ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	7.23984919
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	7.10823568
3	regulation of water loss via skin (GO:0033561)	6.41854518
4	establishment of skin barrier (GO:0061436)	6.22760696
5	hemidesmosome assembly (GO:0031581)	5.21873758
6	maintenance of gastrointestinal epithelium (GO:0030277)	5.12370068
7	multicellular organismal water homeostasis (GO:0050891)	4.63966036
8	intestinal epithelial cell development (GO:0060576)	4.30309863
9	keratinocyte proliferation (GO:0043616)	4.09608221
10	nucleotide-sugar biosynthetic process (GO:0009226)	4.08509680
11	cellular glucuronidation (GO:0052695)	4.06681001
12	glucuronate metabolic process (GO:0019585)	4.06388116
13	uronic acid metabolic process (GO:0006063)	4.06388116
14	O-glycan processing (GO:0016266)	4.04121997
15	epithelial structure maintenance (GO:0010669)	3.98811316
16	negative regulation of keratinocyte proliferation (GO:0010839)	3.92841900
17	water homeostasis (GO:0030104)	3.90046926
18	tight junction assembly (GO:0070830)	3.84700962
19	gap junction assembly (GO:0016264)	3.61319806
20	regulation of bile acid biosynthetic process (GO:0070857)	3.56861462
21	nuclear pore complex assembly (GO:0051292)	3.45359964
22	regulation of transforming growth factor beta1 production (GO:0032908)	3.37899750
23	cellular response to epidermal growth factor stimulus (GO:0071364)	3.37845596
24	keratinization (GO:0031424)	3.36587139
25	regulation of podosome assembly (GO:0071801)	3.35779184
26	ribosome assembly (GO:0042255)	3.35679592
27	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.28814068
28	nuclear pore organization (GO:0006999)	3.27218581
29	keratinocyte development (GO:0003334)	3.17547295
30	urea metabolic process (GO:0019627)	3.17438462
31	urea cycle (GO:0000050)	3.15352735
32	epithelial cell-cell adhesion (GO:0090136)	3.13859620
33	skin morphogenesis (GO:0043589)	3.12781907
34	keratinocyte differentiation (GO:0030216)	3.04063334
35	cell-cell junction assembly (GO:0007043)	2.98280661
36	mitotic sister chromatid cohesion (GO:0007064)	2.95241503
37	glomerular visceral epithelial cell development (GO:0072015)	2.87581393
38	regulation of G0 to G1 transition (GO:0070316)	2.84850981
39	positive regulation of macroautophagy (GO:0016239)	2.82103170
40	ER overload response (GO:0006983)	2.79936474
41	COPII vesicle coating (GO:0048208)	2.78922418
42	regulation of keratinocyte proliferation (GO:0010837)	2.77150479
43	epidermal cell differentiation (GO:0009913)	2.76037044
44	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.75145426
45	GDP-mannose metabolic process (GO:0019673)	2.75011511
46	phosphate ion transmembrane transport (GO:0035435)	2.73690726
47	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.73194183
48	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.70551229
49	regulation of keratinocyte differentiation (GO:0045616)	2.70429901
50	positive regulation of epidermal cell differentiation (GO:0045606)	2.67530043
51	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	2.64627460
52	L-serine metabolic process (GO:0006563)	2.64101874
53	protein complex localization (GO:0031503)	2.62663601
54	surfactant homeostasis (GO:0043129)	2.61027251
55	Leydig cell differentiation (GO:0033327)	2.60000421
56	chemical homeostasis within a tissue (GO:0048875)	2.57899733
57	protein O-linked glycosylation (GO:0006493)	2.57637235
58	histone H3-K9 demethylation (GO:0033169)	2.57183540
59	response to epidermal growth factor (GO:0070849)	2.56833237
60	nitrogen cycle metabolic process (GO:0071941)	2.56588930
61	mammary gland alveolus development (GO:0060749)	2.56297929
62	regulation of cholesterol homeostasis (GO:2000188)	2.54762897
63	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.54225322
64	regulation of transforming growth factor beta production (GO:0071634)	2.53946153
65	serine family amino acid biosynthetic process (GO:0009070)	2.52437444
66	glomerular epithelial cell development (GO:0072310)	2.52120024
67	muscle atrophy (GO:0014889)	2.51835485
68	RNA-dependent DNA replication (GO:0006278)	2.51246457
69	histone H3-K36 demethylation (GO:0070544)	2.49961087
70	endothelial cell morphogenesis (GO:0001886)	2.48347129
71	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.46588909
72	regulation of transforming growth factor beta2 production (GO:0032909)	2.43633497
