ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	9.95534654
2	chromosome organization involved in meiosis (GO:0070192)	7.61684656
3	homocysteine metabolic process (GO:0050667)	7.31594863
4	synaptonemal complex assembly (GO:0007130)	7.13067180
5	piRNA metabolic process (GO:0034587)	7.02427117
6	male meiosis I (GO:0007141)	7.01211862
7	male meiosis (GO:0007140)	6.63891531
8	synaptonemal complex organization (GO:0070193)	6.51061095
9	DNA methylation involved in gamete generation (GO:0043046)	6.41615556
10	negative regulation of Ras GTPase activity (GO:0034261)	6.00753044
11	cysteine metabolic process (GO:0006534)	5.60932053
12	meiosis I (GO:0007127)	5.47574116
13	DNA synthesis involved in DNA repair (GO:0000731)	5.37433956
14	regulation of plasminogen activation (GO:0010755)	5.02177432
15	sulfur amino acid catabolic process (GO:0000098)	4.95111638
16	meiotic nuclear division (GO:0007126)	4.86730065
17	negative regulation of catenin import into nucleus (GO:0035414)	4.85316971
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.84082626
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.84082626
20	microtubule nucleation (GO:0007020)	4.79210077
21	regulation of G0 to G1 transition (GO:0070316)	4.48374805
22	behavioral response to nicotine (GO:0035095)	4.45335599
23	positive regulation of oligodendrocyte differentiation (GO:0048714)	4.43530620
24	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.42919451
25	reciprocal meiotic recombination (GO:0007131)	4.20527878
26	reciprocal DNA recombination (GO:0035825)	4.20527878
27	positive regulation of synapse maturation (GO:0090129)	4.13184857
28	meiotic cell cycle process (GO:1903046)	4.09018975
29	folic acid-containing compound biosynthetic process (GO:0009396)	4.06792580
30	regulation of sequestering of triglyceride (GO:0010889)	3.93794060
31	protein targeting to vacuole (GO:0006623)	3.91351113
32	protein targeting to lysosome (GO:0006622)	3.91351113
33	establishment of protein localization to vacuole (GO:0072666)	3.91351113
34	negative regulation of inclusion body assembly (GO:0090084)	3.91347096
35	negative regulation of DNA biosynthetic process (GO:2000279)	3.89770408
36	regulation of synapse maturation (GO:0090128)	3.84555175
37	positive regulation of meiosis (GO:0045836)	3.84116183
38	cell migration involved in heart development (GO:0060973)	3.83736494
39	cochlea development (GO:0090102)	3.75154685
40	inner ear receptor cell development (GO:0060119)	3.70304016
41	resolution of meiotic recombination intermediates (GO:0000712)	3.69766334
42	white fat cell differentiation (GO:0050872)	3.59234116
43	positive regulation of meiotic cell cycle (GO:0051446)	3.54133200
44	sister chromatid cohesion (GO:0007062)	3.48592628
45	retinal cone cell development (GO:0046549)	3.48314859
46	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.46265232
47	DNA alkylation (GO:0006305)	3.43792900
48	DNA methylation (GO:0006306)	3.43792900
49	phosphatidylglycerol biosynthetic process (GO:0006655)	3.43582357
50	response to lipoprotein particle (GO:0055094)	3.34616468
51	indolalkylamine catabolic process (GO:0046218)	3.34306497
52	tryptophan catabolic process (GO:0006569)	3.34306497
53	indole-containing compound catabolic process (GO:0042436)	3.34306497
54	vascular smooth muscle contraction (GO:0014829)	3.30402354
55	cartilage morphogenesis (GO:0060536)	3.24173106
56	histone H4-K12 acetylation (GO:0043983)	3.24131048
57	acrosome assembly (GO:0001675)	3.23215055
58	single strand break repair (GO:0000012)	3.19771402
59	spinal cord association neuron differentiation (GO:0021527)	3.16533916
60	kynurenine metabolic process (GO:0070189)	3.06620244
61	adenosine metabolic process (GO:0046085)	3.06417561
62	positive regulation of endothelial cell differentiation (GO:0045603)	3.05827288
63	artery smooth muscle contraction (GO:0014824)	3.05063462
64	regulation of meiotic cell cycle (GO:0051445)	3.04867379
65	sulfur amino acid biosynthetic process (GO:0000097)	3.03541840
66	gamma-aminobutyric acid transport (GO:0015812)	3.02836296
67	neuronal stem cell maintenance (GO:0097150)	3.01765981
68	reproductive system development (GO:0061458)	3.00827409
69	regulation of meiosis I (GO:0060631)	2.99649022
70	pancreas development (GO:0031016)	2.98109199
71	tryptophan metabolic process (GO:0006568)	2.96529017
