ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	9.24588281
2	DNA synthesis involved in DNA repair (GO:0000731)	8.55508366
3	chromosome organization involved in meiosis (GO:0070192)	8.45468930
4	meiosis I (GO:0007127)	7.81443214
5	piRNA metabolic process (GO:0034587)	7.72902605
6	male meiosis (GO:0007140)	7.45670972
7	DNA methylation involved in gamete generation (GO:0043046)	6.79475987
8	synaptonemal complex assembly (GO:0007130)	6.58311561
9	synaptonemal complex organization (GO:0070193)	6.00212070
10	meiotic nuclear division (GO:0007126)	5.75699248
11	reciprocal DNA recombination (GO:0035825)	5.58993114
12	reciprocal meiotic recombination (GO:0007131)	5.58993114
13	resolution of meiotic recombination intermediates (GO:0000712)	4.93821744
14	meiotic cell cycle process (GO:1903046)	4.89778018
15	maturation of SSU-rRNA (GO:0030490)	4.63142463
16	proteasome assembly (GO:0043248)	4.20895210
17	ribosome assembly (GO:0042255)	4.15921279
18	ATP synthesis coupled proton transport (GO:0015986)	3.77783436
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.77783436
20	regulation of cilium movement (GO:0003352)	3.76330676
21	regulation of meiosis I (GO:0060631)	3.68242555
22	DNA double-strand break processing (GO:0000729)	3.60706342
23	cell wall macromolecule catabolic process (GO:0016998)	3.57662789
24	sister chromatid cohesion (GO:0007062)	3.52321203
25	short-chain fatty acid metabolic process (GO:0046459)	3.51093309
26	protein localization to chromosome (GO:0034502)	3.45459652
27	nonmotile primary cilium assembly (GO:0035058)	3.39331418
28	sperm motility (GO:0030317)	3.33226875
29	gene silencing by RNA (GO:0031047)	3.31477338
30	chaperone-mediated protein transport (GO:0072321)	3.30876601
31	spermatid development (GO:0007286)	3.27958762
32	histone exchange (GO:0043486)	3.22130749
33	DNA catabolic process, exonucleolytic (GO:0000738)	3.21748752
34	ribosomal small subunit biogenesis (GO:0042274)	3.17253530
35	female gamete generation (GO:0007292)	3.16770337
36	cell wall macromolecule metabolic process (GO:0044036)	3.15781336
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15059057
38	fusion of sperm to egg plasma membrane (GO:0007342)	3.14619692
39	mitotic sister chromatid cohesion (GO:0007064)	3.10473622
40	negative regulation of DNA repair (GO:0045738)	3.10301053
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10224376
42	meiotic chromosome segregation (GO:0045132)	3.10205663
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.08220304
44	attachment of spindle microtubules to kinetochore (GO:0008608)	3.05798328
45	histone H3-K9 demethylation (GO:0033169)	3.02986912
46	negative regulation of inclusion body assembly (GO:0090084)	2.98048712
47	viral transcription (GO:0019083)	2.93546751
48	translational termination (GO:0006415)	2.90881392
49	maturation of 5.8S rRNA (GO:0000460)	2.89945088
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.86920255
51	regulation of mitotic spindle checkpoint (GO:1903504)	2.86920255
52	nuclear pore complex assembly (GO:0051292)	2.83681479
53	photoreceptor cell maintenance (GO:0045494)	2.83644731
54	oxygen transport (GO:0015671)	2.81187122
55	nuclear pore organization (GO:0006999)	2.80525326
56	reproductive system development (GO:0061458)	2.80355246
57	spliceosomal snRNP assembly (GO:0000387)	2.79812106
58	centriole replication (GO:0007099)	2.79671920
59	otic vesicle formation (GO:0030916)	2.78396680
60	regulation of centriole replication (GO:0046599)	2.77012672
61	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.74694461
62	CENP-A containing nucleosome assembly (GO:0034080)	2.74364770
63	regulation of microtubule-based movement (GO:0060632)	2.73600428
64	protein targeting to Golgi (GO:0000042)	2.73337075
65	genitalia morphogenesis (GO:0035112)	2.72891421
66	artery smooth muscle contraction (GO:0014824)	2.71305668
67	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.70829729
68	negative regulation of gene silencing (GO:0060969)	2.68936107
69	replication fork processing (GO:0031297)	2.62258366
70	chromatin remodeling at centromere (GO:0031055)	2.62058475
71	negative regulation of appetite (GO:0032099)	2.61798560
72	negative regulation of response to food (GO:0032096)	2.61798560
73	establishment of protein localization to Golgi (GO:0072600)	2.60682367
