CTAG1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.42396466
2ribosomal small subunit biogenesis (GO:0042274)8.11110162
3formation of translation preinitiation complex (GO:0001731)6.99572905
4viral transcription (GO:0019083)6.66080408
5melanin biosynthetic process (GO:0042438)6.32299789
6translational termination (GO:0006415)6.25972750
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.93386192
8melanin metabolic process (GO:0006582)5.85889432
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.67416901
10translational elongation (GO:0006414)5.61061940
11protein targeting to ER (GO:0045047)5.52328567
12cotranslational protein targeting to membrane (GO:0006613)5.50756092
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.29036063
14protein localization to endoplasmic reticulum (GO:0070972)5.26715030
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.26130177
16translational initiation (GO:0006413)5.23260540
17ribosomal large subunit biogenesis (GO:0042273)5.19197291
18viral life cycle (GO:0019058)5.17420775
19secondary metabolite biosynthetic process (GO:0044550)4.91958667
20ribonucleoprotein complex biogenesis (GO:0022613)4.90065445
21cellular protein complex disassembly (GO:0043624)4.86859267
22regulation of mammary gland epithelial cell proliferation (GO:0033599)4.46781789
23protein complex disassembly (GO:0043241)4.38351329
24macromolecular complex disassembly (GO:0032984)4.19647513
25protein targeting to membrane (GO:0006612)4.13133765
26Golgi transport vesicle coating (GO:0048200)4.05797628
27COPI coating of Golgi vesicle (GO:0048205)4.05797628
28translation (GO:0006412)3.97809130
29mitochondrial fusion (GO:0008053)3.96609875
30T cell apoptotic process (GO:0070231)3.96179397
31protein maturation by protein folding (GO:0022417)3.86053892
32ribosome biogenesis (GO:0042254)3.77622271
33rRNA modification (GO:0000154)3.67298424
34ribosome assembly (GO:0042255)3.61677660
35mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.52806661
36cellular component biogenesis (GO:0044085)3.47546935
37response to gravity (GO:0009629)3.44003746
38lymphocyte apoptotic process (GO:0070227)3.42465753
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.39060942
40regulation of translational fidelity (GO:0006450)3.34923740
41guanosine-containing compound biosynthetic process (GO:1901070)3.27105752
42mRNA catabolic process (GO:0006402)3.23663191
43nucleobase-containing small molecule interconversion (GO:0015949)3.21732078
44termination of RNA polymerase III transcription (GO:0006386)3.16279919
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.16279919
46regulation of gonadotropin secretion (GO:0032276)3.15194102
47GMP metabolic process (GO:0046037)3.12228542
48maturation of SSU-rRNA (GO:0030490)3.11476853
49protein targeting to mitochondrion (GO:0006626)3.10871126
50establishment of protein localization to mitochondrion (GO:0072655)3.08429174
51establishment of protein localization to membrane (GO:0090150)3.07920905
52mesenchyme development (GO:0060485)3.07606955
53regulation of protein heterodimerization activity (GO:0043497)3.06730615
54negative regulation of catenin import into nucleus (GO:0035414)3.03900985
55gonadal mesoderm development (GO:0007506)20.5081186
56protein insertion into membrane (GO:0051205)2.99555635
57negative regulation of necroptotic process (GO:0060546)2.98786704
58RNA catabolic process (GO:0006401)2.96121620
59protein targeting (GO:0006605)2.93414998
60mesoderm development (GO:0007498)2.92448879
61peptidyl-histidine modification (GO:0018202)2.92218745
62modulation by virus of host process (GO:0019054)2.91459362
63endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.90816697
64myeloid cell homeostasis (GO:0002262)2.88286460
65positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.87312832
66rRNA methylation (GO:0031167)2.86084398
67tyrosine metabolic process (GO:0006570)2.85988126
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.84138621
69nuclear envelope reassembly (GO:0031468)2.80927414
70mitotic nuclear envelope reassembly (GO:0007084)2.80927414
71rRNA processing (GO:0006364)2.78234864
72negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.76058343
