CTAG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.95777554
2epithelial cilium movement (GO:0003351)9.79729113
3axonemal dynein complex assembly (GO:0070286)9.71875525
4spermatid development (GO:0007286)9.60130119
5cilium or flagellum-dependent cell motility (GO:0001539)9.04738677
6motile cilium assembly (GO:0044458)8.85764748
7regulation of cilium movement (GO:0003352)8.33840938
8cilium movement (GO:0003341)8.02635553
9single fertilization (GO:0007338)7.61938625
10synaptonemal complex assembly (GO:0007130)7.61428025
11male meiosis (GO:0007140)7.57242092
12synaptonemal complex organization (GO:0070193)7.56208239
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45816473
14sperm capacitation (GO:0048240)7.38849934
15piRNA metabolic process (GO:0034587)7.11677415
16spermatogenesis (GO:0007283)6.61686613
17male gamete generation (GO:0048232)6.59415428
18negative regulation of inclusion body assembly (GO:0090084)6.59050117
19microtubule depolymerization (GO:0007019)6.53643314
20fertilization (GO:0009566)6.39815868
21organic cation transport (GO:0015695)6.08028345
22gamete generation (GO:0007276)6.06465167
23spermatid nucleus differentiation (GO:0007289)5.79299659
24nuclear pore complex assembly (GO:0051292)5.68656228
25ribosomal small subunit biogenesis (GO:0042274)5.65770172
26regulation of inclusion body assembly (GO:0090083)5.50575595
27calcium ion-dependent exocytosis (GO:0017156)5.47948063
28positive regulation of odontogenesis (GO:0042482)5.40083852
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.38832255
30germ cell development (GO:0007281)5.36119210
31homocysteine metabolic process (GO:0050667)5.32355914
32chromosome organization involved in meiosis (GO:0070192)5.24236147
33ventricular system development (GO:0021591)5.22755274
34regulation of translational fidelity (GO:0006450)5.21567550
35cell recognition (GO:0008037)5.16565023
36midgut development (GO:0007494)5.10986422
37microtubule severing (GO:0051013)5.01716539
38glycerol ether metabolic process (GO:0006662)4.90950582
39regulation of microtubule-based movement (GO:0060632)4.88265673
40chromosome condensation (GO:0030261)4.86636732
41male meiosis I (GO:0007141)4.79662253
42multicellular organismal reproductive process (GO:0048609)4.76171456
43nuclear pore organization (GO:0006999)4.76002671
44DNA methylation involved in gamete generation (GO:0043046)4.74165926
45maturation of SSU-rRNA (GO:0030490)4.60934713
46DNA packaging (GO:0006323)4.56167147
47ether metabolic process (GO:0018904)4.53859195
48meiotic nuclear division (GO:0007126)4.47296917
49sexual reproduction (GO:0019953)4.35125925
50seminiferous tubule development (GO:0072520)4.34931038
51formation of translation preinitiation complex (GO:0001731)4.34061934
52single strand break repair (GO:0000012)4.32990763
53pore complex assembly (GO:0046931)4.23521594
54folic acid metabolic process (GO:0046655)4.20624403
55viral transcription (GO:0019083)4.19099430
56cornea development in camera-type eye (GO:0061303)4.17133299
57tyrosine metabolic process (GO:0006570)4.16725211
58Golgi transport vesicle coating (GO:0048200)4.06421999
59COPI coating of Golgi vesicle (GO:0048205)4.06421999
60translational termination (GO:0006415)4.04271939
61urea cycle (GO:0000050)4.03924370
62monoubiquitinated protein deubiquitination (GO:0035520)4.03356673
63melanin biosynthetic process (GO:0042438)4.00768884
64ribonucleoprotein complex biogenesis (GO:0022613)3.99659262
65chaperone-mediated protein complex assembly (GO:0051131)3.91722317
66meiosis I (GO:0007127)3.89081907
67mitotic chromosome condensation (GO:0007076)3.86669179
68multicellular organismal development (GO:0007275)3.83233267
69protein K11-linked deubiquitination (GO:0035871)3.83225046
70hepatocyte differentiation (GO:0070365)3.80372479
71left/right pattern formation (GO:0060972)3.76219339
72melanin metabolic process (GO:0006582)3.76083819
73protein polyglutamylation (GO:0018095)3.76033714
74ribosomal large subunit biogenesis (GO:0042273)3.74767199
75mitotic nuclear envelope disassembly (GO:0007077)3.66975894
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65700053
77genitalia morphogenesis (GO:0035112)3.61863077
78ribosome biogenesis (GO:0042254)3.61722084
79nucleobase-containing small molecule interconversion (GO:0015949)3.60176461
80urea metabolic process (GO:0019627)3.56801628
81DNA strand elongation involved in DNA replication (GO:0006271)3.56147075
82negative regulation of complement activation (GO:0045916)3.54869967
83cotranslational protein targeting to membrane (GO:0006613)3.53657693
84translational elongation (GO:0006414)3.53531400
85protein targeting to ER (GO:0045047)3.51445201
86DNA replication checkpoint (GO:0000076)3.48123345
87DNA replication initiation (GO:0006270)3.48055916
88sequestering of actin monomers (GO:0042989)3.46002019
89DNA strand elongation (GO:0022616)3.45943643
90mitotic sister chromatid segregation (GO:0000070)3.45850360
91nuclear envelope disassembly (GO:0051081)3.45810693
92membrane disassembly (GO:0030397)3.45810693
93microtubule polymerization or depolymerization (GO:0031109)3.44589141
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41977664
95establishment of apical/basal cell polarity (GO:0035089)3.41530632
96translational initiation (GO:0006413)3.38416671
97telomere maintenance via semi-conservative replication (GO:0032201)3.37767099
98establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37487689
99protein localization to endoplasmic reticulum (GO:0070972)3.34778196
100mesenchyme development (GO:0060485)3.34048010
101DNA unwinding involved in DNA replication (GO:0006268)3.31723014
102oxidative phosphorylation (GO:0006119)3.30694590
103regulation of spindle checkpoint (GO:0090231)3.29230847
104citrulline biosynthetic process (GO:0019240)3.27953471
105nitrogen cycle metabolic process (GO:0071941)3.26992922
106cellular protein complex disassembly (GO:0043624)3.24846103
107tRNA aminoacylation for protein translation (GO:0006418)3.24320111
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23078722
109L-alpha-amino acid transmembrane transport (GO:1902475)3.20375579
110nephron tubule formation (GO:0072079)3.18477804
111GTP biosynthetic process (GO:0006183)3.17653953
112transcription from mitochondrial promoter (GO:0006390)3.13374528
113viral life cycle (GO:0019058)3.11582566
114tRNA aminoacylation (GO:0043039)3.11363569
115amino acid activation (GO:0043038)3.11363569
116meiotic cell cycle (GO:0051321)3.10956408
117synapsis (GO:0007129)3.10808356
118nucleoside diphosphate phosphorylation (GO:0006165)3.09415818
119glycolytic process (GO:0006096)3.09145240
120negative regulation of protein activation cascade (GO:2000258)3.06075417
121positive regulation of viral genome replication (GO:0045070)3.05975653
