ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maintenance of gastrointestinal epithelium (GO:0030277)	9.07412880
2	response to vitamin A (GO:0033189)	8.96843115
3	epithelial structure maintenance (GO:0010669)	7.08570069
4	potassium ion export (GO:0071435)	6.91687225
5	cellular response to epidermal growth factor stimulus (GO:0071364)	6.90119499
6	response to epidermal growth factor (GO:0070849)	6.30808930
7	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	5.33486870
8	membrane repolarization (GO:0086009)	5.24632203
9	nephron tubule morphogenesis (GO:0072078)	5.20447289
10	nephron epithelium morphogenesis (GO:0072088)	5.20447289
11	O-glycan processing (GO:0016266)	4.93187779
12	membrane repolarization during action potential (GO:0086011)	4.91169342
13	meiotic chromosome segregation (GO:0045132)	4.88950875
14	DNA methylation involved in gamete generation (GO:0043046)	4.87743909
15	creatine metabolic process (GO:0006600)	4.47545378
16	DNA replication initiation (GO:0006270)	4.28266514
17	regulation of ARF GTPase activity (GO:0032312)	4.25709422
18	DNA replication checkpoint (GO:0000076)	4.09210915
19	regulation of translational fidelity (GO:0006450)	4.06058085
20	regulation of histone H3-K4 methylation (GO:0051569)	4.04442229
21	rRNA catabolic process (GO:0016075)	4.03493480
22	piRNA metabolic process (GO:0034587)	4.00345719
23	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	4.00054923
24	synapsis (GO:0007129)	3.99257092
25	cellular response to glucocorticoid stimulus (GO:0071385)	3.99120561
26	nuclear pore complex assembly (GO:0051292)	3.96599224
27	negative regulation of digestive system process (GO:0060457)	3.88233318
28	renal tubule morphogenesis (GO:0061333)	3.63135836
29	C21-steroid hormone biosynthetic process (GO:0006700)	3.61941585
30	cellular response to corticosteroid stimulus (GO:0071384)	3.60231832
31	regulation of RNA export from nucleus (GO:0046831)	3.56371205
32	positive regulation of histone deacetylation (GO:0031065)	3.42427975
33	resolution of meiotic recombination intermediates (GO:0000712)	3.40234300
34	protein O-linked glycosylation (GO:0006493)	3.37656699
35	chromatin assembly (GO:0031497)	3.36579322
36	nuclear pore organization (GO:0006999)	3.36121785
37	DNA damage induced protein phosphorylation (GO:0006975)	3.33178680
38	positive regulation by host of viral transcription (GO:0043923)	3.31620309
39	male meiosis (GO:0007140)	3.25150188
40	mitotic sister chromatid segregation (GO:0000070)	3.23804980
41	hindbrain development (GO:0030902)	3.21716096
42	mitotic nuclear envelope disassembly (GO:0007077)	3.18379847
43	vocalization behavior (GO:0071625)	3.10144380
44	regulation of histone methylation (GO:0031060)	3.07142629
45	DNA unwinding involved in DNA replication (GO:0006268)	3.06444202
46	trivalent inorganic anion homeostasis (GO:0072506)	3.05800717
47	phosphate ion homeostasis (GO:0055062)	3.05800717
48	vitamin A metabolic process (GO:0006776)	3.05356982
49	chromosome organization involved in meiosis (GO:0070192)	3.02598684
50	regulation of histone H3-K27 methylation (GO:0061085)	3.01414167
51	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.00140498
52	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.00140498
53	formation of translation preinitiation complex (GO:0001731)	2.99164566
54	sister chromatid segregation (GO:0000819)	2.97639774
55	intra-S DNA damage checkpoint (GO:0031573)	2.97290009
56	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.95671024
57	striated muscle atrophy (GO:0014891)	2.92718584
58	regulation of nucleobase-containing compound transport (GO:0032239)	2.92528790
59	negative regulation of histone methylation (GO:0031061)	2.89882828
60	DNA topological change (GO:0006265)	2.88823131
61	glucocorticoid biosynthetic process (GO:0006704)	2.88176498
