ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of systemic arterial blood pressure (GO:0003084)	6.38544003
2	regulation of hypersensitivity (GO:0002883)	6.20671926
3	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	6.12342280
4	interferon-gamma production (GO:0032609)	5.93502680
5	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.47593204
6	regulation of urine volume (GO:0035809)	4.49137705
7	negative regulation of activin receptor signaling pathway (GO:0032926)	4.39886926
8	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	4.28497657
9	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.21495140
10	ovulation from ovarian follicle (GO:0001542)	4.18861797
11	regulation of renal sodium excretion (GO:0035813)	4.17220671
12	telencephalon development (GO:0021537)	4.17156791
13	very-low-density lipoprotein particle assembly (GO:0034379)	4.01446012
14	synapsis (GO:0007129)	3.84712510
15	plasma lipoprotein particle assembly (GO:0034377)	3.81077897
16	positive regulation of vascular permeability (GO:0043117)	3.75015201
17	regulation of excretion (GO:0044062)	3.73121595
18	protein targeting to Golgi (GO:0000042)	3.72762366
19	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.69441494
20	positive regulation of mast cell degranulation (GO:0043306)	3.69441494
21	protein-lipid complex assembly (GO:0065005)	3.67340771
22	establishment of protein localization to Golgi (GO:0072600)	3.64776602
23	resolution of meiotic recombination intermediates (GO:0000712)	3.61893631
24	C4-dicarboxylate transport (GO:0015740)	3.61035054
25	negative regulation of amino acid transport (GO:0051956)	3.58524610
26	piRNA metabolic process (GO:0034587)	3.55554941
27	meiotic chromosome segregation (GO:0045132)	3.52366351
28	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.43112507
29	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.36810669
30	regulation of centriole replication (GO:0046599)	3.36280134
31	chromatin remodeling at centromere (GO:0031055)	3.33086381
32	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	3.28831957
33	CENP-A containing nucleosome assembly (GO:0034080)	3.28011572
34	regulation of DNA endoreduplication (GO:0032875)	3.17007808
35	histone mRNA catabolic process (GO:0071044)	3.14089343
36	heme transport (GO:0015886)	3.12648200
37	pyrimidine dimer repair (GO:0006290)	3.12244181
38	positive regulation of leukocyte degranulation (GO:0043302)	3.11743913
39	histone mRNA metabolic process (GO:0008334)	3.10920340
40	carnitine shuttle (GO:0006853)	3.08628634
41	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.02275281
42	mitotic chromosome condensation (GO:0007076)	3.00951214
43	dendritic spine organization (GO:0097061)	2.98996126
44	histone exchange (GO:0043486)	2.97911912
45	peripheral nervous system neuron development (GO:0048935)	2.96770502
46	SMAD protein signal transduction (GO:0060395)	2.92713741
47	regulation of helicase activity (GO:0051095)	2.90034754
48	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.89881936
49	short-term memory (GO:0007614)	2.86620705
50	dendritic spine morphogenesis (GO:0060997)	2.84558848
51	triglyceride homeostasis (GO:0070328)	2.83885630
52	acylglycerol homeostasis (GO:0055090)	2.83885630
53	negative regulation of vascular permeability (GO:0043116)	2.83686821
54	regulation of glutamate secretion (GO:0014048)	2.83293937
55	regulation of histone H3-K27 methylation (GO:0061085)	2.81618627
56	galactose catabolic process (GO:0019388)	2.78041461
57	one-carbon compound transport (GO:0019755)	2.77812051
58	negative regulation of fibroblast apoptotic process (GO:2000270)	2.77333421
59	negative regulation of T cell differentiation in thymus (GO:0033085)	2.76208479
60	L-serine transport (GO:0015825)	2.75570755
61	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.75050101
62	positive regulation of histone methylation (GO:0031062)	2.74424951
63	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.74366845
64	regulation of somitogenesis (GO:0014807)	2.74009535
65	gene silencing by RNA (GO:0031047)	2.73201665
66	high-density lipoprotein particle remodeling (GO:0034375)	2.72170569
67	fatty acid transmembrane transport (GO:1902001)	2.71164713
68	phospholipid efflux (GO:0033700)	2.70495997
69	DNA methylation involved in gamete generation (GO:0043046)	2.69976700
70	amino-acid betaine transport (GO:0015838)	2.68378521
