CTBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.70646034
2regulation of gene silencing by miRNA (GO:0060964)5.70646034
3regulation of gene silencing by RNA (GO:0060966)5.70646034
4paraxial mesoderm development (GO:0048339)4.69328893
5nuclear pore organization (GO:0006999)4.32793035
6DNA replication-dependent nucleosome assembly (GO:0006335)4.16041816
7DNA replication-dependent nucleosome organization (GO:0034723)4.16041816
8nuclear pore complex assembly (GO:0051292)4.15410443
9DNA unwinding involved in DNA replication (GO:0006268)4.14608445
10protein localization to kinetochore (GO:0034501)4.06114882
11pre-miRNA processing (GO:0031054)3.98962950
12mitotic metaphase plate congression (GO:0007080)3.96626225
13regulation of helicase activity (GO:0051095)3.86062186
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85115856
15negative regulation of histone methylation (GO:0031061)3.80723282
16DNA replication initiation (GO:0006270)3.76313791
17heterochromatin organization (GO:0070828)3.67070275
18regulation of histone H3-K9 methylation (GO:0051570)3.65087011
19mitotic nuclear envelope disassembly (GO:0007077)3.63991738
20convergent extension (GO:0060026)3.62847267
21establishment of integrated proviral latency (GO:0075713)3.55959829
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.54221575
23regulation of gene silencing (GO:0060968)3.51248441
24regulation of hippo signaling (GO:0035330)3.50971152
25positive regulation of SMAD protein import into nucleus (GO:0060391)3.41601389
26IMP biosynthetic process (GO:0006188)3.41320822
27metaphase plate congression (GO:0051310)3.40337428
28membrane disassembly (GO:0030397)3.39497762
29nuclear envelope disassembly (GO:0051081)3.39497762
30viral transcription (GO:0019083)3.36498460
31regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.36054567
32translational termination (GO:0006415)3.35245527
33folic acid-containing compound biosynthetic process (GO:0009396)3.34299456
34formation of translation preinitiation complex (GO:0001731)3.32419453
35protein localization to chromosome, centromeric region (GO:0071459)3.31787173
36ribosomal small subunit biogenesis (GO:0042274)3.30048261
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.27510447
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27510447
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.26958241
40regulation of cell fate specification (GO:0042659)3.21610122
41DNA strand elongation involved in DNA replication (GO:0006271)3.20400844
42mitotic sister chromatid segregation (GO:0000070)3.20317755
43lateral sprouting from an epithelium (GO:0060601)3.18221792
44establishment of apical/basal cell polarity (GO:0035089)3.13400281
45histone arginine methylation (GO:0034969)3.12727906
46chromatin assembly (GO:0031497)3.12453106
47DNA geometric change (GO:0032392)3.11323092
48DNA duplex unwinding (GO:0032508)3.11258245
49protein K6-linked ubiquitination (GO:0085020)3.09072659
50nucleobase biosynthetic process (GO:0046112)3.08063030
51protein complex localization (GO:0031503)3.07279966
52DNA replication checkpoint (GO:0000076)3.07185899
53apical protein localization (GO:0045176)3.04180666
54DNA strand elongation (GO:0022616)3.03939187
55peptidyl-arginine omega-N-methylation (GO:0035247)3.02813009
56histone H2A monoubiquitination (GO:0035518)3.01278108
57dosage compensation (GO:0007549)3.00325595
58pore complex assembly (GO:0046931)2.99075286
59sister chromatid segregation (GO:0000819)2.98716688
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.98670368
61IMP metabolic process (GO:0046040)2.98370618
62regulation of sister chromatid cohesion (GO:0007063)2.97016182
63regulation of SMAD protein import into nucleus (GO:0060390)2.96983984
64regulation of telomere maintenance via telomerase (GO:0032210)2.96935022
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.96504694
66establishment of chromosome localization (GO:0051303)2.93933478
67negative regulation of gene silencing (GO:0060969)2.93684167
68histone H4-K12 acetylation (GO:0043983)2.91640935
69notochord development (GO:0030903)2.89519228
70chromatin remodeling at centromere (GO:0031055)2.89395293
71ribosomal small subunit assembly (GO:0000028)2.89113332
72maturation of SSU-rRNA (GO:0030490)2.89061680
73kinetochore organization (GO:0051383)2.87861042
74mitotic chromosome condensation (GO:0007076)2.85788428
75ribosome assembly (GO:0042255)2.83942783
76ribosome biogenesis (GO:0042254)2.83644096
77embryonic body morphogenesis (GO:0010172)2.81900208
78regulation of establishment of planar polarity (GO:0090175)2.81552138
79establishment of tissue polarity (GO:0007164)2.80622253
80establishment of planar polarity (GO:0001736)2.80622253
81chromatin assembly or disassembly (GO:0006333)2.80593172
82negative regulation of chromosome segregation (GO:0051985)2.80185062
83anterior/posterior axis specification, embryo (GO:0008595)2.78483638
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78471385
85cellular protein complex localization (GO:0034629)2.78436590
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78266069
87establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.78263801
88positive regulation of chromosome segregation (GO:0051984)2.77736313
89hippo signaling (GO:0035329)2.77359237
90nodal signaling pathway (GO:0038092)2.75355867
91regulation of spindle organization (GO:0090224)2.75160235
92regulation of mitotic spindle organization (GO:0060236)2.74989065