122sister chromatid segregation (GO:0000819)3.02485476
123meiotic cell cycle process (GO:1903046)3.01170587
124tRNA methylation (GO:0030488)2.98705713
125citrulline metabolic process (GO:0000052)2.98477716
126secondary metabolite biosynthetic process (GO:0044550)2.98416965
127regulation of translational elongation (GO:0006448)2.97627432
128protein refolding (GO:0042026)2.97534691
129polyol catabolic process (GO:0046174)2.96796019
130nucleus organization (GO:0006997)2.96402015
131rRNA processing (GO:0006364)2.94591783
132protein complex disassembly (GO:0043241)2.92471731
133protein localization to cilium (GO:0061512)2.92222002
134amino-acid betaine transport (GO:0015838)2.91204684
135carnitine transport (GO:0015879)2.91204684
136ribosomal small subunit assembly (GO:0000028)2.87532788
137mitotic sister chromatid cohesion (GO:0007064)2.86179200
138alditol metabolic process (GO:0019400)2.84830918
139regulation of RNA export from nucleus (GO:0046831)2.84503697
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84472985
141mitochondrial RNA metabolic process (GO:0000959)2.83727781
142diaphragm development (GO:0060539)2.83594832
143positive regulation of macrophage activation (GO:0043032)2.83246257
144UTP biosynthetic process (GO:0006228)2.82986424
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82150687
146L-phenylalanine metabolic process (GO:0006558)2.82150687
147mitochondrial DNA metabolic process (GO:0032042)2.81714324
148cellular component biogenesis (GO:0044085)2.81467252
149macromolecular complex disassembly (GO:0032984)2.80884635
150telomere maintenance via recombination (GO:0000722)2.80461647
151myeloid cell homeostasis (GO:0002262)2.79351815
152lactate metabolic process (GO:0006089)2.79114302
153protein maturation by protein folding (GO:0022417)2.78797457
154rRNA metabolic process (GO:0016072)2.78347278
155cilium organization (GO:0044782)2.78294462
156carnitine transmembrane transport (GO:1902603)2.77592871
157DNA synthesis involved in DNA repair (GO:0000731)2.77391505
158mesoderm development (GO:0007498)2.76789728
159non-recombinational repair (GO:0000726)2.74407431
160double-strand break repair via nonhomologous end joining (GO:0006303)2.74407431
161translation (GO:0006412)2.74045500
162cellular component assembly involved in morphogenesis (GO:0010927)2.72352952
163ribosome assembly (GO:0042255)2.72218911
164rRNA modification (GO:0000154)2.72042091
165microtubule-based movement (GO:0007018)2.71955872
166nuclear envelope organization (GO:0006998)2.71233234
167metanephric mesenchyme development (GO:0072075)2.71126254
168interferon-gamma secretion (GO:0072643)2.70151852
169response to dexamethasone (GO:0071548)2.68238239
170establishment of monopolar cell polarity (GO:0061162)2.67609477
171establishment or maintenance of monopolar cell polarity (GO:0061339)2.67609477
172proline biosynthetic process (GO:0006561)2.67608794
173spliceosomal tri-snRNP complex assembly (GO:0000244)2.67279133
174cilium assembly (GO:0042384)2.66879646
175mitotic metaphase plate congression (GO:0007080)2.66789221
176folic acid-containing compound metabolic process (GO:0006760)2.65527642
177intraciliary transport (GO:0042073)2.64785282
178cilium morphogenesis (GO:0060271)2.62913713
179chromatin silencing (GO:0006342)2.58904601
180UTP metabolic process (GO:0046051)2.56415874
181gene silencing by RNA (GO:0031047)2.51325409
182negative regulation of organelle assembly (GO:1902116)2.50810742
183axoneme assembly (GO:0035082)2.46556453
184centriole assembly (GO:0098534)2.45667941
185polyamine biosynthetic process (GO:0006596)2.42748195
186histone exchange (GO:0043486)2.41881766
187glycerol metabolic process (GO:0006071)2.39255816
188cell redox homeostasis (GO:0045454)2.37879880
189gonadal mesoderm development (GO:0007506)17.9957052
190sperm motility (GO:0030317)14.0147046
191fusion of sperm to egg plasma membrane (GO:0007342)13.7739507
192cell wall macromolecule metabolic process (GO:0044036)13.6874754
193cell wall macromolecule catabolic process (GO:0016998)13.6874754
194acrosome assembly (GO:0001675)12.8165867
195sperm-egg recognition (GO:0035036)11.8914818
196acrosome reaction (GO:0007340)11.6562363
197multicellular organism reproduction (GO:0032504)11.5596373
198binding of sperm to zona pellucida (GO:0007339)10.7580990
199cell-cell recognition (GO:0009988)10.6510619
200plasma membrane fusion (GO:0045026)10.4870464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.09274305
2E2F7_22180533_ChIP-Seq_HELA_Human7.70441893
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.87949128
4ZNF263_19887448_ChIP-Seq_K562_Human4.59886088
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.05749928
6EZH2_22144423_ChIP-Seq_EOC_Human3.80732781
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50037159
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35281405
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27283054
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.13772274
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08763900
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83054751
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81432389
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74739514
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67699415
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64240816
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62424242
18XRN2_22483619_ChIP-Seq_HELA_Human2.56144926
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49386776
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.42490350
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.41478273
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38368134
23VDR_22108803_ChIP-Seq_LS180_Human2.34983489
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31988477
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31134374
26DCP1A_22483619_ChIP-Seq_HELA_Human2.28546429
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26939288
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23063599
29TFEB_21752829_ChIP-Seq_HELA_Human2.13315359
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11881203
31PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11839084
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11151404
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11075632
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.08257714
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.02681454
36GATA1_26923725_Chip-Seq_HPCs_Mouse2.02118816
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01379363
38ZNF274_21170338_ChIP-Seq_K562_Hela1.99460578
39TTF2_22483619_ChIP-Seq_HELA_Human1.97079695
40MYC_22102868_ChIP-Seq_BL_Human1.96120334
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94281265