72	negative regulation of telomerase activity (GO:0051974)	2.95850397
73	desmosome organization (GO:0002934)	2.93233309
74	regulation of vitamin D biosynthetic process (GO:0060556)	2.93143428
75	heme transport (GO:0015886)	2.93052877
76	histone exchange (GO:0043486)	2.88359626
77	purine nucleotide salvage (GO:0032261)	2.83035415
78	S-adenosylmethionine metabolic process (GO:0046500)	2.82356054
79	neuron fate specification (GO:0048665)	2.81535481
80	DNA methylation or demethylation (GO:0044728)	2.80742436
81	histone H2A acetylation (GO:0043968)	2.80692520
82	membrane repolarization (GO:0086009)	2.79867420
83	innervation (GO:0060384)	2.76502765
84	regulation of sarcomere organization (GO:0060297)	2.75383415
85	regulation of oligodendrocyte differentiation (GO:0048713)	2.74322971
86	serine family amino acid catabolic process (GO:0009071)	2.72763251
87	gene silencing by RNA (GO:0031047)	2.71912409
88	indolalkylamine metabolic process (GO:0006586)	2.70992409
89	axonemal dynein complex assembly (GO:0070286)	2.68636706
90	sulfation (GO:0051923)	2.67914940
91	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.67895685
92	positive regulation of Notch signaling pathway (GO:0045747)	2.64509267
93	histone H3-K9 demethylation (GO:0033169)	2.62855408
94	primary amino compound metabolic process (GO:1901160)	2.62366537
95	histone H3-K9 methylation (GO:0051567)	2.59268572
96	regulation of endothelial cell differentiation (GO:0045601)	2.57937518
97	protein localization to vacuole (GO:0072665)	2.57452024
98	protein localization to lysosome (GO:0061462)	2.57452024
99	forebrain neuron differentiation (GO:0021879)	2.57437254
100	energy homeostasis (GO:0097009)	2.54583345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.14801852
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.78296905
3	BMI1_23680149_ChIP-Seq_NPCS_Mouse	3.01074768
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90961147
5	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.74231378
6	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.72797608
7	RNF2_27304074_Chip-Seq_NSC_Mouse	2.68870988
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64210925
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.50883419
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.45311929
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.45140874
12	BCAT_22108803_ChIP-Seq_LS180_Human	2.38206689
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35634606
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.33905653
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31359392
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05822474
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.04613122
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98703753
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.95594801
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.92389901
21	FUS_26573619_Chip-Seq_HEK293_Human	1.91345557
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.90584463
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89103425
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.85932283
25	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.84908793
26	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.76002942
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.74860219
28	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.74860219
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72772499
30	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.72374293
31	P300_19829295_ChIP-Seq_ESCs_Human	1.72207899
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.70617820
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66733324
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.65840597
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.61447660
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.57792574
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57474917
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.54309535
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53546368
40	RUNX2_22187159_ChIP-Seq_PCA_Human	1.52131899
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50483552
42	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.50397451
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.48438518
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.48155233