73GDP-mannose metabolic process (GO:0019673)2.72491881
74pinocytosis (GO:0006907)2.71948804
75positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.70705925
76protein localization to mitochondrion (GO:0070585)2.68217790
77regulation of early endosome to late endosome transport (GO:2000641)2.68160204
78establishment of protein localization to organelle (GO:0072594)2.68006257
79leukocyte apoptotic process (GO:0071887)2.66826793
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.62221343
81barbed-end actin filament capping (GO:0051016)2.61691767
82amyloid precursor protein catabolic process (GO:0042987)2.61150520
83rRNA metabolic process (GO:0016072)2.60046184
84intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.57983914
85regulation of translational initiation (GO:0006446)2.57955154
86endothelial cell chemotaxis (GO:0035767)2.55171782
87negative regulation of cell size (GO:0045792)2.54834105
88peptidyl-proline hydroxylation (GO:0019511)2.54557702
89ribonucleoprotein complex assembly (GO:0022618)2.52931037
90heterochromatin organization (GO:0070828)2.52403845
91negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.51895911
92regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.51457777
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.51403013
94SMAD protein complex assembly (GO:0007183)2.51327616
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50359008
96modulation by symbiont of host cellular process (GO:0044068)2.49881636
97enteric nervous system development (GO:0048484)2.49670736
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49624286
99fusion of sperm to egg plasma membrane (GO:0007342)2.48026139
100pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.46322458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70929100
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.68407545
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44068676
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.31740621
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94823615
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.84094518
7XRN2_22483619_ChIP-Seq_HELA_Human2.64945259
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62989152
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62299018
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45279041
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34104627
12TTF2_22483619_ChIP-Seq_HELA_Human2.32524365
13DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.29538558
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24073280
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17037977
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12086391
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10392501
18DCP1A_22483619_ChIP-Seq_HELA_Human2.09907541
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08907449
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.08312052
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07532995
22GABP_19822575_ChIP-Seq_HepG2_Human1.99249087
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.94942911
24ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90770091
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86919814
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.84689369
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.84131953
28MYC_22102868_ChIP-Seq_BL_Human1.80755078
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79776831
30RACK7_27058665_Chip-Seq_MCF-7_Human1.79523570
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77613128
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77336891
33ZNF263_19887448_ChIP-Seq_K562_Human1.74026123
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73879802
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70294732
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64573516
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63095563
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62008209
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61757765
40TFEB_21752829_ChIP-Seq_HELA_Human1.59743241
