ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.91250647
2	nuclear pore organization (GO:0006999)	6.04552109
3	DNA replication checkpoint (GO:0000076)	5.89372150
4	regulation of translational fidelity (GO:0006450)	5.42060404
5	pore complex assembly (GO:0046931)	5.11259912
6	synapsis (GO:0007129)	5.09024823
7	resolution of meiotic recombination intermediates (GO:0000712)	5.01405410
8	diterpenoid biosynthetic process (GO:0016102)	4.90127281
9	protoporphyrinogen IX metabolic process (GO:0046501)	4.79016489
10	regulation of histone H3-K4 methylation (GO:0051569)	4.52090310
11	DNA topological change (GO:0006265)	4.51959482
12	terpenoid biosynthetic process (GO:0016114)	4.46871382
13	gas transport (GO:0015669)	4.45748447
14	mitotic nuclear envelope disassembly (GO:0007077)	4.44182291
15	formation of translation preinitiation complex (GO:0001731)	4.39820524
16	DNA unwinding involved in DNA replication (GO:0006268)	4.34405950
17	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.29148569
18	DNA replication initiation (GO:0006270)	4.22156594
19	vitamin A metabolic process (GO:0006776)	4.21672632
20	oxygen transport (GO:0015671)	4.17558110
21	tRNA aminoacylation for protein translation (GO:0006418)	4.15726046
22	homocysteine metabolic process (GO:0050667)	4.11815802
23	mitotic sister chromatid segregation (GO:0000070)	4.09367614
24	nuclear envelope disassembly (GO:0051081)	4.06095827
25	membrane disassembly (GO:0030397)	4.06095827
26	amino acid activation (GO:0043038)	4.03737991
27	tRNA aminoacylation (GO:0043039)	4.03737991
28	regulation of histone H3-K27 methylation (GO:0061085)	3.93747104
29	sister chromatid segregation (GO:0000819)	3.92679377
30	regulation of RNA export from nucleus (GO:0046831)	3.83974197
31	oxidative phosphorylation (GO:0006119)	3.80984974
32	meiotic chromosome segregation (GO:0045132)	3.80285521
33	DNA strand elongation involved in DNA replication (GO:0006271)	3.78568877
34	DNA strand elongation (GO:0022616)	3.66695479
35	purine nucleobase biosynthetic process (GO:0009113)	3.63743905
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.57246994
37	regulation of translational elongation (GO:0006448)	3.56309543
38	folic acid-containing compound biosynthetic process (GO:0009396)	3.50930274
39	erythrocyte maturation (GO:0043249)	3.44848857
40	telomere maintenance via semi-conservative replication (GO:0032201)	3.43358588
41	nucleobase biosynthetic process (GO:0046112)	3.40203180
42	mitotic chromosome condensation (GO:0007076)	3.39905048
43	DNA methylation involved in gamete generation (GO:0043046)	3.39532880
44	sensory perception of smell (GO:0007608)	3.35133343
45	IMP biosynthetic process (GO:0006188)	3.33989268
46	oxaloacetate metabolic process (GO:0006107)	3.33233159
47	microtubule depolymerization (GO:0007019)	3.30396355
48	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.30305596
49	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.27616483
50	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.18482122
51	regulation of histone methylation (GO:0031060)	3.17832686
52	kinetochore organization (GO:0051383)	3.16862905
53	chromosome segregation (GO:0007059)	3.16543516
54	ATP synthesis coupled proton transport (GO:0015986)	3.16012351
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.16012351
56	ribosomal large subunit biogenesis (GO:0042273)	3.15096729
57	intra-S DNA damage checkpoint (GO:0031573)	3.14610158
58	tetrahydrofolate metabolic process (GO:0046653)	3.14247131
59	negative regulation of erythrocyte differentiation (GO:0045647)	3.08879011
60	positive regulation of histone H3-K4 methylation (GO:0051571)	3.07876829
61	centriole replication (GO:0007099)	3.07342269
62	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.07150022
63	phosphorelay signal transduction system (GO:0000160)	3.06698948
64	creatine metabolic process (GO:0006600)	3.05375727
65	telomere maintenance via recombination (GO:0000722)	3.04792918
66	mitotic recombination (GO:0006312)	3.03143023
67	ribosomal small subunit assembly (GO:0000028)	3.02474250
68	proline biosynthetic process (GO:0006561)	3.01193958
69	ribosome biogenesis (GO:0042254)	2.99828788
70	isoprenoid biosynthetic process (GO:0008299)	2.99064223
71	viral mRNA export from host cell nucleus (GO:0046784)	2.96560474
72	regulation of nucleobase-containing compound transport (GO:0032239)	2.96524135