73	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.43379974
74	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.42905233
75	sphingomyelin metabolic process (GO:0006684)	2.42209304
76	membrane budding (GO:0006900)	2.40799926
77	positive regulation of keratinocyte differentiation (GO:0045618)	2.39955293
78	phosphate ion homeostasis (GO:0055062)	2.38859018
79	trivalent inorganic anion homeostasis (GO:0072506)	2.38859018
80	biotin metabolic process (GO:0006768)	2.38707329
81	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	2.38132727
82	epidermis development (GO:0008544)	2.37650243
83	protein targeting to Golgi (GO:0000042)	2.37390369
84	cellular protein complex localization (GO:0034629)	2.35905475
85	mammary gland epithelial cell proliferation (GO:0033598)	2.35712616
86	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.34620204
87	COPI coating of Golgi vesicle (GO:0048205)	2.33357132
88	Golgi transport vesicle coating (GO:0048200)	2.33357132
89	protein autoprocessing (GO:0016540)	2.32585733
90	response to vitamin A (GO:0033189)	2.30505190
91	hippo signaling (GO:0035329)	2.28423712
92	regulation of helicase activity (GO:0051095)	2.27156593
93	pore complex assembly (GO:0046931)	2.26839482
94	regulation of endothelial cell chemotaxis (GO:2001026)	2.26572555
95	receptor recycling (GO:0001881)	2.26506303
96	establishment of apical/basal cell polarity (GO:0035089)	2.25530039
97	striated muscle atrophy (GO:0014891)	2.24892424
98	phosphate ion transport (GO:0006817)	2.24512199
99	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.24334658
100	positive regulation of epidermis development (GO:0045684)	2.23678221

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	6.58760646
2	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	4.51252383
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.92257184
4	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.64016109
5	AR_21909140_ChIP-Seq_LNCAP_Human	2.99487922
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.92645941
7	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.84774669
8	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.84774669
9	GATA6_25053715_ChIP-Seq_YYC3_Human	2.74311878
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.68238905
11	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	2.66479357
12	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.53744865
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.42487275
14	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.39235025
15	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	2.35873853
16	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.32705248
17	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.22906299
18	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.21855564
19	PPAR_26484153_Chip-Seq_NCI-H1993_Human	2.09439716
20	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	2.08126910
21	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	2.02492120
22	SOX2_20726797_ChIP-Seq_SW620_Human	2.01214756
23	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.00553830
24	GATA4_25053715_ChIP-Seq_YYC3_Human	2.00300805
25	ATF3_27146783_Chip-Seq_COLON_Human	1.94833537
26	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.90055091
27	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.87342095
28	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.85388683
29	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.84131627
30	RACK7_27058665_Chip-Seq_MCF-7_Human	1.83987364
31	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.82228827
32	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.77379590
33	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.75699088
34	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.74392938
35	CHD1_26751641_Chip-Seq_LNCaP_Human	1.74256313
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.73172938
37	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.72830102
38	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.69133367
39	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.67898395
40	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.66203917
41	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.64084051
42	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.61462925
43	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.59427571
