CT62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phosphoprotein phosphatase activity (GO:0043666)9.65845800
2positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.40426724
3positive regulation of catecholamine secretion (GO:0033605)9.10273629
4male meiosis (GO:0007140)8.26170934
5acrosome reaction (GO:0007340)7.80016214
6spermatid development (GO:0007286)7.45930796
7sperm motility (GO:0030317)7.13463180
8motile cilium assembly (GO:0044458)7.05460764
9regulation of oxidative stress-induced neuron death (GO:1903203)6.82177884
10binding of sperm to zona pellucida (GO:0007339)6.76602380
11multicellular organism reproduction (GO:0032504)6.61183640
12nucleosome disassembly (GO:0006337)6.49370933
13protein-DNA complex disassembly (GO:0032986)6.49370933
14axonemal dynein complex assembly (GO:0070286)6.41662165
15relaxation of smooth muscle (GO:0044557)6.33257105
16Leydig cell differentiation (GO:0033327)5.67430778
17regulation of oxidative phosphorylation (GO:0002082)5.63460334
18cilium or flagellum-dependent cell motility (GO:0001539)5.46965752
19activation of protein kinase B activity (GO:0032148)5.34057745
20sperm-egg recognition (GO:0035036)5.31229955
21polyamine biosynthetic process (GO:0006596)5.20115436
22potassium ion export (GO:0071435)5.20001419
23negative regulation of hydrogen peroxide-induced cell death (GO:1903206)5.12622927
24organic cation transport (GO:0015695)5.10568683
25cGMP-mediated signaling (GO:0019934)5.05250363
26TOR signaling (GO:0031929)4.94196393
27epithelial cilium movement (GO:0003351)4.78321590
28regulation of autophagic vacuole assembly (GO:2000785)4.73269813
29synapsis (GO:0007129)4.64428848
30reproduction (GO:0000003)4.64428820
31male sex determination (GO:0030238)4.63658314
32negative regulation of response to reactive oxygen species (GO:1901032)4.62563657
33cell-cell recognition (GO:0009988)4.60970727
34negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.60639776
35regulation of hydrogen peroxide-induced cell death (GO:1903205)4.54535710
36germ cell development (GO:0007281)4.45967829
37single fertilization (GO:0007338)4.42788001
38response to acidic pH (GO:0010447)4.41873137
39ventricular system development (GO:0021591)4.39447732
40glycogen metabolic process (GO:0005977)4.29184948
41glutamine family amino acid catabolic process (GO:0009065)4.23990115
42androgen biosynthetic process (GO:0006702)4.23677934
43glucan metabolic process (GO:0044042)4.23558933
44cellular glucan metabolic process (GO:0006073)4.23558933
45protein polymerization (GO:0051258)4.22110673
46cilium movement (GO:0003341)4.20871771
47coenzyme catabolic process (GO:0009109)4.16181124
48regulation of dopamine secretion (GO:0014059)4.06589237
49fusion of sperm to egg plasma membrane (GO:0007342)4.05587681
50mitochondrion degradation (GO:0000422)3.99538556
51positive regulation of glycolytic process (GO:0045821)3.94658603
52regulation of vacuole organization (GO:0044088)3.82190778
53oogenesis (GO:0048477)3.75324540
54dicarboxylic acid biosynthetic process (GO:0043650)3.72479573
55regulation of cellular respiration (GO:0043457)3.68913164
56regulation of phosphatase activity (GO:0010921)3.60917711
57acrosome assembly (GO:0001675)3.60721702
58negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.58581458
59chromosome organization involved in meiosis (GO:0070192)3.57940155
60negative regulation of smooth muscle contraction (GO:0045986)3.52457618
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.51841080
62oligosaccharide biosynthetic process (GO:0009312)3.50308599
63cellular response to toxic substance (GO:0097237)3.49808596
64hemidesmosome assembly (GO:0031581)3.49061282
65negative regulation of inclusion body assembly (GO:0090084)3.46823098
66ectoderm development (GO:0007398)3.40991289
67calcium ion-dependent exocytosis (GO:0017156)3.39757317
68cellular zinc ion homeostasis (GO:0006882)3.39741856
69negative regulation of JNK cascade (GO:0046329)3.38172313
70tongue development (GO:0043586)3.36629546
71histone exchange (GO:0043486)3.36048371
72cellular biogenic amine biosynthetic process (GO:0042401)3.35654292
