ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein targeting to Golgi (GO:0000042)	7.88690031
2	rRNA methylation (GO:0031167)	7.82070649
3	establishment of protein localization to Golgi (GO:0072600)	7.55537151
4	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.41258790
5	sperm motility (GO:0030317)	6.95022661
6	rRNA modification (GO:0000154)	6.78969853
7	cilium or flagellum-dependent cell motility (GO:0001539)	6.47768733
8	protein localization to Golgi apparatus (GO:0034067)	6.03354837
9	chromosome condensation (GO:0030261)	5.86631106
10	ventricular system development (GO:0021591)	5.84245317
11	fusion of sperm to egg plasma membrane (GO:0007342)	5.79674867
12	acrosome assembly (GO:0001675)	5.69411228
13	axonemal dynein complex assembly (GO:0070286)	5.68935693
14	nuclear pore complex assembly (GO:0051292)	5.67997887
15	acrosome reaction (GO:0007340)	5.42592708
16	single strand break repair (GO:0000012)	5.39298543
17	DNA packaging (GO:0006323)	5.36636695
18	binding of sperm to zona pellucida (GO:0007339)	5.25655099
19	motile cilium assembly (GO:0044458)	5.23033967
20	sperm-egg recognition (GO:0035036)	5.20201659
21	regulation of centriole replication (GO:0046599)	5.10519096
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.01106896
23	cilium movement (GO:0003341)	4.91466115
24	axoneme assembly (GO:0035082)	4.85787637
25	epithelial cilium movement (GO:0003351)	4.66555196
26	centriole replication (GO:0007099)	4.60977813
27	glomerular visceral epithelial cell development (GO:0072015)	4.56457746
28	nuclear pore organization (GO:0006999)	4.52544012
29	retinal rod cell development (GO:0046548)	4.35957245
30	microtubule polymerization or depolymerization (GO:0031109)	4.29636198
31	protein polyglutamylation (GO:0018095)	4.29230586
32	plasma membrane fusion (GO:0045026)	4.22924974
33	pore complex assembly (GO:0046931)	4.18771633
34	cell-cell recognition (GO:0009988)	4.13415087
35	sperm capacitation (GO:0048240)	4.10455624
36	multicellular organism reproduction (GO:0032504)	4.09295895
37	glomerular epithelial cell development (GO:0072310)	4.08848783
38	single fertilization (GO:0007338)	4.03394006
39	regulation of cilium movement (GO:0003352)	4.02455604
40	negative regulation of Rho protein signal transduction (GO:0035024)	3.91758060
41	spermatogenesis (GO:0007283)	3.90110041
42	male gamete generation (GO:0048232)	3.89497547
43	microtubule depolymerization (GO:0007019)	3.89263960
44	spermatid development (GO:0007286)	3.87334999
45	phenylpropanoid metabolic process (GO:0009698)	3.86748493
46	centriole assembly (GO:0098534)	3.76230391
47	spermatid nucleus differentiation (GO:0007289)	3.72661464
48	cellular glucuronidation (GO:0052695)	3.72558382
49	oxidative demethylation (GO:0070989)	3.65680353
50	gamete generation (GO:0007276)	3.59792914
51	fertilization (GO:0009566)	3.59751919
52	uronic acid metabolic process (GO:0006063)	3.56136813
53	glucuronate metabolic process (GO:0019585)	3.56136813
54	reproduction (GO:0000003)	3.53484727
55	cellular ketone body metabolic process (GO:0046950)	3.47724079
56	regulation of hippo signaling (GO:0035330)	3.38422310
57	intra-Golgi vesicle-mediated transport (GO:0006891)	3.38087474
58	histone H3-K9 demethylation (GO:0033169)	3.33862805
59	nucleus organization (GO:0006997)	3.29893612
60	drug catabolic process (GO:0042737)	3.28623911
61	auditory receptor cell differentiation (GO:0042491)	3.27278729
62	response to pheromone (GO:0019236)	3.25872408
63	seminiferous tubule development (GO:0072520)	3.19128090
64	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.18890674
65	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.14392678
66	early endosome to late endosome transport (GO:0045022)	3.13932156
67	glycerol ether metabolic process (GO:0006662)	3.13792986
68	retinal cone cell development (GO:0046549)	3.11365596
69	glyoxylate metabolic process (GO:0046487)	3.07838413
70	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.99447429
71	epithelial cell maturation (GO:0002070)	2.98941188
72	ketone body metabolic process (GO:1902224)	2.97071320
73	multicellular organismal reproductive process (GO:0048609)	2.92358425
74	cell wall macromolecule catabolic process (GO:0016998)	2.89781817
75	regulation of stem cell maintenance (GO:2000036)	2.89251628
76	maintenance of gastrointestinal epithelium (GO:0030277)	2.85792555