44	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.55477517
45	ELF5_23300383_ChIP-Seq_T47D_Human	1.54802668
46	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.52904255
47	KLF5_25053715_ChIP-Seq_YYC3_Human	1.46727677
48	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.46241789
49	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.43768644
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.40725164
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40412570
52	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.36320949
53	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.32570049
54	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.30784172
55	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.30373193
56	ZNF263_19887448_ChIP-Seq_K562_Human	1.29487148
57	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29140412
58	CJUN_26792858_Chip-Seq_BT549_Human	1.28158074
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24401384
60	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21443898
61	TP63_23658742_ChIP-Seq_EP156T_Human	1.21136231
62	CLOCK_20551151_ChIP-Seq_293T_Human	1.17589993
63	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.14508122
64	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.13686916
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.09792044
66	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.08233770
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.07891211
68	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.06862336
69	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06758626
70	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06731518
71	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.06361337
72	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.04888910
73	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.04667634
74	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.03240990
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01941968
76	* UBF1/2_26484160_Chip-Seq_HMECs_Human	0.99910240
77	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.99663669
78	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.98340854
79	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.96498708
80	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.96405285
81	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95094758
82	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.94119356
83	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.94092469
84	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.93972400
85	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.92319606
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91879126
87	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.91009368
88	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89781977
89	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.88847574
90	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.86979352
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86209589
92	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.85507803
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.84335300
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.84250104
95	BRD4_25478319_ChIP-Seq_HGPS_Human	0.83023292
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.81594353
97	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.81119124
98	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.80200605
99	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.80120195
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.79752243

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.09765329
2	MP0002796_impaired_skin_barrier	4.17127878
3	MP0003941_abnormal_skin_development	3.77058165
4	MP0000579_abnormal_nail_morphology	3.39118111
5	MP0010678_abnormal_skin_adnexa	2.99699399
6	MP0010352_gastrointestinal_tract_polyps	2.83874479
7	MP0004264_abnormal_extraembryonic_tissu	2.79766401
8	MP0008057_abnormal_DNA_replication	2.60047368
9	MP0005501_abnormal_skin_physiology	2.47978985
10	MP0002139_abnormal_hepatobiliary_system	2.28723006
11	MP0003705_abnormal_hypodermis_morpholog	2.26232223
12	MP0005275_abnormal_skin_tensile	2.24896085
13	MP0002060_abnormal_skin_morphology	2.22854935
14	MP0001666_abnormal_nutrient_absorption	2.17656008