62	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.87697078
63	urinary tract smooth muscle contraction (GO:0014848)	2.87684460
64	DNA methylation (GO:0006306)	2.87185253
65	DNA alkylation (GO:0006305)	2.87185253
66	chromosome condensation (GO:0030261)	2.86693928
67	nuclear envelope disassembly (GO:0051081)	2.86304757
68	membrane disassembly (GO:0030397)	2.86304757
69	protein-DNA complex disassembly (GO:0032986)	2.85330090
70	nucleosome disassembly (GO:0006337)	2.85330090
71	histone H3-K9 demethylation (GO:0033169)	2.84832409
72	DNA strand renaturation (GO:0000733)	2.83576568
73	mismatch repair (GO:0006298)	2.82865658
74	motile cilium assembly (GO:0044458)	2.82831646
75	cellular response to retinoic acid (GO:0071300)	2.82459131
76	digestive system process (GO:0022600)	2.80469984
77	positive regulation of gene expression, epigenetic (GO:0045815)	2.79651781
78	DNA synthesis involved in DNA repair (GO:0000731)	2.78294935
79	replicative senescence (GO:0090399)	2.76812526
80	membrane depolarization during action potential (GO:0086010)	2.75384171
81	growth hormone secretion (GO:0030252)	2.74017320
82	regulation of histone deacetylation (GO:0031063)	2.72230292
83	protein targeting to Golgi (GO:0000042)	2.69792945
84	muscle atrophy (GO:0014889)	2.69351063
85	cellular anion homeostasis (GO:0030002)	2.69058185
86	homocysteine metabolic process (GO:0050667)	2.68885994
87	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.68534876
88	cysteine metabolic process (GO:0006534)	2.67464104
89	skeletal muscle adaptation (GO:0043501)	2.66700894
90	glucocorticoid receptor signaling pathway (GO:0042921)	2.64307934
91	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.63214571
92	neural tube development (GO:0021915)	2.60610239
93	DNA packaging (GO:0006323)	2.60353307
94	epithelial cell fate commitment (GO:0072148)	2.59491376
95	pore complex assembly (GO:0046931)	2.59264412
96	DNA conformation change (GO:0071103)	2.59181338
97	cilium or flagellum-dependent cell motility (GO:0001539)	2.59021959
98	proline biosynthetic process (GO:0006561)	2.57779259
99	establishment of protein localization to Golgi (GO:0072600)	2.56292968
100	regulation of G0 to G1 transition (GO:0070316)	11.8297171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.33506772
2	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	6.25014036
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.29703580
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.45136576
5	DROSHA_22980978_ChIP-Seq_HELA_Human	3.20434354
6	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.75337347
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.73437017
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.49560415
9	GATA1_19941826_ChIP-Seq_K562_Human	2.25529619
10	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.24890701
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.15660357
12	NCOR1_26117541_ChIP-Seq_K562_Human	2.06719237
13	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.02627988
14	E2F1_20622854_ChIP-Seq_HELA_Human	1.92614001
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.88082777
16	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.85663338
17	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.84566634
18	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.80250307
19	VDR_22108803_ChIP-Seq_LS180_Human	1.78536461
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.76277989
21	P68_20966046_ChIP-Seq_HELA_Human	1.72919870
22	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.72765801
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71592963
24	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.71516869
25	SPI1_23127762_ChIP-Seq_K562_Human	1.59666521
26	PHF8_20622854_ChIP-Seq_HELA_Human	1.59441862
