CTDSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.25982588
2negative regulation of cell killing (GO:0031342)5.25982588
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19658118
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11273963
5antigen processing and presentation of endogenous antigen (GO:0019883)5.06349350
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03029349
7L-phenylalanine catabolic process (GO:0006559)5.03029349
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.98059619
9L-phenylalanine metabolic process (GO:0006558)4.98059619
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.71274869
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70414293
12alpha-linolenic acid metabolic process (GO:0036109)4.60200308
13aromatic amino acid family catabolic process (GO:0009074)4.56181424
14glyoxylate metabolic process (GO:0046487)4.49342787
15positive regulation of gamma-delta T cell activation (GO:0046645)4.46702607
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37122467
17lysine metabolic process (GO:0006553)4.36862801
18lysine catabolic process (GO:0006554)4.36862801
19positive regulation by symbiont of host defense response (GO:0052509)4.36487283
20modulation by symbiont of host defense response (GO:0052031)4.36487283
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36487283
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36487283
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.36487283
24modulation by symbiont of host immune response (GO:0052553)4.36487283
25kynurenine metabolic process (GO:0070189)4.34066883
26sulfur amino acid catabolic process (GO:0000098)4.28548763
27detection of other organism (GO:0098543)4.28079370
28detection of bacterium (GO:0016045)4.27389337
29protein carboxylation (GO:0018214)4.24815440
30peptidyl-glutamic acid carboxylation (GO:0017187)4.24815440
31negative regulation of erythrocyte differentiation (GO:0045647)4.24707921
32complement activation, alternative pathway (GO:0006957)4.17443166
33tryptophan catabolic process (GO:0006569)4.16055023
34indole-containing compound catabolic process (GO:0042436)4.16055023
35indolalkylamine catabolic process (GO:0046218)4.16055023
36cysteine metabolic process (GO:0006534)4.11380270
37negative regulation of fibrinolysis (GO:0051918)4.03649064
38regulation of triglyceride catabolic process (GO:0010896)3.97233154
39tryptophan metabolic process (GO:0006568)3.95135014
40urea metabolic process (GO:0019627)3.95001175
41urea cycle (GO:0000050)3.95001175
42neutrophil activation involved in immune response (GO:0002283)3.94784470
43bile acid biosynthetic process (GO:0006699)3.88563728
44high-density lipoprotein particle remodeling (GO:0034375)3.83195550
45regulation of protein activation cascade (GO:2000257)3.80388428
46response to peptidoglycan (GO:0032494)3.76973143
47plasma lipoprotein particle clearance (GO:0034381)3.76724935
48amino-acid betaine metabolic process (GO:0006577)3.73359855
49leukocyte aggregation (GO:0070486)3.68686665
50regulation of fibrinolysis (GO:0051917)3.66604813
51nitrogen cycle metabolic process (GO:0071941)3.65484558
52valine metabolic process (GO:0006573)3.63115722
53regulation of complement activation (GO:0030449)3.61895842
54phospholipid efflux (GO:0033700)3.61712403
55negative regulation of cholesterol transport (GO:0032375)3.61479731
56negative regulation of sterol transport (GO:0032372)3.61479731
57regulation of cholesterol homeostasis (GO:2000188)3.60247864
58macrophage activation involved in immune response (GO:0002281)3.57299990
59detection of external biotic stimulus (GO:0098581)3.56883011
60homocysteine metabolic process (GO:0050667)3.55888624
61serine family amino acid catabolic process (GO:0009071)3.55272124
62ethanol oxidation (GO:0006069)3.53114413
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.48681629
642-oxoglutarate metabolic process (GO:0006103)3.46478018
65regulation of gamma-delta T cell activation (GO:0046643)3.44697860
66reverse cholesterol transport (GO:0043691)3.44650821
67fatty acid beta-oxidation (GO:0006635)3.42155836
68positive regulation of lipid catabolic process (GO:0050996)3.40073074
69regulation of cholesterol esterification (GO:0010872)3.38950406
70protein-lipid complex remodeling (GO:0034368)3.32897788
71macromolecular complex remodeling (GO:0034367)3.32897788
72plasma lipoprotein particle remodeling (GO:0034369)3.32897788
73phospholipid homeostasis (GO:0055091)3.32514102
74bile acid metabolic process (GO:0008206)3.31849953
75mannose metabolic process (GO:0006013)3.29792927
76fatty acid oxidation (GO:0019395)3.27262823
77acylglycerol homeostasis (GO:0055090)3.27234530
78triglyceride homeostasis (GO:0070328)3.27234530
79cellular extravasation (GO:0045123)3.23002734
80plasma lipoprotein particle assembly (GO:0034377)3.21981923
81lipid oxidation (GO:0034440)3.20956788
82alpha-amino acid catabolic process (GO:1901606)3.19702105
83regulation of gamma-delta T cell differentiation (GO:0045586)3.18910551
84aromatic amino acid family metabolic process (GO:0009072)3.18909534
85positive regulation of triglyceride lipase activity (GO:0061365)3.18549098
86positive regulation of lipoprotein lipase activity (GO:0051006)3.18549098
87cellular modified amino acid catabolic process (GO:0042219)3.18263630
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.17495633
89positive regulation of triglyceride metabolic process (GO:0090208)3.16564939
90regulation of fatty acid beta-oxidation (GO:0031998)3.13123303
91regulation of B cell receptor signaling pathway (GO:0050855)3.11988652
92acetyl-CoA metabolic process (GO:0006084)3.11827904
93detection of biotic stimulus (GO:0009595)3.11121567
94carnitine metabolic process (GO:0009437)3.07232989
95regulation of mast cell degranulation (GO:0043304)3.07146546
96immunoglobulin mediated immune response (GO:0016064)3.06885269
97positive thymic T cell selection (GO:0045059)3.06666735
98protein-lipid complex assembly (GO:0065005)3.06404634