15	MP0002098_abnormal_vibrissa_morphology	2.14006368
16	MP0000383_abnormal_hair_follicle	2.07580767
17	MP0001216_abnormal_epidermal_layer	2.07459324
18	MP0002138_abnormal_hepatobiliary_system	2.04271721
19	MP0003693_abnormal_embryo_hatching	2.01646806
20	MP0003453_abnormal_keratinocyte_physiol	2.00313898
21	MP0009697_abnormal_copulation	1.85958066
22	MP0004272_abnormal_basement_membrane	1.85218005
23	MP0003950_abnormal_plasma_membrane	1.85216667
24	MP0003252_abnormal_bile_duct	1.84433216
25	MP0004782_abnormal_surfactant_physiolog	1.84001831
26	MP0004043_abnormal_pH_regulation	1.75219532
27	MP0003566_abnormal_cell_adhesion	1.72530668
28	MP0004957_abnormal_blastocyst_morpholog	1.72389504
29	MP0000762_abnormal_tongue_morphology	1.67665072
30	MP0005085_abnormal_gallbladder_physiolo	1.63405405
31	MP0001849_ear_inflammation	1.61117024
32	MP0000377_abnormal_hair_follicle	1.57139474
33	MP0010771_integument_phenotype	1.56056881
34	MP0005365_abnormal_bile_salt	1.45812213
35	MP0003806_abnormal_nucleotide_metabolis	1.44849412
36	MP0001661_extended_life_span	1.43666467
37	MP0003868_abnormal_feces_composition	1.42226262
38	MP0005360_urolithiasis	1.41004705
39	MP0002254_reproductive_system_inflammat	1.38483753
40	MP0000427_abnormal_hair_cycle	1.37943454
41	MP0005023_abnormal_wound_healing	1.37178811
42	MP0000467_abnormal_esophagus_morphology	1.33317315
43	MP0000627_abnormal_mammary_gland	1.29442002
44	MP0004019_abnormal_vitamin_homeostasis	1.28219853
45	MP0003183_abnormal_peptide_metabolism	1.25685330
46	MP0000566_synostosis	1.23283950
47	MP0001730_embryonic_growth_arrest	1.22609465
48	MP0001881_abnormal_mammary_gland	1.20847070
49	MP0003195_calcinosis	1.18738916
50	MP0000678_abnormal_parathyroid_gland	1.08809573
51	MP0005332_abnormal_amino_acid	1.08749759
52	MP0000647_abnormal_sebaceous_gland	1.08120581
53	MP0009931_abnormal_skin_appearance	1.03676809
54	MP0003718_maternal_effect	1.01297788
55	MP0005451_abnormal_body_composition	1.01124380
56	MP0005083_abnormal_biliary_tract	1.01061152
57	MP0005408_hypopigmentation	1.00087337
58	MP0003111_abnormal_nucleus_morphology	0.97751303
59	MP0005076_abnormal_cell_differentiation	0.97627716
60	MP0001873_stomach_inflammation	0.97579230
61	MP0003786_premature_aging	0.95693135
62	MP0009672_abnormal_birth_weight	0.94255161
63	MP0010094_abnormal_chromosome_stability	0.92139733
64	MP0008058_abnormal_DNA_repair	0.91152471
65	MP0003077_abnormal_cell_cycle	0.90365776
66	MP0004947_skin_inflammation	0.86584984
67	MP0002876_abnormal_thyroid_physiology	0.85264525
68	MP0002697_abnormal_eye_size	0.84313039
69	MP0002086_abnormal_extraembryonic_tissu	0.84154902
70	MP0005395_other_phenotype	0.83560009
71	MP0008932_abnormal_embryonic_tissue	0.83324195
72	MP0000537_abnormal_urethra_morphology	0.82305339
73	MP0000462_abnormal_digestive_system	0.81835378
74	MP0001191_abnormal_skin_condition	0.81581760
75	MP0000470_abnormal_stomach_morphology	0.81558112
76	MP0000367_abnormal_coat/_hair	0.80313895
77	MP0003890_abnormal_embryonic-extraembry	0.79941776
78	MP0000350_abnormal_cell_proliferation	0.79799460
79	MP0003943_abnormal_hepatobiliary_system	0.79715686
80	MP0009643_abnormal_urine_homeostasis	0.78761299
81	MP0008875_abnormal_xenobiotic_pharmacok	0.78339912
82	MP0001765_abnormal_ion_homeostasis	0.77582695
83	MP0000003_abnormal_adipose_tissue	0.77270109
84	MP0004185_abnormal_adipocyte_glucose	0.75171449
85	MP0009703_decreased_birth_body	0.74257662
86	MP0003191_abnormal_cellular_cholesterol	0.72251404
87	MP0004233_abnormal_muscle_weight	0.71149198
88	MP0003984_embryonic_growth_retardation	0.70829831
89	MP0000477_abnormal_intestine_morphology	0.69936429
90	MP0003091_abnormal_cell_migration	0.69375594
91	MP0010030_abnormal_orbit_morphology	0.68909043
92	MP0001243_abnormal_dermal_layer	0.68782711
93	MP0005380_embryogenesis_phenotype	0.68405201
94	MP0001672_abnormal_embryogenesis/_devel	0.68405201
95	MP0010386_abnormal_urinary_bladder	0.68045607
96	MP0002088_abnormal_embryonic_growth/wei	0.67431455
97	MP0005257_abnormal_intraocular_pressure	0.65382479
98	MP0003937_abnormal_limbs/digits/tail_de	0.65007876
99	MP0002084_abnormal_developmental_patter	0.64504871
100	MP0000432_abnormal_head_morphology	0.64271062

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	6.47230576
2	Right ventricular cardiomyopathy (HP:0011663)	5.66180945
3	Abnormal hair laboratory examination (HP:0003328)	4.78382378
