ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.71485857
2	rRNA methylation (GO:0031167)	4.64622201
3	establishment of protein localization to Golgi (GO:0072600)	4.55204183
4	protein targeting to Golgi (GO:0000042)	4.53806348
5	fucose catabolic process (GO:0019317)	4.20347615
6	L-fucose metabolic process (GO:0042354)	4.20347615
7	L-fucose catabolic process (GO:0042355)	4.20347615
8	rRNA modification (GO:0000154)	4.07709225
9	cellular ketone body metabolic process (GO:0046950)	3.97585160
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.89608180
11	intra-S DNA damage checkpoint (GO:0031573)	3.89478135
12	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.89218489
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.89218489
14	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.88660580
15	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.83019186
16	protein localization to Golgi apparatus (GO:0034067)	3.55699404
17	DNA double-strand break processing (GO:0000729)	3.53185714
18	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.50241779
19	lactate metabolic process (GO:0006089)	3.48087898
20	ketone body metabolic process (GO:1902224)	3.47257961
21	regulation of protein glycosylation (GO:0060049)	3.46136712
22	folic acid-containing compound biosynthetic process (GO:0009396)	3.40152520
23	protein prenylation (GO:0018342)	3.38239255
24	prenylation (GO:0097354)	3.38239255
25	chaperone-mediated protein transport (GO:0072321)	3.35567095
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34915823
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.29826842
28	maturation of 5.8S rRNA (GO:0000460)	3.23228634
29	peptidyl-histidine modification (GO:0018202)	3.20385518
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.20379879
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.19385663
32	ribosome assembly (GO:0042255)	3.10429101
33	protein neddylation (GO:0045116)	3.09933007
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.08280808
35	sperm motility (GO:0030317)	3.07823032
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04910680
37	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.03936777
38	protein-cofactor linkage (GO:0018065)	3.03178731
39	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.00198519
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99114980
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99114980
42	NADH dehydrogenase complex assembly (GO:0010257)	2.99114980
43	piRNA metabolic process (GO:0034587)	2.98308389
44	pteridine-containing compound biosynthetic process (GO:0042559)	2.95932962
45	protein deneddylation (GO:0000338)	2.93437202
46	indolalkylamine metabolic process (GO:0006586)	2.93296253
47	branched-chain amino acid catabolic process (GO:0009083)	2.91000988
48	glycerol ether metabolic process (GO:0006662)	2.90656620
49	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.90230118
50	regulation of mitotic spindle checkpoint (GO:1903504)	2.90230118
51	S-adenosylmethionine metabolic process (GO:0046500)	2.89174873
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.88257227
53	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.87617940
54	protein complex biogenesis (GO:0070271)	2.87227686
55	ether lipid metabolic process (GO:0046485)	2.85520063
56	axoneme assembly (GO:0035082)	2.84533958
57	rRNA catabolic process (GO:0016075)	2.82848962
58	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.81429139
59	inositol phosphate dephosphorylation (GO:0046855)	2.81429139
60	signal peptide processing (GO:0006465)	2.80645885
61	tryptophan metabolic process (GO:0006568)	2.79946929
62	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.75701140
63	ether metabolic process (GO:0018904)	2.75626676
64	regulation of T cell receptor signaling pathway (GO:0050856)	2.75359452
65	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75009223
66	N-acetylglucosamine metabolic process (GO:0006044)	2.74012607
67	mannosylation (GO:0097502)	2.71573063
68	magnesium ion transport (GO:0015693)	2.71069167
69	protein localization to cilium (GO:0061512)	2.70717625
70	respiratory chain complex IV assembly (GO:0008535)	2.69752543
71	single strand break repair (GO:0000012)	2.69155124
72	synapsis (GO:0007129)	2.68650743
73	secondary heart field specification (GO:0003139)	2.68574426