99low-density lipoprotein particle clearance (GO:0034383)3.06229291
100glycine metabolic process (GO:0006544)3.06217442
101fatty acid catabolic process (GO:0009062)3.05857056
102detection of molecule of bacterial origin (GO:0032490)3.05528837
103cellular ketone body metabolic process (GO:0046950)3.04751895
104short-chain fatty acid metabolic process (GO:0046459)3.04703544
105aspartate family amino acid catabolic process (GO:0009068)3.04003354
106cholesterol efflux (GO:0033344)3.03606863
107tyrosine metabolic process (GO:0006570)3.03582304
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03316858
109regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03129931
110cholesterol homeostasis (GO:0042632)3.01566399
111antigen processing and presentation via MHC class Ib (GO:0002475)3.00463362
112cellular amino acid catabolic process (GO:0009063)3.00217487
113negative regulation of leukocyte mediated immunity (GO:0002704)2.99253905
114fibrinolysis (GO:0042730)2.99180173
115sterol homeostasis (GO:0055092)2.98765665
116monocarboxylic acid catabolic process (GO:0072329)2.98168401
117benzene-containing compound metabolic process (GO:0042537)2.98141882
118regulation of leukocyte degranulation (GO:0043300)2.97662617
119leukocyte migration involved in inflammatory response (GO:0002523)2.94842749
120cellular glucuronidation (GO:0052695)2.94820939
121regulation of interferon-beta biosynthetic process (GO:0045357)2.94634027
122serine family amino acid metabolic process (GO:0009069)2.94404909
123regulation of cholesterol storage (GO:0010885)2.93781027
124negative regulation of interleukin-12 production (GO:0032695)2.93170056
125fatty acid transmembrane transport (GO:1902001)2.93099418
126response to muramyl dipeptide (GO:0032495)2.93027878
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91158868
128regulation of T-helper 2 cell differentiation (GO:0045628)2.90234348
129neutrophil activation (GO:0042119)2.89797292
130acute-phase response (GO:0006953)2.88965782
131germinal center formation (GO:0002467)2.88880606
132bile acid and bile salt transport (GO:0015721)2.86850163
133regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86783425
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86750020
135response to host immune response (GO:0052572)2.86750020
136positive regulation of fatty acid oxidation (GO:0046321)2.86509523
137ethanol metabolic process (GO:0006067)2.86441324
138dicarboxylic acid biosynthetic process (GO:0043650)2.86405895
139lipoprotein metabolic process (GO:0042157)2.85861994
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.84946435
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84912798
142response to host (GO:0075136)2.84912798
143response to host defenses (GO:0052200)2.84912798
144regulation of triglyceride metabolic process (GO:0090207)2.84383625
145complement activation (GO:0006956)2.82751579
146carboxylic acid catabolic process (GO:0046395)2.82444199
147organic acid catabolic process (GO:0016054)2.82444199
148response to interleukin-15 (GO:0070672)2.82283402
149regulation of cholesterol metabolic process (GO:0090181)2.81066357
150response to laminar fluid shear stress (GO:0034616)2.80868361
151tricarboxylic acid metabolic process (GO:0072350)2.79126106
152indolalkylamine metabolic process (GO:0006586)2.78222591
153drug transmembrane transport (GO:0006855)2.77932380
154negative regulation of phagocytosis (GO:0050765)2.77896485
155plasma lipoprotein particle organization (GO:0071827)2.77747803
156respiratory burst (GO:0045730)2.76544846
157regulation of T cell tolerance induction (GO:0002664)2.74669178
158thymic T cell selection (GO:0045061)2.72130446
159regulation of mast cell activation involved in immune response (GO:0033006)2.71094228
160pinocytosis (GO:0006907)2.70291292
161regulation of extracellular matrix disassembly (GO:0010715)2.69498841
162granulocyte activation (GO:0036230)2.68366801
163B cell receptor signaling pathway (GO:0050853)2.67963899
164response to type I interferon (GO:0034340)2.67421162
165cellular response to type I interferon (GO:0071357)2.66322161
166type I interferon signaling pathway (GO:0060337)2.66322161
167negative regulation of innate immune response (GO:0045824)2.65816798
168negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65745365
169negative thymic T cell selection (GO:0045060)2.64865082
170regulation of tolerance induction (GO:0002643)2.61260023
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61202710
172negative regulation of cytokine production involved in immune response (GO:0002719)2.58946877
173T cell selection (GO:0045058)2.58625660
174myeloid cell activation involved in immune response (GO:0002275)2.51338517
175macrophage activation (GO:0042116)2.48949076
176positive regulation of B cell differentiation (GO:0045579)2.48532514
177negative T cell selection (GO:0043383)2.48470264
178barbed-end actin filament capping (GO:0051016)2.47026629
179positive regulation of cellular amide metabolic process (GO:0034250)2.45814974
180negative regulation of T cell mediated immunity (GO:0002710)2.44850218
181negative regulation of type 2 immune response (GO:0002829)2.41098737
182regulation of regulated secretory pathway (GO:1903305)2.38869248
183regulation of natural killer cell mediated immunity (GO:0002715)2.38131715
184regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.38131715
185NIK/NF-kappaB signaling (GO:0038061)2.37456420
186modulation by symbiont of host cellular process (GO:0044068)2.37113166
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36873673
188regulation of superoxide anion generation (GO:0032928)2.36683131
189regulation of B cell differentiation (GO:0045577)2.36431557
190positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34424298
191negative regulation of interleukin-6 production (GO:0032715)2.34345663
192modulation by virus of host process (GO:0019054)2.34314118
193positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.33708593
194interferon-gamma-mediated signaling pathway (GO:0060333)2.33417432
195negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33219287
196regulation of antigen processing and presentation (GO:0002577)2.32963087
197microglial cell activation (GO:0001774)2.31194337
198tolerance induction (GO:0002507)2.31189703
199positive regulation of extracellular matrix organization (GO:1903055)2.30455426
200positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30214469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.48790447
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.37725696
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05712662
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93785436
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.25775170
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.52461295
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12130924
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.79643072
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68401022
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.45143983
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37444625
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.27165482
13CLOCK_20551151_ChIP-Seq_293T_Human2.24014265
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21408368
15* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08509688
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07809391
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92402778
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90435343
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.87200963
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79589305
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74221553
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73208624
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67732351
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63301189
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62909514
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60667356
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59662440
28SPI1_23547873_ChIP-Seq_NB4_Human1.59104968
29VDR_21846776_ChIP-Seq_THP-1_Human1.56930331
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55083471
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51870180
32* LXR_22292898_ChIP-Seq_THP-1_Human1.51352863
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50900198
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50898160
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50873015
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48972990
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48252962
38* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47250557
39* MYC_22102868_ChIP-Seq_BL_Human1.43462187
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43254399
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42573385
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41361047
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41280265
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.40575969
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40139198
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38985408
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38831500
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.38127818
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36995085
50GATA1_22025678_ChIP-Seq_K562_Human1.35970580
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35903268
52* TCF7_22412390_ChIP-Seq_EML_Mouse1.35282278
53* MAF_26560356_Chip-Seq_TH1_Human1.34954572
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34578088
55SCL_19346495_ChIP-Seq_HPC-7_Human1.32884216
56* SA1_27219007_Chip-Seq_ERYTHROID_Human1.31944229
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.30293198
58KDM2B_26808549_Chip-Seq_K562_Human1.27174369
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26597316
60MYB_26560356_Chip-Seq_TH2_Human1.26484447
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26016677
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25521270
63* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25462694
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24975717
65P68_20966046_ChIP-Seq_HELA_Human1.22493612
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.21593413
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.21460021
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.19870799
69BCL6_27268052_Chip-Seq_Bcells_Human1.19419235
70* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19225560
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19128745
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18754211
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18453829
74* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15272906
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14932636
76ZNF263_19887448_ChIP-Seq_K562_Human1.14740023
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.14531403
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.14531403
79VDR_24763502_ChIP-Seq_THP-1_Human1.14242553
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14173279
81* KDM2B_26808549_Chip-Seq_DND41_Human1.13012192
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12646441
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.11915642
84* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10839578
85* UTX_26944678_Chip-Seq_JUKART_Human1.10015703
86SMC4_20622854_ChIP-Seq_HELA_Human1.09105300
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.08837392
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08836820
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08035269
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.07336678
91* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07044510
92GATA1_19941826_ChIP-Seq_K562_Human1.06815666
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06692973
94* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05740193
