CTAGE7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)6.61940615
2nuclear pore complex assembly (GO:0051292)5.54253900
3leukotriene metabolic process (GO:0006691)4.96979149
4regulation of histone H3-K27 methylation (GO:0061085)4.61757339
5nuclear pore organization (GO:0006999)4.56866222
6histone H3-K9 demethylation (GO:0033169)4.50463408
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45694457
8histone H3-K36 demethylation (GO:0070544)4.36200390
9peptide catabolic process (GO:0043171)4.33861281
10regulation of B cell receptor signaling pathway (GO:0050855)4.26776131
11detection of molecule of bacterial origin (GO:0032490)4.13864834
12B cell receptor signaling pathway (GO:0050853)4.11876983
13positive regulation of gamma-delta T cell activation (GO:0046645)4.09700283
14pore complex assembly (GO:0046931)3.93443492
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93317368
16negative regulation of cell killing (GO:0031342)3.93317368
17DNA synthesis involved in DNA repair (GO:0000731)3.91928654
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.91274296
19negative regulation of cAMP-mediated signaling (GO:0043951)3.65640457
20positive regulation of granulocyte differentiation (GO:0030854)3.60961244
21cysteine metabolic process (GO:0006534)3.59154321
22mitotic sister chromatid cohesion (GO:0007064)3.56842788
23regulation of interferon-beta biosynthetic process (GO:0045357)3.56272665
24T cell migration (GO:0072678)3.51382671
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.46454726
26modulation by symbiont of host immune response (GO:0052553)3.46454726
27positive regulation by symbiont of host defense response (GO:0052509)3.46454726
28modulation by symbiont of host defense response (GO:0052031)3.46454726
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46454726
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46454726
31icosanoid biosynthetic process (GO:0046456)3.42183669
32fatty acid derivative biosynthetic process (GO:1901570)3.42183669
33B cell proliferation (GO:0042100)3.36596318
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33799472
35regulation of DNA damage checkpoint (GO:2000001)3.33360474
36negative T cell selection (GO:0043383)3.28939404
37histone lysine demethylation (GO:0070076)3.26109212
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26073389
39DNA packaging (GO:0006323)3.23122567
40V(D)J recombination (GO:0033151)3.21261498
41negative thymic T cell selection (GO:0045060)3.20259307
42chromosome condensation (GO:0030261)3.15062969
43protein targeting to Golgi (GO:0000042)3.04639825
44thymic T cell selection (GO:0045061)3.04501359
45T cell selection (GO:0045058)3.04435560
46negative regulation of T cell mediated immunity (GO:0002710)3.03327147
47antigen processing and presentation of endogenous antigen (GO:0019883)3.03136913
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02893239
49histone demethylation (GO:0016577)3.01826437
50regulation of RIG-I signaling pathway (GO:0039535)2.97566896
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97446574
52positive thymic T cell selection (GO:0045059)2.97133802
53response to interleukin-15 (GO:0070672)2.94023113
54regulation of B cell differentiation (GO:0045577)2.93390025
55natural killer cell differentiation (GO:0001779)2.93376094
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91640273
57negative regulation of erythrocyte differentiation (GO:0045647)2.89037423
58positive regulation of B cell differentiation (GO:0045579)2.88673760
59unsaturated fatty acid biosynthetic process (GO:0006636)2.86214135
60establishment of protein localization to Golgi (GO:0072600)2.84776893
61detection of external biotic stimulus (GO:0098581)2.83714894
62retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83659723
63positive T cell selection (GO:0043368)2.82703519
64cellular extravasation (GO:0045123)2.82634612
65negative regulation of necroptotic process (GO:0060546)2.79460270
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79138193
67regulation of gamma-delta T cell differentiation (GO:0045586)2.75140381
68dosage compensation (GO:0007549)2.73958683
69regulation of necroptotic process (GO:0060544)2.73166173
