ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	binding of sperm to zona pellucida (GO:0007339)	5.91214125
2	synapsis (GO:0007129)	5.53765589
3	acrosome reaction (GO:0007340)	5.14043626
4	fusion of sperm to egg plasma membrane (GO:0007342)	5.10139323
5	chromosome condensation (GO:0030261)	5.09118688
6	sperm-egg recognition (GO:0035036)	4.94381291
7	proteasome assembly (GO:0043248)	4.93977625
8	male meiosis (GO:0007140)	4.79895355
9	DNA packaging (GO:0006323)	4.69622021
10	spermatid development (GO:0007286)	4.62743552
11	sperm motility (GO:0030317)	4.59817962
12	ribosome assembly (GO:0042255)	4.51253098
13	rRNA methylation (GO:0031167)	4.37657253
14	microtubule depolymerization (GO:0007019)	4.37431512
15	mitotic chromosome condensation (GO:0007076)	4.30045478
16	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.27137884
17	rRNA modification (GO:0000154)	4.23060574
18	multicellular organism reproduction (GO:0032504)	4.21041227
19	telomere maintenance via semi-conservative replication (GO:0032201)	4.20330024
20	chromosome organization involved in meiosis (GO:0070192)	4.17896761
21	histone exchange (GO:0043486)	4.13543275
22	DNA strand elongation involved in DNA replication (GO:0006271)	3.99454373
23	gonadal mesoderm development (GO:0007506)	3.95824696
24	nuclear pore complex assembly (GO:0051292)	3.95351607
25	DNA strand elongation (GO:0022616)	3.88118228
26	protein maturation by protein folding (GO:0022417)	3.81893794
27	cell-cell recognition (GO:0009988)	3.80675838
28	establishment of integrated proviral latency (GO:0075713)	3.79762584
29	DNA unwinding involved in DNA replication (GO:0006268)	3.70494012
30	mitotic sister chromatid segregation (GO:0000070)	3.68966340
31	regulation of centriole replication (GO:0046599)	3.66247082
32	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.66123339
33	piRNA metabolic process (GO:0034587)	3.66035253
34	plasma membrane fusion (GO:0045026)	3.65954754
35	mitotic metaphase plate congression (GO:0007080)	3.53809699
36	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.42480572
37	telomere maintenance via recombination (GO:0000722)	3.38631713
38	establishment of viral latency (GO:0019043)	3.37025914
39	nucleobase-containing small molecule interconversion (GO:0015949)	3.32062471
40	reproduction (GO:0000003)	3.31343897
41	synaptonemal complex assembly (GO:0007130)	3.25342106
42	formation of translation preinitiation complex (GO:0001731)	3.24276457
43	hepatocyte differentiation (GO:0070365)	3.23559534
44	sister chromatid segregation (GO:0000819)	3.22200602
45	de novo protein folding (GO:0006458)	3.21811306
46	nuclear pore organization (GO:0006999)	3.20783942
47	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.20632439
48	tRNA methylation (GO:0030488)	3.20168822
49	DNA synthesis involved in DNA repair (GO:0000731)	3.15459994
50	de novo posttranslational protein folding (GO:0051084)	3.15230518
51	meiotic nuclear division (GO:0007126)	3.15018755
52	ribosome biogenesis (GO:0042254)	3.14369576
53	ribosomal large subunit biogenesis (GO:0042273)	3.13816704
54	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.13096052
55	mitotic recombination (GO:0006312)	3.10482206
56	polyamine biosynthetic process (GO:0006596)	3.08389283
57	ribonucleoprotein complex biogenesis (GO:0022613)	3.07429336
58	ribosomal small subunit biogenesis (GO:0042274)	3.06988386
59	pore complex assembly (GO:0046931)	3.05878879
60	germ cell development (GO:0007281)	3.03755207
61	DNA replication initiation (GO:0006270)	3.02693888
62	regulation of meiosis I (GO:0060631)	3.02556718
63	metaphase plate congression (GO:0051310)	3.01501509
64	CENP-A containing nucleosome assembly (GO:0034080)	3.00084597
65	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.99913414
66	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.99662131
67	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.99376270
68	nucleosome disassembly (GO:0006337)	2.97669183
69	protein-DNA complex disassembly (GO:0032986)	2.97669183
70	mitotic nuclear envelope disassembly (GO:0007077)	2.97296322
71	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.93757748
72	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93185938
73	protein complex localization (GO:0031503)	2.91736180
74	folic acid metabolic process (GO:0046655)	2.88824160
75	regulation of chromosome segregation (GO:0051983)	2.88612716