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46891704
46	EWS_26573619_Chip-Seq_HEK293_Human	1.44790300
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44318540
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.43966434
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41395751
50	AR_25329375_ChIP-Seq_VCAP_Human	1.36338079
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36025043
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.32783494
53	RXR_22108803_ChIP-Seq_LS180_Human	1.31528454
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30466053
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.29189019
56	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26373623
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26029481
58	STAT3_23295773_ChIP-Seq_U87_Human	1.24571157
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23710847
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.23104989
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22584131
62	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.21588874
63	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.20423469
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18170535
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15982351
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14559958
67	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14382341
68	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14109129
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13592303
70	TCF4_23295773_ChIP-Seq_U87_Human	1.12476116
71	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09540033
72	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.09227827
73	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.06984183
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04247132
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02662314
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.02662314
77	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.02190967
78	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00930990
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00810113
80	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00805371
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99018483
82	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99018483
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98156898
84	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.98023001
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97026754
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96978285
87	NCOR_22424771_ChIP-Seq_293T_Human	0.96805541
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96475289
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96425128
90	TBL1_22424771_ChIP-Seq_293T_Human	0.94609479
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94335201
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94157892
93	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93160749
94	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.91839785
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90685616
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90495797
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.90069824
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89957575
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89115932
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87785559

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.02380572
2	MP0008877_abnormal_DNA_methylation	3.77901173
3	MP0008995_early_reproductive_senescence	3.54646618
4	MP0002735_abnormal_chemical_nociception	3.33078327
5	MP0002653_abnormal_ependyma_morphology	3.00800297
6	MP0002736_abnormal_nociception_after	2.77580901
7	MP0003183_abnormal_peptide_metabolism	2.53490027
8	MP0005646_abnormal_pituitary_gland	2.42443413
9	MP0004885_abnormal_endolymph	2.42007971
10	MP0002160_abnormal_reproductive_system	2.38535636
11	MP0006292_abnormal_olfactory_placode	2.33356661
12	MP0002210_abnormal_sex_determination	2.27901742
13	MP0001661_extended_life_span	2.26527454
14	MP0000516_abnormal_urinary_system	2.18710994
15	MP0005367_renal/urinary_system_phenotyp	2.18710994
16	MP0001968_abnormal_touch/_nociception	2.14451072
17	MP0005670_abnormal_white_adipose	2.11637967
18	MP0005360_urolithiasis	2.03364522
