CT45A11P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucocorticoid secretion (GO:2000849)8.81780880
2positive regulation of steroid hormone secretion (GO:2000833)8.74424339
3exploration behavior (GO:0035640)7.77482452
4positive regulation of calcium ion import (GO:0090280)7.76254521
5negative regulation of catecholamine secretion (GO:0033604)7.70099571
6synaptic transmission, dopaminergic (GO:0001963)7.64131108
7hypothalamus development (GO:0021854)7.61344842
8regulation of corticosteroid hormone secretion (GO:2000846)7.33803684
9positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003577.03876173
10thalamus development (GO:0021794)6.81767907
11glucocorticoid metabolic process (GO:0008211)6.51680390
12ether metabolic process (GO:0018904)6.48310437
13positive regulation of circadian rhythm (GO:0042753)6.30026768
14negative regulation of circadian rhythm (GO:0042754)6.20506672
15regulation of norepinephrine secretion (GO:0014061)6.12762410
16microtubule severing (GO:0051013)6.04791454
17protein polyglutamylation (GO:0018095)6.01409471
18regulation of circadian sleep/wake cycle (GO:0042749)5.94974176
19regulation of circadian sleep/wake cycle, sleep (GO:0045187)5.94974176
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.87874356
21cellular response to dexamethasone stimulus (GO:0071549)5.79935493
22response to dexamethasone (GO:0071548)5.39972199
23neuronal ion channel clustering (GO:0045161)5.34845258
24regulation of steroid hormone secretion (GO:2000831)5.29871692
25genitalia morphogenesis (GO:0035112)5.24838004
26cellular response to ammonium ion (GO:0071242)5.09869754
27regulation of calcium ion import (GO:0090279)4.84735848
28circadian sleep/wake cycle process (GO:0022410)4.77464220
29sequestering of extracellular ligand from receptor (GO:0035581)4.51705901
30cardiovascular system development (GO:0072358)4.51597264
31regulation of cilium movement (GO:0003352)4.46685869
32negative regulation of amine transport (GO:0051953)4.36131961
33CDP-diacylglycerol metabolic process (GO:0046341)4.24062702
34response to corticosterone (GO:0051412)4.17405342
35glycerophospholipid catabolic process (GO:0046475)4.07114377
36long-term memory (GO:0007616)4.06144115
37adrenal gland development (GO:0030325)4.02569306
38striatum development (GO:0021756)3.92127333
39Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.91089487
40CDP-diacylglycerol biosynthetic process (GO:0016024)3.86033725
41regulation of establishment of planar polarity (GO:0090175)3.81372640
42negative regulation of neurotransmitter secretion (GO:0046929)3.80187917
43cartilage condensation (GO:0001502)3.73245466
44cell aggregation (GO:0098743)3.73245466
45embryonic body morphogenesis (GO:0010172)3.72950185
46response to pain (GO:0048265)3.67337884
47eating behavior (GO:0042755)3.66241891
48regulation of receptor binding (GO:1900120)3.57861590
49response to mineralocorticoid (GO:0051385)3.57501728
50adult walking behavior (GO:0007628)3.50890847
51regulation of digestive system process (GO:0044058)3.50308303
52cell migration in hindbrain (GO:0021535)3.46480866
53body morphogenesis (GO:0010171)3.43471844
54long-term synaptic potentiation (GO:0060291)3.39818576
55forebrain neuron development (GO:0021884)3.39511944
56phosphatidylglycerol biosynthetic process (GO:0006655)3.36336382
57sulfur amino acid catabolic process (GO:0000098)3.35892815
58phosphorelay signal transduction system (GO:0000160)3.32111376
59regulation of telomerase activity (GO:0051972)3.29171490
60regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.27720371
61regulation of microtubule-based movement (GO:0060632)3.13659252
62phosphorylated carbohydrate dephosphorylation (GO:0046838)3.09192034
63inositol phosphate dephosphorylation (GO:0046855)3.09192034
64regulation of glutamate receptor signaling pathway (GO:1900449)3.03697057
65negative regulation of blood pressure (GO:0045776)3.02695283
66synaptic vesicle endocytosis (GO:0048488)3.02172220
67positive regulation of protein depolymerization (GO:1901881)3.01471116
68neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.96783292
69paraxial mesoderm development (GO:0048339)2.96591769
70regulation of catecholamine secretion (GO:0050433)2.93613535