27	SMC4_20622854_ChIP-Seq_HELA_Human	1.58867184
28	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.49679120
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.49148565
30	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45192604
31	NFYA_21822215_ChIP-Seq_K562_Human	1.44897281
32	CTCF_27219007_Chip-Seq_Bcells_Human	1.44026107
33	GATA2_19941826_ChIP-Seq_K562_Human	1.43525344
34	CTCF_20526341_ChIP-Seq_ESCs_Human	1.39064123
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.38722176
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38625301
37	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.38292203
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37915371
39	PHF8_20622853_ChIP-Seq_HELA_Human	1.37756478
40	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.36908493
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.34893186
42	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.32962860
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.32962315
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.32856732
45	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.32325084
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.31833572
47	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.30299775
48	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.30207046
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.28573588
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26759784
51	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.26663824
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.25709923
53	RBPJ_21746931_ChIP-Seq_IB4_Human	1.25628655
54	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25406935
55	BCOR_27268052_Chip-Seq_Bcells_Human	1.23972211
56	NFYB_21822215_ChIP-Seq_K562_Human	1.23859387
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20792763
58	ETV1_20927104_ChIP-Seq_GIST48_Human	1.19631143
59	SA1_27219007_Chip-Seq_Bcells_Human	1.19029492
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18977686
61	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.15040396
62	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14948317
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.11190200
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10824436
65	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.09363420
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.09349262
67	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09241543
68	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.08902894
69	OCT4_19829295_ChIP-Seq_ESCs_Human	1.05824096
70	ERA_21632823_ChIP-Seq_H3396_Human	1.05295491
71	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05253810
72	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.05162202
73	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04570243
74	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03539656
75	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.03537610
76	RACK7_27058665_Chip-Seq_MCF-7_Human	1.02939040
77	RAC3_21632823_ChIP-Seq_H3396_Human	1.02291552
78	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.02218004
79	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.02134947
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02048895
81	TBL1_22424771_ChIP-Seq_293T_Human	1.01098448
82	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00114291
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98869869
84	P300_27268052_Chip-Seq_Bcells_Human	0.97675287
85	GBX2_23144817_ChIP-Seq_PC3_Human	0.96898865
86	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.96827407
87	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96350972
88	CREB1_26743006_Chip-Seq_LNCaP_Human	0.94946531
89	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.94129249