19	MP0005171_absent_coat_pigmentation	1.94152094
20	MP0009840_abnormal_foam_cell	1.91183673
21	MP0008789_abnormal_olfactory_epithelium	1.86142103
22	MP0000534_abnormal_ureter_morphology	1.82739979
23	MP0000778_abnormal_nervous_system	1.82086383
24	MP0003880_abnormal_central_pattern	1.73362504
25	MP0001145_abnormal_male_reproductive	1.70994043
26	MP0003698_abnormal_male_reproductive	1.70056658
27	MP0003890_abnormal_embryonic-extraembry	1.69415266
28	MP0002095_abnormal_skin_pigmentation	1.67016734
29	MP0000013_abnormal_adipose_tissue	1.66114107
30	MP0002184_abnormal_innervation	1.66017627
31	MP0001929_abnormal_gametogenesis	1.65017077
32	MP0009250_abnormal_appendicular_skeleto	1.62481610
33	MP0000653_abnormal_sex_gland	1.62087567
34	MP0009053_abnormal_anal_canal	1.60073211
35	MP0005389_reproductive_system_phenotype	1.46109309
36	MP0001486_abnormal_startle_reflex	1.43001554
37	MP0001440_abnormal_grooming_behavior	1.40273640
38	MP0000026_abnormal_inner_ear	1.39645216
39	MP0001299_abnormal_eye_distance/	1.39592787
40	MP0004043_abnormal_pH_regulation	1.38731644
41	MP0000955_abnormal_spinal_cord	1.35841714
42	MP0004147_increased_porphyrin_level	1.34769059
43	MP0000647_abnormal_sebaceous_gland	1.33394333
44	MP0005551_abnormal_eye_electrophysiolog	1.32029374
45	MP0002009_preneoplasia	1.30102887
46	MP0004133_heterotaxia	1.28378116
47	MP0000631_abnormal_neuroendocrine_gland	1.25245093
48	MP0005253_abnormal_eye_physiology	1.23375701
49	MP0001346_abnormal_lacrimal_gland	1.15122946
50	MP0002249_abnormal_larynx_morphology	1.12320748
51	MP0005499_abnormal_olfactory_system	1.11418152
52	MP0005394_taste/olfaction_phenotype	1.11418152
53	MP0001119_abnormal_female_reproductive	1.10371579
54	MP0005220_abnormal_exocrine_pancreas	1.09806439
55	MP0005195_abnormal_posterior_eye	1.08952551
56	MP0000049_abnormal_middle_ear	1.08290814
57	MP0003786_premature_aging	1.08072241
58	MP0002938_white_spotting	1.07749492
59	MP0009745_abnormal_behavioral_response	1.07480381
60	MP0001963_abnormal_hearing_physiology	1.06299263
61	MP0001502_abnormal_circadian_rhythm	1.06102769
62	MP0002752_abnormal_somatic_nervous	1.02707439
63	MP0005248_abnormal_Harderian_gland	1.00520208
64	MP0001188_hyperpigmentation	0.98517229
65	MP0000579_abnormal_nail_morphology	0.97977859
66	MP0004185_abnormal_adipocyte_glucose	0.97485940
67	MP0008058_abnormal_DNA_repair	0.95309818
68	MP0002067_abnormal_sensory_capabilities	0.91831827
69	MP0001501_abnormal_sleep_pattern	0.91271168
70	MP0005386_behavior/neurological_phenoty	0.89974603
71	MP0004924_abnormal_behavior	0.89974603
72	MP0001944_abnormal_pancreas_morphology	0.89768829
73	MP0002882_abnormal_neuron_morphology	0.86684142
74	MP0002102_abnormal_ear_morphology	0.85557946
75	MP0002063_abnormal_learning/memory/cond	0.84424420
76	MP0001286_abnormal_eye_development	0.84094937
77	MP0002229_neurodegeneration	0.83695240
78	MP0001485_abnormal_pinna_reflex	0.82422883
79	MP0003942_abnormal_urinary_system	0.82183561
80	MP0003119_abnormal_digestive_system	0.80908201
81	MP0004742_abnormal_vestibular_system	0.80479855
82	MP0006072_abnormal_retinal_apoptosis	0.80295786
83	MP0002272_abnormal_nervous_system	0.79668227
84	MP0010386_abnormal_urinary_bladder	0.78907788
85	MP0005423_abnormal_somatic_nervous	0.78876768
86	MP0003699_abnormal_female_reproductive	0.78279867
87	MP0000538_abnormal_urinary_bladder	0.78043049
88	MP0002572_abnormal_emotion/affect_behav	0.76128165
89	MP0002697_abnormal_eye_size	0.75976726
90	MP0006276_abnormal_autonomic_nervous	0.75695330
91	MP0001270_distended_abdomen	0.74850671
92	MP0002933_joint_inflammation	0.73951175
93	MP0008872_abnormal_physiological_respon	0.73430925
94	MP0000383_abnormal_hair_follicle	0.73238673
95	MP0002161_abnormal_fertility/fecundity	0.72113349
96	MP0004215_abnormal_myocardial_fiber	0.71661265
97	MP0003635_abnormal_synaptic_transmissio	0.70240910
98	MP0002233_abnormal_nose_morphology	0.69706767
99	MP0008057_abnormal_DNA_replication	0.69424332
100	MP0002734_abnormal_mechanical_nocicepti	0.68537932

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.00309987
2	Hyperalaninemia (HP:0003348)	7.00309987
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.00309987
4	Constricted visual fields (HP:0001133)	5.01493309
5	Action tremor (HP:0002345)	4.97125448
6	Oligodactyly (hands) (HP:0001180)	4.88583221