4	Lip pit (HP:0100267)	4.19108507
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.84374953
6	Sparse eyelashes (HP:0000653)	3.60006175
7	Intrahepatic cholestasis (HP:0001406)	3.58409577
8	Milia (HP:0001056)	3.58016740
9	Hyperactive renin-angiotensin system (HP:0000841)	3.41611541
10	Onycholysis (HP:0001806)	3.34608471
11	Malnutrition (HP:0004395)	3.33875301
12	Plantar hyperkeratosis (HP:0007556)	3.32941435
13	Abnormality of nail color (HP:0100643)	3.25428346
14	Alopecia of scalp (HP:0002293)	3.21050289
15	Chronic bronchitis (HP:0004469)	3.18521353
16	Conjugated hyperbilirubinemia (HP:0002908)	3.10270860
17	Abnormality of the nasal septum (HP:0000419)	2.95741962
18	Hypophosphatemic rickets (HP:0004912)	2.91278917
19	Palmar hyperkeratosis (HP:0010765)	2.86427707
20	Palmoplantar hyperkeratosis (HP:0000972)	2.85723006
21	Hyperkalemia (HP:0002153)	2.84445601
22	Sparse lateral eyebrow (HP:0005338)	2.72946735
23	Fragile nails (HP:0001808)	2.72469253
24	Pterygium (HP:0001059)	2.72241078
25	Congenital ichthyosiform erythroderma (HP:0007431)	2.63715117
26	Atrophic scars (HP:0001075)	2.62295307
27	Abnormality of chloride homeostasis (HP:0011422)	2.60521214
28	Woolly hair (HP:0002224)	2.58967070
29	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.55666659
30	Rickets (HP:0002748)	2.51992044
31	Hypotrichosis (HP:0001006)	2.49540233
32	Tetraparesis (HP:0002273)	2.44242249
33	Popliteal pterygium (HP:0009756)	2.38992137
34	Trismus (HP:0000211)	2.38739271
35	Abnormality of the salivary glands (HP:0010286)	2.33959190
36	Abnormality of the gastric mucosa (HP:0004295)	2.33645078
37	Biliary tract neoplasm (HP:0100574)	2.29796228
38	Short nail (HP:0001799)	2.28952487
39	Abnormality of the distal phalanges of the toes (HP:0010182)	2.27630761
40	Vascular calcification (HP:0004934)	2.27263099
41	Natal tooth (HP:0000695)	2.27081326
42	Hypoplasia of dental enamel (HP:0006297)	2.25075697
43	Advanced eruption of teeth (HP:0006288)	2.21104483
44	Ependymoma (HP:0002888)	2.16427815
45	Depressed nasal tip (HP:0000437)	2.12598110
46	Curly hair (HP:0002212)	2.11603416
47	Dehydration (HP:0001944)	2.09247143
48	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.08865993
49	Hypoplastic labia majora (HP:0000059)	2.07289362
50	Villous atrophy (HP:0011473)	2.05867566
51	Abnormality of small intestinal villus morphology (HP:0011472)	2.05867566
52	Selective tooth agenesis (HP:0001592)	2.05340890
53	Hydroxyprolinuria (HP:0003080)	2.05259588
54	Abnormality of proline metabolism (HP:0010907)	2.05259588
55	Fragile skin (HP:0001030)	2.03132006
56	Abnormality of the dental pulp (HP:0006479)	2.00716305
57	Broad face (HP:0000283)	2.00671334
58	Focal segmental glomerulosclerosis (HP:0000097)	1.99055226
59	Nail dystrophy (HP:0008404)	1.98437948
60	Flat acetabular roof (HP:0003180)	1.97444623
61	Corneal erosion (HP:0200020)	1.97120891
62	Chromsome breakage (HP:0040012)	1.96922326
63	Cardiovascular calcification (HP:0011915)	1.96423244
64	Follicular hyperkeratosis (HP:0007502)	1.95482406
65	Thin bony cortex (HP:0002753)	1.95468981
66	Abnormality of the labia majora (HP:0012881)	1.92691307
67	Multiple enchondromatosis (HP:0005701)	1.88819844
68	Abnormality of pyrimidine metabolism (HP:0004353)	1.87625909
69	Aplasia cutis congenita (HP:0001057)	1.84805501
70	Hyponatremia (HP:0002902)	1.84573182
71	Ankyloglossia (HP:0010296)	1.84557305
72	Absent eyelashes (HP:0000561)	1.83629882
73	Glomerulosclerosis (HP:0000096)	1.81957115
74	Abnormality of the dental root (HP:0006486)	1.81714764
75	Taurodontia (HP:0000679)	1.81714764
76	Abnormality of permanent molar morphology (HP:0011071)	1.81714764
77	Ureteral duplication (HP:0000073)	1.81509104
78	Abnormal biliary tract morphology (HP:0012440)	1.80189384
79	Ectropion (HP:0000656)	1.79603095
80	Abnormality of the costochondral junction (HP:0000919)	1.79495935
81	Rhabdomyosarcoma (HP:0002859)	1.77951377
82	Abnormality of the preputium (HP:0100587)	1.77390240
83	Fat malabsorption (HP:0002630)	1.74696059
84	Ridged nail (HP:0001807)	1.70374660
85	Abnormality of molar (HP:0011077)	1.70118822
86	Abnormality of molar morphology (HP:0011070)	1.70118822
87	Oral leukoplakia (HP:0002745)	1.68134090
88	Male infertility (HP:0003251)	1.67004629
89	Abnormality of the astrocytes (HP:0100707)	1.66847243
90	Astrocytoma (HP:0009592)	1.66847243