77	inner ear receptor cell differentiation (GO:0060113)	2.85498660
78	ether metabolic process (GO:0018904)	2.83522410
79	intestinal epithelial cell development (GO:0060576)	2.80283844
80	Golgi to endosome transport (GO:0006895)	2.79778807
81	amino-acid betaine metabolic process (GO:0006577)	2.76596302
82	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.75838649
83	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	2.74719828
84	L-phenylalanine metabolic process (GO:0006558)	2.74334042
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.74334042
86	regulation of gene silencing by RNA (GO:0060966)	2.73590951
87	regulation of posttranscriptional gene silencing (GO:0060147)	2.73590951
88	regulation of gene silencing by miRNA (GO:0060964)	2.73590951
89	coenzyme catabolic process (GO:0009109)	2.70778991
90	germ cell development (GO:0007281)	2.69092719
91	RNA methylation (GO:0001510)	2.68259620
92	calcium ion-dependent exocytosis (GO:0017156)	2.65251629
93	sexual reproduction (GO:0019953)	2.65054824
94	regulation of meiosis I (GO:0060631)	2.64039713
95	serine family amino acid catabolic process (GO:0009071)	2.63787558
96	glycine metabolic process (GO:0006544)	2.61868754
97	cell wall macromolecule metabolic process (GO:0044036)	2.61759905
98	metanephric nephron tubule development (GO:0072234)	2.60358158
99	metanephric tubule development (GO:0072170)	2.60358158
100	regulation of centrosome duplication (GO:0010824)	2.59715728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FUS_26573619_Chip-Seq_HEK293_Human	3.44638886
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.31524755
3	ER_23166858_ChIP-Seq_MCF-7_Human	2.65520079
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.51869041
5	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.49751237
6	CBP_20019798_ChIP-Seq_JUKART_Human	2.49751237
7	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.20419689
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.18512895
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12963735
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.08509372
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.07133580
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00556496
13	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.91349772
14	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.90245659
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89190693
16	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.87617389
17	VDR_22108803_ChIP-Seq_LS180_Human	1.82205403
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.76769740
19	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.76606067
20	CDX2_22108803_ChIP-Seq_LS180_Human	1.72150276
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71428634
22	RBPJ_21746931_ChIP-Seq_IB4_Human	1.69942742
23	TP63_23658742_ChIP-Seq_EP156T_Human	1.69313231
24	STAT3_23295773_ChIP-Seq_U87_Human	1.67349504
25	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.67343839
26	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.65551025
27	P300_19829295_ChIP-Seq_ESCs_Human	1.64466035
28	ETV1_20927104_ChIP-Seq_GIST48_Human	1.63821888
29	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63680834
30	PHF8_20622853_ChIP-Seq_HELA_Human	1.62903473
31	AHR_22903824_ChIP-Seq_MCF-7_Human	1.62636255
32	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.62617981
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.62495755
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.58745115
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57721664
36	NFYB_21822215_ChIP-Seq_K562_Human	1.56762842
37	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.52472648
38	TBL1_22424771_ChIP-Seq_293T_Human	1.51462816
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50789831
40	CJUN_26792858_Chip-Seq_BT549_Human	1.50095398
41	NFYA_21822215_ChIP-Seq_K562_Human	1.50022652
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49674796
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49390853
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48780443
45	AR_25329375_ChIP-Seq_VCAP_Human	1.48426855
46	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.47247546
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46789326
48	RUNX2_22187159_ChIP-Seq_PCA_Human	1.45300473
