CTBP2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)8.28533679
2behavioral response to ethanol (GO:0048149)7.05780419
3negative regulation of cAMP-mediated signaling (GO:0043951)6.28555538
4opioid receptor signaling pathway (GO:0038003)6.21749810
5negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.02817594
6sequestering of actin monomers (GO:0042989)5.85317966
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.96949242
8positive regulation of cAMP-mediated signaling (GO:0043950)4.87567423
9regulation of protein glycosylation (GO:0060049)4.84950176
10adult feeding behavior (GO:0008343)4.83274014
11ether lipid metabolic process (GO:0046485)4.77509677
12cellular ketone body metabolic process (GO:0046950)4.56646391
13epithelial cilium movement (GO:0003351)4.51260063
14ribosomal small subunit assembly (GO:0000028)4.47799044
15regulation of female receptivity (GO:0045924)4.10865161
16regulation of acrosome reaction (GO:0060046)4.05324962
17ketone body metabolic process (GO:1902224)4.02763195
18regulation of translational termination (GO:0006449)4.00232749
19thrombin receptor signaling pathway (GO:0070493)3.98475184
20cell-cell junction maintenance (GO:0045217)3.97284660
21piRNA metabolic process (GO:0034587)3.88815171
22indolalkylamine metabolic process (GO:0006586)3.77936591
23translational termination (GO:0006415)3.63459854
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57751856
25glycerol ether metabolic process (GO:0006662)3.57118337
26viral transcription (GO:0019083)3.54815444
27negative regulation of nitric oxide biosynthetic process (GO:0045019)3.47745102
28female mating behavior (GO:0060180)3.41926006
29behavioral response to nicotine (GO:0035095)3.37445796
30cell junction maintenance (GO:0034331)3.36747876
31ether metabolic process (GO:0018904)3.34506929
32neuronal action potential (GO:0019228)3.33962776
33base-excision repair, AP site formation (GO:0006285)3.33007476
34positive regulation of amino acid transport (GO:0051957)3.32515333
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29642443
36heme transport (GO:0015886)3.27116837
37ncRNA catabolic process (GO:0034661)3.26699286
38cilium movement (GO:0003341)3.25188436
39positive regulation of organic acid transport (GO:0032892)3.23464538
40tryptophan metabolic process (GO:0006568)3.20402452
41aggressive behavior (GO:0002118)3.20292512
42positive regulation of fatty acid transport (GO:2000193)3.17198603
43tryptophan catabolic process (GO:0006569)3.16206029
44indole-containing compound catabolic process (GO:0042436)3.16206029
45indolalkylamine catabolic process (GO:0046218)3.16206029
46negative regulation of glycoprotein biosynthetic process (GO:0010561)3.15666707
47positive regulation of icosanoid secretion (GO:0032305)3.13991689
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11397875
49regulation of glutamate receptor signaling pathway (GO:1900449)3.10189382
50cellular response to ammonium ion (GO:0071242)3.08037495
51pyrimidine dimer repair (GO:0006290)3.04801130
52translational elongation (GO:0006414)3.03246408
53mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01428359
54L-fucose catabolic process (GO:0042355)2.95118538
55fucose catabolic process (GO:0019317)2.95118538
56L-fucose metabolic process (GO:0042354)2.95118538
57positive regulation of uterine smooth muscle contraction (GO:0070474)2.94566624
58preassembly of GPI anchor in ER membrane (GO:0016254)2.94274042
59maturation of SSU-rRNA (GO:0030490)2.92907849
60cotranslational protein targeting to membrane (GO:0006613)2.92906809
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92404189
62seminiferous tubule development (GO:0072520)2.89675846
63protein targeting to ER (GO:0045047)2.88859258
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84750888
65rRNA modification (GO:0000154)2.82717408
66sphingoid metabolic process (GO:0046519)2.80891105
67rRNA methylation (GO:0031167)2.80527632
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.80255090
69NADH dehydrogenase complex assembly (GO:0010257)2.80255090
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80255090
71cellular response to alkaloid (GO:0071312)2.77862869