73amine biosynthetic process (GO:0009309)3.33219807
74membrane repolarization during action potential (GO:0086011)3.32661485
75aspartate family amino acid catabolic process (GO:0009068)3.31369648
76negative regulation of striated muscle cell apoptotic process (GO:0010664)3.27344593
77phosphatidylethanolamine biosynthetic process (GO:0006646)3.24265404
78regulation of synaptic transmission, dopaminergic (GO:0032225)3.22881991
79cellular response to pH (GO:0071467)3.15856258
80plasma membrane fusion (GO:0045026)3.14845043
81fertilization (GO:0009566)3.13384160
82positive regulation of amine transport (GO:0051954)3.11428742
83meiotic nuclear division (GO:0007126)3.00469358
84polyamine metabolic process (GO:0006595)3.00015074
85cellular polysaccharide metabolic process (GO:0044264)2.99114923
86histone H3-K9 demethylation (GO:0033169)2.97611120
87negative regulation of stress-activated MAPK cascade (GO:0032873)2.96618291
88negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.96618291
89mesonephros development (GO:0001823)2.96348424
90synaptonemal complex assembly (GO:0007130)2.96033646
91regulation of protein kinase C signaling (GO:0090036)2.95598939
92receptor catabolic process (GO:0032801)2.94534014
93diacylglycerol metabolic process (GO:0046339)2.93900391
94protein localization to cell surface (GO:0034394)2.90614565
95phosphatidylethanolamine metabolic process (GO:0046337)2.90455186
96regulation of dephosphorylation (GO:0035303)2.89531496
97regulation of ARF GTPase activity (GO:0032312)2.88753765
98histone H3-K36 demethylation (GO:0070544)2.84626020
99polysaccharide metabolic process (GO:0005976)2.81457129
100sex determination (GO:0007530)2.81362502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.40658213
2ESR1_20079471_ChIP-ChIP_T-47D_Human6.45260824
3IGF1R_20145208_ChIP-Seq_DFB_Human3.93896726
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40914966
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.95877861
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.83671303
7* AHR_22903824_ChIP-Seq_MCF-7_Human2.52506977
8* ARNT_22903824_ChIP-Seq_MCF-7_Human2.41883523
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.20119160
10AR_21909140_ChIP-Seq_LNCAP_Human2.17340363
11ZNF263_19887448_ChIP-Seq_K562_Human2.11385449
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03609524
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.7950817
14* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94758940
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.91302309
16AR_21572438_ChIP-Seq_LNCaP_Human1.89780858
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81499189
18ER_23166858_ChIP-Seq_MCF-7_Human1.67768560
19RUNX1_27514584_Chip-Seq_MCF-7_Human1.66785092
20CTCF_27219007_Chip-Seq_Bcells_Human1.63335995
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52111877
22FUS_26573619_Chip-Seq_HEK293_Human1.47923452
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.47586850
24TP53_18474530_ChIP-ChIP_U2OS_Human1.46277248
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45560798
26* SMC4_20622854_ChIP-Seq_HELA_Human1.44055422
27EZH2_22144423_ChIP-Seq_EOC_Human1.39754946
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38155821
29ELF5_23300383_ChIP-Seq_T47D_Human1.37628480
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37437465
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37178292
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37178292
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28691459
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27884522
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26056191
36* NANOG_20526341_ChIP-Seq_ESCs_Human1.25783371
37* RAC3_21632823_ChIP-Seq_H3396_Human1.24712677
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21829704
39GBX2_23144817_ChIP-Seq_PC3_Human1.21711476
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20751169
41OCT4_20526341_ChIP-Seq_ESCs_Human1.18454418
42* ERA_21632823_ChIP-Seq_H3396_Human1.17589979
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.16657197