49	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.43803842
50	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.39591965
51	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.38906979
52	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.38718791
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38629105
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38552039
55	GATA4_25053715_ChIP-Seq_YYC3_Human	1.36577809
56	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.36107396
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35863601
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35171352
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35171352
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.34587513
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31573103
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.30905159
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30832959
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.30501532
65	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.29733036
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27467020
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27090910
68	CBP_21632823_ChIP-Seq_H3396_Human	1.26747294
69	AR_20517297_ChIP-Seq_VCAP_Human	1.26382079
70	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.24359490
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.24141515
72	GATA6_25053715_ChIP-Seq_YYC3_Human	1.23804113
73	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23353926
74	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.23258090
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22728474
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22728474
77	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22223273
78	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.21879231
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21540143
80	TCF4_23295773_ChIP-Seq_U87_Human	1.20979502
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19873125
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.19669074
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18963018
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18728489
85	EWS_26573619_Chip-Seq_HEK293_Human	1.18658672
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17019205
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16780628
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15239991
89	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.14889053
90	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.11876681
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09837827
92	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.09670288
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09600570
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09582158
95	KDM2B_26808549_Chip-Seq_REH_Human	1.06626595
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06580745
97	BCAT_22108803_ChIP-Seq_LS180_Human	1.04906262
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04900724
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04900724
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04779596

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.67911160
2	MP0009697_abnormal_copulation	3.95132907
3	MP0005085_abnormal_gallbladder_physiolo	3.82895494
4	MP0003195_calcinosis	3.70997575
5	MP0005360_urolithiasis	3.52942290
6	MP0002138_abnormal_hepatobiliary_system	3.46769523
7	MP0003252_abnormal_bile_duct	3.25306555
8	MP0002139_abnormal_hepatobiliary_system	2.75676937
9	MP0003646_muscle_fatigue	2.62940080
10	MP0005332_abnormal_amino_acid	2.60810847
11	MP0005670_abnormal_white_adipose	2.58377334
12	MP0003868_abnormal_feces_composition	2.57355263
13	MP0001661_extended_life_span	2.46636318
14	MP0001666_abnormal_nutrient_absorption	2.39414499
15	MP0010234_abnormal_vibrissa_follicle	2.35616157
16	MP0001929_abnormal_gametogenesis	2.27139113
17	MP0003698_abnormal_male_reproductive	2.24678225
18	MP0004233_abnormal_muscle_weight	2.15292862
19	MP0008875_abnormal_xenobiotic_pharmacok	2.13536842
20	MP0004043_abnormal_pH_regulation	2.09221790
21	MP0005365_abnormal_bile_salt	2.07134874
22	MP0008057_abnormal_DNA_replication	2.06703036
23	MP0005377_hearing/vestibular/ear_phenot	2.02846878
24	MP0003878_abnormal_ear_physiology	2.02846878