91	Amelogenesis imperfecta (HP:0000705)	1.66372405
92	Duplicated collecting system (HP:0000081)	1.66274624
93	Abnormal trabecular bone morphology (HP:0100671)	1.65707870
94	Distal upper limb amyotrophy (HP:0007149)	1.65459108
95	Upper limb amyotrophy (HP:0009129)	1.65459108
96	Dry hair (HP:0011359)	1.65274793
97	Urethral obstruction (HP:0000796)	1.63875529
98	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.63590185
99	Abnormal cartilage morphology (HP:0002763)	1.63570481
100	Osteolytic defects of the hand bones (HP:0009699)	1.62788549

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	7.93327207
2	EPHA2	4.55037319
3	MET	4.01641619
4	MST4	3.57529614
5	STK24	3.48677518
6	WNK4	2.65949101
7	NME1	2.54202783
8	MAP3K12	2.30197467
9	STK38L	2.27599579
10	TSSK6	2.21878196
11	PBK	2.08301372
12	STK39	2.03722793
13	TNIK	1.65433755
14	LMTK2	1.64105309
15	LATS1	1.64005793
16	SIK3	1.61239633
17	BRSK2	1.59928979
18	TTK	1.56295933
19	CDK12	1.56041157
20	PAK4	1.50766496
21	TRIM28	1.38346250
22	OXSR1	1.33935900
23	PTK2	1.32995160
24	TAF1	1.31948397
25	BCR	1.21485473
26	WNK1	1.18960693
27	EIF2AK1	1.18950133
28	MAP3K9	1.16370353
29	SIK1	1.14211288
30	MKNK2	1.08992382
31	MYLK	1.06974750
32	EIF2AK3	1.06235032
33	FER	1.05795531
34	STK3	1.04155536
35	ACVR1B	1.03313308
36	MAP3K2	1.02690036
37	SRPK1	1.02635002
38	PRKG2	0.99088425
39	MAP3K3	0.95028838
40	CAMK1D	0.93062624
41	MAP3K13	0.88432396
42	RIPK1	0.87715148
43	AKT3	0.87452248
44	CAMK1G	0.83930339
45	LATS2	0.82130112
46	YES1	0.74498627
47	SMG1	0.73590272
48	ERBB4	0.70664715
49	MKNK1	0.66782658
50	TESK1	0.63614127
51	RPS6KB2	0.63520848
52	MELK	0.63451917
53	NEK1	0.62653575
54	MAP2K6	0.61368246
55	PRKCI	0.58280484
56	BMX	0.56104260
57	MTOR	0.53902201
58	FGFR1	0.51894225
59	BUB1	0.49231720
60	PDGFRB	0.48234299
61	DAPK1	0.47341312
62	STK10	0.46321803
63	WEE1	0.45036700
64	MAP3K6	0.44676308
65	PDGFRA	0.43058237
66	TRPM7	0.40495112
67	PTK6	0.39419493
68	GRK1	0.39409223
69	ARAF	0.39210260
70	PIK3CA	0.37783769
71	MAPKAPK3	0.36407344
72	NLK	0.36208697
73	STK38	0.35776971
74	CSNK1E	0.35705687
75	CDK9	0.35120486
76	BMPR1B	0.34214155
77	CDK7	0.33267510
78	CHEK1	0.32818654
79	NME2	0.30079989
80	TGFBR1	0.28387333
81	BRSK1	0.28196539
82	AURKB	0.26466107
83	IRAK3	0.25838674
84	MAPK15	0.25667673
85	NEK6	0.24849852
86	CDK3	0.24678412
87	PRKCE	0.23743366
88	ATM	0.22959818
89	MAP3K10	0.22896219
90	BRAF	0.22808941
91	PLK1	0.22285560
92	PAK2	0.21942809
93	CASK	0.21897615
94	PRKD2	0.20651391
95	MUSK	0.20647489
96	ERBB2	0.20452792
97	FGFR4	0.19959869
98	MAPKAPK2	0.19071076
99	PRKAA2	0.17999123
100	VRK2	0.17746747

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.32384711
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.03458664
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.83732934
4	Sulfur metabolism_Homo sapiens_hsa00920	2.35889672
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.12853500
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.11682900
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.10519099
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.09087128
9	Retinol metabolism_Homo sapiens_hsa00830	2.03221294
10	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.96638602
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93424049
12	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.90210075
13	Caffeine metabolism_Homo sapiens_hsa00232	1.88846737
14	Adherens junction_Homo sapiens_hsa04520	1.87790449
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.87066069
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83572124
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.83423306
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.82113680
19	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.81319040
20	Thyroid cancer_Homo sapiens_hsa05216	1.80510669
21	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.72036296
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.63686590
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.63522578
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.58452766
25	Tight junction_Homo sapiens_hsa04530	1.56174458
26	Proteasome_Homo sapiens_hsa03050	1.49114755
27	Glutathione metabolism_Homo sapiens_hsa00480	1.45799628
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.45002453
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.44374844