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16552702
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15862506
46CBP_20019798_ChIP-Seq_JUKART_Human1.15862506
47MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15627691
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14151882
49CJUN_26792858_Chip-Seq_BT549_Human1.09545442
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.07389323
51* OCT1_27270436_Chip-Seq_PROSTATE_Human1.06756864
52BCAT_22108803_ChIP-Seq_LS180_Human1.04990914
53* LXR_22292898_ChIP-Seq_THP-1_Human1.04539367
54RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03173733
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02965916
56RXR_22108803_ChIP-Seq_LS180_Human1.02711683
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01771755
58CTCF_20526341_ChIP-Seq_ESCs_Human1.01512635
59TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00163016
60KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99326144
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96439200
62P68_20966046_ChIP-Seq_HELA_Human0.95095647
63FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94750222
64* TP63_22573176_ChIP-Seq_HFKS_Human0.94743467
65ERG_20517297_ChIP-Seq_VCAP_Human0.94454391
66SMAD3_21741376_ChIP-Seq_EPCs_Human0.93509210
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92390863
68RACK7_27058665_Chip-Seq_MCF-7_Human0.91143333
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91086974
70MYC_19829295_ChIP-Seq_ESCs_Human0.90704366
71SMAD4_21799915_ChIP-Seq_A2780_Human0.88146474
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87810808
73* TP63_23658742_ChIP-Seq_EP156T_Human0.87178956
74RUNX2_22187159_ChIP-Seq_PCA_Human0.86487034
75* TBL1_22424771_ChIP-Seq_293T_Human0.82093682
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80401121
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79236949
78P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78785005
79* GATA3_24758297_ChIP-Seq_MCF-7_Human0.78564912
80VDR_22108803_ChIP-Seq_LS180_Human0.78514118
81SMAD4_21741376_ChIP-Seq_EPCs_Human0.78062452
82E2F1_17053090_ChIP-ChIP_MCF-7_Human0.77803293
83SPI1_20517297_ChIP-Seq_HL60_Human0.77437156
84GF1B_26923725_Chip-Seq_HPCs_Mouse0.77148752
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77116587
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77021104
87P53_22127205_ChIP-Seq_FIBROBLAST_Human0.76596206
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.76441286
89* HOXB7_26014856_ChIP-Seq_BT474_Human0.75533130
90GATA1_22025678_ChIP-Seq_K562_Human0.75281454
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74782407
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74566101
93KDM2B_26808549_Chip-Seq_DND41_Human0.73502138
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72580341
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.71833218
96PHF8_20622854_ChIP-Seq_HELA_Human0.71731432
97KDM2B_26808549_Chip-Seq_K562_Human0.71582209
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.70921477
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.70772351
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70188500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.62776548
2MP0003315_abnormal_perineum_morphology6.65545125
3MP0008004_abnormal_stomach_pH5.04862636
4MP0002160_abnormal_reproductive_system3.91410164
5MP0005360_urolithiasis3.42270599
6MP0000537_abnormal_urethra_morphology3.39209041
7MP0004272_abnormal_basement_membrane2.50703690
8MP0003045_fibrosis2.45863379
9MP0010368_abnormal_lymphatic_system2.42569022
10MP0010234_abnormal_vibrissa_follicle2.41999496
11MP0003698_abnormal_male_reproductive2.41456401
12MP0005058_abnormal_lysosome_morphology2.25060083
13MP0001929_abnormal_gametogenesis2.15762717
14MP0000538_abnormal_urinary_bladder2.08835316
15MP0001664_abnormal_digestion2.06880386
16MP0004264_abnormal_extraembryonic_tissu2.04571945
17MP0001849_ear_inflammation2.02816030
18MP0005389_reproductive_system_phenotype1.97045963
19MP0002796_impaired_skin_barrier1.96965675
20MP0002132_abnormal_respiratory_system1.91645437
21MP0005187_abnormal_penis_morphology1.89870394
