CTAGE6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.68178289
2response to pheromone (GO:0019236)7.79342564
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.72615827
4plasma membrane fusion (GO:0045026)7.70241124
5sperm motility (GO:0030317)7.36807406
6spermatid nucleus differentiation (GO:0007289)6.83703125
7chromosome condensation (GO:0030261)6.55901009
8DNA packaging (GO:0006323)6.25521528
9single strand break repair (GO:0000012)6.18131144
10sperm-egg recognition (GO:0035036)6.04970172
11binding of sperm to zona pellucida (GO:0007339)5.88329530
12establishment of protein localization to Golgi (GO:0072600)5.80042551
13negative regulation of inclusion body assembly (GO:0090084)5.75853282
14protein targeting to Golgi (GO:0000042)5.56891655
15microtubule depolymerization (GO:0007019)5.49697283
16sperm capacitation (GO:0048240)5.31149752
17retrograde transport, vesicle recycling within Golgi (GO:0000301)5.27464878
18multicellular organism reproduction (GO:0032504)5.22425882
19cell-cell recognition (GO:0009988)5.18987476
20calcium ion-dependent exocytosis (GO:0017156)5.05670921
21reproduction (GO:0000003)4.95918623
22sexual reproduction (GO:0019953)4.95667051
23spermatid development (GO:0007286)4.90120394
24mesonephros development (GO:0001823)4.89536753
25glycerol ether metabolic process (GO:0006662)4.83712479
26regulation of Rab GTPase activity (GO:0032313)4.70086196
27positive regulation of Rab GTPase activity (GO:0032851)4.70086196
28cellular ketone body metabolic process (GO:0046950)4.56534252
29histone H3-K36 demethylation (GO:0070544)4.54643717
30negative regulation of cAMP-mediated signaling (GO:0043951)4.50506443
31glomerular visceral epithelial cell development (GO:0072015)4.47980318
32ether metabolic process (GO:0018904)4.46503438
33nucleus organization (GO:0006997)4.38593405
34protein localization to Golgi apparatus (GO:0034067)4.09010430
35spermatogenesis (GO:0007283)4.07273698
36glomerular epithelial cell development (GO:0072310)4.06702485
37male gamete generation (GO:0048232)4.05580147
38phosphatidylethanolamine biosynthetic process (GO:0006646)4.02194637
39microtubule polymerization or depolymerization (GO:0031109)4.00774682
40ketone body metabolic process (GO:1902224)3.96192933
41peptidyl-proline hydroxylation (GO:0019511)3.86326935
42phosphatidylethanolamine metabolic process (GO:0046337)3.84313001
43gamete generation (GO:0007276)3.68318819
44coenzyme catabolic process (GO:0009109)3.66004331
45protein hydroxylation (GO:0018126)3.63993257
46mesenchymal cell differentiation involved in renal system development (GO:2001012)3.63015129
47mesenchymal cell differentiation involved in kidney development (GO:0072161)3.63015129
48regulation of gamma-delta T cell differentiation (GO:0045586)3.62895642
49cell differentiation involved in metanephros development (GO:0072202)3.53813221
50cell wall macromolecule catabolic process (GO:0016998)3.49933331
51regulation of gamma-delta T cell activation (GO:0046643)3.45049792
52regulation of histone H3-K27 methylation (GO:0061085)3.42489417
53ventricular system development (GO:0021591)3.41280458
54Golgi to endosome transport (GO:0006895)3.37212387
55negative regulation of Rho protein signal transduction (GO:0035024)3.35917586
56positive regulation of granulocyte differentiation (GO:0030854)3.30787412
57histone mRNA catabolic process (GO:0071044)3.28516985
58centriole replication (GO:0007099)3.27085087
59chromatin silencing (GO:0006342)3.21618176
60rRNA methylation (GO:0031167)3.20670007
61cilium or flagellum-dependent cell motility (GO:0001539)3.19541439
62epithelial cilium movement (GO:0003351)3.18908865
63positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18410793
64single fertilization (GO:0007338)3.15347230
65regulation of transcription involved in cell fate commitment (GO:0060850)3.08094816
66cell wall macromolecule metabolic process (GO:0044036)3.02520297
67axonemal dynein complex assembly (GO:0070286)3.02169766
68regulation of inclusion body assembly (GO:0090083)2.98622804
69interleukin-6-mediated signaling pathway (GO:0070102)2.98542047