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.43764977
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.41317956
32	Phenylalanine metabolism_Homo sapiens_hsa00360	1.39177445
33	Histidine metabolism_Homo sapiens_hsa00340	1.35637588
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.23882704
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.20141685
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.20009888
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19961109
38	RNA transport_Homo sapiens_hsa03013	1.13684817
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.13608749
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.13215591
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13038435
42	Galactose metabolism_Homo sapiens_hsa00052	1.12642596
43	Lysine degradation_Homo sapiens_hsa00310	1.10911644
44	Bile secretion_Homo sapiens_hsa04976	1.10073313
45	Mismatch repair_Homo sapiens_hsa03430	1.04681697
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00328407
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.97452910
48	ECM-receptor interaction_Homo sapiens_hsa04512	0.95932703
49	Folate biosynthesis_Homo sapiens_hsa00790	0.87078036
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.84933183
51	Complement and coagulation cascades_Homo sapiens_hsa04610	0.84152910
52	Oocyte meiosis_Homo sapiens_hsa04114	0.83403903
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83084122
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81884667
55	Circadian rhythm_Homo sapiens_hsa04710	0.79968659
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79918172
57	Vibrio cholerae infection_Homo sapiens_hsa05110	0.76904045
58	Mineral absorption_Homo sapiens_hsa04978	0.76390593
59	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72996996
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72952226
61	Fatty acid degradation_Homo sapiens_hsa00071	0.72363370
62	Tyrosine metabolism_Homo sapiens_hsa00350	0.71614298
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.70305061
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70298603
65	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.66025064
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.65353545
67	One carbon pool by folate_Homo sapiens_hsa00670	0.65245241
68	Carbon metabolism_Homo sapiens_hsa01200	0.63907069
69	ABC transporters_Homo sapiens_hsa02010	0.63467635
70	Amoebiasis_Homo sapiens_hsa05146	0.61808765
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60215186
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.57808487
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.57292155
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.56300079
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.55853206
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54002418
77	Pancreatic secretion_Homo sapiens_hsa04972	0.53151108
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53087075
79	DNA replication_Homo sapiens_hsa03030	0.52757778
80	Prostate cancer_Homo sapiens_hsa05215	0.51614408
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48690037
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47510290
83	Peroxisome_Homo sapiens_hsa04146	0.47228948
84	Renin-angiotensin system_Homo sapiens_hsa04614	0.46897972
85	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.46767469
86	Metabolic pathways_Homo sapiens_hsa01100	0.46391214
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46367211
88	Hepatitis C_Homo sapiens_hsa05160	0.46192586
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45805752
90	Base excision repair_Homo sapiens_hsa03410	0.45103880
91	RNA polymerase_Homo sapiens_hsa03020	0.44291898
92	Basal transcription factors_Homo sapiens_hsa03022	0.44043598
93	p53 signaling pathway_Homo sapiens_hsa04115	0.43713167
94	Small cell lung cancer_Homo sapiens_hsa05222	0.42200321
95	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42158335
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40994706
97	Proteoglycans in cancer_Homo sapiens_hsa05205	0.40143950
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39438847
99	Insulin resistance_Homo sapiens_hsa04931	0.38895375
100	Focal adhesion_Homo sapiens_hsa04510	0.38543183

CTAGE4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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