22MP0000678_abnormal_parathyroid_gland1.87341615
23MP0005248_abnormal_Harderian_gland1.85610654
24MP0005409_darkened_coat_color1.85458951
25MP0010386_abnormal_urinary_bladder1.83328256
26MP0000579_abnormal_nail_morphology1.76695146
27MP0005647_abnormal_sex_gland1.67655550
28MP0005394_taste/olfaction_phenotype1.67394134
29MP0005499_abnormal_olfactory_system1.67394134
30MP0001984_abnormal_olfaction1.64464420
31MP0000762_abnormal_tongue_morphology1.64377301
32MP0003941_abnormal_skin_development1.60954829
33MP0003136_yellow_coat_color1.60133836
34MP0004381_abnormal_hair_follicle1.49564861
35MP0004782_abnormal_surfactant_physiolog1.36740017
36MP0003936_abnormal_reproductive_system1.34851584
37MP0000467_abnormal_esophagus_morphology1.32128884
38MP0001188_hyperpigmentation1.29337182
39MP0002161_abnormal_fertility/fecundity1.28858803
40MP0001919_abnormal_reproductive_system1.21721030
41MP0002249_abnormal_larynx_morphology1.18640047
42MP0003705_abnormal_hypodermis_morpholog1.18388527
43MP0005083_abnormal_biliary_tract1.15452751
44MP0002210_abnormal_sex_determination1.14399440
45MP0001145_abnormal_male_reproductive1.11116554
46MP0000470_abnormal_stomach_morphology1.10440624
47MP0000627_abnormal_mammary_gland1.09430961
48MP0004084_abnormal_cardiac_muscle1.07035625
49MP0009697_abnormal_copulation1.02851105
50MP0005275_abnormal_skin_tensile1.01919770
51MP0008995_early_reproductive_senescence1.00641636
52MP0006072_abnormal_retinal_apoptosis1.00489713
53MP0000653_abnormal_sex_gland0.94842069
54MP0005501_abnormal_skin_physiology0.94253136
55MP0002127_abnormal_cardiovascular_syste0.94139068
56MP0001905_abnormal_dopamine_level0.93487676
57MP0000462_abnormal_digestive_system0.92675434
58MP0005503_abnormal_tendon_morphology0.89768618
59MP0002168_other_aberrant_phenotype0.89261991
60MP0002282_abnormal_trachea_morphology0.86670290
61MP0005395_other_phenotype0.86238168
62MP0010678_abnormal_skin_adnexa0.83032872
63MP0003453_abnormal_keratinocyte_physiol0.80350190
64MP0000427_abnormal_hair_cycle0.79650984
65MP0003718_maternal_effect0.79093904
66MP0004085_abnormal_heartbeat0.78741927
67MP0009780_abnormal_chondrocyte_physiolo0.77601013
68MP0002108_abnormal_muscle_morphology0.75022234
69MP0009250_abnormal_appendicular_skeleto0.71663398
70MP0000465_gastrointestinal_hemorrhage0.71538782
71MP0000534_abnormal_ureter_morphology0.71514983
72MP0001216_abnormal_epidermal_layer0.71395251
73MP0000049_abnormal_middle_ear0.70764076
74MP0005595_abnormal_vascular_smooth0.70024438
75MP0008789_abnormal_olfactory_epithelium0.69399765
76MP0002060_abnormal_skin_morphology0.69107713
77MP0003755_abnormal_palate_morphology0.66501240
78MP0001270_distended_abdomen0.66290830
79MP0002254_reproductive_system_inflammat0.65868971
80MP0002233_abnormal_nose_morphology0.65127972
81MP0005646_abnormal_pituitary_gland0.63798610
82MP0003632_abnormal_nervous_system0.63474208
83MP0004036_abnormal_muscle_relaxation0.63025828
84MP0003385_abnormal_body_wall0.61795005
85MP0002098_abnormal_vibrissa_morphology0.61271336
86MP0003566_abnormal_cell_adhesion0.59924379
87MP0003693_abnormal_embryo_hatching0.59090529
88MP0001340_abnormal_eyelid_morphology0.57430898
89MP0000566_synostosis0.57393122
90MP0005623_abnormal_meninges_morphology0.56483579
91MP0004233_abnormal_muscle_weight0.55802413
92MP0000733_abnormal_muscle_development0.55182023
93MP0010771_integument_phenotype0.54733436
94MP0003935_abnormal_craniofacial_develop0.54649203
95MP0002115_abnormal_skeleton_extremities0.54564627
96MP0000343_altered_response_to0.51795760
97MP0009840_abnormal_foam_cell0.51269340
98MP0005620_abnormal_muscle_contractility0.51207404
99MP0001661_extended_life_span0.48784957
100MP0000383_abnormal_hair_follicle0.46902814

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the uterus (HP:0000013)6.79775438
2Resting tremor (HP:0002322)6.73589222
3Abnormal sex determination (HP:0012244)6.54480711
4Sex reversal (HP:0012245)6.54480711
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.82604270
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.15262579
7Absent/shortened dynein arms (HP:0200106)5.15262579
