CTAGE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein targeting to Golgi (GO:0000042)9.45443986
2establishment of protein localization to Golgi (GO:0072600)9.09253532
3retrograde transport, vesicle recycling within Golgi (GO:0000301)8.80581707
4chromosome condensation (GO:0030261)8.48012372
5DNA packaging (GO:0006323)8.19444368
6protein polyglutamylation (GO:0018095)7.93236637
7plasma membrane fusion (GO:0045026)7.70292838
8microtubule depolymerization (GO:0007019)7.63358412
9spermatid development (GO:0007286)7.48478671
10rRNA methylation (GO:0031167)7.47105510
11sperm capacitation (GO:0048240)7.19606121
12microtubule polymerization or depolymerization (GO:0031109)7.13936656
13centriole replication (GO:0007099)7.08646837
14protein localization to Golgi apparatus (GO:0034067)6.92997498
15sperm-egg recognition (GO:0035036)6.88502697
16single strand break repair (GO:0000012)6.84636929
17spermatid nucleus differentiation (GO:0007289)6.71472384
18response to pheromone (GO:0019236)6.65577823
19multicellular organism reproduction (GO:0032504)6.62034957
20spermatogenesis (GO:0007283)6.61124066
21male gamete generation (GO:0048232)6.59070814
22calcium ion-dependent exocytosis (GO:0017156)6.30528731
23binding of sperm to zona pellucida (GO:0007339)6.29995796
24rRNA modification (GO:0000154)6.27237922
25seminiferous tubule development (GO:0072520)6.26712290
26regulation of centriole replication (GO:0046599)6.14780143
27centriole assembly (GO:0098534)6.13848529
28gamete generation (GO:0007276)6.08221401
29reproduction (GO:0000003)6.00092635
30axonemal dynein complex assembly (GO:0070286)5.92615386
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.91766541
32cell-cell recognition (GO:0009988)5.60964500
33microtubule severing (GO:0051013)5.58991208
34single fertilization (GO:0007338)5.57580412
35glomerular visceral epithelial cell development (GO:0072015)5.57451929
36phosphatidylethanolamine metabolic process (GO:0046337)5.47093178
37RNA destabilization (GO:0050779)5.30046107
38sexual reproduction (GO:0019953)5.17662013
39glomerular epithelial cell development (GO:0072310)5.13659478
40negative regulation of inclusion body assembly (GO:0090084)5.12214137
41fertilization (GO:0009566)5.08202261
42regulation of cilium movement (GO:0003352)5.00706027
43motile cilium assembly (GO:0044458)4.97808705
44multicellular organismal reproductive process (GO:0048609)4.83438033
45epithelial cilium movement (GO:0003351)4.82144811
46cilium or flagellum-dependent cell motility (GO:0001539)4.81916749
47microtubule nucleation (GO:0007020)4.59317792
48germ cell development (GO:0007281)4.55916749
49cellular ketone body metabolic process (GO:0046950)4.45085244
50musculoskeletal movement (GO:0050881)4.41293663
51multicellular organismal movement (GO:0050879)4.41293663
52regulation of Rab GTPase activity (GO:0032313)4.33761281
53positive regulation of Rab GTPase activity (GO:0032851)4.33761281
54cilium movement (GO:0003341)4.24725793
55cellular process involved in reproduction in multicellular organism (GO:0022412)4.23530812
56cell wall macromolecule catabolic process (GO:0016998)4.09252657
57histone H3-K9 demethylation (GO:0033169)4.04795703
58piRNA metabolic process (GO:0034587)4.02720680
59axoneme assembly (GO:0035082)3.95006837
60nucleus organization (GO:0006997)3.93626725
61ketone body metabolic process (GO:1902224)3.90676041
62cell wall macromolecule metabolic process (GO:0044036)3.88469893
63intra-Golgi vesicle-mediated transport (GO:0006891)3.82756577
64glycerol ether metabolic process (GO:0006662)3.81725974
65nuclear pore complex assembly (GO:0051292)3.81151655
66male meiosis I (GO:0007141)3.72330318
67male meiosis (GO:0007140)3.64142539
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58221791
69ether metabolic process (GO:0018904)3.55590104
70regulation of inclusion body assembly (GO:0090083)3.55346228
71DNA methylation involved in gamete generation (GO:0043046)3.54495781
72regulation of transcription involved in cell fate commitment (GO:0060850)3.51289839
73membrane protein intracellular domain proteolysis (GO:0031293)3.39294113