71circadian behavior (GO:0048512)2.92226942
72cellular response to ketone (GO:1901655)2.91272746
73polyol catabolic process (GO:0046174)2.84830750
74cellular response to alkaloid (GO:0071312)2.82474258
75regulation of axon regeneration (GO:0048679)2.82116902
76regulation of neuron projection regeneration (GO:0070570)2.82116902
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.80597330
78NADH dehydrogenase complex assembly (GO:0010257)2.80597330
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80597330
80positive regulation of protein complex disassembly (GO:0043243)2.79598704
81somitogenesis (GO:0001756)2.79138759
82substrate-independent telencephalic tangential migration (GO:0021826)2.78847169
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.78847169
84rhythmic behavior (GO:0007622)2.77403275
85protein localization to cilium (GO:0061512)2.76968176
86inositol phosphate catabolic process (GO:0071545)2.76848105
87response to ischemia (GO:0002931)2.73766394
88regulation of endocrine process (GO:0044060)2.73426852
89non-canonical Wnt signaling pathway (GO:0035567)2.73042211
90positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.72744014
91positive regulation of DNA biosynthetic process (GO:2000573)2.72696876
92cellular response to glucocorticoid stimulus (GO:0071385)2.71750032
93locomotory exploration behavior (GO:0035641)13.4840143
94protein neddylation (GO:0045116)12.0793592
95regulation of gonadotropin secretion (GO:0032276)12.0042262
96phenylpropanoid metabolic process (GO:0009698)11.9331935
97negative regulation of norepinephrine secretion (GO:0010700)11.8047955
98glucocorticoid biosynthetic process (GO:0006704)10.9496651
99parturition (GO:0007567)10.9351231
100positive regulation of digestive system process (GO:0060456)10.7891190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.25960669
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.91245725
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.84492286
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.19709316
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.14940235
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.08121701
7ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.07705301
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09363892
9REST_21632747_ChIP-Seq_MESCs_Mouse2.09215420
10GATA1_26923725_Chip-Seq_HPCs_Mouse1.98044295
11CBX2_27304074_Chip-Seq_ESCs_Mouse1.86668188
12SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.79197932
13ZNF274_21170338_ChIP-Seq_K562_Hela1.77165708
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75704661
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.72718037
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66480204
17MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64425001
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64137815
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.63276552
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58235107
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57629005
22CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57185868
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56086084
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53769500
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51757606
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.49459720
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46770761
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45910772
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45910772
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45125383
31RNF2_27304074_Chip-Seq_NSC_Mouse1.41038113
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39554428
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38449418
34AR_25329375_ChIP-Seq_VCAP_Human1.36876877
35HTT_18923047_ChIP-ChIP_STHdh_Human1.34070346
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.32624740
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.31744283
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30719053
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27006093
40IGF1R_20145208_ChIP-Seq_DFB_Human1.26981505