7	Congenital sensorineural hearing impairment (HP:0008527)	3.88107881
8	White forelock (HP:0002211)	3.87736442
9	Patchy hypopigmentation of hair (HP:0011365)	3.70007428
10	Maternal diabetes (HP:0009800)	3.59730754
11	Hypoalphalipoproteinemia (HP:0003233)	3.47724017
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.45337346
13	Progressive cerebellar ataxia (HP:0002073)	3.39256871
14	Oligodactyly (HP:0012165)	3.20862850
15	Postural tremor (HP:0002174)	3.15121421
16	Spontaneous hematomas (HP:0007420)	3.11344017
17	Decreased subcutaneous fat (HP:0001002)	3.10409721
18	Supernumerary spleens (HP:0009799)	3.04229697
19	Abnormality of DNA repair (HP:0003254)	2.97593455
20	Esophageal varix (HP:0002040)	2.82341206
21	Congenital, generalized hypertrichosis (HP:0004540)	2.76894523
22	Abnormal umbilical cord blood vessels (HP:0011403)	2.73316463
23	Single umbilical artery (HP:0001195)	2.73316463
24	Abnormality of the fetal cardiovascular system (HP:0010948)	2.73316463
25	Abnormality of the lower motor neuron (HP:0002366)	2.61868131
26	Poor speech (HP:0002465)	2.55888396
27	Abnormality of serum amino acid levels (HP:0003112)	2.54477423
28	Abnormality of homocysteine metabolism (HP:0010919)	2.53979944
29	Homocystinuria (HP:0002156)	2.53979944
30	Horizontal nystagmus (HP:0000666)	2.42521676
31	Conjunctival telangiectasia (HP:0000524)	2.40901460
32	Tubulointerstitial nephritis (HP:0001970)	2.36499335
33	Anencephaly (HP:0002323)	2.33503762
34	Ectopic kidney (HP:0000086)	2.32344821
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29766700
36	Heterochromia iridis (HP:0001100)	2.26806601
37	Hyperlipoproteinemia (HP:0010980)	2.24928621
38	Hyperglycinemia (HP:0002154)	2.24370651
39	Congenital stationary night blindness (HP:0007642)	2.23333947
40	Esophageal atresia (HP:0002032)	2.23198082
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.21982086
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21982086
43	Abnormality of subcutaneous fat tissue (HP:0001001)	2.19906163
44	Amyotrophic lateral sclerosis (HP:0007354)	2.15828133
45	Delayed CNS myelination (HP:0002188)	2.13561359
46	Occipital encephalocele (HP:0002085)	2.13313815
47	Chorioretinal atrophy (HP:0000533)	2.13147982
48	Brittle hair (HP:0002299)	2.09611713
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08582203
50	Attenuation of retinal blood vessels (HP:0007843)	2.05158229
51	Choroideremia (HP:0001139)	2.04197482
52	Visceral angiomatosis (HP:0100761)	2.04165324
53	Chronic hepatic failure (HP:0100626)	2.03555192
54	Short tibia (HP:0005736)	2.03547630
55	Abnormal lung lobation (HP:0002101)	2.01878464
56	Gastrointestinal atresia (HP:0002589)	1.99941913
57	Rib fusion (HP:0000902)	1.99584056
58	Hypoplastic iliac wings (HP:0002866)	1.99368122
59	Small hand (HP:0200055)	1.99156281
60	Chromsome breakage (HP:0040012)	1.98791707
61	Azoospermia (HP:0000027)	1.98201667
62	Epidermoid cyst (HP:0200040)	1.97904589
63	Septo-optic dysplasia (HP:0100842)	1.96310220
64	Birth length less than 3rd percentile (HP:0003561)	1.94283580
65	Optic nerve hypoplasia (HP:0000609)	1.92838862
66	Rimmed vacuoles (HP:0003805)	1.90978783
67	Hypopigmentation of the fundus (HP:0007894)	1.90692160
68	Hypolipoproteinemia (HP:0010981)	1.87959431
69	Abnormal pancreas size (HP:0012094)	1.86659694
70	Pulmonary embolism (HP:0002204)	1.86253293
71	Anorexia (HP:0002039)	1.85856834
72	Large eyes (HP:0001090)	1.85067569
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84215413
74	Chronic bronchitis (HP:0004469)	1.82606322
75	Hypoplastic labia majora (HP:0000059)	1.82380077
76	Duplication of thumb phalanx (HP:0009942)	1.79044412
77	Infertility (HP:0000789)	1.77945490
78	Shoulder girdle muscle weakness (HP:0003547)	1.77606751
79	Absent septum pellucidum (HP:0001331)	1.77142606
80	Hemangiomatosis (HP:0007461)	1.76348953
81	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.75052680
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73600070
83	Anophthalmia (HP:0000528)	1.72504276
84	Oligomenorrhea (HP:0000876)	1.72227487
85	Proximal tubulopathy (HP:0000114)	1.72117120
86	Arteriovenous malformation (HP:0100026)	1.71527628
87	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70574851
88	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70574851
89	Abnormality of the corticospinal tract (HP:0002492)	1.69960906
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69951478