74	DNA packaging (GO:0006323)	2.59850798
75	DNA alkylation (GO:0006305)	2.58839237
76	DNA methylation (GO:0006306)	2.58839237
77	chromosome organization (GO:0051276)	2.57745473
78	male gamete generation (GO:0048232)	2.54999110
79	germ cell development (GO:0007281)	2.54640332
80	spermatogenesis (GO:0007283)	2.54140647
81	gamete generation (GO:0007276)	2.51898448
82	kinetochore organization (GO:0051383)	2.51181250
83	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.50574885
84	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.50574885
85	isotype switching (GO:0045190)	2.50574885
86	acrosome reaction (GO:0007340)	2.50022895
87	striatum development (GO:0021756)	2.48932402
88	intracellular protein transmembrane import (GO:0044743)	2.48869108
89	regulation of glucokinase activity (GO:0033131)	2.48735970
90	regulation of hexokinase activity (GO:1903299)	2.48735970
91	DNA biosynthetic process (GO:0071897)	2.48154982
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.47894137
93	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.46454974
94	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.46454974
95	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.46454974
96	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.46454974
97	negative regulation of sister chromatid segregation (GO:0033046)	2.46454974
98	regulation of meiotic cell cycle (GO:0051445)	2.45312244
99	DNA ligation (GO:0006266)	2.41741747
100	synapsis (GO:0007129)	12.6761887

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.35955888
2	VDR_22108803_ChIP-Seq_LS180_Human	3.34414365
3	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.23465497
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03295589
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.86450690
6	FUS_26573619_Chip-Seq_HEK293_Human	2.85387526
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77499187
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75066946
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69681167
10	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.62303568
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.62098912
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60455957
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.59993436
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.59518256
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.56189242
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.43760163
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.26152105
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.08684772
19	EWS_26573619_Chip-Seq_HEK293_Human	1.95102607
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.89995725
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86720577
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86629060
23	E2F7_22180533_ChIP-Seq_HELA_Human	1.76140402
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.73246935
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71416712
26	RNF2_27304074_Chip-Seq_NSC_Mouse	1.70674559
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65789903
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.62443238
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.61947058
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61769949
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.51519666
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51296247
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.49941909
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48708701
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.48100710
36	P300_19829295_ChIP-Seq_ESCs_Human	1.46330442
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.45552843
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43374292
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42188260
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.42019673
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41981537
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.41093190
43	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.36804156
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.36070740
45	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.34506774
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.33165431
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.32168472