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05553421
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04855326
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.03815627
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02707168
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01859022
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01146832
101GATA4_25053715_ChIP-Seq_YYC3_Human1.00005927
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99917987
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99715972
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99250744
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97991814
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97355529
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97326897
108GATA6_25053715_ChIP-Seq_YYC3_Human0.97149762
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97130380
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96835747
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96635342
112ATF3_27146783_Chip-Seq_COLON_Human0.95666035
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94515919
114* NCOR1_26117541_ChIP-Seq_K562_Human0.93123516
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93016579
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90415638
117* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90271277
118* GATA2_21666600_ChIP-Seq_HMVEC_Human0.90235322
119GATA2_19941826_ChIP-Seq_K562_Human0.88638046
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87129289
121* RUNX1_22412390_ChIP-Seq_EML_Mouse0.86647211
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.86443858
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.86379114
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84814612
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84656807
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83448255
127MAF_26560356_Chip-Seq_TH2_Human0.82351298
128* MYB_26560356_Chip-Seq_TH1_Human0.81344133
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81191534
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79625367
131BCOR_27268052_Chip-Seq_Bcells_Human0.78455284
132* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78098359
133RUNX_20019798_ChIP-Seq_JUKART_Human0.77757416
134SPI1_23127762_ChIP-Seq_K562_Human0.76031526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.30503078
2MP0005360_urolithiasis5.07095833
3MP0005085_abnormal_gallbladder_physiolo3.85131525
4MP0005365_abnormal_bile_salt3.85049085
5MP0008875_abnormal_xenobiotic_pharmacok3.05917286
6MP0009840_abnormal_foam_cell2.98141882
7MP0003252_abnormal_bile_duct2.84720304
8MP0003705_abnormal_hypodermis_morpholog2.63039588
9MP0003191_abnormal_cellular_cholesterol2.62368467
10MP0010329_abnormal_lipoprotein_level2.49320940
11MP0003806_abnormal_nucleotide_metabolis2.42414914
12MP0005083_abnormal_biliary_tract2.28764942
13MP0005000_abnormal_immune_tolerance2.14241123
14MP0008260_abnormal_autophagy2.04887187
15MP0005332_abnormal_amino_acid1.92602389
16MP0003763_abnormal_thymus_physiology1.87842490
17MP0001666_abnormal_nutrient_absorption1.87666143
18MP0005671_abnormal_response_to1.86243917
19MP0002723_abnormal_immune_serum1.85752985
20MP0002420_abnormal_adaptive_immunity1.84037274
21MP0003172_abnormal_lysosome_physiology1.82622982
22MP0001819_abnormal_immune_cell1.82292145
23MP0000609_abnormal_liver_physiology1.79673089
24MP0002452_abnormal_antigen_presenting1.79239036
25MP0002138_abnormal_hepatobiliary_system1.77669575
26MP0002132_abnormal_respiratory_system1.76744465
27MP0008438_abnormal_cutaneous_collagen1.72424556
28MP0009333_abnormal_splenocyte_physiolog1.70835653
29MP0003195_calcinosis1.69412465
30MP0003828_pulmonary_edema1.62781011
31MP0002148_abnormal_hypersensitivity_rea1.61570630
32MP0003300_gastrointestinal_ulcer1.58831049
33MP0000858_altered_metastatic_potential1.58280453
34MP0005319_abnormal_enzyme/_coenzyme1.58271436
35MP0002405_respiratory_system_inflammati1.57078693
36MP0002118_abnormal_lipid_homeostasis1.52924759
37MP0000465_gastrointestinal_hemorrhage1.51299751
38MP0003436_decreased_susceptibility_to1.50520005
39MP0002998_abnormal_bone_remodeling1.46391793
40MP0002398_abnormal_bone_marrow1.43316321
41MP0010368_abnormal_lymphatic_system1.43116993
42MP0003866_abnormal_defecation1.43083309
43MP0003183_abnormal_peptide_metabolism1.41381808
44MP0009643_abnormal_urine_homeostasis1.40617219
45MP0004019_abnormal_vitamin_homeostasis1.40088066
46MP0000716_abnormal_immune_system1.39001016
47MP0002396_abnormal_hematopoietic_system1.37533331
48MP0001851_eye_inflammation1.30562008
49MP0003075_altered_response_to1.29070342
50MP0003303_peritoneal_inflammation1.28232058
51MP0005670_abnormal_white_adipose1.27027456
52MP0003656_abnormal_erythrocyte_physiolo1.24992119
53MP0005058_abnormal_lysosome_morphology1.24636261
54MP0002933_joint_inflammation1.23782501
55MP0005584_abnormal_enzyme/coenzyme_acti1.21519996
56MP0001873_stomach_inflammation1.21492627
57MP0005451_abnormal_body_composition1.20476074
58MP0004858_abnormal_nervous_system1.20109492
59MP0004130_abnormal_muscle_cell1.20078695
60MP0002722_abnormal_immune_system1.18560396
61MP0002837_dystrophic_cardiac_calcinosis1.18395202
62MP0003566_abnormal_cell_adhesion1.18036571
63MP0005076_abnormal_cell_differentiation1.16599422
64MP0002429_abnormal_blood_cell1.16414929
65MP0005666_abnormal_adipose_tissue1.14682831
66MP0003724_increased_susceptibility_to1.14252627
67MP0004883_abnormal_blood_vessel1.12534479
68MP0000689_abnormal_spleen_morphology1.12371381
69MP0009278_abnormal_bone_marrow1.12154797
70MP0000598_abnormal_liver_morphology1.12052750
71MP0008469_abnormal_protein_level1.11415158
72MP0003091_abnormal_cell_migration1.10823043
73MP0005464_abnormal_platelet_physiology1.10423381
74MP0000685_abnormal_immune_system1.09567771
75MP0008004_abnormal_stomach_pH1.09536471
76MP0009764_decreased_sensitivity_to1.08689335
77MP0004381_abnormal_hair_follicle1.08434002