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.93902404
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91891321
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.89979590
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78269627
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78024069
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77766952
48* CBX2_27304074_Chip-Seq_ESCs_Mouse1.77348087
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77189306
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75934161
51STAT1_17558387_ChIP-Seq_HELA_Human1.74963365
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.71965940
53KDM5A_27292631_Chip-Seq_BREAST_Human1.70874890
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70679046
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68265754
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.66582547
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66423209
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64360766
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62967079
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62676624
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61485020
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60717192
63FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60510434
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58162252
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57025149
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.56101347
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.55076229
68SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54918807
69* KDM2B_26808549_Chip-Seq_REH_Human1.53605400
70GABP_19822575_ChIP-Seq_HepG2_Human1.52050282
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.50700908
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48075431
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.47487238
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47322372
75AR_21909140_ChIP-Seq_LNCAP_Human1.43706951
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41490563
77CBP_20019798_ChIP-Seq_JUKART_Human1.39326716
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39326716
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38925599
80FOXP3_21729870_ChIP-Seq_TREG_Human1.38793992
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.38035547
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37280451
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36138612
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.34564695
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34548405
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.34043579
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33430337
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33125770
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32416929
90* GATA3_21867929_ChIP-Seq_TH1_Mouse1.31881846
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31866444
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31618421
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31504021
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30978599
95RNF2_27304074_Chip-Seq_NSC_Mouse1.30779077
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28233707
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.28003131
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27868225
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27415311
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27306246
101P53_21459846_ChIP-Seq_SAOS-2_Human1.26694270
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25016804
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24829026
104FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24002000
105REST_21632747_ChIP-Seq_MESCs_Mouse1.23188383
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22557275
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.22439148
108RACK7_27058665_Chip-Seq_MCF-7_Human1.22081722
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21786580
110GF1_26923725_Chip-Seq_HPCs_Mouse1.21698615
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21075707
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20990116
113NCOR1_26117541_ChIP-Seq_K562_Human1.20986641
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.20711211
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20470245
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20360166
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20191635
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20191635
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.19671056
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18869628
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17060481
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16975354
123RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16210272
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15703195
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15107334
126P53_22387025_ChIP-Seq_ESCs_Mouse1.14738052
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14105466
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.13766829
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13586563
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12604368
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12348842
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12071449
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11758785
134ELK1_19687146_ChIP-ChIP_HELA_Human1.11361701
135TAF15_26573619_Chip-Seq_HEK293_Human1.11319199
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11282474
137SPI1_26923725_Chip-Seq_HPCs_Mouse1.10908221
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10430808
139P300_18555785_Chip-Seq_ESCs_Mouse1.10202570
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10167041
141ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09917497
142ELK3_25401928_ChIP-Seq_HUVEC_Human1.08633338
143PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08554339
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07964938
145KLF4_18555785_Chip-Seq_ESCs_Mouse1.06784758
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06528555
147VDR_21846776_ChIP-Seq_THP-1_Human1.05920428
148RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05738525
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05680354
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05613656
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05153160
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04767601
153CIITA_25753668_ChIP-Seq_RAJI_Human1.04504895
154EZH2_27294783_Chip-Seq_NPCs_Mouse1.04472503
155ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04127991
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03939545
157ESET_19884257_ChIP-Seq_ESCs_Mouse1.03381298
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02936014
159VDR_23849224_ChIP-Seq_CD4+_Human1.02833053
160ERG_20517297_ChIP-Seq_VCAP_Human1.02539780
161SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02516383
162OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02418446
163LXR_22292898_ChIP-Seq_THP-1_Human1.02330822
164CHD1_26751641_Chip-Seq_LNCaP_Human1.01984313
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01714666
166FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00789407
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00745913
168TET1_21451524_ChIP-Seq_MESCs_Mouse0.99207075
169KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98718148
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97330536
171STAT3_18555785_Chip-Seq_ESCs_Mouse0.97283480
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97099138
173TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97026460
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96601144
175ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96516239
176SOX9_26525672_Chip-Seq_HEART_Mouse0.96412954
177SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96002822
178NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95989710
179SOX2_18555785_Chip-Seq_ESCs_Mouse0.95910662
180FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95803385
181RARA_24833708_ChIP-Seq_LIVER_Mouse0.95633610
182LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95596826
183RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95328876
184* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94975150
185GF1B_26923725_Chip-Seq_HPCs_Mouse0.94958239
186NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94120447
187KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93609510
188CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92948169
189ATF3_27146783_Chip-Seq_COLON_Human0.92297137
190GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92275389
191NFYB_21822215_ChIP-Seq_K562_Human0.91971998
192CTCF_18555785_Chip-Seq_ESCs_Mouse0.91714175
193TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91423801
194RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91352205
195GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91322339
196YY1_22570637_ChIP-Seq_MALME-3M_Human0.91103956
197PU1_27457419_Chip-Seq_LIVER_Mouse0.90557994
198MYC_27129775_Chip-Seq_CORNEA_Mouse0.90441482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.17380312
2MP0001929_abnormal_gametogenesis5.67042444
3MP0005171_absent_coat_pigmentation4.74291442
4MP0008877_abnormal_DNA_methylation4.55075943
5MP0010030_abnormal_orbit_morphology3.79770852
6MP0002210_abnormal_sex_determination3.55412774
7MP0002161_abnormal_fertility/fecundity3.35565451
8MP0002877_abnormal_melanocyte_morpholog3.24344408
9MP0004957_abnormal_blastocyst_morpholog3.04899056
10MP0001145_abnormal_male_reproductive3.02322925
11MP0005451_abnormal_body_composition2.96379715
12MP0003136_yellow_coat_color2.84900422
13MP0000653_abnormal_sex_gland2.62846643
14MP0001348_abnormal_lacrimal_gland2.53578254
15MP0005408_hypopigmentation2.53453289
16MP0005670_abnormal_white_adipose2.50492445
17MP0008438_abnormal_cutaneous_collagen2.37520452
18MP0002653_abnormal_ependyma_morphology2.33350556
19MP0003693_abnormal_embryo_hatching2.27930365
20MP0002396_abnormal_hematopoietic_system2.20202492
21MP0000372_irregular_coat_pigmentation2.09234164
22MP0000015_abnormal_ear_pigmentation2.05856352
23MP0000013_abnormal_adipose_tissue2.05570455
24MP0008932_abnormal_embryonic_tissue2.01567412
25MP0005410_abnormal_fertilization16.2688639
26MP0000003_abnormal_adipose_tissue1.95953325
27MP0005058_abnormal_lysosome_morphology1.89750038
28MP0005623_abnormal_meninges_morphology1.81947109
29MP0000733_abnormal_muscle_development1.70119453
30MP0005174_abnormal_tail_pigmentation1.67512071
31MP0001661_extended_life_span1.59066038
32MP0009333_abnormal_splenocyte_physiolog1.56624952
33MP0000350_abnormal_cell_proliferation1.52692846
34MP0010234_abnormal_vibrissa_follicle1.45047678
35MP0008058_abnormal_DNA_repair1.38166763
36MP0002095_abnormal_skin_pigmentation1.34282340
37MP0002160_abnormal_reproductive_system1.33950979
38MP0002075_abnormal_coat/hair_pigmentati1.33143702
39MP0001186_pigmentation_phenotype1.32928893
40MP0003186_abnormal_redox_activity1.29551602
41MP0002282_abnormal_trachea_morphology1.27170450
42MP0008995_early_reproductive_senescence1.24907261
43MP0001346_abnormal_lacrimal_gland1.24666265
44MP0002080_prenatal_lethality1.24083854
45MP0001672_abnormal_embryogenesis/_devel1.24022618
46MP0005380_embryogenesis_phenotype1.24022618
47MP0003646_muscle_fatigue1.21381053
48MP0006035_abnormal_mitochondrial_morpho1.21129655
49MP0003984_embryonic_growth_retardation1.19719073
50MP0000371_diluted_coat_color1.19006176
51MP0001765_abnormal_ion_homeostasis1.15816177
52MP0000759_abnormal_skeletal_muscle1.14833892
53MP0002088_abnormal_embryonic_growth/wei1.13943622
54MP0001697_abnormal_embryo_size1.11749958
55MP0008260_abnormal_autophagy1.11338349
56MP0004233_abnormal_muscle_weight1.10221432
57MP0009046_muscle_twitch1.08937741
58MP0004147_increased_porphyrin_level1.06657526
59MP0002009_preneoplasia1.06393678
60MP0005197_abnormal_uvea_morphology1.05646607
61MP0005647_abnormal_sex_gland1.04114120
62MP0004381_abnormal_hair_follicle1.01691772
63MP0005501_abnormal_skin_physiology1.00512913
64MP0005503_abnormal_tendon_morphology1.00436778
65MP0001984_abnormal_olfaction0.99137916
66MP0005076_abnormal_cell_differentiation0.96563192
67MP0002697_abnormal_eye_size0.96082318
68MP0003705_abnormal_hypodermis_morpholog0.95874135
69MP0000490_abnormal_crypts_of0.93806186
70MP0003718_maternal_effect0.92333352
71MP0002938_white_spotting0.88141453
72MP0009697_abnormal_copulation0.88034225
73MP0009379_abnormal_foot_pigmentation0.87475964
74MP0005083_abnormal_biliary_tract0.87286532
75MP0002086_abnormal_extraembryonic_tissu0.84891522
76MP0008789_abnormal_olfactory_epithelium0.84856563
77MP0009672_abnormal_birth_weight0.82303767
78MP0005330_cardiomyopathy0.81580126
79MP0003566_abnormal_cell_adhesion0.81339283
80MP0002111_abnormal_tail_morphology0.80321954
81MP0005257_abnormal_intraocular_pressure0.79968440
82MP0005384_cellular_phenotype0.79961839
83MP0002932_abnormal_joint_morphology0.78774771
84MP0005621_abnormal_cell_physiology0.78673031
85MP0002060_abnormal_skin_morphology0.77508673
86MP0000750_abnormal_muscle_regeneration0.76363479
87MP0006138_congestive_heart_failure0.75570740
88MP0002085_abnormal_embryonic_tissue0.75534589
89MP0003453_abnormal_keratinocyte_physiol0.75196601
90MP0010352_gastrointestinal_tract_polyps0.74145168