70protein polyglutamylation (GO:0018095)2.96473050
71regulation of cilium movement (GO:0003352)2.96273271
72multicellular organismal reproductive process (GO:0048609)2.95552833
73nuclear pore complex assembly (GO:0051292)2.95348577
74aldehyde catabolic process (GO:0046185)2.93890549
75motile cilium assembly (GO:0044458)2.92849030
76regulation of T cell mediated cytotoxicity (GO:0001914)2.92741430
77intra-Golgi vesicle-mediated transport (GO:0006891)2.90432369
78regulation of T-helper 2 cell differentiation (GO:0045628)2.83484703
79NAD biosynthetic process (GO:0009435)2.82834534
80histone H3-K9 demethylation (GO:0033169)2.81514571
81regulation of regulatory T cell differentiation (GO:0045589)2.80538661
82cellular process involved in reproduction in multicellular organism (GO:0022412)2.80527845
83positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.79619626
84nephron tubule morphogenesis (GO:0072078)2.78970549
85nephron epithelium morphogenesis (GO:0072088)2.78970549
86germ cell development (GO:0007281)2.75437880
87regulation of granulocyte differentiation (GO:0030852)2.73522507
88cilium movement (GO:0003341)2.73225345
89urinary tract smooth muscle contraction (GO:0014848)2.71598159
90centriole assembly (GO:0098534)2.71294256
91peptidyl-threonine dephosphorylation (GO:0035970)2.67767856
92regulation of acrosome reaction (GO:0060046)2.67686750
93positive regulation of catenin import into nucleus (GO:0035413)2.67343897
94regulation of ARF GTPase activity (GO:0032312)2.63904348
95pore complex assembly (GO:0046931)2.63491951
964-hydroxyproline metabolic process (GO:0019471)2.60481215
97seminiferous tubule development (GO:0072520)2.57578291
98histone demethylation (GO:0016577)2.56096746
99organic cation transport (GO:0015695)2.55144697
100fusion of sperm to egg plasma membrane (GO:0007342)10.2819849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX_20019798_ChIP-Seq_JUKART_Human3.01362852
2FUS_26573619_Chip-Seq_HEK293_Human2.54146755
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38246554
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25607674
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.18770689
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12483986
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11823178
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.11718037
9CBP_20019798_ChIP-Seq_JUKART_Human2.11718037
10ER_23166858_ChIP-Seq_MCF-7_Human2.09525128
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01952754
12IRF8_22096565_ChIP-ChIP_GC-B_Human1.95260875
13ZNF274_21170338_ChIP-Seq_K562_Hela1.82752289
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73429229
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71659974
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69790568
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68906170
18VDR_22108803_ChIP-Seq_LS180_Human1.66327133
19EZH2_22144423_ChIP-Seq_EOC_Human1.63971119
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63386625
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.60529803
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60126743
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58606023
24GBX2_23144817_ChIP-Seq_PC3_Human1.56238768
25MYC_19829295_ChIP-Seq_ESCs_Human1.53641064
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52220867
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52220867
28HNFA_21074721_ChIP-Seq_CACO-2_Human1.52046094
29CJUN_26792858_Chip-Seq_BT549_Human1.51890535
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51367669
31TAF15_26573619_Chip-Seq_HEK293_Human1.50583442
32KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.49678024
33SMAD4_21741376_ChIP-Seq_EPCs_Human1.48566434
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47840350
35STAT3_23295773_ChIP-Seq_U87_Human1.45031126
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44176526
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41896977
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41843731
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.40840872
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.40484199
41KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39795066
42CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39384642
43TBL1_22424771_ChIP-Seq_293T_Human1.39245629
44ETV1_20927104_ChIP-Seq_GIST48_Human1.38644875
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38403892
46P300_19829295_ChIP-Seq_ESCs_Human1.36757499
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35382512
48PHF8_20622853_ChIP-Seq_HELA_Human1.32637786
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32034535
50NFYB_21822215_ChIP-Seq_K562_Human1.28871314
51RBPJ_21746931_ChIP-Seq_IB4_Human1.28754206
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27233969
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.27225914
54SMAD4_21741376_ChIP-Seq_HESCs_Human1.24770295
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24736681
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23227368
57RUNX2_22187159_ChIP-Seq_PCA_Human1.23134629
58RAC3_21632823_ChIP-Seq_H3396_Human1.23027780
59TCF4_23295773_ChIP-Seq_U87_Human1.22117613
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.21161490
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20639744
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20265354
63SMAD4_21799915_ChIP-Seq_A2780_Human1.19233356
64ERA_21632823_ChIP-Seq_H3396_Human1.18065054
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17999126
66DROSHA_22980978_ChIP-Seq_HELA_Human1.17795132
67SMRT_27268052_Chip-Seq_Bcells_Human1.17724396
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.15759571
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15145845
70AR_25329375_ChIP-Seq_VCAP_Human1.13561182
71TP63_23658742_ChIP-Seq_EP156T_Human1.13239034
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.12726196
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12679241
74AHR_22903824_ChIP-Seq_MCF-7_Human1.12496309
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.12262724
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12124917
77NFYA_21822215_ChIP-Seq_K562_Human1.11383499
78IGF1R_20145208_ChIP-Seq_DFB_Human1.10425674
79NANOG_20526341_ChIP-Seq_ESCs_Human1.09340631
80HOXB7_26014856_ChIP-Seq_BT474_Human1.08975993
81GATA1_19941826_ChIP-Seq_K562_Human1.08427280
82MYB_26560356_Chip-Seq_TH2_Human1.07883153
83TP53_18474530_ChIP-ChIP_U2OS_Human1.07152788
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05389718
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03429720
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03150192
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.03078223
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02361573
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02167817
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.01795601
91SOX2_19829295_ChIP-Seq_ESCs_Human1.01035059
92NANOG_19829295_ChIP-Seq_ESCs_Human1.01035059
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00256429
94KDM2B_26808549_Chip-Seq_REH_Human0.99741815
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98170865
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.95988216
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.95798098
98GATA2_19941826_ChIP-Seq_K562_Human0.94633080
99VDR_24787735_ChIP-Seq_THP-1_Human0.94544601
100KLF5_25053715_ChIP-Seq_YYC3_Human0.93844627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.36101292
2MP0001348_abnormal_lacrimal_gland4.02624239
3MP0005670_abnormal_white_adipose3.13749350
4MP0003698_abnormal_male_reproductive2.83050815
5MP0000569_abnormal_digit_pigmentation2.73001279
6MP0008961_abnormal_basal_metabolism2.43887108
7MP0001929_abnormal_gametogenesis2.42891888
8MP0004043_abnormal_pH_regulation2.20394627
9MP0005275_abnormal_skin_tensile1.98728808
10MP0003011_delayed_dark_adaptation1.96866090
11MP0000383_abnormal_hair_follicle1.82915061
12MP0002332_abnormal_exercise_endurance1.79743775
13MP0009384_cardiac_valve_regurgitation1.76742791
14MP0005310_abnormal_salivary_gland1.71365674
15MP0004510_myositis1.71002570
16MP0003878_abnormal_ear_physiology1.70015548
17MP0005377_hearing/vestibular/ear_phenot1.70015548
18MP0000003_abnormal_adipose_tissue1.68734964
