CTAG1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.15954333
2ribosomal small subunit biogenesis (GO:0042274)7.90287102
3formation of translation preinitiation complex (GO:0001731)6.92244192
4viral transcription (GO:0019083)6.50153816
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)6.34142260
6melanin biosynthetic process (GO:0042438)6.13592599
7translational termination (GO:0006415)6.10714150
8melanin metabolic process (GO:0006582)5.67493431
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.57619526
10translational elongation (GO:0006414)5.51737934
11protein targeting to ER (GO:0045047)5.42561502
12cotranslational protein targeting to membrane (GO:0006613)5.40968172
13protein localization to endoplasmic reticulum (GO:0070972)5.19529682
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19441332
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.12651124
16translational initiation (GO:0006413)5.09705967
17viral life cycle (GO:0019058)5.05024231
18ribosomal large subunit biogenesis (GO:0042273)4.99300639
19secondary metabolite biosynthetic process (GO:0044550)4.78453181
20cellular protein complex disassembly (GO:0043624)4.76306625
21ribonucleoprotein complex biogenesis (GO:0022613)4.73928264
22regulation of mammary gland epithelial cell proliferation (GO:0033599)4.39892481
23protein complex disassembly (GO:0043241)4.27897129
24macromolecular complex disassembly (GO:0032984)4.10375584
25mitochondrial fusion (GO:0008053)4.09145411
26protein targeting to membrane (GO:0006612)4.06618278
27COPI coating of Golgi vesicle (GO:0048205)4.06396806
28Golgi transport vesicle coating (GO:0048200)4.06396806
29T cell apoptotic process (GO:0070231)3.94105930
30translation (GO:0006412)3.89322899
31protein maturation by protein folding (GO:0022417)3.82794008
32rRNA modification (GO:0000154)3.66783013
33ribosome biogenesis (GO:0042254)3.64178909
34ribosome assembly (GO:0042255)3.41688382
35mesenchyme development (GO:0060485)3.39024172
36lymphocyte apoptotic process (GO:0070227)3.38896804
37cellular component biogenesis (GO:0044085)3.37532089
38maturation of SSU-rRNA (GO:0030490)3.37336101
39mesoderm development (GO:0007498)3.36884605
40mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.36269537
41regulation of protein heterodimerization activity (GO:0043497)3.33851731
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.30727601
43response to gravity (GO:0009629)3.29207735
44regulation of translational fidelity (GO:0006450)3.26575840
45nucleobase-containing small molecule interconversion (GO:0015949)3.17718631
46guanosine-containing compound biosynthetic process (GO:1901070)3.15818735
47regulation of growth hormone secretion (GO:0060123)3.15716790
48positive regulation of growth hormone secretion (GO:0060124)3.15331144
49mRNA catabolic process (GO:0006402)3.15268049
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.11003143
51termination of RNA polymerase III transcription (GO:0006386)3.11003143
52endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.08948309
53establishment of protein localization to membrane (GO:0090150)3.03958911
54negative regulation of necroptotic process (GO:0060546)3.01221003
55protein targeting to mitochondrion (GO:0006626)3.00930530
56gonadal mesoderm development (GO:0007506)23.4509018
57establishment of protein localization to mitochondrion (GO:0072655)2.99802551
58activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.93618525
59myeloid cell homeostasis (GO:0002262)2.93419076
60protein insertion into membrane (GO:0051205)2.92789004
61GMP metabolic process (GO:0046037)2.92668103
62nuclear envelope reassembly (GO:0031468)2.90431453
63mitotic nuclear envelope reassembly (GO:0007084)2.90431453
64tyrosine metabolic process (GO:0006570)2.89582859
65RNA catabolic process (GO:0006401)2.89332018
66protein targeting (GO:0006605)2.86718470
67negative regulation of catenin import into nucleus (GO:0035414)2.86477330
68rRNA methylation (GO:0031167)2.84774842
69regulation of gonadotropin secretion (GO:0032276)2.80919966
70positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80396855
71modulation by virus of host process (GO:0019054)2.79981356
72negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.79076611
73amyloid precursor protein catabolic process (GO:0042987)2.78582262
74rRNA processing (GO:0006364)2.74998892
75GDP-mannose metabolic process (GO:0019673)2.69078361
76peptidyl-histidine modification (GO:0018202)2.68320470
77leukocyte apoptotic process (GO:0071887)2.62900347
78pinocytosis (GO:0006907)2.62746701
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61515950
80establishment of protein localization to organelle (GO:0072594)2.60962154
81protein localization to mitochondrion (GO:0070585)2.60201120
82intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.60108305
83rRNA metabolic process (GO:0016072)2.56591519
84negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.55735075
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.55638951
86negative regulation of cell size (GO:0045792)2.54269646
87positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.51813982
88enteric nervous system development (GO:0048484)2.51748964
89establishment of integrated proviral latency (GO:0075713)2.49863935
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47352162
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47313387
92regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.46892790
93aerobic respiration (GO:0009060)2.46540838
94regulation of translational initiation (GO:0006446)2.46320991
95viral protein processing (GO:0019082)2.45232876
96regulation of early endosome to late endosome transport (GO:2000641)2.44788147
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41754103
98protein localization to membrane (GO:0072657)2.41334484
99UTP biosynthetic process (GO:0006228)2.40534353
100ribonucleoprotein complex assembly (GO:0022618)2.40488629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74799684
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.67369152
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39992643
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.33032558
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97095278
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.85341228
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65395349
8XRN2_22483619_ChIP-Seq_HELA_Human2.65082912
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58755455
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41841247
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37086169
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31601731
13TTF2_22483619_ChIP-Seq_HELA_Human2.28800242
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26295955
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24024646
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22926155
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17199731
18DCP1A_22483619_ChIP-Seq_HELA_Human2.11398230
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06860700
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05395153
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.04999595
22GABP_19822575_ChIP-Seq_HepG2_Human1.99518176
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.98757911
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91303302
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.87558286
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.86139290
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85175098
28ZNF263_19887448_ChIP-Seq_K562_Human1.83853444
29MYC_22102868_ChIP-Seq_BL_Human1.81341531
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78604925
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77881061
32RACK7_27058665_Chip-Seq_MCF-7_Human1.75624443
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75617753
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73725922
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66539858
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65811406
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65197524
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64332241
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64020416
40TFEB_21752829_ChIP-Seq_HELA_Human1.63733753