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59660094
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58366978
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54199654
44VDR_21846776_ChIP-Seq_THP-1_Human1.53594355
45CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53388185
46KDM5A_27292631_Chip-Seq_BREAST_Human1.51309759
47LXR_22292898_ChIP-Seq_THP-1_Human1.49869552
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.49786981
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47889400
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45752627
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45519008
52SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45298656
53ATF3_27146783_Chip-Seq_COLON_Human1.44112602
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43778913
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38378299
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36841483
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36644202
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35563288
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35477714
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35375460
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34095894
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31075274
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30895883
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29302180
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27536678
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.27000438
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25829551
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25117411
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24114823
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22748822
71VDR_23849224_ChIP-Seq_CD4+_Human1.22475898
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22243265
73CIITA_25753668_ChIP-Seq_RAJI_Human1.20738266
74MAF_26560356_Chip-Seq_TH2_Human1.20668130
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20510147
76FOXP3_21729870_ChIP-Seq_TREG_Human1.19347622
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19020861
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16752627
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16736088
80TP53_22127205_ChIP-Seq_IMR90_Human1.16446239
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15330202
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14987816
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14736413
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14320939
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.13740573
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.10269438
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10024681
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08671771
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.08649356
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07430587
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06994698
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06662599
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06409884
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06039761
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.05797733
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05082564
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03340016
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.02591189
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01122680
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00430695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.05166121
2MP0003136_yellow_coat_color4.59013902
3MP0005408_hypopigmentation3.90837913
4MP0010030_abnormal_orbit_morphology3.81568673
5MP0005451_abnormal_body_composition3.50282675
6MP0009379_abnormal_foot_pigmentation3.35896070
7MP0001661_extended_life_span2.79889351
8MP0002877_abnormal_melanocyte_morpholog2.73215524
9MP0000372_irregular_coat_pigmentation2.65930792
10MP0000358_abnormal_cell_content/2.40217902
11MP0008438_abnormal_cutaneous_collagen2.23093052
12MP0001348_abnormal_lacrimal_gland2.23053219