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31859141
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31507532
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29108257
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27801745
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25785085
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24759014
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.24584041
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24491470
56	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24483401
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24085021
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24085021
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23944046
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.23781368
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23781368
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23760289
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21454593
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21208150
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.19044969
66	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.18033338
67	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17291387
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17202113
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17052372
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16089701
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15939585
72	AR_25329375_ChIP-Seq_VCAP_Human	1.15933873
73	AR_20517297_ChIP-Seq_VCAP_Human	1.13436537
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13358231
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13358231
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11109300
77	TAF15_26573619_Chip-Seq_HEK293_Human	1.10352763
78	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09988341
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.09832801
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08926327
81	ERA_21632823_ChIP-Seq_H3396_Human	1.08545378
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08185918
83	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.07043796
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06923540
85	NCOR_22424771_ChIP-Seq_293T_Human	1.06861214
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06837144
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04204523
88	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04080860
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02823123
90	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02158875
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99950443
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.99819645
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99649274
94	TCF4_23295773_ChIP-Seq_U87_Human	0.99596558
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.98931116
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97861148
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97123815
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96860100
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.95090617
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94856282

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.71461381
2	MP0009379_abnormal_foot_pigmentation	3.97985743
3	MP0003136_yellow_coat_color	3.76821612
4	MP0006292_abnormal_olfactory_placode	3.75440625
5	MP0002160_abnormal_reproductive_system	3.66186933
6	MP0008004_abnormal_stomach_pH	2.90691738
7	MP0002210_abnormal_sex_determination	2.81375708
8	MP0008058_abnormal_DNA_repair	2.67230036
9	MP0009697_abnormal_copulation	2.64892407
10	MP0001188_hyperpigmentation	2.55427896
11	MP0001929_abnormal_gametogenesis	2.41350030
12	MP0005389_reproductive_system_phenotype	2.35526750
13	MP0000372_irregular_coat_pigmentation	2.28080580
14	MP0003698_abnormal_male_reproductive	2.24422796
15	MP0001661_extended_life_span	2.11826837
16	MP0005410_abnormal_fertilization	2.10528893
17	MP0000653_abnormal_sex_gland	2.01112598
18	MP0001145_abnormal_male_reproductive	1.96721178
19	MP0003693_abnormal_embryo_hatching	1.95539427
20	MP0003890_abnormal_embryonic-extraembry	1.94069677
21	MP0001485_abnormal_pinna_reflex	1.91442336
22	MP0000383_abnormal_hair_follicle	1.89664192