74chromatin silencing (GO:0006342)3.35845951
75negative regulation of Rho protein signal transduction (GO:0035024)3.32915817
76ventricular system development (GO:0021591)3.04224434
77regulation of microtubule-based movement (GO:0060632)3.02339052
78organic cation transport (GO:0015695)2.99867771
79pore complex assembly (GO:0046931)2.93425029
80RNA methylation (GO:0001510)2.90110683
81multicellular organismal development (GO:0007275)2.89779779
82RNA localization (GO:0006403)2.86743071
83synapsis (GO:0007129)2.86554623
84nuclear pore organization (GO:0006999)2.86016357
85regulation of meiosis I (GO:0060631)2.85912660
86detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.85605592
87protein depolymerization (GO:0051261)2.81040574
88meiosis I (GO:0007127)2.80023310
89receptor recycling (GO:0001881)2.74582054
90tRNA methylation (GO:0030488)2.74540740
91coenzyme catabolic process (GO:0009109)2.74235052
92cell recognition (GO:0008037)2.72613028
93Golgi to endosome transport (GO:0006895)2.70100795
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69540193
95homeostasis of number of cells within a tissue (GO:0048873)2.69528254
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69090540
97regulation of interleukin-13 production (GO:0032656)2.68423022
98sperm motility (GO:0030317)11.6578097
99acrosome reaction (GO:0007340)10.9633556
100fusion of sperm to egg plasma membrane (GO:0007342)10.1459781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.18102845
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18491967
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70091467
4FUS_26573619_Chip-Seq_HEK293_Human2.61919378
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52238181
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45299647
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.39239186
8CBP_20019798_ChIP-Seq_JUKART_Human2.39239186
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38644585
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33926241
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.33926241
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20246814
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.92947149
14EZH2_22144423_ChIP-Seq_EOC_Human1.90899473
15ER_23166858_ChIP-Seq_MCF-7_Human1.87390813
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80399849
17RAC3_21632823_ChIP-Seq_H3396_Human1.76361296
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74947694
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74163379
20SMAD4_21741376_ChIP-Seq_EPCs_Human1.73141102
21VDR_22108803_ChIP-Seq_LS180_Human1.71777104
22ZNF274_21170338_ChIP-Seq_K562_Hela1.71009378
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.67443210
24DROSHA_22980978_ChIP-Seq_HELA_Human1.62817579
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.62321271
26MYC_19829295_ChIP-Seq_ESCs_Human1.62151322
27ERA_21632823_ChIP-Seq_H3396_Human1.61214619
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60680636
29* P300_19829295_ChIP-Seq_ESCs_Human1.58874793
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.58251092
31TAF15_26573619_Chip-Seq_HEK293_Human1.54893683
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.53622401
33CBX2_22325352_ChIP-Seq_293T-Rex_Human1.52591955
34HNFA_21074721_ChIP-Seq_CACO-2_Human1.52444250
35TAF2_19829295_ChIP-Seq_ESCs_Human1.50869226
36RBPJ_21746931_ChIP-Seq_IB4_Human1.50671731
37* AR_25329375_ChIP-Seq_VCAP_Human1.50379386
38SMAD4_21799915_ChIP-Seq_A2780_Human1.43618406
39CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.43500763
40NANOG_20526341_ChIP-Seq_ESCs_Human1.43447560
41ETV1_20927104_ChIP-Seq_GIST48_Human1.42728949
42NFYB_21822215_ChIP-Seq_K562_Human1.42495178
43GBX2_23144817_ChIP-Seq_PC3_Human1.41416259
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38208508
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36623773
46TBL1_22424771_ChIP-Seq_293T_Human1.36442796
47PHF8_20622853_ChIP-Seq_HELA_Human1.35562814
48* STAT3_23295773_ChIP-Seq_U87_Human1.35100393
49TP53_18474530_ChIP-ChIP_U2OS_Human1.34727537