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60646253
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59028281
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.58541413
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57518207
45LXR_22292898_ChIP-Seq_THP-1_Human1.51388451
46VDR_21846776_ChIP-Seq_THP-1_Human1.50799903
47KDM5A_27292631_Chip-Seq_BREAST_Human1.50255421
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48785582
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.48564438
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47781418
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46683412
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44377270
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.42303927
54ATF3_27146783_Chip-Seq_COLON_Human1.40940290
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40176210
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38311253
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37797812
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35748097
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35615472
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33317982
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33138781
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31299356
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30963215
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29628437
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28806561
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27261331
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26988839
68VDR_23849224_ChIP-Seq_CD4+_Human1.26611564
69MAF_26560356_Chip-Seq_TH2_Human1.25479657
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24807589
71FOXP3_21729870_ChIP-Seq_TREG_Human1.22446073
72CIITA_25753668_ChIP-Seq_RAJI_Human1.21826451
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21563133
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21283114
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19949603
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19694597
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16678455
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16677639
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16131676
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13683358
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13502950
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13271567
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11702573
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.11668413
85TP53_22127205_ChIP-Seq_IMR90_Human1.10360152
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.09880893
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09731755
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.08497626
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.07786822
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.07585498
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07297798
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06999935
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06998323
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02900070
95TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02636416
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02249540
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02105600
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02002421
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01614159
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.99903332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.33242870
2MP0003136_yellow_coat_color4.82885892
3MP0005408_hypopigmentation3.82595410
4MP0005451_abnormal_body_composition3.62940966
5MP0010030_abnormal_orbit_morphology3.54240728
6MP0009379_abnormal_foot_pigmentation3.11351204
7MP0001661_extended_life_span2.84698444
8MP0002877_abnormal_melanocyte_morpholog2.71794567
9MP0000372_irregular_coat_pigmentation2.55102253
10MP0000358_abnormal_cell_content/2.42917271
11MP0000015_abnormal_ear_pigmentation2.32269088
12MP0004381_abnormal_hair_follicle2.30972268