90	LXR_22292898_ChIP-Seq_THP-1_Human	0.93907107
91	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.93743979
92	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.91596136
93	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.90185806
94	GATA6_25053715_ChIP-Seq_YYC3_Human	0.88405752
95	MYC_18940864_ChIP-ChIP_HL60_Human	0.88005861
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86365595
97	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.85403856
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.85045860
99	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.84495504
100	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.84164788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.90581147
2	MP0004043_abnormal_pH_regulation	3.49747596
3	MP0008995_early_reproductive_senescence	3.29040204
4	MP0000566_synostosis	3.20873615
5	MP0003879_abnormal_hair_cell	3.16336814
6	MP0000579_abnormal_nail_morphology	2.92818237
7	MP0003705_abnormal_hypodermis_morpholog	2.91372723
8	MP0004145_abnormal_muscle_electrophysio	2.90642732
9	MP0002249_abnormal_larynx_morphology	2.87235498
10	MP0004147_increased_porphyrin_level	2.81581575
11	MP0000465_gastrointestinal_hemorrhage	2.67350442
12	MP0010094_abnormal_chromosome_stability	2.55323630
13	MP0005171_absent_coat_pigmentation	2.51726384
14	MP0008058_abnormal_DNA_repair	2.43597831
15	MP0003111_abnormal_nucleus_morphology	2.39535943
16	MP0005083_abnormal_biliary_tract	2.27034297
17	MP0003693_abnormal_embryo_hatching	2.19396824
18	MP0001661_extended_life_span	2.16368699
19	MP0000678_abnormal_parathyroid_gland	2.15052883
20	MP0003786_premature_aging	2.10441017
21	MP0001666_abnormal_nutrient_absorption	1.76708704
22	MP0009697_abnormal_copulation	1.76225438
23	MP0002210_abnormal_sex_determination	1.68451791
24	MP0005275_abnormal_skin_tensile	1.60113182
25	MP0005220_abnormal_exocrine_pancreas	1.58274402
26	MP0008438_abnormal_cutaneous_collagen	1.54545338
27	MP0001664_abnormal_digestion	1.42048755
28	MP0000647_abnormal_sebaceous_gland	1.39696329
29	MP0003959_abnormal_lean_body	1.39606768
30	MP0003698_abnormal_male_reproductive	1.37256764
31	MP0004957_abnormal_blastocyst_morpholog	1.36982395
32	MP0001485_abnormal_pinna_reflex	1.35622142
33	MP0001929_abnormal_gametogenesis	1.34747042
34	MP0008932_abnormal_embryonic_tissue	1.30676905
35	MP0010030_abnormal_orbit_morphology	1.26110640
36	MP0005503_abnormal_tendon_morphology	1.24007206
37	MP0001663_abnormal_digestive_system	1.23990542
38	MP0002269_muscular_atrophy	1.23731502
39	MP0009840_abnormal_foam_cell	1.21725833
40	MP0005377_hearing/vestibular/ear_phenot	1.21705421
41	MP0003878_abnormal_ear_physiology	1.21705421
42	MP0002653_abnormal_ependyma_morphology	1.20933548
43	MP0000026_abnormal_inner_ear	1.20822433
44	MP0001765_abnormal_ion_homeostasis	1.19403016
45	MP0000749_muscle_degeneration	1.19269206
46	MP0008007_abnormal_cellular_replicative	1.16102559
47	MP0004233_abnormal_muscle_weight	1.15126269
48	MP0004019_abnormal_vitamin_homeostasis	1.14794095
49	MP0000427_abnormal_hair_cycle	1.14215680
50	MP0009278_abnormal_bone_marrow	1.13604789
51	MP0005381_digestive/alimentary_phenotyp	1.12614701
52	MP0002138_abnormal_hepatobiliary_system	1.11240228
53	MP0001730_embryonic_growth_arrest	1.10965492
54	MP0001243_abnormal_dermal_layer	1.08091113
55	MP0008877_abnormal_DNA_methylation	1.02925383
56	MP0010307_abnormal_tumor_latency	1.00459077
57	MP0003866_abnormal_defecation	1.00304592
58	MP0003385_abnormal_body_wall	0.98616143
59	MP0000747_muscle_weakness	0.95871556
60	MP0004742_abnormal_vestibular_system	0.95186804
61	MP0002928_abnormal_bile_duct	0.95181150
62	MP0001145_abnormal_male_reproductive	0.94068155
63	MP0005076_abnormal_cell_differentiation	0.92705051
64	MP0001963_abnormal_hearing_physiology	0.91045592