13MP0004381_abnormal_hair_follicle2.21008521
14MP0005174_abnormal_tail_pigmentation2.19671175
15MP0000015_abnormal_ear_pigmentation2.15234322
16MP0002095_abnormal_skin_pigmentation2.04242663
17MP0002075_abnormal_coat/hair_pigmentati1.96093981
18MP0006035_abnormal_mitochondrial_morpho1.87089036
19MP0008007_abnormal_cellular_replicative1.85428176
20MP0001186_pigmentation_phenotype1.84193841
21MP0004233_abnormal_muscle_weight1.82709246
22MP0005075_abnormal_melanosome_morpholog1.73555174
23MP0004858_abnormal_nervous_system1.60014231
24MP0003693_abnormal_embryo_hatching1.59564206
25MP0000371_diluted_coat_color1.56983780
26MP0000750_abnormal_muscle_regeneration1.56975130
27MP0003077_abnormal_cell_cycle1.55293865
28MP0000733_abnormal_muscle_development1.51373616
29MP0005058_abnormal_lysosome_morphology1.50187671
30MP0008932_abnormal_embryonic_tissue1.47828231
31MP0004957_abnormal_blastocyst_morpholog1.44276130
32MP0000534_abnormal_ureter_morphology1.44034727
33MP0005501_abnormal_skin_physiology1.43084115
34MP0002089_abnormal_postnatal_growth/wei1.40026434
35MP0003111_abnormal_nucleus_morphology1.40016154
36MP0000350_abnormal_cell_proliferation1.38990339
37MP0002938_white_spotting1.38512608
38MP0009697_abnormal_copulation1.32931626
39MP0005197_abnormal_uvea_morphology1.24692982
40MP0009840_abnormal_foam_cell1.24363669
41MP0000759_abnormal_skeletal_muscle1.21335024
42MP0003786_premature_aging1.19477604
43MP0000639_abnormal_adrenal_gland1.18247410
44MP0003186_abnormal_redox_activity1.18014846
45MP0002796_impaired_skin_barrier1.17767125
46MP0008789_abnormal_olfactory_epithelium1.15274718
47MP0008058_abnormal_DNA_repair1.12545899
48MP0002932_abnormal_joint_morphology1.09090967
49MP0009250_abnormal_appendicular_skeleto1.07330186
50MP0000858_altered_metastatic_potential1.05758840
51MP0005257_abnormal_intraocular_pressure1.03239375
52MP0009053_abnormal_anal_canal1.01012961
53MP0002163_abnormal_gland_morphology0.95581746
54MP0000003_abnormal_adipose_tissue0.94049965
55MP0003385_abnormal_body_wall0.93738822
56MP0002060_abnormal_skin_morphology0.93055668
57MP0005384_cellular_phenotype0.92104297
58MP0002080_prenatal_lethality0.91364997
59MP0001324_abnormal_eye_pigmentation0.90728308
60MP0005670_abnormal_white_adipose0.89378261
61MP0000313_abnormal_cell_death0.89172342
62MP0009672_abnormal_birth_weight0.88042055
63MP0001730_embryonic_growth_arrest0.83879951
64MP0002114_abnormal_axial_skeleton0.82640837
65MP0003221_abnormal_cardiomyocyte_apopto0.79038573
66MP0010368_abnormal_lymphatic_system0.79025390
67MP0004043_abnormal_pH_regulation0.77544264
68MP0005666_abnormal_adipose_tissue0.76517088
69MP0009333_abnormal_splenocyte_physiolog0.75460152
70MP0005508_abnormal_skeleton_morphology0.75301144
71MP0005375_adipose_tissue_phenotype0.75104931
72MP0003091_abnormal_cell_migration0.73820764
73MP0005621_abnormal_cell_physiology0.72240338
74MP0000343_altered_response_to0.71102465
75MP0003453_abnormal_keratinocyte_physiol0.70723941
76MP0001697_abnormal_embryo_size0.69782730
77MP0004185_abnormal_adipocyte_glucose0.67644084
78MP0006036_abnormal_mitochondrial_physio0.67367488
79MP0005193_abnormal_anterior_eye0.66906429
80MP0002113_abnormal_skeleton_development0.65698291
81MP0002210_abnormal_sex_determination0.64300723
82MP0004808_abnormal_hematopoietic_stem0.64262118
83MP0000569_abnormal_digit_pigmentation0.64128821
84MP0005330_cardiomyopathy0.62719792
85MP0000678_abnormal_parathyroid_gland0.60785924
86MP0002085_abnormal_embryonic_tissue0.60509848
87MP0003959_abnormal_lean_body0.60216262
88MP0000747_muscle_weakness0.60093522
89MP0002896_abnormal_bone_mineralization0.59827698
90MP0008260_abnormal_autophagy0.58676901
91MP0005623_abnormal_meninges_morphology0.58497670
92MP0002751_abnormal_autonomic_nervous0.58424167
93MP0003123_paternal_imprinting0.56968850
94MP0004510_myositis0.56929829
95MP0001188_hyperpigmentation0.56832940
96MP0002269_muscular_atrophy0.56785943
97MP0010771_integument_phenotype0.56625948
98MP0003634_abnormal_glial_cell0.54750061
99MP0000762_abnormal_tongue_morphology0.54619259
100MP0008770_decreased_survivor_rate0.53129107

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)6.41601555