73	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.96468919
74	response to vitamin A (GO:0033189)	2.93468825
75	regulation of DNA damage checkpoint (GO:2000001)	2.92793942
76	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.90248191
77	kinetochore assembly (GO:0051382)	2.89057121
78	granulocyte differentiation (GO:0030851)	2.88484308
79	valine metabolic process (GO:0006573)	2.87527158
80	mitotic metaphase plate congression (GO:0007080)	2.87158472
81	ribonucleoprotein complex biogenesis (GO:0022613)	2.85605408
82	regulation of mitotic spindle organization (GO:0060236)	2.85498080
83	telomere maintenance via telomere lengthening (GO:0010833)	2.83886431
84	negative regulation of histone methylation (GO:0031061)	2.83080927
85	IMP metabolic process (GO:0046040)	2.80845594
86	regulation of gene expression by genetic imprinting (GO:0006349)	2.80609626
87	nuclear envelope organization (GO:0006998)	2.75811075
88	erythrocyte development (GO:0048821)	2.75522615
89	succinate metabolic process (GO:0006105)	2.74291659
90	proteasome assembly (GO:0043248)	2.73149295
91	DNA synthesis involved in DNA repair (GO:0000731)	2.72738007
92	tetrapyrrole biosynthetic process (GO:0033014)	2.72291487
93	maturation of SSU-rRNA (GO:0030490)	2.72268679
94	chromosome organization involved in meiosis (GO:0070192)	2.71275461
95	potassium ion export (GO:0071435)	2.71180554
96	mismatch repair (GO:0006298)	2.70743335
97	porphyrin-containing compound biosynthetic process (GO:0006779)	2.70384620
98	replication fork processing (GO:0031297)	2.70297075
99	protein localization to kinetochore (GO:0034501)	2.69724077
100	centriole assembly (GO:0098534)	2.67786282

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.51911101
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.97551076
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.77016063
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.35932523
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.33913683
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.31672083
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.18677681
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.16588129
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.96562753
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.93286652
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90283834
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88782925
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.71525460
14	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.66373420
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.52959010
16	NCOR1_26117541_ChIP-Seq_K562_Human	2.50597626
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.45217571
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.40507848
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40380710
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.31017591
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.24911270
22	GATA1_19941826_ChIP-Seq_K562_Human	2.17221912
23	TTF2_22483619_ChIP-Seq_HELA_Human	2.10390724
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10058318
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.09378883
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.08100703
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.01417389
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.00751654
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95508178
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.95083361
31	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.94707049
32	GATA1_22025678_ChIP-Seq_K562_Human	1.94228684
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91597084
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.91464773
35	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.88196527
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.87759085
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.86914487
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.83749868
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.78422644
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.77596271
41	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.76342380
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.69776421
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.69648821