71	carnitine transport (GO:0015879)	2.68378521
72	cholesterol efflux (GO:0033344)	2.66475065
73	regulation of cholesterol esterification (GO:0010872)	2.65674251
74	regulation of histone H3-K9 methylation (GO:0051570)	2.62500353
75	viral mRNA export from host cell nucleus (GO:0046784)	2.61907524
76	lipoprotein transport (GO:0042953)	2.61247320
77	chromosome condensation (GO:0030261)	2.60174166
78	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.60054784
79	regulation of DNA damage checkpoint (GO:2000001)	2.59242982
80	carnitine transmembrane transport (GO:1902603)	2.58286463
81	protein localization to Golgi apparatus (GO:0034067)	2.57696006
82	phosphatidylethanolamine metabolic process (GO:0046337)	2.57291265
83	regulation of bile acid biosynthetic process (GO:0070857)	2.57253152
84	cGMP-mediated signaling (GO:0019934)	2.55977264
85	water transport (GO:0006833)	2.55697664
86	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	2.53373208
87	cartilage morphogenesis (GO:0060536)	2.53025097
88	regulation of centrosome duplication (GO:0010824)	2.52114708
89	positive regulation of mast cell activation (GO:0033005)	2.51456869
90	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.50366585
91	negative regulation of DNA recombination (GO:0045910)	2.49839874
92	L-alpha-amino acid transmembrane transport (GO:1902475)	2.49773436
93	metaphase plate congression (GO:0051310)	2.47728728
94	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.46331629
95	chromatin assembly (GO:0031497)	2.45642818
96	negative regulation of DNA repair (GO:0045738)	2.44483898
97	DNA replication-independent nucleosome assembly (GO:0006336)	2.44367042
98	DNA replication-independent nucleosome organization (GO:0034724)	2.44367042
99	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.43386348
100	cellular response to BMP stimulus (GO:0071773)	2.43258619

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.80891365
2	E2F7_22180533_ChIP-Seq_HELA_Human	5.72584295
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.78689082
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.35231163
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.20961974
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.61390329
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.58833283
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.30586004
9	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.26453185
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.25966922
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.15207162
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13968197
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.08406813
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.05950287
15	RNF2_27304074_Chip-Seq_NSC_Mouse	1.94941542
16	VDR_22108803_ChIP-Seq_LS180_Human	1.94321604
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94064514
18	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.84876905
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78206492
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70621312
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.67261035
22	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.65490005
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64169915
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.64128352
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.56731143
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54744339
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52853963
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49544207
29	FUS_26573619_Chip-Seq_HEK293_Human	1.45462087
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44344920
31	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.43694936
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.41863897
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41434859
34	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.39683027
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37975737
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37823470
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37159735
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36031630
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34183448
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.33601221