70macrophage activation involved in immune response (GO:0002281)2.72919665
71definitive hemopoiesis (GO:0060216)2.72121117
72regulation of gamma-delta T cell activation (GO:0046643)2.71479293
73mitotic chromosome condensation (GO:0007076)2.68204577
74negative regulation of lymphocyte mediated immunity (GO:0002707)2.66400968
75positive regulation of T cell cytokine production (GO:0002726)2.64684247
76hepatocyte apoptotic process (GO:0097284)2.61760854
77histone H4-K16 acetylation (GO:0043984)2.57514613
78regulation of RNA export from nucleus (GO:0046831)2.57451644
79regulation of granulocyte differentiation (GO:0030852)2.56735994
80negative regulation of stress fiber assembly (GO:0051497)2.56236411
81protein demethylation (GO:0006482)2.56087786
82protein dealkylation (GO:0008214)2.56087786
83positive regulation of interferon-alpha production (GO:0032727)2.54739639
84cellular response to interleukin-15 (GO:0071350)2.54710538
85sister chromatid cohesion (GO:0007062)2.50201307
86embryonic process involved in female pregnancy (GO:0060136)2.49179807
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.48237244
88viral mRNA export from host cell nucleus (GO:0046784)2.45152757
89regulation of establishment of cell polarity (GO:2000114)2.43054399
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.42887958
91DNA conformation change (GO:0071103)2.41694864
92synaptonemal complex assembly (GO:0007130)2.41022306
93histone-serine phosphorylation (GO:0035404)2.40938371
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40021239
95negative regulation of mRNA metabolic process (GO:1903312)2.39040643
96chromosome organization involved in meiosis (GO:0070192)2.37461221
97megakaryocyte development (GO:0035855)2.37456301
98monoubiquitinated protein deubiquitination (GO:0035520)2.37231832
99response to peptidoglycan (GO:0032494)2.34620332
100DNA unwinding involved in DNA replication (GO:0006268)2.34500528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51768313
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40606511
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26221269
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93841593
5MYC_22102868_ChIP-Seq_BL_Human3.42502511
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.04681788
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.00551324
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88438521
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86809912
10MYB_26560356_Chip-Seq_TH2_Human2.84909626
11SCL_19346495_ChIP-Seq_HPC-7_Human2.55070718
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54849069
13MYB_26560356_Chip-Seq_TH1_Human2.53226617
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44971734
15MAF_26560356_Chip-Seq_TH1_Human2.44056761
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41926806
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41295902
18VDR_21846776_ChIP-Seq_THP-1_Human2.36619442
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33423419
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32260837
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10980919
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10391900
23RUNX_20019798_ChIP-Seq_JUKART_Human2.09923004
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09699606
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09123777
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.08604507
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08006938
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04095078
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01919468
30TCF7_22412390_ChIP-Seq_EML_Mouse1.95417679
31MAF_26560356_Chip-Seq_TH2_Human1.92046335
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91931616
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.87583966
34SPI1_23547873_ChIP-Seq_NB4_Human1.77653588
35CIITA_25753668_ChIP-Seq_RAJI_Human1.76350282
36UTX_26944678_Chip-Seq_JUKART_Human1.76228719
37VDR_24763502_ChIP-Seq_THP-1_Human1.74760978
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.74049867
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71543862
40GATA3_27048872_Chip-Seq_THYMUS_Human1.67854781