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32874098
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32855939
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.32800693
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32336740
54ERG_20517297_ChIP-Seq_VCAP_Human1.31492978
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31332722
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30553740
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30320272
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29665181
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29002049
60OCT4_20526341_ChIP-Seq_ESCs_Human1.28799662
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27232745
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.26847786
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26744962
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.25984627
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.25622604
66SMAD3_21741376_ChIP-Seq_ESCs_Human1.24594575
67* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24098463
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23459213
69CEBPB_22108803_ChIP-Seq_LS180_Human1.22833552
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21260120
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.19437265
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18977372
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.17871717
74NANOG_19829295_ChIP-Seq_ESCs_Human1.17497825
75SOX2_19829295_ChIP-Seq_ESCs_Human1.17497825
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.17223888
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.16584050
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16102145
79NFYA_21822215_ChIP-Seq_K562_Human1.15897023
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13272522
81KDM2B_26808549_Chip-Seq_REH_Human1.13231561
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.13159304
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.12962489
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12000791
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11550294
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.11550294
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.10328247
88CTCF_27219007_Chip-Seq_Bcells_Human1.10299731
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07345626
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07043517
91HOXB7_26014856_ChIP-Seq_BT474_Human1.06224210
92CTCF_20526341_ChIP-Seq_ESCs_Human1.05136162
93TCF4_23295773_ChIP-Seq_U87_Human1.04832046
94* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04816396
95SALL4_22934838_ChIP-ChIP_CD34+_Human1.03616404
96NCOR_22424771_ChIP-Seq_293T_Human1.02013864
97P53_21459846_ChIP-Seq_SAOS-2_Human1.00750236
98BCL6_27268052_Chip-Seq_Bcells_Human0.99839557
99SMRT_27268052_Chip-Seq_Bcells_Human0.99683497
100TP63_22573176_ChIP-Seq_HFKS_Human0.99533083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.61561352
2MP0003878_abnormal_ear_physiology5.61561352
3MP0003698_abnormal_male_reproductive4.14072408
4MP0005670_abnormal_white_adipose4.04477983
5MP0001929_abnormal_gametogenesis3.83275356
6MP0001348_abnormal_lacrimal_gland3.25331153
7MP0005379_endocrine/exocrine_gland_phen2.64100180
8MP0003646_muscle_fatigue2.50398633
9MP0002161_abnormal_fertility/fecundity2.24344715
10MP0003718_maternal_effect2.14141015
11MP0001485_abnormal_pinna_reflex2.05667066
12MP0005410_abnormal_fertilization10.9582507
13MP0003011_delayed_dark_adaptation1.93365422
14MP0005310_abnormal_salivary_gland1.93291607
15MP0008877_abnormal_DNA_methylation1.92539076
16MP0001486_abnormal_startle_reflex1.91531133
17MP0002210_abnormal_sex_determination1.89835788
18MP0003879_abnormal_hair_cell1.89379907
19MP0005451_abnormal_body_composition1.74696153
20MP0000678_abnormal_parathyroid_gland1.68173609
21MP0004742_abnormal_vestibular_system1.63489966
22MP0005423_abnormal_somatic_nervous1.54275205
23MP0001145_abnormal_male_reproductive1.50090893
24MP0000653_abnormal_sex_gland1.45161349
25MP0005551_abnormal_eye_electrophysiolog1.36348336