23	MP0004885_abnormal_endolymph	1.87390644
24	MP0008995_early_reproductive_senescence	1.86612917
25	MP0000427_abnormal_hair_cycle	1.86269606
26	MP0004147_increased_porphyrin_level	1.78552232
27	MP0002095_abnormal_skin_pigmentation	1.76998619
28	MP0002254_reproductive_system_inflammat	1.68826172
29	MP0005275_abnormal_skin_tensile	1.68105083
30	MP0000579_abnormal_nail_morphology	1.67659255
31	MP0003718_maternal_effect	1.66975716
32	MP0003315_abnormal_perineum_morphology	1.65079146
33	MP0002277_abnormal_respiratory_mucosa	1.64908712
34	MP0003806_abnormal_nucleotide_metabolis	1.51301828
35	MP0003941_abnormal_skin_development	1.48915331
36	MP0006276_abnormal_autonomic_nervous	1.48776354
37	MP0004957_abnormal_blastocyst_morpholog	1.47322500
38	MP0000647_abnormal_sebaceous_gland	1.46291097
39	MP0001119_abnormal_female_reproductive	1.45686739
40	MP0004742_abnormal_vestibular_system	1.38944680
41	MP0005187_abnormal_penis_morphology	1.36554730
42	MP0003567_abnormal_fetal_cardiomyocyte	1.32945419
43	MP0001293_anophthalmia	1.28706686
44	MP0002102_abnormal_ear_morphology	1.27714059
45	MP0003878_abnormal_ear_physiology	1.26208313
46	MP0005377_hearing/vestibular/ear_phenot	1.26208313
47	MP0001984_abnormal_olfaction	1.25151663
48	MP0003786_premature_aging	1.18293721
49	MP0000631_abnormal_neuroendocrine_gland	1.17600835
50	MP0002161_abnormal_fertility/fecundity	1.12930071
51	MP0010094_abnormal_chromosome_stability	1.12551597
52	MP0010678_abnormal_skin_adnexa	1.10654573
53	MP0001529_abnormal_vocalization	1.07857375
54	MP0002132_abnormal_respiratory_system	1.06479563
55	MP0009250_abnormal_appendicular_skeleto	1.03676128
56	MP0003699_abnormal_female_reproductive	1.03017701
57	MP0003937_abnormal_limbs/digits/tail_de	0.99671316
58	MP0003123_paternal_imprinting	0.96537140
59	MP0004381_abnormal_hair_follicle	0.95410545
60	MP0003011_delayed_dark_adaptation	0.95152951
61	MP0002282_abnormal_trachea_morphology	0.94523078
62	MP0008057_abnormal_DNA_replication	0.94177211
63	MP0002249_abnormal_larynx_morphology	0.93570873
64	MP0005310_abnormal_salivary_gland	0.92486784
65	MP0004043_abnormal_pH_regulation	0.89578039
66	MP0005075_abnormal_melanosome_morpholog	0.88812450
67	MP0004019_abnormal_vitamin_homeostasis	0.88712268
68	MP0004142_abnormal_muscle_tone	0.87973838
69	MP0006054_spinal_hemorrhage	0.86988370
70	MP0002163_abnormal_gland_morphology	0.85806649
71	MP0003950_abnormal_plasma_membrane	0.83017123
72	MP0000049_abnormal_middle_ear	0.80146403
73	MP0005551_abnormal_eye_electrophysiolog	0.79562228
74	MP0003111_abnormal_nucleus_morphology	0.78295938
75	MP0004133_heterotaxia	0.77329274
76	MP0008007_abnormal_cellular_replicative	0.74162024
77	MP0005670_abnormal_white_adipose	0.73395050
78	MP0000778_abnormal_nervous_system	0.73041390
79	MP0001881_abnormal_mammary_gland	0.72814016
80	MP0009703_decreased_birth_body	0.71454437
81	MP0003283_abnormal_digestive_organ	0.70860522
82	MP0001697_abnormal_embryo_size	0.70289324
83	MP0002084_abnormal_developmental_patter	0.69641424
84	MP0001501_abnormal_sleep_pattern	0.67855459
85	MP0001486_abnormal_startle_reflex	0.66152137
86	MP0001666_abnormal_nutrient_absorption	0.65207911
87	MP0001919_abnormal_reproductive_system	0.64387611
88	MP0003936_abnormal_reproductive_system	0.64367589
89	MP0005646_abnormal_pituitary_gland	0.63910192
90	MP0000537_abnormal_urethra_morphology	0.63618695
91	MP0000358_abnormal_cell_content/	0.63582819
92	MP0001286_abnormal_eye_development	0.63096867
93	MP0001963_abnormal_hearing_physiology	0.61769499
94	MP0003938_abnormal_ear_development	0.61751921
95	MP0000678_abnormal_parathyroid_gland	0.60481059
96	MP0010352_gastrointestinal_tract_polyps	0.59041611
97	MP0008872_abnormal_physiological_respon	0.58397576
98	MP0000026_abnormal_inner_ear	0.57506131
99	MP0003137_abnormal_impulse_conducting	0.56993259
100	MP0002109_abnormal_limb_morphology	0.53470058

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.98447001
2	Oligodactyly (hands) (HP:0001180)	4.89292949
3	Reticulocytopenia (HP:0001896)	4.79633190
4	Volvulus (HP:0002580)	3.75276168
5	Abnormal hemoglobin (HP:0011902)	3.65331740
6	Pili torti (HP:0003777)	3.45655765
7	Azoospermia (HP:0000027)	3.43719369
8	Shoulder girdle muscle weakness (HP:0003547)	3.39383580
9	Ectopic kidney (HP:0000086)	3.36232161