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67703455
42GATA1_22025678_ChIP-Seq_K562_Human1.61444667
43SPI1_23127762_ChIP-Seq_K562_Human1.58448787
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.56362058
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47748289
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46567790
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.45899317
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44357808
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40330648
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37447844
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35866362
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30575905
53NCOR1_26117541_ChIP-Seq_K562_Human1.29781708
54PU_27001747_Chip-Seq_BMDM_Mouse1.29671508
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26766752
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26179421
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.24369539
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23490572
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22891397
60KDM2B_26808549_Chip-Seq_DND41_Human1.22477477
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17365874
62GATA3_26560356_Chip-Seq_TH1_Human1.16992242
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09381757
64TFEB_21752829_ChIP-Seq_HELA_Human1.08318716
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06950236
66GATA3_26560356_Chip-Seq_TH2_Human1.05551585
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03072049
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02795168
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00762306
70GATA1_19941827_ChIP-Seq_MEL_Mouse0.99598723
71GATA1_19941826_ChIP-Seq_K562_Human0.99516742
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98851851
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97262908
74ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96745047
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96065318
76ESR1_20079471_ChIP-ChIP_T-47D_Human0.93825956
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92647926
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92063715
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91882995
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.91774117
81KDM5A_27292631_Chip-Seq_BREAST_Human0.89958447
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87412301
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87345163
84CHD1_26751641_Chip-Seq_LNCaP_Human0.86714649
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85803410
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85802831
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82676851
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82399067
89MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82185865
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.80768753
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80173400
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79684698
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79613769
94GATA2_19941826_ChIP-Seq_K562_Human0.79462090
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77679695
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.76811576
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.76409550
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.76033543
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.74921570
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74345068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.63124408
2MP0008057_abnormal_DNA_replication3.96125134
3MP0003183_abnormal_peptide_metabolism3.91847270
4MP0003763_abnormal_thymus_physiology3.19341279
5MP0002009_preneoplasia3.15246559
6MP0001835_abnormal_antigen_presentation2.82486044
7MP0002163_abnormal_gland_morphology2.69126856
8MP0002166_altered_tumor_susceptibility2.68516571
9MP0001800_abnormal_humoral_immune2.39398872
10MP0000685_abnormal_immune_system2.24046994
11MP0005379_endocrine/exocrine_gland_phen2.20083275
12MP0003300_gastrointestinal_ulcer2.20061955
13MP0003303_peritoneal_inflammation2.16341270