65	MP0002160_abnormal_reproductive_system	0.90763095
66	MP0003943_abnormal_hepatobiliary_system	0.89810563
67	MP0002282_abnormal_trachea_morphology	0.89078034
68	MP0000653_abnormal_sex_gland	0.88554482
69	MP0002095_abnormal_skin_pigmentation	0.88010060
70	MP0003077_abnormal_cell_cycle	0.87153945
71	MP0003045_fibrosis	0.83670530
72	MP0003950_abnormal_plasma_membrane	0.82540033
73	MP0000350_abnormal_cell_proliferation	0.82067968
74	MP0000428_abnormal_craniofacial_morphol	0.81193615
75	MP0000631_abnormal_neuroendocrine_gland	0.78449356
76	MP0005410_abnormal_fertilization	0.77662802
77	MP0002161_abnormal_fertility/fecundity	0.76789332
78	MP0002084_abnormal_developmental_patter	0.76323303
79	MP0002085_abnormal_embryonic_tissue	0.73689260
80	MP0003937_abnormal_limbs/digits/tail_de	0.73637220
81	MP0002822_catalepsy	0.72629872
82	MP0005636_abnormal_mineral_homeostasis	0.72541346
83	MP0001672_abnormal_embryogenesis/_devel	0.72302230
84	MP0005380_embryogenesis_phenotype	0.72302230
85	MP0003656_abnormal_erythrocyte_physiolo	0.71580918
86	MP0009703_decreased_birth_body	0.71223241
87	MP0000049_abnormal_middle_ear	0.70520588
88	MP0009672_abnormal_birth_weight	0.70329848
89	MP0003699_abnormal_female_reproductive	0.69228257
90	MP0003984_embryonic_growth_retardation	0.69072634
91	MP0003646_muscle_fatigue	0.67113397
92	MP0003718_maternal_effect	0.66895848
93	MP0005332_abnormal_amino_acid	0.65999390
94	MP0001270_distended_abdomen	0.65982229
95	MP0003935_abnormal_craniofacial_develop	0.65275432
96	MP0002088_abnormal_embryonic_growth/wei	0.64467242
97	MP0009250_abnormal_appendicular_skeleto	0.63703288
98	MP0002080_prenatal_lethality	0.63448146
99	MP0002111_abnormal_tail_morphology	0.63273536
100	MP0002114_abnormal_axial_skeleton	0.62008402

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	4.36282378
2	Thin bony cortex (HP:0002753)	4.15080412
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.12409017
4	Reticulocytosis (HP:0001923)	3.88184694
5	Chromsome breakage (HP:0040012)	3.86838556
6	Mask-like facies (HP:0000298)	3.84559815
7	Abnormality of dentin (HP:0010299)	3.83057162
8	Enlarged epiphyses (HP:0010580)	3.82473699
9	Abnormality of reticulocytes (HP:0004312)	3.73075121
10	Delayed epiphyseal ossification (HP:0002663)	3.70309168
11	Duplicated collecting system (HP:0000081)	3.68077543
12	Abnormal gallbladder physiology (HP:0012438)	3.54492743
13	Cholecystitis (HP:0001082)	3.54492743
14	Abnormality of DNA repair (HP:0003254)	3.49249015
15	Abnormal hair laboratory examination (HP:0003328)	3.48548594
16	Birth length less than 3rd percentile (HP:0003561)	3.45140848
17	Reticulocytopenia (HP:0001896)	3.41177133
18	Truncus arteriosus (HP:0001660)	3.20766956
19	Ankyloglossia (HP:0010296)	3.17935218
20	Hyperacusis (HP:0010780)	3.15127006
21	Abnormality of cochlea (HP:0000375)	3.14263186
22	Abnormality of the renal collecting system (HP:0004742)	3.13244316
23	Flat cornea (HP:0007720)	3.10762277
24	Palpebral edema (HP:0100540)	3.06525608
25	Hypophosphatemic rickets (HP:0004912)	3.02257603
26	Hyperkalemia (HP:0002153)	3.01738994
27	Distal upper limb amyotrophy (HP:0007149)	2.96967959
28	Upper limb amyotrophy (HP:0009129)	2.96967959
29	Hemorrhage of the eye (HP:0011885)	2.85113504
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.84440884
31	Urethral obstruction (HP:0000796)	2.83663537
32	Ureteral duplication (HP:0000073)	2.78639624
33	Abnormality of the carotid arteries (HP:0005344)	2.78195765
34	Ectopic kidney (HP:0000086)	2.67119069
35	Abnormality of chloride homeostasis (HP:0011422)	2.65062672
36	Duplication of thumb phalanx (HP:0009942)	2.64852859
37	Tibial bowing (HP:0002982)	2.60873556
38	Congenital sensorineural hearing impairment (HP:0008527)	2.51226658
39	Insomnia (HP:0100785)	2.38285413