26MP0001984_abnormal_olfaction1.33470533
27MP0001963_abnormal_hearing_physiology1.29998221
28MP0001765_abnormal_ion_homeostasis1.23826865
29MP0005253_abnormal_eye_physiology1.22231703
30MP0002132_abnormal_respiratory_system1.19720780
31MP0002138_abnormal_hepatobiliary_system1.16477237
32MP0002282_abnormal_trachea_morphology1.07752381
33MP0001968_abnormal_touch/_nociception1.07253430
34MP0009697_abnormal_copulation1.03249996
35MP0004510_myositis1.00580601
36MP0009115_abnormal_fat_cell0.95951047
37MP0000026_abnormal_inner_ear0.95682068
38MP0002229_neurodegeneration0.95441597
39MP0001501_abnormal_sleep_pattern0.93399879
40MP0000230_abnormal_systemic_arterial0.91184402
41MP0005395_other_phenotype0.90912980
42MP0002735_abnormal_chemical_nociception0.89326360
43MP0002234_abnormal_pharynx_morphology0.88930983
44MP0002067_abnormal_sensory_capabilities0.87237358
45MP0004085_abnormal_heartbeat0.85787494
46MP0003137_abnormal_impulse_conducting0.84607984
47MP0002837_dystrophic_cardiac_calcinosis0.84457119
48MP0002127_abnormal_cardiovascular_syste0.83927495
49MP0010329_abnormal_lipoprotein_level0.81043491
50MP0005645_abnormal_hypothalamus_physiol0.80710849
51MP0008995_early_reproductive_senescence0.79548801
52MP0002272_abnormal_nervous_system0.78332886
53MP0006276_abnormal_autonomic_nervous0.78110995
54MP0002557_abnormal_social/conspecific_i0.77644769
55MP0004859_abnormal_synaptic_plasticity0.77461651
56MP0002572_abnormal_emotion/affect_behav0.74401227
57MP0005084_abnormal_gallbladder_morpholo0.74077710
58MP0002928_abnormal_bile_duct0.73915703
59MP0002249_abnormal_larynx_morphology0.73389606
60MP0005332_abnormal_amino_acid0.72926332
61MP0000516_abnormal_urinary_system0.72101514
62MP0005367_renal/urinary_system_phenotyp0.72101514
63MP0002733_abnormal_thermal_nociception0.71482941
64MP0009745_abnormal_behavioral_response0.69892424
65MP0005636_abnormal_mineral_homeostasis0.67580822
66MP0000955_abnormal_spinal_cord0.67385190
67MP0001666_abnormal_nutrient_absorption0.67139366
68MP0009046_muscle_twitch0.66009765
69MP0005167_abnormal_blood-brain_barrier0.64534316
70MP0005248_abnormal_Harderian_gland0.61864688
71MP0001905_abnormal_dopamine_level0.61424077
72MP0000534_abnormal_ureter_morphology0.60734876
73MP0009053_abnormal_anal_canal0.60544431
74MP0002693_abnormal_pancreas_physiology0.60428688
75MP0004036_abnormal_muscle_relaxation0.59110650
76MP0001440_abnormal_grooming_behavior0.56158578
77MP0005535_abnormal_body_temperature0.55007537
78MP0008775_abnormal_heart_ventricle0.54276296
79MP0001986_abnormal_taste_sensitivity0.51572162
80MP0001970_abnormal_pain_threshold0.51528083
81MP0004484_altered_response_of0.50528427
82MP0001944_abnormal_pancreas_morphology0.49513283
83MP0004084_abnormal_cardiac_muscle0.49409214
84MP0002163_abnormal_gland_morphology0.49158321
85MP0005595_abnormal_vascular_smooth0.49077175
86MP0009643_abnormal_urine_homeostasis0.48235326
87MP0008961_abnormal_basal_metabolism0.46505092
88MP0005083_abnormal_biliary_tract0.45780471
89MP0005623_abnormal_meninges_morphology0.45501008
90MP0002136_abnormal_kidney_physiology0.45224147
91MP0004233_abnormal_muscle_weight0.44062326
92MP0002269_muscular_atrophy0.44022778
93MP0000681_abnormal_thyroid_gland0.43806968
94MP0005666_abnormal_adipose_tissue0.43225696
95MP0002876_abnormal_thyroid_physiology0.42810762
96MP0002734_abnormal_mechanical_nocicepti0.42479093
97MP0005391_vision/eye_phenotype0.42087687
98MP0006292_abnormal_olfactory_placode0.39262881
99MP0006072_abnormal_retinal_apoptosis0.39210532
100MP0002971_abnormal_brown_adipose0.38909922

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.88896803
2Tubulointerstitial nephritis (HP:0001970)6.61595878
3Severe visual impairment (HP:0001141)6.43412252
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.28621533
5Absent/shortened dynein arms (HP:0200106)6.28621533
6Asymmetric septal hypertrophy (HP:0001670)5.45040934
7Abnormal ciliary motility (HP:0012262)4.72976758
8Cone-rod dystrophy (HP:0000548)4.70425839
9Abnormal respiratory motile cilium physiology (HP:0012261)4.66137494
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56957986