19MP0001765_abnormal_ion_homeostasis1.68307696
20MP0001501_abnormal_sleep_pattern1.66772862
21MP0005379_endocrine/exocrine_gland_phen1.65740368
22MP0005375_adipose_tissue_phenotype1.62167265
23MP0003763_abnormal_thymus_physiology1.58917148
24MP0005503_abnormal_tendon_morphology1.57244813
25MP0004484_altered_response_of1.57041407
26MP0000427_abnormal_hair_cycle1.55905217
27MP0008995_early_reproductive_senescence1.55191015
28MP0008057_abnormal_DNA_replication1.50795036
29MP0002132_abnormal_respiratory_system1.49694442
30MP0000230_abnormal_systemic_arterial1.48757914
31MP0000678_abnormal_parathyroid_gland1.46710375
32MP0003718_maternal_effect1.43040006
33MP0002166_altered_tumor_susceptibility1.41727313
34MP0002971_abnormal_brown_adipose1.41603377
35MP0003195_calcinosis1.40794178
36MP0002161_abnormal_fertility/fecundity1.39200589
37MP0002733_abnormal_thermal_nociception1.38070178
38MP0003786_premature_aging1.36244013
39MP0003279_aneurysm1.34272103
40MP0001873_stomach_inflammation1.31248547
41MP0002127_abnormal_cardiovascular_syste1.30882571
42MP0001440_abnormal_grooming_behavior1.27887824
43MP0003724_increased_susceptibility_to1.25388663
44MP0005666_abnormal_adipose_tissue1.20095318
45MP0000015_abnormal_ear_pigmentation1.19132955
46MP0010678_abnormal_skin_adnexa1.16663581
47MP0008775_abnormal_heart_ventricle1.16405020
48MP0003221_abnormal_cardiomyocyte_apopto1.15815720
49MP0001970_abnormal_pain_threshold1.15459649
50MP0005164_abnormal_response_to1.13020218
51MP0001835_abnormal_antigen_presentation1.11428829
52MP0009115_abnormal_fat_cell1.09253933
53MP0005535_abnormal_body_temperature1.00374110
54MP0005645_abnormal_hypothalamus_physiol0.96255276
55MP0000249_abnormal_blood_vessel0.95807864
56MP0005166_decreased_susceptibility_to0.91491050
57MP0001968_abnormal_touch/_nociception0.89610835
58MP0002060_abnormal_skin_morphology0.89454313
59MP0005084_abnormal_gallbladder_morpholo0.89383712
60MP0002282_abnormal_trachea_morphology0.89274440
61MP0000371_diluted_coat_color0.88166074
62MP0003646_muscle_fatigue0.87712978
63MP0000767_abnormal_smooth_muscle0.85987532
64MP0001486_abnormal_startle_reflex0.85597646
65MP0006082_CNS_inflammation0.83929717
66MP0003172_abnormal_lysosome_physiology0.80581686
67MP0001879_abnormal_lymphatic_vessel0.80302500
68MP0002933_joint_inflammation0.79977538
69MP0005083_abnormal_biliary_tract0.79975353
70MP0008438_abnormal_cutaneous_collagen0.79870682
71MP0005409_darkened_coat_color0.79782210
72MP0005395_other_phenotype0.79190060
73MP0002210_abnormal_sex_determination0.78986146
74MP0004142_abnormal_muscle_tone0.76946327
75MP0005423_abnormal_somatic_nervous0.76603514
76MP0000013_abnormal_adipose_tissue0.76394729
77MP0000367_abnormal_coat/_hair0.76336985
78MP0005167_abnormal_blood-brain_barrier0.75557237
79MP0009780_abnormal_chondrocyte_physiolo0.73548422
80MP0002693_abnormal_pancreas_physiology0.72042104
81MP0009053_abnormal_anal_canal0.71635851
82MP0002108_abnormal_muscle_morphology0.71088540
83MP0001145_abnormal_male_reproductive0.71085429
84MP0005376_homeostasis/metabolism_phenot0.70173921
85MP0002229_neurodegeneration0.67844483
86MP0004085_abnormal_heartbeat0.67604304
87MP0010386_abnormal_urinary_bladder0.66130204
88MP0004808_abnormal_hematopoietic_stem0.65255523
89MP0005334_abnormal_fat_pad0.65196328
90MP0003633_abnormal_nervous_system0.64564635
91MP0004264_abnormal_extraembryonic_tissu0.63825025
92MP0002254_reproductive_system_inflammat0.63755315
93MP0001984_abnormal_olfaction0.63460023
94MP0009785_altered_susceptibility_to0.62675089
95MP0002006_tumorigenesis0.62081776
96MP0005266_abnormal_metabolism0.60737157
97MP0009764_decreased_sensitivity_to0.60536220
98MP0000653_abnormal_sex_gland0.60118764
99MP0005636_abnormal_mineral_homeostasis0.60045161
100MP0001800_abnormal_humoral_immune0.59564440

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.71429689
2Attenuation of retinal blood vessels (HP:0007843)4.67223462
3Unilateral renal agenesis (HP:0000122)4.24903011
4Abnormal rod and cone electroretinograms (HP:0008323)4.00051834
5Retinal atrophy (HP:0001105)3.98208073