2White forelock (HP:0002211)5.40256829
3Patchy hypopigmentation of hair (HP:0011365)5.30005257
4Spastic paraparesis (HP:0002313)5.11750275
5Abnormality of cells of the erythroid lineage (HP:0012130)4.83112045
6Spinal cord lesions (HP:0100561)4.75686816
7Syringomyelia (HP:0003396)4.75686816
8Hypoproteinemia (HP:0003075)4.14881061
9Premature graying of hair (HP:0002216)3.93756436
10Abnormal number of erythroid precursors (HP:0012131)3.93153298
11Protrusio acetabuli (HP:0003179)3.88573993
12Paraparesis (HP:0002385)3.63546938
13Upper limb muscle weakness (HP:0003484)3.62562871
14Trismus (HP:0000211)3.60316325
15Abnormality of the distal phalanges of the toes (HP:0010182)3.47985474
16Cerebral hypomyelination (HP:0006808)3.26102858
17Heterochromia iridis (HP:0001100)3.25082522
18Achilles tendon contracture (HP:0001771)3.15997424
19Hypopigmentation of the fundus (HP:0007894)3.15412553
20Distal lower limb muscle weakness (HP:0009053)3.06878095
21Blue irides (HP:0000635)2.96324540
22Abnormal auditory evoked potentials (HP:0006958)2.91628842
23Reticulocytopenia (HP:0001896)2.86009084
24Ocular albinism (HP:0001107)2.74414965
25Multiple lipomas (HP:0001012)2.73405390
26Abnormality of the Achilles tendon (HP:0005109)2.72180216
27Entropion (HP:0000621)2.71552405
28Male infertility (HP:0003251)2.69513192
29Premature rupture of membranes (HP:0001788)2.59157589
30Macrocytic anemia (HP:0001972)2.54150811
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52178410
32Abnormal autonomic nervous system physiology (HP:0012332)2.50421520
33Hand muscle atrophy (HP:0009130)2.50095136
34Delayed cranial suture closure (HP:0000270)2.49609226
35Fatigue (HP:0012378)2.44912993
36Elbow flexion contracture (HP:0002987)2.41749326
37Reduced subcutaneous adipose tissue (HP:0003758)2.40526020
38Rough bone trabeculation (HP:0100670)2.39885047
39Nuclear cataract (HP:0100018)2.38012331
40Distal lower limb amyotrophy (HP:0008944)2.36224994
41Upper limb amyotrophy (HP:0009129)2.35414642
42Distal upper limb amyotrophy (HP:0007149)2.35414642
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.34471267
44Osteolytic defects of the hand bones (HP:0009699)2.34471267
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29648852
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29648852
47Hyperparathyroidism (HP:0000843)2.28340289
48Short nail (HP:0001799)2.27425735
49Deep palmar crease (HP:0006191)2.23445046
50Cutaneous melanoma (HP:0012056)2.22740998
51Iris hypopigmentation (HP:0007730)2.22369010
52Peripheral hypomyelination (HP:0007182)2.21293186
53Albinism (HP:0001022)2.19387568
54Long palpebral fissure (HP:0000637)2.19096378
55Large for gestational age (HP:0001520)2.16995862
56Down-sloping shoulders (HP:0200021)2.16729960
57Generalized hypopigmentation (HP:0007513)2.16188031
58Abnormality of the umbilical cord (HP:0010881)2.11154872
59Rectal prolapse (HP:0002035)2.08744952
60Progressive muscle weakness (HP:0003323)2.07378137
61Microretrognathia (HP:0000308)2.05039905
62CNS hypomyelination (HP:0003429)2.04599813
63Foot dorsiflexor weakness (HP:0009027)2.00263278
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96468589
65Increased connective tissue (HP:0009025)1.96172129
66Myopathic facies (HP:0002058)1.95399187
67Abnormality of subcutaneous fat tissue (HP:0001001)1.93103281
68Broad distal phalanx of finger (HP:0009836)1.89195096
69Round ear (HP:0100830)1.88973631
70Abnormal trabecular bone morphology (HP:0100671)1.88906037
71Spinal cord compression (HP:0002176)1.88109028
72Decreased subcutaneous fat (HP:0001002)1.85869487
73Wormian bones (HP:0002645)1.85831109
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85275763
75Type I transferrin isoform profile (HP:0003642)1.82883308
76Conjunctival hamartoma (HP:0100780)1.81941800
77Ragged-red muscle fibers (HP:0003200)1.81881016
78Glossoptosis (HP:0000162)1.80160506
79Breech presentation (HP:0001623)1.76376608
80Testicular atrophy (HP:0000029)1.75200379
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74940800
82Short clavicles (HP:0000894)1.73951181
83Esophageal neoplasm (HP:0100751)1.72126066
84Neoplasm of head and neck (HP:0012288)1.72126066