10	Molar tooth sign on MRI (HP:0002419)	3.25357810
11	Abnormality of midbrain morphology (HP:0002418)	3.25357810
12	Hyperglycinemia (HP:0002154)	3.01114574
13	Acute encephalopathy (HP:0006846)	2.97104532
14	Oligodactyly (HP:0012165)	2.94248912
15	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.89768118
16	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.89768118
17	Rimmed vacuoles (HP:0003805)	2.88200769
18	Abnormality of alanine metabolism (HP:0010916)	2.85712941
19	Hyperalaninemia (HP:0003348)	2.85712941
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.85712941
21	Pallor (HP:0000980)	2.75995467
22	Hyperglycinuria (HP:0003108)	2.74051592
23	Abnormality of the renal cortex (HP:0011035)	2.69392062
24	Follicular hyperkeratosis (HP:0007502)	2.68575856
25	Partial duplication of thumb phalanx (HP:0009944)	2.67478335
26	Chronic hepatic failure (HP:0100626)	2.66111974
27	Methylmalonic acidemia (HP:0002912)	2.62129787
28	Abnormality of the labia minora (HP:0012880)	2.53600340
29	Medial flaring of the eyebrow (HP:0010747)	2.51074475
30	Acute necrotizing encephalopathy (HP:0006965)	2.50504982
31	Decreased central vision (HP:0007663)	2.47278932
32	Abnormal spermatogenesis (HP:0008669)	2.44434338
33	Abnormality of glycine metabolism (HP:0010895)	2.43633010
34	Abnormality of serine family amino acid metabolism (HP:0010894)	2.43633010
35	Abnormality of the renal medulla (HP:0100957)	2.38201359
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.33728369
37	Congenital primary aphakia (HP:0007707)	2.32049986
38	Partial duplication of the phalanx of hand (HP:0009999)	2.31037007
39	Maternal diabetes (HP:0009800)	2.30536037
40	Duplication of thumb phalanx (HP:0009942)	2.27612852
41	Poor coordination (HP:0002370)	2.27288741
42	Abnormality of the renal collecting system (HP:0004742)	2.24074878
43	Nephronophthisis (HP:0000090)	2.23940755
44	Pancreatic fibrosis (HP:0100732)	2.23298490
45	Nephrogenic diabetes insipidus (HP:0009806)	2.19840039
46	Chromsome breakage (HP:0040012)	2.18212057
47	Duplicated collecting system (HP:0000081)	2.18104791
48	Gait imbalance (HP:0002141)	2.17383560
49	Occipital encephalocele (HP:0002085)	2.16986186
50	Abnormality of chromosome stability (HP:0003220)	2.16968746
51	Optic nerve hypoplasia (HP:0000609)	2.16442759
52	Progressive macrocephaly (HP:0004481)	2.13829994
53	Abnormality of the corticospinal tract (HP:0002492)	2.11664635
54	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11220910
55	Septo-optic dysplasia (HP:0100842)	2.09532200
56	Absent thumb (HP:0009777)	2.08422325
57	Macrocytic anemia (HP:0001972)	2.08031486
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06678745
59	Abnormal number of erythroid precursors (HP:0012131)	2.05539065
60	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.05438128
61	Amyotrophic lateral sclerosis (HP:0007354)	2.05434472
62	Woolly hair (HP:0002224)	2.04923147
63	Colon cancer (HP:0003003)	2.03646258
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03510588
65	Delayed CNS myelination (HP:0002188)	1.98850963
66	3-Methylglutaconic aciduria (HP:0003535)	1.95827742
67	Abnormality of serum amino acid levels (HP:0003112)	1.94802861
68	Abnormality of vitamin B metabolism (HP:0004340)	1.93276569
69	Hypoplasia of the radius (HP:0002984)	1.93117703
70	Abnormality of hair growth rate (HP:0011363)	1.92916992
71	Slow-growing hair (HP:0002217)	1.92916992
72	Type II lissencephaly (HP:0007260)	1.91759068
73	Respiratory difficulties (HP:0002880)	1.90474672
74	Optic nerve coloboma (HP:0000588)	1.90069855
75	Pancreatic cysts (HP:0001737)	1.89650890
76	Small intestinal stenosis (HP:0012848)	1.87945230
77	Duodenal stenosis (HP:0100867)	1.87945230
78	Capillary hemangiomas (HP:0005306)	1.86958805
79	Lipid accumulation in hepatocytes (HP:0006561)	1.86847080
80	Oculomotor apraxia (HP:0000657)	1.86523696
81	Increased CSF lactate (HP:0002490)	1.86023128
82	Meckel diverticulum (HP:0002245)	1.84779587
83	Abnormality of the preputium (HP:0100587)	1.83944406
84	Abnormality of vitamin metabolism (HP:0100508)	1.83894069
85	Congenital stationary night blindness (HP:0007642)	1.83667976
86	Gonadotropin excess (HP:0000837)	1.82418700
87	Neoplasm of the tracheobronchial system (HP:0100552)	1.82184815
88	Abnormality of the ileum (HP:0001549)	1.82065066
89	Alveolar cell carcinoma (HP:0006519)	1.80748406