13MP0005174_abnormal_tail_pigmentation2.24566392
14MP0008438_abnormal_cutaneous_collagen2.23116141
15MP0001348_abnormal_lacrimal_gland2.19712129
16MP0002095_abnormal_skin_pigmentation2.12281702
17MP0002075_abnormal_coat/hair_pigmentati2.04626905
18MP0006035_abnormal_mitochondrial_morpho1.98520672
19MP0001186_pigmentation_phenotype1.91461298
20MP0004233_abnormal_muscle_weight1.81723447
21MP0008007_abnormal_cellular_replicative1.78173840
22MP0005075_abnormal_melanosome_morpholog1.75715441
23MP0003693_abnormal_embryo_hatching1.68658048
24MP0005058_abnormal_lysosome_morphology1.68160832
25MP0004858_abnormal_nervous_system1.56382267
26MP0000371_diluted_coat_color1.54735292
27MP0003077_abnormal_cell_cycle1.52979049
28MP0004957_abnormal_blastocyst_morpholog1.49482316
29MP0000750_abnormal_muscle_regeneration1.46393658
30MP0003111_abnormal_nucleus_morphology1.43959779
31MP0000733_abnormal_muscle_development1.42913780
32MP0008932_abnormal_embryonic_tissue1.42569984
33MP0005501_abnormal_skin_physiology1.38043515
34MP0002938_white_spotting1.36087788
35MP0009697_abnormal_copulation1.35484116
36MP0000350_abnormal_cell_proliferation1.35084263
37MP0002089_abnormal_postnatal_growth/wei1.33491332
38MP0003786_premature_aging1.32723708
39MP0008058_abnormal_DNA_repair1.28141653
40MP0000534_abnormal_ureter_morphology1.27009094
41MP0009840_abnormal_foam_cell1.21810315
42MP0003186_abnormal_redox_activity1.21765780
43MP0005197_abnormal_uvea_morphology1.20603386
44MP0000639_abnormal_adrenal_gland1.17783133
45MP0000759_abnormal_skeletal_muscle1.12909613
46MP0002796_impaired_skin_barrier1.12315461
47MP0000858_altered_metastatic_potential1.05414579
48MP0009250_abnormal_appendicular_skeleto1.02601650
49MP0002932_abnormal_joint_morphology1.02305158
50MP0009333_abnormal_splenocyte_physiolog1.00436272
51MP0002060_abnormal_skin_morphology0.98289511
52MP0005670_abnormal_white_adipose0.95666292
53MP0002163_abnormal_gland_morphology0.94346071
54MP0005384_cellular_phenotype0.93606483
55MP0001324_abnormal_eye_pigmentation0.91961479
56MP0009053_abnormal_anal_canal0.91069188
57MP0008789_abnormal_olfactory_epithelium0.90941049
58MP0002080_prenatal_lethality0.90107540
59MP0000313_abnormal_cell_death0.90027104
60MP0003385_abnormal_body_wall0.84485278
61MP0000003_abnormal_adipose_tissue0.84159777
62MP0001730_embryonic_growth_arrest0.84106324
63MP0005257_abnormal_intraocular_pressure0.83278344
64MP0009672_abnormal_birth_weight0.82174871
65MP0010368_abnormal_lymphatic_system0.80673198
66MP0000343_altered_response_to0.77808924
67MP0002114_abnormal_axial_skeleton0.76815663
68MP0006036_abnormal_mitochondrial_physio0.75186278
69MP0003959_abnormal_lean_body0.74878865
70MP0003221_abnormal_cardiomyocyte_apopto0.74530732
71MP0004043_abnormal_pH_regulation0.73724993
72MP0005666_abnormal_adipose_tissue0.73459636
73MP0003091_abnormal_cell_migration0.72644722
74MP0005621_abnormal_cell_physiology0.72546443
75MP0003453_abnormal_keratinocyte_physiol0.71186706
76MP0003303_peritoneal_inflammation0.69937479
77MP0002210_abnormal_sex_determination0.69454169
78MP0005508_abnormal_skeleton_morphology0.68926790
79MP0005375_adipose_tissue_phenotype0.68630524
80MP0008260_abnormal_autophagy0.67787255
81MP0005193_abnormal_anterior_eye0.66390486
82MP0002113_abnormal_skeleton_development0.66185074
83MP0004808_abnormal_hematopoietic_stem0.64648524
84MP0001697_abnormal_embryo_size0.64511743
85MP0004185_abnormal_adipocyte_glucose0.64243235
86MP0000747_muscle_weakness0.63946411
87MP0005330_cardiomyopathy0.62480450
88MP0010771_integument_phenotype0.58480727
89MP0002751_abnormal_autonomic_nervous0.57264539
90MP0005623_abnormal_meninges_morphology0.55751620
91MP0000678_abnormal_parathyroid_gland0.55347571
92MP0003634_abnormal_glial_cell0.53957083
93MP0005248_abnormal_Harderian_gland0.53925101
94MP0002085_abnormal_embryonic_tissue0.52292621
95MP0002896_abnormal_bone_mineralization0.51597408
96MP0001145_abnormal_male_reproductive0.50486197
97MP0002019_abnormal_tumor_incidence0.49624169
98MP0001944_abnormal_pancreas_morphology0.48962122
99MP0002269_muscular_atrophy0.48814576
100MP0008770_decreased_survivor_rate0.47909863

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)6.42996962