76	single fertilization (GO:0007338)	2.88267861
77	telomere maintenance via telomere lengthening (GO:0010833)	2.86049836
78	negative regulation of response to reactive oxygen species (GO:1901032)	2.85746454
79	regulation of mitotic spindle organization (GO:0060236)	2.85199091
80	male gamete generation (GO:0048232)	2.84863786
81	protein localization to chromosome, centromeric region (GO:0071459)	2.84857356
82	spermatogenesis (GO:0007283)	2.84813688
83	positive regulation of ligase activity (GO:0051351)	2.84384814
84	glycolytic process (GO:0006096)	2.83031540
85	meiotic cell cycle process (GO:1903046)	2.82500873
86	DNA catabolic process, exonucleolytic (GO:0000738)	2.82490631
87	synaptonemal complex organization (GO:0070193)	2.80760422
88	negative regulation of ligase activity (GO:0051352)	2.79118554
89	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.79118554
90	nuclear envelope disassembly (GO:0051081)	2.78379989
91	membrane disassembly (GO:0030397)	2.78379989
92	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.78138145
93	oogenesis (GO:0048477)	2.76238801
94	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.76224535
95	chromosome organization (GO:0051276)	2.75820300
96	regulation of cellular respiration (GO:0043457)	2.75631934
97	chromatin remodeling at centromere (GO:0031055)	2.74661119
98	regulation of spindle organization (GO:0090224)	2.74363906
99	mitotic sister chromatid cohesion (GO:0007064)	2.74343530
100	DNA replication checkpoint (GO:0000076)	2.71210329

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.58324172
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.60916056
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.55630560
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.64877764
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59207167
6	ZNF263_19887448_ChIP-Seq_K562_Human	3.58842747
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.51040087
8	AR_21909140_ChIP-Seq_LNCAP_Human	3.08333542
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.01456938
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.89717861
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.83688941
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73848782
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.68698593
14	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.64356771
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.51288004
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.43814570
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40411758
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.39945193
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.32922488
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.29433846
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.29358389
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.27313076
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03317559
24	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.01778798
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.89300942
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.86101471
27	XRN2_22483619_ChIP-Seq_HELA_Human	1.81709293
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.81211194
29	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.79825478
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79497769
31	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.79470855
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.78049547
33	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.73406707
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.67004851
35	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.66029613
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.65910595
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.65873167
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.57379335
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.54208238
40	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.53048420
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.52092830
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49313394
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44847429
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43124395
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.42793421