91MP0001188_hyperpigmentation0.73421450
92MP0010094_abnormal_chromosome_stability0.72793975
93MP0000579_abnormal_nail_morphology0.72694411
94MP0001986_abnormal_taste_sensitivity0.72529379
95MP0003959_abnormal_lean_body0.72231784
96MP0004087_abnormal_muscle_fiber0.71704642
97MP0005423_abnormal_somatic_nervous0.71178564
98MP0005389_reproductive_system_phenotype0.71028172
99MP0005375_adipose_tissue_phenotype0.71023869
100MP0002234_abnormal_pharynx_morphology0.70392402
101MP0003011_delayed_dark_adaptation0.69891203
102MP0002019_abnormal_tumor_incidence0.69045980
103MP0005075_abnormal_melanosome_morpholog0.66282110
104MP0000747_muscle_weakness0.66279349
105MP0008057_abnormal_DNA_replication0.66126833
106MP0008775_abnormal_heart_ventricle0.65398166
107MP0005636_abnormal_mineral_homeostasis0.62345965
108MP0003878_abnormal_ear_physiology0.60289614
109MP0005377_hearing/vestibular/ear_phenot0.60289614
110MP0004036_abnormal_muscle_relaxation0.60270797
111MP0003786_premature_aging0.58653919
112MP0003115_abnormal_respiratory_system0.53089389
113MP0003699_abnormal_female_reproductive0.52823673
114MP0001324_abnormal_eye_pigmentation0.51516170
115MP0002928_abnormal_bile_duct0.48757896
116MP0005253_abnormal_eye_physiology0.48015278
117MP0001764_abnormal_homeostasis0.47835638
118MP0005551_abnormal_eye_electrophysiolog0.43697084
119MP0005666_abnormal_adipose_tissue0.43016800
120MP0003111_abnormal_nucleus_morphology0.40864420
121MP0001293_anophthalmia0.40306904
122MP0002736_abnormal_nociception_after0.39686534
123MP0001119_abnormal_female_reproductive0.38814728
124MP0002102_abnormal_ear_morphology0.37819642
125MP0001545_abnormal_hematopoietic_system0.37286022
126MP0005397_hematopoietic_system_phenotyp0.37286022
127MP0004019_abnormal_vitamin_homeostasis0.36246032
128MP0000358_abnormal_cell_content/0.36104720
129MP0008007_abnormal_cellular_replicative0.35831039
130MP0006036_abnormal_mitochondrial_physio0.35451991
131MP0003950_abnormal_plasma_membrane0.35442003
132MP0003329_amyloid_beta_deposits0.34194864
133MP0004133_heterotaxia0.33789295
134MP0005391_vision/eye_phenotype0.33696636
135MP0000569_abnormal_digit_pigmentation0.33590083
136MP0002269_muscular_atrophy0.33512507
137MP0003633_abnormal_nervous_system0.31387184
138MP0010307_abnormal_tumor_latency0.30339613
139MP0001730_embryonic_growth_arrest0.29276349
140MP0009115_abnormal_fat_cell0.28607138
141MP0000534_abnormal_ureter_morphology0.27935019
142MP0009278_abnormal_bone_marrow0.27626000
143MP0004084_abnormal_cardiac_muscle0.27223041
144MP0006072_abnormal_retinal_apoptosis0.25628655
145MP0002971_abnormal_brown_adipose0.24902005
146MP0004811_abnormal_neuron_physiology0.24529844
147MP0003861_abnormal_nervous_system0.24416952
148MP0002169_no_abnormal_phenotype0.23408150
149MP0002873_normal_phenotype0.23185700
150MP0003631_nervous_system_phenotype0.22837873
151MP0004742_abnormal_vestibular_system0.22832489
152MP0002139_abnormal_hepatobiliary_system0.22694481
153MP0003879_abnormal_hair_cell0.22378241
154MP0001968_abnormal_touch/_nociception0.20519277
155MP0002152_abnormal_brain_morphology0.19693979
156MP0001849_ear_inflammation0.19397599
157MP0000313_abnormal_cell_death0.19287977
158MP0004145_abnormal_muscle_electrophysio0.18404569
159MP0004808_abnormal_hematopoietic_stem0.17586148
160MP0003787_abnormal_imprinting0.17485932
161MP0003077_abnormal_cell_cycle0.17097051
162MP0000462_abnormal_digestive_system0.15722510
163MP0003942_abnormal_urinary_system0.15515726
164MP0001727_abnormal_embryo_implantation0.15346368
165MP0002229_neurodegeneration0.15257501
166MP0000001_mammalian_phenotype0.14432043
167MP0003948_abnormal_gas_homeostasis0.14382948
168MP0005195_abnormal_posterior_eye0.14335850
169MP0002092_abnormal_eye_morphology0.14090297
170MP0004043_abnormal_pH_regulation0.13997950
171MP0002084_abnormal_developmental_patter0.13281369
172MP0002132_abnormal_respiratory_system0.12446065
173MP0008875_abnormal_xenobiotic_pharmacok0.12349513
174MP0000604_amyloidosis0.12218922
175MP0004270_analgesia0.11738702
176MP0002295_abnormal_pulmonary_circulatio0.11050798
177MP0009250_abnormal_appendicular_skeleto0.11021432
178MP0005319_abnormal_enzyme/_coenzyme0.10474968

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.71699011
2Abnormal respiratory motile cilium morphology (HP:0005938)9.30010123
3Abnormal respiratory epithelium morphology (HP:0012253)9.30010123
4Abnormal ciliary motility (HP:0012262)8.02161945
5Chronic bronchitis (HP:0004469)7.51210725
6Rhinitis (HP:0012384)7.46140552
7Calcaneovalgus deformity (HP:0001848)6.60714404
8Infertility (HP:0000789)6.60507045
9Nasal polyposis (HP:0100582)6.23712140
10Deformed tarsal bones (HP:0008119)5.79261507
11Abnormality of the nasal mucosa (HP:0000433)5.11748340
12Male infertility (HP:0003251)4.80526428
13Bronchitis (HP:0012387)4.58792801
14Bronchiectasis (HP:0002110)4.36817197
15Abnormality of the calcaneus (HP:0008364)4.18166260
16Abnormal spermatogenesis (HP:0008669)4.02656125
17Reticulocytopenia (HP:0001896)3.99919578
18Nephronophthisis (HP:0000090)3.99591702
19Progressive muscle weakness (HP:0003323)3.76341297
20Recurrent sinusitis (HP:0011108)3.76005863
21Elbow flexion contracture (HP:0002987)3.62109859
22White forelock (HP:0002211)3.49089851
23Vertebral compression fractures (HP:0002953)3.46511983
24Cerebellar dysplasia (HP:0007033)3.46332530
25Patchy hypopigmentation of hair (HP:0011365)3.35268737
26Microvesicular hepatic steatosis (HP:0001414)3.35175333
27Recurrent otitis media (HP:0000403)3.30365277
28Ragged-red muscle fibers (HP:0003200)3.29684626
29Submucous cleft hard palate (HP:0000176)3.18320922
30Hyperalaninemia (HP:0003348)3.15820074
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15820074
32Abnormality of alanine metabolism (HP:0010916)3.15820074
33Cerebral edema (HP:0002181)3.15312611
34Sparse lateral eyebrow (HP:0005338)3.04675190
35Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02404923
36Abnormality of the renal medulla (HP:0100957)3.00108010
37Premature rupture of membranes (HP:0001788)2.96970252
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95964715
39Cutaneous melanoma (HP:0012056)2.92526340
40Abnormality of midbrain morphology (HP:0002418)2.76941867
41Molar tooth sign on MRI (HP:0002419)2.76941867
42Birth length less than 3rd percentile (HP:0003561)2.71316269
43Abnormality of cells of the erythroid lineage (HP:0012130)2.69760240
44Tubulointerstitial nephritis (HP:0001970)2.69078397
45Azoospermia (HP:0000027)2.66388511
46Spinal cord lesions (HP:0100561)2.66228200
47Syringomyelia (HP:0003396)2.66228200
48Chromsome breakage (HP:0040012)2.64423446
49Recurrent bronchitis (HP:0002837)2.63847519
50Overlapping toe (HP:0001845)2.63472445
51Abnormality of glycolysis (HP:0004366)2.61772203
52Spastic paraparesis (HP:0002313)2.61760449