93kinetochore assembly (GO:0051382)2.74733978
94DNA replication-independent nucleosome assembly (GO:0006336)2.74167424
95DNA replication-independent nucleosome organization (GO:0034724)2.74167424
96prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.74062604
97maturation of 5.8S rRNA (GO:0000460)2.73737245
98outer ear morphogenesis (GO:0042473)2.73640187
99trophectodermal cell differentiation (GO:0001829)2.73463545
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72245546
101dorsal/ventral axis specification (GO:0009950)2.70007145
102establishment or maintenance of monopolar cell polarity (GO:0061339)2.70006386
103establishment of monopolar cell polarity (GO:0061162)2.70006386
104telomere maintenance via semi-conservative replication (GO:0032201)2.69804667
105negative regulation of androgen receptor signaling pathway (GO:0060766)2.69666490
106regulation of centrosome cycle (GO:0046605)2.69596119
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.68953593
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68953593
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68953593
110negative regulation of sister chromatid segregation (GO:0033046)2.68953593
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68828590
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.68828590
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68828590
114purine nucleobase biosynthetic process (GO:0009113)2.68545396
115lung-associated mesenchyme development (GO:0060484)2.68228726
116CENP-A containing nucleosome assembly (GO:0034080)2.68155361
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67084954
118regulation of translational fidelity (GO:0006450)2.66257442
119regulation of chromosome segregation (GO:0051983)2.66042526
120spindle checkpoint (GO:0031577)2.65557064
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65080689
122intra-S DNA damage checkpoint (GO:0031573)2.64614248
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64068828
124determination of adult lifespan (GO:0008340)2.63595732
125ribosomal large subunit biogenesis (GO:0042273)2.62923882
126mismatch repair (GO:0006298)2.62910667
127mitotic spindle checkpoint (GO:0071174)2.62894030
128spindle assembly checkpoint (GO:0071173)2.62819295
129branching involved in salivary gland morphogenesis (GO:0060445)2.62276221
130peptidyl-arginine methylation (GO:0018216)2.62191181
131non-canonical Wnt signaling pathway (GO:0035567)2.60798967
132G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60339274
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58729410
134cellular protein complex disassembly (GO:0043624)2.58343010
135cotranslational protein targeting to membrane (GO:0006613)2.57909987
136translational elongation (GO:0006414)2.57846086
137viral life cycle (GO:0019058)2.57404088
138L-serine metabolic process (GO:0006563)2.56669143
139histone exchange (GO:0043486)2.56618995
140negative regulation of cell fate commitment (GO:0010454)2.55320289
141regulation of stem cell maintenance (GO:2000036)2.53061696
142translational initiation (GO:0006413)2.52883502
143neural tube closure (GO:0001843)2.52716467
144protein targeting to ER (GO:0045047)2.52502650
145positive regulation of catenin import into nucleus (GO:0035413)2.51124004
146inner ear receptor cell development (GO:0060119)2.50354806
147bone trabecula formation (GO:0060346)2.49943762
148tube closure (GO:0060606)2.49536068
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.48703575
150regulation of translation, ncRNA-mediated (GO:0045974)2.48703575
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48703575
152artery development (GO:0060840)2.48683859
153mitotic sister chromatid cohesion (GO:0007064)2.47523786
154negative regulation of keratinocyte proliferation (GO:0010839)2.47305157
155asymmetric protein localization (GO:0008105)2.46156217
156establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44809593
157protein complex disassembly (GO:0043241)2.42642957
158establishment of viral latency (GO:0019043)2.40182104
159ATP-dependent chromatin remodeling (GO:0043044)2.39619451
160establishment or maintenance of bipolar cell polarity (GO:0061245)2.39156030
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.39156030
162negative regulation of cell fate specification (GO:0009996)2.36996826
163chaperone-mediated protein transport (GO:0072321)2.35266385
164cell fate commitment involved in formation of primary germ layer (GO:0060795)2.34645937
165body morphogenesis (GO:0010171)2.32291811
166presynaptic membrane assembly (GO:0097105)2.30340877
167axon extension involved in axon guidance (GO:0048846)2.29701031
168neuron projection extension involved in neuron projection guidance (GO:1902284)2.29701031
169regulation of catenin import into nucleus (GO:0035412)2.29283566
170protein localization to endoplasmic reticulum (GO:0070972)2.28377484
171establishment of protein localization to mitochondrial membrane (GO:0090151)2.27468244
172cochlea morphogenesis (GO:0090103)2.26740606
173tight junction assembly (GO:0070830)2.25902446
174macromolecular complex disassembly (GO:0032984)2.25421815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.03525008
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.27075616
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.78041203
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.56545922
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.56545922
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.56545922