14MP0010094_abnormal_chromosome_stability2.15954546
15MP0008260_abnormal_autophagy2.05776563
16MP0002396_abnormal_hematopoietic_system2.02971077
17MP0002398_abnormal_bone_marrow1.97149675
18MP0005387_immune_system_phenotype1.95828998
19MP0001790_abnormal_immune_system1.95828998
20MP0003436_decreased_susceptibility_to1.95034058
21MP0005671_abnormal_response_to1.91744095
22MP0003111_abnormal_nucleus_morphology1.91352988
23MP0000703_abnormal_thymus_morphology1.80967017
24MP0002420_abnormal_adaptive_immunity1.79869034
25MP0002006_tumorigenesis1.79475960
26MP0005000_abnormal_immune_tolerance1.78724149
27MP0002452_abnormal_antigen_presenting1.77880154
28MP0001819_abnormal_immune_cell1.77405174
29MP0002723_abnormal_immune_serum1.74810839
30MP0009333_abnormal_splenocyte_physiolog1.68955445
31MP0000716_abnormal_immune_system1.67916569
32MP0003077_abnormal_cell_cycle1.60802935
33MP0002722_abnormal_immune_system1.57927777
34MP0000689_abnormal_spleen_morphology1.56566795
35MP0002877_abnormal_melanocyte_morpholog1.56408599
36MP0005076_abnormal_cell_differentiation1.55126153
37MP0003693_abnormal_embryo_hatching1.54855404
38MP0004381_abnormal_hair_follicle1.54071248
39MP0002429_abnormal_blood_cell1.50447075
40MP0004957_abnormal_blastocyst_morpholog1.49402358
41MP0005310_abnormal_salivary_gland1.48309654
42MP0003705_abnormal_hypodermis_morpholog1.46494743
43MP0005410_abnormal_fertilization1.41471272
44MP0005666_abnormal_adipose_tissue1.36869096
45MP0001873_stomach_inflammation1.36590402
46MP0002419_abnormal_innate_immunity1.33963863
47MP0002405_respiratory_system_inflammati1.33805570
48MP0005025_abnormal_response_to1.30677009
49MP0001348_abnormal_lacrimal_gland1.29377238
50MP0004185_abnormal_adipocyte_glucose1.27024143
51MP0000371_diluted_coat_color1.24435644
52MP0004808_abnormal_hematopoietic_stem1.21599201
53MP0005464_abnormal_platelet_physiology1.17815971
54MP0008058_abnormal_DNA_repair1.13996931
55MP0002089_abnormal_postnatal_growth/wei1.12383890
56MP0003191_abnormal_cellular_cholesterol1.11181274
57MP0000350_abnormal_cell_proliferation1.08195115
58MP0009785_altered_susceptibility_to1.07536506
59MP0010352_gastrointestinal_tract_polyps1.06230661
60MP0003656_abnormal_erythrocyte_physiolo1.04530708
61MP0010155_abnormal_intestine_physiology1.02779918
62MP0004947_skin_inflammation1.02749000
63MP0008007_abnormal_cellular_replicative0.98229206
64MP0003172_abnormal_lysosome_physiology0.97878458
65MP0003828_pulmonary_edema0.96324807
66MP0003866_abnormal_defecation0.94911308
67MP0001730_embryonic_growth_arrest0.94517836
68MP0001845_abnormal_inflammatory_respons0.93308265
69MP0002019_abnormal_tumor_incidence0.92170589
70MP0003724_increased_susceptibility_to0.90609488
71MP0001929_abnormal_gametogenesis0.88516774
72MP0000858_altered_metastatic_potential0.86146510
73MP0005375_adipose_tissue_phenotype0.85621909
74MP0005621_abnormal_cell_physiology0.85011382
75MP0002132_abnormal_respiratory_system0.84991701
76MP0005220_abnormal_exocrine_pancreas0.83641220
77MP0003221_abnormal_cardiomyocyte_apopto0.83136463
78MP0010307_abnormal_tumor_latency0.82800547
79MP0002971_abnormal_brown_adipose0.78025657
80MP0002086_abnormal_extraembryonic_tissu0.75885088
81MP0002970_abnormal_white_adipose0.75233570
82MP0009115_abnormal_fat_cell0.74450404
83MP0009278_abnormal_bone_marrow0.73708732
84MP0000490_abnormal_crypts_of0.73532713
85MP0000313_abnormal_cell_death0.72066715
86MP0001853_heart_inflammation0.71063579
87MP0003091_abnormal_cell_migration0.71016926
88MP0003984_embryonic_growth_retardation0.70912322
89MP0005377_hearing/vestibular/ear_phenot0.70227832
90MP0003878_abnormal_ear_physiology0.70227832
91MP0005397_hematopoietic_system_phenotyp0.69490875
92MP0001545_abnormal_hematopoietic_system0.69490875
93MP0003448_altered_tumor_morphology0.69040887
94MP0004264_abnormal_extraembryonic_tissu0.68447357
95MP0003453_abnormal_keratinocyte_physiol0.68374789
96MP0004019_abnormal_vitamin_homeostasis0.68134747
97MP0005380_embryogenesis_phenotype0.67999181
98MP0001672_abnormal_embryogenesis/_devel0.67999181
99MP0003698_abnormal_male_reproductive0.67499012
100MP0004510_myositis0.66843466

Predicted human phenotypes

RankGene SetZ-score