74	heart field specification (GO:0003128)	2.68574426
75	leukotriene biosynthetic process (GO:0019370)	2.66768556
76	mast cell degranulation (GO:0043303)	2.65262618
77	mast cell activation involved in immune response (GO:0002279)	2.65262618
78	DNA catabolic process, exonucleolytic (GO:0000738)	2.64420228
79	regulation of memory T cell differentiation (GO:0043380)	2.64168965
80	mast cell activation (GO:0045576)	2.59198362
81	tRNA processing (GO:0008033)	2.57746518
82	epithelial cilium movement (GO:0003351)	2.56445947
83	inositol phosphate catabolic process (GO:0071545)	2.54961903
84	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.54477897
85	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.54477897
86	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.53731131
87	positive regulation of protein homodimerization activity (GO:0090073)	2.53684899
88	parturition (GO:0007567)	2.53567485
89	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.52615250
90	mismatch repair (GO:0006298)	2.50929033
91	male meiosis (GO:0007140)	2.48421330
92	intraciliary transport (GO:0042073)	2.46578896
93	cullin deneddylation (GO:0010388)	2.45874006
94	lateral ventricle development (GO:0021670)	2.43167614
95	N-terminal protein amino acid acetylation (GO:0006474)	2.43128568
96	intracellular protein transmembrane import (GO:0044743)	2.42796315
97	motile cilium assembly (GO:0044458)	2.42600329
98	IMP biosynthetic process (GO:0006188)	2.39968664
99	rRNA transcription (GO:0009303)	2.35870773
100	recombinational repair (GO:0000725)	2.35788259

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.39136038
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.86404815
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29185289
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.25773131
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18865076
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98840069
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.47432330
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47233737
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41937562
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.32937682
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.11161921
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11074902
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.08328853
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08202264
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07670549
16	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.04831754
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.00815153
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88781156
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80437564
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73938205
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71054591
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69708039
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66375486
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65749802
25	GATA3_26560356_Chip-Seq_TH2_Human	1.62405290
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60727811
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.58954727
28	P300_19829295_ChIP-Seq_ESCs_Human	1.58556705
29	CDX2_22108803_ChIP-Seq_LS180_Human	1.57395911
30	EWS_26573619_Chip-Seq_HEK293_Human	1.56322023
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52592247
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52592247
33	VDR_22108803_ChIP-Seq_LS180_Human	1.51824048
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50994119
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.50994119
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50810799
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48909640
38	FUS_26573619_Chip-Seq_HEK293_Human	1.47657876
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.47652888
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.46970773
41	AR_20517297_ChIP-Seq_VCAP_Human	1.46054358
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.42494069
43	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.41993087
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41244410
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.37010680
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.34207931