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77561471
73protein localization to endoplasmic reticulum (GO:0070972)2.76144132
74kynurenine metabolic process (GO:0070189)2.75222836
75establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73380633
76cAMP catabolic process (GO:0006198)2.73104094
77energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69165567
78ATP synthesis coupled proton transport (GO:0015986)2.69165567
79microtubule severing (GO:0051013)2.67657363
80protein complex biogenesis (GO:0070271)2.67268147
81DNA deamination (GO:0045006)2.65267716
82ventricular system development (GO:0021591)2.64931786
83purine deoxyribonucleotide metabolic process (GO:0009151)2.64773609
84cGMP metabolic process (GO:0046068)2.63782669
85regulation of timing of cell differentiation (GO:0048505)2.63501449
86neurofilament cytoskeleton organization (GO:0060052)2.62654595
87regulation of hexokinase activity (GO:1903299)2.62070306
88regulation of glucokinase activity (GO:0033131)2.62070306
89regulation of icosanoid secretion (GO:0032303)2.61799852
90regulation of cAMP-mediated signaling (GO:0043949)2.60676585
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59789655
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59690141
93regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58465459
94cellular protein complex disassembly (GO:0043624)2.55974278
95replication fork processing (GO:0031297)2.54051739
96omega-hydroxylase P450 pathway (GO:0097267)2.52451535
97iron coordination entity transport (GO:1901678)2.49751722
98positive regulation of T-helper 1 type immune response (GO:0002827)2.49339446
99viral life cycle (GO:0019058)2.45855425
100neurotransmitter catabolic process (GO:0042135)2.45797007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.88454929
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.75714085
3EZH2_22144423_ChIP-Seq_EOC_Human3.59516032
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.49832463
5GBX2_23144817_ChIP-Seq_PC3_Human3.39046907
6ZNF274_21170338_ChIP-Seq_K562_Hela3.25716296
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14862433
8TAF15_26573619_Chip-Seq_HEK293_Human2.46632873
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36037360
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.31559976
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31559976
12IGF1R_20145208_ChIP-Seq_DFB_Human2.27117358
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25240707
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20886271
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.14826725
16FUS_26573619_Chip-Seq_HEK293_Human2.02277194
17IRF1_19129219_ChIP-ChIP_H3396_Human1.99408152
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.91900749
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91087846
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85553676
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77209486
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72497027
23P300_19829295_ChIP-Seq_ESCs_Human1.72116730
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71179521
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69278219
26RNF2_27304074_Chip-Seq_NSC_Mouse1.66611086
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66205711
28CBP_20019798_ChIP-Seq_JUKART_Human1.66205711
29REST_21632747_ChIP-Seq_MESCs_Mouse1.66034101
30BCAT_22108803_ChIP-Seq_LS180_Human1.65746414
31RXR_22108803_ChIP-Seq_LS180_Human1.65065566
32EWS_26573619_Chip-Seq_HEK293_Human1.61456957
33NANOG_19829295_ChIP-Seq_ESCs_Human1.59914413
34SOX2_19829295_ChIP-Seq_ESCs_Human1.59914413
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59519432
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.54568129
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.53824133
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51353240
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50487201
40ER_23166858_ChIP-Seq_MCF-7_Human1.48128947
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.45016401
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42174417
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40359757
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39969979
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.39601015
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39525090
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38219416
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37995268
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.37752712
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37021520
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34550522
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.34360708
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32908325
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32661629
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28150772
56TCF4_23295773_ChIP-Seq_U87_Human1.25341504
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23567838
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23357031
59TP53_22573176_ChIP-Seq_HFKS_Human1.23084602
60SMAD4_21799915_ChIP-Seq_A2780_Human1.21569774
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.19972368
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18676640
63FOXH1_21741376_ChIP-Seq_ESCs_Human1.17873925
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16690564
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.16334453
66AR_25329375_ChIP-Seq_VCAP_Human1.14614811
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14596355
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14181134
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14164676
70STAT3_23295773_ChIP-Seq_U87_Human1.11786054
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11190174
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.10254700
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10254353
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.08696552
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08643444
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.07772067
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07454004
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.07337787
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06352019
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.05294996
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05285740
82ERG_20517297_ChIP-Seq_VCAP_Human1.05173712
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04786818
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01980483
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01980483
86NANOG_20526341_ChIP-Seq_ESCs_Human1.01454324
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01086944
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99891671
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99701591
90CDX2_22108803_ChIP-Seq_LS180_Human0.98007638
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.96764514
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95316599
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95071337
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95059258
95DROSHA_22980978_ChIP-Seq_HELA_Human0.94054860
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93316307
97TCF4_22108803_ChIP-Seq_LS180_Human0.93147430
98RUNX2_22187159_ChIP-Seq_PCA_Human0.92727794
99AR_20517297_ChIP-Seq_VCAP_Human0.92528298
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.92329609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.18443021
2MP0009278_abnormal_bone_marrow4.10571755
3MP0009379_abnormal_foot_pigmentation3.84477661
4MP0003880_abnormal_central_pattern3.69868772
5MP0001968_abnormal_touch/_nociception3.44507143
6MP0002876_abnormal_thyroid_physiology3.05832001
7MP0008789_abnormal_olfactory_epithelium2.76658840
8MP0005394_taste/olfaction_phenotype2.44846091
9MP0005499_abnormal_olfactory_system2.44846091
10MP0005645_abnormal_hypothalamus_physiol2.33895226
11MP0005551_abnormal_eye_electrophysiolog2.29320354
12MP0000372_irregular_coat_pigmentation2.12889490
13MP0006292_abnormal_olfactory_placode2.10182035
14MP0000569_abnormal_digit_pigmentation2.07446557
15MP0003011_delayed_dark_adaptation2.00094038
16MP0002938_white_spotting1.89442347
17MP0005360_urolithiasis1.87911905
18MP0001905_abnormal_dopamine_level1.86757113
19MP0005646_abnormal_pituitary_gland1.84134952
20MP0001545_abnormal_hematopoietic_system1.80077670
21MP0005397_hematopoietic_system_phenotyp1.80077670
22MP0005503_abnormal_tendon_morphology1.73106363
23MP0006035_abnormal_mitochondrial_morpho1.71148645
24MP0003045_fibrosis1.62933911
25MP0006276_abnormal_autonomic_nervous1.60417970
26MP0002735_abnormal_chemical_nociception1.59830964
27MP0002822_catalepsy1.56782891
28MP0002733_abnormal_thermal_nociception1.52692063
29MP0003283_abnormal_digestive_organ1.50720267
30MP0001664_abnormal_digestion1.48324878
31MP0002638_abnormal_pupillary_reflex1.46890117
32MP0002928_abnormal_bile_duct1.46884004
33MP0003787_abnormal_imprinting1.42827517
34MP0005084_abnormal_gallbladder_morpholo1.41525546
35MP0003252_abnormal_bile_duct1.40349842
36MP0001970_abnormal_pain_threshold1.39682173
37MP0001984_abnormal_olfaction1.37940576
38MP0009745_abnormal_behavioral_response1.35725713
39MP0009764_decreased_sensitivity_to1.34804989
40MP0002272_abnormal_nervous_system1.32291136
41MP0004133_heterotaxia1.29289863
42MP0003646_muscle_fatigue1.27578759
43MP0008875_abnormal_xenobiotic_pharmacok1.26407937
44MP0001529_abnormal_vocalization1.25725902
45MP0000681_abnormal_thyroid_gland1.25566007
46MP0008872_abnormal_physiological_respon1.24367127
47MP0009046_muscle_twitch1.19914095
48MP0006072_abnormal_retinal_apoptosis1.19588570
49MP0003638_abnormal_response/metabolism_1.11928627
50MP0009780_abnormal_chondrocyte_physiolo1.11685168
51MP0001501_abnormal_sleep_pattern1.11398878
52MP0004885_abnormal_endolymph1.10538754
53MP0003186_abnormal_redox_activity1.09063393
54MP0001486_abnormal_startle_reflex1.08888234
55MP0002736_abnormal_nociception_after1.05618235
56MP0000778_abnormal_nervous_system1.04132240
57MP0005195_abnormal_posterior_eye1.04098239
58MP0003959_abnormal_lean_body1.04008071
59MP0002067_abnormal_sensory_capabilities1.01689072
60MP0001986_abnormal_taste_sensitivity1.00671400
61MP0005670_abnormal_white_adipose0.99476936
62MP0004147_increased_porphyrin_level0.98747687
63MP0000230_abnormal_systemic_arterial0.97756932
64MP0009333_abnormal_splenocyte_physiolog0.93976558
65MP0003635_abnormal_synaptic_transmissio0.93764033
66MP0000538_abnormal_urinary_bladder0.93436638
67MP0009697_abnormal_copulation0.92347513
68MP0002752_abnormal_somatic_nervous0.91760926
69MP0002572_abnormal_emotion/affect_behav0.90979834
70MP0002557_abnormal_social/conspecific_i0.90842674
71MP0003567_abnormal_fetal_cardiomyocyte0.90834143
72MP0003718_maternal_effect0.88792769
73MP0005174_abnormal_tail_pigmentation0.86713321
74MP0005253_abnormal_eye_physiology0.84532531
75MP0002734_abnormal_mechanical_nocicepti0.84448369
76MP0003633_abnormal_nervous_system0.83643789
77MP0004742_abnormal_vestibular_system0.82578070
78MP0005386_behavior/neurological_phenoty0.81125499
79MP0004924_abnormal_behavior0.81125499
80MP0003195_calcinosis0.80415733
81MP0000631_abnormal_neuroendocrine_gland0.79382166
82MP0000427_abnormal_hair_cycle0.79004969
83MP0001485_abnormal_pinna_reflex0.77709773
84MP0004142_abnormal_muscle_tone0.76577996
85MP0000462_abnormal_digestive_system0.75933203
86MP0002693_abnormal_pancreas_physiology0.75451435
87MP0000383_abnormal_hair_follicle0.75336465
88MP0008775_abnormal_heart_ventricle0.75198508
89MP0000049_abnormal_middle_ear0.72925674
90MP0000955_abnormal_spinal_cord0.71707859
91MP0000015_abnormal_ear_pigmentation0.70868904
92MP0008995_early_reproductive_senescence0.70250859
93MP0009053_abnormal_anal_canal0.69302031
94MP0002751_abnormal_autonomic_nervous0.68851002
95MP0000678_abnormal_parathyroid_gland0.67150515
96MP0001963_abnormal_hearing_physiology0.65692176
97MP0002184_abnormal_innervation0.65650730
98MP0001324_abnormal_eye_pigmentation0.64840076
99MP0002102_abnormal_ear_morphology0.64399487
100MP0002095_abnormal_skin_pigmentation0.63583656

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)7.53654189
2Type II lissencephaly (HP:0007260)4.91459189
3Volvulus (HP:0002580)4.44724510
4Intestinal atresia (HP:0011100)4.23228712
5Mesangial abnormality (HP:0001966)4.01252835
63-Methylglutaconic aciduria (HP:0003535)3.87729651
7Cerebellar dysplasia (HP:0007033)3.83342726
8Large for gestational age (HP:0001520)3.62467346
9Focal motor seizures (HP:0011153)3.56649108
10Hypochromic microcytic anemia (HP:0004840)3.52279724
11Agitation (HP:0000713)3.34073383
12Abnormality of the aortic arch (HP:0012303)3.30619485
13Pancreatic islet-cell hyperplasia (HP:0004510)3.21006722
14Gaze-evoked nystagmus (HP:0000640)3.05750514
15Gastrointestinal atresia (HP:0002589)3.02529767
16Abnormality of midbrain morphology (HP:0002418)2.97950299
17Molar tooth sign on MRI (HP:0002419)2.97950299
18Abnormal rod and cone electroretinograms (HP:0008323)2.93683182
19Pancreatic fibrosis (HP:0100732)2.87485352
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.86846212
21Constricted visual fields (HP:0001133)2.70046120
22Tubular atrophy (HP:0000092)2.68940344
23Stomach cancer (HP:0012126)2.68341532
24Absent/shortened dynein arms (HP:0200106)2.66618713
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.66618713
26Oligodontia (HP:0000677)2.66602237
27Long nose (HP:0003189)2.63651147
28Attenuation of retinal blood vessels (HP:0007843)2.63233179
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62071694
30Hypothermia (HP:0002045)2.60253276
31Abolished electroretinogram (ERG) (HP:0000550)2.57532306
32Optic nerve hypoplasia (HP:0000609)2.55699994
33Congenital ichthyosiform erythroderma (HP:0007431)2.54154113
34Anterior segment dysgenesis (HP:0007700)2.49180017
35Reduced antithrombin III activity (HP:0001976)2.44044257
36Lissencephaly (HP:0001339)2.43926913
37Abnormality of the renal medulla (HP:0100957)2.42273838
38Dysdiadochokinesis (HP:0002075)2.41509452
39Hyperthyroidism (HP:0000836)2.40881850
40Abnormal respiratory motile cilium physiology (HP:0012261)2.40847657
41Congenital stationary night blindness (HP:0007642)2.40158488
42Oligodactyly (hands) (HP:0001180)2.38145079
43Abnormality of cells of the erythroid lineage (HP:0012130)2.35167556
44Broad alveolar ridges (HP:0000187)2.33083181
45Myositis (HP:0100614)2.32379849
46Tented upper lip vermilion (HP:0010804)2.30711340
47Bony spicule pigmentary retinopathy (HP:0007737)2.29565815
48Abnormality of macular pigmentation (HP:0008002)2.28571432
49Abnormal number of erythroid precursors (HP:0012131)2.28221594
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27472634
51Retinal dysplasia (HP:0007973)2.19054073
52Abnormality of the renal cortex (HP:0011035)2.18766774
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.18645309
54Hypoplasia of the brainstem (HP:0002365)2.18645309
55Nephronophthisis (HP:0000090)2.16058813
56Abnormal respiratory motile cilium morphology (HP:0005938)2.13063168
57Abnormal respiratory epithelium morphology (HP:0012253)2.13063168
58Broad-based gait (HP:0002136)2.12767797
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12570432
60Hypoproteinemia (HP:0003075)2.11652751
61Abnormal ciliary motility (HP:0012262)2.10776279
62Stenosis of the external auditory canal (HP:0000402)2.07159189
63Focal seizures (HP:0007359)2.06076869
64Asplenia (HP:0001746)2.04649985
65Lipid accumulation in hepatocytes (HP:0006561)2.03767885
66Increased hepatocellular lipid droplets (HP:0006565)2.01742490
67Abnormality of the parietal bone (HP:0002696)2.01737719
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.99989168
69Renal Fanconi syndrome (HP:0001994)1.99569530
70Increased CSF lactate (HP:0002490)1.99404107
71Elevated erythrocyte sedimentation rate (HP:0003565)1.97653869
72Type I transferrin isoform profile (HP:0003642)1.96961475
73Parakeratosis (HP:0001036)1.95945458
74Hepatocellular necrosis (HP:0001404)1.94115308
75Medial flaring of the eyebrow (HP:0010747)1.93824614
76Poor head control (HP:0002421)1.92018358
77Pachygyria (HP:0001302)1.91753432
78Limb dystonia (HP:0002451)1.91651645
79Polydipsia (HP:0001959)1.90938742
80Abnormal drinking behavior (HP:0030082)1.90938742
81Poor speech (HP:0002465)1.88748670
82Concave nail (HP:0001598)1.88633067
83Severe combined immunodeficiency (HP:0004430)1.88081075
84Abnormality of the vitreous humor (HP:0004327)1.87819336
85Thyroiditis (HP:0100646)1.85997317
86Severe muscular hypotonia (HP:0006829)1.84414950
87Mitochondrial inheritance (HP:0001427)1.83068164
88Pancreatic cysts (HP:0001737)1.82908834
89Scotoma (HP:0000575)1.81949528
90Hepatic necrosis (HP:0002605)1.81220344
91Progressive inability to walk (HP:0002505)1.81099505
92Renal cortical cysts (HP:0000803)1.81020551
93Amelogenesis imperfecta (HP:0000705)1.79894811
94Abnormality of incisor morphology (HP:0011063)1.78362551
95Pendular nystagmus (HP:0012043)1.77222452
96Chronic otitis media (HP:0000389)1.76463875
97Increased corneal curvature (HP:0100692)1.75363535
98Keratoconus (HP:0000563)1.75363535
99Genital tract atresia (HP:0001827)1.74820084
100Ectropion (HP:0000656)1.74810245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK26.48364155
2TAF14.69169936
3FRK4.16320120
4PINK13.25770993
5BMPR1B2.89126011
6TAOK32.82896268
7NUAK12.52027792
8FLT32.27755054
9TGFBR12.21592055
10ADRBK12.07303615
11CDK191.97343096
12WNK31.88905580
13NTRK11.79632775
14DYRK21.74198267
15GRK11.70274017
16VRK21.70136828
17KIT1.55610616
18OXSR11.55519136
19FGFR21.52443209
20ACVR1B1.41890773
21MKNK11.37489273
22PNCK1.37121773
23NTRK21.36792998
24EPHA41.29042751
25ZAK1.27105515
26PIK3CG1.26754644
27PRKCE1.17784857
28ERN11.17014215
29DYRK31.13794681
30PRKCG1.11121142
31NME21.06667863
32MATK1.01416882
33CLK11.00912493
34ZAP701.00685371
35GRK61.00337527
36STK110.98790335
37GRK50.98657839
38MAP2K40.96943992
39TEC0.92407828
40PASK0.87800542
41CAMK1G0.86927890
42DYRK1A0.84405403
43ITK0.83039165
44MARK10.81884921
45MAPK130.79195529
46MAP2K30.78142503
47BTK0.75539263
48MAPKAPK50.75428452
49ERBB40.72978471
50MINK10.70472672
51TXK0.68875548
52MAP2K60.67673834
53KDR0.67455606
54PRKCH0.61947690
55CSNK1G20.61405114
56MAP2K20.61087997
57IRAK10.60576851
58PRKCQ0.59892645
59NEK20.59077106
60CAMK2A0.58560260
61PLK20.55440496
62CSNK1G30.55394011
63VRK10.55247100
64IRAK30.54810553
65LCK0.54413856
66IKBKB0.54247718
67DAPK20.53714201
68CSF1R0.50887190
69PRKG20.50807195
70SIK20.48904029
71MAP4K20.48283134
72ERBB20.47627457
73CSNK1A1L0.47211258
74SYK0.44816591
75MKNK20.44162611
76EPHB20.43840470
77TBK10.42293626
78INSRR0.41733026
79TRPM70.41060579
80CSNK2A20.40595011
81CAMK10.39466063
82ABL10.38395331
83TLK10.38305471
84CSNK1G10.36143238
85PRKACA0.33992882
86CSNK1E0.33543548
87PRKCA0.33298958
88GRK70.31493645
89LRRK20.30037179
90MAPK150.29872563
91PRKG10.29424041
92AKT10.28883524
93MAPK110.28379097
94CDK80.26136722
95MAP3K50.25093175
96TNK20.24858510
97STK390.23963468
98MAP4K10.23522849
99IGF1R0.23414322
100PRKCZ0.23271990

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.10990605
2Ribosome_Homo sapiens_hsa030103.39927050
3Parkinsons disease_Homo sapiens_hsa050123.09657872
4Butanoate metabolism_Homo sapiens_hsa006502.84567623
5Phototransduction_Homo sapiens_hsa047442.72585314
6Oxidative phosphorylation_Homo sapiens_hsa001902.58353004
7Olfactory transduction_Homo sapiens_hsa047402.43232258
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32157610
9Tryptophan metabolism_Homo sapiens_hsa003802.30616785
10ABC transporters_Homo sapiens_hsa020102.11644207
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96307165
12Steroid hormone biosynthesis_Homo sapiens_hsa001401.93755378
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.91784056
14Linoleic acid metabolism_Homo sapiens_hsa005911.87532434
15Asthma_Homo sapiens_hsa053101.78859424
16Alzheimers disease_Homo sapiens_hsa050101.78150488
17Huntingtons disease_Homo sapiens_hsa050161.77679517
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70525374
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67899577
20Caffeine metabolism_Homo sapiens_hsa002321.66295520
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65357172
22Dorso-ventral axis formation_Homo sapiens_hsa043201.59373523
23Morphine addiction_Homo sapiens_hsa050321.58765685
24RNA polymerase_Homo sapiens_hsa030201.58716082
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56087094
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56027153
27Cardiac muscle contraction_Homo sapiens_hsa042601.49203250
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46287661
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.40142229
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34533386
31Chemical carcinogenesis_Homo sapiens_hsa052041.28093346
32Taste transduction_Homo sapiens_hsa047421.26628945
33Protein export_Homo sapiens_hsa030601.24553016
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19528061
35Basal transcription factors_Homo sapiens_hsa030221.18876793
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.14723187
37Arachidonic acid metabolism_Homo sapiens_hsa005901.13839484
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10003851
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.09729392
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09554588
41Base excision repair_Homo sapiens_hsa034101.07519492
42Autoimmune thyroid disease_Homo sapiens_hsa053201.05341982
43Graft-versus-host disease_Homo sapiens_hsa053321.05126600
44Retinol metabolism_Homo sapiens_hsa008301.02083779
45Purine metabolism_Homo sapiens_hsa002301.01492552
46Allograft rejection_Homo sapiens_hsa053300.98500922
47Glycerolipid metabolism_Homo sapiens_hsa005610.94940030
48Serotonergic synapse_Homo sapiens_hsa047260.89833909
49Ovarian steroidogenesis_Homo sapiens_hsa049130.89141613
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87456706
51Circadian entrainment_Homo sapiens_hsa047130.84232039
52Salivary secretion_Homo sapiens_hsa049700.83613155
53Fatty acid degradation_Homo sapiens_hsa000710.81510237
54RNA degradation_Homo sapiens_hsa030180.81135812
55Nicotine addiction_Homo sapiens_hsa050330.80118466
56Ether lipid metabolism_Homo sapiens_hsa005650.78873808
57Type I diabetes mellitus_Homo sapiens_hsa049400.76257507
58Peroxisome_Homo sapiens_hsa041460.76237900
59Fanconi anemia pathway_Homo sapiens_hsa034600.71423980
60Sulfur relay system_Homo sapiens_hsa041220.69502710
61Calcium signaling pathway_Homo sapiens_hsa040200.65541433
62beta-Alanine metabolism_Homo sapiens_hsa004100.63965717
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60728985
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58629263
65Glutamatergic synapse_Homo sapiens_hsa047240.58476301
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56814728
67Basal cell carcinoma_Homo sapiens_hsa052170.56537017
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55691359
69Renin secretion_Homo sapiens_hsa049240.55207336
70Homologous recombination_Homo sapiens_hsa034400.54234001
71Metabolic pathways_Homo sapiens_hsa011000.53508484
72Starch and sucrose metabolism_Homo sapiens_hsa005000.52936142
73Hedgehog signaling pathway_Homo sapiens_hsa043400.51156065
74Propanoate metabolism_Homo sapiens_hsa006400.50257652
75Proteasome_Homo sapiens_hsa030500.50243395
76Axon guidance_Homo sapiens_hsa043600.47735697
77Sphingolipid metabolism_Homo sapiens_hsa006000.45485342
78Long-term depression_Homo sapiens_hsa047300.42438784
79Rheumatoid arthritis_Homo sapiens_hsa053230.41020181
80Primary immunodeficiency_Homo sapiens_hsa053400.40922201
81Notch signaling pathway_Homo sapiens_hsa043300.39150414
82GABAergic synapse_Homo sapiens_hsa047270.37561636
83Pancreatic secretion_Homo sapiens_hsa049720.36790680
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34807012
85Oxytocin signaling pathway_Homo sapiens_hsa049210.33189973
86Nitrogen metabolism_Homo sapiens_hsa009100.31517017
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.31436262
88Fatty acid elongation_Homo sapiens_hsa000620.31189334
89Histidine metabolism_Homo sapiens_hsa003400.30816282
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29950612
91Regulation of autophagy_Homo sapiens_hsa041400.29227439
92Glutathione metabolism_Homo sapiens_hsa004800.28769404
93Insulin secretion_Homo sapiens_hsa049110.28421063
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27586051
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27400908
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27184506
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.26897730
98Staphylococcus aureus infection_Homo sapiens_hsa051500.26324114
99Systemic lupus erythematosus_Homo sapiens_hsa053220.24035036
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22915208

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