53Macrocytic anemia (HP:0001972)2.61198362
54Pallor (HP:0000980)2.61021427
55Tubular atrophy (HP:0000092)2.53552193
56Medial flaring of the eyebrow (HP:0010747)2.53003990
57Abnormality of the tricuspid valve (HP:0001702)2.48097549
58Abnormality of reticulocytes (HP:0004312)2.47931575
59Increased serum pyruvate (HP:0003542)2.45349592
60Premature graying of hair (HP:0002216)2.43390702
61Lip pit (HP:0100267)2.39460199
62Adducted thumb (HP:0001181)2.38665591
63Abnormal mitochondria in muscle tissue (HP:0008316)2.38652905
64Tubulointerstitial abnormality (HP:0001969)2.34725733
65Abnormal number of incisors (HP:0011064)2.34460628
66Achilles tendon contracture (HP:0001771)2.34264558
67Hypokinesia (HP:0002375)2.33231890
68Breast hypoplasia (HP:0003187)2.29402917
69Abnormality of the distal phalanges of the toes (HP:0010182)2.28381220
70Dysmetric saccades (HP:0000641)2.28203205
71Abnormal number of erythroid precursors (HP:0012131)2.27061699
72Impulsivity (HP:0100710)2.26394938
73Abnormality of pyrimidine metabolism (HP:0004353)2.21831903
74Entropion (HP:0000621)2.21201128
75Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16228845
76Gonadotropin excess (HP:0000837)2.09872252
77Biconcave vertebral bodies (HP:0004586)2.08997931
78Renal duplication (HP:0000075)2.02370140
79Blue irides (HP:0000635)2.00489208
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.6579814
81Absent/shortened dynein arms (HP:0200106)13.6579814
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5356908
83Dyschromatopsia (HP:0007641)1.98901589
84Abnormal auditory evoked potentials (HP:0006958)1.96902000
85Short middle phalanx of the 5th finger (HP:0004220)1.96417241
86Abnormality of the Achilles tendon (HP:0005109)1.95785578
87Decreased central vision (HP:0007663)1.95556389
88Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95313673
89Abnormality of DNA repair (HP:0003254)1.93509278
90Tubulointerstitial fibrosis (HP:0005576)1.92315915
91Retinal atrophy (HP:0001105)1.92306481
92Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91768001
93Trismus (HP:0000211)1.91104757
94Hyperammonemia (HP:0001987)1.90810854
95Neoplasm of head and neck (HP:0012288)1.89678077
96Esophageal neoplasm (HP:0100751)1.89678077
97Abnormal gallbladder physiology (HP:0012438)1.88938921
98Cholecystitis (HP:0001082)1.88938921
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88461947
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88461947
101Postaxial foot polydactyly (HP:0001830)1.86740867
102Acute necrotizing encephalopathy (HP:0006965)1.85819798
103Progressive external ophthalmoplegia (HP:0000590)1.85261411
104Alkalosis (HP:0001948)1.84587803
105Increased CSF lactate (HP:0002490)1.82938306
106Premature ovarian failure (HP:0008209)1.82403557
107Abnormality of the preputium (HP:0100587)1.81944986
108Deep philtrum (HP:0002002)1.81882327
109Abnormality of the umbilical cord (HP:0010881)1.80256950
110Abnormal umbilical cord blood vessels (HP:0011403)1.79247557
111Single umbilical artery (HP:0001195)1.79247557
112Abnormality of the fetal cardiovascular system (HP:0010948)1.79247557
113Down-sloping shoulders (HP:0200021)1.76781687
114Reticulocytosis (HP:0001923)1.75937258
115Hypoparathyroidism (HP:0000829)1.75929579
116Increased intramyocellular lipid droplets (HP:0012240)1.75790761
117Congenital hepatic fibrosis (HP:0002612)1.75197226
118Ankyloglossia (HP:0010296)1.74474079
119Pancreatic fibrosis (HP:0100732)1.73302953
120Hyperthyroidism (HP:0000836)1.73235247
121Increased serum lactate (HP:0002151)1.73197817
122Protrusio acetabuli (HP:0003179)1.72788160
123Secondary amenorrhea (HP:0000869)1.71342507
124Abnormalities of placenta or umbilical cord (HP:0001194)1.71224397
125Polydipsia (HP:0001959)1.70399337
126Abnormal drinking behavior (HP:0030082)1.70399337
127Albinism (HP:0001022)1.70199944
128Acute encephalopathy (HP:0006846)1.69917672
129Osteolytic defects of the hand bones (HP:0009699)1.69569246
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.69569246
131Ureteral duplication (HP:0000073)1.69228037
132Nuclear cataract (HP:0100018)1.68938353
133Respiratory difficulties (HP:0002880)1.68521947
134Stage 5 chronic kidney disease (HP:0003774)1.68016417
135Exercise intolerance (HP:0003546)1.67055740
136Hypergonadotropic hypogonadism (HP:0000815)1.66337231
137Selective tooth agenesis (HP:0001592)1.65695613
138Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65650382
139Fibular hypoplasia (HP:0003038)1.64830091
140Bile duct proliferation (HP:0001408)1.64206413
141Abnormal biliary tract physiology (HP:0012439)1.64206413
142Redundant skin (HP:0001582)1.63880990
143Paraparesis (HP:0002385)1.62887270
144Squamous cell carcinoma (HP:0002860)1.62735127
145Abnormality of renal excretion (HP:0011036)1.62056350
146Spastic tetraparesis (HP:0001285)1.60923266
147Abnormality of the renal cortex (HP:0011035)1.59649327
148Choroideremia (HP:0001139)1.59325687
149Asymmetric septal hypertrophy (HP:0001670)1.55135659
150Oculomotor apraxia (HP:0000657)1.54026397
151Abnormality of the dental root (HP:0006486)1.51564736
152Taurodontia (HP:0000679)1.51564736
153Abnormality of permanent molar morphology (HP:0011071)1.51564736
154Facial cleft (HP:0002006)1.51332540
155Congenital malformation of the right heart (HP:0011723)1.49778264
156Double outlet right ventricle (HP:0001719)1.49778264
157Short ribs (HP:0000773)1.49592660
158Heterotopia (HP:0002282)1.47269582
159Renal dysplasia (HP:0000110)1.44853549
160Postaxial hand polydactyly (HP:0001162)1.44583022
161Abnormality of the lower motor neuron (HP:0002366)1.44056599
162Microglossia (HP:0000171)1.43901935
163Cystic liver disease (HP:0006706)1.43746296
164Abnormality of molar morphology (HP:0011070)1.41507540
165Abnormality of molar (HP:0011077)1.41507540
166Abnormality of the dental pulp (HP:0006479)1.41242802
167Chronic sinusitis (HP:0011109)1.41161626
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.40832411
169Aplasia/Hypoplasia of the lens (HP:0008063)1.39851799
170Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.39788673
171Hemorrhage of the eye (HP:0011885)1.38928765
172Absent frontal sinuses (HP:0002688)1.38242333
173Bundle branch block (HP:0011710)1.37131811
174Gait imbalance (HP:0002141)1.35566654
175Congenital primary aphakia (HP:0007707)1.35501346
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.35121185
177Bell-shaped thorax (HP:0001591)1.33360316
178Abnormality of dentin (HP:0010299)1.31950416
179Constricted visual fields (HP:0001133)1.30460094
180Abnormality of saccadic eye movements (HP:0000570)1.30048656
181Abnormal urine output (HP:0012590)1.28841695
182J-shaped sella turcica (HP:0002680)1.28744596
183Median cleft lip (HP:0000161)1.28408934
