ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mesenchymal-epithelial cell signaling (GO:0060638)	9.14916534
2	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	5.92676954
3	monoubiquitinated protein deubiquitination (GO:0035520)	5.08048139
4	bone trabecula formation (GO:0060346)	4.80703733
5	regulation of male gonad development (GO:2000018)	4.68278105
6	otic vesicle formation (GO:0030916)	4.62464136
7	positive regulation of male gonad development (GO:2000020)	4.39017464
8	branching involved in salivary gland morphogenesis (GO:0060445)	4.38330514
9	regulation of phospholipase A2 activity (GO:0032429)	4.27230403
10	mesenchymal cell proliferation (GO:0010463)	3.99192056
11	lateral sprouting from an epithelium (GO:0060601)	3.94797872
12	positive regulation of receptor internalization (GO:0002092)	3.86670677
13	protein localization to cell surface (GO:0034394)	3.84761744
14	GMP metabolic process (GO:0046037)	3.63269452
15	negative regulation of complement activation (GO:0045916)	3.61768065
16	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.57009902
17	mesonephros development (GO:0001823)	3.49607735
18	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.49172538
19	kidney mesenchyme development (GO:0072074)	3.48224519
20	metanephric mesenchyme development (GO:0072075)	3.46107926
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.45147878
22	positive regulation of osteoblast proliferation (GO:0033690)	3.41426589
23	positive regulation of epidermal cell differentiation (GO:0045606)	3.33455599
24	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.33173459
25	trivalent inorganic anion homeostasis (GO:0072506)	3.29720682
26	phosphate ion homeostasis (GO:0055062)	3.29720682
27	pericardium development (GO:0060039)	3.24738833
28	branch elongation of an epithelium (GO:0060602)	3.20840720
29	auditory behavior (GO:0031223)	3.12045164
30	keratan sulfate catabolic process (GO:0042340)	3.10756032
31	collagen fibril organization (GO:0030199)	3.10676965
32	negative regulation of protein activation cascade (GO:2000258)	3.07083421
33	peptidyl-proline hydroxylation (GO:0019511)	3.03687321
34	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.99530502
35	lung secretory cell differentiation (GO:0061140)	2.99267313
36	glomerular visceral epithelial cell development (GO:0072015)	2.98422270
37	regulation of cholesterol esterification (GO:0010872)	2.98108599
38	limb bud formation (GO:0060174)	2.97515782
39	regulation of cell proliferation involved in kidney development (GO:1901722)	2.97114016
40	primary amino compound metabolic process (GO:1901160)	2.96889846
41	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.95371499
42	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.93912328
43	axon extension involved in axon guidance (GO:0048846)	2.93912328
44	organ induction (GO:0001759)	2.93529312
45	regulation of fatty acid beta-oxidation (GO:0031998)	2.91198672
46	glomerular basement membrane development (GO:0032836)	2.89903054
47	protein prenylation (GO:0018342)	2.89682043
48	prenylation (GO:0097354)	2.89682043
49	dorsal/ventral axis specification (GO:0009950)	2.87515663
50	tooth mineralization (GO:0034505)	2.85832567
51	cell differentiation involved in metanephros development (GO:0072202)	2.85065661
52	chondrocyte development (GO:0002063)	2.83025119
53	white fat cell differentiation (GO:0050872)	2.78369651
54	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.78205619
55	vasculature development (GO:0001944)	2.72539348
56	serotonin metabolic process (GO:0042428)	2.71869761
57	nucleotide salvage (GO:0043173)	2.71717560
58	somite rostral/caudal axis specification (GO:0032525)	2.71195741
59	kidney morphogenesis (GO:0060993)	2.70652901
60	glomerular epithelial cell development (GO:0072310)	2.69619839
61	smooth muscle tissue development (GO:0048745)	2.66897802
62	phasic smooth muscle contraction (GO:0014821)	2.65307311
63	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.63860285
64	face morphogenesis (GO:0060325)	2.62942358
65	nucleoside salvage (GO:0043174)	2.62624581
66	ureteric bud development (GO:0001657)	2.62499836
67	toxin metabolic process (GO:0009404)	2.62176632
68	non-canonical Wnt signaling pathway (GO:0035567)	2.60663076
69	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.60425043
70	UMP metabolic process (GO:0046049)	2.60425043