11Hyperkalemia (HP:0002153)4.55415035
12Attenuation of retinal blood vessels (HP:0007843)4.48761183
13Male infertility (HP:0003251)4.28814152
14Bony spicule pigmentary retinopathy (HP:0007737)4.23386054
15Abnormal respiratory motile cilium morphology (HP:0005938)4.20782362
16Abnormal respiratory epithelium morphology (HP:0012253)4.20782362
17Abnormality of macular pigmentation (HP:0008002)4.16948342
18Nasal polyposis (HP:0100582)4.14393970
19Menstrual irregularities (HP:0000858)4.06855432
20Resting tremor (HP:0002322)4.03651797
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.96843319
22Abnormality of dental color (HP:0011073)3.94600057
23Amelogenesis imperfecta (HP:0000705)3.69604606
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.66551977
25Insulin-resistant diabetes mellitus (HP:0000831)3.62536215
26Infertility (HP:0000789)3.59405901
27Progressive sensorineural hearing impairment (HP:0000408)3.52088058
28Hypoalphalipoproteinemia (HP:0003233)3.48905527
29Hypoplasia of the thymus (HP:0000778)3.35679300
30Abnormality of the nasal mucosa (HP:0000433)3.32751143
31Stage 5 chronic kidney disease (HP:0003774)3.29153063
32Progressive cerebellar ataxia (HP:0002073)3.28180724
33Truncal obesity (HP:0001956)3.25053493
34Portal hypertension (HP:0001409)3.22434221
35Facial shape deformation (HP:0011334)3.15605314
36Potter facies (HP:0002009)3.15605314
37Tubulointerstitial abnormality (HP:0001969)3.13071369
38Abnormal rod and cone electroretinograms (HP:0008323)3.02759543
39Rhinitis (HP:0012384)3.01670539
40Nephronophthisis (HP:0000090)2.97449904
41Abnormality of the hepatic vasculature (HP:0006707)2.94439575
42Impulsivity (HP:0100710)2.91188042
43Polydipsia (HP:0001959)2.83346590
44Abnormal drinking behavior (HP:0030082)2.83346590
45Renovascular hypertension (HP:0100817)2.77868312
46Hypoalbuminemia (HP:0003073)2.74179314
47Abnormal albumin level (HP:0012116)2.74179314
48Abnormal spermatogenesis (HP:0008669)2.68430360
49Abnormal urine output (HP:0012590)2.64979132
50Abnormality of the renal medulla (HP:0100957)2.62330602
51Subcapsular cataract (HP:0000523)2.60057643
52Enlarged epiphyses (HP:0010580)2.57246995
53Abnormality of potassium homeostasis (HP:0011042)2.55364456
54Focal segmental glomerulosclerosis (HP:0000097)2.54415233
55Postural instability (HP:0002172)2.51253522
56Chronic bronchitis (HP:0004469)2.47103033
57Generalized aminoaciduria (HP:0002909)2.45977719
58Hyperuricemia (HP:0002149)2.39238122
59Increased purine levels (HP:0004368)2.39238122
60Intellectual disability, moderate (HP:0002342)2.38550438
61Abnormality of the costochondral junction (HP:0000919)2.37571813
62Hypoplastic ischia (HP:0003175)2.37443812
63Abnormality of renal excretion (HP:0011036)2.37167343
64Unilateral renal agenesis (HP:0000122)2.36733335
65Progressive hearing impairment (HP:0001730)2.36581222
66Azoospermia (HP:0000027)2.30186044
67Congenital sensorineural hearing impairment (HP:0008527)2.29756838
68Bell-shaped thorax (HP:0001591)2.24516279
69Renal Fanconi syndrome (HP:0001994)2.22974808
70Ventricular tachycardia (HP:0004756)2.22375719
71Polyuria (HP:0000103)2.22230058
72Glycosuria (HP:0003076)2.21411985
73Abnormality of urine glucose concentration (HP:0011016)2.21411985
74Decreased central vision (HP:0007663)2.21275382
75Abnormality of the ischium (HP:0003174)2.14134684
76Bronchiectasis (HP:0002110)2.09691946
77Osteomalacia (HP:0002749)2.06185975
78Tubular atrophy (HP:0000092)2.03757093
79Glomerulosclerosis (HP:0000096)2.01663317
80Pancreatic fibrosis (HP:0100732)1.98570120
81Optic nerve hypoplasia (HP:0000609)1.97933798
82Abnormality of purine metabolism (HP:0004352)1.96430112
83Insulin resistance (HP:0000855)1.95369547
84Myokymia (HP:0002411)1.94546277
85Congenital malformation of the right heart (HP:0011723)1.86245079
86Double outlet right ventricle (HP:0001719)1.86245079
87Hyponatremia (HP:0002902)1.85375845
88Pendular nystagmus (HP:0012043)1.83243923
89Hypophosphatemic rickets (HP:0004912)1.82148432
90Widely patent fontanelles and sutures (HP:0004492)1.82016058
91Hypolipoproteinemia (HP:0010981)1.81299889