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42980058
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11941603
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08497621
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92789188
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.91605273
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79704883
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.64294268
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59015047
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.38128368
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36701020
17NANOG_18555785_ChIP-Seq_MESCs_Mouse2.31537849
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25209255
19* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.23761431
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22185013
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.21078070
22SOX2_18555785_ChIP-Seq_MESCs_Mouse2.19168755
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16757254
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15114838
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13666087
26* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.13068017
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.10630224
28TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09979729
29POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08584148
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06892560
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.05758858
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.04939484
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.97037738
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93191632
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90503077
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89312342
37* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.88310297
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.79918753
39XRN2_22483619_ChIP-Seq_HELA_Human1.77339822
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.77061626
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74270844
42AR_21909140_ChIP-Seq_LNCAP_Human1.71448342
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71115864
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.63566114
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63559515
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62343483
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.61806362
48* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.60888467
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57586585
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57325260
51* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54735559
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53128337
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51790503
54* TTF2_22483619_ChIP-Seq_HELA_Human1.51498790
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.50136083
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45131973
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.44343810
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43193360
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38919250
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36331827
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35233723
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35221003
63* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34382932
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33474010
65* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32594253
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31523555
67* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30746643
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28130909
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27341909
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26648362
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25224898
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24694138
73MYC_22102868_ChIP-Seq_BL_Human1.24243502
74DCP1A_22483619_ChIP-Seq_HELA_Human1.23957176
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23897378
76* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23643066
77* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23054124
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.22228914
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21749420
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20992594
81* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20840867
82* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20478703
83* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20311293
84* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19679470
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19152446
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18130290
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.18039017
88KDM5A_27292631_Chip-Seq_BREAST_Human1.17193549
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.16338935
90CIITA_25753668_ChIP-Seq_RAJI_Human1.15644444
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14320029
92VDR_23849224_ChIP-Seq_CD4+_Human1.14206772
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14188715
94GABP_19822575_ChIP-Seq_HepG2_Human1.11807547
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09190470