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33616481
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31638185
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29995804
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29995804
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28970704
52	MYB_26560356_Chip-Seq_TH2_Human	1.28493892
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28136611
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27046693
55	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26813535
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.24961637
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.24209516
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21315766
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21299200
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21091393
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20191151
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19164424
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19030445
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17259571
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17061120
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15690591
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.14414340
68	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14283481
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.14036403
70	ELF5_23300383_ChIP-Seq_T47D_Human	1.13006377
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12571323
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11125679
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10837516
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.10360873
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09458323
76	TAF15_26573619_Chip-Seq_HEK293_Human	1.08951247
77	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.07449951
78	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.07213678
79	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.05344334
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05253409
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.04954325
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04758537
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04624369
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04449156
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04071128
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02964393
87	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02785419
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02645737
89	GBX2_23144817_ChIP-Seq_PC3_Human	1.02180641
90	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01281233
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01234636
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01234636
93	GATA3_26560356_Chip-Seq_TH1_Human	1.00547312
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99314511
95	CBP_21632823_ChIP-Seq_H3396_Human	0.99084675
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97834075
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.97741207
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97524908
99	IGF1R_20145208_ChIP-Seq_DFB_Human	0.97462695
100	GATA3_27048872_Chip-Seq_THYMUS_Human	0.96299299

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.20107395
2	MP0003786_premature_aging	2.98928845
3	MP0002009_preneoplasia	2.93690883
4	MP0005379_endocrine/exocrine_gland_phen	2.91764988
5	MP0002837_dystrophic_cardiac_calcinosis	2.90606565
6	MP0002102_abnormal_ear_morphology	2.66268707
7	MP0008995_early_reproductive_senescence	2.39679247
8	MP0006072_abnormal_retinal_apoptosis	2.34899964
9	MP0005671_abnormal_response_to	2.34424375
10	MP0005084_abnormal_gallbladder_morpholo	2.10377249
11	MP0009780_abnormal_chondrocyte_physiolo	2.06717717
12	MP0002166_altered_tumor_susceptibility	2.05668529
13	MP0006054_spinal_hemorrhage	1.98057410
14	MP0008775_abnormal_heart_ventricle	1.97739269
15	MP0005410_abnormal_fertilization	1.93434642
16	MP0005365_abnormal_bile_salt	1.90172981
17	MP0008875_abnormal_xenobiotic_pharmacok	1.89452156
18	MP0002163_abnormal_gland_morphology	1.85216176
19	MP0002148_abnormal_hypersensitivity_rea	1.79076191
20	MP0005377_hearing/vestibular/ear_phenot	1.77757470
21	MP0003878_abnormal_ear_physiology	1.77757470