2Spastic paraparesis (HP:0002313)5.79217308
3White forelock (HP:0002211)5.51453160
4Patchy hypopigmentation of hair (HP:0011365)5.42061757
5Abnormality of cells of the erythroid lineage (HP:0012130)4.87803173
6Syringomyelia (HP:0003396)4.64439375
7Spinal cord lesions (HP:0100561)4.64439375
8Premature graying of hair (HP:0002216)4.13441582
9Abnormal number of erythroid precursors (HP:0012131)4.04639739
10Hypoproteinemia (HP:0003075)4.02159369
11Paraparesis (HP:0002385)4.01327480
12Cerebral hypomyelination (HP:0006808)4.00599159
13Protrusio acetabuli (HP:0003179)3.63650499
14Trismus (HP:0000211)3.54953094
15Upper limb muscle weakness (HP:0003484)3.53288970
16Heterochromia iridis (HP:0001100)3.42564411
17Abnormality of the distal phalanges of the toes (HP:0010182)3.32134730
18Hypopigmentation of the fundus (HP:0007894)3.08370015
19Distal lower limb muscle weakness (HP:0009053)3.04744614
20Achilles tendon contracture (HP:0001771)3.02939013
21Abnormal auditory evoked potentials (HP:0006958)2.97396492
22Blue irides (HP:0000635)2.94080465
23Cutaneous melanoma (HP:0012056)2.87559302
24Reticulocytopenia (HP:0001896)2.81901601
25Entropion (HP:0000621)2.73393767
26Multiple lipomas (HP:0001012)2.68006665
27Ocular albinism (HP:0001107)2.62246999
28Abnormality of the Achilles tendon (HP:0005109)2.59931126
29Abnormal autonomic nervous system physiology (HP:0012332)2.58537473
30Rough bone trabeculation (HP:0100670)2.57790197
31CNS hypomyelination (HP:0003429)2.53752316
32Male infertility (HP:0003251)2.50075063
33Macrocytic anemia (HP:0001972)2.46643060
34Premature rupture of membranes (HP:0001788)2.42894058
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39772672
36Abnormality of the umbilical cord (HP:0010881)2.38419217
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38217394
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38217394
39Sensory axonal neuropathy (HP:0003390)2.35959436
40Elbow flexion contracture (HP:0002987)2.35049982
41Delayed cranial suture closure (HP:0000270)2.33955017
42Albinism (HP:0001022)2.33753408
43Reduced subcutaneous adipose tissue (HP:0003758)2.32677889
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.32668102
45Osteolytic defects of the hand bones (HP:0009699)2.32668102
46Distal lower limb amyotrophy (HP:0008944)2.29725426
47Hand muscle atrophy (HP:0009130)2.25678807
48Fatigue (HP:0012378)2.23575789
49Generalized hypopigmentation (HP:0007513)2.22255880
50Large for gestational age (HP:0001520)2.21324410
51Nuclear cataract (HP:0100018)2.16872219
52Short nail (HP:0001799)2.16770933
53Down-sloping shoulders (HP:0200021)2.15369571
54Iris hypopigmentation (HP:0007730)2.13466094
55Hyperparathyroidism (HP:0000843)2.12792325
56Distal upper limb amyotrophy (HP:0007149)2.09971441
57Upper limb amyotrophy (HP:0009129)2.09971441
58Peripheral hypomyelination (HP:0007182)2.09795771
59Deep palmar crease (HP:0006191)2.09712086
60Abnormal umbilical cord blood vessels (HP:0011403)2.07392464
61Single umbilical artery (HP:0001195)2.07392464
62Abnormality of the fetal cardiovascular system (HP:0010948)2.07392464
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06283312
64Abnormal trabecular bone morphology (HP:0100671)2.03205911
65Microretrognathia (HP:0000308)2.01174964
66Long palpebral fissure (HP:0000637)2.00485753
67Progressive muscle weakness (HP:0003323)1.98876169
68Neoplasm of head and neck (HP:0012288)1.97547039
69Esophageal neoplasm (HP:0100751)1.97547039
70Conjunctival hamartoma (HP:0100780)1.94220119
71Foot dorsiflexor weakness (HP:0009027)1.92494078
72Abnormality of subcutaneous fat tissue (HP:0001001)1.87226662
73Type I transferrin isoform profile (HP:0003642)1.86421667
74Melanoma (HP:0002861)1.85278229
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80657843
76Spinal cord compression (HP:0002176)1.80430451
77Rectal prolapse (HP:0002035)1.79806622
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79191536
79Decreased subcutaneous fat (HP:0001002)1.78278841
80Wormian bones (HP:0002645)1.77253663
81Glossoptosis (HP:0000162)1.76269444
82Ragged-red muscle fibers (HP:0003200)1.75249109
83Myopathic facies (HP:0002058)1.74892456