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08917372
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08393597
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08390752
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.08367407
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07794585
101* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06858904
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06624748
103FOXP3_21729870_ChIP-Seq_TREG_Human1.06364666
104CHD1_26751641_Chip-Seq_LNCaP_Human1.05401456
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.05331477
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.03953686
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02723042
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02337389
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01692533
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.01544448
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00133688
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99680806
113* EWS_26573619_Chip-Seq_HEK293_Human0.99461946
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98473970
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95796446
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.95411656
117* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94945246
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94706470
119TFEB_21752829_ChIP-Seq_HELA_Human0.94488682
120KAP1_27257070_Chip-Seq_ESCs_Mouse0.93855361
121* FUS_26573619_Chip-Seq_HEK293_Human0.93549703
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91710044
123ELK1_19687146_ChIP-ChIP_HELA_Human0.91702171
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91631776
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91107698
126* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89964121
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89492697
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89389387
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89228269
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89197627
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89085943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.36093080
2MP0003693_abnormal_embryo_hatching3.29784557
3MP0004957_abnormal_blastocyst_morpholog3.28235992
4MP0010094_abnormal_chromosome_stability3.05794253
5MP0010030_abnormal_orbit_morphology2.95902070
6MP0009379_abnormal_foot_pigmentation2.94471554
7MP0008057_abnormal_DNA_replication2.92296929
8MP0003077_abnormal_cell_cycle2.81953078
9MP0002653_abnormal_ependyma_morphology2.78698306
10MP0000566_synostosis2.75143267
11MP0010352_gastrointestinal_tract_polyps2.51255467
12MP0003123_paternal_imprinting2.49254533
13MP0000579_abnormal_nail_morphology2.31019190
14MP0006292_abnormal_olfactory_placode2.23206438
15MP0003890_abnormal_embryonic-extraembry2.21368558
16MP0008058_abnormal_DNA_repair2.17546852
17MP0006072_abnormal_retinal_apoptosis2.13703129
18MP0004133_heterotaxia2.12031020
19MP0000350_abnormal_cell_proliferation2.04880989
20MP0001730_embryonic_growth_arrest1.96839423
21MP0003119_abnormal_digestive_system1.94707999
22MP0005076_abnormal_cell_differentiation1.94325698
23MP0008932_abnormal_embryonic_tissue1.93462325
24MP0008007_abnormal_cellular_replicative1.92941750
25MP0002084_abnormal_developmental_patter1.92769891
26MP0001188_hyperpigmentation1.92080823
27MP0003121_genomic_imprinting1.91096726
28* MP0002085_abnormal_embryonic_tissue1.89792216
29MP0001293_anophthalmia1.86948493
30MP0005380_embryogenesis_phenotype1.86642039
31MP0001672_abnormal_embryogenesis/_devel1.86642039
32MP0003941_abnormal_skin_development1.78071152
33MP0003705_abnormal_hypodermis_morpholog1.77913911
34MP0000537_abnormal_urethra_morphology1.71879593
35* MP0001697_abnormal_embryo_size1.68045881
36MP0003984_embryonic_growth_retardation1.64680217
37MP0004197_abnormal_fetal_growth/weight/1.64099628
38MP0002088_abnormal_embryonic_growth/wei1.63368586
39MP0003011_delayed_dark_adaptation1.53661317
40* MP0002086_abnormal_extraembryonic_tissu1.52562907
41MP0005253_abnormal_eye_physiology1.50924434
42MP0000778_abnormal_nervous_system1.47934304
43MP0003283_abnormal_digestive_organ1.44251698
44MP0008877_abnormal_DNA_methylation1.41487201
45MP0002796_impaired_skin_barrier1.40587548
46MP0002938_white_spotting1.36590733
47MP0010307_abnormal_tumor_latency1.35768471
48MP0003937_abnormal_limbs/digits/tail_de1.35442190
49MP0000516_abnormal_urinary_system1.35054830
50MP0005367_renal/urinary_system_phenotyp1.35054830
51MP0005551_abnormal_eye_electrophysiolog1.34751602
52* MP0002080_prenatal_lethality1.34628370
53MP0005391_vision/eye_phenotype1.32301350
54MP0003567_abnormal_fetal_cardiomyocyte1.31850054
55MP0003950_abnormal_plasma_membrane1.31809315
56MP0003938_abnormal_ear_development1.31182016
57MP0008789_abnormal_olfactory_epithelium1.31074581
58MP0001286_abnormal_eye_development1.30321188
59MP0002697_abnormal_eye_size1.30084108
60MP0003786_premature_aging1.29286564
61MP0003718_maternal_effect1.28623617
62MP0003136_yellow_coat_color1.27835744
63MP0009053_abnormal_anal_canal1.27652539
64MP0009250_abnormal_appendicular_skeleto1.23432962
65MP0001849_ear_inflammation1.21289095
66MP0003315_abnormal_perineum_morphology1.19268140
67MP0001299_abnormal_eye_distance/1.18678934
68MP0002254_reproductive_system_inflammat1.17073633
69MP0005623_abnormal_meninges_morphology1.15995605
70MP0004233_abnormal_muscle_weight1.15846948
71MP0000490_abnormal_crypts_of1.14382102