25	MP0005408_hypopigmentation	1.72758280
26	MP0003718_maternal_effect	1.71403556
27	MP0004957_abnormal_blastocyst_morpholog	1.69134909
28	MP0002928_abnormal_bile_duct	1.61886183
29	MP0003941_abnormal_skin_development	1.57656319
30	MP0002876_abnormal_thyroid_physiology	1.57223458
31	MP0010678_abnormal_skin_adnexa	1.52010900
32	MP0004264_abnormal_extraembryonic_tissu	1.39331169
33	MP0003566_abnormal_cell_adhesion	1.39277242
34	MP0009643_abnormal_urine_homeostasis	1.37728141
35	MP0004272_abnormal_basement_membrane	1.33516090
36	MP0005395_other_phenotype	1.33239552
37	MP0002282_abnormal_trachea_morphology	1.32898352
38	MP0004019_abnormal_vitamin_homeostasis	1.32774061
39	MP0005310_abnormal_salivary_gland	1.28748007
40	MP0000678_abnormal_parathyroid_gland	1.28553693
41	MP0005636_abnormal_mineral_homeostasis	1.24453177
42	MP0001765_abnormal_ion_homeostasis	1.20864346
43	MP0001348_abnormal_lacrimal_gland	1.20026291
44	MP0002210_abnormal_sex_determination	1.17308079
45	MP0004782_abnormal_surfactant_physiolog	1.16776757
46	MP0001485_abnormal_pinna_reflex	1.16118869
47	MP0002161_abnormal_fertility/fecundity	1.14504143
48	MP0008058_abnormal_DNA_repair	1.12671704
49	MP0000579_abnormal_nail_morphology	1.11469237
50	MP0003283_abnormal_digestive_organ	1.09443294
51	MP0002796_impaired_skin_barrier	1.08925894
52	MP0005319_abnormal_enzyme/_coenzyme	1.06652954
53	MP0005220_abnormal_exocrine_pancreas	1.06510709
54	MP0001145_abnormal_male_reproductive	1.04420669
55	MP0002132_abnormal_respiratory_system	1.03782797
56	MP0000653_abnormal_sex_gland	1.01980001
57	MP0008877_abnormal_DNA_methylation	1.01701130
58	MP0003943_abnormal_hepatobiliary_system	0.99084893
59	MP0003950_abnormal_plasma_membrane	0.98605539
60	MP0005379_endocrine/exocrine_gland_phen	0.96837102
61	MP0005083_abnormal_biliary_tract	0.93199011
62	MP0003806_abnormal_nucleotide_metabolis	0.91438158
63	MP0002168_other_aberrant_phenotype	0.89585911
64	MP0003693_abnormal_embryo_hatching	0.87281313
65	MP0002136_abnormal_kidney_physiology	0.87213198
66	MP0008007_abnormal_cellular_replicative	0.86656871
67	MP0000383_abnormal_hair_follicle	0.84729941
68	MP0002060_abnormal_skin_morphology	0.84702674
69	MP0000762_abnormal_tongue_morphology	0.84188880
70	MP0000470_abnormal_stomach_morphology	0.83725715
71	MP0002249_abnormal_larynx_morphology	0.82903636
72	MP0010352_gastrointestinal_tract_polyps	0.82883924
73	MP0000427_abnormal_hair_cycle	0.82082706
74	MP0010307_abnormal_tumor_latency	0.80434797
75	MP0003879_abnormal_hair_cell	0.80335328
76	MP0003656_abnormal_erythrocyte_physiolo	0.80191873
77	MP0009053_abnormal_anal_canal	0.80048441
78	MP0005551_abnormal_eye_electrophysiolog	0.79999221
79	MP0003959_abnormal_lean_body	0.79599539
80	MP0001764_abnormal_homeostasis	0.79456536
81	MP0000467_abnormal_esophagus_morphology	0.78415648
82	MP0010094_abnormal_chromosome_stability	0.77592478
83	MP0000566_synostosis	0.77371009
84	MP0008961_abnormal_basal_metabolism	0.76034893
85	MP0010329_abnormal_lipoprotein_level	0.74253902
86	MP0004133_heterotaxia	0.73069264
87	MP0003011_delayed_dark_adaptation	0.72380816
88	MP0001881_abnormal_mammary_gland	0.67971136
89	MP0003077_abnormal_cell_cycle	0.67635288
90	MP0002118_abnormal_lipid_homeostasis	0.66419045
91	MP0009115_abnormal_fat_cell	0.66123318
92	MP0001730_embryonic_growth_arrest	0.64876380
93	MP0002269_muscular_atrophy	0.64258676
94	MP0005645_abnormal_hypothalamus_physiol	0.63981470
95	MP0002108_abnormal_muscle_morphology	0.62538872
96	MP0002160_abnormal_reproductive_system	0.62250386
97	MP0005253_abnormal_eye_physiology	0.61592765
98	MP0000609_abnormal_liver_physiology	0.56076738
99	MP0000230_abnormal_systemic_arterial	0.55456244
100	MP0001984_abnormal_olfaction	0.55322120

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	6.38829864
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.38829864
3	Chronic hepatic failure (HP:0100626)	5.90402847
4	Tubulointerstitial nephritis (HP:0001970)	5.76574458
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.93563678
6	Cone-rod dystrophy (HP:0000548)	4.64777424
7	Abnormal ciliary motility (HP:0012262)	4.26520620
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.25765448
9	Chronic bronchitis (HP:0004469)	4.05310681
10	Focal segmental glomerulosclerosis (HP:0000097)	3.73733574
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.71594274