8Abnormal respiratory motile cilium physiology (HP:0012261)5.05514903
9Aplasia/hypoplasia of the uterus (HP:0008684)5.03939480
10Abnormality of the columella (HP:0009929)4.99300778
11Abnormal ciliary motility (HP:0012262)4.84287121
12Reduced antithrombin III activity (HP:0001976)4.83455571
13Germ cell neoplasia (HP:0100728)4.52580046
14Gonadal dysgenesis (HP:0000133)4.39870441
15Infertility (HP:0000789)4.38069249
16Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.02800466
17Male pseudohermaphroditism (HP:0000037)4.00223037
18Facial hemangioma (HP:0000329)4.00158477
19Abnormal respiratory motile cilium morphology (HP:0005938)3.99669101
20Abnormal respiratory epithelium morphology (HP:0012253)3.99669101
21Colitis (HP:0002583)3.86694739
22Ventricular fibrillation (HP:0001663)3.80441538
23Postural instability (HP:0002172)3.61225347
24Cerebellar dysplasia (HP:0007033)3.48681531
25Urinary urgency (HP:0000012)3.39567818
26Thoracic kyphosis (HP:0002942)3.34860817
27Abnormality of the frontal sinuses (HP:0002687)3.32072220
28Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.27290098
29Self-mutilation (HP:0000742)3.18051256
30Thoracolumbar scoliosis (HP:0002944)3.13627760
31Rhinitis (HP:0012384)3.01175004
32Abnormality of the intrinsic pathway (HP:0010989)2.99397478
33Capillary hemangiomas (HP:0005306)2.97385962
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90127414
35Buphthalmos (HP:0000557)2.89986149
36Type II lissencephaly (HP:0007260)2.83047309
37Abnormality of nail color (HP:0100643)2.80811015
38Nasal polyposis (HP:0100582)2.72623648
39Milia (HP:0001056)2.71966389
40Atonic seizures (HP:0010819)2.70690098
41Abnormality of the thoracic spine (HP:0100711)2.67547622
42Chronic bronchitis (HP:0004469)2.59371734
43Spinal rigidity (HP:0003306)2.59326888
44Sensory axonal neuropathy (HP:0003390)2.51507871
45Protruding tongue (HP:0010808)2.46996881
46Abnormality of the nasal mucosa (HP:0000433)2.41925213
47Aplasia cutis congenita (HP:0001057)2.39215183
48Inflammation of the large intestine (HP:0002037)2.38933025
49Retinal atrophy (HP:0001105)2.35603285
50Aortic aneurysm (HP:0004942)2.34589792
51Abnormality of the lumbar spine (HP:0100712)2.34279511
52Retinal dysplasia (HP:0007973)2.32467662
53Short nail (HP:0001799)2.30090912
54Gastrointestinal inflammation (HP:0004386)2.25047873
55Occipital encephalocele (HP:0002085)2.22547330
56Onycholysis (HP:0001806)2.12919137
57Coxa valga (HP:0002673)2.12552340
58Atrophic scars (HP:0001075)2.11093096
59Syncope (HP:0001279)2.10352894
60Congenital glaucoma (HP:0001087)2.10309631
61Hyporeflexia of lower limbs (HP:0002600)2.02397999
62Bronchiectasis (HP:0002110)2.01370655
63High anterior hairline (HP:0009890)2.00134882
64Hypoplasia of dental enamel (HP:0006297)1.98782809
65Renal dysplasia (HP:0000110)1.98124846
66Anterior segment dysgenesis (HP:0007700)1.97644643
67Taurodontia (HP:0000679)1.94256965
68Abnormality of permanent molar morphology (HP:0011071)1.94256965
69Abnormality of the dental root (HP:0006486)1.94256965
70Right ventricular cardiomyopathy (HP:0011663)1.91375334
71Difficulty climbing stairs (HP:0003551)1.90632020
72Absent thumb (HP:0009777)1.89228949
73Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88842059
74Flattened epiphyses (HP:0003071)1.85775941
75Inability to walk (HP:0002540)1.83738539
76Plantar hyperkeratosis (HP:0007556)1.82954198
77Abnormality of molar morphology (HP:0011070)1.82646926
78Abnormality of molar (HP:0011077)1.82646926
79High pitched voice (HP:0001620)1.82478426
80Fragile nails (HP:0001808)1.80955829
81Pili torti (HP:0003777)1.75669198
82Abnormality of dentin (HP:0010299)1.73748535
83Abnormality of male internal genitalia (HP:0000022)1.70589022
84Abnormality of the dental pulp (HP:0006479)1.70343439
85Congenital sensorineural hearing impairment (HP:0008527)1.68839114
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63505895
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63505895
88Facial diplegia (HP:0001349)1.62436696
89Cystic liver disease (HP:0006706)1.57425532
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.57290270