40	Upper limb muscle weakness (HP:0003484)	2.37072048
41	Premature skin wrinkling (HP:0100678)	2.36678453
42	Distal lower limb amyotrophy (HP:0008944)	2.35374941
43	Abnormal number of erythroid precursors (HP:0012131)	2.35295804
44	Concave nail (HP:0001598)	2.35052555
45	Partial agenesis of the corpus callosum (HP:0001338)	2.33891284
46	Bony spicule pigmentary retinopathy (HP:0007737)	2.31676414
47	Abnormality of the costochondral junction (HP:0000919)	2.27577146
48	Abnormal trabecular bone morphology (HP:0100671)	2.27452500
49	Abnormality of the preputium (HP:0100587)	2.26534277
50	Tracheomalacia (HP:0002779)	2.21454614
51	Increased connective tissue (HP:0009025)	2.21212898
52	Bowel incontinence (HP:0002607)	2.17518665
53	Abnormality of pyrimidine metabolism (HP:0004353)	2.16697086
54	Progressive cerebellar ataxia (HP:0002073)	2.14181772
55	Hand muscle atrophy (HP:0009130)	2.12671833
56	Abnormality of the diencephalon (HP:0010662)	2.11535929
57	Morphological abnormality of the inner ear (HP:0011390)	2.10967840
58	Bladder diverticulum (HP:0000015)	2.10794023
59	Atelectasis (HP:0100750)	2.10489534
60	Nonimmune hydrops fetalis (HP:0001790)	2.09988909
61	Abnormal large intestine physiology (HP:0012700)	2.07281565
62	Natal tooth (HP:0000695)	2.06784936
63	Horizontal nystagmus (HP:0000666)	2.06568579
64	Self-mutilation (HP:0000742)	2.05943593
65	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04869580
66	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.02946770
67	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.00600261
68	Renovascular hypertension (HP:0100817)	2.00353265
69	Cystic liver disease (HP:0006706)	2.00107433
70	Tinnitus (HP:0000360)	2.00032350
71	Mildly elevated creatine phosphokinase (HP:0008180)	1.96872489
72	Meckel diverticulum (HP:0002245)	1.96561466
73	Abnormality of the fingertips (HP:0001211)	1.93371703
74	Patent foramen ovale (HP:0001655)	1.92989375
75	Duodenal stenosis (HP:0100867)	1.90958700
76	Small intestinal stenosis (HP:0012848)	1.90958700
77	Abnormality of the ileum (HP:0001549)	1.90028095
78	Abnormality of oral frenula (HP:0000190)	1.89396421
79	Polycystic kidney dysplasia (HP:0000113)	1.88233670
80	Elfin facies (HP:0004428)	1.86582145
81	Abnormality of chromosome stability (HP:0003220)	1.85839272
82	Abnormality of the aortic arch (HP:0012303)	1.84940578
83	Bronchomalacia (HP:0002780)	1.84131611
84	Widely patent fontanelles and sutures (HP:0004492)	1.83950113
85	Poikilocytosis (HP:0004447)	1.83047825
86	Disproportionate tall stature (HP:0001519)	1.82610568
87	Renal duplication (HP:0000075)	1.81914632
88	Short nail (HP:0001799)	1.81337691
89	Rib fusion (HP:0000902)	1.80470089
90	Long eyelashes (HP:0000527)	1.79121799
91	Hyperthyroidism (HP:0000836)	1.78428734
92	Hypoplastic iliac wings (HP:0002866)	1.76965558
93	Diaphragmatic weakness (HP:0009113)	1.76476389
94	Male infertility (HP:0003251)	1.76380486
95	Spinal muscular atrophy (HP:0007269)	1.76366978
96	Thin ribs (HP:0000883)	1.75512297
97	Sandal gap (HP:0001852)	1.74710247
98	High pitched voice (HP:0001620)	1.74588874
99	Bilateral sensorineural hearing impairment (HP:0008619)	1.74518201
100	Broad face (HP:0000283)	1.73565037

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	7.30293115
2	MST1R	5.47633220
3	NME1	4.79622054
4	PNCK	4.05491133
5	CDK12	3.36601328
6	WNK1	3.15158473
7	SMG1	2.54218279
8	MAPK15	2.26632395
9	TSSK6	2.16968637
10	TTK	2.14593479
11	MET	2.12215981
12	WEE1	1.98805925
13	NEK2	1.98585311
14	MUSK	1.97588018
15	EEF2K	1.75820142
16	ICK	1.66227484
17	INSRR	1.61763972
18	TNIK	1.55523219
19	VRK2	1.53369942
20	MAPKAPK5	1.51709246
21	TRPM7	1.46770100
22	TRIB3	1.43363856
23	CLK1	1.39492789
24	TAF1	1.38376220
25	CASK	1.34607624
26	SIK2	1.18868120
27	KSR2	1.18187985
28	CDC7	1.06896590