12	Abnormal respiratory motile cilium morphology (HP:0005938)	3.71594274
13	Hypoalphalipoproteinemia (HP:0003233)	3.65473476
14	Hyperactive renin-angiotensin system (HP:0000841)	3.54983142
15	Progressive sensorineural hearing impairment (HP:0000408)	3.49394903
16	Subcapsular cataract (HP:0000523)	3.39780849
17	Menstrual irregularities (HP:0000858)	3.39151041
18	Generalized aminoaciduria (HP:0002909)	3.38838542
19	Increased purine levels (HP:0004368)	3.26107792
20	Hyperuricemia (HP:0002149)	3.26107792
21	Glomerulosclerosis (HP:0000096)	3.24803086
22	Metaphyseal dysplasia (HP:0100255)	3.18378889
23	Microglossia (HP:0000171)	3.18236055
24	Intrahepatic cholestasis (HP:0001406)	3.18131653
25	Bony spicule pigmentary retinopathy (HP:0007737)	3.06165299
26	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.96706156
27	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.89897962
28	Abnormality of chloride homeostasis (HP:0011422)	2.87790231
29	Male infertility (HP:0003251)	2.84404654
30	Hyperkalemia (HP:0002153)	2.82173759
31	Abnormality of purine metabolism (HP:0004352)	2.79252542
32	Amelogenesis imperfecta (HP:0000705)	2.76101738
33	Median cleft lip (HP:0000161)	2.72846568
34	Rhinitis (HP:0012384)	2.71927576
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.69688747
36	Nasal polyposis (HP:0100582)	2.68918735
37	Abnormality of nucleobase metabolism (HP:0010932)	2.68000746
38	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.66564977
39	Lip pit (HP:0100267)	2.66476276
40	Hypolipoproteinemia (HP:0010981)	2.65297388
41	Resting tremor (HP:0002322)	2.64340540
42	Abnormality of macular pigmentation (HP:0008002)	2.63220659
43	Bronchiectasis (HP:0002110)	2.62179764
44	Severe visual impairment (HP:0001141)	2.55801193
45	Renovascular hypertension (HP:0100817)	2.49092534
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.46891098
47	Progressive hearing impairment (HP:0001730)	2.46253765
48	Abnormality of pyrimidine metabolism (HP:0004353)	2.43451373
49	Renal salt wasting (HP:0000127)	2.43259334
50	Prolonged partial thromboplastin time (HP:0003645)	2.42317329
51	Chorioretinal atrophy (HP:0000533)	2.40390516
52	Tubulointerstitial abnormality (HP:0001969)	2.40090338
53	Stage 5 chronic kidney disease (HP:0003774)	2.38921024
54	Abnormality of lateral ventricle (HP:0030047)	2.32429316
55	Portal hypertension (HP:0001409)	2.31434541
56	Abnormality of the renal medulla (HP:0100957)	2.31224448
57	Insulin-resistant diabetes mellitus (HP:0000831)	2.29296134
58	Reduced antithrombin III activity (HP:0001976)	2.27218243
59	Prolonged neonatal jaundice (HP:0006579)	2.24671428
60	Pili torti (HP:0003777)	2.24666545
61	Attenuation of retinal blood vessels (HP:0007843)	2.22603861
62	Polar cataract (HP:0010696)	2.20261548
63	Abnormality of the nasal septum (HP:0000419)	2.19656400
64	Hyperaldosteronism (HP:0000859)	2.19493411
65	Infertility (HP:0000789)	2.17672898
66	Intellectual disability, moderate (HP:0002342)	2.17036965
67	Abnormal biliary tract morphology (HP:0012440)	2.16962170
68	Hypergonadotropic hypogonadism (HP:0000815)	2.15643719
69	Bronchitis (HP:0012387)	2.12158543
70	Asymmetric septal hypertrophy (HP:0001670)	2.12004011
71	Abnormality of the hepatic vasculature (HP:0006707)	2.10200441
72	Biliary tract neoplasm (HP:0100574)	2.09783358
73	Abnormality of renal excretion (HP:0011036)	2.06620456
74	Abnormality of potassium homeostasis (HP:0011042)	2.06587396
75	Hypophosphatemic rickets (HP:0004912)	2.04288738
76	Goiter (HP:0000853)	2.02442404
77	Rickets (HP:0002748)	2.02111670
78	Hyponatremia (HP:0002902)	1.98852087
79	Glycosuria (HP:0003076)	1.98371619
80	Abnormality of urine glucose concentration (HP:0011016)	1.98371619
81	Gout (HP:0001997)	1.95401129
82	Papillary thyroid carcinoma (HP:0002895)	1.94575013
83	Exocrine pancreatic insufficiency (HP:0001738)	1.92966136
84	Hypokalemic alkalosis (HP:0001949)	1.90576923
85	Increased circulating renin level (HP:0000848)	1.89246669
86	Polyuria (HP:0000103)	1.86443034
87	Abnormal urine output (HP:0012590)	1.86081862
88	Milia (HP:0001056)	1.84720135
89	Scotoma (HP:0000575)	1.83473297
90	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.83155824
91	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.83098193
92	Tubular atrophy (HP:0000092)	1.82283362