41	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.31825365
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.31176829
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30598059
44	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.29435521
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.27121119
46	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.25521066
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25452137
48	ZNF263_19887448_ChIP-Seq_K562_Human	1.25385360
49	TP53_16413492_ChIP-PET_HCT116_Human	1.25039174
50	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24034937
51	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.22436648
52	ETV1_20927104_ChIP-Seq_GIST48_Human	1.21122125
53	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20401643
54	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.19078139
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17929540
56	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.17826859
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14289391
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13038353
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12526971
60	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.12251036
61	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.11389048
62	EWS_26573619_Chip-Seq_HEK293_Human	1.10809028
63	TCF4_23295773_ChIP-Seq_U87_Human	1.10044156
64	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09195105
65	P300_19829295_ChIP-Seq_ESCs_Human	1.07953333
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06832298
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.06709715
68	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06371443
69	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.05420490
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05296166
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03071888
72	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.01514138
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01009647
74	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00016079
75	GBX2_23144817_ChIP-Seq_PC3_Human	0.99978455
76	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99772873
77	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98859147
78	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98724529
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98051069
80	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.96415244
81	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.95380364
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.93788326
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93380841
84	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93157739
85	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.92374893
86	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.92373835
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90449911
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89946130
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89946130
90	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.89945135
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89342525
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.88297434
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87683137
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.87610273
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86825949
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86825949
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.85849161
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.85704700
99	DCP1A_22483619_ChIP-Seq_HELA_Human	0.84977316
100	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.84776461

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.21915336
2	MP0004147_increased_porphyrin_level	3.47050762
3	MP0005360_urolithiasis	3.39110029
4	MP0010368_abnormal_lymphatic_system	3.16831419
5	MP0001984_abnormal_olfaction	2.90811803
6	MP0008877_abnormal_DNA_methylation	2.82203587
7	MP0002638_abnormal_pupillary_reflex	2.78587688
8	MP0001529_abnormal_vocalization	2.52912286
9	MP0003950_abnormal_plasma_membrane	2.47030273
10	MP0003567_abnormal_fetal_cardiomyocyte	2.31133374
11	MP0005410_abnormal_fertilization	2.03093079
12	MP0009697_abnormal_copulation	1.99313444
13	MP0001661_extended_life_span	1.97124143