1Vertebral arch anomaly (HP:0008438)4.36424281
2Abnormality of the lumbar spine (HP:0100712)4.05078389
3Flat acetabular roof (HP:0003180)3.92368707
4Colitis (HP:0002583)3.85566499
5Slow saccadic eye movements (HP:0000514)3.77280597
6Thoracic kyphosis (HP:0002942)3.59201034
7Recurrent bronchitis (HP:0002837)3.55247496
8Recurrent viral infections (HP:0004429)3.39405532
9Diastasis recti (HP:0001540)3.36563958
10T lymphocytopenia (HP:0005403)3.36334298
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.32508707
12Abnormality of the thoracic spine (HP:0100711)3.32191657
13Broad alveolar ridges (HP:0000187)3.24499324
14Thickened calvaria (HP:0002684)3.23490905
15J-shaped sella turcica (HP:0002680)3.11794891
16Thoracolumbar scoliosis (HP:0002944)3.11086606
17Gastrointestinal stroma tumor (HP:0100723)3.08621271
18Inflammation of the large intestine (HP:0002037)3.05093444
19Gastrointestinal inflammation (HP:0004386)3.02681788
20Spontaneous hematomas (HP:0007420)3.00362796
21Panhypogammaglobulinemia (HP:0003139)2.95120121
22Recurrent bacterial skin infections (HP:0005406)2.93472411
23Carpal bone hypoplasia (HP:0001498)2.90890411
24Abnormality of T cell number (HP:0011839)2.89384196
25Hypoplasia of the thymus (HP:0000778)2.83972747
26Broad ribs (HP:0000885)2.75986855
27Agammaglobulinemia (HP:0004432)2.74425402
28Lymphopenia (HP:0001888)2.73489759
29Recurrent abscess formation (HP:0002722)2.69629209
30Meningitis (HP:0001287)2.61152930
31Encephalitis (HP:0002383)2.60159625
32Asymmetry of the thorax (HP:0001555)2.60124649
33Abnormality of T cells (HP:0002843)2.60086172
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.58016438
35Viral hepatitis (HP:0006562)2.56625134
36Abnormality of the fingertips (HP:0001211)2.56156989
37Recurrent fungal infections (HP:0002841)2.52581056
38Progressive external ophthalmoplegia (HP:0000590)2.52371201
39Recurrent cutaneous fungal infections (HP:0011370)2.52182134
40Chronic mucocutaneous candidiasis (HP:0002728)2.52182134
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.52017595
42Vasculitis (HP:0002633)2.51126255
43Termporal pattern (HP:0011008)2.35632608
44Insidious onset (HP:0003587)2.35632608
45Eczematoid dermatitis (HP:0000976)2.31878048
46Cellulitis (HP:0100658)2.30672928
47Gingivitis (HP:0000230)2.27924483
48Recurrent pneumonia (HP:0006532)2.20151258
49Lymphoma (HP:0002665)2.19930530
50Deformed sella turcica (HP:0002681)2.18187288
51Orthostatic hypotension (HP:0001278)2.17892040
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14538162
53Sandal gap (HP:0001852)2.12997732
54Recurrent skin infections (HP:0001581)2.11359195
55Aplasia/Hypoplasia of the thymus (HP:0010515)2.09791300
56Hepatitis (HP:0012115)2.07840758
57Metaphyseal cupping (HP:0003021)2.07609125
5811 pairs of ribs (HP:0000878)2.06799946
59Syringomyelia (HP:0003396)2.06025792
60Spinal cord lesions (HP:0100561)2.06025792
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05922128
62Recurrent otitis media (HP:0000403)2.05561606
63Recurrent lower respiratory tract infections (HP:0002783)2.05038846
64Abnormality of DNA repair (HP:0003254)2.03462928
65Mediastinal lymphadenopathy (HP:0100721)2.03236902
66Aortic regurgitation (HP:0001659)2.02170190
67Abnormality of glycolipid metabolism (HP:0010969)2.01815005
68Abnormality of liposaccharide metabolism (HP:0010968)2.01815005
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.01815005
70Combined immunodeficiency (HP:0005387)2.00362966
71Poikiloderma (HP:0001029)1.99468199
72Nonprogressive disorder (HP:0003680)1.94392810
73Chromsome breakage (HP:0040012)1.93506252
74Severe combined immunodeficiency (HP:0004430)1.92797000
75Recurrent sinusitis (HP:0011108)1.92544243
76IgM deficiency (HP:0002850)1.92485655
77Obstructive lung disease (HP:0006536)1.91025625
78Chronic obstructive pulmonary disease (HP:0006510)1.91025625
79Abnormal foot bone ossification (HP:0010675)1.90368088
80Dysmetric saccades (HP:0000641)1.89775244
81IgA deficiency (HP:0002720)1.88959987
82Gastrointestinal infarctions (HP:0005244)1.88804070
83Subaortic stenosis (HP:0001682)1.87547695
84Abnormality of the left ventricular outflow tract (HP:0011103)1.87547695
85Abnormality of chromosome segregation (HP:0002916)1.86331039