44	GATA2_19941826_ChIP-Seq_K562_Human	1.69129243
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.68042186
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66353479
47	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.62022402
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59794702
49	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55684909
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54581979
51	VDR_22108803_ChIP-Seq_LS180_Human	1.48350062
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.46276428
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43856084
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.38782546
55	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.37359186
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.33611908
57	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.28655573
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21829746
59	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.21573899
60	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21463600
61	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.21292395
62	AR_21909140_ChIP-Seq_LNCAP_Human	1.18459245
63	ZNF263_19887448_ChIP-Seq_K562_Human	1.18421455
64	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.18150585
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16010310
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.14464166
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.13498337
68	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.13274941
69	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.10445652
70	SPI1_23127762_ChIP-Seq_K562_Human	1.04702374
71	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03293643
72	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02738885
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01974675
74	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01860853
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00499351
76	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.99889432
77	PHF8_20622853_ChIP-Seq_HELA_Human	0.99658480
78	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99368599
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.98757519
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.98283856
81	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97776050
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.97525853
83	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.94813460
84	SCL_19346495_ChIP-Seq_HPC-7_Human	0.93763820
85	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.91946039
86	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.90633666
87	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.90312212
88	TFEB_21752829_ChIP-Seq_HELA_Human	0.90180858
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88911377
90	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.88852498
91	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88231561
92	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.88197703
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87584844
94	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85616425
95	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.85245306
96	EZH2_22144423_ChIP-Seq_EOC_Human	0.82407155
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.81499598
98	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.80522553
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.79164969
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.79116754

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.82616349
2	MP0008995_early_reproductive_senescence	3.94815955
3	MP0008058_abnormal_DNA_repair	3.71280478
4	MP0004957_abnormal_blastocyst_morpholog	3.56816589
5	MP0010094_abnormal_chromosome_stability	3.31093542
6	MP0003111_abnormal_nucleus_morphology	3.28608717
7	MP0000678_abnormal_parathyroid_gland	3.22124907
8	MP0005451_abnormal_body_composition	3.14755717
9	MP0004145_abnormal_muscle_electrophysio	3.06993461
10	MP0003693_abnormal_embryo_hatching	3.00202811
11	MP0008057_abnormal_DNA_replication	2.91818942
12	MP0008932_abnormal_embryonic_tissue	2.60135347
13	MP0009697_abnormal_copulation	2.58167520
14	MP0003786_premature_aging	2.39291938
15	MP0003656_abnormal_erythrocyte_physiolo	2.31147608
16	MP0005083_abnormal_biliary_tract	2.25698671
17	MP0006292_abnormal_olfactory_placode	2.24464268