46	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41853697
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41167243
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41130888
49	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.37522402
50	ATF3_27146783_Chip-Seq_COLON_Human	1.37276976
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35776204
52	KDM5A_27292631_Chip-Seq_BREAST_Human	1.35462700
53	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.32592800
54	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.26531562
55	ELF5_23300383_ChIP-Seq_T47D_Human	1.24819461
56	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.24819165
57	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.24693721
58	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.22815549
59	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.21921959
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.20576174
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.18881950
62	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.17893548
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17010752
64	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.15479640
65	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.15479640
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14154049
67	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14006776
68	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.12417742
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11374596
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.11337951
71	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10559852
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07732622
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06971763
74	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.06761362
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05736859
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04830806
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98421136
78	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.98077944
79	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97135219
80	MYC_18940864_ChIP-ChIP_HL60_Human	0.96088537
81	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96053550
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95978029
83	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.94207204
84	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.93642464
85	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.92086945
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91338598
87	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.90259343
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90129179
89	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.87945900
90	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.87833221
91	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.86875698
92	RAC3_21632823_ChIP-Seq_H3396_Human	0.85426590
93	CHD1_26751641_Chip-Seq_LNCaP_Human	0.85058192
94	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.83017999
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.82517951
96	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.80940836
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.80006332
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.79561128
99	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.78977725
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.78403415

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.02964389
2	MP0003693_abnormal_embryo_hatching	3.89145770
3	MP0002877_abnormal_melanocyte_morpholog	3.61136606
4	MP0008058_abnormal_DNA_repair	3.48570454
5	MP0004957_abnormal_blastocyst_morpholog	3.30234053
6	MP0010094_abnormal_chromosome_stability	3.14946776
7	MP0003077_abnormal_cell_cycle	3.02680450
8	MP0003950_abnormal_plasma_membrane	2.87191375
9	MP0001929_abnormal_gametogenesis	2.80727309
10	MP0003315_abnormal_perineum_morphology	2.59717782
11	MP0003111_abnormal_nucleus_morphology	2.56787256
12	MP0003786_premature_aging	2.50407157
13	MP0009697_abnormal_copulation	2.44299038
14	MP0003698_abnormal_male_reproductive	2.43178813
15	MP0003718_maternal_effect	2.38563007
16	MP0004233_abnormal_muscle_weight	2.38390689
17	MP0003806_abnormal_nucleotide_metabolis	2.21107923
18	MP0008995_early_reproductive_senescence	2.12072094