78MP0005164_abnormal_response_to1.07115420
79MP0004185_abnormal_adipocyte_glucose1.06884122
80MP0003186_abnormal_redox_activity1.06209760
81MP0005166_decreased_susceptibility_to1.05866304
82MP0005390_skeleton_phenotype1.04246865
83MP0000703_abnormal_thymus_morphology1.04174534
84MP0001849_ear_inflammation1.03094156
85MP0001835_abnormal_antigen_presentation0.99828121
86MP0005409_darkened_coat_color0.99733428
87MP0005275_abnormal_skin_tensile0.98990007
88MP0009763_increased_sensitivity_to0.97651659
89MP0005023_abnormal_wound_healing0.97241446
90MP0006082_CNS_inflammation0.96054325
91MP0009785_altered_susceptibility_to0.95593061
92MP0003279_aneurysm0.95481930
93MP0005025_abnormal_response_to0.94110911
94MP0002254_reproductive_system_inflammat0.92770256
95MP0004947_skin_inflammation0.92039684
96MP0002419_abnormal_innate_immunity0.91065220
97MP0000343_altered_response_to0.88729539
98MP0001663_abnormal_digestive_system0.87456912
99MP0000490_abnormal_crypts_of0.86466894
100MP0004264_abnormal_extraembryonic_tissu0.86302310
101MP0001790_abnormal_immune_system0.85460423
102MP0005387_immune_system_phenotype0.85460423
103MP0001533_abnormal_skeleton_physiology0.84953617
104MP0002136_abnormal_kidney_physiology0.84380297
105MP0003448_altered_tumor_morphology0.84375671
106MP0003690_abnormal_glial_cell0.84143403
107MP0002060_abnormal_skin_morphology0.84097879
108MP0002166_altered_tumor_susceptibility0.83591052
109MP0005310_abnormal_salivary_gland0.82723747
110MP0001845_abnormal_inflammatory_respons0.81507822
111MP0002971_abnormal_brown_adipose0.81378338
112MP0003868_abnormal_feces_composition0.80402920
113MP0003795_abnormal_bone_structure0.80059093
114MP0005330_cardiomyopathy0.79980393
115MP0010630_abnormal_cardiac_muscle0.79950531
116MP0009053_abnormal_anal_canal0.78844561
117MP0001853_heart_inflammation0.78629096
118MP0001958_emphysema0.78215315
119MP0006054_spinal_hemorrhage0.77790936
120MP0005167_abnormal_blood-brain_barrier0.76221764
121MP0000767_abnormal_smooth_muscle0.75865948
122MP0010155_abnormal_intestine_physiology0.75111856
123MP0001756_abnormal_urination0.74820635
124MP0000249_abnormal_blood_vessel0.73776641
125MP0005636_abnormal_mineral_homeostasis0.72857351
126MP0004084_abnormal_cardiac_muscle0.72186428
127MP0009642_abnormal_blood_homeostasis0.71391092
128MP0001800_abnormal_humoral_immune0.71330642
129MP0005375_adipose_tissue_phenotype0.71193454
130MP0004087_abnormal_muscle_fiber0.70492033
131MP0001764_abnormal_homeostasis0.70006707
132MP0003453_abnormal_keratinocyte_physiol0.69406059
133MP0005397_hematopoietic_system_phenotyp0.69301366
134MP0001545_abnormal_hematopoietic_system0.69301366
135MP0010352_gastrointestinal_tract_polyps0.68714748
136MP0000604_amyloidosis0.67999762
137MP0003011_delayed_dark_adaptation0.66854727
138MP0005334_abnormal_fat_pad0.66582371
139MP0004272_abnormal_basement_membrane0.65712702
140MP0002796_impaired_skin_barrier0.65286219
141MP0001879_abnormal_lymphatic_vessel0.64782238
142MP0009115_abnormal_fat_cell0.64130044
143MP0009384_cardiac_valve_regurgitation0.63421144
144MP0005385_cardiovascular_system_phenoty0.63297055
145MP0001544_abnormal_cardiovascular_syste0.63297055
146MP0001243_abnormal_dermal_layer0.62136243
147MP0004510_myositis0.62030109
148MP0002128_abnormal_blood_circulation0.61944725

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.39503788
2Xanthomatosis (HP:0000991)4.67068025
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.49902795
4Intrahepatic cholestasis (HP:0001406)4.48648699
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.33811510
6Complement deficiency (HP:0004431)4.14085551
7Recurrent abscess formation (HP:0002722)4.12938332
8Abnormality of macrophages (HP:0004311)4.07419407
9Myositis (HP:0100614)4.00773466
10Prolonged partial thromboplastin time (HP:0003645)3.69769985
11Hyperlipoproteinemia (HP:0010980)3.67122747
12Hypobetalipoproteinemia (HP:0003563)3.65484541
13Joint hemorrhage (HP:0005261)3.53457912
14Orchitis (HP:0100796)3.51987455
15Hyperammonemia (HP:0001987)3.50957377
16Hypoglycemic coma (HP:0001325)3.41988279
17Ketosis (HP:0001946)3.38970076
18Abnormality of complement system (HP:0005339)3.32788624
19Abnormality of the common coagulation pathway (HP:0010990)3.31025767
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23526907
21Prolonged bleeding time (HP:0003010)3.16542894
22Abnormality of fatty-acid metabolism (HP:0004359)3.16402776
23Elevated erythrocyte sedimentation rate (HP:0003565)3.15525877
24Systemic lupus erythematosus (HP:0002725)3.14374873
25Hyperglycinuria (HP:0003108)3.13884259
26Gastrointestinal infarctions (HP:0005244)3.11555187
27Increased IgE level (HP:0003212)3.10230212
28Hypolipoproteinemia (HP:0010981)3.06774683
29Myocardial infarction (HP:0001658)3.05383721
30Cellulitis (HP:0100658)3.00984210
31Chronic obstructive pulmonary disease (HP:0006510)3.00661226
32Obstructive lung disease (HP:0006536)3.00661226
33Hypoalphalipoproteinemia (HP:0003233)3.00584618
34Purpura (HP:0000979)2.95726269
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91014723
36Abnormality of glycine metabolism (HP:0010895)2.90485099
37Abnormality of serine family amino acid metabolism (HP:0010894)2.90485099
38Gingivitis (HP:0000230)2.87468818
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.86621219
40Optic neuritis (HP:0100653)2.86393665
41Retrobulbar optic neuritis (HP:0100654)2.86393665
42Meningitis (HP:0001287)2.84186525
43Epidermoid cyst (HP:0200040)2.82448126
44Recurrent gram-negative bacterial infections (HP:0005420)2.82144776
45Mediastinal lymphadenopathy (HP:0100721)2.77532552
46Hypercholesterolemia (HP:0003124)2.72397596
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70402858
48Recurrent fungal infections (HP:0002841)2.70316580
49Ketoacidosis (HP:0001993)2.68270170
50Hyperglycinemia (HP:0002154)2.63975781
51Abnormality of the intrinsic pathway (HP:0010989)2.59353487
52Recurrent skin infections (HP:0001581)2.55642924
53Fat malabsorption (HP:0002630)2.54566157
54Esophageal varix (HP:0002040)2.51548218