29	RIPK4	1.06574665
30	MAP3K2	1.02868347
31	ZAK	1.00200646
32	MAP3K7	0.99385100
33	EIF2AK1	0.98347173
34	BRD4	0.96634019
35	MAP2K6	0.96515636
36	PRKG2	0.92177898
37	ATR	0.84278528
38	MAP3K8	0.83870956
39	CHEK2	0.83515085
40	ACVR1B	0.80960331
41	CDK9	0.80513766
42	MTOR	0.79623445
43	VRK1	0.79031133
44	NTRK3	0.74763697
45	ERN1	0.71359045
46	PLK4	0.65073990
47	CAMK1G	0.64408784
48	CHEK1	0.62917812
49	KSR1	0.60857767
50	MAPKAPK3	0.60366498
51	RET	0.57660979
52	PASK	0.56479936
53	STK3	0.54177231
54	NTRK1	0.54015991
55	MAP2K2	0.52878059
56	CAMK1D	0.50559071
57	NUAK1	0.50437305
58	PAK2	0.49579448
59	MELK	0.47502178
60	CDK1	0.46850932
61	PLK1	0.45160151
62	CDK2	0.44142819
63	CDK3	0.41433158
64	SGK1	0.41098181
65	ATM	0.39921940
66	BRAF	0.39605122
67	RPS6KB2	0.38675853
68	CDK7	0.38551818
69	PTK6	0.38535943
70	ERBB2	0.38164748
71	AKT1	0.38062347
72	BLK	0.37844888
73	DDR2	0.37743272
74	IRAK3	0.37659848
75	CDK8	0.36482119
76	SIK1	0.35106390
77	STK39	0.34824783
78	CCNB1	0.32706737
79	HIPK2	0.32332474
80	BMX	0.32262889
81	DYRK3	0.32208969
82	MAP2K1	0.31747334
83	RAF1	0.31605433
84	PRKAA1	0.29620437
85	TLK1	0.28075773
86	PRKAA2	0.26733592
87	PLK3	0.26676904
88	CSNK1E	0.26650426
89	PRKDC	0.25670899
90	AKT2	0.23511641
91	MAP3K4	0.23326155
92	RPS6KA2	0.22875431
93	CDK11A	0.22042605
94	GSK3B	0.21707955
95	PIK3CG	0.21488830
96	LRRK2	0.20953765
97	MAPK14	0.20829005
98	MAPK1	0.18114815
99	MKNK1	0.18060761
100	TYRO3	0.17826108

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.59418262
2	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	3.52941760
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.94925204
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.86439278
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.62158038
6	DNA replication_Homo sapiens_hsa03030	2.61771156
7	Homologous recombination_Homo sapiens_hsa03440	2.61472033
8	One carbon pool by folate_Homo sapiens_hsa00670	2.54186242
9	Mismatch repair_Homo sapiens_hsa03430	2.35424963
10	Oocyte meiosis_Homo sapiens_hsa04114	2.15991623
11	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.08932491
12	RNA transport_Homo sapiens_hsa03013	1.94313725
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93939477
14	ABC transporters_Homo sapiens_hsa02010	1.92956759
15	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.83406483
16	Olfactory transduction_Homo sapiens_hsa04740	1.82473122
17	Lysine degradation_Homo sapiens_hsa00310	1.81639049
18	Basal transcription factors_Homo sapiens_hsa03022	1.57637843
19	Type II diabetes mellitus_Homo sapiens_hsa04930	1.51624451
20	Salivary secretion_Homo sapiens_hsa04970	1.51257885
21	Spliceosome_Homo sapiens_hsa03040	1.51094161
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.44141140
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.36608295
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33151930
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26556213
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.23713308
27	Taste transduction_Homo sapiens_hsa04742	1.20236582
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.18966297
29	Cell cycle_Homo sapiens_hsa04110	1.18726691
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14700484
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.13486242
32	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.08428073
33	Sulfur relay system_Homo sapiens_hsa04122	0.99313271
34	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98291582
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.98244164
36	Base excision repair_Homo sapiens_hsa03410	0.96512918
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92440605
38	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.92149833
39	Thyroid cancer_Homo sapiens_hsa05216	0.92083820