18	MP0000372_irregular_coat_pigmentation	2.17476395
19	MP0003077_abnormal_cell_cycle	2.16541539
20	MP0008007_abnormal_cellular_replicative	1.97406250
21	MP0003646_muscle_fatigue	1.96807760
22	MP0006036_abnormal_mitochondrial_physio	1.91380529
23	MP0003718_maternal_effect	1.89447238
24	MP0006035_abnormal_mitochondrial_morpho	1.84856773
25	MP0005408_hypopigmentation	1.84166414
26	MP0001529_abnormal_vocalization	1.81148933
27	MP0002210_abnormal_sex_determination	1.55520147
28	MP0001929_abnormal_gametogenesis	1.53595405
29	MP0001697_abnormal_embryo_size	1.45112635
30	MP0005171_absent_coat_pigmentation	1.43586107
31	MP0005646_abnormal_pituitary_gland	1.39643798
32	MP0002132_abnormal_respiratory_system	1.37220190
33	MP0003186_abnormal_redox_activity	1.33948584
34	MP0001730_embryonic_growth_arrest	1.33396339
35	MP0005397_hematopoietic_system_phenotyp	1.31149106
36	MP0001545_abnormal_hematopoietic_system	1.31149106
37	MP0004134_abnormal_chest_morphology	1.29558383
38	MP0001727_abnormal_embryo_implantation	1.27107967
39	MP0004233_abnormal_muscle_weight	1.25567017
40	MP0002249_abnormal_larynx_morphology	1.22623773
41	MP0005636_abnormal_mineral_homeostasis	1.21829606
42	MP0000350_abnormal_cell_proliferation	1.21248988
43	MP0008775_abnormal_heart_ventricle	1.20127874
44	MP0002080_prenatal_lethality	1.19680527
45	MP0000313_abnormal_cell_death	1.19426736
46	MP0005410_abnormal_fertilization	1.19119550
47	MP0001661_extended_life_span	1.18998267
48	MP0003959_abnormal_lean_body	1.16392082
49	MP0001145_abnormal_male_reproductive	1.15297446
50	MP0000358_abnormal_cell_content/	1.13550362
51	MP0003698_abnormal_male_reproductive	1.12891961
52	MP0008877_abnormal_DNA_methylation	1.12020091
53	MP0000653_abnormal_sex_gland	1.10265397
54	MP0000631_abnormal_neuroendocrine_gland	1.07379207
55	MP0003806_abnormal_nucleotide_metabolis	1.02622773
56	MP0005380_embryogenesis_phenotype	1.00625998
57	MP0001672_abnormal_embryogenesis/_devel	1.00625998
58	MP0003221_abnormal_cardiomyocyte_apopto	0.98165512
59	MP0002160_abnormal_reproductive_system	0.98027253
60	MP0010307_abnormal_tumor_latency	0.93551440
61	MP0002086_abnormal_extraembryonic_tissu	0.91650486
62	MP0003942_abnormal_urinary_system	0.89129490
63	MP0003984_embryonic_growth_retardation	0.88544894
64	MP0002085_abnormal_embryonic_tissue	0.86672066
65	MP0006276_abnormal_autonomic_nervous	0.86116100
66	MP0002088_abnormal_embryonic_growth/wei	0.85566964
67	MP0002095_abnormal_skin_pigmentation	0.85507846
68	MP0000647_abnormal_sebaceous_gland	0.85459423
69	MP0001764_abnormal_homeostasis	0.85318707
70	MP0003937_abnormal_limbs/digits/tail_de	0.83405616
71	MP0002084_abnormal_developmental_patter	0.82334301
72	MP0008872_abnormal_physiological_respon	0.80596409
73	MP0003699_abnormal_female_reproductive	0.79920251
74	MP0005332_abnormal_amino_acid	0.79835058
75	MP0008770_decreased_survivor_rate	0.79818669
76	MP0002161_abnormal_fertility/fecundity	0.78231885
77	MP0005645_abnormal_hypothalamus_physiol	0.77579133
78	MP0003938_abnormal_ear_development	0.77493139
79	MP0003385_abnormal_body_wall	0.76438404
80	MP0001873_stomach_inflammation	0.75762433
81	MP0003123_paternal_imprinting	0.74686534
82	MP0003567_abnormal_fetal_cardiomyocyte	0.74046989
83	MP0002139_abnormal_hepatobiliary_system	0.70948552
84	MP0001502_abnormal_circadian_rhythm	0.70904265
85	MP0002396_abnormal_hematopoietic_system	0.69445751
86	MP0009046_muscle_twitch	0.69158328
87	MP0002837_dystrophic_cardiac_calcinosis	0.68960973
88	MP0002269_muscular_atrophy	0.68889283
89	MP0005389_reproductive_system_phenotype	0.67339656
90	MP0002019_abnormal_tumor_incidence	0.66356685
91	MP0004085_abnormal_heartbeat	0.65772359
92	MP0004197_abnormal_fetal_growth/weight/	0.65554204
93	MP0000609_abnormal_liver_physiology	0.64817775
94	MP0001119_abnormal_female_reproductive	0.61959189
95	MP0004019_abnormal_vitamin_homeostasis	0.61398031
96	MP0001881_abnormal_mammary_gland	0.59738165
97	MP0002938_white_spotting	0.58655601
98	MP0009115_abnormal_fat_cell	0.58487896
99	MP0000681_abnormal_thyroid_gland	0.58166190
100	MP0003950_abnormal_plasma_membrane	0.57918373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	6.74470107
2	Cholecystitis (HP:0001082)	6.74470107
3	Truncus arteriosus (HP:0001660)	6.40489095
4	Hyperthyroidism (HP:0000836)	5.86206079
5	Reticulocytosis (HP:0001923)	5.24370540