19	MP0010030_abnormal_orbit_morphology	2.11685990
20	MP0010234_abnormal_vibrissa_follicle	2.06474008
21	MP0008057_abnormal_DNA_replication	2.04774315
22	MP0002210_abnormal_sex_determination	2.03738285
23	MP0008932_abnormal_embryonic_tissue	2.02011428
24	MP0008007_abnormal_cellular_replicative	1.94586597
25	MP0005670_abnormal_white_adipose	1.89981593
26	MP0005623_abnormal_meninges_morphology	1.74104394
27	MP0002160_abnormal_reproductive_system	1.68180340
28	MP0001661_extended_life_span	1.66742078
29	MP0001145_abnormal_male_reproductive	1.61119224
30	MP0002161_abnormal_fertility/fecundity	1.60376296
31	MP0005083_abnormal_biliary_tract	1.51758237
32	MP0006036_abnormal_mitochondrial_physio	1.50535904
33	MP0005647_abnormal_sex_gland	1.47472333
34	MP0003186_abnormal_redox_activity	1.45826917
35	MP0001348_abnormal_lacrimal_gland	1.45794480
36	MP0000653_abnormal_sex_gland	1.45221011
37	MP0010352_gastrointestinal_tract_polyps	1.43309842
38	MP0010368_abnormal_lymphatic_system	1.42634921
39	MP0010307_abnormal_tumor_latency	1.41949359
40	MP0005451_abnormal_body_composition	1.34548508
41	MP0000350_abnormal_cell_proliferation	1.29292966
42	MP0002132_abnormal_respiratory_system	1.20345033
43	MP0008004_abnormal_stomach_pH	1.16832332
44	MP0005058_abnormal_lysosome_morphology	1.15574276
45	MP0000358_abnormal_cell_content/	1.15055734
46	MP0000013_abnormal_adipose_tissue	1.12995685
47	MP0002080_prenatal_lethality	1.12763886
48	MP0000490_abnormal_crypts_of	1.12652203
49	MP0005501_abnormal_skin_physiology	1.12151146
50	MP0002796_impaired_skin_barrier	1.03412297
51	MP0005395_other_phenotype	1.02545768
52	MP0000313_abnormal_cell_death	1.01541897
53	MP0006035_abnormal_mitochondrial_morpho	1.00074536
54	MP0002060_abnormal_skin_morphology	0.99973100
55	MP0001730_embryonic_growth_arrest	0.99085588
56	MP0001697_abnormal_embryo_size	0.97536700
57	MP0000537_abnormal_urethra_morphology	0.97296556
58	MP0000003_abnormal_adipose_tissue	0.92556508
59	MP0002234_abnormal_pharynx_morphology	0.92534842
60	MP0003123_paternal_imprinting	0.91736884
61	MP0000762_abnormal_tongue_morphology	0.89991604
62	MP0005165_increased_susceptibility_to	0.89463609
63	MP0000627_abnormal_mammary_gland	0.88491095
64	MP0003699_abnormal_female_reproductive	0.87805482
65	MP0005389_reproductive_system_phenotype	0.87094461
66	MP0000733_abnormal_muscle_development	0.86633676
67	MP0005360_urolithiasis	0.85393763
68	MP0001672_abnormal_embryogenesis/_devel	0.81618915
69	MP0005380_embryogenesis_phenotype	0.81618915
70	MP0005330_cardiomyopathy	0.80281335
71	MP0000749_muscle_degeneration	0.78646370
72	MP0001764_abnormal_homeostasis	0.78319316
73	MP0002166_altered_tumor_susceptibility	0.77440618
74	MP0004808_abnormal_hematopoietic_stem	0.77265845
75	MP0002019_abnormal_tumor_incidence	0.77176075
76	MP0005257_abnormal_intraocular_pressure	0.75497317
77	MP0004272_abnormal_basement_membrane	0.75034850
78	MP0003566_abnormal_cell_adhesion	0.74471562
79	MP0002006_tumorigenesis	0.73630826
80	MP0002282_abnormal_trachea_morphology	0.73432424
81	MP0002086_abnormal_extraembryonic_tissu	0.71989080
82	MP0008877_abnormal_DNA_methylation	0.69326320
83	MP0005197_abnormal_uvea_morphology	0.68717541
84	MP0001340_abnormal_eyelid_morphology	0.65851011
85	MP0003984_embryonic_growth_retardation	0.65533556
86	MP0003453_abnormal_keratinocyte_physiol	0.65213981
87	MP0000516_abnormal_urinary_system	0.65007409
88	MP0005367_renal/urinary_system_phenotyp	0.65007409
89	MP0005384_cellular_phenotype	0.64668245
90	MP0005621_abnormal_cell_physiology	0.64589741
91	MP0002088_abnormal_embryonic_growth/wei	0.63485645
92	MP0001216_abnormal_epidermal_layer	0.63156123
93	MP0005332_abnormal_amino_acid	0.62357035
94	MP0010678_abnormal_skin_adnexa	0.62029389
95	MP0002332_abnormal_exercise_endurance	0.61653427
96	MP0001853_heart_inflammation	0.60992820
97	MP0003936_abnormal_reproductive_system	0.60327312
98	MP0000678_abnormal_parathyroid_gland	0.59929606
99	MP0000343_altered_response_to	0.59587790
100	MP0004782_abnormal_surfactant_physiolog	0.59505934

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the preputium (HP:0100587)	4.25659513
2	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.20262067
3	Sensory axonal neuropathy (HP:0003390)	4.03366011
4	Resting tremor (HP:0002322)	3.95635878
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.86192254