86Acute hepatic failure (HP:0006554)1.86160053
87Bronchitis (HP:0012387)1.83744058
88Nephroblastoma (Wilms tumor) (HP:0002667)1.83688760
89Epistaxis (HP:0000421)1.83414717
90Autoimmune hemolytic anemia (HP:0001890)1.83077494
91Abnormality of T cell physiology (HP:0011840)1.83061909
92Arterial thrombosis (HP:0004420)1.81743044
93Prolonged bleeding time (HP:0003010)1.80496492
94Abnormality of the alveolar ridges (HP:0006477)1.79083563
95Pustule (HP:0200039)1.78606177
96Protuberant abdomen (HP:0001538)1.77007678
97Gingival bleeding (HP:0000225)1.75933085
98Restrictive lung disease (HP:0002091)1.74842527
99Keratoconjunctivitis sicca (HP:0001097)1.70990232
100Menstrual irregularities (HP:0000858)1.70187970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.54951338
2CDK123.73388727
3PRPF4B3.52121781
4MAP4K12.59309849
5BRD42.34660304
6MAP3K102.28079036
7SMG12.22454631
8MAP2K32.19253749
9ICK2.02529598
10EEF2K1.96418780
11TRIB31.94653171
12CAMKK21.87313204
13WNK11.84342821
14IRAK41.74996742
15BLK1.72793884
16CDK61.67586050
17MAP3K21.64546082
18NLK1.62231766
19YES11.61954458
20BMPR21.57224001
21NEK91.57044833
22TYK21.54179903
23MAP3K131.49994526
24PLK41.49188304
25MAP3K141.45276967
26BTK1.43716413
27FES1.40134536
28FGFR41.30837548
29FGFR31.30486717
30INSRR1.25567745
31SYK1.21188251
32RPS6KB21.17108166
33CDK41.16399050
34MAPK111.16001833
35MELK1.13333247
36GRK61.06911234
37CSK1.06245401
38PIM11.04773875
39WNK41.03740337
40MAP3K71.02083026
41SCYL21.02078225
42KSR21.01607980
43JAK11.00489322
44TAF10.96094038
45PKN20.94567253
46PDK10.93896000
47SIK10.93373326
48ITK0.91691990
49SIK20.90938678
50CAMKK10.90639931
51CAMK40.89899474
52TEC0.86316825
53LYN0.84072108
54HIPK20.83696219
55CSF1R0.82858033
56JAK20.79228739
57FGR0.79175070
58HCK0.78838120
59MAP3K30.78393808
60DYRK1B0.76816707
61PIK3CG0.76035066
62RPS6KA40.73981037
63PDPK10.73516668
64TAOK20.70913099
65MARK30.70070328
66IKBKE0.69996899
67RPS6KL10.66350965
68RPS6KC10.66350965
69PASK0.66305017
70ERN10.65119088
71JAK30.65023543
72RPS6KA60.63435860
73LCK0.62667795
74MAP3K80.61667399
75MAP3K10.60163841
76CLK10.59826613
77RPS6KB10.59273362
78CHEK10.59131140
79ATR0.58888291
80RET0.58449605
81MATK0.57493062
82MTOR0.56707860
83SRPK10.56633536
84SGK20.56325005
85IRAK20.55691539
86SIK30.55336434
87SGK30.55331104
88TYRO30.54764721
89BRSK20.50372730
90TXK0.49311501
91PTK2B0.49265932
92TRPM70.47845555
93IRAK30.44752414
94CDK70.41805077
95CDC70.41590570
96ZAP700.41506873
97IKBKB0.41400947
98CDK190.40592200
99MST1R0.38516669
100STK40.37594419

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.43494932
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.28026058
3T cell receptor signaling pathway_Homo sapiens_hsa046602.41253683
4Primary immunodeficiency_Homo sapiens_hsa053402.18171874
5Non-small cell lung cancer_Homo sapiens_hsa052232.14360459
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12854422
7VEGF signaling pathway_Homo sapiens_hsa043701.94906630
8Osteoclast differentiation_Homo sapiens_hsa043801.85903361
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80780063
10Acute myeloid leukemia_Homo sapiens_hsa052211.80223270
11Chronic myeloid leukemia_Homo sapiens_hsa052201.75630046
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.75327148
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57092767
14Measles_Homo sapiens_hsa051621.56723149
15Leishmaniasis_Homo sapiens_hsa051401.52572715
16Graft-versus-host disease_Homo sapiens_hsa053321.46274533
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42647337
18Autoimmune thyroid disease_Homo sapiens_hsa053201.42297884
19Allograft rejection_Homo sapiens_hsa053301.42270589
20Viral carcinogenesis_Homo sapiens_hsa052031.40674352
21Hepatitis B_Homo sapiens_hsa051611.38723803
22Long-term potentiation_Homo sapiens_hsa047201.37180422
23Antigen processing and presentation_Homo sapiens_hsa046121.36466625
24Thyroid cancer_Homo sapiens_hsa052161.31875089
25mRNA surveillance pathway_Homo sapiens_hsa030151.30909542
26Influenza A_Homo sapiens_hsa051641.27744737
27Toxoplasmosis_Homo sapiens_hsa051451.27322162
28Pancreatic cancer_Homo sapiens_hsa052121.27081550