184Decreased electroretinogram (ERG) amplitude (HP:0000654)1.25263716
185True hermaphroditism (HP:0010459)1.24748989
186Deformed sella turcica (HP:0002681)1.23306794
187Amyotrophic lateral sclerosis (HP:0007354)1.23231433
188Optic nerve hypoplasia (HP:0000609)1.22166330
189Tongue fasciculations (HP:0001308)1.20899440
190Exercise-induced myalgia (HP:0003738)1.18525372
191Genital tract atresia (HP:0001827)1.16148726
192Abnormality of ocular smooth pursuit (HP:0000617)1.16113234
193Neurofibrillary tangles (HP:0002185)1.15295926
194Nephropathy (HP:0000112)1.14359472
195Short thorax (HP:0010306)1.12584716
196Nephrogenic diabetes insipidus (HP:0009806)1.12274737
197Vaginal atresia (HP:0000148)1.11035263
198Chronic hepatic failure (HP:0100626)1.10982200
199Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.10670302
200Supernumerary spleens (HP:0009799)1.09886137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.97764411
2PDK48.97764411
3PDK25.84713920
4TESK15.05041324
5NME24.91835070
6PRKD34.25651217
7MST1R3.73300372
8ICK3.60936721
9PBK2.97024094
10PTK2B2.23914655
11PRPF4B2.21052582
12WNK42.13454291
13STK392.12350486
14EIF2AK12.01329194
15NEK11.96888343
16MET1.76166570
17PNCK1.55188917
18STK381.54745483
19NEK21.51686271
20IRAK31.34720280
21LATS21.32358927
22DYRK1B1.30399000
23STK161.28524677
24SCYL21.24935964
25CDK71.23043229
26PDK11.19869065
27RPS6KB21.10066507
28ERBB41.09288566
29TRIB31.04956309
30ERN11.00845625
31TSSK60.96539796
32AURKB0.94268034
33EIF2AK30.93862180
34DYRK30.93426501
35CDK80.90657456
36TAOK20.90364354
37TYRO30.90314292
38KSR20.88493006
39MKNK10.85850457
40MAPK110.85457534
41AKT20.79671863
42CDK40.77573070
43WNK10.74695019
44SRPK10.74299988
45BRSK20.70970672
46TRPM70.70804601
47MAPK120.70365845
48IRAK10.69155924
49TTK0.68721855
50MAP3K80.68680924
51BMX0.67782250
52DDR20.66985696
53MAPK150.66976895
54PDPK10.66540178
55PASK0.65581405
56AKT30.65290272
57STK30.64652130
58CCNB10.64457198
59NME10.64006709
60CHEK20.63426765
61RAF10.62742811
62LMTK20.62267306
63WEE10.61567787
64TLK10.61328458
65MAP2K60.57712584
66RIPK40.57632263
67STK38L0.57486664
68BRD40.50270155
69MAP2K20.50191597
70TTN0.48354851
71ERBB30.47844173
72TESK20.46567423
73CHEK10.44564525
74LRRK20.43373152
75MAP3K10.43074239
76PINK10.42791421
77ALK0.40291480
78SMG10.40179946
79BMPR20.39598842
80EEF2K0.39279501
81SIK10.38556913
82ILK0.38260299
83CAMK1G0.37804160
84PAK10.37712823
85IRAK20.37321631
86CSNK1E0.36549701
87MAP2K10.35886558
88PIM10.34779123
89BRSK10.34479341
90PRKCG0.34472970
91MAPK140.34406022
92MUSK0.34182534
93PLK40.33735326
94NTRK20.32698592
95MAP3K60.32361587
96MAPKAPK50.30568408
97MAP3K120.30425102
98ABL20.30160499
99ATM0.29039454
100CDC70.28037279
101MAPK70.27571197
102RIPK10.27497210
103PLK10.27357362
104MAPK100.26175983
105MAP3K100.26037702
106PIM20.25765123
107ATR0.25666914
108NEK60.23496359
109AKT10.22967124
110MARK30.22695553
111PAK20.22483227
112MARK20.17444764
113PRKAA10.16095661
114CDK150.15880310
115STK100.14951994
116PRKCZ0.14389108
117MAP2K70.14367402
118MTOR0.14154920
119PKN10.13674089
120RPS6KB10.13322139
121CDK180.13048300
122PRKCQ0.13008376
123CAMKK10.12910896
124CDK11A0.12280212
125PRKG20.10643728
126PAK40.10377712
127CSNK2A10.09967518
128BRAF0.09348039
129CDK140.08570011
130PRKG10.08172713
131ZAP700.08045399
132AURKA0.07524635
133CDK10.06829751
134GSK3B0.06658995
135CSNK2A20.06424825
136PDGFRB0.05793104
137CSF1R0.05382988
138CDK20.05335256
139STK110.05300528
140CLK10.05090026
141MAP3K40.04672481
142BUB10.04345811
143PRKACG0.04331859
144CAMK2A0.04221887
145MAPK80.04195377
146CSNK1D0.03813754
147RPS6KA10.03527177
148PRKCD0.02379455
149CDK120.02046435
150PRKCB0.01081883
151PRKCA0.00871337
152CDK30.00730731
153RPS6KA3-0.0246844
154OXSR1-0.0203187
155PRKACA-0.0159382
156PRKACB-0.0118009
157CDK6-0.0062371
158WNK3-0.0012453
159PRKDC-0.0009939

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46065335
2Vitamin B6 metabolism_Homo sapiens_hsa007504.42628280
3Fatty acid biosynthesis_Homo sapiens_hsa000614.20899309
4DNA replication_Homo sapiens_hsa030304.00628381
5Ribosome_Homo sapiens_hsa030103.85207897
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.78846978
7Pyruvate metabolism_Homo sapiens_hsa006203.66720705
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86411862
9Propanoate metabolism_Homo sapiens_hsa006402.85779864
10Linoleic acid metabolism_Homo sapiens_hsa005912.82361613
11Basal transcription factors_Homo sapiens_hsa030222.73229445
12Mismatch repair_Homo sapiens_hsa034302.72519097
13Glucagon signaling pathway_Homo sapiens_hsa049222.60040531
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.53041235
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44698605
16Pentose phosphate pathway_Homo sapiens_hsa000302.44696647
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25154531
18Non-homologous end-joining_Homo sapiens_hsa034502.11121290
19Spliceosome_Homo sapiens_hsa030402.05656640
20Glycosaminoglycan degradation_Homo sapiens_hsa005312.04912181
21Nucleotide excision repair_Homo sapiens_hsa034202.01040090
22One carbon pool by folate_Homo sapiens_hsa006701.96770501
23Glycerolipid metabolism_Homo sapiens_hsa005611.90706301
24Arginine biosynthesis_Homo sapiens_hsa002201.90674610
25Sulfur relay system_Homo sapiens_hsa041221.89886959
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88264136
27Oocyte meiosis_Homo sapiens_hsa041141.87330901
28Base excision repair_Homo sapiens_hsa034101.87309393
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82443472
30Selenocompound metabolism_Homo sapiens_hsa004501.81044524
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77478617
32PPAR signaling pathway_Homo sapiens_hsa033201.72146318
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68161114
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.61002915
35RNA polymerase_Homo sapiens_hsa030201.59080143
36Mineral absorption_Homo sapiens_hsa049781.53612395
37N-Glycan biosynthesis_Homo sapiens_hsa005101.52930725
38Fanconi anemia pathway_Homo sapiens_hsa034601.48811042
39Carbon metabolism_Homo sapiens_hsa012001.47296931
40Amphetamine addiction_Homo sapiens_hsa050311.47252274
41Ether lipid metabolism_Homo sapiens_hsa005651.40328317
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37991243
43Oxidative phosphorylation_Homo sapiens_hsa001901.37400302
44Fructose and mannose metabolism_Homo sapiens_hsa000511.35686159
45Fat digestion and absorption_Homo sapiens_hsa049751.31697003
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30600788
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29449873
48Cardiac muscle contraction_Homo sapiens_hsa042601.27363913
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.25454271
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22758720
51Parkinsons disease_Homo sapiens_hsa050121.21915096