92Hypergonadotropic hypogonadism (HP:0000815)1.77116271
93Growth hormone deficiency (HP:0000824)1.74728690
94Photophobia (HP:0000613)1.74302446
95Bilateral sensorineural hearing impairment (HP:0008619)1.73778805
96Abnormality of chloride homeostasis (HP:0011422)1.73733179
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73692716
98Horizontal nystagmus (HP:0000666)1.72952687
99Bradycardia (HP:0001662)1.72472610
100Sandal gap (HP:0001852)1.71979768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.83998763
2INSRR5.65493652
3BRD44.45651001
4PLK23.84735127
5TESK13.54725589
6PNCK3.46201038
7MAP4K23.19570765
8PIK3CG2.98566904
9CAMK1G2.30520091
10DDR22.26967961
11STK38L2.09769192
12STK381.89833578
13TYRO31.78957012
14PRKD31.52110598
15PTK2B1.48693397
16WNK11.43536204
17PDK11.42377561
18CDK121.40317527
19NEK61.38782055
20FRK1.29049416
21TIE11.25007240
22PDPK11.24124956
23MAPK151.22906281
24AKT30.90847253
25WNK40.85657678
26MST1R0.83777333
27MAP3K40.82433646
28DYRK1B0.79516082
29STK390.79344853
30CDK70.68839257
31PRKG20.66870900
32MAP2K70.65962095
33CAMK10.60979425
34PRKAA20.60136459
35TNIK0.58798573
36PRKG10.56776345
37BLK0.55530792
38CAMK1D0.54043397
39TRPM70.53883724
40MARK10.51966701
41BMPR1B0.51740170
42MAP3K110.51448486
43NTRK30.50574023
44BRAF0.49782930
45CDK30.49681411
46OXSR10.47112775
47SIK20.44930792
48ADRBK20.43789330
49LATS20.42597961
50ROCK10.37052129
51SGK2230.35991777
52SGK4940.35991777
53PRKCG0.35141420
54MAP2K20.34581762
55TAOK30.33569682
56MAPK10.32129834
57GSK3B0.32055848
58CDK10.31724736
59BRSK20.30389771
60RPS6KA20.30239347
61CAMK40.29299176
62SGK10.27765386
63ACVR1B0.26182727
64CDK20.26062702
65TXK0.25912216
66RPS6KA10.25640718
67MUSK0.24898653
68MAP3K20.24304408
69SGK20.24168513
70BRSK10.24024403
71MYLK0.23550984
72PRKCZ0.22519996
73PINK10.21112544
74PRKACA0.19739755
75JAK30.18946272
76KSR20.18939269
77MAPKAPK30.18910521
78GRK70.18476598
79VRK10.17736113
80MAPK80.17462988
81CAMK2A0.17206106
82CHEK10.16407840
83TEC0.16350628
84MAP2K60.15941347
85PRKCE0.15873943
86MAPK140.15106156
87PRKCB0.14854204
88PRKAA10.13549327
89PRKACB0.13240851
90AKT10.13071010
91DAPK20.12785463
92FER0.12410727
93MAP3K90.11400640
94FGFR20.11037377
95MAP3K10.10475794
96PLK10.10448119
97TESK20.09796415
98GRK10.09774763
99AURKA0.09527477
100OBSCN0.09303950

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.55851028
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.82523954
3Olfactory transduction_Homo sapiens_hsa047404.13794657
4Butanoate metabolism_Homo sapiens_hsa006502.62186038
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.29982013
6RNA transport_Homo sapiens_hsa030132.18971100
7Dorso-ventral axis formation_Homo sapiens_hsa043202.00530832
8Taste transduction_Homo sapiens_hsa047421.98865129
9Type I diabetes mellitus_Homo sapiens_hsa049401.91049861
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.86426270
11Fatty acid degradation_Homo sapiens_hsa000711.82212225
12Fatty acid metabolism_Homo sapiens_hsa012121.80787387
13Type II diabetes mellitus_Homo sapiens_hsa049301.58785490
14Phototransduction_Homo sapiens_hsa047441.56778474
15Cardiac muscle contraction_Homo sapiens_hsa042601.51029929
16Antigen processing and presentation_Homo sapiens_hsa046121.46517130
17Phenylalanine metabolism_Homo sapiens_hsa003601.46180347
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35256195
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33694087
20Autoimmune thyroid disease_Homo sapiens_hsa053201.32035700
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.25712516
22Allograft rejection_Homo sapiens_hsa053301.25481749
23Graft-versus-host disease_Homo sapiens_hsa053321.18235544
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17473795
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.14204144
26Insulin secretion_Homo sapiens_hsa049111.13210682
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11535585
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11255515
29ABC transporters_Homo sapiens_hsa020101.10426174
30Nicotine addiction_Homo sapiens_hsa050331.09103766