22	MP0002006_tumorigenesis	1.76072944
23	MP0003787_abnormal_imprinting	1.71142766
24	MP0001835_abnormal_antigen_presentation	1.64635133
25	MP0000427_abnormal_hair_cycle	1.62865707
26	MP0001986_abnormal_taste_sensitivity	1.62493326
27	MP0003763_abnormal_thymus_physiology	1.62223603
28	MP0001501_abnormal_sleep_pattern	1.60852994
29	MP0008872_abnormal_physiological_respon	1.57469355
30	MP0005253_abnormal_eye_physiology	1.48757239
31	MP0003806_abnormal_nucleotide_metabolis	1.45943096
32	MP0004215_abnormal_myocardial_fiber	1.42359801
33	MP0001800_abnormal_humoral_immune	1.40238951
34	MP0003436_decreased_susceptibility_to	1.38178644
35	MP0008058_abnormal_DNA_repair	1.36301772
36	MP0005551_abnormal_eye_electrophysiolog	1.34265940
37	MP0005000_abnormal_immune_tolerance	1.33309177
38	MP0004133_heterotaxia	1.29678181
39	MP0005646_abnormal_pituitary_gland	1.29371209
40	MP0002723_abnormal_immune_serum	1.28493228
41	MP0002653_abnormal_ependyma_morphology	1.25260038
42	MP0003195_calcinosis	1.25074704
43	MP0008961_abnormal_basal_metabolism	1.20698814
44	MP0002876_abnormal_thyroid_physiology	1.20135932
45	MP0005332_abnormal_amino_acid	1.18014828
46	MP0001984_abnormal_olfaction	1.16460780
47	MP0004742_abnormal_vestibular_system	1.15944486
48	MP0001765_abnormal_ion_homeostasis	1.15200260
49	MP0002452_abnormal_antigen_presenting	1.14084281
50	MP0006036_abnormal_mitochondrial_physio	1.13158472
51	MP0001819_abnormal_immune_cell	1.12481024
52	MP0002693_abnormal_pancreas_physiology	1.11111706
53	MP0002420_abnormal_adaptive_immunity	1.10404250
54	MP0009697_abnormal_copulation	1.10001379
55	MP0001929_abnormal_gametogenesis	1.09717078
56	MP0002933_joint_inflammation	1.09229503
57	MP0004142_abnormal_muscle_tone	1.07463556
58	MP0004147_increased_porphyrin_level	1.07451551
59	MP0002138_abnormal_hepatobiliary_system	1.05733094
60	MP0004782_abnormal_surfactant_physiolog	1.03867495
61	MP0004957_abnormal_blastocyst_morpholog	1.02821755
62	MP0003718_maternal_effect	1.01257020
63	MP0000230_abnormal_systemic_arterial	1.01054663
64	MP0005645_abnormal_hypothalamus_physiol	0.99028215
65	MP0009333_abnormal_splenocyte_physiolog	0.97708307
66	MP0003186_abnormal_redox_activity	0.97351608
67	MP0004484_altered_response_of	0.96719561
68	MP0008007_abnormal_cellular_replicative	0.95894104
69	MP0003879_abnormal_hair_cell	0.95780159
70	MP0004145_abnormal_muscle_electrophysio	0.93909884
71	MP0000613_abnormal_salivary_gland	0.93782751
72	MP0001666_abnormal_nutrient_absorption	0.92383835
73	MP0001944_abnormal_pancreas_morphology	0.92123296
74	MP0000647_abnormal_sebaceous_gland	0.90957873
75	MP0001845_abnormal_inflammatory_respons	0.89728351
76	MP0009764_decreased_sensitivity_to	0.89583206
77	MP0004885_abnormal_endolymph	0.89036512
78	MP0000631_abnormal_neuroendocrine_gland	0.86673866
79	MP0005165_increased_susceptibility_to	0.86610139
80	MP0010094_abnormal_chromosome_stability	0.85864978
81	MP0001485_abnormal_pinna_reflex	0.85680160
82	MP0000716_abnormal_immune_system	0.84741585
83	MP0003252_abnormal_bile_duct	0.84370044
84	MP0002398_abnormal_bone_marrow	0.83987616
85	MP0005167_abnormal_blood-brain_barrier	0.83104384
86	MP0010386_abnormal_urinary_bladder	0.82166420
87	MP0005636_abnormal_mineral_homeostasis	0.80568558
88	MP0001486_abnormal_startle_reflex	0.79799539
89	MP0001764_abnormal_homeostasis	0.79741384
90	MP0005389_reproductive_system_phenotype	0.79503678
91	MP0005367_renal/urinary_system_phenotyp	0.78707235
92	MP0000516_abnormal_urinary_system	0.78707235
93	MP0001968_abnormal_touch/_nociception	0.78282141
94	MP0005220_abnormal_exocrine_pancreas	0.77603880
95	MP0001873_stomach_inflammation	0.77324644
96	MP0000689_abnormal_spleen_morphology	0.77276223
97	MP0003698_abnormal_male_reproductive	0.77136447
98	MP0009643_abnormal_urine_homeostasis	0.76709063
99	MP0005085_abnormal_gallbladder_physiolo	0.76658270
100	MP0000653_abnormal_sex_gland	0.75285285

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.56186978
2	3-Methylglutaconic aciduria (HP:0003535)	3.68536076
3	Absent/shortened dynein arms (HP:0200106)	3.53805560
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.53805560
5	Nephronophthisis (HP:0000090)	3.16966828
6	Abnormality of alanine metabolism (HP:0010916)	3.16840651
7	Hyperalaninemia (HP:0003348)	3.16840651
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.16840651