91Abnormal protein N-linked glycosylation (HP:0012347)1.57290270
92Abnormal protein glycosylation (HP:0012346)1.57290270
93Abnormal glycosylation (HP:0012345)1.57290270
94Squamous cell carcinoma (HP:0002860)1.56858693
95Asymmetry of the thorax (HP:0001555)1.56657974
96Absent speech (HP:0001344)1.55803041
97Depression (HP:0000716)1.55588913
98Unsteady gait (HP:0002317)1.54339098
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.53801157
100Median cleft lip (HP:0000161)1.53508443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.68384705
2MYLK3.85934316
3TLK13.72557035
4ZAK3.47526936
5LATS12.65234066
6RPS6KA52.63491685
7NEK22.06844009
8MST1R2.04931136
9STK382.01386428
10PINK110.9137054
11TRIB31.80595618
12LATS21.64362518
13EPHA21.52523014
14STK38L1.46898483
15MAP2K71.44896876
16PKN21.32132134
17MAP3K91.28922452
18MAPK151.15419051
19ARAF1.13857704
20SIK11.09872441
21CDC42BPA1.01165566
22CDK30.97829629
23MUSK0.95508890
24SGK2230.93457501
25SGK4940.93457501
26NME20.91738074
27DYRK30.89272726
28FRK0.87724404
29MET0.83976461
30PAK20.82900518
31CSNK1A1L0.77981959
32PRKG20.74416064
33ICK0.73808547
34MELK0.72113581
35RIPK10.69907020
36EEF2K0.69499515
37MAP3K130.67996003
38RET0.67001293
39MAPKAPK30.65734579
40ILK0.64532996
41MTOR0.63004225
42MAP3K10.58660796
43CDK140.58246445
44PDGFRA0.56156467
45DAPK30.55296340
46RPS6KB10.53829931
47CDK120.53410544
48CSNK1G30.52261109
49PDPK10.51601578
50PAK10.51025099
51GRK60.49323216
52ROCK10.49034399
53VRK10.48255192
54MAP3K50.45641309
55TESK10.44569114
56PTK2B0.44415388
57RPS6KA20.43666375
58PTK20.40709547
59RPS6KB20.39981298
60PRKCQ0.38940255
61TGFBR10.38288655
62RPS6KA40.37094645
63EIF2AK30.36811010
64CDK80.36036943
65PBK0.35805305
66EPHB10.33210727
67CSNK1G10.32541322
68FGFR20.31685116
69NEK60.30689346
70CDK70.28826394
71PAK40.28274855
72AKT20.28081348
73GRK10.27733800
74PKN10.27262387
75PIK3CA0.26772759
76MOS0.26724323
77PRKD30.24550474
78EGFR0.23939706
79RPS6KA10.23808914
80CSNK1G20.23547508
81BMPR1B0.23390423
82AURKB0.22643512
83OBSCN0.22402666
84MAP3K60.22303574
85AKT30.22131906
86PDK10.22077986
87AURKA0.21733489
88BRAF0.21343636
89CDK50.20345378
90FGR0.19763880
91CAMK2G0.18759002
92STK30.18276314
93CAMK10.17995816
94CSNK1A10.17855989
95SGK20.17699294
96CAMK2B0.17454736
97ATM0.17261244
98SGK30.16729225
99PRKG10.16326138
100PTK60.15368424

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051307.66400969
2Gap junction_Homo sapiens_hsa045405.30212735
3Hedgehog signaling pathway_Homo sapiens_hsa043403.20703924
4Nitrogen metabolism_Homo sapiens_hsa009103.13140283
5Apoptosis_Homo sapiens_hsa042102.94088930
6Systemic lupus erythematosus_Homo sapiens_hsa053222.90409788
7Alcoholism_Homo sapiens_hsa050342.46023648
8Phagosome_Homo sapiens_hsa041452.33394856
9Arginine biosynthesis_Homo sapiens_hsa002202.25213984
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.03179363
11Olfactory transduction_Homo sapiens_hsa047401.80989879
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53494492
13Dorso-ventral axis formation_Homo sapiens_hsa043201.31733071
14Glutathione metabolism_Homo sapiens_hsa004801.30901094
15Phenylalanine metabolism_Homo sapiens_hsa003601.21235813
16Propanoate metabolism_Homo sapiens_hsa006401.20522543
17Pyruvate metabolism_Homo sapiens_hsa006201.19847002
18ECM-receptor interaction_Homo sapiens_hsa045121.17848452
19Pentose phosphate pathway_Homo sapiens_hsa000301.15003823
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12122834
21Butanoate metabolism_Homo sapiens_hsa006501.10496998
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.08904846
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08310385
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.06781694
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06173756
26Glucagon signaling pathway_Homo sapiens_hsa049221.06071517
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02400671
28Endometrial cancer_Homo sapiens_hsa052130.94533269
29Taste transduction_Homo sapiens_hsa047420.94090367
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92605225