31Retinol metabolism_Homo sapiens_hsa008301.06744103
32Inositol phosphate metabolism_Homo sapiens_hsa005621.06322458
33Fat digestion and absorption_Homo sapiens_hsa049751.05982804
34Protein digestion and absorption_Homo sapiens_hsa049741.05576694
35Salivary secretion_Homo sapiens_hsa049701.04030110
36Glutamatergic synapse_Homo sapiens_hsa047240.99978461
37Morphine addiction_Homo sapiens_hsa050320.98404967
38Pancreatic secretion_Homo sapiens_hsa049720.96159168
39cAMP signaling pathway_Homo sapiens_hsa040240.94497904
40Calcium signaling pathway_Homo sapiens_hsa040200.90289125
41Nitrogen metabolism_Homo sapiens_hsa009100.89349156
42Linoleic acid metabolism_Homo sapiens_hsa005910.88367128
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87840599
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86609498
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85880835
46Synaptic vesicle cycle_Homo sapiens_hsa047210.85314263
47Renin secretion_Homo sapiens_hsa049240.81119625
48Serotonergic synapse_Homo sapiens_hsa047260.80291747
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79599713
50Viral myocarditis_Homo sapiens_hsa054160.78346420
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77603556
52Circadian entrainment_Homo sapiens_hsa047130.76671720
53PPAR signaling pathway_Homo sapiens_hsa033200.75510370
54Arginine and proline metabolism_Homo sapiens_hsa003300.73482373
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73208141
56Arginine biosynthesis_Homo sapiens_hsa002200.70066203
57Glycerolipid metabolism_Homo sapiens_hsa005610.69503051
58Oocyte meiosis_Homo sapiens_hsa041140.68173211
59Influenza A_Homo sapiens_hsa051640.66878988
60Tyrosine metabolism_Homo sapiens_hsa003500.65243172
61Huntingtons disease_Homo sapiens_hsa050160.65203127
62Fanconi anemia pathway_Homo sapiens_hsa034600.63702265
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62695420
64Bile secretion_Homo sapiens_hsa049760.62459323
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60782907
66Endocytosis_Homo sapiens_hsa041440.59543164
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59494736
68Renin-angiotensin system_Homo sapiens_hsa046140.58437998
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.55254071
70Vitamin B6 metabolism_Homo sapiens_hsa007500.53221380
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52239126
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49743467
73Amphetamine addiction_Homo sapiens_hsa050310.49460232
74Purine metabolism_Homo sapiens_hsa002300.49080222
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48556693
76Tryptophan metabolism_Homo sapiens_hsa003800.48209777
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46828665
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46722810
79GABAergic synapse_Homo sapiens_hsa047270.46452371
80Circadian rhythm_Homo sapiens_hsa047100.42150562
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.42136896
82Gastric acid secretion_Homo sapiens_hsa049710.40531121
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39214339
84mRNA surveillance pathway_Homo sapiens_hsa030150.38616279
85Regulation of autophagy_Homo sapiens_hsa041400.37953053
86Chemical carcinogenesis_Homo sapiens_hsa052040.33801931
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32446476
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32356272
89Hedgehog signaling pathway_Homo sapiens_hsa043400.29992101
90Mineral absorption_Homo sapiens_hsa049780.29459035
91Cholinergic synapse_Homo sapiens_hsa047250.28494985
92VEGF signaling pathway_Homo sapiens_hsa043700.27799540
93Oxytocin signaling pathway_Homo sapiens_hsa049210.27329317
94Long-term potentiation_Homo sapiens_hsa047200.26977990
95MAPK signaling pathway_Homo sapiens_hsa040100.26778326
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25098875
97Metabolic pathways_Homo sapiens_hsa011000.25080521
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.25062152
99Basal transcription factors_Homo sapiens_hsa030220.22901648
100Sulfur metabolism_Homo sapiens_hsa009200.21894252

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