6	Abnormality of reticulocytes (HP:0004312)	4.56987812
7	Homocystinuria (HP:0002156)	4.54762444
8	Abnormality of homocysteine metabolism (HP:0010919)	4.54762444
9	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.15951904
10	Polycythemia (HP:0001901)	4.00244226
11	Abnormal hemoglobin (HP:0011902)	3.90170002
12	Bowel incontinence (HP:0002607)	3.89738664
13	Birth length less than 3rd percentile (HP:0003561)	3.89636356
14	Hypertensive crisis (HP:0100735)	3.83702708
15	Abnormal large intestine physiology (HP:0012700)	3.76681211
16	Chromsome breakage (HP:0040012)	3.56950331
17	Abnormality of cochlea (HP:0000375)	3.45142130
18	Ileus (HP:0002595)	3.44449654
19	Seborrheic dermatitis (HP:0001051)	3.37343028
20	Ankyloglossia (HP:0010296)	3.35458065
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.32303312
22	Pallor (HP:0000980)	3.22792671
23	Abnormality of glycolysis (HP:0004366)	3.17990910
24	Reticulocytopenia (HP:0001896)	3.14735384
25	Increased serum pyruvate (HP:0003542)	3.13706734
26	Cortical dysplasia (HP:0002539)	3.10920415
27	Hypoparathyroidism (HP:0000829)	3.07744025
28	Cholelithiasis (HP:0001081)	3.05884588
29	Atelectasis (HP:0100750)	2.97727556
30	Poikilocytosis (HP:0004447)	2.95325306
31	Abnormality of the tricuspid valve (HP:0001702)	2.92262152
32	Upper limb muscle weakness (HP:0003484)	2.84561070
33	Abnormal gallbladder morphology (HP:0012437)	2.79284494
34	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.77864226
35	Tinnitus (HP:0000360)	2.74821152
36	Morphological abnormality of the inner ear (HP:0011390)	2.72024524
37	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.69700303
38	Acute myeloid leukemia (HP:0004808)	2.65677648
39	Hyperbilirubinemia (HP:0002904)	2.39244780
40	Acute encephalopathy (HP:0006846)	2.38023354
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.36023571
42	Abnormality of DNA repair (HP:0003254)	2.33400895
43	Abnormal number of erythroid precursors (HP:0012131)	2.28825710
44	Duplicated collecting system (HP:0000081)	2.28457146
45	Abnormality of the renal collecting system (HP:0004742)	2.26689409
46	Acute necrotizing encephalopathy (HP:0006965)	2.26450542
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.26163370
48	Abnormality of oral frenula (HP:0000190)	2.25295430
49	Abnormality of the gallbladder (HP:0005264)	2.25272430
50	Abnormality of methionine metabolism (HP:0010901)	2.21504784
51	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.18064643
52	Angiofibromas (HP:0010615)	2.17392291
53	Adenoma sebaceum (HP:0009720)	2.17392291
54	Nonimmune hydrops fetalis (HP:0001790)	2.14536678
55	Flat cornea (HP:0007720)	2.11170512
56	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.09460732
57	Abnormality of chromosome stability (HP:0003220)	2.07182878
58	Abnormality of the preputium (HP:0100587)	2.05575966
59	Myelodysplasia (HP:0002863)	2.05123545
60	Abnormally folded helix (HP:0008544)	2.01229573
61	Acanthocytosis (HP:0001927)	2.00825719
62	Peripheral hypomyelination (HP:0007182)	1.99104771
63	Methylmalonic acidemia (HP:0002912)	1.98646031
64	Macrocytic anemia (HP:0001972)	1.97808234
65	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.97674069
66	Orthostatic hypotension (HP:0001278)	1.97667587
67	Small intestinal stenosis (HP:0012848)	1.97178411
68	Duodenal stenosis (HP:0100867)	1.97178411
69	Palpitations (HP:0001962)	1.91755019
70	Abnormal lung lobation (HP:0002101)	1.91427338
71	Patellar dislocation (HP:0002999)	1.90076252
72	Cheekbone underdevelopment (HP:0010669)	1.89263208
73	Progressive macrocephaly (HP:0004481)	1.88345559
74	Sandal gap (HP:0001852)	1.85729012
75	Insomnia (HP:0100785)	1.83850359
76	Obsessive-compulsive behavior (HP:0000722)	1.83805465
77	Increased nuchal translucency (HP:0010880)	1.82821064
78	Premature ovarian failure (HP:0008209)	1.82638873
79	Conjunctival hamartoma (HP:0100780)	1.80755645
80	Attention deficit hyperactivity disorder (HP:0007018)	1.80751973
81	Cerebral hypomyelination (HP:0006808)	1.77009462
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75121961
83	Increased CSF lactate (HP:0002490)	1.74738906
84	Pheochromocytoma (HP:0002666)	1.74633717
85	Ventricular fibrillation (HP:0001663)	1.74310519
86	Abnormality of the labia minora (HP:0012880)	1.72423093
87	Increased hepatocellular lipid droplets (HP:0006565)	1.72283988
88	Short middle phalanx of the 5th finger (HP:0004220)	1.70820490