14	MP0005083_abnormal_biliary_tract	1.95099246
15	MP0003111_abnormal_nucleus_morphology	1.94467105
16	MP0010094_abnormal_chromosome_stability	1.90278717
17	MP0002822_catalepsy	1.80686145
18	MP0004084_abnormal_cardiac_muscle	1.71109253
19	MP0004215_abnormal_myocardial_fiber	1.70703764
20	MP0002160_abnormal_reproductive_system	1.67893473
21	MP0004145_abnormal_muscle_electrophysio	1.64351823
22	MP0005365_abnormal_bile_salt	1.63188500
23	MP0003890_abnormal_embryonic-extraembry	1.61755694
24	MP0003693_abnormal_embryo_hatching	1.60735002
25	MP0003656_abnormal_erythrocyte_physiolo	1.56605756
26	MP0005084_abnormal_gallbladder_morpholo	1.48233276
27	MP0004957_abnormal_blastocyst_morpholog	1.47476776
28	MP0010329_abnormal_lipoprotein_level	1.46357827
29	MP0001756_abnormal_urination	1.46286781
30	MP0005085_abnormal_gallbladder_physiolo	1.46204132
31	MP0001929_abnormal_gametogenesis	1.44410123
32	MP0003698_abnormal_male_reproductive	1.42671170
33	MP0008775_abnormal_heart_ventricle	1.39805400
34	MP0003183_abnormal_peptide_metabolism	1.36527459
35	MP0003123_paternal_imprinting	1.36196803
36	MP0008995_early_reproductive_senescence	1.35303944
37	MP0002210_abnormal_sex_determination	1.34536736
38	MP0009046_muscle_twitch	1.29199057
39	MP0009384_cardiac_valve_regurgitation	1.29135474
40	MP0005636_abnormal_mineral_homeostasis	1.25610919
41	MP0004264_abnormal_extraembryonic_tissu	1.16279777
42	MP0006138_congestive_heart_failure	1.14342784
43	MP0001873_stomach_inflammation	1.13509921
44	MP0000653_abnormal_sex_gland	1.12373327
45	MP0008058_abnormal_DNA_repair	1.11966510
46	MP0003122_maternal_imprinting	1.11460669
47	MP0003718_maternal_effect	1.06681075
48	MP0001145_abnormal_male_reproductive	1.06394306
49	MP0002269_muscular_atrophy	1.05993452
50	MP0005171_absent_coat_pigmentation	1.04023661
51	MP0003136_yellow_coat_color	1.02663982
52	MP0005647_abnormal_sex_gland	1.01802921
53	MP0000566_synostosis	1.01318714
54	MP0000372_irregular_coat_pigmentation	0.97798520
55	MP0005551_abnormal_eye_electrophysiolog	0.97678736
56	MP0005670_abnormal_white_adipose	0.97080165
57	MP0001664_abnormal_digestion	0.96900094
58	MP0006035_abnormal_mitochondrial_morpho	0.95443680
59	MP0000516_abnormal_urinary_system	0.94832406
60	MP0005367_renal/urinary_system_phenotyp	0.94832406
61	MP0002139_abnormal_hepatobiliary_system	0.90078818
62	MP0002249_abnormal_larynx_morphology	0.89173119
63	MP0000678_abnormal_parathyroid_gland	0.89110938
64	MP0002161_abnormal_fertility/fecundity	0.88909981
65	MP0003690_abnormal_glial_cell	0.87658707
66	MP0004142_abnormal_muscle_tone	0.85430559
67	MP0005266_abnormal_metabolism	0.85232029
68	MP0005167_abnormal_blood-brain_barrier	0.85038205
69	MP0003646_muscle_fatigue	0.84855777
70	MP0002972_abnormal_cardiac_muscle	0.84115904
71	MP0001730_embryonic_growth_arrest	0.84110586
72	MP0001765_abnormal_ion_homeostasis	0.84010315
73	MP0005380_embryogenesis_phenotype	0.83478869
74	MP0001672_abnormal_embryogenesis/_devel	0.83478869
75	MP0003121_genomic_imprinting	0.82292507
76	MP0002127_abnormal_cardiovascular_syste	0.80273422
77	MP0005332_abnormal_amino_acid	0.79911812
78	MP0002697_abnormal_eye_size	0.79568046
79	MP0003786_premature_aging	0.79194261
80	MP0001340_abnormal_eyelid_morphology	0.79046764
81	MP0001348_abnormal_lacrimal_gland	0.78186313
82	MP0005389_reproductive_system_phenotype	0.78175936
83	MP0001485_abnormal_pinna_reflex	0.77830242
84	MP0005408_hypopigmentation	0.76721452
85	MP0001544_abnormal_cardiovascular_syste	0.75726622
86	MP0005385_cardiovascular_system_phenoty	0.75726622
87	MP0002233_abnormal_nose_morphology	0.75695641
88	MP0003937_abnormal_limbs/digits/tail_de	0.74089750
89	MP0008007_abnormal_cellular_replicative	0.73531219
90	MP0010630_abnormal_cardiac_muscle	0.73434748
91	MP0001879_abnormal_lymphatic_vessel	0.72427722
92	MP0001293_anophthalmia	0.71836136
93	MP0009672_abnormal_birth_weight	0.71535375
94	MP0002088_abnormal_embryonic_growth/wei	0.71315653
95	MP0003221_abnormal_cardiomyocyte_apopto	0.71044704
96	MP0005503_abnormal_tendon_morphology	0.70175939
97	MP0003984_embryonic_growth_retardation	0.69298389
98	MP0003941_abnormal_skin_development	0.68796048
99	MP0002114_abnormal_axial_skeleton	0.68672793
100	MP0003699_abnormal_female_reproductive	0.68360370

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased circulating renin level (HP:0003351)	9.21339820
