Homo sapiens_hsa04122	0.55252328
66	p53 signaling pathway_Homo sapiens_hsa04115	0.54604016
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54132223
68	Alcoholism_Homo sapiens_hsa05034	0.53474641
69	Oxidative phosphorylation_Homo sapiens_hsa00190	0.52577186
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52077780
71	Insulin signaling pathway_Homo sapiens_hsa04910	0.51305641
72	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50659121
73	Glioma_Homo sapiens_hsa05214	0.49969401
74	Bladder cancer_Homo sapiens_hsa05219	0.49898515
75	Olfactory transduction_Homo sapiens_hsa04740	0.49291576
76	Colorectal cancer_Homo sapiens_hsa05210	0.45775648
77	Prolactin signaling pathway_Homo sapiens_hsa04917	0.45315336
78	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44159969
79	Prion diseases_Homo sapiens_hsa05020	0.43372597
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.40825062
81	Hepatitis B_Homo sapiens_hsa05161	0.39983760
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38184933
83	Endometrial cancer_Homo sapiens_hsa05213	0.38013965
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37599864
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37117968
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37114160
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.33956946
88	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33434138
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32335362
90	Metabolic pathways_Homo sapiens_hsa01100	0.31983997
91	Fatty acid elongation_Homo sapiens_hsa00062	0.30807743
92	Prostate cancer_Homo sapiens_hsa05215	0.30319354
93	Glutathione metabolism_Homo sapiens_hsa00480	0.26408467
94	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.26361311
95	Alzheimers disease_Homo sapiens_hsa05010	0.26286411
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26061367
97	Shigellosis_Homo sapiens_hsa05131	0.25141218
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.24323909
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.23643492
100	Apoptosis_Homo sapiens_hsa04210	0.23472680

CT45A10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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