72MP0005499_abnormal_olfactory_system1.11053270
73MP0005394_taste/olfaction_phenotype1.11053270
74MP0000049_abnormal_middle_ear1.08611369
75MP0002111_abnormal_tail_morphology1.08544342
76MP0000462_abnormal_digestive_system1.08108631
77MP0002092_abnormal_eye_morphology1.07379841
78MP0003566_abnormal_cell_adhesion1.06171625
79* MP0003861_abnormal_nervous_system1.05565208
80MP0000432_abnormal_head_morphology1.03677569
81MP0000428_abnormal_craniofacial_morphol1.03202790
82MP0003755_abnormal_palate_morphology1.02151437
83MP0001529_abnormal_vocalization1.01140704
84MP0004264_abnormal_extraembryonic_tissu0.98742635
85MP0002249_abnormal_larynx_morphology0.97979757
86MP0003935_abnormal_craniofacial_develop0.97655334
87MP0000313_abnormal_cell_death0.97516138
88MP0001485_abnormal_pinna_reflex0.97227706
89MP0005195_abnormal_posterior_eye0.96315006
90MP0005248_abnormal_Harderian_gland0.96127196
91MP0005409_darkened_coat_color0.95856935
92MP0005501_abnormal_skin_physiology0.93986171
93MP0004185_abnormal_adipocyte_glucose0.93780226
94MP0001915_intracranial_hemorrhage0.93657690
95MP0002210_abnormal_sex_determination0.93171204
96MP0009703_decreased_birth_body0.92477013
97MP0003122_maternal_imprinting0.92450956
98MP0003787_abnormal_imprinting0.90566185
99MP0002081_perinatal_lethality0.88821727
100* MP0002925_abnormal_cardiovascular_devel0.88086624
101MP0001340_abnormal_eyelid_morphology0.87857748
102MP0010678_abnormal_skin_adnexa0.86651674
103MP0003115_abnormal_respiratory_system0.86042831
104MP0000383_abnormal_hair_follicle0.86020357
105MP0001177_atelectasis0.85778336
106MP0001145_abnormal_male_reproductive0.82855342
107MP0005257_abnormal_intraocular_pressure0.82563015
108MP0002822_catalepsy0.81836727
109MP0003385_abnormal_body_wall0.81586430
110MP0002116_abnormal_craniofacial_bone0.81375027
111MP0000534_abnormal_ureter_morphology0.80988206
112MP0000467_abnormal_esophagus_morphology0.80786984
113MP0009278_abnormal_bone_marrow0.80367747
114MP0002233_abnormal_nose_morphology0.80099351
115MP0003942_abnormal_urinary_system0.80021425
116MP0009672_abnormal_birth_weight0.79653020
117MP0004272_abnormal_basement_membrane0.78865581
118MP0000631_abnormal_neuroendocrine_gland0.78847947
119MP0002282_abnormal_trachea_morphology0.78834820
120MP0000733_abnormal_muscle_development0.77938337
121MP0002932_abnormal_joint_morphology0.77882213
122MP0005508_abnormal_skeleton_morphology0.77798235
123MP0002751_abnormal_autonomic_nervous0.77576202
124MP0002098_abnormal_vibrissa_morphology0.77560265
125MP0010234_abnormal_vibrissa_follicle0.76318151
126MP0000762_abnormal_tongue_morphology0.75377561
127MP0005023_abnormal_wound_healing0.75225015
128MP0002127_abnormal_cardiovascular_syste0.74467844
129MP0002114_abnormal_axial_skeleton0.72116333

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.00166086
2Congenital stationary night blindness (HP:0007642)3.77908343
3Abnormality of the labia minora (HP:0012880)3.48706305
4Medulloblastoma (HP:0002885)3.29807904
5Supernumerary spleens (HP:0009799)3.29225247
6Pendular nystagmus (HP:0012043)3.28240714
7Selective tooth agenesis (HP:0001592)3.16043798
8Abnormality of abdominal situs (HP:0011620)3.08668123
9Abdominal situs inversus (HP:0003363)3.08668123
10Abnormality of the astrocytes (HP:0100707)3.06783547
11Astrocytoma (HP:0009592)3.06783547
12Bony spicule pigmentary retinopathy (HP:0007737)3.03214680
13Colon cancer (HP:0003003)2.97228736
14Absent radius (HP:0003974)2.96577419
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95666084
16Neoplasm of the oral cavity (HP:0100649)2.94671819
17Partial duplication of thumb phalanx (HP:0009944)2.89886840
18Chromsome breakage (HP:0040012)2.87701107
19Partial duplication of the phalanx of hand (HP:0009999)2.87389834
20Rib fusion (HP:0000902)2.80614766
21Aplasia involving forearm bones (HP:0009822)2.80045611
22Absent forearm bone (HP:0003953)2.80045611
23Abnormal number of incisors (HP:0011064)2.78616378
24Birth length less than 3rd percentile (HP:0003561)2.73518132
25Aplasia/hypoplasia of the humerus (HP:0006507)2.71682423
26Rhabdomyosarcoma (HP:0002859)2.64306152
27Short humerus (HP:0005792)2.61565397
28Chorioretinal atrophy (HP:0000533)2.61194001
29Glioma (HP:0009733)2.56090443
30Breast hypoplasia (HP:0003187)2.54843499
31Bilateral microphthalmos (HP:0007633)2.54416262
32Patellar aplasia (HP:0006443)2.53891065
33Esophageal atresia (HP:0002032)2.52763455
34Missing ribs (HP:0000921)2.49103610
35Rectal fistula (HP:0100590)2.49025740
36Rectovaginal fistula (HP:0000143)2.49025740
37Maternal diabetes (HP:0009800)2.48487264
38Coronal craniosynostosis (HP:0004440)2.47293564
39Shawl scrotum (HP:0000049)2.46746491
40Aplasia/Hypoplasia of the patella (HP:0006498)2.43072452
41Neoplasm of striated muscle (HP:0009728)2.41247138
42Abnormality of the phalanges of the hallux (HP:0010057)2.40404552
43Broad metatarsal (HP:0001783)2.36406838
44Hepatoblastoma (HP:0002884)2.35503971
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31017848
46Agnosia (HP:0010524)2.30224376
47Intestinal fistula (HP:0100819)2.29755472
48Abnormality of the lacrimal duct (HP:0011481)2.29641981
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.28528209
50Abnormal rod and cone electroretinograms (HP:0008323)2.25039837
51Shallow orbits (HP:0000586)2.25031158
52Duplication of thumb phalanx (HP:0009942)2.24888766
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24153730
54Cutaneous syndactyly (HP:0012725)2.23733519