2	Abnormal drinking behavior (HP:0030082)	5.79070525
3	Polydipsia (HP:0001959)	5.79070525
4	Hyponatremia (HP:0002902)	5.65163894
5	Abnormality of renin-angiotensin system (HP:0000847)	5.01849421
6	Abnormality of sodium homeostasis (HP:0010931)	4.38028331
7	Polyuria (HP:0000103)	3.99609311
8	Septate vagina (HP:0001153)	3.83484053
9	Neonatal onset (HP:0003623)	3.83083004
10	Abnormal urine output (HP:0012590)	3.71759599
11	Acanthocytosis (HP:0001927)	3.53028798
12	Hypobetalipoproteinemia (HP:0003563)	3.51697283
13	Poikilocytosis (HP:0004447)	3.37187853
14	Hypoparathyroidism (HP:0000829)	3.13535991
15	Renal cortical cysts (HP:0000803)	3.12096535
16	Abnormality of the common coagulation pathway (HP:0010990)	3.07731902
17	Abnormality of renal excretion (HP:0011036)	3.03838207
18	Rectovaginal fistula (HP:0000143)	2.86829195
19	Rectal fistula (HP:0100590)	2.86829195
20	Deep venous thrombosis (HP:0002625)	2.80416971
21	Abnormality of the 2nd finger (HP:0004100)	2.74865295
22	Vaginal fistula (HP:0004320)	2.74798905
23	Reticulocytosis (HP:0001923)	2.72878511
24	Osteomalacia (HP:0002749)	2.69047670
25	Increased serum pyruvate (HP:0003542)	2.68609806
26	Broad alveolar ridges (HP:0000187)	2.61514820
27	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.61254077
28	Intestinal fistula (HP:0100819)	2.58757808
29	Fair hair (HP:0002286)	2.49975375
30	Generalized aminoaciduria (HP:0002909)	2.44758119
31	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.43710889
32	Abnormality of alanine metabolism (HP:0010916)	2.41370403
33	Hyperalaninemia (HP:0003348)	2.41370403
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41370403
35	Papillary thyroid carcinoma (HP:0002895)	2.39943019
36	Scotoma (HP:0000575)	2.39253926
37	Birth length less than 3rd percentile (HP:0003561)	2.35577269
38	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.27656482
39	Nausea (HP:0002018)	2.21801612
40	Drooling (HP:0002307)	2.21767302
41	Prolonged partial thromboplastin time (HP:0003645)	2.21756603
42	Tongue fasciculations (HP:0001308)	2.21750278
43	Spontaneous abortion (HP:0005268)	2.17679645
44	Gonadal dysgenesis (HP:0000133)	2.11026246
45	Hyperbilirubinemia (HP:0002904)	2.09728739
46	Abnormality of cochlea (HP:0000375)	2.09016613
47	Myelomeningocele (HP:0002475)	2.08802981
48	Supernumerary ribs (HP:0005815)	2.06742350
49	Pigmentary retinal degeneration (HP:0001146)	2.06514996
50	Broad palm (HP:0001169)	1.99962182
51	Widely patent fontanelles and sutures (HP:0004492)	1.99223134
52	Oligodactyly (hands) (HP:0001180)	1.98563792
53	Astrocytoma (HP:0009592)	1.96940047
54	Abnormality of the astrocytes (HP:0100707)	1.96940047
55	Abnormality of glycolysis (HP:0004366)	1.93809729
56	Abnormality of reticulocytes (HP:0004312)	1.93645289
57	Periauricular skin pits (HP:0100277)	1.92310703
58	Preauricular pit (HP:0004467)	1.92310703
59	Excessive salivation (HP:0003781)	1.91640809
60	Pancreatic islet-cell hyperplasia (HP:0004510)	1.90691223
61	Hypochromic anemia (HP:0001931)	1.87462654
62	Hypomagnesemia (HP:0002917)	1.87287899
63	Delayed epiphyseal ossification (HP:0002663)	1.86977252
64	Microvesicular hepatic steatosis (HP:0001414)	1.86632218
65	Impaired smooth pursuit (HP:0007772)	1.86144940
66	Glioma (HP:0009733)	1.84295668
67	Abnormality of the pons (HP:0007361)	1.84251102
68	Muscle fibrillation (HP:0010546)	1.81313569
69	EMG: neuropathic changes (HP:0003445)	1.81129235
70	Oligodontia (HP:0000677)	1.79886850
71	Glycosuria (HP:0003076)	1.78342145
72	Abnormality of urine glucose concentration (HP:0011016)	1.78342145
73	Hyperglycinemia (HP:0002154)	1.77861322
74	Ependymoma (HP:0002888)	1.77581550
75	Tetany (HP:0001281)	1.76732632
76	Abolished electroretinogram (ERG) (HP:0000550)	1.76279334
77	Scanning speech (HP:0002168)	1.75252984
78	Supernumerary bones of the axial skeleton (HP:0009144)	1.73095148
79	Abnormality of the costochondral junction (HP:0000919)	1.70576983
80	Chromsome breakage (HP:0040012)	1.70245054
81	Myokymia (HP:0002411)	1.68756958
82	Areflexia of lower limbs (HP:0002522)	1.67776437
83	Stenosis of the external auditory canal (HP:0000402)	1.67602986
84	Rhabdomyosarcoma (HP:0002859)	1.66833461
85	Joint hemorrhage (HP:0005261)	1.66397517
86	Abnormality of the nasolacrimal system (HP:0000614)	1.66330687
87	Hypoproteinemia (HP:0003075)	1.65304164
88	Submucous cleft hard palate (HP:0000176)	1.63816969