91	Absent/shortened dynein arms (HP:0200106)	1.69951478
92	Spontaneous abortion (HP:0005268)	1.68885781
93	Type I diabetes mellitus (HP:0100651)	1.67552553
94	Anomalous pulmonary venous return (HP:0010772)	1.67337956
95	Aplasia involving forearm bones (HP:0009822)	1.65047781
96	Absent forearm bone (HP:0003953)	1.65047781
97	Impaired vibration sensation in the lower limbs (HP:0002166)	1.64713210
98	Concave nail (HP:0001598)	1.64546661
99	Short chin (HP:0000331)	1.64498926
100	Protruding tongue (HP:0010808)	1.62936014

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK1	5.72705158
2	ACVR1B	5.42939881
3	NTRK2	5.12083211
4	PNCK	5.00450519
5	CASK	3.27589504
6	MAPK15	2.53424329
7	TLK1	2.28594611
8	STK38L	2.18191603
9	BMPR1B	2.05188489
10	FGR	1.82072005
11	PINK1	1.79287479
12	CDK19	1.77352831
13	CCNB1	1.64334583
14	OXSR1	1.62098394
15	LMTK2	1.55287060
16	CDK9	1.51298828
17	MAP2K3	1.36699489
18	NTRK3	1.29488877
19	ADRBK1	1.26967041
20	MAP3K3	1.22944665
21	AKT3	1.22931419
22	RPS6KB2	1.22408792
23	JAK3	1.21887251
24	NEK6	1.17771254
25	GRK7	1.17144606
26	FRK	1.13693889
27	ADRBK2	1.13109274
28	TSSK6	1.08907830
29	SGK494	1.08664514
30	SGK223	1.08664514
31	ZAK	1.07558597
32	SGK2	1.05110135
33	STK39	1.04913473
34	MAP2K1	0.93245177
35	TXK	0.92189987
36	RPS6KB1	0.88774244
37	WEE1	0.88760991
38	MELK	0.87810375
39	VRK1	0.86581200
40	CSF1R	0.84802385
41	NUAK1	0.82725171
42	TIE1	0.82419334
43	LATS1	0.81220252
44	PDK2	0.81051047
45	EPHB2	0.80181308
46	OBSCN	0.77163716
47	CDK3	0.73132805
48	PHKG1	0.71786083
49	PHKG2	0.71786083
50	WNK4	0.68622803
51	MAP3K4	0.68568483
52	TTK	0.68162981
53	MAP4K2	0.67296840
54	MAP2K2	0.66599079
55	EPHA4	0.66419581
56	SGK1	0.61100653
57	NEK2	0.60171190
58	PTK2B	0.57438380
59	MAP3K5	0.57317624
60	WNK3	0.55819535
61	PRKD1	0.52288475
62	TYRO3	0.50385151
63	PRKCG	0.50013867
64	CAMK2A	0.49339603
65	PLK4	0.48314735
66	ATR	0.48039967
67	PIK3CA	0.47670498
68	TGFBR1	0.46944920
69	AURKA	0.46106125
70	DYRK1B	0.45943816
71	BRSK2	0.43762359
72	STK11	0.43295624
73	RET	0.42876267
74	PLK1	0.41617533
75	PRKCQ	0.40523200
76	CAMK1	0.40324951
77	PRKCI	0.40278605
78	MET	0.36282041
79	CSNK1A1	0.35899851
80	BRAF	0.35778996
81	MAP3K11	0.35734178
82	GRK1	0.35655906
83	MAPK13	0.35400154
84	INSR	0.34732202
85	PRKCE	0.33717092
86	CAMK2B	0.32059343
87	CAMK1G	0.30061466
88	INSRR	0.29715742
89	PLK2	0.29684402
90	BCKDK	0.28921372
91	STK3	0.28674605
92	TAOK3	0.28020965
93	DYRK1A	0.28010518
94	SGK3	0.26767995
95	CHEK2	0.26669431
96	EGFR	0.26626866
97	BRD4	0.26240602
98	ATM	0.25665351
99	BMX	0.25204550
100	MAP2K7	0.25107379

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.73785700
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.41442349
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.39513412
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.16614301
5	Nicotine addiction_Homo sapiens_hsa05033	2.99637397
6	Sulfur relay system_Homo sapiens_hsa04122	2.91293235
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.45210458
8	Morphine addiction_Homo sapiens_hsa05032	2.26479408
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.15286746
10	GABAergic synapse_Homo sapiens_hsa04727	2.12901432
11	Taste transduction_Homo sapiens_hsa04742	1.95609836
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.84996932
13	Caffeine metabolism_Homo sapiens_hsa00232	1.78893628
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78862287
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.75703816
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.73944277
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.66637131
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62569722
19	Sulfur metabolism_Homo sapiens_hsa00920	1.59600573
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59417428
21	Circadian entrainment_Homo sapiens_hsa04713	1.56907357
22	Circadian rhythm_Homo sapiens_hsa04710	1.56574168
23	Regulation of autophagy_Homo sapiens_hsa04140	1.47473051
24	ABC transporters_Homo sapiens_hsa02010	1.44074123
25	Serotonergic synapse_Homo sapiens_hsa04726	1.39123356
26	Basal transcription factors_Homo sapiens_hsa03022	1.30079342
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26275137
28	Retinol metabolism_Homo sapiens_hsa00830	1.24728880
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.22465694
30	Salivary secretion_Homo sapiens_hsa04970	1.22447910