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.26484333
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.25473999
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25267060
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23624820
45MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.23603677
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23285141
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21663085
48TAF15_26573619_Chip-Seq_HEK293_Human1.18506710
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18006054
50RXR_22108803_ChIP-Seq_LS180_Human1.15800039
51JUN_21703547_ChIP-Seq_K562_Human1.15629001
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14742327
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.14549391
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14234251
55EWS_26573619_Chip-Seq_HEK293_Human1.11874997
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11669619
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.11669619
58JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10131419
59POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.09866311
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.09812861
61OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09349212
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07691400
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.06983369
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.06449250
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03753131
66SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02733378
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.01771558
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99965860
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99253252
70P53_22387025_ChIP-Seq_ESCs_Mouse0.99030210
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96721792
72CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96449341
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.95986534
74SMRT_27268052_Chip-Seq_Bcells_Human0.95535686
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94702697
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94617730
77TP53_20018659_ChIP-ChIP_R1E_Mouse0.93391216
78JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91547047
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91273725
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90568976
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90107142
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90107142
83TAL1_26923725_Chip-Seq_HPCs_Mouse0.89303507
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87046668
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86834364
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.86224153
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85767305
88VDR_22108803_ChIP-Seq_LS180_Human0.84430177
89IRF1_19129219_ChIP-ChIP_H3396_Human0.83344135
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83125164
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82574524
92CTCF_27219007_Chip-Seq_Bcells_Human0.82406034
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80919064
94BCL6_27268052_Chip-Seq_Bcells_Human0.79958298
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.78834569
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78822218
97PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.78527883
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78452326
99TCF4_23295773_ChIP-Seq_U87_Human0.78132195
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77616368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.66045551
2MP0010030_abnormal_orbit_morphology6.09027283
3MP0001348_abnormal_lacrimal_gland6.08988047
4MP0000569_abnormal_digit_pigmentation5.71150345
5MP0004782_abnormal_surfactant_physiolog5.64005824
6MP0004859_abnormal_synaptic_plasticity4.10681906
7MP0002653_abnormal_ependyma_morphology3.03023292
8MP0005423_abnormal_somatic_nervous2.69192535
9MP0003718_maternal_effect2.62235928
10MP0000049_abnormal_middle_ear2.25529083
11MP0000749_muscle_degeneration2.22241342
12MP0002127_abnormal_cardiovascular_syste2.07847961
13MP0005551_abnormal_eye_electrophysiolog2.03425990