55Absent thumb (HP:0009777)2.23697846
56Abnormal lung lobation (HP:0002101)2.23399766
57Absent septum pellucidum (HP:0001331)2.22459998
58Posterior subcapsular cataract (HP:0007787)2.20481322
59Myelomeningocele (HP:0002475)2.19945689
60Abnormality of the nasolacrimal system (HP:0000614)2.19515755
61Cutaneous finger syndactyly (HP:0010554)2.19172042
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.18331323
63Choanal stenosis (HP:0000452)2.17892185
64Meckel diverticulum (HP:0002245)2.17773657
65Septo-optic dysplasia (HP:0100842)2.15591434
66Scotoma (HP:0000575)2.14498869
67Preaxial foot polydactyly (HP:0001841)2.11786467
68Biliary tract neoplasm (HP:0100574)2.10679777
69Abnormality of the septum pellucidum (HP:0007375)2.10627848
70Malignant gastrointestinal tract tumors (HP:0006749)2.10087882
71Gastrointestinal carcinoma (HP:0002672)2.10087882
72Abnormality of the ileum (HP:0001549)2.10066000
73Cortical dysplasia (HP:0002539)2.08135433
74Reticulocytopenia (HP:0001896)2.08042357
75Abnormality of cells of the erythroid lineage (HP:0012130)2.07906981
76Aplasia involving bones of the extremities (HP:0009825)2.06014316
77Aplasia involving bones of the upper limbs (HP:0009823)2.06014316
78Aplasia of the phalanges of the hand (HP:0009802)2.06014316
79Tracheoesophageal fistula (HP:0002575)2.05703219
80Anal stenosis (HP:0002025)2.05441260
81Deviation of the thumb (HP:0009603)2.04484383
82Dyschromatopsia (HP:0007641)2.04443450
83Impulsivity (HP:0100710)2.04267560
84Abnormality of the anterior horn cell (HP:0006802)2.04230175
85Degeneration of anterior horn cells (HP:0002398)2.04230175
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.03966176
87Supernumerary bones of the axial skeleton (HP:0009144)2.01551151
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98527539
89Short 4th metacarpal (HP:0010044)1.98527539
90Supernumerary ribs (HP:0005815)1.98463620
91Gastrointestinal atresia (HP:0002589)1.97655744
92Proximal placement of thumb (HP:0009623)1.97595240
93Chronic bronchitis (HP:0004469)1.95522792
94Abnormality of the antihelix (HP:0009738)1.95476226
95Atresia of the external auditory canal (HP:0000413)1.94022031
96Bifid tongue (HP:0010297)1.93608393
97Vaginal fistula (HP:0004320)1.93128833
98Urethral obstruction (HP:0000796)1.92870287
99Oral leukoplakia (HP:0002745)1.92217856
100Abnormality of the aortic arch (HP:0012303)1.90518709
101Macrocytic anemia (HP:0001972)1.90221928
102High anterior hairline (HP:0009890)1.89696948
103Ectopic kidney (HP:0000086)1.89339147
104Severe visual impairment (HP:0001141)1.89200009
105Nephroblastoma (Wilms tumor) (HP:0002667)1.88991054
106Turricephaly (HP:0000262)1.88916161
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88685927
108Short 1st metacarpal (HP:0010034)1.88685927
109Anophthalmia (HP:0000528)1.88042785
110Short hallux (HP:0010109)1.87162977
111Abnormality of the preputium (HP:0100587)1.86872642
112Abnormality of chromosome stability (HP:0003220)1.86239664
113Vertebral arch anomaly (HP:0008438)1.85404902
114Neoplasm of the pancreas (HP:0002894)1.85385278
115Hemivertebrae (HP:0002937)1.85268396
116Facial cleft (HP:0002006)1.84722226
117Optic nerve hypoplasia (HP:0000609)1.84704496
118Abnormality of the parietal bone (HP:0002696)1.82481062
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.81834208
120Short phalanx of the thumb (HP:0009660)1.81534945
121Attenuation of retinal blood vessels (HP:0007843)1.81078932
122Breast aplasia (HP:0100783)1.80645417
123Intestinal atresia (HP:0011100)1.79629590
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78805535
125Morphological abnormality of the middle ear (HP:0008609)1.78606683
126Fused cervical vertebrae (HP:0002949)1.78590304
127Vertebral fusion (HP:0002948)1.78206706
128Trismus (HP:0000211)1.78163521
129Embryonal renal neoplasm (HP:0011794)1.76504922
130Carpal bone hypoplasia (HP:0001498)1.76293263
131Vertebral clefting (HP:0008428)1.75953135
132Small intestinal stenosis (HP:0012848)1.75648168
133Duodenal stenosis (HP:0100867)1.75648168
134Abnormality of permanent molar morphology (HP:0011071)1.75202074
135Abnormality of the dental root (HP:0006486)1.75202074
136Taurodontia (HP:0000679)1.75202074
137Stenosis of the external auditory canal (HP:0000402)1.75109771
138Short thumb (HP:0009778)1.74272287
139Increased nuchal translucency (HP:0010880)1.73543741
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.71962382
141Broad thumb (HP:0011304)1.71630081
142Vitreoretinal degeneration (HP:0000655)1.70227611
143Renal duplication (HP:0000075)1.70186054
144Abnormal number of erythroid precursors (HP:0012131)1.70002633
145Central scotoma (HP:0000603)1.69989024
146Skull defect (HP:0001362)1.69778662
147Rough bone trabeculation (HP:0100670)1.68357713
148Triphalangeal thumb (HP:0001199)1.66907027
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66037310
150Abnormality of the 4th metacarpal (HP:0010012)1.65723764
151Arnold-Chiari malformation (HP:0002308)1.64418439
152Nasolacrimal duct obstruction (HP:0000579)1.64267799
153Abnormality of molar (HP:0011077)1.64108071
154Abnormality of molar morphology (HP:0011070)1.64108071
155Bronchomalacia (HP:0002780)1.63663924
156Midline defect of the nose (HP:0004122)1.63414855
157Broad finger (HP:0001500)1.62490492
158Spastic diplegia (HP:0001264)1.60901352
159Abnormal vertebral ossification (HP:0100569)1.60797264
160Renal hypoplasia (HP:0000089)1.60540196
161Abnormality of the middle phalanges of the toes (HP:0010183)1.55122353