31Focal adhesion_Homo sapiens_hsa045100.90398168
32Renin secretion_Homo sapiens_hsa049240.89661813
33Estrogen signaling pathway_Homo sapiens_hsa049150.89062199
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88330927
35Oocyte meiosis_Homo sapiens_hsa041140.86205318
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79631761
37Chemical carcinogenesis_Homo sapiens_hsa052040.79607061
38Dilated cardiomyopathy_Homo sapiens_hsa054140.79416692
39TGF-beta signaling pathway_Homo sapiens_hsa043500.77119685
40Melanoma_Homo sapiens_hsa052180.75582932
41Sphingolipid metabolism_Homo sapiens_hsa006000.74553007
42Circadian rhythm_Homo sapiens_hsa047100.70379407
43Fatty acid biosynthesis_Homo sapiens_hsa000610.69208587
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.68661623
45N-Glycan biosynthesis_Homo sapiens_hsa005100.68618761
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67914020
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65449099
48Gastric acid secretion_Homo sapiens_hsa049710.65433123
49Oxytocin signaling pathway_Homo sapiens_hsa049210.65017407
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64926740
51Choline metabolism in cancer_Homo sapiens_hsa052310.64871040
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64747108
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64207503
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61955763
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61725742
56Prostate cancer_Homo sapiens_hsa052150.60769086
57Tight junction_Homo sapiens_hsa045300.60523343
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59938281
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59284747
60PPAR signaling pathway_Homo sapiens_hsa033200.57202978
61VEGF signaling pathway_Homo sapiens_hsa043700.56038467
62mTOR signaling pathway_Homo sapiens_hsa041500.55222701
63Wnt signaling pathway_Homo sapiens_hsa043100.53906116
64Tyrosine metabolism_Homo sapiens_hsa003500.53420278
65mRNA surveillance pathway_Homo sapiens_hsa030150.52920498
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49642463
67AMPK signaling pathway_Homo sapiens_hsa041520.48804000
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.48092690
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47406524
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46971866
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.46692856
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44146630
73Calcium signaling pathway_Homo sapiens_hsa040200.41871472
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.40936697
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40764100
76beta-Alanine metabolism_Homo sapiens_hsa004100.40706928
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40178947
78Viral carcinogenesis_Homo sapiens_hsa052030.36858275
79ABC transporters_Homo sapiens_hsa020100.35883161
80MAPK signaling pathway_Homo sapiens_hsa040100.35533869
81Axon guidance_Homo sapiens_hsa043600.34863939
82Glioma_Homo sapiens_hsa052140.34634234
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33308721
84ErbB signaling pathway_Homo sapiens_hsa040120.32871155
85Adherens junction_Homo sapiens_hsa045200.32379593
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31825546
87Insulin signaling pathway_Homo sapiens_hsa049100.31737810
88Small cell lung cancer_Homo sapiens_hsa052220.31096937
89Thyroid cancer_Homo sapiens_hsa052160.30803608
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29012641
91Non-small cell lung cancer_Homo sapiens_hsa052230.28109685
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27757679
93FoxO signaling pathway_Homo sapiens_hsa040680.27548849
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27180611
95Endocytosis_Homo sapiens_hsa041440.26790057
96Long-term potentiation_Homo sapiens_hsa047200.25907672
97Circadian entrainment_Homo sapiens_hsa047130.25030338
98Proteoglycans in cancer_Homo sapiens_hsa052050.24459528
99Basal transcription factors_Homo sapiens_hsa030220.24437296
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23720709

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