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51083176
56Stomatitis (HP:0010280)2.49949140
57Abnormality of purine metabolism (HP:0004352)2.46407750
58Pustule (HP:0200039)2.44651834
59Gastrointestinal inflammation (HP:0004386)2.43325263
60Vasculitis (HP:0002633)2.42869685
61Glomerulonephritis (HP:0000099)2.41638701
62Dicarboxylic aciduria (HP:0003215)2.39358797
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39358797
64Polycythemia (HP:0001901)2.38989258
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.38680423
66Abnormality of nucleobase metabolism (HP:0010932)2.37103506
67Colitis (HP:0002583)2.36480446
68Petechiae (HP:0000967)2.36385797
69Urticaria (HP:0001025)2.36127878
70Inflammation of the large intestine (HP:0002037)2.34790296
71Hepatocellular carcinoma (HP:0001402)2.34462099
72Mitral stenosis (HP:0001718)2.33056260
73Dysostosis multiplex (HP:0000943)2.32232311
74Hyperbilirubinemia (HP:0002904)2.30570673
75Encephalitis (HP:0002383)2.27857971
76Hypochromic anemia (HP:0001931)2.23524335
77Chest pain (HP:0100749)2.23336971
78Right ventricular cardiomyopathy (HP:0011663)2.21373144
79Myoglobinuria (HP:0002913)2.20484797
80Peritonitis (HP:0002586)2.20347749
81Hemorrhage of the eye (HP:0011885)2.20328018
82Gout (HP:0001997)2.19718393
83Abnormality of methionine metabolism (HP:0010901)2.19224906
84Skin nodule (HP:0200036)2.18774890
85Abnormality of pyrimidine metabolism (HP:0004353)2.18495017
86Spontaneous hematomas (HP:0007420)2.18332729
87Gingival bleeding (HP:0000225)2.18010517
88Keratoconjunctivitis sicca (HP:0001097)2.16891278
89Nephritis (HP:0000123)2.15815754
90Vascular calcification (HP:0004934)2.14742308
91Generalized aminoaciduria (HP:0002909)2.14673663
92Abnormal cartilage morphology (HP:0002763)2.13624867
93Autoimmune thrombocytopenia (HP:0001973)2.13529450
94Axonal loss (HP:0003447)2.13113690
95Late onset (HP:0003584)2.12531956
96Protrusio acetabuli (HP:0003179)2.12433388
97Increased cerebral lipofuscin (HP:0011813)2.11997541
98Spastic diplegia (HP:0001264)2.10452132
99Abnormality of the peritoneum (HP:0002585)2.09555102
100Cardiovascular calcification (HP:0011915)2.08926030
101Cerebral aneurysm (HP:0004944)2.08477934
102Abnormality of iron homeostasis (HP:0011031)2.08175653
103Metabolic acidosis (HP:0001942)2.07736210
104Vertebral compression fractures (HP:0002953)2.07728115
105Episodic fever (HP:0001954)2.06437052
106Increased connective tissue (HP:0009025)2.05306590
107Pulmonary infiltrates (HP:0002113)2.04444084
108Eczematoid dermatitis (HP:0000976)2.03716359
109Recurrent viral infections (HP:0004429)2.03512375
110Polygenic inheritance (HP:0010982)2.02301188
111Cholelithiasis (HP:0001081)2.02085672
112Asymmetric septal hypertrophy (HP:0001670)2.01433177
113Segmental peripheral demyelination/remyelination (HP:0003481)2.00264280
114Emphysema (HP:0002097)2.00124412
115Osteomyelitis (HP:0002754)1.99436222
116Thin bony cortex (HP:0002753)1.99102501
117Amyloidosis (HP:0011034)1.99101996
118Dilatation of the ascending aorta (HP:0005111)1.99098342
119Menorrhagia (HP:0000132)1.98694932
120Recurrent cutaneous fungal infections (HP:0011370)1.98375912
121Chronic mucocutaneous candidiasis (HP:0002728)1.98375912
122Nausea (HP:0002018)1.97618171
123Increased serum ferritin (HP:0003281)1.97406417
124Abnormality of glycolipid metabolism (HP:0010969)1.97097662
125Abnormality of liposaccharide metabolism (HP:0010968)1.97097662
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.97097662
127Lymphangioma (HP:0100764)1.96621692
128Abnormality of transition element cation homeostasis (HP:0011030)1.95172928
129Ventricular tachycardia (HP:0004756)1.93677214
130Hemoptysis (HP:0002105)1.93660701
131Arterial thrombosis (HP:0004420)1.93647429
132Delayed CNS myelination (HP:0002188)1.93110141
133Keratoconjunctivitis (HP:0001096)1.92693728
134Abnormality of proline metabolism (HP:0010907)1.92613242
135Hydroxyprolinuria (HP:0003080)1.92613242
136Loss of speech (HP:0002371)1.91688678
137Mucopolysacchariduria (HP:0008155)1.91222982
138Urinary glycosaminoglycan excretion (HP:0003541)1.91222982
139Abnormal gallbladder morphology (HP:0012437)1.91165245
140Abnormality of polysaccharide metabolism (HP:0011012)1.90546108
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90546108
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90546108
143Malnutrition (HP:0004395)1.89512592
144Steatorrhea (HP:0002570)1.88877458
145Gastrointestinal stroma tumor (HP:0100723)1.88587561
146Interstitial pulmonary disease (HP:0006530)1.87189193
147Thrombophlebitis (HP:0004418)1.85646027
148Increased mean platelet volume (HP:0011877)1.85353218
149Increased variability in muscle fiber diameter (HP:0003557)1.84824398
150Metaphyseal cupping (HP:0003021)1.84010247
151Rhabdomyolysis (HP:0003201)1.82454651
152Aneurysm (HP:0002617)1.82387952
153Abnormal platelet volume (HP:0011876)1.80702450
154Abnormality of the nasal mucosa (HP:0000433)1.80511476
155Hypochromic microcytic anemia (HP:0004840)1.80298402
156Hepatosplenomegaly (HP:0001433)1.79945218
157Granulocytopenia (HP:0001913)1.79763546
158Pancreatitis (HP:0001733)1.78716133
159Hypergammaglobulinemia (HP:0010702)1.78467344
160Abnormal platelet function (HP:0011869)1.77946190
161Impaired platelet aggregation (HP:0003540)1.77946190
162Aortic aneurysm (HP:0004942)1.77258914
163Increased neuronal autofluorescent lipopigment (HP:0002074)1.77037399
164Hypertriglyceridemia (HP:0002155)1.76029339
165Neonatal onset (HP:0003623)1.73042561
166Broad metatarsal (HP:0001783)1.72202606
167Pulmonary embolism (HP:0002204)1.71275559
168Exercise-induced muscle cramps (HP:0003710)1.69610364
169Abnormal enzyme/coenzyme activity (HP:0012379)1.68340975
170Abnormality of the Achilles tendon (HP:0005109)1.67487672
171Epistaxis (HP:0000421)1.66688715
172Recurrent bacterial skin infections (HP:0005406)1.66517364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.26913754
2ERN14.24567837
3PKN23.46150443
4BCKDK3.24438585
5RIPK43.21822108
6PRPF4B3.08663755