89	Intellectual disability, moderate (HP:0002342)	1.63148310
90	Diastasis recti (HP:0001540)	1.62339674
91	Fat malabsorption (HP:0002630)	1.62303432
92	Central scotoma (HP:0000603)	1.62252699
93	Sudden death (HP:0001699)	1.61667959
94	Abnormal hemoglobin (HP:0011902)	1.60511201
95	Failure to thrive in infancy (HP:0001531)	1.60466107
96	Male infertility (HP:0003251)	1.59440268
97	Abnormality of ocular smooth pursuit (HP:0000617)	1.59424462
98	Thyroid carcinoma (HP:0002890)	1.56940264
99	Anteriorly placed anus (HP:0001545)	1.56485815
100	Generalized hypopigmentation of hair (HP:0011358)	1.55721902

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.17371156
2	NEK1	3.49943586
3	BLK	2.90026175
4	WNK4	2.82517025
5	CDC7	2.69526458
6	STK38L	2.64663960
7	PDK2	2.53906951
8	DYRK3	2.24271125
9	MAP3K2	2.19664120
10	NME1	1.91249438
11	GRK7	1.73376284
12	FGFR2	1.72777229
13	PIK3CA	1.68696584
14	EIF2AK1	1.66960160
15	EIF2AK2	1.54584690
16	PBK	1.51128834
17	TTK	1.51080184
18	NTRK3	1.50238864
19	STK39	1.46877344
20	ZAK	1.46622956
21	CCNB1	1.44655963
22	TYRO3	1.40114020
23	EPHA4	1.39799906
24	MAP3K4	1.36222133
25	LATS2	1.35163052
26	OBSCN	1.31941994
27	PIK3CG	1.31184498
28	LATS1	1.24294337
29	MAP3K7	1.18723713
30	FRK	1.17251238
31	MUSK	1.17178598
32	MAP2K7	1.12814340
33	WEE1	1.12190221
34	CDK4	1.09799736
35	TLK1	1.09541353
36	DMPK	1.09346319
37	TGFBR2	1.07847081
38	PLK3	1.07434328
39	WNK1	1.07094569
40	PRKCG	1.03203017
41	PLK1	1.02114822
42	EPHB2	1.00638157
43	ATR	0.99119986
44	EIF2AK3	0.98783745
45	FGFR1	0.97083402
46	CHEK2	0.93514590
47	TSSK6	0.93047753
48	ATM	0.86918813
49	FGFR3	0.85776512
50	MKNK2	0.83620832
51	PNCK	0.83215159
52	OXSR1	0.79325510
53	INSRR	0.77618603
54	DYRK1A	0.76987103
55	MAP3K10	0.76058893
56	MKNK1	0.75647461
57	DYRK1B	0.75221898
58	MST1R	0.74733168
59	CHEK1	0.72298962
60	PASK	0.71378974
61	NEK6	0.69300408
62	AURKB	0.68488605
63	TNIK	0.68295886
64	PLK2	0.66561561
65	PIM1	0.66529192
66	ACVR1B	0.65644010
67	PRKDC	0.65223157
68	PRKACA	0.64943705
69	RPS6KB1	0.64662125
70	TXK	0.64489395
71	GRK5	0.63998332
72	PRKACB	0.61590546
73	PRKG1	0.61505817
74	CDK1	0.59115281
75	CSNK2A1	0.59074065
76	SCYL2	0.58292883
77	STK16	0.58138365
78	RPS6KA3	0.57665403
79	CSNK2A2	0.57197378
80	CAMK4	0.56523991
81	AKT1	0.56202733
82	PRKACG	0.56162577
83	PRKAA1	0.54136998
84	NTRK2	0.53483014
85	CDK2	0.53276008
86	AURKA	0.53028130
87	STK3	0.50896205
88	GSK3B	0.48967047
89	MOS	0.48118846
90	CSNK1E	0.47911492
91	RPS6KA6	0.46584737
92	CDK8	0.45696844
93	TAOK3	0.45263362
94	CAMK2A	0.43629405
95	MARK3	0.43417066
96	RPS6KL1	0.43008369
97	RPS6KC1	0.43008369
98	FGFR4	0.42176374
99	SRPK1	0.39954181
100	STK38	0.39751870

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.96148989
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.65191763
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.60916940
4	Ribosome_Homo sapiens_hsa03010	2.57816037
5	Nicotine addiction_Homo sapiens_hsa05033	2.48837015
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.42872019
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.38315840
8	One carbon pool by folate_Homo sapiens_hsa00670	2.29833402
9	Mismatch repair_Homo sapiens_hsa03430	2.17519048
10	Fatty acid metabolism_Homo sapiens_hsa01212	2.14043873
11	Fatty acid degradation_Homo sapiens_hsa00071	1.99116542
12	Butanoate metabolism_Homo sapiens_hsa00650	1.85417894
13	Fat digestion and absorption_Homo sapiens_hsa04975	1.83638085
14	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.82558408
15	mRNA surveillance pathway_Homo sapiens_hsa03015	1.81201619
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.79486875
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.78549028
18	RNA transport_Homo sapiens_hsa03013	1.70992260
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.69948557
20	DNA replication_Homo sapiens_hsa03030	1.68194335
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.67618105
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.62219205
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.61955719
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.61031893
25	Homologous recombination_Homo sapiens_hsa03440	1.60634073
26	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.58178477
27	Propanoate metabolism_Homo sapiens_hsa00640	1.41034262
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40837628