14MP0003283_abnormal_digestive_organ1.85705530
15MP0005174_abnormal_tail_pigmentation1.80332335
16MP0008789_abnormal_olfactory_epithelium1.73955402
17MP0000015_abnormal_ear_pigmentation1.73872789
18MP0002184_abnormal_innervation1.72732481
19MP0001986_abnormal_taste_sensitivity1.66522252
20MP0000955_abnormal_spinal_cord1.62536372
21MP0003938_abnormal_ear_development1.58423220
22MP0002733_abnormal_thermal_nociception1.58219570
23MP0003787_abnormal_imprinting1.56220187
24MP0005499_abnormal_olfactory_system1.53323431
25MP0005394_taste/olfaction_phenotype1.53323431
26MP0001529_abnormal_vocalization1.49935938
27MP0000639_abnormal_adrenal_gland1.49457226
28MP0000026_abnormal_inner_ear1.38870385
29MP0003880_abnormal_central_pattern1.37042074
30MP0002752_abnormal_somatic_nervous1.36291395
31MP0002932_abnormal_joint_morphology1.34448226
32MP0001970_abnormal_pain_threshold1.29939248
33MP0003123_paternal_imprinting1.29057375
34MP0008775_abnormal_heart_ventricle1.26746260
35MP0003959_abnormal_lean_body1.25626704
36MP0002233_abnormal_nose_morphology1.23803396
37MP0000778_abnormal_nervous_system1.13013868
38MP0001340_abnormal_eyelid_morphology1.11852281
39MP0002229_neurodegeneration1.11132808
40MP0003890_abnormal_embryonic-extraembry1.11084360
41MP0001324_abnormal_eye_pigmentation1.11056230
42MP0002751_abnormal_autonomic_nervous1.09424540
43MP0004510_myositis1.08770158
44MP0002272_abnormal_nervous_system1.08401890
45MP0003329_amyloid_beta_deposits1.08249525
46MP0005167_abnormal_blood-brain_barrier1.07738810
47MP0006276_abnormal_autonomic_nervous1.04691940
48MP0009384_cardiac_valve_regurgitation1.04509516
49MP0004133_heterotaxia1.04244624
50MP0002882_abnormal_neuron_morphology1.00878602
51MP0001299_abnormal_eye_distance/0.94679887
52MP0004134_abnormal_chest_morphology0.94272057
53MP0000604_amyloidosis0.93361970
54MP0001663_abnormal_digestive_system0.90812431
55MP0002572_abnormal_emotion/affect_behav0.88596959
56MP0003221_abnormal_cardiomyocyte_apopto0.87703531
57MP0009764_decreased_sensitivity_to0.87375658
58MP0005381_digestive/alimentary_phenotyp0.78747555
59MP0003011_delayed_dark_adaptation0.77422238
60MP0001984_abnormal_olfaction0.76902050
61MP0003937_abnormal_limbs/digits/tail_de0.74945158
62MP0005395_other_phenotype0.73014212
63MP0006035_abnormal_mitochondrial_morpho0.70167636
64MP0002109_abnormal_limb_morphology0.69080950
65MP0001188_hyperpigmentation0.68893442
66MP0003755_abnormal_palate_morphology0.67550569
67MP0000343_altered_response_to0.67546887
68MP0005508_abnormal_skeleton_morphology0.67477338
69MP0003635_abnormal_synaptic_transmissio0.66021917
70MP0009046_muscle_twitch0.65831781
71MP0001286_abnormal_eye_development0.65597691
72MP0002928_abnormal_bile_duct0.64826846
73MP0003690_abnormal_glial_cell0.64577059
74MP0003115_abnormal_respiratory_system0.64484469
75MP0002557_abnormal_social/conspecific_i0.63926028
76MP0003879_abnormal_hair_cell0.63036554
77MP0002111_abnormal_tail_morphology0.60630264
78MP0002064_seizures0.60252587
79MP0005388_respiratory_system_phenotype0.58998854
80MP0002133_abnormal_respiratory_system0.58998854
81MP0003186_abnormal_redox_activity0.58385837
82MP0004811_abnormal_neuron_physiology0.57408368
83MP0005195_abnormal_posterior_eye0.57070519
84MP0002177_abnormal_outer_ear0.55633922
85MP0002067_abnormal_sensory_capabilities0.55142765
86MP0003942_abnormal_urinary_system0.53353569
87MP0004084_abnormal_cardiac_muscle0.52723580
88MP0002152_abnormal_brain_morphology0.51269235
89MP0006082_CNS_inflammation0.50602230
90MP0004883_abnormal_blood_vessel0.50401427
91MP0002116_abnormal_craniofacial_bone0.50205995
92MP0001440_abnormal_grooming_behavior0.49944223
93MP0009250_abnormal_appendicular_skeleto0.49253690
94MP0001968_abnormal_touch/_nociception0.48141253
95MP0003121_genomic_imprinting0.47264878
96MP0005535_abnormal_body_temperature0.45414139
97MP0009745_abnormal_behavioral_response0.44324053
98MP0002063_abnormal_learning/memory/cond0.44280012
99MP0002896_abnormal_bone_mineralization0.44202616
100MP0002638_abnormal_pupillary_reflex0.43638359

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)7.96125075
2Short middle phalanx of the 5th finger (HP:0004220)7.88590358