9	Constricted visual fields (HP:0001133)	2.83409029
10	Colon cancer (HP:0003003)	2.82904945
11	Renal cortical cysts (HP:0000803)	2.81090258
12	Tongue fasciculations (HP:0001308)	2.72118010
13	Methylmalonic acidemia (HP:0002912)	2.68391707
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.66298758
15	Abnormality of the renal cortex (HP:0011035)	2.65961095
16	Pancreatic cysts (HP:0001737)	2.62211832
17	Hypoalbuminemia (HP:0003073)	2.56123432
18	Abnormal albumin level (HP:0012116)	2.56123432
19	Calf muscle hypertrophy (HP:0008981)	2.52793936
20	Metaphyseal dysplasia (HP:0100255)	2.51777554
21	Abnormality of midbrain morphology (HP:0002418)	2.51500307
22	Molar tooth sign on MRI (HP:0002419)	2.51500307
23	Abolished electroretinogram (ERG) (HP:0000550)	2.50415056
24	Abnormality of the renal medulla (HP:0100957)	2.50245571
25	IgG deficiency (HP:0004315)	2.49345504
26	Hypothermia (HP:0002045)	2.38103939
27	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.37109035
28	Thyroid-stimulating hormone excess (HP:0002925)	2.35421909
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34132990
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33656971
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33656971
32	Congenital, generalized hypertrichosis (HP:0004540)	2.30078315
33	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26567724
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.26567724
35	Abnormality of DNA repair (HP:0003254)	2.26186549
36	Abnormality of the pons (HP:0007361)	2.26163270
37	Abnormality of glycolysis (HP:0004366)	2.25095671
38	Muscle fibrillation (HP:0010546)	2.24694456
39	Abnormality of B cell number (HP:0010975)	2.23921767
40	Pancreatic fibrosis (HP:0100732)	2.23359372
41	Congenital stationary night blindness (HP:0007642)	2.23208832
42	Medial flaring of the eyebrow (HP:0010747)	2.21630050
43	Methylmalonic aciduria (HP:0012120)	2.21234049
44	Stomatitis (HP:0010280)	2.20922962
45	Muscle hypertrophy of the lower extremities (HP:0008968)	2.16033578
46	Abnormality of vitamin B metabolism (HP:0004340)	2.13523798
47	Stomach cancer (HP:0012126)	2.13465554
48	Increased CSF lactate (HP:0002490)	2.12854072
49	True hermaphroditism (HP:0010459)	2.12564409
50	Mitochondrial inheritance (HP:0001427)	2.07824871
51	Increased corneal curvature (HP:0100692)	2.07626634
52	Keratoconus (HP:0000563)	2.07626634
53	Acute necrotizing encephalopathy (HP:0006965)	2.07280211
54	Abnormality of T cell number (HP:0011839)	2.06292866
55	Hypoplasia of the pons (HP:0012110)	2.05056556
56	Abnormality of the prostate (HP:0008775)	2.04400325
57	Glycosuria (HP:0003076)	2.04125822
58	Abnormality of urine glucose concentration (HP:0011016)	2.04125822
59	Hypoproteinemia (HP:0003075)	2.02625242
60	Ketoacidosis (HP:0001993)	2.00495922
61	Lissencephaly (HP:0001339)	1.99600011
62	Increased serum pyruvate (HP:0003542)	1.98617227
63	Attenuation of retinal blood vessels (HP:0007843)	1.98247064
64	Abnormal ciliary motility (HP:0012262)	1.98057118
65	Cerebellar dysplasia (HP:0007033)	1.97699044
66	Renal Fanconi syndrome (HP:0001994)	1.96325350
67	T lymphocytopenia (HP:0005403)	1.96061813
68	Acute encephalopathy (HP:0006846)	1.94674581
69	Elevated erythrocyte sedimentation rate (HP:0003565)	1.92615904
70	Palpitations (HP:0001962)	1.91407242
71	Increased serum lactate (HP:0002151)	1.91135102
72	Ketosis (HP:0001946)	1.90399396
73	Abnormality of methionine metabolism (HP:0010901)	1.89492235
74	Increased hepatocellular lipid droplets (HP:0006565)	1.87788150
75	Polydipsia (HP:0001959)	1.87559967
76	Abnormal drinking behavior (HP:0030082)	1.87559967
77	Pendular nystagmus (HP:0012043)	1.86032147
78	Hyperglycinuria (HP:0003108)	1.85248992
79	Recurrent sinusitis (HP:0011108)	1.84606749
80	Progressive macrocephaly (HP:0004481)	1.83073995
81	B lymphocytopenia (HP:0010976)	1.83036060
82	Chronic bronchitis (HP:0004469)	1.82023896
83	Prostate neoplasm (HP:0100787)	1.81462265
84	Hepatic necrosis (HP:0002605)	1.81011317
85	Abnormality of serum amino acid levels (HP:0003112)	1.80612980
86	Double outlet right ventricle (HP:0001719)	1.80392440
87	Congenital malformation of the right heart (HP:0011723)	1.80392440
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.79420879
89	Abnormality of glycine metabolism (HP:0010895)	1.79420879