89	Increased serum lactate (HP:0002151)	1.68009992
90	Abnormality of the carotid arteries (HP:0005344)	1.66865413
91	Overlapping toe (HP:0001845)	1.65851360
92	Venous insufficiency (HP:0005293)	1.63353231
93	Hypoplastic pelvis (HP:0008839)	1.62192225
94	Cafe-au-lait spot (HP:0000957)	1.61439332
95	Septate vagina (HP:0001153)	1.61048949
96	Redundant skin (HP:0001582)	1.60572578
97	Breech presentation (HP:0001623)	1.59912643
98	Overfolded helix (HP:0000396)	1.59781704
99	Horseshoe kidney (HP:0000085)	1.59256394
100	Decreased subcutaneous fat (HP:0001002)	1.58584580

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.39109988
2	RIPK4	4.21583701
3	TTK	3.52520784
4	CLK1	3.48756818
5	KSR2	3.40413493
6	NTRK3	2.95318700
7	TNIK	2.68548273
8	CDC7	2.60224266
9	PLK4	2.50102178
10	SRPK1	2.46590820
11	BRSK2	2.45987584
12	PBK	2.45630623
13	RAF1	2.43277355
14	BMPR2	2.40975407
15	CCNB1	2.40616038
16	MAP3K2	2.37356928
17	WEE1	2.34847012
18	EEF2K	2.09271897
19	NME1	2.02135210
20	KSR1	1.96285328
21	MAP3K4	1.87677763
22	TSSK6	1.84774907
23	NEK1	1.78310212
24	NEK2	1.53619054
25	BUB1	1.42765084
26	CHEK2	1.35022595
27	PDK2	1.34969769
28	MAP3K8	1.34110412
29	BRSK1	1.28805136
30	EIF2AK3	1.21592437
31	ATR	1.15991297
32	MST4	1.09345846
33	PLK3	1.09129928
34	BMX	1.00655715
35	ALK	0.97968757
36	STK4	0.97547642
37	ZAK	0.93292188
38	ICK	0.92754627
39	WNK4	0.91608141
40	CHEK1	0.91566437
41	PLK1	0.87610612
42	PIK3CG	0.84155977
43	RPS6KB2	0.81976788
44	STK3	0.81299513
45	NME2	0.78890702
46	CDK1	0.78549808
47	ATM	0.77166989
48	MAP2K1	0.76292056
49	DYRK3	0.76224840
50	IRAK3	0.73205995
51	JAK2	0.72956037
52	TRPM7	0.70377459
53	MAPKAPK5	0.70363556
54	PAK1	0.69333683
55	BRAF	0.69219818
56	CDK2	0.69077869
57	EPHA3	0.61477605
58	CSNK2A2	0.58924335
59	CSNK1E	0.56912922
60	AURKB	0.55749948
61	RET	0.53295846
62	MKNK1	0.52920035
63	SGK1	0.50570191
64	CDK12	0.50346559
65	MAPK13	0.49716068
66	MAP3K1	0.46952029
67	MAP2K7	0.46666276
68	TEC	0.45947409
69	TAOK3	0.45827960
70	CSNK2A1	0.44950171
71	MARK3	0.44400040
72	SCYL2	0.43857817
73	YES1	0.42579877
74	PLK2	0.42391226
75	AURKA	0.42079650
76	PINK1	0.39681454
77	NUAK1	0.39414517
78	VRK1	0.38998206
79	RPS6KA5	0.38969934
80	MAP3K6	0.36813704
81	STK16	0.35998070
82	MTOR	0.35738725
83	PRKDC	0.35315091
84	GSK3B	0.34673842
85	PRKAA1	0.34253860
86	WNK1	0.33721405
87	MAPK14	0.32570101
88	BRD4	0.32246966
89	AKT3	0.31116652
90	SIK2	0.30004673
91	PTK6	0.29806381
92	PIM1	0.29438054
93	CDK7	0.28439250
94	BTK	0.28345246
95	MATK	0.26868424
96	EIF2AK2	0.26594605
97	PRKACG	0.26143193
98	AKT1	0.25494253
99	PAK2	0.23150054
100	CDK11A	0.22358787

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.45443151
2	DNA replication_Homo sapiens_hsa03030	3.64917402
3	Mismatch repair_Homo sapiens_hsa03430	3.43387718
4	Homologous recombination_Homo sapiens_hsa03440	3.31589967
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.28171062
6	One carbon pool by folate_Homo sapiens_hsa00670	3.19656531
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.81142359
8	Ribosome_Homo sapiens_hsa03010	2.53130718
9	RNA transport_Homo sapiens_hsa03013	2.49895325
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.23147996
11	Spliceosome_Homo sapiens_hsa03040	2.18590341
12	RNA polymerase_Homo sapiens_hsa03020	2.16275845
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15953814
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.13808506
15	Basal transcription factors_Homo sapiens_hsa03022	2.03809914
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.94556402
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92435810
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.90721952
19	Parkinsons disease_Homo sapiens_hsa05012	1.84024812
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.82295792
21	Pyruvate metabolism_Homo sapiens_hsa00620	1.78326599
22	Cell cycle_Homo sapiens_hsa04110	1.77312760
23	Base excision repair_Homo sapiens_hsa03410	1.54241575
24	RNA degradation_Homo sapiens_hsa03018	1.43981942
25	Proteasome_Homo sapiens_hsa03050	1.43291406
26	Olfactory transduction_Homo sapiens_hsa04740	1.42243123
27	Huntingtons disease_Homo sapiens_hsa05016	1.40968370
28	Carbon metabolism_Homo sapiens_hsa01200	1.36132753
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.35523277
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29291059