6Bony spicule pigmentary retinopathy (HP:0007737)3.86926329
7Supernumerary ribs (HP:0005815)3.81466358
8Stomach cancer (HP:0012126)3.76034719
9Recurrent corneal erosions (HP:0000495)3.71891824
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.51213559
11Supernumerary bones of the axial skeleton (HP:0009144)3.50187452
12Aplasia/Hypoplasia of the tibia (HP:0005772)3.48620332
13Short tibia (HP:0005736)3.37334444
14Male infertility (HP:0003251)3.36247493
15Enlarged epiphyses (HP:0010580)3.32995081
16Absent/shortened dynein arms (HP:0200106)3.29629230
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.29629230
18Decreased central vision (HP:0007663)3.16494070
19Colon cancer (HP:0003003)3.15711218
20Hypophosphatemic rickets (HP:0004912)3.15538977
21Abnormality of macular pigmentation (HP:0008002)3.04427810
22Upper limb muscle weakness (HP:0003484)3.03077563
23Febrile seizures (HP:0002373)2.96626349
24Milia (HP:0001056)2.95520038
25Pendular nystagmus (HP:0012043)2.83786650
26Hypoplastic ischia (HP:0003175)2.79212756
27Neoplasm of the heart (HP:0100544)2.72554619
28Hyperkalemia (HP:0002153)2.71817075
29Heterotopia (HP:0002282)2.71178915
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68906078
31Chronic hepatic failure (HP:0100626)2.55489443
32Abnormality of the ischium (HP:0003174)2.52296821
33Sensory axonal neuropathy (HP:0003390)2.51764182
34Resting tremor (HP:0002322)2.49921459
35Cerebellar dysplasia (HP:0007033)2.47095266
36Abnormal spermatogenesis (HP:0008669)2.46558078
37Azoospermia (HP:0000027)2.45543701
38Neoplasm of the oral cavity (HP:0100649)2.42800883
39Bulbous nose (HP:0000414)2.39276586
40Abnormal ciliary motility (HP:0012262)2.39042043
41Horizontal nystagmus (HP:0000666)2.37014047
42Tubular atrophy (HP:0000092)2.32588099
43Polydipsia (HP:0001959)2.29726003
44Abnormal drinking behavior (HP:0030082)2.29726003
45Infertility (HP:0000789)2.25416150
46Macular degeneration (HP:0000608)2.22822069
47Osteomalacia (HP:0002749)2.21831851
48Bradycardia (HP:0001662)2.21071308
49Progressive sensorineural hearing impairment (HP:0000408)2.20232886
50Stage 5 chronic kidney disease (HP:0003774)2.19891325
51Ventricular tachycardia (HP:0004756)2.17023433
52Cheilitis (HP:0100825)2.15611295
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12884193
54Renal dysplasia (HP:0000110)2.12607911
55Muscle fiber splitting (HP:0003555)2.12043651
56Abnormal respiratory motile cilium physiology (HP:0012261)2.10052876
57Short phalanx of the thumb (HP:0009660)2.08894693
58Hypoplastic labia majora (HP:0000059)2.07738852
59Metaphyseal dysplasia (HP:0100255)2.07264254
60Abnormality of homocysteine metabolism (HP:0010919)2.06996347
61Homocystinuria (HP:0002156)2.06996347
62Alopecia of scalp (HP:0002293)2.04635260
63Zonular cataract (HP:0010920)2.02143926
64Portal hypertension (HP:0001409)2.02078655
65Generalized aminoaciduria (HP:0002909)2.00238282
66Potter facies (HP:0002009)1.96951750
67Facial shape deformation (HP:0011334)1.96951750
68Tubulointerstitial nephritis (HP:0001970)1.96783490
69Plagiocephaly (HP:0001357)1.96385868
70Flat capital femoral epiphysis (HP:0003370)1.95808059
71Abnormality of potassium homeostasis (HP:0011042)1.91222202
72Hypoplasia of the thymus (HP:0000778)1.88542640
73Fibular hypoplasia (HP:0003038)1.87349550
74Abnormality of the labia majora (HP:0012881)1.86665471
75Abnormal respiratory motile cilium morphology (HP:0005938)1.85216437
76Abnormal respiratory epithelium morphology (HP:0012253)1.85216437
77Failure to thrive in infancy (HP:0001531)1.84983991
78Nephronophthisis (HP:0000090)1.84393757
79Right ventricular cardiomyopathy (HP:0011663)1.82114697
80Abnormality of the hepatic vasculature (HP:0006707)1.79126537
81Abnormal biliary tract physiology (HP:0012439)1.78342257
82Bile duct proliferation (HP:0001408)1.78342257
83Elevated erythrocyte sedimentation rate (HP:0003565)1.78309743
84Episodic fever (HP:0001954)1.76345674
85Abnormal hair whorl (HP:0010721)1.75480953
86Medulloblastoma (HP:0002885)1.75468026
87Abnormal urine output (HP:0012590)1.74901558
88Absent thumb (HP:0009777)1.74834691
89Nasal polyposis (HP:0100582)1.70864290