93	Bilateral sensorineural hearing impairment (HP:0008619)	1.81069152
94	Metabolic alkalosis (HP:0200114)	1.80617730
95	Abnormality of the nasal mucosa (HP:0000433)	1.80509415
96	Enlarged epiphyses (HP:0010580)	1.79091290
97	Osteomalacia (HP:0002749)	1.77405896
98	Confusion (HP:0001289)	1.77007692
99	Vertebral arch anomaly (HP:0008438)	1.76977516
100	Neoplasm of striated muscle (HP:0009728)	1.75125053

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	7.04966294
2	MST1R	5.15334133
3	PLK4	5.10679520
4	NTRK1	3.05569055
5	STK24	2.70680808
6	MAP3K2	2.68296356
7	STK39	2.68152346
8	MET	2.46944201
9	BRD4	2.37157361
10	MST4	2.28751320
11	STK38L	2.25933725
12	INSRR	2.20421103
13	PNCK	2.17607900
14	WNK4	2.16343572
15	OXSR1	2.14171950
16	PIK3CG	2.11195819
17	LATS1	1.81930696
18	NME1	1.79309223
19	TNIK	1.76167067
20	FRK	1.75499138
21	MAP4K2	1.66517421
22	CDK12	1.62673869
23	EPHA2	1.53834103
24	CAMK1G	1.47066261
25	PLK2	1.44204738
26	WNK1	1.36478628
27	KSR2	1.36232522
28	MAP3K12	1.28269456
29	MKNK2	1.24881582
30	WNK3	1.15685759
31	TSSK6	1.13505060
32	ZAP70	1.06181804
33	TRPM7	0.97420382
34	PBK	0.95153197
35	NTRK2	0.89687292
36	STK38	0.89587097
37	ACVR1B	0.89024696
38	TTK	0.88440689
39	BMPR1B	0.83725068
40	PRKD3	0.83257478
41	NTRK3	0.82441297
42	BRSK2	0.81384532
43	STK3	0.78947869
44	EIF2AK1	0.77029288
45	STK16	0.74619270
46	TESK1	0.74600530
47	PRKG2	0.70682304
48	MAP3K9	0.66811496
49	EIF2AK3	0.60099342
50	PTK2B	0.59139028
51	SRPK1	0.58952373
52	PLK1	0.57362298
53	ERBB3	0.56189145
54	NEK6	0.53519512
55	CAMK1D	0.52775609
56	MAPKAPK3	0.52561229
57	BCR	0.51580592
58	MAP3K7	0.48666465
59	TRIM28	0.47119794
60	ERBB4	0.44609400
61	FER	0.44419113
62	CDK7	0.41416173
63	BRAF	0.39751937
64	LMTK2	0.39091073
65	MUSK	0.35145522
66	MKNK1	0.34993017
67	MAP2K1	0.34325155
68	LATS2	0.33936059
69	MAPK15	0.33272542
70	FLT3	0.32935293
71	MTOR	0.32277083
72	PRKG1	0.32241001
73	AKT3	0.29674004
74	PRKCE	0.28981953
75	MAP3K1	0.27338123
76	SGK1	0.26721857
77	CSNK1E	0.26599971
78	CDK1	0.26030531
79	MAPK1	0.24999182
80	CHEK1	0.24908226
81	PDPK1	0.24339984
82	CDK9	0.23172007
83	YES1	0.20895997
84	PRKAA2	0.19383055
85	BMPR2	0.18685893
86	EGFR	0.18384969
87	RPS6KB2	0.17205548
88	AKT1	0.16300212
89	CDC42BPA	0.16278784
90	STK11	0.15590093
91	PDK1	0.15459895
92	PRKAA1	0.14723758
93	EEF2K	0.14339664
94	CDK3	0.13710700
95	PTK2	0.13473412
96	KSR1	0.13364971
97	AURKB	0.12877057
98	MAP3K8	0.11680426
99	MYLK	0.10817702
100	MAPK14	0.10010581

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	4.26624242
2	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.30829589
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.11846107
4	Retinol metabolism_Homo sapiens_hsa00830	2.66992592
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.63492664
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.59694752
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33878811
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.33518814
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32840175
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.32121854
11	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.19667074
12	Chemical carcinogenesis_Homo sapiens_hsa05204	2.18341275
13	Phenylalanine metabolism_Homo sapiens_hsa00360	2.03237508
14	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.03197801
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.98726879
16	Fatty acid degradation_Homo sapiens_hsa00071	1.80834287
17	ABC transporters_Homo sapiens_hsa02010	1.78280570
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.77765459
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77320551
20	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.75158476
21	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.68613893
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60563955
23	Histidine metabolism_Homo sapiens_hsa00340	1.59803509
24	Olfactory transduction_Homo sapiens_hsa04740	1.59605395
25	RNA transport_Homo sapiens_hsa03013	1.57516744
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55375466
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.53939119
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.49327106
29	Basal transcription factors_Homo sapiens_hsa03022	1.45467588
30	Caffeine metabolism_Homo sapiens_hsa00232	1.43951953
31	Lysine degradation_Homo sapiens_hsa00310	1.40229042