85Sparse eyelashes (HP:0000653)1.71438383
86Coxa vara (HP:0002812)1.70092755
87Neoplasm of the peripheral nervous system (HP:0100007)1.68556189
88Blue sclerae (HP:0000592)1.67351521
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67202019
90Melanoma (HP:0002861)1.66375507
91Erythema (HP:0010783)1.66281130
92Abnormality of the foot musculature (HP:0001436)1.65490864
93Distal sensory impairment (HP:0002936)1.64969193
94Difficulty climbing stairs (HP:0003551)1.64869627
95Pallor (HP:0000980)1.64732570
96Abnormality of the fetal cardiovascular system (HP:0010948)1.63481414
97Abnormal umbilical cord blood vessels (HP:0011403)1.63481414
98Single umbilical artery (HP:0001195)1.63481414
99Wide cranial sutures (HP:0010537)1.62603514
100Adducted thumb (HP:0001181)1.62533620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.79365074
2IRAK35.08249984
3EPHA23.20089057
4TRIB33.01222925
5PRPF4B2.93792803
6RPS6KB22.63019213
7ARAF2.60116018
8MOS2.53681603
9PAK42.53203080
10TAOK22.51779444
11LMTK22.45939645
12BRAF2.05313976
13PRKD31.88030965
14ERN11.86764613
15BUB11.82518817
16EEF2K1.78942887
17ILK1.76265271
18IRAK21.75378205
19FLT31.60346658
20PAK61.57687768
21EIF2AK31.53139369
22STK161.48689755
23IRAK41.44939438
24SCYL21.42942079
25ICK1.42108017
26PIM21.41628732
27VRK21.33534350
28NTRK11.29746763
29LRRK21.28935838
30SIK11.24101893
31CDK191.23753964
32NEK11.20865555
33SIK31.20843035
34PAK21.20589237
35PRKD21.11099485
36DDR21.06805156
37DYRK31.05201351
38MAPKAPK31.03265382
39MET1.01530733
40MAP3K91.01385088
41MAP3K110.98000544
42ABL20.96683553
43MARK20.94546482
44AKT20.93686810
45TESK20.93673072
46EPHB10.93669190
47MARK30.89997743
48TESK10.86487803
49CDK80.85559158
50PDPK10.82535300
51LATS20.82427107
52NEK20.82306387
53PAK10.82157777
54PKN20.80064781
55PTK20.78423248
56KSR20.76891166
57PDGFRA0.75561358
58AKT30.70955916
59PASK0.69666099
60CDK30.67988780
61IRAK10.67421790
62CDK70.65229817
63MAP3K80.61992350
64MAP2K30.59084873
65PRKCI0.57695414
66CDK11A0.56583302
67ERBB30.55932700
68MAP3K30.55661155
69ERBB40.53974845
70RPS6KL10.53322687
71RPS6KC10.53322687
72SIK20.53265246
73ZAP700.52065413
74DMPK0.47564268
75MTOR0.47472521
76GSK3A0.46545491
77MAP3K130.45773120
78BMPR20.45641261
79BRSK10.44851594
80CDK150.43513092
81AURKA0.42421635
82ROCK20.39776101
83CDK180.39529924
84RPS6KA60.38819052
85RAF10.38320412
86BCKDK0.38048659
87MAP2K20.37407852
88CDK140.37405481
89MAPKAPK20.37302059
90TGFBR10.37084814
91CHEK20.37045793
92CDK60.36687411
93DAPK10.35494257
94PHKG10.35216893
95PHKG20.35216893
96WEE10.34729748
97MAP3K10.34424606
98DAPK30.33473451
99TBK10.29886683
100LIMK10.29329389

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.36549007
2Sulfur relay system_Homo sapiens_hsa041223.61885022
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76494572
4RNA polymerase_Homo sapiens_hsa030202.76411367
5Pyrimidine metabolism_Homo sapiens_hsa002402.42799777
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23278013
7Proteasome_Homo sapiens_hsa030502.01994755
8SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97692301
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96005711
10Base excision repair_Homo sapiens_hsa034101.90270725
11N-Glycan biosynthesis_Homo sapiens_hsa005101.78690383
12Spliceosome_Homo sapiens_hsa030401.72909176
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68513171
14RNA transport_Homo sapiens_hsa030131.62589701
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55423817
16Nucleotide excision repair_Homo sapiens_hsa034201.54811603
17Prion diseases_Homo sapiens_hsa050201.54727478
18Parkinsons disease_Homo sapiens_hsa050121.48848788
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43419665
20DNA replication_Homo sapiens_hsa030301.41823255
21Oxidative phosphorylation_Homo sapiens_hsa001901.40577260
22Pentose phosphate pathway_Homo sapiens_hsa000301.39139181
23Chronic myeloid leukemia_Homo sapiens_hsa052201.38476197
24Huntingtons disease_Homo sapiens_hsa050161.37771789
25Folate biosynthesis_Homo sapiens_hsa007901.36778045
26Selenocompound metabolism_Homo sapiens_hsa004501.34119496
27Pancreatic cancer_Homo sapiens_hsa052121.32615455