52Bladder cancer_Homo sapiens_hsa052191.20187144
53Dorso-ventral axis formation_Homo sapiens_hsa043201.17180294
54Fatty acid metabolism_Homo sapiens_hsa012121.15850291
55Purine metabolism_Homo sapiens_hsa002301.15639238
56Phenylalanine metabolism_Homo sapiens_hsa003601.15358545
57Fatty acid degradation_Homo sapiens_hsa000711.15208700
58Biosynthesis of amino acids_Homo sapiens_hsa012301.14633331
59mRNA surveillance pathway_Homo sapiens_hsa030151.14519046
60Renin secretion_Homo sapiens_hsa049241.12669807
61Huntingtons disease_Homo sapiens_hsa050161.09849359
62Tyrosine metabolism_Homo sapiens_hsa003501.09523365
63RNA transport_Homo sapiens_hsa030131.02749875
64Proteasome_Homo sapiens_hsa030501.01849202
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01162484
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99358002
67Galactose metabolism_Homo sapiens_hsa000520.98631834
68Alzheimers disease_Homo sapiens_hsa050100.96224418
69Small cell lung cancer_Homo sapiens_hsa052220.96207156
70Other glycan degradation_Homo sapiens_hsa005110.94987690
71Renin-angiotensin system_Homo sapiens_hsa046140.94856864
72Glutathione metabolism_Homo sapiens_hsa004800.94224900
73Non-small cell lung cancer_Homo sapiens_hsa052230.93806419
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91729112
75Chronic myeloid leukemia_Homo sapiens_hsa052200.87330323
76Antigen processing and presentation_Homo sapiens_hsa046120.84717576
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83131975
78Basal cell carcinoma_Homo sapiens_hsa052170.81991192
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81292362
80Collecting duct acid secretion_Homo sapiens_hsa049660.81191763
81Chemical carcinogenesis_Homo sapiens_hsa052040.77261854
82Pancreatic cancer_Homo sapiens_hsa052120.76879148
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76393056
84MicroRNAs in cancer_Homo sapiens_hsa052060.76289265
85Thyroid cancer_Homo sapiens_hsa052160.76133250
86Insulin secretion_Homo sapiens_hsa049110.74568468
87Arachidonic acid metabolism_Homo sapiens_hsa005900.74202894
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68507327
89Bile secretion_Homo sapiens_hsa049760.67609069
90Long-term potentiation_Homo sapiens_hsa047200.67240260
91Hedgehog signaling pathway_Homo sapiens_hsa043400.66513252
92Thyroid hormone synthesis_Homo sapiens_hsa049180.66325069
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66242305
94Lysine degradation_Homo sapiens_hsa003100.64294198
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63834158
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.62595364
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.61978028
98Folate biosynthesis_Homo sapiens_hsa007900.59114805
99Sulfur metabolism_Homo sapiens_hsa009200.57635166
100Estrogen signaling pathway_Homo sapiens_hsa049150.57151269
101HTLV-I infection_Homo sapiens_hsa051660.56906874
102Calcium signaling pathway_Homo sapiens_hsa040200.54497430
103Taste transduction_Homo sapiens_hsa047420.50895774
104Pancreatic secretion_Homo sapiens_hsa049720.50459774
105Melanogenesis_Homo sapiens_hsa049160.50109769
106TGF-beta signaling pathway_Homo sapiens_hsa043500.48659940
107Systemic lupus erythematosus_Homo sapiens_hsa053220.48116137
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.47996258
109p53 signaling pathway_Homo sapiens_hsa041150.47624591
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47553475
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45807979
112Protein digestion and absorption_Homo sapiens_hsa049740.45001983
113Endometrial cancer_Homo sapiens_hsa052130.44733669
114Salivary secretion_Homo sapiens_hsa049700.44717611
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44349544
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43451042
117Viral carcinogenesis_Homo sapiens_hsa052030.42928138
118Metabolic pathways_Homo sapiens_hsa011000.42088203
119Inositol phosphate metabolism_Homo sapiens_hsa005620.42087642
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41723552
121Vibrio cholerae infection_Homo sapiens_hsa051100.41473299
122ABC transporters_Homo sapiens_hsa020100.41428456
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41268278
124Lysosome_Homo sapiens_hsa041420.40628597
125Glioma_Homo sapiens_hsa052140.40451919
126Renal cell carcinoma_Homo sapiens_hsa052110.40105340
127Legionellosis_Homo sapiens_hsa051340.39428440
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38572334
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38399982
130HIF-1 signaling pathway_Homo sapiens_hsa040660.38377231
131Endocytosis_Homo sapiens_hsa041440.37524846
132Acute myeloid leukemia_Homo sapiens_hsa052210.37370598
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.36502972
134mTOR signaling pathway_Homo sapiens_hsa041500.36354268
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35745858
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35085529
137AMPK signaling pathway_Homo sapiens_hsa041520.34618743
138Hepatitis B_Homo sapiens_hsa051610.34492802
139Melanoma_Homo sapiens_hsa052180.34094385
140Synaptic vesicle cycle_Homo sapiens_hsa047210.32773035
141Proteoglycans in cancer_Homo sapiens_hsa052050.32096099
142Gastric acid secretion_Homo sapiens_hsa049710.32008376
143Prostate cancer_Homo sapiens_hsa052150.31216201
144Fatty acid elongation_Homo sapiens_hsa000620.31126048
145Hippo signaling pathway_Homo sapiens_hsa043900.30939131
146Insulin signaling pathway_Homo sapiens_hsa049100.30437168
147cAMP signaling pathway_Homo sapiens_hsa040240.30289898
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29306479
149Pyrimidine metabolism_Homo sapiens_hsa002400.29036319
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28127651
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26349447
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26342549
153Epstein-Barr virus infection_Homo sapiens_hsa051690.26299365
154Cell cycle_Homo sapiens_hsa041100.25646381
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24593563
156Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24589922
157Circadian entrainment_Homo sapiens_hsa047130.24206985
158VEGF signaling pathway_Homo sapiens_hsa043700.24182006
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20483319
160Alcoholism_Homo sapiens_hsa050340.17598059
161Cocaine addiction_Homo sapiens_hsa050300.17261690
162Homologous recombination_Homo sapiens_hsa034400.14056790
163RNA degradation_Homo sapiens_hsa030180.11902897
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11482041
165Glutamatergic synapse_Homo sapiens_hsa047240.09378945
166Wnt signaling pathway_Homo sapiens_hsa043100.08581162
167Steroid hormone biosynthesis_Homo sapiens_hsa001400.05665931

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