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74262334
85Increased connective tissue (HP:0009025)1.74175221
86Abnormalities of placenta or umbilical cord (HP:0001194)1.73557379
87Broad distal phalanx of finger (HP:0009836)1.73539144
88Sparse eyelashes (HP:0000653)1.73392696
89Breech presentation (HP:0001623)1.71141077
90Short clavicles (HP:0000894)1.69370782
91Pallor (HP:0000980)1.69355147
92Alacrima (HP:0000522)1.67661621
93Poikiloderma (HP:0001029)1.67332058
94Erythema (HP:0010783)1.67168345
95Distal sensory impairment (HP:0002936)1.66321613
96Testicular atrophy (HP:0000029)1.65993147
97Sparse lateral eyebrow (HP:0005338)1.65727007
98Round ear (HP:0100830)1.63304349
99Limb-girdle muscle atrophy (HP:0003797)1.63230237
100Coxa vara (HP:0002812)1.62890741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.73937510
2IRAK35.00496431
3EPHA23.20691616
4PRPF4B2.99619486
5TRIB32.82143849
6PAK42.57324603
7RPS6KB22.56151784
8ARAF2.54788797
9TAOK22.54208001
10LMTK22.49260654
11MOS2.45555397
12PRKD32.03335914
13BRAF1.97430378
14ERN11.83736077
15EEF2K1.81177813
16BUB11.77645609
17ILK1.71059684
18EIF2AK31.69027053
19IRAK41.67124845
20IRAK21.65748099
21PAK61.58147333
22SCYL21.53994641
23FLT31.53429528
24CDK191.49386886
25TESK21.47920950
26STK161.43174717
27PIM21.39572733
28VRK21.38450401
29ICK1.36355304
30LRRK21.30074702
31NTRK11.22164595
32NEK11.20286328
33MAPKAPK31.19694816
34PAK21.16089493
35DDR21.15610099
36SIK31.15154234
37TESK11.14207866
38SIK11.13491521
39PRKD21.09874926
40ABL21.00050304
41MAP3K110.96996876
42DYRK30.91793907
43MAP3K90.91202993
44AKT20.91032597
45MET0.90365521
46MARK20.89275998
47MARK30.89195136
48KSR20.86211661
49EPHB10.85069480
50PAK10.83031320
51NEK20.82015448
52BCKDK0.79378046
53PDPK10.78938762
54LATS20.78021825
55CDK80.77588340
56CDK30.77291591
57PKN20.71479123
58PTK20.69598382
59PDGFRA0.65369607
60AKT30.64306188
61CDK70.63822445
62PASK0.62042601
63DAPK10.61439881
64ZAP700.60937076
65IRAK10.60683244
66CDK11A0.59764455
67MAP3K80.59111581
68PRKCI0.56072535
69BRSK10.55571211
70ERBB30.54881352
71MAP3K30.54262720
72MAP2K30.51050684
73ERBB40.51008319
74MAP3K130.49076230
75GSK3A0.48965357
76LIMK10.48510582
77SIK20.46920693
78CDK150.45440246
79RPS6KL10.45361415
80RPS6KC10.45361415
81AURKA0.44135148
82MAPKAPK20.42916255
83RAF10.42518028
84CDK180.41579828
85MTOR0.40329613
86CDK140.37977548
87MAP3K10.36889581
88CHEK20.35611428
89DAPK30.35575860
90ROCK20.35554557
91DMPK0.33640410
92PHKG10.33116370
93PHKG20.33116370
94MAP2K20.32320221
95BMPR20.32196667
96TGFBR10.31995695
97RPS6KA60.31967027
98WEE10.31447310
99RPS6KA40.31011483
100CDK60.29759269

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.30128472
2Sulfur relay system_Homo sapiens_hsa041223.88371504
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77070654
4RNA polymerase_Homo sapiens_hsa030202.73639386
5Pyrimidine metabolism_Homo sapiens_hsa002402.49097411
6Proteasome_Homo sapiens_hsa030502.26495423
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18468213
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.02896129
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99069275
10Base excision repair_Homo sapiens_hsa034101.98314836
11N-Glycan biosynthesis_Homo sapiens_hsa005101.82485224
12Spliceosome_Homo sapiens_hsa030401.69209606
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62740976
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61744412
15Oxidative phosphorylation_Homo sapiens_hsa001901.60962528
16Parkinsons disease_Homo sapiens_hsa050121.59594345
17RNA transport_Homo sapiens_hsa030131.52044668
18Prion diseases_Homo sapiens_hsa050201.51110640
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48494720
20DNA replication_Homo sapiens_hsa030301.46261284
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46260032
22Huntingtons disease_Homo sapiens_hsa050161.44282317
23Nucleotide excision repair_Homo sapiens_hsa034201.43942277
24Selenocompound metabolism_Homo sapiens_hsa004501.42547245
25Folate biosynthesis_Homo sapiens_hsa007901.38210103
26Pentose phosphate pathway_Homo sapiens_hsa000301.32140129
27Biosynthesis of amino acids_Homo sapiens_hsa012301.29234528