162Pterygium (HP:0001059)1.54730278
163Absent hair (HP:0002298)1.54459598
164Abnormality of the dental pulp (HP:0006479)1.54052016
165Abnormality of the incisor (HP:0000676)1.53974251
166Absent eyelashes (HP:0000561)1.53083478
167Long foot (HP:0001833)1.52111500
168Absent eyebrow (HP:0002223)1.50614106
169Broad phalanges of the hand (HP:0009768)1.50026823
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.48846242
171Vertebral hypoplasia (HP:0008417)1.48846242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.19532470
2CDK123.89080046
3CDC73.75183637
4WEE13.20499662
5TTK3.12369194
6BUB12.71044584
7TAF12.66313612
8NEK22.57644165
9NEK12.40977195
10SRPK12.29201469
11STK38L2.19419245
12RPS6KB22.12934954
13TNIK2.03227887
14CASK2.00330045
15PLK11.99638172
16CDK71.98660721
17LATS11.95943063
18VRK21.94052632
19BRD41.79294917
20TLK11.78079603
21LATS21.77049423
22PAK41.74641352
23DYRK31.72221998
24CHEK21.69011918
25DMPK1.63042347
26MAP3K91.58982235
27MKNK11.56863930
28ATR1.54903384
29PASK1.53987230
30PNCK1.47311541
31AURKB1.45956386
32TSSK61.43990917
33PLK31.42972614
34MKNK21.38604201
35CAMK1G1.37942961
36PKN21.37788287
37MST1R1.31952083
38AKT31.31378342
39CHEK11.31155759
40MAP3K101.26061680
41STK391.25738775
42CDK41.22681497
43MAP3K81.22600514
44AURKA1.22483860
45SCYL21.21418275
46TGFBR11.19203743
47STK241.09866616
48SMG11.08990804
49PLK41.08730894
50ATM1.06368306
51NTRK11.05759781
52CDK21.05231051
53ZAK1.04357708
54RPS6KA41.03612941
55ACVR1B1.03486954
56CAMK1D1.02705301
57ICK1.01715665
58ALK1.00463269
59GRK10.98490598
60CDK190.97184390
61SIK10.97130174
62MST40.95185859
63VRK10.94545617
64MTOR0.92077232
65PBK0.91517789
66EEF2K0.90233972
67STK100.89283129
68MAPK150.88627958
69NME10.87919664
70BRSK20.84318750
71CDK60.83327638
72STK30.81154485
73FLT30.80618827
74TESK20.76727046
75AKT20.76677413
76STK160.76332427
77BRAF0.75686864
78TRIB30.75108319
79TAOK20.74378764
80CDK10.73889549
81PRKCI0.73821939
82PDGFRA0.73219435
83KSR10.72879136
84MAP3K120.71445146
85MINK10.70502819
86STK40.70287225
87MELK0.69599450
88DYRK20.69424410
89FGFR20.67482505
90WNK30.67295076
91CDK30.66412547
92PIM10.65809047
93MAP2K20.65273030
94DDR20.65178886
95FGFR10.64834546
96PAK10.63900127
97MET0.63537770
98ARAF0.63379709
99RIPK10.62656717
100BMX0.61404534
101EIF2AK10.60957734
102PRKD30.60851949
103CSNK1E0.60123684
104RPS6KA20.59872701
105OXSR10.59734488
106CSNK1D0.59284655
107IRAK20.59193525
108MOS0.58919773
109CDK90.57686137
110BMPR1B0.57306187
111BRSK10.56907639
112PAK20.55418032
113ERBB40.55400881
114CSNK2A20.54175443
115PDGFRB0.52933739
116WNK40.52211285
117RPS6KL10.51121287
118RPS6KC10.51121287
119TYRO30.50760828
120AKT10.50528148
121MAP3K60.50153779
122ERBB30.50150626
123PRKDC0.49962890
124SGK4940.49574901
125SGK2230.49574901
126TTN0.48579981
127MAPK140.46969025
128CSNK2A10.46946847
129RPS6KA50.44188016
130CDK80.43881052
131BCR0.42749160
132RPS6KA60.42617539
133MAPK10.42551330
134STK380.42427377
135TESK10.42346411
136GSK3B0.41248060
137ERBB20.40968925
138MAPKAPK30.40846225
139EPHB20.40711609
140PTK20.39440633
141YES10.36167662
142PTK60.35751949
143NME20.35628669

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86185904
2Mismatch repair_Homo sapiens_hsa034303.84745006
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40844080
4Spliceosome_Homo sapiens_hsa030403.17748660
5RNA transport_Homo sapiens_hsa030133.15258416
6Phototransduction_Homo sapiens_hsa047442.83785553
7Cell cycle_Homo sapiens_hsa041102.67378638
8Base excision repair_Homo sapiens_hsa034102.67329600
9One carbon pool by folate_Homo sapiens_hsa006702.45301372
10Homologous recombination_Homo sapiens_hsa034402.42678797
11Nucleotide excision repair_Homo sapiens_hsa034202.40804702
12RNA polymerase_Homo sapiens_hsa030202.39455043
13mRNA surveillance pathway_Homo sapiens_hsa030152.39385391
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37931960
15Fanconi anemia pathway_Homo sapiens_hsa034602.21952775
16Ribosome_Homo sapiens_hsa030102.06669756
17RNA degradation_Homo sapiens_hsa030182.06595935
18Hippo signaling pathway_Homo sapiens_hsa043901.73118908
19Basal transcription factors_Homo sapiens_hsa030221.72412271
20Basal cell carcinoma_Homo sapiens_hsa052171.70850841
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66546677
22Pyrimidine metabolism_Homo sapiens_hsa002401.66014364
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62177508
24p53 signaling pathway_Homo sapiens_hsa041151.60096360
25Axon guidance_Homo sapiens_hsa043601.53212321
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52235465
27Huntingtons disease_Homo sapiens_hsa050161.45165051
28Systemic lupus erythematosus_Homo sapiens_hsa053221.38466900
29Non-homologous end-joining_Homo sapiens_hsa034501.35290069
30Adherens junction_Homo sapiens_hsa045201.32425512
31MicroRNAs in cancer_Homo sapiens_hsa052061.32333291
32TGF-beta signaling pathway_Homo sapiens_hsa043501.31689992
33Hedgehog signaling pathway_Homo sapiens_hsa043401.30027448
34Proteasome_Homo sapiens_hsa030501.27825201
35Oocyte meiosis_Homo sapiens_hsa041141.16417156
36Parkinsons disease_Homo sapiens_hsa050121.11402414
37Oxidative phosphorylation_Homo sapiens_hsa001901.09169377
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07105025
39Folate biosynthesis_Homo sapiens_hsa007901.06285841
40Viral carcinogenesis_Homo sapiens_hsa052031.05579223
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01411872
42Tight junction_Homo sapiens_hsa045300.99839712