90Epiphyseal dysplasia (HP:0002656)1.70729941
91Asymmetric septal hypertrophy (HP:0001670)1.69235164
92Abnormality of the parietal bone (HP:0002696)1.69226830
93Follicular hyperkeratosis (HP:0007502)1.68012506
94Corneal erosion (HP:0200020)1.67847372
95Polyuria (HP:0000103)1.66450490
96Pancreatic fibrosis (HP:0100732)1.65978110
97Overlapping toe (HP:0001845)1.65374881
98Abnormality of the femoral head (HP:0003368)1.64532513
99Abnormal albumin level (HP:0012116)1.63807074
100Hypoalbuminemia (HP:0003073)1.63807074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.30055544
2DDR22.68600068
3WNK12.55510600
4TESK12.42763426
5FRK2.29170203
6INSRR2.26703880
7MAP4K211.6584179
8WNK41.88830681
9BRD41.86616654
10TNIK1.81056981
11MAP3K21.62954002
12PIK3CG1.61486187
13KSR21.49355644
14TRIM281.43353293
15PRKG21.29530815
16PDK11.26602472
17MST1R1.19190976
18PDPK11.18648572
19PLK21.12187951
20ZAK1.11812332
21KSR11.08328106
22SIK31.03253881
23DAPK20.96510410
24PBK0.94540070
25CAMKK20.94165190
26STK380.92207272
27CDK40.89999580
28MAP3K120.88820739
29MAP3K90.88586420
30CDK120.86964971
31JAK10.83138417
32ITK0.80441653
33BLK0.77243139
34YES10.75425798
35MAP3K70.73418465
36MARK20.70157153
37MAP3K130.69836982
38PINK10.66151743
39PTK2B0.66059258
40MAP3K30.64085574
41CDK80.63452250
42DYRK30.63406787
43MAPK150.61297807
44HCK0.61145117
45RET0.60205290
46CDK30.58163065
47JAK30.58139124
48NEK60.57506716
49PRKAA20.56855371
50MYLK0.55091844
51DYRK1B0.53577277
52MAP3K40.53048671
53TXK0.53037227
54IKBKB0.52029517
55SGK2230.51926351
56SGK4940.51926351
57FGFR30.51337134
58BMX0.49315020
59BCR0.48776267
60BMPR1B0.47571998
61ERBB30.46688189
62MAP3K10.46288586
63PDGFRB0.44987396
64RPS6KA40.43778657
65MELK0.41553565
66PAK30.41526875
67NLK0.41079007
68TAOK30.40968429
69BTK0.40763343
70CAMK40.40631288
71EPHA30.40254444
72PRKG10.39927508
73LCK0.39877553
74JAK20.39374288
75ACVR1B0.38896824
76IKBKE0.38739797
77SYK0.38402759
78TYK20.37929269
79MET0.34330844
80SGK20.29617566
81RPS6KA50.28105768
82STK38L0.27683093
83FER0.26228209
84MAPK110.25612106
85MAPK10.24565243
86MAPK80.24323493
87PRKCQ0.23829861
88PIK3CA0.23817804
89PRKCE0.22999278
90CSNK1D0.22481050
91CAMK1G0.22438390
92RPS6KA20.21551413
93TEC0.21517738
94OXSR10.21212516
95CAMK10.20160239
96FGR0.18479640
97GSK3B0.18423742
98RAF10.18359446
99PRKD30.18243216
100MAP4K10.18065594

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14320976
2Graft-versus-host disease_Homo sapiens_hsa053323.07381704
3Autoimmune thyroid disease_Homo sapiens_hsa053202.76183375
4Type I diabetes mellitus_Homo sapiens_hsa049402.70618168
5Allograft rejection_Homo sapiens_hsa053302.65756071
6Fatty acid biosynthesis_Homo sapiens_hsa000612.43058770
7Olfactory transduction_Homo sapiens_hsa047402.41539824
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33767264
9Taste transduction_Homo sapiens_hsa047422.04103067
10Viral myocarditis_Homo sapiens_hsa054161.77799480
11Salivary secretion_Homo sapiens_hsa049701.64989079
12Circadian rhythm_Homo sapiens_hsa047101.57054580
13Dorso-ventral axis formation_Homo sapiens_hsa043201.56588512
14Acute myeloid leukemia_Homo sapiens_hsa052211.56024044
15Antigen processing and presentation_Homo sapiens_hsa046121.44953212
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.36196298
17Renin secretion_Homo sapiens_hsa049241.35120912
18Butanoate metabolism_Homo sapiens_hsa006501.31117672
19Long-term depression_Homo sapiens_hsa047301.26226649
20Endocytosis_Homo sapiens_hsa041441.24633590
21Type II diabetes mellitus_Homo sapiens_hsa049301.21982236
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.17199192
23Insulin secretion_Homo sapiens_hsa049111.14463472
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11843471
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.09290508
26Platelet activation_Homo sapiens_hsa046111.06135765
27Herpes simplex infection_Homo sapiens_hsa051681.03719129
28Measles_Homo sapiens_hsa051621.03039518
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01672324
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00120998
31Influenza A_Homo sapiens_hsa051640.99399994