31	Cholinergic synapse_Homo sapiens_hsa04725	1.21992154
32	Homologous recombination_Homo sapiens_hsa03440	1.18115452
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.17617634
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.15508333
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14965679
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.12919512
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07836582
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.06602644
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05929844
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04924085
41	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.00517442
42	Propanoate metabolism_Homo sapiens_hsa00640	0.92542773
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91293741
44	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.89903450
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89889230
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89494641
47	Alcoholism_Homo sapiens_hsa05034	0.85425786
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.84645899
49	Peroxisome_Homo sapiens_hsa04146	0.84258878
50	Axon guidance_Homo sapiens_hsa04360	0.83860828
51	Renin secretion_Homo sapiens_hsa04924	0.81956569
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.81560287
53	RNA degradation_Homo sapiens_hsa03018	0.79298659
54	Lysine degradation_Homo sapiens_hsa00310	0.75671416
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74950295
56	Olfactory transduction_Homo sapiens_hsa04740	0.71426786
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71375285
58	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69238737
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.68824732
60	Insulin secretion_Homo sapiens_hsa04911	0.67891039
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66818064
62	Proteasome_Homo sapiens_hsa03050	0.65911842
63	RNA transport_Homo sapiens_hsa03013	0.65350479
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.65044984
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63667853
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62011279
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.60442082
68	Phototransduction_Homo sapiens_hsa04744	0.60334313
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57280626
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.56479326
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56033061
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53330326
73	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.53270323
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.51092121
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.50224424
76	Oocyte meiosis_Homo sapiens_hsa04114	0.47677607
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46952518
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44924157
79	Amphetamine addiction_Homo sapiens_hsa05031	0.43064443
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.42634021
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42608658
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41709502
83	Bile secretion_Homo sapiens_hsa04976	0.40689629
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40675312
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39950906
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37769720
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37486871
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37004020
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36813570
90	Ras signaling pathway_Homo sapiens_hsa04014	0.35580756
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35001899
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33893142
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32805862
94	Cell cycle_Homo sapiens_hsa04110	0.32567802
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.29704825
96	Metabolic pathways_Homo sapiens_hsa01100	0.28851896
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.28508432
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.28456922
99	Mineral absorption_Homo sapiens_hsa04978	0.25547583
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.23278255

CTAGE14P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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