90	Oral leukoplakia (HP:0002745)	1.80149511
91	Bile duct proliferation (HP:0001408)	1.79420470
92	Abnormal biliary tract physiology (HP:0012439)	1.79420470
93	Acanthocytosis (HP:0001927)	1.78517874
94	Cerebral edema (HP:0002181)	1.78384740
95	Genital tract atresia (HP:0001827)	1.78362057
96	True hermaphroditism (HP:0010459)	1.77978814
97	Mitochondrial inheritance (HP:0001427)	1.76330427
98	Truncal obesity (HP:0001956)	1.75020305
99	Sparse eyelashes (HP:0000653)	1.74333041
100	Renal cortical cysts (HP:0000803)	1.72107328

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	5.66619494
2	PNCK	4.61007333
3	STK38L	3.00250392
4	BRAF	2.90659201
5	PLK4	2.52973410
6	PDK2	2.46085566
7	NME1	2.37428921
8	ZAK	2.36525099
9	CDK19	2.20381201
10	EIF2AK3	2.16343454
11	TNIK	2.15599485
12	WNK4	2.05724249
13	OXSR1	1.96592565
14	LATS1	1.89603805
15	NLK	1.87467076
16	TAF1	1.78486796
17	PINK1	1.75010603
18	WNK3	1.71696419
19	TTK	1.70367103
20	RPS6KA4	1.65338812
21	BUB1	1.59937520
22	NUAK1	1.59602754
23	DYRK2	1.55989547
24	BRD4	1.52004076
25	CDK3	1.44875257
26	PBK	1.41406630
27	MET	1.39530935
28	STK3	1.34021021
29	WEE1	1.25087384
30	STK39	1.23346084
31	FRK	1.19604751
32	CDC7	1.17919279
33	BMPR1B	1.15923124
34	PLK2	1.13239225
35	VRK2	1.11233157
36	MKNK2	1.04978013
37	CAMK1G	1.00266624
38	SGK2	0.98132156
39	WNK1	0.97920830
40	MST1R	0.97883261
41	MST4	0.92670715
42	ADRBK2	0.90304150
43	SGK223	0.90096561
44	SGK494	0.90096561
45	DYRK3	0.88743607
46	INSRR	0.86167979
47	VRK1	0.86150308
48	BMX	0.84755935
49	GRK1	0.84229979
50	MAPKAPK3	0.83159359
51	PLK1	0.81040436
52	TRIM28	0.77059540
53	MAPK13	0.75130563
54	MAP3K4	0.73471391
55	SGK1	0.70454424
56	KSR1	0.69175704
57	ATM	0.67003497
58	CSNK2A2	0.64815209
59	NEK2	0.64590389
60	TYRO3	0.62573414
61	ERBB2	0.61064363
62	AURKB	0.61029014
63	RPS6KA5	0.59434047
64	PRKCI	0.59367098
65	CAMK1	0.59206821
66	CHEK1	0.58164433
67	MKNK1	0.55363904
68	GRK7	0.52299079
69	AURKA	0.51245542
70	CSNK1E	0.50572668
71	MAP3K13	0.50218115
72	NEK6	0.48730337
73	ATR	0.48223515
74	CHEK2	0.48161889
75	CSNK2A1	0.47304356
76	STK38	0.45647054
77	FGFR1	0.43797168
78	TIE1	0.42338691
79	MAP3K5	0.42126766
80	ADRBK1	0.41876777
81	NEK1	0.41857813
82	STK16	0.39161512
83	RPS6KB1	0.38015850
84	PLK3	0.37675017
85	BRSK2	0.36829817
86	PRKCE	0.35462053
87	FGFR3	0.34929087
88	TLK1	0.34437842
89	PTK2B	0.33195205
90	TAOK3	0.32329253
91	EIF2AK1	0.29148282
92	NTRK3	0.28648359
93	MAP3K2	0.28084472
94	PRKACB	0.25532749
95	CDK8	0.25520170
96	CDK1	0.23922273
97	PASK	0.23843952
98	PDGFRB	0.23398800
99	STK10	0.23253683
100	CDK2	0.23023842

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.88921131
2	Proteasome_Homo sapiens_hsa03050	3.61027652
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13151039
4	Mismatch repair_Homo sapiens_hsa03430	3.11371429
5	Homologous recombination_Homo sapiens_hsa03440	2.86749950
6	Parkinsons disease_Homo sapiens_hsa05012	2.65302790
7	RNA transport_Homo sapiens_hsa03013	2.56015132
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.54684430
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51037155
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.50723173
11	Basal transcription factors_Homo sapiens_hsa03022	2.36074958
12	Propanoate metabolism_Homo sapiens_hsa00640	2.09750965
13	RNA degradation_Homo sapiens_hsa03018	2.06979072
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.96793540
15	Huntingtons disease_Homo sapiens_hsa05016	1.94142145
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89050970
17	RNA polymerase_Homo sapiens_hsa03020	1.78291484
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.76029838
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74927278
20	Alzheimers disease_Homo sapiens_hsa05010	1.74732930
21	One carbon pool by folate_Homo sapiens_hsa00670	1.74560444
22	Spliceosome_Homo sapiens_hsa03040	1.72513391
23	Oocyte meiosis_Homo sapiens_hsa04114	1.67279956
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67145354
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.66918313
26	Butanoate metabolism_Homo sapiens_hsa00650	1.65574077
27	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.63822286
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.61729454
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.57286428
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.43029089