71	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.60425043
72	UMP biosynthetic process (GO:0006222)	2.60425043
73	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.59574496
74	platelet-derived growth factor receptor signaling pathway (GO:0048008)	2.58942056
75	serotonin receptor signaling pathway (GO:0007210)	2.57831954
76	axis elongation (GO:0003401)	2.56899000
77	muscle cell fate commitment (GO:0042693)	2.55948491
78	regulation of hippo signaling (GO:0035330)	2.55675281
79	regulation of receptor internalization (GO:0002090)	2.55245058
80	decidualization (GO:0046697)	2.54998721
81	cranial suture morphogenesis (GO:0060363)	2.54789525
82	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.54765641
83	regulation of translation, ncRNA-mediated (GO:0045974)	2.54765641
84	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.54765641
85	mesonephric epithelium development (GO:0072163)	2.54219350
86	mesonephric tubule development (GO:0072164)	2.53333789
87	histone deubiquitination (GO:0016578)	2.53168779
88	bone remodeling (GO:0046849)	2.52315994
89	regulation of odontogenesis (GO:0042481)	2.50503316
90	adrenal gland development (GO:0030325)	2.50092736
91	negative regulation of humoral immune response (GO:0002921)	2.48457072
92	nodal signaling pathway (GO:0038092)	2.45625857
93	positive regulation of gastrulation (GO:2000543)	2.45493309
94	regulation of organ formation (GO:0003156)	2.45266792
95	protein hydroxylation (GO:0018126)	2.44779907
96	paraxial mesoderm development (GO:0048339)	2.44415340
97	response to hepatocyte growth factor (GO:0035728)	2.44199424
98	cellular response to hepatocyte growth factor stimulus (GO:0035729)	2.44199424
99	embryonic digestive tract morphogenesis (GO:0048557)	2.42549609
100	establishment of planar polarity (GO:0001736)	2.42233485

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.36758476
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	4.22734255
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.52365306
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.02347391
5	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.00489521
6	VDR_22108803_ChIP-Seq_LS180_Human	2.88307224
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.69702535
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57202272
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.41251764
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.35199630
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.24789657
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.22169491
13	TP53_16413492_ChIP-PET_HCT116_Human	2.18482428
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.13150802
15	P300_19829295_ChIP-Seq_ESCs_Human	2.09992643
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.06702944
17	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	2.03629452
18	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.94171906
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.91735329
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91735329
21	TP53_18474530_ChIP-ChIP_U2OS_Human	1.90172165
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85247353
23	CJUN_26792858_Chip-Seq_BT549_Human	1.84780858
24	FUS_26573619_Chip-Seq_HEK293_Human	1.84406787
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83654020
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.83621902
27	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.78591543
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72584200
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69568518
30	STAT3_23295773_ChIP-Seq_U87_Human	1.68386938
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64355971
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62592633
33	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.62487581
34	EWS_26573619_Chip-Seq_HEK293_Human	1.61922646
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58550654
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56995249
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56975927
38	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56725498
39	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.54276025
40	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.53597250
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52749051
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49515910