6	Reduced antithrombin III activity (HP:0001976)	3.71034735
7	Meckel diverticulum (HP:0002245)	3.56268272
8	Chromsome breakage (HP:0040012)	3.51657184
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.51403235
10	Abnormality of the ileum (HP:0001549)	3.47214599
11	Abnormality of chromosome stability (HP:0003220)	3.14925889
12	Short nail (HP:0001799)	3.10417238
13	Cerebellar dysplasia (HP:0007033)	3.01399383
14	Small intestinal stenosis (HP:0012848)	2.98582593
15	Duodenal stenosis (HP:0100867)	2.98582593
16	Hypoplasia of the uterus (HP:0000013)	2.98147537
17	Squamous cell carcinoma (HP:0002860)	2.91768544
18	Osteolytic defects of the hand bones (HP:0009699)	2.81964547
19	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.81964547
20	Proximal placement of thumb (HP:0009623)	2.79812467
21	Deviation of the thumb (HP:0009603)	2.78805920
22	Cutaneous melanoma (HP:0012056)	2.71782665
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.70320095
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.70320095
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.62286704
26	Absent thumb (HP:0009777)	2.60306965
27	Cerebral edema (HP:0002181)	2.59503681
28	Microglossia (HP:0000171)	2.58323072
29	Reduced subcutaneous adipose tissue (HP:0003758)	2.57124986
30	Sparse eyelashes (HP:0000653)	2.46547070
31	Abnormality of the intrinsic pathway (HP:0010989)	2.43179047
32	Entropion (HP:0000621)	2.40510730
33	Flattened epiphyses (HP:0003071)	2.38869090
34	Hepatocellular necrosis (HP:0001404)	2.37652931
35	Abnormality of the carotid arteries (HP:0005344)	2.35520277
36	Clubbing of toes (HP:0100760)	2.34523577
37	Type I transferrin isoform profile (HP:0003642)	2.30710613
38	Retinal dysplasia (HP:0007973)	2.26555814
39	Small epiphyses (HP:0010585)	2.25872215
40	Ureteral duplication (HP:0000073)	2.23997954
41	Abnormality of the umbilical cord (HP:0010881)	2.23501354
42	Abnormal protein glycosylation (HP:0012346)	2.23381752
43	Abnormal glycosylation (HP:0012345)	2.23381752
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.23381752
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.23381752
46	Male infertility (HP:0003251)	2.19221897
47	Abnormal auditory evoked potentials (HP:0006958)	2.17561620
48	Sparse lateral eyebrow (HP:0005338)	2.16254848
49	Severe visual impairment (HP:0001141)	2.15746811
50	Infertility (HP:0000789)	2.13142784
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11947870
52	Abnormality of the distal phalanges of the toes (HP:0010182)	2.10725432
53	Renal Fanconi syndrome (HP:0001994)	2.10663428
54	Abnormality of pyrimidine metabolism (HP:0004353)	2.10305496
55	Abnormality of glycolysis (HP:0004366)	2.09993195
56	Abnormality of the duodenum (HP:0002246)	2.08696456
57	Abnormalities of placenta or umbilical cord (HP:0001194)	2.06731588
58	Horizontal nystagmus (HP:0000666)	2.06573144
59	Rough bone trabeculation (HP:0100670)	2.06390080
60	Absent radius (HP:0003974)	2.06109816
61	Elbow flexion contracture (HP:0002987)	2.05987288
62	Congenital, generalized hypertrichosis (HP:0004540)	2.05245352
63	Abnormality of alanine metabolism (HP:0010916)	2.04705600
64	Hyperalaninemia (HP:0003348)	2.04705600
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04705600
66	Rhabdomyolysis (HP:0003201)	2.03844262
67	Abnormal spermatogenesis (HP:0008669)	2.03436981
68	Fibular aplasia (HP:0002990)	2.02659149
69	Secondary amenorrhea (HP:0000869)	2.01777163
70	Hypobetalipoproteinemia (HP:0003563)	2.00756476
71	Vertebral compression fractures (HP:0002953)	1.99169358
72	Acute necrotizing encephalopathy (HP:0006965)	1.97902733
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.96480773
74	Amniotic constriction ring (HP:0009775)	1.94953584
75	Abnormality of placental membranes (HP:0011409)	1.94953584
76	Hypergonadotropic hypogonadism (HP:0000815)	1.93859008
77	Myelodysplasia (HP:0002863)	1.93576452
78	Increased CSF lactate (HP:0002490)	1.92171350
79	Upper limb muscle weakness (HP:0003484)	1.92078473
80	Acute encephalopathy (HP:0006846)	1.90599353
81	Deep philtrum (HP:0002002)	1.88732261
82	Horseshoe kidney (HP:0000085)	1.88129744
83	Absent forearm bone (HP:0003953)	1.87249559
84	Aplasia involving forearm bones (HP:0009822)	1.87249559
85	Spastic paraparesis (HP:0002313)	1.86791736
86	Sex reversal (HP:0012245)	1.84962126
87	Abnormal sex determination (HP:0012244)	1.84962126