3Aplasia/Hypoplasia of the sacrum (HP:0008517)6.43741827
4Mesomelia (HP:0003027)6.22693799
5Abnormality of the distal phalanges of the toes (HP:0010182)6.12358801
6Myotonia (HP:0002486)5.78911523
7Thoracolumbar scoliosis (HP:0002944)5.73340741
8Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)5.27647185
9Hypoplastic labia majora (HP:0000059)5.20797224
10Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.84774997
11Ankyloglossia (HP:0010296)4.83834313
12Bifid tongue (HP:0010297)4.80208746
13Abnormality of the labia majora (HP:0012881)4.77075028
14Abnormality of the right ventricle (HP:0001707)4.74183221
15Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.63681544
16Anomalous pulmonary venous return (HP:0010772)4.63236694
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.41067985
18Symphalangism affecting the phalanges of the hand (HP:0009773)4.25540205
19Increased IgM level (HP:0003496)4.11844889
20Abnormality of the phalanges of the 5th finger (HP:0004213)4.10504624
21Renal duplication (HP:0000075)4.10194886
22Abnormality of the pulmonary veins (HP:0011718)4.04206440
23Missing ribs (HP:0000921)3.99876351
24Long palpebral fissure (HP:0000637)3.69435327
25Increased number of teeth (HP:0011069)3.67794531
26Abnormality of oral frenula (HP:0000190)3.59436926
27Growth hormone deficiency (HP:0000824)3.55577765
28Short 5th finger (HP:0009237)3.50429744
29Labial hypoplasia (HP:0000066)3.49461800
30Hemivertebrae (HP:0002937)3.43246069
31Tented upper lip vermilion (HP:0010804)3.41333759
32Cutaneous finger syndactyly (HP:0010554)3.24246876
33Hypoplastic female external genitalia (HP:0012815)3.21404692
34Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.21250169
35Increased serum pyruvate (HP:0003542)3.16647725
36Supranuclear gaze palsy (HP:0000605)3.08422219
37Aplasia/Hypoplasia of the uvula (HP:0010293)3.04750251
38Hypophosphatemic rickets (HP:0004912)3.02997071
39Small hand (HP:0200055)2.97827447
40Progressive neurologic deterioration (HP:0002344)2.89803054
41Disproportionate short-trunk short stature (HP:0003521)2.88702138
42Cutaneous syndactyly (HP:0012725)2.84643602
43Vertebral fusion (HP:0002948)2.84487923
44Failure to thrive in infancy (HP:0001531)2.81537611
45Generalized aminoaciduria (HP:0002909)2.71987388
46Hypokinesia (HP:0002375)2.62759991
47Abnormal hair whorl (HP:0010721)2.62105823
48Synostosis of carpal bones (HP:0005048)2.56726822
49Albinism (HP:0001022)2.56518265
50Supernumerary spleens (HP:0009799)2.49218684
51Abnormality of the tricuspid valve (HP:0001702)2.49116693
52Abnormality of glycolysis (HP:0004366)2.43447002
53Abnormality of the costochondral junction (HP:0000919)2.43134198
54Increased connective tissue (HP:0009025)2.42324579
55Recurrent corneal erosions (HP:0000495)2.38778107
56Ragged-red muscle fibers (HP:0003200)2.33472229
57Abnormality of the labia (HP:0000058)2.27875039
58Congenital stationary night blindness (HP:0007642)2.27513680
59Broad thumb (HP:0011304)2.25177364
60Broad toe (HP:0001837)2.22885803
61Renal Fanconi syndrome (HP:0001994)2.22170877
62Preaxial foot polydactyly (HP:0001841)2.14774623
63Ectopic anus (HP:0004397)2.10843793
64Wide anterior fontanel (HP:0000260)2.06576459
65Short middle phalanx of finger (HP:0005819)2.05961983
66Exocrine pancreatic insufficiency (HP:0001738)2.04205589
67Alveolar cell carcinoma (HP:0006519)2.03890185
68Myokymia (HP:0002411)10.4888684
69Broad finger (HP:0001500)1.99702554
70Abnormality of the clitoris (HP:0000056)1.98735785
71Abnormality of incisor morphology (HP:0011063)1.98464356
72Long eyelashes (HP:0000527)1.93848727
73Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91562800
74Broad phalanges of the hand (HP:0009768)1.90214319
75Male infertility (HP:0003251)1.84475641
76Abnormality of the odontoid process (HP:0003310)1.80017616
77Neoplasm of the tracheobronchial system (HP:0100552)1.79094324
78Absent speech (HP:0001344)1.78671557
79Broad phalanx (HP:0006009)1.74714518
80Hypoplastic nipples (HP:0002557)1.71510465
81Chorioretinal atrophy (HP:0000533)1.69839157
82Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.68650515
83Asplenia (HP:0001746)1.67749332
84Tubular atrophy (HP:0000092)1.66884619