31	Protein export_Homo sapiens_hsa03060	1.27871483
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.26387493
33	Type II diabetes mellitus_Homo sapiens_hsa04930	1.23166225
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20772470
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19802695
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.13485180
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.11806513
38	Purine metabolism_Homo sapiens_hsa00230	1.08573020
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.07944183
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07175802
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06878547
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.05292941
43	Propanoate metabolism_Homo sapiens_hsa00640	1.04571199
44	Alzheimers disease_Homo sapiens_hsa05010	1.01155079
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.96034156
46	Butanoate metabolism_Homo sapiens_hsa00650	0.94152688
47	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.93944804
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83492308
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82814319
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.80966420
51	Oocyte meiosis_Homo sapiens_hsa04114	0.77121350
52	Acute myeloid leukemia_Homo sapiens_hsa05221	0.71544816
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70766405
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70464136
55	Nicotine addiction_Homo sapiens_hsa05033	0.70175695
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.67793621
57	Fatty acid elongation_Homo sapiens_hsa00062	0.66770932
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.65992296
59	Arginine biosynthesis_Homo sapiens_hsa00220	0.63924013
60	Thyroid cancer_Homo sapiens_hsa05216	0.62967245
61	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.59379128
62	Metabolic pathways_Homo sapiens_hsa01100	0.56588056
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55509694
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51048381
65	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.47116863
66	ErbB signaling pathway_Homo sapiens_hsa04012	0.47092573
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46876220
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45807473
69	Glutathione metabolism_Homo sapiens_hsa00480	0.43290073
70	VEGF signaling pathway_Homo sapiens_hsa04370	0.41216844
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.41073197
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.40271813
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40047470
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39410160
75	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.38960095
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.38235797
77	Sulfur relay system_Homo sapiens_hsa04122	0.36592430
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.32808787
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32642489
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32240092
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31471680
82	Renal cell carcinoma_Homo sapiens_hsa05211	0.30292181
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29061045
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28580624
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27762550
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.27195580
87	Folate biosynthesis_Homo sapiens_hsa00790	0.27136544
88	Phototransduction_Homo sapiens_hsa04744	0.23041016
89	Insulin signaling pathway_Homo sapiens_hsa04910	0.22506846
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22328931
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.22237738
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.21256594
93	Galactose metabolism_Homo sapiens_hsa00052	0.21140438
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.20885607
95	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.20336414
96	MicroRNAs in cancer_Homo sapiens_hsa05206	0.17163013
97	Sulfur metabolism_Homo sapiens_hsa00920	0.16871921
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.14157839
99	Lysine degradation_Homo sapiens_hsa00310	0.13732856
100	Non-small cell lung cancer_Homo sapiens_hsa05223	0.13327585

CT55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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