7SIK12.68517628
8TTN2.54184841
9FGFR42.43105080
10MAP3K102.28469548
11MAP4K11.95313371
12PTK61.94033024
13SMG11.93770002
14TGFBR21.88703982
15EPHB11.86218345
16EEF2K1.84865391
17TYK21.76819139
18MAP3K131.75574286
19MAP2K31.74086502
20LRRK21.73417270
21TNK21.69308305
22TBK11.65825096
23FES1.59186715
24TAOK31.51991387
25RIPK11.50531242
26FLT31.47149678
27MST1R1.37502181
28BLK1.30550767
29STK101.30363281
30TESK21.28223762
31NEK91.27638764
32TIE11.24095335
33KDR1.22638317
34MAP3K11.20573370
35LATS11.16122264
36MARK21.15858840
37GRK61.15700829
38BMX1.15638759
39TAOK21.13283005
40KSR21.12828687
41CDC42BPA1.12756344
42CAMK1D1.11652707
43ZAP701.11410325
44MAP3K71.10686068
45JAK11.08355800
46CSK1.07214346
47SIK31.07080278
48FGR1.05316616
49JAK31.01383966
50MAP3K31.00277945
51SYK0.99311068
52MAPK110.99253038
53PDGFRA0.97608109
54PIK3CG0.97414280
55BTK0.96645469
56MYLK0.95137988
57JAK20.94642822
58CDK60.93393398
59CSF1R0.92576593
60MAP3K140.91119970
61IKBKE0.89615250
62MAP3K60.89517386
63IRAK30.88900862
64PDK10.88815132
65DMPK0.85184237
66KIT0.83801787
67RPS6KA40.82433915
68LYN0.81384366
69HIPK20.80015768
70LCK0.79259777
71CDK40.77119253
72STK30.77056489
73MAPK70.75812171
74PRKAA20.75535075
75EPHA30.73515166
76CDK120.73382054
77PAK40.73182368
78EPHB20.72225985
79NME20.71491776
80MAP3K110.70817347
81FGFR30.70471403
82STK40.70027262
83MTOR0.69589509
84TESK10.69518766
85MET0.68792273
86TRPM70.68523495
87ILK0.68521986
88MATK0.65198624
89PTK20.62990599
90RPS6KA20.62190272
91PRKD10.62104120
92IRAK20.61232181
93CAMK1G0.61002119
94IKBKB0.60833681
95TGFBR10.60809662
96SIK20.60536374
97ITK0.60151966
98MARK30.59849723
99ICK0.59626737
100CHUK0.59030874
101DYRK1B0.58983362
102TXK0.58056283
103STK380.57993629
104HCK0.56851302
105PIM10.55648276
106INSRR0.55072410
107MAP2K20.54437613
108PAK20.53736689
109LMTK20.53170352
110YES10.52852896
111MAP3K20.51928076
112GSK3A0.51524015
113ABL20.50919121
114MAPK120.50538574
115MAPKAPK20.49056171
116PRKG20.48530344
117CAMKK10.48075011
118FYN0.47273764
119MAP3K80.46755953
120TAOK10.46295836
121RPS6KA60.44987151
122MAPKAPK30.44561516
123PDGFRB0.44146365
124IRAK10.43933556
125OBSCN0.42537214
126PRKCH0.42324741
127PRKD20.41251952
128WNK40.41184333
129SGK30.40630350
130MAPK40.40169191
131PDPK10.39985350
132DDR20.39930584
133RPS6KL10.39453545
134RPS6KC10.39453545
135PIK3CA0.39002880
136RET0.37366102
137IRAK40.36509968

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.46202487
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09897171
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04321849
4Nitrogen metabolism_Homo sapiens_hsa009102.92491468
5Fatty acid degradation_Homo sapiens_hsa000712.81632950
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52088458
7Arginine biosynthesis_Homo sapiens_hsa002202.51711819
8Tryptophan metabolism_Homo sapiens_hsa003802.51192280
9Complement and coagulation cascades_Homo sapiens_hsa046102.48797430
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38839957
11Staphylococcus aureus infection_Homo sapiens_hsa051502.30507641
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19871776
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10271135
14Propanoate metabolism_Homo sapiens_hsa006402.09823118
15PPAR signaling pathway_Homo sapiens_hsa033202.07271674
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99562294
17Fatty acid metabolism_Homo sapiens_hsa012121.97133663
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92520833
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88223703
20Caffeine metabolism_Homo sapiens_hsa002321.87708867
21Peroxisome_Homo sapiens_hsa041461.82978771
22Butanoate metabolism_Homo sapiens_hsa006501.73119710
23Graft-versus-host disease_Homo sapiens_hsa053321.70997263
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67372101
25Allograft rejection_Homo sapiens_hsa053301.64688343
26beta-Alanine metabolism_Homo sapiens_hsa004101.61700777
27Histidine metabolism_Homo sapiens_hsa003401.61495751
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60636731
29Autoimmune thyroid disease_Homo sapiens_hsa053201.57258441
30Tuberculosis_Homo sapiens_hsa051521.55700777
31Chemical carcinogenesis_Homo sapiens_hsa052041.54365041
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52222855
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44628159
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43988291
35Selenocompound metabolism_Homo sapiens_hsa004501.41295503
36Non-small cell lung cancer_Homo sapiens_hsa052231.40077080
37Starch and sucrose metabolism_Homo sapiens_hsa005001.38519518
38Carbon metabolism_Homo sapiens_hsa012001.35613271
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35308574
40Primary immunodeficiency_Homo sapiens_hsa053401.34990608
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.31649227
42Chemokine signaling pathway_Homo sapiens_hsa040621.29729431
43T cell receptor signaling pathway_Homo sapiens_hsa046601.29504753
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.28219097
45Phenylalanine metabolism_Homo sapiens_hsa003601.26690592
46Fat digestion and absorption_Homo sapiens_hsa049751.26561106
47Lysine degradation_Homo sapiens_hsa003101.26460510
48Bile secretion_Homo sapiens_hsa049761.25817382
49Pancreatic cancer_Homo sapiens_hsa052121.25714606
50Pyruvate metabolism_Homo sapiens_hsa006201.25151973
51Hematopoietic cell lineage_Homo sapiens_hsa046401.24920851
52Retinol metabolism_Homo sapiens_hsa008301.22454655
53Influenza A_Homo sapiens_hsa051641.21705815
54Platelet activation_Homo sapiens_hsa046111.20792008
55Notch signaling pathway_Homo sapiens_hsa043301.20043595
56VEGF signaling pathway_Homo sapiens_hsa043701.20032264
57TNF signaling pathway_Homo sapiens_hsa046681.18683410
58Antigen processing and presentation_Homo sapiens_hsa046121.18363820
59Sulfur metabolism_Homo sapiens_hsa009201.17439905
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17320192
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17121234