90	Fair hair (HP:0002286)	1.78407969
91	Abnormal rod and cone electroretinograms (HP:0008323)	1.78291680
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77658858
93	Abnormality of T cell physiology (HP:0011840)	1.77200875
94	Vasculitis (HP:0002633)	1.76995088
95	Thyroiditis (HP:0100646)	1.75710717
96	Hypoplasia of the uterus (HP:0000013)	1.75123385
97	Hematochezia (HP:0002573)	1.74260082
98	Rhinitis (HP:0012384)	1.74236552
99	Decreased central vision (HP:0007663)	1.73703210
100	Potter facies (HP:0002009)	1.73676021

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.99657159
2	CDK19	3.83722870
3	MST4	3.34089779
4	FRK	3.33431276
5	WNK3	2.77241084
6	WNK4	2.67111182
7	OXSR1	2.43550416
8	TEC	2.32841697
9	STK39	2.28586067
10	ERBB3	2.07303709
11	BMPR2	2.07238341
12	TLK1	2.05036977
13	TXK	2.04647450
14	EIF2AK3	2.02916517
15	ADRBK2	1.98726150
16	NUAK1	1.77074108
17	ZAK	1.67623132
18	PLK4	1.65324331
19	SIK3	1.60199970
20	ITK	1.54207380
21	MKNK2	1.53968320
22	GRK1	1.49870851
23	BUB1	1.48814506
24	PHKG2	1.48643988
25	PHKG1	1.48643988
26	MAP2K6	1.39124823
27	MAP4K1	1.35167028
28	SCYL2	1.31909801
29	STK16	1.27380026
30	TAF1	1.27072377
31	PLK2	1.25358339
32	VRK2	1.23509451
33	INSRR	1.23107760
34	PIK3CG	1.23079563
35	BTK	1.20577592
36	MAP3K4	1.19168231
37	EIF2AK2	1.17676152
38	MAP2K2	1.16035943
39	MKNK1	1.13720893
40	VRK1	1.11854554
41	ACVR1B	1.08755782
42	MAP4K2	1.07828331
43	PLK3	1.04820924
44	STK3	1.04214964
45	PINK1	1.02334468
46	IRAK4	1.00962089
47	MAP2K7	1.00555089
48	MAP3K2	1.00014253
49	PAK3	0.96900759
50	TRIM28	0.95717365
51	GRK6	0.95568939
52	CSF1R	0.94522988
53	ALK	0.94480449
54	NEK1	0.94128861
55	BRSK2	0.93284364
56	STK10	0.83300595
57	BMPR1B	0.82027560
58	RPS6KA4	0.77183111
59	TSSK6	0.72841277
60	RIPK4	0.69452686
61	TIE1	0.69186864
62	RPS6KA5	0.68632891
63	TNIK	0.66475118
64	IKBKE	0.65766196
65	PRKCQ	0.65427569
66	SRPK1	0.65163238
67	TRPM7	0.63026322
68	BCR	0.60945854
69	MAP3K12	0.60600390
70	KIT	0.58244160
71	TNK2	0.54950963
72	IKBKB	0.54057111
73	TBK1	0.54011472
74	SYK	0.53669534
75	CLK1	0.53422400
76	PIK3CA	0.52362107
77	ADRBK1	0.51629591
78	PRKCE	0.49908275
79	ATR	0.48952709
80	CDK3	0.47602092
81	MAP3K14	0.47577406
82	LCK	0.45204785
83	FER	0.44846820
84	DAPK2	0.44668037
85	CAMK2D	0.43175767
86	IGF1R	0.40883155
87	PASK	0.40233725
88	ABL1	0.39693540
89	JAK1	0.36160416
90	PTK2B	0.35018369
91	CSNK1G3	0.34744692
92	MAP2K1	0.33474828
93	TYK2	0.32306291
94	CDC7	0.32159941
95	RAF1	0.30331756
96	KSR1	0.29772771
97	HCK	0.29684716
98	CAMKK2	0.29673788
99	OBSCN	0.29328117
100	FES	0.28867234

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.74194020
2	One carbon pool by folate_Homo sapiens_hsa00670	2.72357780
3	Proteasome_Homo sapiens_hsa03050	2.55005135
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53640098
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38606517
6	RNA degradation_Homo sapiens_hsa03018	2.30214989
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10341873
8	RNA polymerase_Homo sapiens_hsa03020	2.07362076
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.02647268
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.98548194
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97728763
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95653074
13	Phototransduction_Homo sapiens_hsa04744	1.94499977
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89714759
15	Homologous recombination_Homo sapiens_hsa03440	1.85283506
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.84815016
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.82755503
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.82002042
19	Sulfur metabolism_Homo sapiens_hsa00920	1.80413798
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78846842
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.72718256
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71555151
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64247714
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.63211109
25	Propanoate metabolism_Homo sapiens_hsa00640	1.61983545
26	Asthma_Homo sapiens_hsa05310	1.49328553
27	Butanoate metabolism_Homo sapiens_hsa00650	1.48407855
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.47073697
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46442631
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.46290709