85Carpal synostosis (HP:0009702)1.66382331
86Cervical subluxation (HP:0003308)1.66343852
87Macroglossia (HP:0000158)1.65134764
88Abnormal drinking behavior (HP:0030082)1.62212439
89Polydipsia (HP:0001959)1.62212439
90Broad long bones (HP:0005622)1.59418621
91Dysmetria (HP:0001310)1.58164559
92Flared iliac wings (HP:0002869)1.56703246
93Delayed cranial suture closure (HP:0000270)1.56579469
94Delayed gross motor development (HP:0002194)1.56474704
95High anterior hairline (HP:0009890)1.53653799
96Diminished movement (HP:0002374)1.52192980
97Postural instability (HP:0002172)1.51736976
98Synostosis involving bones of the hand (HP:0004278)1.47075555
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.46007913
100Abnormality of the middle phalanges of the hand (HP:0009833)1.43355614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.14568938
2NTRK33.17918509
3DYRK32.57120790
4MAP3K910.5605196
5PIK3CA1.95866699
6ARAF1.93555313
7LMTK21.88740287
8SIK31.70596196
9AKT31.67635464
10MINK11.60621302
11BCR1.55882466
12MAP2K71.53010455
13KIT1.42444797
14MAP3K41.34144059
15BRAF1.32932337
16DYRK1B1.28612317
17FGFR21.17283297
18NTRK21.11836888
19CSNK1G21.08878988
20TRIM281.06367012
21CSNK1G31.05516979
22EPHA41.05073927
23MAP3K131.04984122
24MAP3K61.01743169
25ACVR1B0.96851709
26CSNK1A1L0.93505526
27DAPK30.88908675
28LIMK10.88120586
29IRAK20.84676476
30DAPK20.83657871
31DYRK20.80816481
32MAPK120.77076631
33CSNK1G10.72885895
34BMPR20.70651547
35DDR20.68932566
36CDK140.67061634
37SIK20.62815903
38DYRK1A0.62070303
39CDK50.58017398
40PHKG10.57181081
41PHKG20.57181081
42TAOK10.56127457
43IRAK30.55632700
44AKT20.53546052
45PIM20.52247430
46YES10.51783510
47STK160.50629161
48SGK20.49632222
49FRK0.48871112
50RPS6KA20.47615682
51GRK10.45724623
52MAP2K40.45678357
53ROCK20.44824480
54STK110.44673474
55BMPR1B0.43422187
56SGK2230.41856187
57SGK4940.41856187
58STK380.41652250
59PRKCH0.41051899
60PRKCD0.38859827
61CDK180.38502434
62MET0.38105429
63PRKCG0.38029762
64MAPK90.37377593
65PRKD20.37124004
66CSNK1D0.37007914
67MAP3K50.35067736
68ERBB20.34583492
69CDK150.34249770
70PAK10.34146183
71MAPK130.34063989
72PRKG10.33109894
73CDK30.32866419
74TESK20.32104046
75CDK80.31741287
76LYN0.31383476
77IKBKB0.31230124
78MOS0.31207402
79STK390.29842288
80PAK30.29729068
81BCKDK0.28955070
82OXSR10.28898909
83WNK30.28725527
84MAPK110.28244617
85CDK11A0.28117705
86PKN10.27989402
87MAPK80.27857061
88MAPK40.26353342
89PRKACA0.25551310
90PRKCZ0.25312006
91FYN0.25129846
92TNIK0.24784816
93IRAK40.22679343
94SGK30.21362914
95SYK0.21343397
96PRKCE0.21079323
97CSK0.20943878
98CAMK2D0.20914774
99CAMK2A0.19905394
100FGFR10.19425399

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.86294172
2Long-term depression_Homo sapiens_hsa047303.97300086
3Parkinsons disease_Homo sapiens_hsa050123.61758640
4Oxidative phosphorylation_Homo sapiens_hsa001903.17205716
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60736257
6Phototransduction_Homo sapiens_hsa047442.13812223
7Tryptophan metabolism_Homo sapiens_hsa003802.08091094
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.07004478
9Huntingtons disease_Homo sapiens_hsa050162.03767820
10Alzheimers disease_Homo sapiens_hsa050102.01716604
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75766349
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64997909
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.63684079
14Notch signaling pathway_Homo sapiens_hsa043301.57676652
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.49729177
16Vibrio cholerae infection_Homo sapiens_hsa051101.45872507
17Rheumatoid arthritis_Homo sapiens_hsa053231.40955802
18Asthma_Homo sapiens_hsa053101.39102313
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37317998
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32949246
21Cardiac muscle contraction_Homo sapiens_hsa042601.31569803
22Butanoate metabolism_Homo sapiens_hsa006501.30458659
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25757208
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25097976
25Collecting duct acid secretion_Homo sapiens_hsa049661.22942096
26Synaptic vesicle cycle_Homo sapiens_hsa047211.19367389
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17168254