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.39338836
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.34105382
34	Bile secretion_Homo sapiens_hsa04976	1.33514626
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32936650
36	Butanoate metabolism_Homo sapiens_hsa00650	1.31250959
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.13414348
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10027815
39	Complement and coagulation cascades_Homo sapiens_hsa04610	1.07234883
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.04584928
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02657831
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.02564957
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.99812830
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98944572
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.97480911
46	Propanoate metabolism_Homo sapiens_hsa00640	0.97265468
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.96859626
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94363487
49	Folate biosynthesis_Homo sapiens_hsa00790	0.90761860
50	Peroxisome_Homo sapiens_hsa04146	0.89477970
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84382729
52	ECM-receptor interaction_Homo sapiens_hsa04512	0.81302113
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79322648
54	Oocyte meiosis_Homo sapiens_hsa04114	0.74700511
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73672268
56	Type II diabetes mellitus_Homo sapiens_hsa04930	0.73614572
57	Mismatch repair_Homo sapiens_hsa03430	0.72528847
58	Adherens junction_Homo sapiens_hsa04520	0.71564139
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.70547160
60	One carbon pool by folate_Homo sapiens_hsa00670	0.69578062
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.65973534
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.64966568
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64880102
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.63193992
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61447959
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61000600
67	Metabolic pathways_Homo sapiens_hsa01100	0.55922025
68	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55519021
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55167655
70	Taste transduction_Homo sapiens_hsa04742	0.55014848
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54990150
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54828705
73	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54392320
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.53701924
75	Sulfur metabolism_Homo sapiens_hsa00920	0.53607640
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46457781
77	Carbon metabolism_Homo sapiens_hsa01200	0.45076762
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42402934
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41961194
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41807427
81	Estrogen signaling pathway_Homo sapiens_hsa04915	0.41616744
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41295069
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.41027038
84	Glutathione metabolism_Homo sapiens_hsa00480	0.40098440
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.39649936
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.39364714
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38805260
88	Galactose metabolism_Homo sapiens_hsa00052	0.36848810
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.36524554
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34608480
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33407232
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33001713
93	Homologous recombination_Homo sapiens_hsa03440	0.32462720
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.29154660
95	Thyroid cancer_Homo sapiens_hsa05216	0.28129437
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.27617236
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.26956233
98	Purine metabolism_Homo sapiens_hsa00230	0.26768087
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.26410448
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.26152868

CTAGE15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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