31	Parkinsons disease_Homo sapiens_hsa05012	1.44482584
32	Peroxisome_Homo sapiens_hsa04146	1.37007894
33	RNA transport_Homo sapiens_hsa03013	1.28053750
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.27544872
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18655195
36	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16122795
37	Regulation of autophagy_Homo sapiens_hsa04140	1.16000292
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.11740791
39	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.10660872
40	Allograft rejection_Homo sapiens_hsa05330	1.09980841
41	Basal transcription factors_Homo sapiens_hsa03022	1.07385372
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.06214713
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05045134
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01022790
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00742336
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97452224
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96672518
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94116327
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.92785913
50	Purine metabolism_Homo sapiens_hsa00230	0.90521754
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88722155
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85647300
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85559506
54	Olfactory transduction_Homo sapiens_hsa04740	0.85083539
55	Huntingtons disease_Homo sapiens_hsa05016	0.84056748
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83667332
57	Alzheimers disease_Homo sapiens_hsa05010	0.83569141
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.81592446
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.81069596
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79826459
61	Spliceosome_Homo sapiens_hsa03040	0.77844807
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76951791
63	Retinol metabolism_Homo sapiens_hsa00830	0.75859848
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75776173
65	p53 signaling pathway_Homo sapiens_hsa04115	0.74886671
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74777318
67	Metabolic pathways_Homo sapiens_hsa01100	0.73507587
68	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70696614
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.69962989
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69085475
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68633201
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67550109
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66140393
74	Folate biosynthesis_Homo sapiens_hsa00790	0.65257869
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62274028
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60728613
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59951026
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.59792685
79	Caffeine metabolism_Homo sapiens_hsa00232	0.59511724
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58597747
81	Fatty acid degradation_Homo sapiens_hsa00071	0.58351642
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53253087
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51893428
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51514529
85	Glutathione metabolism_Homo sapiens_hsa00480	0.48467990
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48110135
87	Salivary secretion_Homo sapiens_hsa04970	0.45358478
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45110315
89	Mismatch repair_Homo sapiens_hsa03430	0.44453339
90	Serotonergic synapse_Homo sapiens_hsa04726	0.44409081
91	Legionellosis_Homo sapiens_hsa05134	0.42373552
92	Circadian rhythm_Homo sapiens_hsa04710	0.41498224
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.40923397
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39836317
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39102803
96	Circadian entrainment_Homo sapiens_hsa04713	0.38024405
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36849177
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36727323
99	Renin secretion_Homo sapiens_hsa04924	0.35549674
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34278167

CTAGE11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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