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15596317
29Shigellosis_Homo sapiens_hsa051311.14848980
30Morphine addiction_Homo sapiens_hsa050321.13677704
31beta-Alanine metabolism_Homo sapiens_hsa004101.08965803
32Alcoholism_Homo sapiens_hsa050341.08884995
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06258538
34Ether lipid metabolism_Homo sapiens_hsa005651.06235795
35Lysine degradation_Homo sapiens_hsa003101.05015721
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02530654
37Autoimmune thyroid disease_Homo sapiens_hsa053201.01061906
38Caffeine metabolism_Homo sapiens_hsa002321.00769355
39Fatty acid elongation_Homo sapiens_hsa000620.98457288
40Chemical carcinogenesis_Homo sapiens_hsa052040.97895711
41Nicotine addiction_Homo sapiens_hsa050330.97325498
42Protein export_Homo sapiens_hsa030600.97215507
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93933740
44Galactose metabolism_Homo sapiens_hsa000520.92848312
45Histidine metabolism_Homo sapiens_hsa003400.92252762
46Inositol phosphate metabolism_Homo sapiens_hsa005620.90840290
47Graft-versus-host disease_Homo sapiens_hsa053320.88507246
48Linoleic acid metabolism_Homo sapiens_hsa005910.88204320
49Wnt signaling pathway_Homo sapiens_hsa043100.88015437
50Allograft rejection_Homo sapiens_hsa053300.87565580
51African trypanosomiasis_Homo sapiens_hsa051430.86232732
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83576353
53Primary immunodeficiency_Homo sapiens_hsa053400.82943100
54Hippo signaling pathway_Homo sapiens_hsa043900.80995665
55Ribosome_Homo sapiens_hsa030100.80158538
56Taste transduction_Homo sapiens_hsa047420.80108688
57Phagosome_Homo sapiens_hsa041450.77356628
58Serotonergic synapse_Homo sapiens_hsa047260.76522022
59Sphingolipid metabolism_Homo sapiens_hsa006000.72847089
60B cell receptor signaling pathway_Homo sapiens_hsa046620.70543243
61Olfactory transduction_Homo sapiens_hsa047400.66743501
62Insulin secretion_Homo sapiens_hsa049110.66706424
63Regulation of autophagy_Homo sapiens_hsa041400.65735873
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65649672
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64638487
66Endocytosis_Homo sapiens_hsa041440.63670418
67Malaria_Homo sapiens_hsa051440.61425020
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59797342
69Salmonella infection_Homo sapiens_hsa051320.59285066
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58319304
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57543696
72Tight junction_Homo sapiens_hsa045300.56138301
73Lysosome_Homo sapiens_hsa041420.53238757
74Sulfur relay system_Homo sapiens_hsa041220.52723532
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49117829
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45368602
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44891578
78Other glycan degradation_Homo sapiens_hsa005110.44527064
79Dopaminergic synapse_Homo sapiens_hsa047280.43639018
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42583536
81Gap junction_Homo sapiens_hsa045400.41331340
82Selenocompound metabolism_Homo sapiens_hsa004500.40468609
83GABAergic synapse_Homo sapiens_hsa047270.39502850
84Glycerolipid metabolism_Homo sapiens_hsa005610.39042263
85Peroxisome_Homo sapiens_hsa041460.38295210
86Dorso-ventral axis formation_Homo sapiens_hsa043200.37139737
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37061674
88Tuberculosis_Homo sapiens_hsa051520.36832028
89Staphylococcus aureus infection_Homo sapiens_hsa051500.36049200
90Type I diabetes mellitus_Homo sapiens_hsa049400.35295873
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.34654736
92Cholinergic synapse_Homo sapiens_hsa047250.31669456
93Starch and sucrose metabolism_Homo sapiens_hsa005000.31317335
94Viral myocarditis_Homo sapiens_hsa054160.30568988
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29365056
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.29198838
97Axon guidance_Homo sapiens_hsa043600.28544983
98Basal cell carcinoma_Homo sapiens_hsa052170.28053805
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26890373
100Metabolic pathways_Homo sapiens_hsa011000.26268086

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