28Purine metabolism_Homo sapiens_hsa002301.27485395
29Chronic myeloid leukemia_Homo sapiens_hsa052201.26209954
30Alzheimers disease_Homo sapiens_hsa050101.22367881
31Pancreatic cancer_Homo sapiens_hsa052121.19869066
32Bladder cancer_Homo sapiens_hsa052191.05706246
33Non-small cell lung cancer_Homo sapiens_hsa052231.05523785
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05158659
35mRNA surveillance pathway_Homo sapiens_hsa030151.04900131
36One carbon pool by folate_Homo sapiens_hsa006701.03831512
37mTOR signaling pathway_Homo sapiens_hsa041501.03384744
38Sulfur metabolism_Homo sapiens_hsa009201.02365147
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96874974
40Renal cell carcinoma_Homo sapiens_hsa052110.95061929
41Colorectal cancer_Homo sapiens_hsa052100.90967724
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90232669
43Acute myeloid leukemia_Homo sapiens_hsa052210.90124688
44VEGF signaling pathway_Homo sapiens_hsa043700.90091476
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.88486040
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.88240438
47Cardiac muscle contraction_Homo sapiens_hsa042600.87000247
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85827406
49Epstein-Barr virus infection_Homo sapiens_hsa051690.84492255
50Carbon metabolism_Homo sapiens_hsa012000.81637349
51Vibrio cholerae infection_Homo sapiens_hsa051100.81500888
52Insulin signaling pathway_Homo sapiens_hsa049100.81192697
53Glioma_Homo sapiens_hsa052140.81005306
54Apoptosis_Homo sapiens_hsa042100.77749758
55Fatty acid elongation_Homo sapiens_hsa000620.77196287
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76384183
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76258456
58Endocytosis_Homo sapiens_hsa041440.75750652
59Tyrosine metabolism_Homo sapiens_hsa003500.75226918
60Cell cycle_Homo sapiens_hsa041100.73395695
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.71460627
62Vitamin B6 metabolism_Homo sapiens_hsa007500.70744968
63ErbB signaling pathway_Homo sapiens_hsa040120.69735238
64p53 signaling pathway_Homo sapiens_hsa041150.69506996
65HTLV-I infection_Homo sapiens_hsa051660.67894328
66Endometrial cancer_Homo sapiens_hsa052130.66856322
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66623636
68Galactose metabolism_Homo sapiens_hsa000520.64580662
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64557332
70Basal transcription factors_Homo sapiens_hsa030220.60090731
71MicroRNAs in cancer_Homo sapiens_hsa052060.58425029
72Thyroid cancer_Homo sapiens_hsa052160.58058080
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57577985
74Small cell lung cancer_Homo sapiens_hsa052220.55470475
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.55326864
76Lysosome_Homo sapiens_hsa041420.52697908
77Non-homologous end-joining_Homo sapiens_hsa034500.51672357
78HIF-1 signaling pathway_Homo sapiens_hsa040660.51320791
79Melanoma_Homo sapiens_hsa052180.51116163
80Protein export_Homo sapiens_hsa030600.50268569
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49449141
82Melanogenesis_Homo sapiens_hsa049160.49079074
83Circadian rhythm_Homo sapiens_hsa047100.48007165
84Fructose and mannose metabolism_Homo sapiens_hsa000510.47594996
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46423973
86FoxO signaling pathway_Homo sapiens_hsa040680.45768136
87Shigellosis_Homo sapiens_hsa051310.44587612
88Viral carcinogenesis_Homo sapiens_hsa052030.42977074
89Prostate cancer_Homo sapiens_hsa052150.42658134
90Notch signaling pathway_Homo sapiens_hsa043300.41451444
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40730598
92Hepatitis B_Homo sapiens_hsa051610.40267025
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39094943
94Synaptic vesicle cycle_Homo sapiens_hsa047210.38701180
95Herpes simplex infection_Homo sapiens_hsa051680.37052512
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.35245484
97Mismatch repair_Homo sapiens_hsa034300.34434332
98Metabolic pathways_Homo sapiens_hsa011000.34398248
99RNA degradation_Homo sapiens_hsa030180.33652567
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32582828

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