62Sulfur relay system_Homo sapiens_hsa041221.15466604
63ABC transporters_Homo sapiens_hsa020101.13927458
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10030410
65Biosynthesis of amino acids_Homo sapiens_hsa012301.07874423
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06893170
67Hepatitis B_Homo sapiens_hsa051611.02984323
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01434774
69Folate biosynthesis_Homo sapiens_hsa007901.01211598
70Herpes simplex infection_Homo sapiens_hsa051681.00719257
71Tyrosine metabolism_Homo sapiens_hsa003501.00425305
72Fatty acid elongation_Homo sapiens_hsa000621.00273639
73NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00207949
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.99257753
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97778452
76Type I diabetes mellitus_Homo sapiens_hsa049400.97570476
77Renal cell carcinoma_Homo sapiens_hsa052110.96350485
78Phagosome_Homo sapiens_hsa041450.94536848
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.93899234
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92965165
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.87242228
82Apoptosis_Homo sapiens_hsa042100.85710690
83Endometrial cancer_Homo sapiens_hsa052130.85246018
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.84165324
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84149046
86Endocytosis_Homo sapiens_hsa041440.83645343
87Shigellosis_Homo sapiens_hsa051310.83459148
88African trypanosomiasis_Homo sapiens_hsa051430.83202277
89Arginine and proline metabolism_Homo sapiens_hsa003300.82745849
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.81042049
91Insulin resistance_Homo sapiens_hsa049310.78653823
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77888882
93Salmonella infection_Homo sapiens_hsa051320.77488358
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76950417
95Prolactin signaling pathway_Homo sapiens_hsa049170.75640289
96Pentose phosphate pathway_Homo sapiens_hsa000300.75632005
97Choline metabolism in cancer_Homo sapiens_hsa052310.75570467
98Asthma_Homo sapiens_hsa053100.75248536
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73401285
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72151347
101GnRH signaling pathway_Homo sapiens_hsa049120.71911291
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71679925
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71102430
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.70754672
105Glycerolipid metabolism_Homo sapiens_hsa005610.69994599
106Vitamin digestion and absorption_Homo sapiens_hsa049770.69843955
107Insulin signaling pathway_Homo sapiens_hsa049100.69154418
108mTOR signaling pathway_Homo sapiens_hsa041500.68227481
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66891482
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.66413979
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.66317148
112Glutathione metabolism_Homo sapiens_hsa004800.65854220
113HTLV-I infection_Homo sapiens_hsa051660.62150408
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60007823
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.58285484
116Leishmaniasis_Homo sapiens_hsa051400.57599837
117HIF-1 signaling pathway_Homo sapiens_hsa040660.57459841
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.57114202
119Steroid biosynthesis_Homo sapiens_hsa001000.56963339
120Thyroid cancer_Homo sapiens_hsa052160.56550638
121One carbon pool by folate_Homo sapiens_hsa006700.55991454
122FoxO signaling pathway_Homo sapiens_hsa040680.54857780
123Prostate cancer_Homo sapiens_hsa052150.54512033
124Inositol phosphate metabolism_Homo sapiens_hsa005620.51925252
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.51862902
126Viral carcinogenesis_Homo sapiens_hsa052030.51754557
127Colorectal cancer_Homo sapiens_hsa052100.51379243
128Fatty acid biosynthesis_Homo sapiens_hsa000610.50938486
129Renin-angiotensin system_Homo sapiens_hsa046140.49730205
130ErbB signaling pathway_Homo sapiens_hsa040120.46996139
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46769505
132Estrogen signaling pathway_Homo sapiens_hsa049150.46277319
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45575801
134Galactose metabolism_Homo sapiens_hsa000520.44300880
135Amoebiasis_Homo sapiens_hsa051460.40012065
136Pertussis_Homo sapiens_hsa051330.38504319
137Osteoclast differentiation_Homo sapiens_hsa043800.37272838
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37096664
139Malaria_Homo sapiens_hsa051440.34242398
140Legionellosis_Homo sapiens_hsa051340.33721978
141Toxoplasmosis_Homo sapiens_hsa051450.31717424
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.30605649
143Lysosome_Homo sapiens_hsa041420.29879540
144Other glycan degradation_Homo sapiens_hsa005110.29726989
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.29685361
146ECM-receptor interaction_Homo sapiens_hsa045120.27939346
147Acute myeloid leukemia_Homo sapiens_hsa052210.27745080
148Prion diseases_Homo sapiens_hsa050200.27576833
149AMPK signaling pathway_Homo sapiens_hsa041520.27208383
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.23700768
151Small cell lung cancer_Homo sapiens_hsa052220.23362385
152Viral myocarditis_Homo sapiens_hsa054160.23003268
153B cell receptor signaling pathway_Homo sapiens_hsa046620.21785396
154Metabolic pathways_Homo sapiens_hsa011000.20954456
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20669919
156Focal adhesion_Homo sapiens_hsa045100.20612754
157Fructose and mannose metabolism_Homo sapiens_hsa000510.20380271
158Protein digestion and absorption_Homo sapiens_hsa049740.19036382
159Chronic myeloid leukemia_Homo sapiens_hsa052200.18692420
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17771024
161Hepatitis C_Homo sapiens_hsa051600.16684974
162Measles_Homo sapiens_hsa051620.15868102
163Proteoglycans in cancer_Homo sapiens_hsa052050.15273979
164Bladder cancer_Homo sapiens_hsa052190.15059082

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