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24672293
30Herpes simplex infection_Homo sapiens_hsa051681.23124330
31Prostate cancer_Homo sapiens_hsa052151.22525059
32HTLV-I infection_Homo sapiens_hsa051661.22518970
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17102748
34Endometrial cancer_Homo sapiens_hsa052131.17076435
35Tuberculosis_Homo sapiens_hsa051521.14351217
36Inositol phosphate metabolism_Homo sapiens_hsa005621.13476699
37Fatty acid biosynthesis_Homo sapiens_hsa000611.12160053
38Renal cell carcinoma_Homo sapiens_hsa052111.11899022
39Small cell lung cancer_Homo sapiens_hsa052221.11183650
40Hematopoietic cell lineage_Homo sapiens_hsa046401.08306550
41mTOR signaling pathway_Homo sapiens_hsa041501.08147859
42Cell cycle_Homo sapiens_hsa041101.02858709
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02733650
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.00892374
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99365319
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99127033
47Chemokine signaling pathway_Homo sapiens_hsa040620.98824705
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98764531
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95353968
50TNF signaling pathway_Homo sapiens_hsa046680.94663449
51Spliceosome_Homo sapiens_hsa030400.94510484
52RNA transport_Homo sapiens_hsa030130.93801274
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93366362
54Apoptosis_Homo sapiens_hsa042100.92931579
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92073964
56Glioma_Homo sapiens_hsa052140.91362288
57Epstein-Barr virus infection_Homo sapiens_hsa051690.90698072
58Platelet activation_Homo sapiens_hsa046110.90110900
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.89797095
60Viral myocarditis_Homo sapiens_hsa054160.88424113
61Type I diabetes mellitus_Homo sapiens_hsa049400.87910617
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87645453
63Prolactin signaling pathway_Homo sapiens_hsa049170.86683146
64Staphylococcus aureus infection_Homo sapiens_hsa051500.86468142
65MicroRNAs in cancer_Homo sapiens_hsa052060.83533690
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81569900
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.77559941
68Colorectal cancer_Homo sapiens_hsa052100.76063721
69DNA replication_Homo sapiens_hsa030300.76063552
70Non-homologous end-joining_Homo sapiens_hsa034500.75922609
71Systemic lupus erythematosus_Homo sapiens_hsa053220.73974471
72Oocyte meiosis_Homo sapiens_hsa041140.72409023
73FoxO signaling pathway_Homo sapiens_hsa040680.72276344
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.70912699
75Notch signaling pathway_Homo sapiens_hsa043300.68922093
76HIF-1 signaling pathway_Homo sapiens_hsa040660.68115235
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67571857
78Pentose phosphate pathway_Homo sapiens_hsa000300.66764445
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.66692473
80Choline metabolism in cancer_Homo sapiens_hsa052310.65970322
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65911137
82ErbB signaling pathway_Homo sapiens_hsa040120.65840260
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64346137
84Bladder cancer_Homo sapiens_hsa052190.63643850
85Insulin resistance_Homo sapiens_hsa049310.62880496
86Hepatitis C_Homo sapiens_hsa051600.61623808
87One carbon pool by folate_Homo sapiens_hsa006700.61540940
88Malaria_Homo sapiens_hsa051440.59085043
89Type II diabetes mellitus_Homo sapiens_hsa049300.59067984
90Renin secretion_Homo sapiens_hsa049240.58555025
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58525853
92MAPK signaling pathway_Homo sapiens_hsa040100.56465630
93GnRH signaling pathway_Homo sapiens_hsa049120.54716779
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.51196032
95Insulin signaling pathway_Homo sapiens_hsa049100.50594483
96Glucagon signaling pathway_Homo sapiens_hsa049220.50495988
97Dorso-ventral axis formation_Homo sapiens_hsa043200.49570016
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49516945
99Estrogen signaling pathway_Homo sapiens_hsa049150.47789130
100Mismatch repair_Homo sapiens_hsa034300.47495401

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