32mRNA surveillance pathway_Homo sapiens_hsa030150.98652756
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94846122
34FoxO signaling pathway_Homo sapiens_hsa040680.92941489
35T cell receptor signaling pathway_Homo sapiens_hsa046600.91965082
36Vascular smooth muscle contraction_Homo sapiens_hsa042700.91584439
37Adherens junction_Homo sapiens_hsa045200.88507717
38Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88087615
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87134415
40ABC transporters_Homo sapiens_hsa020100.86972928
41Prolactin signaling pathway_Homo sapiens_hsa049170.85359432
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.80904325
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77297328
44Gap junction_Homo sapiens_hsa045400.75929155
45Nitrogen metabolism_Homo sapiens_hsa009100.75572315
46Circadian entrainment_Homo sapiens_hsa047130.74564603
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74393670
48Caffeine metabolism_Homo sapiens_hsa002320.74342162
49Insulin resistance_Homo sapiens_hsa049310.71332788
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69415366
51Toxoplasmosis_Homo sapiens_hsa051450.68043370
52Estrogen signaling pathway_Homo sapiens_hsa049150.67287943
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66340920
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64775018
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.63630868
56cAMP signaling pathway_Homo sapiens_hsa040240.63525325
57Cocaine addiction_Homo sapiens_hsa050300.63198178
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63017612
59RNA transport_Homo sapiens_hsa030130.62765510
60MAPK signaling pathway_Homo sapiens_hsa040100.62052879
61Oocyte meiosis_Homo sapiens_hsa041140.60318615
62Choline metabolism in cancer_Homo sapiens_hsa052310.59268759
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56033508
64Amphetamine addiction_Homo sapiens_hsa050310.54851861
65Cholinergic synapse_Homo sapiens_hsa047250.54664666
66Morphine addiction_Homo sapiens_hsa050320.54393085
67B cell receptor signaling pathway_Homo sapiens_hsa046620.54336233
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54136097
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53740909
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53053627
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52380227
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52228015
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.52147096
74ECM-receptor interaction_Homo sapiens_hsa045120.51862210
75Retinol metabolism_Homo sapiens_hsa008300.51600114
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50631870
77Glutamatergic synapse_Homo sapiens_hsa047240.50333648
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48748620
79Primary immunodeficiency_Homo sapiens_hsa053400.48575458
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47396186
81Glycerolipid metabolism_Homo sapiens_hsa005610.46154465
82Selenocompound metabolism_Homo sapiens_hsa004500.46146571
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45533488
84Phototransduction_Homo sapiens_hsa047440.44808225
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.44149443
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43605475
87Focal adhesion_Homo sapiens_hsa045100.42856680
88Calcium signaling pathway_Homo sapiens_hsa040200.42720186
89Chemokine signaling pathway_Homo sapiens_hsa040620.42166157
90RNA degradation_Homo sapiens_hsa030180.41501116
91Hematopoietic cell lineage_Homo sapiens_hsa046400.41316313
92Oxytocin signaling pathway_Homo sapiens_hsa049210.41041788
93Serotonergic synapse_Homo sapiens_hsa047260.40456447
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40214152
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39943329
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39535225
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39068463
98Arginine biosynthesis_Homo sapiens_hsa002200.39060310
99Long-term potentiation_Homo sapiens_hsa047200.38046165
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.37046785

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