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45987614
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42783247
45	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.41979424
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38686188
47	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.37806758
48	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.37806758
49	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.35274742
50	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.31482430
51	KDM2B_26808549_Chip-Seq_REH_Human	1.30722443
52	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.30459673
53	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.30097442
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.29584418
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29365723
56	TCF4_23295773_ChIP-Seq_U87_Human	1.27928981
57	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.27920397
58	AHR_22903824_ChIP-Seq_MCF-7_Human	1.27383518
59	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.26438287
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25213115
61	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.24937241
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24215870
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24060256
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.23315180
65	BRD4_25478319_ChIP-Seq_HGPS_Human	1.23226232
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.22599875
67	AR_25329375_ChIP-Seq_VCAP_Human	1.21285531
68	ZNF274_21170338_ChIP-Seq_K562_Hela	1.16608763
69	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.15973497
70	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13300568
71	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13077428
72	TBL1_22424771_ChIP-Seq_293T_Human	1.12783513
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11718370
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.10542550
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09874340
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09488773
77	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.09269692
78	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.09093366
79	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09071416
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08344194
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07227851
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.06906375
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06906375
84	JUN_21703547_ChIP-Seq_K562_Human	1.06205785
85	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05431901
86	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05005748
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04167545
88	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.03156166
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02007692
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01765687
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01060610
92	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97866444
93	AR_19668381_ChIP-Seq_PC3_Human	0.97099141
94	TP63_23658742_ChIP-Seq_EP156T_Human	0.95177929
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.94391224
96	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.93734536
97	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.93675850
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91680791
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88142820
100	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.87857328

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005503_abnormal_tendon_morphology	4.85684688
2	MP0005171_absent_coat_pigmentation	3.88240804
3	MP0010030_abnormal_orbit_morphology	3.72731358
4	MP0002102_abnormal_ear_morphology	3.57586262
5	MP0005275_abnormal_skin_tensile	3.54727525
6	MP0003136_yellow_coat_color	3.00193875
7	MP0009250_abnormal_appendicular_skeleto	2.63606559
8	MP0005248_abnormal_Harderian_gland	2.62598653
9	MP0003942_abnormal_urinary_system	2.30489279
10	MP0005508_abnormal_skeleton_morphology	2.20027373
11	MP0006072_abnormal_retinal_apoptosis	2.19437078
12	MP0000566_synostosis	2.12528530
13	MP0008438_abnormal_cutaneous_collagen	2.02415913
14	MP0001542_abnormal_bone_strength	1.96268151
15	MP0002282_abnormal_trachea_morphology	1.89074674
16	MP0002638_abnormal_pupillary_reflex	1.88616821
17	MP0002837_dystrophic_cardiac_calcinosis	1.82316399
18	MP0006054_spinal_hemorrhage	1.81675280
19	MP0003646_muscle_fatigue	1.77692113
20	MP0005257_abnormal_intraocular_pressure	1.72389197
21	MP0002938_white_spotting	1.69145984
22	MP0005253_abnormal_eye_physiology	1.67656286
23	MP0000049_abnormal_middle_ear	1.65834396
24	MP0006292_abnormal_olfactory_placode	1.58288638
25	MP0005595_abnormal_vascular_smooth	1.56950345
26	MP0000383_abnormal_hair_follicle	1.55834926
27	MP0003279_aneurysm	1.52744002
28	MP0003935_abnormal_craniofacial_develop	1.49049232
29	MP0002277_abnormal_respiratory_mucosa	1.48109136
30	MP0003937_abnormal_limbs/digits/tail_de	1.47499148
31	MP0003283_abnormal_digestive_organ	1.44609943
32	MP0008775_abnormal_heart_ventricle	1.44486237
33	MP0002108_abnormal_muscle_morphology	1.41805399
34	MP0003122_maternal_imprinting	1.41475075
35	MP0002295_abnormal_pulmonary_circulatio	1.40417140
36	MP0009697_abnormal_copulation	1.37731809
37	MP0000013_abnormal_adipose_tissue	1.37439335
38	MP0000537_abnormal_urethra_morphology	1.34582548
39	MP0001727_abnormal_embryo_implantation	1.34280035
40	MP0005076_abnormal_cell_differentiation	1.28167117
41	MP0004883_abnormal_blood_vessel	1.27804835
42	MP0001243_abnormal_dermal_layer	1.26297419
43	MP0002168_other_aberrant_phenotype	1.25337479
44	MP0001968_abnormal_touch/_nociception	1.23373164
45	MP0000428_abnormal_craniofacial_morphol	1.22451927
46	MP0003890_abnormal_embryonic-extraembry	1.21264951
47	MP0002928_abnormal_bile_duct	1.20763536
48	MP0000432_abnormal_head_morphology	1.19509460
49	MP0001286_abnormal_eye_development	1.18909306
50	MP0002233_abnormal_nose_morphology	1.15791807
51	MP0003878_abnormal_ear_physiology	1.14840142
52	MP0005377_hearing/vestibular/ear_phenot	1.14840142
53	MP0005023_abnormal_wound_healing	1.14190208
54	MP0003786_premature_aging	1.13606050
55	MP0010368_abnormal_lymphatic_system	1.12646134
56	MP0002697_abnormal_eye_size	1.10146569
57	MP0003938_abnormal_ear_development	1.06575097
58	MP0004272_abnormal_basement_membrane	1.05680354
59	MP0000163_abnormal_cartilage_morphology	1.05101702
60	MP0003011_delayed_dark_adaptation	1.02511807
61	MP0002653_abnormal_ependyma_morphology	1.02457427
62	MP0003755_abnormal_palate_morphology	1.02372882
63	MP0000762_abnormal_tongue_morphology	1.00918188
64	MP0003121_genomic_imprinting	1.00135472
65	MP0002115_abnormal_skeleton_extremities	0.99946156
66	MP0003119_abnormal_digestive_system	0.99294310
67	MP0000427_abnormal_hair_cycle	0.97020370
68	MP0002736_abnormal_nociception_after	0.96193009
69	MP0002932_abnormal_joint_morphology	0.95605902
70	MP0000681_abnormal_thyroid_gland	0.94842737
71	MP0000462_abnormal_digestive_system	0.94511286
72	MP0010678_abnormal_skin_adnexa	0.94194635
73	MP0005174_abnormal_tail_pigmentation	0.93759967
74	MP0002109_abnormal_limb_morphology	0.92859455
75	MP0001324_abnormal_eye_pigmentation	0.91285280
76	MP0003943_abnormal_hepatobiliary_system	0.88846393
77	MP0005391_vision/eye_phenotype	0.85321262
78	MP0000534_abnormal_ureter_morphology	0.82887235
79	MP0005164_abnormal_response_to	0.81358190
80	MP0004133_heterotaxia	0.80980760
81	MP0003091_abnormal_cell_migration	0.80619140
82	MP0002132_abnormal_respiratory_system	0.80420941
83	MP0002249_abnormal_larynx_morphology	0.80357965
84	MP0003123_paternal_imprinting	0.79117071
85	MP0001485_abnormal_pinna_reflex	0.77305875
86	MP0001958_emphysema	0.76711874
87	MP0000631_abnormal_neuroendocrine_gland	0.75719344
88	MP0001299_abnormal_eye_distance/	0.75315190
89	MP0000613_abnormal_salivary_gland	0.75105634
90	MP0003115_abnormal_respiratory_system	0.75067754
91	MP0000003_abnormal_adipose_tissue	0.73199539
92	MP0000358_abnormal_cell_content/	0.71357902
93	MP0001879_abnormal_lymphatic_vessel	0.70845647
94	MP0000230_abnormal_systemic_arterial	0.70511643
95	MP0002116_abnormal_craniofacial_bone	0.70424827
96	MP0000778_abnormal_nervous_system	0.69248435
97	MP0002114_abnormal_axial_skeleton	0.68005957
98	MP0005390_skeleton_phenotype	0.67417816
99	MP0001270_distended_abdomen	0.62507661
100	MP0002735_abnormal_chemical_nociception	0.61541166

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent frontal sinuses (HP:0002688)	6.05724896
2	Subacute progressive viral hepatitis (HP:0006572)	4.84861610
3	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	4.55207212
4	Aplasia involving bones of the upper limbs (HP:0009823)	3.95565831
5	Aplasia of the phalanges of the hand (HP:0009802)	3.95565831
6	Aplasia involving bones of the extremities (HP:0009825)	3.95565831
7	Abnormality of the frontal sinuses (HP:0002687)	3.79624228
8	Cutaneous melanoma (HP:0012056)	3.78284645
9	Metaphyseal dysplasia (HP:0100255)	3.65376461
10	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.62955801
11	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.45626099
12	Partial duplication of the phalanx of hand (HP:0009999)	3.37722267
13	Partial duplication of thumb phalanx (HP:0009944)	3.37594162
14	Hyperglycinemia (HP:0002154)	3.37034801
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.35395891
16	Short tibia (HP:0005736)	3.30976562
17	Broad metatarsal (HP:0001783)	3.27740302
18	Pigmentary retinal degeneration (HP:0001146)	3.11227515
19	Preaxial foot polydactyly (HP:0001841)	2.93741199
20	Choroideremia (HP:0001139)	2.90185936
21	Spondylolisthesis (HP:0003302)	2.85456164
22	Abnormality of incisor morphology (HP:0011063)	2.85235418
23	Fibular hypoplasia (HP:0003038)	2.78607932
24	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.75546709
25	Mild short stature (HP:0003502)	2.68804829
26	Micronodular cirrhosis (HP:0001413)	2.67553161
27	True hermaphroditism (HP:0010459)	2.66837370
28	Potter facies (HP:0002009)	2.65715129
29	Facial shape deformation (HP:0011334)	2.65715129
30	Ulnar bowing (HP:0003031)	2.61236936
31	Bell-shaped thorax (HP:0001591)	2.60557520
32	Abnormality of the ischium (HP:0003174)	2.60191650
33	Premature rupture of membranes (HP:0001788)	2.58755653
34	Methylmalonic aciduria (HP:0012120)	2.47842162
35	Short hallux (HP:0010109)	2.43956363
36	Increased corneal curvature (HP:0100692)	2.37517524
37	Keratoconus (HP:0000563)	2.37517524
38	Large for gestational age (HP:0001520)	2.35129845
39	Methylmalonic acidemia (HP:0002912)	2.32488789
40	Viral hepatitis (HP:0006562)	2.31592524
41	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.29616693
42	Abnormality of the 2nd finger (HP:0004100)	2.28068869
43	Duplication of thumb phalanx (HP:0009942)	2.27402608
44	Delayed closure of the anterior fontanelle (HP:0001476)	2.26449431
45	Congenital, generalized hypertrichosis (HP:0004540)	2.25965835
46	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.23742572
47	Osteolytic defects of the hand bones (HP:0009699)	2.23742572
48	Widely patent fontanelles and sutures (HP:0004492)	2.22917216
49	Wide anterior fontanel (HP:0000260)	2.20894838
50	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.20033203
51	Narrow palate (HP:0000189)	2.15144160
52	Decreased lacrimation (HP:0000633)	2.13372463
53	Cerebellar dysplasia (HP:0007033)	2.12402286
54	Hypoplastic ischia (HP:0003175)	2.11615274
55	Abnormal sex determination (HP:0012244)	2.11408028
56	Sex reversal (HP:0012245)	2.11408028
57	Arthropathy (HP:0003040)	2.09279699
58	Short middle phalanx of finger (HP:0005819)	2.08917130
59	Persistence of primary teeth (HP:0006335)	2.08047514
60	Decreased skull ossification (HP:0004331)	2.07150309
61	Abnormality of the parietal bone (HP:0002696)	2.02759589
62	Peritonitis (HP:0002586)	2.01908176
63	Delayed cranial suture closure (HP:0000270)	2.01292811
64	Spinal cord lesions (HP:0100561)	1.99276655
65	Syringomyelia (HP:0003396)	1.99276655
66	Irregular vertebral endplates (HP:0003301)	1.97301051
67	Abnormality of skull ossification (HP:0002703)	1.96579157
68	Vitreoretinal degeneration (HP:0000655)	1.95986229
69	Asymmetry of the thorax (HP:0001555)	1.95790189
70	Transitional cell carcinoma of the bladder (HP:0006740)	1.93406473
71	Femoral bowing (HP:0002980)	1.91952094
72	Coronal craniosynostosis (HP:0004440)	1.90870227
73	Bladder neoplasm (HP:0009725)	1.90724095
74	Bladder carcinoma (HP:0002862)	1.90724095
75	Meningioma (HP:0002858)	1.89569692
76	Missing ribs (HP:0000921)	1.88714706
77	Radial bowing (HP:0002986)	1.86140503
78	Bifid tongue (HP:0010297)	1.85144497
79	Wormian bones (HP:0002645)	1.84264953
80	Patent foramen ovale (HP:0001655)	1.83245093
81	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.83170238
82	Septo-optic dysplasia (HP:0100842)	1.82743849
83	Hepatocellular carcinoma (HP:0001402)	1.82017450
84	Megalencephaly (HP:0001355)	1.81215949
85	Type II lissencephaly (HP:0007260)	1.80365375
86	Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)	1.77544718
87	Limited hip movement (HP:0008800)	1.76486816
88	Alacrima (HP:0000522)	1.76199303
89	Hyperinsulinemic hypoglycemia (HP:0000825)	1.75866689
90	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.75396272
91	Abnormality of the middle phalanges of the hand (HP:0009833)	1.73847738
92	Metaphyseal cupping (HP:0003021)	1.71811254
93	Nephronophthisis (HP:0000090)	1.71286139
94	Abnormality of midbrain morphology (HP:0002418)	1.69625740
95	Molar tooth sign on MRI (HP:0002419)	1.69625740
96	Bowed forearm bones (HP:0003956)	1.69079388
97	Bowing of the arm (HP:0006488)	1.69079388
98	Short nail (HP:0001799)	1.68644168
99	Hypoplastic pelvis (HP:0008839)	1.65274641
100	Rhinitis (HP:0012384)	1.65059975

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.87460873
2	FGFR2	3.71418272
3	BMPR1B	3.47695613
4	ACVR1B	3.08663769
5	CASK	2.82712794
6	MKNK2	2.38458197
7	NLK	2.28631071
8	TNIK	2.24072435
9	WEE1	1.92779605
10	NEK9	1.76786235
11	BRSK2	1.70999530
12	MAP2K4	1.62054765
13	CSNK1G1	1.60663581
14	TYRO3	1.58305905
15	MAP3K6	1.57865336
16	STK38L	1.57529765
17	TIE1	1.53997921
18	INSRR	1.48435315
19	IRAK1	1.43549430
20	TGFBR1	1.42544689
21	MAP3K7	1.38288385
22	PDK2	1.37102508
23	WNK3	1.36839649
24	AKT3	1.34240685
25	CAMK1G	1.30473540
26	PIM2	1.26808141
27	ERBB2	1.23061841
28	GSK3A	1.21528539
29	STK39	1.18458209
30	EPHA2	1.18024277
31	PIK3CG	1.16621175
32	NME1	1.15206002
33	OXSR1	1.11711720
34	MKNK1	1.11238235
35	RAF1	1.08423193
36	PDGFRB	1.08120548
37	PRKAA2	1.06764898
38	PTK2B	1.05499489
39	MAP3K4	1.04221876
40	MAP3K13	1.03710955
41	STK3	1.01619695
42	SGK2	1.01248290
43	CSNK1G3	0.98493219
44	MAP2K7	0.97474154
45	ZAK	0.96372970
46	PRKCE	0.94895403
47	NUAK1	0.92347899
48	TLK1	0.90910802
49	PLK4	0.90449283
50	ADRBK1	0.89759535
51	PLK2	0.85572758
52	FGFR1	0.83566293
53	DMPK	0.82853770
54	MAP3K11	0.81010230
55	PNCK	0.78525279
56	CSNK1G2	0.78236905
57	EPHB1	0.78054570
58	SGK3	0.76303833
59	PAK2	0.75884178
60	EPHB2	0.74989333
61	STK38	0.74730923
62	SGK223	0.73541195
63	SGK494	0.73541195
64	CAMK1D	0.73426943
65	PLK3	0.72541349
66	MELK	0.67756473
67	MARK2	0.67736065
68	STK11	0.67359247
69	CSNK1A1L	0.63470389
70	IRAK2	0.61573165
71	VRK1	0.60464562
72	TRPM7	0.57736981
73	NTRK1	0.56922011
74	MAPK7	0.53395844
75	WNK4	0.51896121
76	STK4	0.50442080
77	ROCK1	0.49941096
78	CAMK1	0.49923851
79	NEK6	0.48636148
80	CHUK	0.47752973
81	PLK1	0.47699353
82	MTOR	0.47699172
83	BRD4	0.46409040
84	MAPK15	0.45686485
85	FER	0.43867932
86	PTK2	0.43333134
87	SGK1	0.42876844
88	ADRBK2	0.41362659
89	DYRK1A	0.39375700
90	PTK6	0.39067002
91	CAMK4	0.38534247
92	CAMK2D	0.37103129
93	MST4	0.36285949
94	DAPK2	0.34812943
95	PAK3	0.34721669
96	FGFR3	0.31811923
97	ATM	0.31347629
98	LRRK2	0.29870259
99	DYRK3	0.29598281
100	PDGFRA	0.28830076

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	3.35772852
2	Basal cell carcinoma_Homo sapiens_hsa05217	2.84035052
3	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.29508967
4	ECM-receptor interaction_Homo sapiens_hsa04512	2.08572291
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.04709512
6	Hippo signaling pathway_Homo sapiens_hsa04390	2.00696808
7	Melanoma_Homo sapiens_hsa05218	1.97888094
8	Type II diabetes mellitus_Homo sapiens_hsa04930	1.95900475
9	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.95805090
10	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.91628000
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72725557
12	Homologous recombination_Homo sapiens_hsa03440	1.70124059
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61425297
14	ABC transporters_Homo sapiens_hsa02010	1.53493495
15	Wnt signaling pathway_Homo sapiens_hsa04310	1.49136291
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46785590
17	Taste transduction_Homo sapiens_hsa04742	1.46168959
18	Sulfur metabolism_Homo sapiens_hsa00920	1.44413622
19	Renin-angiotensin system_Homo sapiens_hsa04614	1.41688006
20	Propanoate metabolism_Homo sapiens_hsa00640	1.39654886
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.29999419
22	Folate biosynthesis_Homo sapiens_hsa00790	1.26989149
23	Proteoglycans in cancer_Homo sapiens_hsa05205	1.25097583
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21390450
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.21331788
26	Serotonergic synapse_Homo sapiens_hsa04726	1.21067965
27	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.17986944
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.17395095
29	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.15883132
30	Melanogenesis_Homo sapiens_hsa04916	1.13020429
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11675478
32	FoxO signaling pathway_Homo sapiens_hsa04068	1.11296170
33	Butanoate metabolism_Homo sapiens_hsa00650	1.08639268
34	Focal adhesion_Homo sapiens_hsa04510	1.07727961
35	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.06793320
36	Pathways in cancer_Homo sapiens_hsa05200	1.06504892
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06435545
38	Lysine degradation_Homo sapiens_hsa00310	1.05569347
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04015978
40	p53 signaling pathway_Homo sapiens_hsa04115	1.00340968
41	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.00210487
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00200535
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97987402
44	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.97063612
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96932671
46	Adherens junction_Homo sapiens_hsa04520	0.96921364
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92504800
48	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.88446269
49	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.85456943
50	Prostate cancer_Homo sapiens_hsa05215	0.83532433
51	Rap1 signaling pathway_Homo sapiens_hsa04015	0.81817668
52	MicroRNAs in cancer_Homo sapiens_hsa05206	0.81644448
53	Endometrial cancer_Homo sapiens_hsa05213	0.79285057
54	Insulin secretion_Homo sapiens_hsa04911	0.78880955
55	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.77241863
56	AMPK signaling pathway_Homo sapiens_hsa04152	0.77179011
57	Axon guidance_Homo sapiens_hsa04360	0.72975141
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.69716421
59	Insulin resistance_Homo sapiens_hsa04931	0.69270341
60	RNA polymerase_Homo sapiens_hsa03020	0.69160209
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68353158
62	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.68020272
63	Peroxisome_Homo sapiens_hsa04146	0.67003003
64	Ras signaling pathway_Homo sapiens_hsa04014	0.65702183
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63788070
66	Small cell lung cancer_Homo sapiens_hsa05222	0.62769439
67	Gap junction_Homo sapiens_hsa04540	0.59815306
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58186838
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58129339
70	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.58085502
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.57897367
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56058238
73	Circadian rhythm_Homo sapiens_hsa04710	0.55891202
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55693661
75	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.55493646
76	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53385215
77	Malaria_Homo sapiens_hsa05144	0.53229896
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52784458
79	Mismatch repair_Homo sapiens_hsa03430	0.52095852
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.52086068
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.50688141
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.49864820
83	Renin secretion_Homo sapiens_hsa04924	0.48309949
84	Colorectal cancer_Homo sapiens_hsa05210	0.47694594
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46187595
86	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.45697126
87	Regulation of autophagy_Homo sapiens_hsa04140	0.45472703
88	Cholinergic synapse_Homo sapiens_hsa04725	0.45311453
89	Huntingtons disease_Homo sapiens_hsa05016	0.44212558
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43495465
91	Olfactory transduction_Homo sapiens_hsa04740	0.43049899
92	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.42278297
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41846622
94	RNA degradation_Homo sapiens_hsa03018	0.41801358
95	Sulfur relay system_Homo sapiens_hsa04122	0.41605851
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39838119
97	Mineral absorption_Homo sapiens_hsa04978	0.38313322
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36809800
99	Tight junction_Homo sapiens_hsa04530	0.36633231
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.34198422

CTBP2P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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