31	DNA replication_Homo sapiens_hsa03030	1.40969318
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.34325141
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28887495
34	Circadian rhythm_Homo sapiens_hsa04710	1.28732247
35	Olfactory transduction_Homo sapiens_hsa04740	1.24288170
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18892338
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.18764870
38	Protein export_Homo sapiens_hsa03060	1.14521736
39	Caffeine metabolism_Homo sapiens_hsa00232	1.11758792
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08660772
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08188000
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04634235
43	Cell cycle_Homo sapiens_hsa04110	1.03285969
44	Phenylalanine metabolism_Homo sapiens_hsa00360	1.03061682
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97025029
46	Sulfur metabolism_Homo sapiens_hsa00920	0.94367444
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93388084
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91424964
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86868136
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85446502
51	Purine metabolism_Homo sapiens_hsa00230	0.84591086
52	Phototransduction_Homo sapiens_hsa04744	0.83820617
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81674186
54	Regulation of autophagy_Homo sapiens_hsa04140	0.81557423
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.80733783
56	Retinol metabolism_Homo sapiens_hsa00830	0.77110519
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69331947
58	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.67761256
59	Glutathione metabolism_Homo sapiens_hsa00480	0.67343717
60	Metabolic pathways_Homo sapiens_hsa01100	0.66694475
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65332596
62	ABC transporters_Homo sapiens_hsa02010	0.62718392
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.61153766
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60115960
65	Peroxisome_Homo sapiens_hsa04146	0.59038507
66	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58545621
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58439399
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58371628
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55822413
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.55054267
71	Thyroid cancer_Homo sapiens_hsa05216	0.54511596
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.52590894
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.48106625
74	Base excision repair_Homo sapiens_hsa03410	0.47249224
75	Taste transduction_Homo sapiens_hsa04742	0.46855760
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.45994916
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45230870
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.44265928
79	Fatty acid degradation_Homo sapiens_hsa00071	0.41848282
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.41610450
81	Serotonergic synapse_Homo sapiens_hsa04726	0.37786064
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37471144
83	Nicotine addiction_Homo sapiens_hsa05033	0.37237728
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.35159097
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35107990
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34368126
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33131214
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32993053
89	Mineral absorption_Homo sapiens_hsa04978	0.31286359
90	Protein digestion and absorption_Homo sapiens_hsa04974	0.29049253
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28779191
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27866495
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27490262
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26181843
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24769107
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.23936646
97	Melanoma_Homo sapiens_hsa05218	0.22717924
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.21641926
99	p53 signaling pathway_Homo sapiens_hsa04115	0.21099670
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.19913673

CTAGE9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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