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30889985
29Biosynthesis of amino acids_Homo sapiens_hsa012301.24248464
30Purine metabolism_Homo sapiens_hsa002301.22918217
31mTOR signaling pathway_Homo sapiens_hsa041501.20685556
32Alzheimers disease_Homo sapiens_hsa050101.16429175
33Non-small cell lung cancer_Homo sapiens_hsa052231.14158172
34mRNA surveillance pathway_Homo sapiens_hsa030151.10418165
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09417088
36Bladder cancer_Homo sapiens_hsa052191.09138414
37Colorectal cancer_Homo sapiens_hsa052101.06101361
38VEGF signaling pathway_Homo sapiens_hsa043701.05665692
39Renal cell carcinoma_Homo sapiens_hsa052111.04083906
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00417983
41One carbon pool by folate_Homo sapiens_hsa006700.98495401
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.96615835
43Acute myeloid leukemia_Homo sapiens_hsa052210.96527734
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90519752
45Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90454821
46Glioma_Homo sapiens_hsa052140.89756587
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.88004325
48Sulfur metabolism_Homo sapiens_hsa009200.86940616
49Epstein-Barr virus infection_Homo sapiens_hsa051690.86520056
50Insulin signaling pathway_Homo sapiens_hsa049100.86336702
51ErbB signaling pathway_Homo sapiens_hsa040120.82940897
52Fatty acid elongation_Homo sapiens_hsa000620.81988485
53Apoptosis_Homo sapiens_hsa042100.80785321
54Cardiac muscle contraction_Homo sapiens_hsa042600.80161609
55Carbon metabolism_Homo sapiens_hsa012000.76425555
56Tyrosine metabolism_Homo sapiens_hsa003500.76083900
57Endocytosis_Homo sapiens_hsa041440.76058491
58Endometrial cancer_Homo sapiens_hsa052130.74890522
59Cell cycle_Homo sapiens_hsa041100.74784860
60Vibrio cholerae infection_Homo sapiens_hsa051100.72582178
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72509212
62p53 signaling pathway_Homo sapiens_hsa041150.72446987
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71158633
64Galactose metabolism_Homo sapiens_hsa000520.69440872
65HTLV-I infection_Homo sapiens_hsa051660.69406065
66Thyroid cancer_Homo sapiens_hsa052160.68782256
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67594170
68Small cell lung cancer_Homo sapiens_hsa052220.64175997
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.62920164
70MicroRNAs in cancer_Homo sapiens_hsa052060.62685649
71Basal transcription factors_Homo sapiens_hsa030220.60818752
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60065587
73HIF-1 signaling pathway_Homo sapiens_hsa040660.59357931
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56789187
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54028348
76Melanogenesis_Homo sapiens_hsa049160.53940402
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.53775368
78Vitamin B6 metabolism_Homo sapiens_hsa007500.53646827
79Fructose and mannose metabolism_Homo sapiens_hsa000510.52713013
80Melanoma_Homo sapiens_hsa052180.52574673
81Notch signaling pathway_Homo sapiens_hsa043300.51005235
82Prostate cancer_Homo sapiens_hsa052150.50545078
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48668177
84FoxO signaling pathway_Homo sapiens_hsa040680.47553071
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46945841
86Lysosome_Homo sapiens_hsa041420.46698644
87Hepatitis B_Homo sapiens_hsa051610.46614162
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43663210
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.43243593
90Shigellosis_Homo sapiens_hsa051310.40444550
91Protein export_Homo sapiens_hsa030600.40289447
92Viral carcinogenesis_Homo sapiens_hsa052030.40156706
93Synaptic vesicle cycle_Homo sapiens_hsa047210.36646584
94Mismatch repair_Homo sapiens_hsa034300.36572129
95Circadian rhythm_Homo sapiens_hsa047100.36504021
96AMPK signaling pathway_Homo sapiens_hsa041520.36336366
97Proteoglycans in cancer_Homo sapiens_hsa052050.35752960
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34741971
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33665693
100Other glycan degradation_Homo sapiens_hsa005110.32483406

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