29	Complement and coagulation cascades_Homo sapiens_hsa04610	1.40223488
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.38692773
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37410965
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30654025
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29213246
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28573260
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25959660
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22690589
37	RNA degradation_Homo sapiens_hsa03018	1.21033275
38	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17817834
39	Retinol metabolism_Homo sapiens_hsa00830	1.13518862
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13422335
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01913425
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01550639
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96758275
44	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93788937
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91972577
46	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.89210164
47	Purine metabolism_Homo sapiens_hsa00230	0.88525311
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86437932
49	Basal transcription factors_Homo sapiens_hsa03022	0.85613720
50	Morphine addiction_Homo sapiens_hsa05032	0.85367233
51	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.84163640
52	Circadian rhythm_Homo sapiens_hsa04710	0.84030814
53	Protein export_Homo sapiens_hsa03060	0.83977929
54	Cell cycle_Homo sapiens_hsa04110	0.83108082
55	Asthma_Homo sapiens_hsa05310	0.80269667
56	Renin secretion_Homo sapiens_hsa04924	0.80036596
57	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.78482234
58	Spliceosome_Homo sapiens_hsa03040	0.77650167
59	Folate biosynthesis_Homo sapiens_hsa00790	0.75780872
60	ABC transporters_Homo sapiens_hsa02010	0.72936702
61	Taste transduction_Homo sapiens_hsa04742	0.71948213
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70883181
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68874751
64	Parkinsons disease_Homo sapiens_hsa05012	0.68637890
65	Phenylalanine metabolism_Homo sapiens_hsa00360	0.66605645
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.66394325
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65597466
68	Peroxisome_Homo sapiens_hsa04146	0.65441447
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64654755
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.64179006
71	Oocyte meiosis_Homo sapiens_hsa04114	0.64113110
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62239302
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.61674846
74	GABAergic synapse_Homo sapiens_hsa04727	0.58806224
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.58244069
76	Base excision repair_Homo sapiens_hsa03410	0.57785682
77	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.57701819
78	Huntingtons disease_Homo sapiens_hsa05016	0.57316367
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57192662
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.57026684
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56209275
82	Galactose metabolism_Homo sapiens_hsa00052	0.55131962
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55083173
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54358429
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53845035
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53399285
87	Bile secretion_Homo sapiens_hsa04976	0.52195302
88	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51691804
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50889428
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49134815
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.46731583
92	Proteasome_Homo sapiens_hsa03050	0.45343489
93	Insulin resistance_Homo sapiens_hsa04931	0.44153587
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.43213378
95	Carbon metabolism_Homo sapiens_hsa01200	0.38438570
96	Metabolic pathways_Homo sapiens_hsa01100	0.37990720
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.37984425
98	AMPK signaling pathway_Homo sapiens_hsa04152	0.37423535
99	Alcoholism_Homo sapiens_hsa05034	0.35876320
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35458742

CTAGE3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »