CTBP2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)6.48557765
2aggressive behavior (GO:0002118)5.44316093
3negative regulation of thymocyte apoptotic process (GO:0070244)4.91165402
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.89220809
5purine nucleotide salvage (GO:0032261)4.41614611
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.37138367
7positive regulation of B cell differentiation (GO:0045579)4.19460743
8regulation of T-helper 1 cell differentiation (GO:0045625)4.17565746
9B cell differentiation (GO:0030183)3.87296078
10hepatocyte differentiation (GO:0070365)3.81707403
11sleep (GO:0030431)3.78035890
12interkinetic nuclear migration (GO:0022027)3.77461376
13mature B cell differentiation involved in immune response (GO:0002313)3.77299316
14negative regulation of B cell apoptotic process (GO:0002903)3.73812053
15regulation of B cell apoptotic process (GO:0002902)3.73128022
16seminiferous tubule development (GO:0072520)3.66669684
17purine-containing compound salvage (GO:0043101)3.61301020
18positive regulation of prostaglandin secretion (GO:0032308)3.61213335
19antigen processing and presentation of endogenous antigen (GO:0019883)3.58245391
20mature B cell differentiation (GO:0002335)3.57665609
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56303170
22forebrain morphogenesis (GO:0048853)3.52601218
23maternal behavior (GO:0042711)3.52279878
24positive regulation of T-helper cell differentiation (GO:0045624)3.51429244
25positive regulation of interleukin-17 production (GO:0032740)3.49872202
26regulation of female receptivity (GO:0045924)3.49321635
27base-excision repair, AP site formation (GO:0006285)3.46676969
28parental behavior (GO:0060746)3.46294092
29pyrimidine nucleotide catabolic process (GO:0006244)3.43316338
30negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.31971171
31positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.30655383
32positive regulation of megakaryocyte differentiation (GO:0045654)3.29878064
33deoxyribonucleotide catabolic process (GO:0009264)3.28012097
34ribosomal small subunit assembly (GO:0000028)3.27328888
35regulation of penile erection (GO:0060405)3.27002430
36deoxyribose phosphate catabolic process (GO:0046386)3.22870397
37immunoglobulin mediated immune response (GO:0016064)3.22137328
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21150529
39negative regulation of T cell apoptotic process (GO:0070233)3.19545518
40regulation of thymocyte apoptotic process (GO:0070243)3.18991625
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.18419130
42regulation of B cell receptor signaling pathway (GO:0050855)3.17756583
43regulation of B cell differentiation (GO:0045577)3.16799059
44positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.14208821
45T cell differentiation in thymus (GO:0033077)3.13239459
46endothelium development (GO:0003158)3.12981583
47negative regulation of lymphocyte apoptotic process (GO:0070229)3.07429433
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03141689
49heme transport (GO:0015886)3.01851943
50opioid receptor signaling pathway (GO:0038003)2.98846420
51regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.97936020
52B cell activation (GO:0042113)2.97421064
53B cell receptor signaling pathway (GO:0050853)2.96242945
54negative regulation of transcription by competitive promoter binding (GO:0010944)2.95910516
55female mating behavior (GO:0060180)2.95206631
56positive regulation of granulocyte differentiation (GO:0030854)2.94852840
57poly(A)+ mRNA export from nucleus (GO:0016973)2.94633604
58Peyers patch development (GO:0048541)2.94081974
59mucosal-associated lymphoid tissue development (GO:0048537)2.94081974
60positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93389841
61V(D)J recombination (GO:0033151)2.92735604
62positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91085045
63regulation of antigen processing and presentation (GO:0002577)2.90281094
64positive regulation of antigen processing and presentation (GO:0002579)2.89469325
65GMP metabolic process (GO:0046037)2.86139998
66pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85183880
67actin nucleation (GO:0045010)2.84817914
68regulation of prostaglandin secretion (GO:0032306)2.84783599
69hematopoietic stem cell proliferation (GO:0071425)2.83772497
70response to peptidoglycan (GO:0032494)2.83381554
71cholesterol catabolic process (GO:0006707)2.83034188
72sterol catabolic process (GO:0016127)2.83034188
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80021473
74regulation of icosanoid secretion (GO:0032303)2.79268024
75positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.73589818
76branched-chain amino acid catabolic process (GO:0009083)2.73225103
77short-chain fatty acid metabolic process (GO:0046459)2.73087391
78negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71875610
79purine deoxyribonucleotide catabolic process (GO:0009155)2.69818186
80translational termination (GO:0006415)2.68414529
81valine metabolic process (GO:0006573)2.68241208
82megakaryocyte development (GO:0035855)2.67050937
83positive regulation of digestive system process (GO:0060456)2.65033232
84branched-chain amino acid metabolic process (GO:0009081)2.64271333
85hyperosmotic salinity response (GO:0042538)2.63103474
86B cell mediated immunity (GO:0019724)2.60951429
87mitochondrial DNA replication (GO:0006264)2.60937562
88blood vessel maturation (GO:0001955)2.60860408
89positive regulation of icosanoid secretion (GO:0032305)2.60797575
902-deoxyribonucleotide metabolic process (GO:0009394)2.59295701
91positive regulation of T-helper 1 type immune response (GO:0002827)2.59238721
92viral transcription (GO:0019083)2.59158418
93grooming behavior (GO:0007625)2.58505082
94detection of bacterium (GO:0016045)2.58184125
95monoamine transport (GO:0015844)2.56378005
96mast cell activation involved in immune response (GO:0002279)2.55753609
97mast cell degranulation (GO:0043303)2.55753609
98xenobiotic catabolic process (GO:0042178)2.53995100
99regulation of T-helper cell differentiation (GO:0045622)2.51022268
100response to hydroperoxide (GO:0033194)2.50538948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.13904945
2SCL_19346495_ChIP-Seq_HPC-7_Human4.31863240
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.94458916
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.15381515
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.00360774
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99328398
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88911021
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.73543273
9ZNF274_21170338_ChIP-Seq_K562_Hela2.53626118
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.44086687
11MYB_26560356_Chip-Seq_TH2_Human2.35529994
12RUNX_20019798_ChIP-Seq_JUKART_Human2.32340204
13FOXP3_21729870_ChIP-Seq_TREG_Human2.32076104
14IGF1R_20145208_ChIP-Seq_DFB_Human2.31084255
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.29953435
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28676550
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25097975
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21765582
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98959181
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91816771
21GATA3_27048872_Chip-Seq_THYMUS_Human1.90693504
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84254250
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83037636
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82989355
25VDR_23849224_ChIP-Seq_CD4+_Human1.79583952
26SPI1_23547873_ChIP-Seq_NB4_Human1.78016828
27GATA2_22383799_ChIP-Seq_G1ME_Mouse1.76438755
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.73847764
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71004766
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70854919
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.67465066
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66690257
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63628317
34TP53_22573176_ChIP-Seq_HFKS_Human1.60617698
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.59645780
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53414035
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.48646260
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47583178
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.46727520
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46650969
41ELK1_19687146_ChIP-ChIP_HELA_Human1.46488944
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.45207293
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41003552
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40960165
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.40581908
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38416426
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36692017
48MYC_18940864_ChIP-ChIP_HL60_Human1.34887372
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32880790
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30726314
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30453641
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27559883
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.27098780
54EWS_26573619_Chip-Seq_HEK293_Human1.25615143
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25049048
56VDR_24763502_ChIP-Seq_THP-1_Human1.24174777
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23838238
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22876745
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22628534
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22559248
61MYC_22102868_ChIP-Seq_BL_Human1.21383853
62MYB_26560356_Chip-Seq_TH1_Human1.20861545
63GATA3_26560356_Chip-Seq_TH2_Human1.19438390
64GATA1_22025678_ChIP-Seq_K562_Human1.18107901
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17104754
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12919151
67GATA3_26560356_Chip-Seq_TH1_Human1.12015671
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11488765
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11158825
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10053181
71UTX_26944678_Chip-Seq_JUKART_Human1.09984990
72P300_27268052_Chip-Seq_Bcells_Human1.09649422
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08529994
74VDR_22108803_ChIP-Seq_LS180_Human1.08095369
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07199688
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.06581005
77FUS_26573619_Chip-Seq_HEK293_Human1.04041777
78CIITA_25753668_ChIP-Seq_RAJI_Human1.03510331
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.02954941
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02471855
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.02263956
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02263956
83ER_23166858_ChIP-Seq_MCF-7_Human1.01860487
84AR_20517297_ChIP-Seq_VCAP_Human0.99104115
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98866107
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98777434
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98038320
88IRF1_19129219_ChIP-ChIP_H3396_Human0.97348682
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97050012
90ERG_20517297_ChIP-Seq_VCAP_Human0.95502873
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95408508
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94661054
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94632672
94SMRT_27268052_Chip-Seq_Bcells_Human0.94218679
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91799822
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91512432
97P53_21459846_ChIP-Seq_SAOS-2_Human0.89044780
98ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88383913
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87868039
100BCL6_27268052_Chip-Seq_Bcells_Human0.87660061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.48665424
2MP0001545_abnormal_hematopoietic_system3.58916227
3MP0005397_hematopoietic_system_phenotyp3.58916227
4MP0001835_abnormal_antigen_presentation3.48897585
5MP0005084_abnormal_gallbladder_morpholo3.36160658
6MP0000465_gastrointestinal_hemorrhage3.04151594
7MP0002132_abnormal_respiratory_system2.84800051
8MP0009697_abnormal_copulation2.46270441
9MP0005464_abnormal_platelet_physiology2.38045160
10MP0002876_abnormal_thyroid_physiology2.23299306
11MP0006292_abnormal_olfactory_placode2.21137343
12MP0002396_abnormal_hematopoietic_system2.13844611
13MP0003303_peritoneal_inflammation2.08233125
14MP0004808_abnormal_hematopoietic_stem2.06132103
15MP0000372_irregular_coat_pigmentation2.04727283
16MP0003806_abnormal_nucleotide_metabolis2.01446910
17MP0002166_altered_tumor_susceptibility1.98308425
18MP0005646_abnormal_pituitary_gland1.92748861
19MP0002148_abnormal_hypersensitivity_rea1.90547367
20MP0002102_abnormal_ear_morphology1.88017427
21MP0001800_abnormal_humoral_immune1.86707931
22MP0005075_abnormal_melanosome_morpholog1.85076122
23MP0005000_abnormal_immune_tolerance1.80656398
24MP0008875_abnormal_xenobiotic_pharmacok1.78115323
25MP0008058_abnormal_DNA_repair1.76009927
26MP0008057_abnormal_DNA_replication1.75919641
27MP0003763_abnormal_thymus_physiology1.73238152
28MP0009785_altered_susceptibility_to1.65595068
29MP0002006_tumorigenesis1.64642778
30MP0002398_abnormal_bone_marrow1.62622747
31MP0006276_abnormal_autonomic_nervous1.61261042
32MP0005671_abnormal_response_to1.58587960
33MP0005670_abnormal_white_adipose1.57826372
34MP0003045_fibrosis1.55706780
35MP0000689_abnormal_spleen_morphology1.48719621
36MP0003718_maternal_effect1.46499716
37MP0008872_abnormal_physiological_respon1.43187245
38MP0002452_abnormal_antigen_presenting1.43110525
39MP0000462_abnormal_digestive_system1.41226328
40MP0005645_abnormal_hypothalamus_physiol1.40804042
41MP0000685_abnormal_immune_system1.39370084
42MP0002420_abnormal_adaptive_immunity1.38406119
43MP0002723_abnormal_immune_serum1.38319174
44MP0001819_abnormal_immune_cell1.37997180
45MP0000013_abnormal_adipose_tissue1.35638423
46MP0001905_abnormal_dopamine_level1.34200014
47MP0005387_immune_system_phenotype1.33304421
48MP0001790_abnormal_immune_system1.33304421
49MP0002138_abnormal_hepatobiliary_system1.30109592
50MP0002735_abnormal_chemical_nociception1.29226664
51MP0003724_increased_susceptibility_to1.27154439
52MP0010094_abnormal_chromosome_stability1.26750946
53MP0001968_abnormal_touch/_nociception1.25873494
54MP0002722_abnormal_immune_system1.25538703
55MP0000716_abnormal_immune_system1.25156946
56MP0005025_abnormal_response_to1.23018179
57MP0002928_abnormal_bile_duct1.22591679
58MP0004947_skin_inflammation1.20475685
59MP0003943_abnormal_hepatobiliary_system1.18917043
60MP0004147_increased_porphyrin_level1.18710085
61MP0010155_abnormal_intestine_physiology1.17388188
62MP0002095_abnormal_skin_pigmentation1.15164475
63MP0002419_abnormal_innate_immunity1.11935978
64MP0002019_abnormal_tumor_incidence1.10151521
65MP0001764_abnormal_homeostasis1.07095067
66MP0002429_abnormal_blood_cell1.06174380
67MP0002139_abnormal_hepatobiliary_system1.05617402
68MP0001664_abnormal_digestion1.03933361
69MP0000681_abnormal_thyroid_gland1.02019046
70MP0002405_respiratory_system_inflammati1.00949315
71MP0002822_catalepsy0.97785638
72MP0000703_abnormal_thymus_morphology0.97284348
73MP0001984_abnormal_olfaction0.93833867
74MP0003252_abnormal_bile_duct0.93518445
75MP0009333_abnormal_splenocyte_physiolog0.91849525
76MP0003787_abnormal_imprinting0.91561548
77MP0001663_abnormal_digestive_system0.91102166
78MP0005410_abnormal_fertilization0.88049888
79MP0001873_stomach_inflammation0.85741493
80MP0001879_abnormal_lymphatic_vessel0.79749399
81MP0008469_abnormal_protein_level0.78756015
82MP0006036_abnormal_mitochondrial_physio0.77441431
83MP0010386_abnormal_urinary_bladder0.77404005
84MP0000516_abnormal_urinary_system0.76130912
85MP0005367_renal/urinary_system_phenotyp0.76130912
86MP0008775_abnormal_heart_ventricle0.75318076
87MP0003183_abnormal_peptide_metabolism0.75054654
88MP0005379_endocrine/exocrine_gland_phen0.74906623
89MP0000230_abnormal_systemic_arterial0.74864975
90MP0000383_abnormal_hair_follicle0.74139764
91MP0001845_abnormal_inflammatory_respons0.73293775
92MP0003436_decreased_susceptibility_to0.70807313
93MP0009379_abnormal_foot_pigmentation0.70518045
94MP0001881_abnormal_mammary_gland0.70374129
95MP0003866_abnormal_defecation0.69436450
96MP0003186_abnormal_redox_activity0.67005879
97MP0005381_digestive/alimentary_phenotyp0.66695331
98MP0005220_abnormal_exocrine_pancreas0.66415068
99MP0005360_urolithiasis0.65367474
100MP0001529_abnormal_vocalization0.64405070

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)8.29714638
2Abnormality of B cell number (HP:0010975)7.66431503
3Panhypogammaglobulinemia (HP:0003139)7.19941931
4Severe combined immunodeficiency (HP:0004430)6.94228275
5Hypoplasia of the thymus (HP:0000778)6.48769235
6Thyroiditis (HP:0100646)6.22634447
7Hypoproteinemia (HP:0003075)5.79828314
8Combined immunodeficiency (HP:0005387)5.55851381
9Agammaglobulinemia (HP:0004432)4.99610630
10Reduced antithrombin III activity (HP:0001976)4.33714741
11Acute lymphatic leukemia (HP:0006721)4.18636758
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.94560908
13Hypochromic microcytic anemia (HP:0004840)3.86106262
14Aplasia/Hypoplasia of the thymus (HP:0010515)3.75277179
15Eosinophilia (HP:0001880)3.72827896
16Papilledema (HP:0001085)3.66447749
17T lymphocytopenia (HP:0005403)3.61690399
18Granulocytopenia (HP:0001913)3.56843520
19Recurrent fungal infections (HP:0002841)3.42713751
20Recurrent viral infections (HP:0004429)3.41507058
21Meningitis (HP:0001287)3.41477118
22IgG deficiency (HP:0004315)3.31327071
23Erythroderma (HP:0001019)3.25156579
24Abnormality of eosinophils (HP:0001879)3.22060294
25Elevated erythrocyte sedimentation rate (HP:0003565)3.18402647
26Abnormality of T cell number (HP:0011839)3.16188609
27Stomatitis (HP:0010280)3.12056522
28Leukocytosis (HP:0001974)3.10426720
29Abnormal rod and cone electroretinograms (HP:0008323)3.03355059
30Type I transferrin isoform profile (HP:0003642)2.95877365
31Abnormal protein glycosylation (HP:0012346)2.83491869
32Abnormal glycosylation (HP:0012345)2.83491869
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.83491869
34Abnormal protein N-linked glycosylation (HP:0012347)2.83491869
35Abnormality of the thymus (HP:0000777)2.73567379
36Abnormality of T cells (HP:0002843)2.65874364
37Methylmalonic acidemia (HP:0002912)2.65713340
38Attenuation of retinal blood vessels (HP:0007843)2.56732635
39Methylmalonic aciduria (HP:0012120)2.56177038
40Cellulitis (HP:0100658)2.51658417
41Aplastic anemia (HP:0001915)2.50998537
42Microcytic anemia (HP:0001935)2.50359886
43Stomach cancer (HP:0012126)2.49485904
44Colon cancer (HP:0003003)2.49351491
45Sepsis (HP:0100806)2.44270251
46Dicarboxylic aciduria (HP:0003215)2.41061749
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41061749
48Myositis (HP:0100614)2.29897265
49Thoracic kyphosis (HP:0002942)2.27794083
50Limb hypertonia (HP:0002509)2.27123180
51Constricted visual fields (HP:0001133)2.24863252
52Obstructive lung disease (HP:0006536)2.24196030
53Chronic obstructive pulmonary disease (HP:0006510)2.24196030
54Decreased central vision (HP:0007663)2.22491329
55Abnormality of the prostate (HP:0008775)2.16261224
56Hyperthyroidism (HP:0000836)2.00513077
57Dysdiadochokinesis (HP:0002075)1.96290456
58Increased intramyocellular lipid droplets (HP:0012240)1.96131577
59Increased muscle lipid content (HP:0009058)1.91750805
60Verrucae (HP:0200043)1.91290154
61Papilloma (HP:0012740)1.91290154
62Renal Fanconi syndrome (HP:0001994)1.90872195
63Poikiloderma (HP:0001029)1.90185730
64Mesangial abnormality (HP:0001966)1.89694506
65Rhabdomyolysis (HP:0003201)1.88174338
66Microvesicular hepatic steatosis (HP:0001414)1.87608371
67Chronic sinusitis (HP:0011109)1.87007507
68Abnormality of macular pigmentation (HP:0008002)1.85731826
69Prolonged bleeding time (HP:0003010)1.84805605
70Lipid accumulation in hepatocytes (HP:0006561)1.83782449
71Abnormality of midbrain morphology (HP:0002418)1.81394270
72Molar tooth sign on MRI (HP:0002419)1.81394270
73Entropion (HP:0000621)1.80895122
74Hypochromic anemia (HP:0001931)1.80126210
75Recurrent bronchitis (HP:0002837)1.79124474
76Increased hepatocellular lipid droplets (HP:0006565)1.74276010
77Skin rash (HP:0000988)1.70484172
78Abnormality of DNA repair (HP:0003254)1.68775023
79Ketosis (HP:0001946)1.67717664
80Erythema (HP:0010783)1.66263815
81Thrombocytosis (HP:0001894)1.66245992
82Dehydration (HP:0001944)1.66037759
83Autoimmune hemolytic anemia (HP:0001890)1.63398280
84Encephalitis (HP:0002383)1.62858535
85Urticaria (HP:0001025)1.62271479
86Rectal fistula (HP:0100590)1.62168483
87Rectovaginal fistula (HP:0000143)1.62168483
88Mitochondrial inheritance (HP:0001427)1.57490578
89Thyroid-stimulating hormone excess (HP:0002925)1.56568776
90IgM deficiency (HP:0002850)1.55056816
91Abnormality of vitamin B metabolism (HP:0004340)1.53030555
92Asplenia (HP:0001746)1.52145514
93Amyotrophic lateral sclerosis (HP:0007354)1.51936900
94Increased IgM level (HP:0003496)1.51669046
95Chronic otitis media (HP:0000389)1.50794210
96Abnormality of the heme biosynthetic pathway (HP:0010472)1.49821470
97Intention tremor (HP:0002080)1.49032317
98Acute hepatic failure (HP:0006554)1.48404724
99Epistaxis (HP:0000421)1.47183345
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.46955538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK15.33122993
2TAOK33.63707632
3BCKDK3.17071882
4SCYL23.13824926
5FLT33.09369014
6KIT2.92004215
7MAP4K22.88260016
8CDK192.79333725
9MATK2.76491810
10TAF12.54012638
11VRK22.40148336
12MAP2K32.21382299
13FES2.11625010
14EIF2AK32.11373308
15NME22.02255154
16TXK1.91992263
17PIK3CG1.88069799
18LATS11.87986762
19MAP4K11.79363353
20KDR1.53971723
21ERN11.45340297
22FRK1.44640183
23SYK1.44204898
24GRK61.39062461
25PINK11.35346953
26CSF1R1.34385269
27TBK11.34215450
28TEC1.32172525
29TNK21.26122305
30JAK31.24254806
31PRKG21.21565092
32ITK1.09869873
33BTK1.09126550
34BMPR1B1.06740746
35ADRBK21.05714088
36ZAP701.01729537
37CLK10.99517743
38LCK0.97948450
39PRKCQ0.95665267
40GRK50.92536363
41PIM20.92464674
42ZAK0.89911469
43MAP2K20.88716481
44LYN0.88635380
45BMPR20.88397428
46PBK0.88113358
47OXSR10.86114763
48IKBKB0.82175019
49WNK30.82110448
50MAP3K70.75267117
51DAPK20.74628315
52TGFBR10.72988383
53MAP2K60.72642014
54EIF2AK20.71122735
55NEK20.70620613
56MAP3K60.70046011
57HCK0.66303977
58MAP3K140.65232688
59TAOK20.61620113
60GRK10.61521730
61IKBKE0.58357530
62PLK40.58125248
63MAP3K50.56225040
64MAP3K130.53039557
65RPS6KA60.52168906
66VRK10.52143515
67RPS6KC10.51779655
68RPS6KL10.51779655
69MET0.49900660
70DAPK10.49417373
71ADRBK10.47117491
72CCNB10.45938956
73MKNK10.44819216
74STK110.44291197
75TRPM70.43935354
76RPS6KA50.43909838
77DYRK1A0.43297700
78MAPK70.41677037
79PTK2B0.41170674
80CDK70.40326787
81CDK80.40160416
82NTRK10.39528574
83CDK30.37726561
84FYN0.35749373
85PIK3CA0.34877673
86NLK0.34749750
87IGF1R0.34411557
88MAPK40.33859774
89RPS6KB20.33035465
90MAP3K110.30187207
91PRKCD0.29034146
92RAF10.28218830
93DAPK30.26874337
94TGFBR20.25804346
95MAPK30.24505548
96BUB10.23402593
97PRKCA0.22813265
98PIM10.21316263
99ATR0.20515506
100MAP3K10.20467788

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.02489081
2Primary immunodeficiency_Homo sapiens_hsa053403.72354316
3Asthma_Homo sapiens_hsa053103.29160596
4Allograft rejection_Homo sapiens_hsa053302.86235085
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.83681842
6Autoimmune thyroid disease_Homo sapiens_hsa053202.69368072
7Base excision repair_Homo sapiens_hsa034102.47830780
8Type I diabetes mellitus_Homo sapiens_hsa049402.46424956
9Graft-versus-host disease_Homo sapiens_hsa053322.40383036
10Ribosome_Homo sapiens_hsa030102.30016592
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03949677
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96633869
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85567072
14RNA polymerase_Homo sapiens_hsa030201.78840271
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73495173
16Leishmaniasis_Homo sapiens_hsa051401.71893807
17Hematopoietic cell lineage_Homo sapiens_hsa046401.60823001
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54428956
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49289647
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47104572
21Antigen processing and presentation_Homo sapiens_hsa046121.46108338
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40759829
23Caffeine metabolism_Homo sapiens_hsa002321.40422150
24Arachidonic acid metabolism_Homo sapiens_hsa005901.32191031
25Phototransduction_Homo sapiens_hsa047441.31111122
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.30859857
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29926873
28Peroxisome_Homo sapiens_hsa041461.29494601
29Glutathione metabolism_Homo sapiens_hsa004801.29418187
30Linoleic acid metabolism_Homo sapiens_hsa005911.29226522
31Platelet activation_Homo sapiens_hsa046111.24173289
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20192891
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19843256
34Fanconi anemia pathway_Homo sapiens_hsa034601.19297171
35Pyrimidine metabolism_Homo sapiens_hsa002401.17974265
36Homologous recombination_Homo sapiens_hsa034401.16897959
37Propanoate metabolism_Homo sapiens_hsa006401.16608482
38Sulfur relay system_Homo sapiens_hsa041221.14955535
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14758546
40Purine metabolism_Homo sapiens_hsa002301.13550029
41Butanoate metabolism_Homo sapiens_hsa006501.12021363
42Herpes simplex infection_Homo sapiens_hsa051681.10947410
43Rheumatoid arthritis_Homo sapiens_hsa053231.06993749
44Chemical carcinogenesis_Homo sapiens_hsa052041.06104248
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00436644
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.97474160
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96291625
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95369594
49Nucleotide excision repair_Homo sapiens_hsa034200.91507248
50Tryptophan metabolism_Homo sapiens_hsa003800.91108750
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.90184318
52Salivary secretion_Homo sapiens_hsa049700.87718261
53Staphylococcus aureus infection_Homo sapiens_hsa051500.85191243
54Viral myocarditis_Homo sapiens_hsa054160.82575140
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80680488
56Proteasome_Homo sapiens_hsa030500.77976213
57B cell receptor signaling pathway_Homo sapiens_hsa046620.77725933
58Tuberculosis_Homo sapiens_hsa051520.75038173
59Parkinsons disease_Homo sapiens_hsa050120.74926994
60Olfactory transduction_Homo sapiens_hsa047400.73498742
61Fatty acid elongation_Homo sapiens_hsa000620.72749590
62Ether lipid metabolism_Homo sapiens_hsa005650.69202853
63DNA replication_Homo sapiens_hsa030300.68464422
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68092692
65Taste transduction_Homo sapiens_hsa047420.66297456
66Renin secretion_Homo sapiens_hsa049240.63464512
67Systemic lupus erythematosus_Homo sapiens_hsa053220.63271727
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62830177
69Regulation of autophagy_Homo sapiens_hsa041400.62745432
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62671722
71Mismatch repair_Homo sapiens_hsa034300.62560319
72ABC transporters_Homo sapiens_hsa020100.62216505
73Oxidative phosphorylation_Homo sapiens_hsa001900.61952428
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.59384848
75African trypanosomiasis_Homo sapiens_hsa051430.58289811
76Basal transcription factors_Homo sapiens_hsa030220.57521527
77Retinol metabolism_Homo sapiens_hsa008300.55562239
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.55273489
79RNA transport_Homo sapiens_hsa030130.55053707
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50878609
81Lysosome_Homo sapiens_hsa041420.49267661
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48646164
83Epstein-Barr virus infection_Homo sapiens_hsa051690.44763624
84Toxoplasmosis_Homo sapiens_hsa051450.44145799
85Measles_Homo sapiens_hsa051620.42920312
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.42079711
87Metabolic pathways_Homo sapiens_hsa011000.41549538
88Long-term depression_Homo sapiens_hsa047300.41067018
89Selenocompound metabolism_Homo sapiens_hsa004500.39035313
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.38274529
91RNA degradation_Homo sapiens_hsa030180.37403711
92Influenza A_Homo sapiens_hsa051640.35346631
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35082089
94N-Glycan biosynthesis_Homo sapiens_hsa005100.33016015
95Pyruvate metabolism_Homo sapiens_hsa006200.32707573
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.31554011
97Serotonergic synapse_Homo sapiens_hsa047260.31139204
98Pancreatic secretion_Homo sapiens_hsa049720.29063315
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27908864
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27835657

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