88	Hepatic necrosis (HP:0002605)	1.83596332
89	Lipid accumulation in hepatocytes (HP:0006561)	1.83173641
90	Reticulocytopenia (HP:0001896)	1.82848317
91	Abnormality of DNA repair (HP:0003254)	1.82396295
92	Mitochondrial inheritance (HP:0001427)	1.82373842
93	Microvesicular hepatic steatosis (HP:0001414)	1.81950045
94	Volvulus (HP:0002580)	1.81700794
95	Progressive muscle weakness (HP:0003323)	1.79765958
96	Myoglobinuria (HP:0002913)	1.79206630
97	Abnormal trabecular bone morphology (HP:0100671)	1.77174399
98	Absent epiphyses (HP:0010577)	1.76715881
99	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.76715881
100	Bifid uvula (HP:0000193)	1.76427822

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	5.50088797
2	NME2	3.50926524
3	ZAK	3.03923625
4	PDK2	2.94034073
5	EPHA2	2.67983012
6	BUB1	2.61250202
7	EIF2AK1	2.60833370
8	TESK1	2.59527687
9	PBK	2.43568760
10	EIF2AK3	2.37924750
11	PINK1	2.34894310
12	STK16	2.28981087
13	MET	2.23168052
14	TLK1	2.14512159
15	IRAK3	2.10503120
16	SRPK1	2.09017152
17	PLK4	1.98264367
18	ARAF	1.97415440
19	NEK1	1.94574858
20	TTK	1.83859868
21	BRSK2	1.80021747
22	MARK3	1.76103883
23	SCYL2	1.76047764
24	BRSK1	1.72333121
25	VRK2	1.54269237
26	WEE1	1.40449227
27	CDC7	1.39419953
28	TESK2	1.39057711
29	RPS6KA5	1.36862607
30	CDK8	1.30636919
31	BRAF	1.29939852
32	MAP3K12	1.29206840
33	CCNB1	1.26863071
34	NEK2	1.26362918
35	MYLK	1.20906401
36	AURKB	1.19269228
37	ERBB4	1.12869680
38	LATS2	1.12290605
39	PLK1	1.08640873
40	AURKA	1.05578190
41	PAK4	1.03567560
42	BMPR2	1.01699183
43	STK38L	1.01654217
44	PNCK	0.99739252
45	MOS	0.99535767
46	STK39	0.98397804
47	NEK6	0.90714409
48	TRIM28	0.90643266
49	MAP3K9	0.90300748
50	WNK4	0.90261843
51	VRK1	0.89121487
52	NME1	0.88143399
53	LIMK1	0.85966063
54	STK10	0.82302404
55	MAP3K8	0.81300743
56	CHEK2	0.81214024
57	STK38	0.80744504
58	PIM2	0.80591267
59	RPS6KB2	0.79717995
60	CDK7	0.79540588
61	TAOK2	0.78428317
62	MST4	0.75664867
63	ATR	0.73294222
64	TSSK6	0.73246399
65	ABL2	0.71676133
66	ILK	0.67753441
67	LATS1	0.67242659
68	PLK3	0.65599264
69	PAK1	0.64707540
70	MAP2K7	0.59927693
71	LMTK2	0.59875263
72	ERBB3	0.53224015
73	ICK	0.51920825
74	DAPK1	0.51245470
75	AKT2	0.48935782
76	EIF2AK2	0.47313141
77	CHEK1	0.46914030
78	OXSR1	0.45995617
79	RAF1	0.44435508
80	PRKCI	0.42223229
81	INSRR	0.41140035
82	PTK2	0.40612026
83	PDPK1	0.39811056
84	CDK3	0.36870848
85	CLK1	0.36193943
86	CDK19	0.36142117
87	STK3	0.35160965
88	MELK	0.35132455
89	SIK3	0.31088574
90	ATM	0.29702118
91	MAPKAPK5	0.28118536
92	MTOR	0.26667398
93	MKNK1	0.26301955
94	CSNK2A2	0.26135556
95	CDK1	0.26035189
96	MAPK11	0.25396632
97	MUSK	0.25147197
98	BMPR1B	0.21985505
99	DAPK3	0.20491012
100	CSNK1G3	0.19802430

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.69894819
2	Mismatch repair_Homo sapiens_hsa03430	3.65210236
3	Proteasome_Homo sapiens_hsa03050	3.56687768
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.53963173
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.78951760
6	Ribosome_Homo sapiens_hsa03010	2.75967682
7	RNA transport_Homo sapiens_hsa03013	2.68299668
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.63700402
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.39023667
10	Base excision repair_Homo sapiens_hsa03410	2.28643341
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.24867486
12	Homologous recombination_Homo sapiens_hsa03440	2.16918525
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.16174597
14	Folate biosynthesis_Homo sapiens_hsa00790	2.14595459
15	Cell cycle_Homo sapiens_hsa04110	2.13265013
16	Non-homologous end-joining_Homo sapiens_hsa03450	2.08149353
17	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.05044743
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.03681736
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99101160
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.92739719
21	RNA polymerase_Homo sapiens_hsa03020	1.74213857
22	Alcoholism_Homo sapiens_hsa05034	1.72271233
23	Spliceosome_Homo sapiens_hsa03040	1.67756257
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.59848285
25	Basal transcription factors_Homo sapiens_hsa03022	1.48971167
26	Carbon metabolism_Homo sapiens_hsa01200	1.48832893
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.48800843
28	Purine metabolism_Homo sapiens_hsa00230	1.48119209
29	Huntingtons disease_Homo sapiens_hsa05016	1.43585014