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91145897
41	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.90893108
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90256282
43	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89738733
44	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.87094862
45	Amoebiasis_Homo sapiens_hsa05146	0.86939485
46	Protein digestion and absorption_Homo sapiens_hsa04974	0.86608124
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.85756252
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.85298695
49	Butanoate metabolism_Homo sapiens_hsa00650	0.85297369
50	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.80322556
51	Insulin secretion_Homo sapiens_hsa04911	0.80309815
52	Carbon metabolism_Homo sapiens_hsa01200	0.79867609
53	Nicotine addiction_Homo sapiens_hsa05033	0.78557273
54	Notch signaling pathway_Homo sapiens_hsa04330	0.76310324
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75857543
56	ECM-receptor interaction_Homo sapiens_hsa04512	0.75615150
57	VEGF signaling pathway_Homo sapiens_hsa04370	0.73237443
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.72587125
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72141053
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.66984429
61	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.66701412
62	Choline metabolism in cancer_Homo sapiens_hsa05231	0.65949180
63	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.63667784
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.63286030
65	mTOR signaling pathway_Homo sapiens_hsa04150	0.62416757
66	ErbB signaling pathway_Homo sapiens_hsa04012	0.59946458
67	Purine metabolism_Homo sapiens_hsa00230	0.58974092
68	Ribosome_Homo sapiens_hsa03010	0.58612532
69	Propanoate metabolism_Homo sapiens_hsa00640	0.58208174
70	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.57642640
71	Circadian entrainment_Homo sapiens_hsa04713	0.57239870
72	Arginine biosynthesis_Homo sapiens_hsa00220	0.57083247
73	Long-term depression_Homo sapiens_hsa04730	0.56496384
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50444437
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.49533082
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48913800
77	Bile secretion_Homo sapiens_hsa04976	0.46156449
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45409359
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44899191
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43992257
81	Cholinergic synapse_Homo sapiens_hsa04725	0.42950370
82	Galactose metabolism_Homo sapiens_hsa00052	0.42820551
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.41672554
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.41601883
85	GnRH signaling pathway_Homo sapiens_hsa04912	0.40875888
86	Acute myeloid leukemia_Homo sapiens_hsa05221	0.38343791
87	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37633706
88	Other glycan degradation_Homo sapiens_hsa00511	0.37424352
89	Cocaine addiction_Homo sapiens_hsa05030	0.37324328
90	Gap junction_Homo sapiens_hsa04540	0.36671489
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34104798
92	Melanogenesis_Homo sapiens_hsa04916	0.33957840
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32901779
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.32538030
95	Caffeine metabolism_Homo sapiens_hsa00232	0.32040353
96	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.31618909
97	Retinol metabolism_Homo sapiens_hsa00830	0.31489853
98	Prion diseases_Homo sapiens_hsa05020	0.31250485
99	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29111134
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.28903067

CT47A12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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