43* Notch signaling pathway_Homo sapiens_hsa043300.99625712
44Colorectal cancer_Homo sapiens_hsa052100.99360698
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99138237
46Purine metabolism_Homo sapiens_hsa002300.98348622
47Cardiac muscle contraction_Homo sapiens_hsa042600.96313505
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95261163
49Vitamin B6 metabolism_Homo sapiens_hsa007500.94812657
50HTLV-I infection_Homo sapiens_hsa051660.94187935
51Thyroid cancer_Homo sapiens_hsa052160.93838433
52Small cell lung cancer_Homo sapiens_hsa052220.92371884
53Epstein-Barr virus infection_Homo sapiens_hsa051690.91549129
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.88891173
55mTOR signaling pathway_Homo sapiens_hsa041500.84607308
56Gap junction_Homo sapiens_hsa045400.83242090
57Alcoholism_Homo sapiens_hsa050340.80159649
58Bladder cancer_Homo sapiens_hsa052190.79512958
59Herpes simplex infection_Homo sapiens_hsa051680.78643306
60Alzheimers disease_Homo sapiens_hsa050100.77737440
61* Pathways in cancer_Homo sapiens_hsa052000.74718408
62ErbB signaling pathway_Homo sapiens_hsa040120.73925005
63* Wnt signaling pathway_Homo sapiens_hsa043100.72292171
64Steroid biosynthesis_Homo sapiens_hsa001000.70933370
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69533215
66Protein export_Homo sapiens_hsa030600.69231702
67Melanoma_Homo sapiens_hsa052180.68399482
68Cocaine addiction_Homo sapiens_hsa050300.66390493
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66225274
70Proteoglycans in cancer_Homo sapiens_hsa052050.65846110
71Endometrial cancer_Homo sapiens_hsa052130.64930812
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64318684
73HIF-1 signaling pathway_Homo sapiens_hsa040660.63284115
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62908509
75Fructose and mannose metabolism_Homo sapiens_hsa000510.62509241
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59203106
77Glutathione metabolism_Homo sapiens_hsa004800.57767666
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57711548
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56255905
80Vitamin digestion and absorption_Homo sapiens_hsa049770.55931027
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55468521
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55377460
83Estrogen signaling pathway_Homo sapiens_hsa049150.54408321
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53791698
85Pyruvate metabolism_Homo sapiens_hsa006200.53372995
86Galactose metabolism_Homo sapiens_hsa000520.50865226
87ECM-receptor interaction_Homo sapiens_hsa045120.50748497
88Prostate cancer_Homo sapiens_hsa052150.50382827
89Focal adhesion_Homo sapiens_hsa045100.49074873
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48521594
91Biosynthesis of amino acids_Homo sapiens_hsa012300.46124462
92Thyroid hormone synthesis_Homo sapiens_hsa049180.45805769
93Apoptosis_Homo sapiens_hsa042100.44897546
94Dopaminergic synapse_Homo sapiens_hsa047280.43393139
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43218535
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43096070
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42741859
98Lysine degradation_Homo sapiens_hsa003100.41974588
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41472962
100Viral myocarditis_Homo sapiens_hsa054160.41295250
101Long-term depression_Homo sapiens_hsa047300.39917503
102Glutamatergic synapse_Homo sapiens_hsa047240.38213209
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36306469
104Choline metabolism in cancer_Homo sapiens_hsa052310.36095950
105Legionellosis_Homo sapiens_hsa051340.35581456
106* Chronic myeloid leukemia_Homo sapiens_hsa052200.35253956
107Renal cell carcinoma_Homo sapiens_hsa052110.34295586
108Cholinergic synapse_Homo sapiens_hsa047250.34289555
109Antigen processing and presentation_Homo sapiens_hsa046120.33706359
110Glioma_Homo sapiens_hsa052140.33679251
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.32895729
112Circadian rhythm_Homo sapiens_hsa047100.32621802
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30935927
114Ras signaling pathway_Homo sapiens_hsa040140.30066739
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29364651
116Rap1 signaling pathway_Homo sapiens_hsa040150.26415260
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26290038
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.25626685
119Melanogenesis_Homo sapiens_hsa049160.25497223
120Acute myeloid leukemia_Homo sapiens_hsa052210.24063740
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23990445
122FoxO signaling pathway_Homo sapiens_hsa040680.23925859
123Hepatitis B_Homo sapiens_hsa051610.23425395
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.23268969
125Pancreatic cancer_Homo sapiens_hsa052120.21432419
126Selenocompound metabolism_Homo sapiens_hsa004500.20061834
127Influenza A_Homo sapiens_hsa051640.19593909
128AMPK signaling pathway_Homo sapiens_hsa041520.18480865
129Non-small cell lung cancer_Homo sapiens_hsa052230.18429273
130Shigellosis_Homo sapiens_hsa051310.15450916
131Protein digestion and absorption_Homo sapiens_hsa049740.15106079
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14977082
133Arachidonic acid metabolism_Homo sapiens_hsa005900.14525315
134Inositol phosphate metabolism_Homo sapiens_hsa005620.13689448
135MAPK signaling pathway_Homo sapiens_hsa040100.13064797
136Dilated cardiomyopathy_Homo sapiens_hsa054140.12660257

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