30	RNA degradation_Homo sapiens_hsa03018	1.42730942
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.42268590
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.39550947
33	Parkinsons disease_Homo sapiens_hsa05012	1.36850278
34	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.27061971
35	Sulfur relay system_Homo sapiens_hsa04122	1.23439410
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17210485
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.14119783
38	Oocyte meiosis_Homo sapiens_hsa04114	1.13367855
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.10891320
40	Glutathione metabolism_Homo sapiens_hsa00480	1.08664956
41	One carbon pool by folate_Homo sapiens_hsa00670	1.06649880
42	Apoptosis_Homo sapiens_hsa04210	1.05710786
43	Alzheimers disease_Homo sapiens_hsa05010	1.01671286
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00850834
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.92349047
46	Galactose metabolism_Homo sapiens_hsa00052	0.89309802
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89206495
48	Protein export_Homo sapiens_hsa03060	0.86952617
49	Gap junction_Homo sapiens_hsa04540	0.85408358
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.83141494
51	Viral carcinogenesis_Homo sapiens_hsa05203	0.81360584
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.80345559
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79691660
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79662694
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77323319
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76776644
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75686303
58	p53 signaling pathway_Homo sapiens_hsa04115	0.75430826
59	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75229778
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68473657
61	Fatty acid elongation_Homo sapiens_hsa00062	0.66983993
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.66403416
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62006941
64	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.60144475
65	Olfactory transduction_Homo sapiens_hsa04740	0.58599775
66	Metabolic pathways_Homo sapiens_hsa01100	0.57204758
67	Propanoate metabolism_Homo sapiens_hsa00640	0.57157454
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56047508
69	Bladder cancer_Homo sapiens_hsa05219	0.54505926
70	Circadian rhythm_Homo sapiens_hsa04710	0.49637697
71	Small cell lung cancer_Homo sapiens_hsa05222	0.43914721
72	Viral myocarditis_Homo sapiens_hsa05416	0.41013617
73	Herpes simplex infection_Homo sapiens_hsa05168	0.38700346
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37646371
75	Thyroid cancer_Homo sapiens_hsa05216	0.34625472
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34432944
77	Phagosome_Homo sapiens_hsa04145	0.34085155
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34000126
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.30391843
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.27948652
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.27490539
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.26791000
83	Legionellosis_Homo sapiens_hsa05134	0.25734033
84	HTLV-I infection_Homo sapiens_hsa05166	0.25589518
85	Influenza A_Homo sapiens_hsa05164	0.23786875
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.20972380
87	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.18749099
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.17169700
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17139454
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.14147622
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.13788510
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.13366072
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.12904280
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.11315500
95	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.09924097
96	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.08333710
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.07747083
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.07731184
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.06400536
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.04051527

CT83

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »