CTBS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08193858
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.08193858
3modulation by symbiont of host immune response (GO:0052553)5.08193858
4positive regulation by symbiont of host defense response (GO:0052509)5.08193858
5modulation by symbiont of host defense response (GO:0052031)5.08193858
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08193858
7positive regulation of gamma-delta T cell activation (GO:0046645)4.71692095
8negative regulation of cell killing (GO:0031342)4.57085378
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57085378
10response to peptidoglycan (GO:0032494)4.42854697
11urate metabolic process (GO:0046415)4.29005420
12regulation of interferon-beta biosynthetic process (GO:0045357)4.21444730
13detection of other organism (GO:0098543)4.19963776
14detection of external biotic stimulus (GO:0098581)4.14321775
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.08933406
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07764895
17cysteine metabolic process (GO:0006534)4.05119093
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04035407
19negative regulation of interleukin-12 production (GO:0032695)4.00171589
20L-phenylalanine catabolic process (GO:0006559)4.00145324
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.00145324
22cellular extravasation (GO:0045123)3.92255326
23antigen processing and presentation of endogenous antigen (GO:0019883)3.91742298
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90023368
25L-phenylalanine metabolic process (GO:0006558)3.82477915
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82477915
27positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.78256227
28detection of bacterium (GO:0016045)3.74160498
29drug transmembrane transport (GO:0006855)3.73367416
30neutrophil activation (GO:0042119)3.72687860
31aromatic amino acid family catabolic process (GO:0009074)3.72240141
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70572913
33positive regulation of interferon-alpha production (GO:0032727)3.69876390
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.68418607
35glyoxylate metabolic process (GO:0046487)3.68370091
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58934264
37response to host immune response (GO:0052572)3.58934264
38detection of biotic stimulus (GO:0009595)3.55943517
39microglial cell activation (GO:0001774)3.55790764
40positive regulation of cellular amide metabolic process (GO:0034250)3.54247956
41homocysteine metabolic process (GO:0050667)3.51792638
42tryptophan metabolic process (GO:0006568)3.50405502
43granulocyte activation (GO:0036230)3.49728432
44indole-containing compound catabolic process (GO:0042436)3.48835761
45indolalkylamine catabolic process (GO:0046218)3.48835761
46tryptophan catabolic process (GO:0006569)3.48835761
47sulfur amino acid catabolic process (GO:0000098)3.47925102
48drug transport (GO:0015893)3.46139599
49regulation of interferon-alpha production (GO:0032647)3.45728529
50neutrophil mediated immunity (GO:0002446)3.43565379
51macrophage activation involved in immune response (GO:0002281)3.38139555
52regulation of gamma-delta T cell activation (GO:0046643)3.37748255
53bile acid biosynthetic process (GO:0006699)3.34837326
54response to host (GO:0075136)3.33736199
55response to host defenses (GO:0052200)3.33736199
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.33736199
57neutrophil activation involved in immune response (GO:0002283)3.31971663
58myeloid cell activation involved in immune response (GO:0002275)3.31770307
59protein carboxylation (GO:0018214)3.29573638
60peptidyl-glutamic acid carboxylation (GO:0017187)3.29573638
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27950792
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25117866
63aminoglycoside antibiotic metabolic process (GO:0030647)3.24635599
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.22839565
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20038649
66complement activation, alternative pathway (GO:0006957)3.19700400
67aldehyde catabolic process (GO:0046185)3.17577386
68negative regulation of T-helper cell differentiation (GO:0045623)3.17378433
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17378433
70alpha-linolenic acid metabolic process (GO:0036109)3.16759350
71production of molecular mediator involved in inflammatory response (GO:0002532)3.15318261
72hydrogen peroxide biosynthetic process (GO:0050665)3.11703167
73cellular response to type I interferon (GO:0071357)3.10571892
74type I interferon signaling pathway (GO:0060337)3.10571892
75lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10407672
76lysine metabolic process (GO:0006553)3.10374026
77lysine catabolic process (GO:0006554)3.10374026
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07872177
79response to type I interferon (GO:0034340)3.06545305
80regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.04372687
81serine family amino acid catabolic process (GO:0009071)3.03349396
82regulation of B cell receptor signaling pathway (GO:0050855)3.02498881
83regulation of mast cell degranulation (GO:0043304)2.98694442
84cellular modified amino acid catabolic process (GO:0042219)2.97742659
85respiratory burst (GO:0045730)2.95994027
86leukocyte aggregation (GO:0070486)2.93839093
87response to interleukin-15 (GO:0070672)2.93587247
88negative regulation of T cell mediated immunity (GO:0002710)2.93266893
89reverse cholesterol transport (GO:0043691)2.92257485
90urea metabolic process (GO:0019627)2.92122822
91urea cycle (GO:0000050)2.92122822
92I-kappaB phosphorylation (GO:0007252)2.91790519
93regulation of gamma-delta T cell differentiation (GO:0045586)2.89764649
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89594316
95positive regulation of mast cell activation (GO:0033005)2.88788589
96regulation of protein activation cascade (GO:2000257)2.87701357
97myeloid leukocyte mediated immunity (GO:0002444)2.86329032
98reactive oxygen species biosynthetic process (GO:1903409)2.85731003
99regulation of mast cell activation involved in immune response (GO:0033006)2.82326266
100antigen processing and presentation via MHC class Ib (GO:0002475)2.81502044
101negative regulation of leukocyte mediated immunity (GO:0002704)2.79867640
102cellular biogenic amine catabolic process (GO:0042402)2.79188939
103amine catabolic process (GO:0009310)2.79188939
104cellular response to interleukin-15 (GO:0071350)2.79153611
105leukocyte degranulation (GO:0043299)2.78992391
106regulation of mast cell activation (GO:0033003)2.78243063
107kynurenine metabolic process (GO:0070189)2.77695378
108negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77639888
109positive regulation of chemokine biosynthetic process (GO:0045080)2.76836527
110detection of molecule of bacterial origin (GO:0032490)2.75901282
111plasma lipoprotein particle clearance (GO:0034381)2.75865996
112interferon-gamma-mediated signaling pathway (GO:0060333)2.75616082
113amino-acid betaine metabolic process (GO:0006577)2.75153850
114regulation of complement activation (GO:0030449)2.74890994
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74525835
116negative regulation of interleukin-6 production (GO:0032715)2.73471053
117indolalkylamine metabolic process (GO:0006586)2.73373218
118regulation of regulatory T cell differentiation (GO:0045589)2.72598244
119cellular response to exogenous dsRNA (GO:0071360)2.70952128
120lipid oxidation (GO:0034440)2.70682938
121high-density lipoprotein particle remodeling (GO:0034375)2.70564683
122phospholipid homeostasis (GO:0055091)2.70403558
123bile acid metabolic process (GO:0008206)2.70304299
124fatty acid beta-oxidation (GO:0006635)2.69834838
125defense response to protozoan (GO:0042832)2.69104255
126negative regulation of interleukin-17 production (GO:0032700)2.68015408
127fatty acid oxidation (GO:0019395)2.67027944
128germinal center formation (GO:0002467)2.66916756
129short-chain fatty acid metabolic process (GO:0046459)2.66907554
130regulation of interleukin-8 biosynthetic process (GO:0045414)2.66727109
131superoxide anion generation (GO:0042554)2.65699821
132regulation of T-helper 2 cell differentiation (GO:0045628)2.65588720
133leukocyte migration involved in inflammatory response (GO:0002523)2.65412907
134negative regulation of complement activation (GO:0045916)2.65075700
135low-density lipoprotein particle remodeling (GO:0034374)2.63877418
136protein-lipid complex remodeling (GO:0034368)2.63202146
137macromolecular complex remodeling (GO:0034367)2.63202146
138plasma lipoprotein particle remodeling (GO:0034369)2.63202146
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63178057
140aromatic amino acid family metabolic process (GO:0009072)2.62951000
141macrophage activation (GO:0042116)2.62409223
142valine metabolic process (GO:0006573)2.62333181
143myeloid leukocyte activation (GO:0002274)2.61748458
144negative regulation of glycoprotein metabolic process (GO:1903019)2.61727364
145NAD biosynthetic process (GO:0009435)2.61415248
146regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60701094
147positive regulation of interferon-beta production (GO:0032728)2.59613252
148uronic acid metabolic process (GO:0006063)2.59413802
149glucuronate metabolic process (GO:0019585)2.59413802
150B cell receptor signaling pathway (GO:0050853)2.58926918
151T-helper 1 type immune response (GO:0042088)2.58620119
152regulation of leukocyte degranulation (GO:0043300)2.58198059
153B cell mediated immunity (GO:0019724)2.58093215
154negative regulation of humoral immune response (GO:0002921)2.57669461
155cellular glucuronidation (GO:0052695)2.57453078
156dendritic cell migration (GO:0036336)2.56794348
157response to muramyl dipeptide (GO:0032495)2.56249924
158regulation of tolerance induction (GO:0002643)2.55531872
159nitrogen cycle metabolic process (GO:0071941)2.55486030
160apoptotic cell clearance (GO:0043277)2.54772781
161fructose metabolic process (GO:0006000)2.54378500
162negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53461526
163immunoglobulin mediated immune response (GO:0016064)2.53447827
164drug catabolic process (GO:0042737)2.53120299
165toxin transport (GO:1901998)2.51989611
166basic amino acid transport (GO:0015802)2.51940517
167regulation of interleukin-6 biosynthetic process (GO:0045408)2.51307501
168regulation of T cell mediated cytotoxicity (GO:0001914)2.49626166
169positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46182097
170tolerance induction (GO:0002507)2.44123058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.07248274
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.55890166
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.31139684
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06770716
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.06005428
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.57327352
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.54036898
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.06131679
9GATA1_22025678_ChIP-Seq_K562_Human3.03511760
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.00127662
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.99193907
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82581737
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.81712558
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64503759
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60429771
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.57810941
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55544398
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43299715
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40160212
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30466995
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28064154
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.25851477
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21366568
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18261218
25SPI1_23127762_ChIP-Seq_K562_Human2.11509588
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09500864
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04826339
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94920255
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94638561
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76660711
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75756546
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71920316
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62056650
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59939299
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59483419
36VDR_24763502_ChIP-Seq_THP-1_Human1.58732205
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56235324
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55306181
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55000540
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48979145
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47762318
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47762318
43SCL_19346495_ChIP-Seq_HPC-7_Human1.47415736
44PU_27001747_Chip-Seq_BMDM_Mouse1.43897461
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.42677244
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42047533
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41953039
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41722541
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40817053
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39930431
51CLOCK_20551151_ChIP-Seq_293T_Human1.34327097
52* MAF_26560356_Chip-Seq_TH1_Human1.34305551
53* SPI1_23547873_ChIP-Seq_NB4_Human1.33417585
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33224554
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31580926
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.31429678
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26586654
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.26469517
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24936207
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24933879
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24006730
62VDR_24787735_ChIP-Seq_THP-1_Human1.23737595
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22512444
64RUNX_20019798_ChIP-Seq_JUKART_Human1.18423400
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18155450
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18115523
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.17200452
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17046914
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.14797758
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12885212
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12338487
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10962973
73* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10824752
74TFEB_21752829_ChIP-Seq_HELA_Human1.09826195
75* SOX2_20726797_ChIP-Seq_SW620_Human1.08424138
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08137567
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06895313
78GATA2_19941826_ChIP-Seq_K562_Human1.06337142
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05049573
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04306701
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02911869
82UTX_26944678_Chip-Seq_JUKART_Human1.02820434
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01675119
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.01437849
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.97154253
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97008762
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95026497
88* MYB_26560356_Chip-Seq_TH2_Human0.94419687
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92901256
90GATA1_19941826_ChIP-Seq_K562_Human0.92808277
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92586109
92GATA3_26560356_Chip-Seq_TH2_Human0.92382494
93* CJUN_26792858_Chip-Seq_BT549_Human0.91882414
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91823493
95* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91551831
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90973606
97* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90053775
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88912142
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88877836
100* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87309696
101FOXA2_19822575_ChIP-Seq_HepG2_Human0.87101446
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87050175
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.86888048
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86193773
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85866680
106TP53_16413492_ChIP-PET_HCT116_Human0.85552490
107* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84592374
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84498428
109GATA4_25053715_ChIP-Seq_YYC3_Human0.83617001
110* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82472890
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82215867
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82097710
113SMRT_27268052_Chip-Seq_Bcells_Human0.82020287
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.81316157
115AR_21909140_ChIP-Seq_LNCAP_Human0.81242699
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.80575088
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80297866
118* MYB_26560356_Chip-Seq_TH1_Human0.79797558
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79204965
120* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79114128
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78719346
122HNF4A_19822575_ChIP-Seq_HepG2_Human0.78643575
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.77245171
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76724564
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76208462
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76102763
127GATA3_27048872_Chip-Seq_THYMUS_Human0.75963613
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75591666
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75136816
130IRF1_19129219_ChIP-ChIP_H3396_Human0.74626750
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73754674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.05700551
2MP0002139_abnormal_hepatobiliary_system4.50696143
3MP0005365_abnormal_bile_salt3.35485232
4MP0005058_abnormal_lysosome_morphology2.94308173
5MP0005085_abnormal_gallbladder_physiolo2.89545232
6MP0008875_abnormal_xenobiotic_pharmacok2.73551386
7MP0003806_abnormal_nucleotide_metabolis2.62286204
8MP0003195_calcinosis2.62052222
9MP0009840_abnormal_foam_cell2.49600239
10MP0002138_abnormal_hepatobiliary_system2.48479453
11MP0005332_abnormal_amino_acid2.47341296
12MP0003252_abnormal_bile_duct2.39891044
13MP0003436_decreased_susceptibility_to2.27663363
14MP0001835_abnormal_antigen_presentation2.27226123
15MP0003191_abnormal_cellular_cholesterol2.24003469
16MP0002419_abnormal_innate_immunity2.15220728
17MP0003724_increased_susceptibility_to2.10257796
18MP0009785_altered_susceptibility_to1.97094890
19MP0003186_abnormal_redox_activity1.97010894
20MP0009697_abnormal_copulation1.90353775
21MP0006082_CNS_inflammation1.89437526
22MP0003172_abnormal_lysosome_physiology1.86559864
23MP0009764_decreased_sensitivity_to1.85332581
24MP0004019_abnormal_vitamin_homeostasis1.83564012
25MP0009643_abnormal_urine_homeostasis1.76190698
26MP0000569_abnormal_digit_pigmentation1.72423378
27MP0010329_abnormal_lipoprotein_level1.69872366
28MP0005083_abnormal_biliary_tract1.62145034
29MP0003763_abnormal_thymus_physiology1.58672901
30MP0003828_pulmonary_edema1.55630750
31MP0008469_abnormal_protein_level1.55097430
32MP0008260_abnormal_autophagy1.54556122
33MP0005025_abnormal_response_to1.54436294
34MP0002148_abnormal_hypersensitivity_rea1.50958870
35MP0002132_abnormal_respiratory_system1.47618220
36MP0005464_abnormal_platelet_physiology1.46621041
37MP0001764_abnormal_homeostasis1.46173130
38MP0002452_abnormal_antigen_presenting1.44972339
39MP0000609_abnormal_liver_physiology1.44063287
40MP0004947_skin_inflammation1.43234762
41MP0003300_gastrointestinal_ulcer1.41250481
42MP0005319_abnormal_enzyme/_coenzyme1.40918766
43MP0000716_abnormal_immune_system1.39815181
44MP0008004_abnormal_stomach_pH1.39769821
45MP0005000_abnormal_immune_tolerance1.39080898
46MP0005387_immune_system_phenotype1.37891302
47MP0001790_abnormal_immune_system1.37891302
48MP0001533_abnormal_skeleton_physiology1.36653592
49MP0005584_abnormal_enzyme/coenzyme_acti1.35970217
50MP0002136_abnormal_kidney_physiology1.31212143
51MP0002398_abnormal_bone_marrow1.30791250
52MP0001800_abnormal_humoral_immune1.30366699
53MP0001845_abnormal_inflammatory_respons1.29766730
54MP0003690_abnormal_glial_cell1.24399251
55MP0009384_cardiac_valve_regurgitation1.24181652
56MP0002723_abnormal_immune_serum1.23553015
57MP0002277_abnormal_respiratory_mucosa1.22645386
58MP0010368_abnormal_lymphatic_system1.22010980
59MP0006054_spinal_hemorrhage1.21435944
60MP0005397_hematopoietic_system_phenotyp1.18702206
61MP0001545_abnormal_hematopoietic_system1.18702206
62MP0004782_abnormal_surfactant_physiolog1.17256909
63MP0000015_abnormal_ear_pigmentation1.16431373
64MP0003303_peritoneal_inflammation1.15982323
65MP0001958_emphysema1.15664914
66MP0003866_abnormal_defecation1.15276183
67MP0001851_eye_inflammation1.14920652
68MP0005310_abnormal_salivary_gland1.14684701
69MP0001879_abnormal_lymphatic_vessel1.14602292
70MP0002722_abnormal_immune_system1.14445853
71MP0000343_altered_response_to1.11797566
72MP0009763_increased_sensitivity_to1.11794937
73MP0010234_abnormal_vibrissa_follicle1.11369281
74MP0003045_fibrosis1.09625635
75MP0005451_abnormal_body_composition1.08175483
76MP0003075_altered_response_to1.08063915
77MP0001819_abnormal_immune_cell1.06969947
78MP0002429_abnormal_blood_cell1.06893229
79MP0002118_abnormal_lipid_homeostasis1.06778952
80MP0009333_abnormal_splenocyte_physiolog1.06650726
81MP0002420_abnormal_adaptive_immunity1.05565552
82MP0005670_abnormal_white_adipose1.03842232
83MP0005084_abnormal_gallbladder_morpholo1.03654643
84MP0002928_abnormal_bile_duct1.03317250
85MP0002998_abnormal_bone_remodeling1.02880157
86MP0001853_heart_inflammation1.01766446
87MP0000685_abnormal_immune_system1.01669315
88MP0005671_abnormal_response_to1.00219677
89MP0000598_abnormal_liver_morphology0.99845529
90MP0003279_aneurysm0.99591242
91MP0004381_abnormal_hair_follicle0.99517743
92MP0002933_joint_inflammation0.99296909
93MP0005164_abnormal_response_to0.97709562
94MP0000767_abnormal_smooth_muscle0.96187602
95MP0002693_abnormal_pancreas_physiology0.96073802
96MP0005636_abnormal_mineral_homeostasis0.94956038
97MP0001756_abnormal_urination0.94679877
98MP0002006_tumorigenesis0.94679439
99MP0005075_abnormal_melanosome_morpholog0.93473804
100MP0005166_decreased_susceptibility_to0.92873824
101MP0003448_altered_tumor_morphology0.91715910
102MP0005379_endocrine/exocrine_gland_phen0.90411225
103MP0005647_abnormal_sex_gland0.88349827
104MP0009278_abnormal_bone_marrow0.88226925
105MP0010155_abnormal_intestine_physiology0.87289342
106MP0000604_amyloidosis0.87074689
107MP0003656_abnormal_erythrocyte_physiolo0.86317198
108MP0002166_altered_tumor_susceptibility0.85365844
109MP0003566_abnormal_cell_adhesion0.84134034
110MP0002168_other_aberrant_phenotype0.83465584
111MP0001666_abnormal_nutrient_absorption0.82883689
112MP0005376_homeostasis/metabolism_phenot0.82467659
113MP0000249_abnormal_blood_vessel0.82321279
114MP0005390_skeleton_phenotype0.80595147
115MP0005174_abnormal_tail_pigmentation0.79300122
116MP0003795_abnormal_bone_structure0.78739999
117MP0002877_abnormal_melanocyte_morpholog0.78693329
118MP0000703_abnormal_thymus_morphology0.78556419
119MP0002163_abnormal_gland_morphology0.78312864
120MP0002135_abnormal_kidney_morphology0.77453301
121MP0002009_preneoplasia0.77084155
122MP0002332_abnormal_exercise_endurance0.74737945
123MP0000371_diluted_coat_color0.74626554
124MP0002396_abnormal_hematopoietic_system0.72661485
125MP0004883_abnormal_blood_vessel0.72322500
126MP0009642_abnormal_blood_homeostasis0.72241525
127MP0005167_abnormal_blood-brain_barrier0.72193188
128MP0001915_intracranial_hemorrhage0.71836993
129MP0002405_respiratory_system_inflammati0.71150281
130MP0004510_myositis0.70829481
131MP0000465_gastrointestinal_hemorrhage0.70773647
132MP0000858_altered_metastatic_potential0.70564213
133MP0000689_abnormal_spleen_morphology0.69966874
134MP0003705_abnormal_hypodermis_morpholog0.69903476
135MP0002254_reproductive_system_inflammat0.69888739
136MP0003183_abnormal_peptide_metabolism0.69821982
137MP0004043_abnormal_pH_regulation0.69537309
138MP0004484_altered_response_of0.68187135

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.70769828
2Myositis (HP:0100614)4.66326076
3Vacuolated lymphocytes (HP:0001922)4.51549406
4Stomatitis (HP:0010280)4.43477862
5Optic neuritis (HP:0100653)4.43457425
6Retrobulbar optic neuritis (HP:0100654)4.43457425
7Abnormality of glycolipid metabolism (HP:0010969)4.14798725
8Abnormality of liposaccharide metabolism (HP:0010968)4.14798725
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.14798725
10Recurrent abscess formation (HP:0002722)4.02038902
11Recurrent gram-negative bacterial infections (HP:0005420)4.01080487
12Recurrent bacterial skin infections (HP:0005406)3.92420421
13Systemic lupus erythematosus (HP:0002725)3.91004444
14Elevated erythrocyte sedimentation rate (HP:0003565)3.80399163
15Intrahepatic cholestasis (HP:0001406)3.75096902
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65115742
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48013049
18Xanthomatosis (HP:0000991)3.41370429
19Joint hemorrhage (HP:0005261)3.34026616
20Hyperglycinuria (HP:0003108)3.33772921
21Recurrent fungal infections (HP:0002841)3.33483119
22Dysostosis multiplex (HP:0000943)3.26115891
23Abnormality of glycine metabolism (HP:0010895)3.23202866
24Abnormality of serine family amino acid metabolism (HP:0010894)3.23202866
25Gastrointestinal infarctions (HP:0005244)3.22197699
26Prolonged partial thromboplastin time (HP:0003645)3.19335301
27Spontaneous hematomas (HP:0007420)3.17683157
28Keratoconjunctivitis sicca (HP:0001097)3.16680293
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.14692793
30Abnormality of proline metabolism (HP:0010907)3.11477610
31Hydroxyprolinuria (HP:0003080)3.11477610
32T lymphocytopenia (HP:0005403)3.10855230
33Urinary glycosaminoglycan excretion (HP:0003541)3.10737004
34Mucopolysacchariduria (HP:0008155)3.10737004
35Complement deficiency (HP:0004431)3.09949108
36Hyperglycinemia (HP:0002154)3.09459345
37Myocardial infarction (HP:0001658)3.07882049
38Abnormality of macrophages (HP:0004311)3.06395462
39Hypoglycemic coma (HP:0001325)3.04367140
40Glomerulonephritis (HP:0000099)3.02354307
41Eczematoid dermatitis (HP:0000976)3.01329781
42Keratoconjunctivitis (HP:0001096)2.99402288
43Abnormality of T cell number (HP:0011839)2.98753201
44Episodic fever (HP:0001954)2.96847985
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94049891
46Arterial thrombosis (HP:0004420)2.92184013
47Vasculitis (HP:0002633)2.92023597
48Abnormality of polysaccharide metabolism (HP:0011012)2.87561195
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87561195
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87561195
51Chronic mucocutaneous candidiasis (HP:0002728)2.87403622
52Recurrent cutaneous fungal infections (HP:0011370)2.87403622
53Prolonged bleeding time (HP:0003010)2.87110179
54Deep venous thrombosis (HP:0002625)2.86002876
55Petechiae (HP:0000967)2.85371091
56Chronic obstructive pulmonary disease (HP:0006510)2.80014963
57Obstructive lung disease (HP:0006536)2.80014963
58Meningitis (HP:0001287)2.79384131
59Pulmonary infiltrates (HP:0002113)2.79074165
60Hyperammonemia (HP:0001987)2.75993367
61Generalized aminoaciduria (HP:0002909)2.73920499
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.73646886
63Ketosis (HP:0001946)2.70990657
64Epistaxis (HP:0000421)2.63853389
65Peritonitis (HP:0002586)2.62970356
66Hypoglycemic seizures (HP:0002173)2.61393044
67Proximal tubulopathy (HP:0000114)2.61046557
68Abnormality of purine metabolism (HP:0004352)2.60919911
69Hyperlipoproteinemia (HP:0010980)2.59623982
70Abnormality of the common coagulation pathway (HP:0010990)2.59339339
71Abnormality of complement system (HP:0005339)2.58785601
72Encephalitis (HP:0002383)2.58653622
73Hemoptysis (HP:0002105)2.55797156
74Increased CSF protein (HP:0002922)2.54385910
75Chest pain (HP:0100749)2.53423869
76Esophageal varix (HP:0002040)2.53413624
77Abnormality of fatty-acid metabolism (HP:0004359)2.51672678
78Anorexia (HP:0002039)2.51123489
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.51073535
80Axonal loss (HP:0003447)2.50591923
81Loss of speech (HP:0002371)2.50430438
82Abnormality of nucleobase metabolism (HP:0010932)2.49450576
83Progressive neurologic deterioration (HP:0002344)2.48102491
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46581720
85Autoimmune thrombocytopenia (HP:0001973)2.44188946
86Epidermoid cyst (HP:0200040)2.43288371
87Conjugated hyperbilirubinemia (HP:0002908)2.41130229
88Increased cerebral lipofuscin (HP:0011813)2.40071027
89Fat malabsorption (HP:0002630)2.37338708
90Enlarged kidneys (HP:0000105)2.37311218
91Pulmonary embolism (HP:0002204)2.37287697
92Abnormality of the intrinsic pathway (HP:0010989)2.35803096
93Nephritis (HP:0000123)2.35382753
94Recurrent skin infections (HP:0001581)2.35214991
95Leukocytosis (HP:0001974)2.33367203
96Abnormality of T cells (HP:0002843)2.32724362
97Nausea (HP:0002018)2.30503217
98Recurrent viral infections (HP:0004429)2.29419727
99Increased IgE level (HP:0003212)2.27782756
100Abnormality of pyrimidine metabolism (HP:0004353)2.26511906
101Gangrene (HP:0100758)2.23090495
102Hypoalphalipoproteinemia (HP:0003233)2.22201515
103Dicarboxylic aciduria (HP:0003215)2.22103812
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22103812
105Chronic diarrhea (HP:0002028)2.18831610
106Anomalous pulmonary venous return (HP:0010772)2.17491609
107Purpura (HP:0000979)2.17078866
108Abnormality of T cell physiology (HP:0011840)2.14436579
109Abnormality of urine glucose concentration (HP:0011016)2.12581764
110Glycosuria (HP:0003076)2.12581764
111Gingival bleeding (HP:0000225)2.11245059
112Joint swelling (HP:0001386)2.09024617
113Ketoacidosis (HP:0001993)2.08999941
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05902617
115Autoimmune hemolytic anemia (HP:0001890)2.05579463
116Tetraparesis (HP:0002273)2.05516466
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05485514
118Hypobetalipoproteinemia (HP:0003563)2.04890229
119Hypolipoproteinemia (HP:0010981)2.04487933
120Pustule (HP:0200039)2.02503799
121Hypochromic microcytic anemia (HP:0004840)2.02307557
122Polyneuropathy (HP:0001271)2.02274302
123Acne (HP:0001061)2.01772030
124Abnormality of the pleura (HP:0002103)2.01638374
125Vascular calcification (HP:0004934)2.00641389
126Periodontitis (HP:0000704)1.99831811
127Osteomyelitis (HP:0002754)1.99742684
128Steatorrhea (HP:0002570)1.99000300
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98486745
130Abnormality of serum amino acid levels (HP:0003112)1.98240980
131Abnormality of methionine metabolism (HP:0010901)1.98035826
132Symptomatic seizures (HP:0011145)1.98024967
133Gingivitis (HP:0000230)1.97854584
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97339622
135Inflammation of the large intestine (HP:0002037)1.96259047
136Acute hepatic failure (HP:0006554)1.95622158
137Recurrent bronchitis (HP:0002837)1.94648351
138Granulocytopenia (HP:0001913)1.93531015
139Thrombophlebitis (HP:0004418)1.93386995
140Pathologic fracture (HP:0002756)1.93151486
141Hematochezia (HP:0002573)1.92759723
142Abnormality of the pericardium (HP:0001697)1.91739857
143Hypercholesterolemia (HP:0003124)1.90473244
144Protuberant abdomen (HP:0001538)1.89276192
145Papilledema (HP:0001085)1.88540179
146Mediastinal lymphadenopathy (HP:0100721)1.88409957
147Abnormality of the lumbar spine (HP:0100712)1.87971567
148Eosinophilia (HP:0001880)1.87509308
149Abnormality of the pulmonary veins (HP:0011718)1.87166974
150Renal tubular acidosis (HP:0001947)1.87132193
151Urticaria (HP:0001025)1.87036825
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86607810
153Cellulitis (HP:0100658)1.86502694
154Albinism (HP:0001022)1.85029356
155Subacute progressive viral hepatitis (HP:0006572)1.84177144
156Methylmalonic aciduria (HP:0012120)1.82783570
157Cardiovascular calcification (HP:0011915)1.82622589
158Keratitis (HP:0000491)1.82298264
159Abnormal tarsal ossification (HP:0008369)1.82286077
160Metabolic acidosis (HP:0001942)1.81945216
161Hypergammaglobulinemia (HP:0010702)1.81574020
162Polyuria (HP:0000103)1.79624685
163Amyloidosis (HP:0011034)1.79224934
164Microcytic anemia (HP:0001935)1.78913081
165Gout (HP:0001997)1.78410517
166Disinhibition (HP:0000734)1.77977287
167Alkalosis (HP:0001948)1.77483859
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77382912
169Sensorimotor neuropathy (HP:0007141)1.76955255
170Hepatosplenomegaly (HP:0001433)1.76137334
171Vertigo (HP:0002321)1.74942874
172Gastrointestinal inflammation (HP:0004386)1.74698194
173Recurrent pneumonia (HP:0006532)1.73777287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.57458818
2TGFBR22.82715824
3MAP3K142.66415887
4MAP2K32.53858057
5ERN12.47236236
6NUAK12.39374429
7TAOK32.32784063
8INSRR2.31577049
9MST42.24869199
10FLT32.21429588
11TEC2.20621447
12IRAK42.20012863
13PBK2.14468647
14RIPK42.08848247
15STK38L2.05874973
16MAP3K22.00106175
17TYK21.96933250
18EPHB11.94775968
19WNK31.87654328
20MUSK1.84519077
21KIT1.83912385
22TBK11.79162562
23GRK71.78716096
24BCKDK1.77101390
25FES1.75747996
26KDR1.70522960
27TIE11.64348405
28GRK61.63145443
29ZAK1.62572055
30PIK3CG1.56774654
31TNK21.47348907
32BRD41.46190065
33CSK1.43560720
34FGFR31.43284098
35CSF1R1.36392807
36MAP3K131.35993488
37STK101.34977929
38TAOK11.33295074
39TXK1.32190238
40BMPR21.31944255
41WNK41.29267985
42NEK91.29162750
43FGR1.28410455
44TRPM71.26620148
45MAP4K11.24961262
46MAP3K11.22665709
47IKBKB1.22248412
48JAK11.21474442
49CDK121.20209690
50MAP3K121.15567085
51BTK1.14982693
52CAMK1D1.10795240
53JAK31.08557666
54MAP2K61.07602662
55EPHA31.02174746
56PTK2B1.01573320
57PRPF4B0.99912231
58LATS10.96578581
59OXSR10.92243803
60LYN0.88115992
61STK30.87116013
62SIK10.85871066
63ERBB40.85357171
64FRK0.85044419
65AKT30.83708893
66EIF2AK30.83400818
67SIK30.82866164
68HIPK20.82611212
69EIF2AK20.82575424
70BMPR1B0.82440239
71YES10.80213358
72FER0.79356895
73PIK3CA0.79041815
74LRRK20.78916497
75BLK0.78890271
76IRAK10.75282081
77CAMKK20.75056797
78MAP3K110.74902127
79STK40.73804482
80JAK20.73405063
81DMPK0.72265437
82ACVR1B0.72182465
83IKBKE0.71329035
84PDK10.69914248
85MAP4K20.69342077
86IGF1R0.68947314
87ZAP700.68205956
88MAP3K30.67139522
89PIM20.66921810
90PIM10.66758133
91IRAK20.66301593
92MAP3K60.64674883
93STK240.64377410
94MST1R0.63008454
95PRKAA20.62779947
96MAP3K50.62587139
97SGK20.62539185
98CDK60.62486449
99PRKD20.61716221
100KSR20.60093795
101MAPK70.59575186
102TAOK20.59178901
103MAPK110.58163076
104MAP3K70.56750092
105PDPK10.56738595
106CLK10.56617769
107ABL20.56390140
108FGFR40.54646542
109CHUK0.53412855
110MOS0.52344517
111HCK0.51654492
112LCK0.51335682
113GRK10.50769394
114MET0.50741565
115ITK0.50201101
116PTK60.48989835
117SYK0.48010618
118PRKCQ0.47578911
119SGK30.47384790
120RPS6KA40.46836960
121DAPK20.46709252
122NLK0.46654086
123EPHA20.45835317
124MAPK150.44907925
125STK380.44547590
126MARK30.44137620
127WNK10.42894645
128ABL10.41861953
129EGFR0.40494623
130ADRBK20.40494252
131MAPKAPK20.38636252
132MELK0.38491110
133PRKCD0.37641512
134MATK0.36873558
135GSK3A0.36721509
136FYN0.35071532
137PAK30.30537753
138STK110.29359925
139RAF10.29282230
140CDC42BPA0.29046444
141MAPK120.28938893
142PRKG20.27509422
143PINK10.27368688

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.25574416
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.24202901
3Caffeine metabolism_Homo sapiens_hsa002322.81835199
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70224579
5Complement and coagulation cascades_Homo sapiens_hsa046102.60016444
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56716388
7Peroxisome_Homo sapiens_hsa041462.44674872
8Fatty acid degradation_Homo sapiens_hsa000712.38924461
9Allograft rejection_Homo sapiens_hsa053302.04251288
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.04110363
11Type I diabetes mellitus_Homo sapiens_hsa049402.02647069
12Other glycan degradation_Homo sapiens_hsa005111.99192371
13Nitrogen metabolism_Homo sapiens_hsa009101.99045834
14Sulfur metabolism_Homo sapiens_hsa009201.93816441
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91564774
16Tryptophan metabolism_Homo sapiens_hsa003801.91115997
17Folate biosynthesis_Homo sapiens_hsa007901.88858774
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81565894
19Autoimmune thyroid disease_Homo sapiens_hsa053201.78933953
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75837741
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73507119
22Lysosome_Homo sapiens_hsa041421.72425627
23Histidine metabolism_Homo sapiens_hsa003401.72358786
24B cell receptor signaling pathway_Homo sapiens_hsa046621.67248372
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63017429
26Arginine biosynthesis_Homo sapiens_hsa002201.62208506
27PPAR signaling pathway_Homo sapiens_hsa033201.59395837
28Steroid biosynthesis_Homo sapiens_hsa001001.57861552
29Fatty acid metabolism_Homo sapiens_hsa012121.57376066
30Propanoate metabolism_Homo sapiens_hsa006401.55766645
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.51816849
32TNF signaling pathway_Homo sapiens_hsa046681.50837445
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45702015
34beta-Alanine metabolism_Homo sapiens_hsa004101.42846905
35Selenocompound metabolism_Homo sapiens_hsa004501.41865738
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41850886
37Vitamin digestion and absorption_Homo sapiens_hsa049771.36144318
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34962444
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.33809618
40Leishmaniasis_Homo sapiens_hsa051401.32999786
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32132205
42Chemokine signaling pathway_Homo sapiens_hsa040621.31998747
43Primary immunodeficiency_Homo sapiens_hsa053401.31157602
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28751035
45T cell receptor signaling pathway_Homo sapiens_hsa046601.27544381
46Starch and sucrose metabolism_Homo sapiens_hsa005001.26613790
47Chemical carcinogenesis_Homo sapiens_hsa052041.21011489
48Hepatitis C_Homo sapiens_hsa051601.15155669
49Platelet activation_Homo sapiens_hsa046111.14411699
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12226079
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.12162892
52Butanoate metabolism_Homo sapiens_hsa006501.11142803
53ABC transporters_Homo sapiens_hsa020101.10822625
54Legionellosis_Homo sapiens_hsa051341.09931786
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09676217
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.06745523
57Malaria_Homo sapiens_hsa051441.06036516
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05123925
59Phenylalanine metabolism_Homo sapiens_hsa003601.04957162
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04214037
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04094522
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.02512595
63Retinol metabolism_Homo sapiens_hsa008301.01146930
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.99452613
65Acute myeloid leukemia_Homo sapiens_hsa052210.99387986
66Hepatitis B_Homo sapiens_hsa051610.99321110
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99138211
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98527000
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96125120
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95483678
71Shigellosis_Homo sapiens_hsa051310.94897432
72Salmonella infection_Homo sapiens_hsa051320.92385037
73Phagosome_Homo sapiens_hsa041450.89665531
74Bile secretion_Homo sapiens_hsa049760.87134825
75Tyrosine metabolism_Homo sapiens_hsa003500.86767289
76Arginine and proline metabolism_Homo sapiens_hsa003300.86267185
77Viral myocarditis_Homo sapiens_hsa054160.86127629
78Pertussis_Homo sapiens_hsa051330.83873520
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.81274556
80Protein export_Homo sapiens_hsa030600.80950145
81Rheumatoid arthritis_Homo sapiens_hsa053230.79898179
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.79604443
83Sphingolipid metabolism_Homo sapiens_hsa006000.78707521
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78404822
85Pyruvate metabolism_Homo sapiens_hsa006200.76755489
86Pentose phosphate pathway_Homo sapiens_hsa000300.76355449
87Fatty acid elongation_Homo sapiens_hsa000620.75808579
88Amoebiasis_Homo sapiens_hsa051460.75784787
89Osteoclast differentiation_Homo sapiens_hsa043800.75700270
90One carbon pool by folate_Homo sapiens_hsa006700.75232317
91Tuberculosis_Homo sapiens_hsa051520.72726278
92Prolactin signaling pathway_Homo sapiens_hsa049170.72311165
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71768232
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71676120
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71269125
96Pancreatic cancer_Homo sapiens_hsa052120.69275441
97Regulation of autophagy_Homo sapiens_hsa041400.69195081
98Non-small cell lung cancer_Homo sapiens_hsa052230.68552751
99Dorso-ventral axis formation_Homo sapiens_hsa043200.68061058
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67969007
101Glutathione metabolism_Homo sapiens_hsa004800.67880682
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.67767430
103Asthma_Homo sapiens_hsa053100.65530615
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63269514
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63213839
106Hematopoietic cell lineage_Homo sapiens_hsa046400.62195620
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62162372
108Apoptosis_Homo sapiens_hsa042100.61812655
109Carbon metabolism_Homo sapiens_hsa012000.61229149
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60646135
111Graft-versus-host disease_Homo sapiens_hsa053320.60556723
112FoxO signaling pathway_Homo sapiens_hsa040680.60109218
113Measles_Homo sapiens_hsa051620.58813427
114Collecting duct acid secretion_Homo sapiens_hsa049660.58036549
115African trypanosomiasis_Homo sapiens_hsa051430.54420407
116Arachidonic acid metabolism_Homo sapiens_hsa005900.53543075
117Herpes simplex infection_Homo sapiens_hsa051680.52616338
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52516430
119Lysine degradation_Homo sapiens_hsa003100.52230163
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52026340
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50890243
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.50798812
123Sulfur relay system_Homo sapiens_hsa041220.49812027
124Renal cell carcinoma_Homo sapiens_hsa052110.49765226
125Endocytosis_Homo sapiens_hsa041440.49580249
126Type II diabetes mellitus_Homo sapiens_hsa049300.48307471
127Insulin resistance_Homo sapiens_hsa049310.47831357
128Fatty acid biosynthesis_Homo sapiens_hsa000610.47294205
129VEGF signaling pathway_Homo sapiens_hsa043700.46783380
130mTOR signaling pathway_Homo sapiens_hsa041500.46685366
131Metabolic pathways_Homo sapiens_hsa011000.46326296
132Inositol phosphate metabolism_Homo sapiens_hsa005620.44738803
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44331301
134Antigen processing and presentation_Homo sapiens_hsa046120.43169247
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42566472
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41952375
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40553569
138Galactose metabolism_Homo sapiens_hsa000520.39720302
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39112037
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38744610
141Chronic myeloid leukemia_Homo sapiens_hsa052200.37042923
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35872879
143Influenza A_Homo sapiens_hsa051640.35669967
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35236793
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34951971
146Mineral absorption_Homo sapiens_hsa049780.33528493
147Toxoplasmosis_Homo sapiens_hsa051450.33092281
148Fructose and mannose metabolism_Homo sapiens_hsa000510.32705342
149HIF-1 signaling pathway_Homo sapiens_hsa040660.32194041
150Viral carcinogenesis_Homo sapiens_hsa052030.31692124
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.29933254
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.29614426
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25172205

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