CTDSPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood coagulation, intrinsic pathway (GO:0007597)5.11459840
2thrombin receptor signaling pathway (GO:0070493)4.36217735
3regulation of integrin-mediated signaling pathway (GO:2001044)4.22726038
4hormone catabolic process (GO:0042447)4.19787736
5COPI coating of Golgi vesicle (GO:0048205)4.00685550
6Golgi transport vesicle coating (GO:0048200)4.00685550
7negative regulation of norepinephrine secretion (GO:0010700)4.00063261
8bundle of His cell to Purkinje myocyte communication (GO:0086069)3.91098025
9mesodermal cell differentiation (GO:0048333)3.76824155
10surfactant homeostasis (GO:0043129)3.76238857
11glomerular basement membrane development (GO:0032836)3.69227792
12platelet degranulation (GO:0002576)3.67368248
13epithelial cell-cell adhesion (GO:0090136)3.66779555
14polyketide metabolic process (GO:0030638)3.61701052
15doxorubicin metabolic process (GO:0044598)3.61701052
16daunorubicin metabolic process (GO:0044597)3.61701052
17protein carboxylation (GO:0018214)3.60937122
18peptidyl-glutamic acid carboxylation (GO:0017187)3.60937122
19aminoglycoside antibiotic metabolic process (GO:0030647)3.53742768
20negative regulation of protein localization to cell surface (GO:2000009)3.52496437
21cell-substrate junction assembly (GO:0007044)3.51091820
22positive regulation of endothelial cell differentiation (GO:0045603)3.49900590
23low-density lipoprotein particle remodeling (GO:0034374)3.42661566
24regulation of lipoprotein metabolic process (GO:0050746)3.42275449
25glomerulus development (GO:0032835)3.30846672
26positive regulation of hemostasis (GO:1900048)3.29824533
27positive regulation of blood coagulation (GO:0030194)3.29824533
28platelet aggregation (GO:0070527)3.24937295
29notochord development (GO:0030903)3.21472561
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20844841
31negative regulation of homotypic cell-cell adhesion (GO:0034111)3.20656379
32hypotonic response (GO:0006971)3.20400050
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19578688
34L-phenylalanine metabolic process (GO:0006558)3.19578688
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.16457460
36metanephric mesenchyme development (GO:0072075)3.15532977
37desmosome organization (GO:0002934)3.15462471
38peptide catabolic process (GO:0043171)3.13422444
39insulin-like growth factor receptor signaling pathway (GO:0048009)3.11894786
40kidney mesenchyme development (GO:0072074)3.10249073
41negative regulation of platelet activation (GO:0010544)3.09342303
42L-phenylalanine catabolic process (GO:0006559)3.08000614
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08000614
44angiogenesis involved in wound healing (GO:0060055)3.04911848
45positive regulation of coagulation (GO:0050820)3.03065966
46positive regulation of histone deacetylation (GO:0031065)3.01911325
47regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00333074
48chemical homeostasis within a tissue (GO:0048875)2.99908420
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.98343199
50keratan sulfate catabolic process (GO:0042340)2.97633688
51lung vasculature development (GO:0060426)2.97587558
52induction of positive chemotaxis (GO:0050930)2.96290040
53establishment of skin barrier (GO:0061436)2.94337463
54type B pancreatic cell development (GO:0003323)2.92111197
55regulation of integrin activation (GO:0033623)2.91551862
56protein retention in ER lumen (GO:0006621)2.91061568
57fibrinolysis (GO:0042730)2.90669122
58nephron epithelium morphogenesis (GO:0072088)2.86536740
59nephron tubule morphogenesis (GO:0072078)2.86536740
60basement membrane organization (GO:0071711)2.86269618
61positive regulation of Rho protein signal transduction (GO:0035025)2.85685898
62regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.84474568
63toxin metabolic process (GO:0009404)2.82531463
64exocrine pancreas development (GO:0031017)2.81798404
65hippo signaling (GO:0035329)2.81696008
66negative regulation of blood coagulation (GO:0030195)2.80962607
67negative regulation of hemostasis (GO:1900047)2.80962607
68mesenchymal cell differentiation involved in renal system development (GO:2001012)2.80842123
69mesenchymal cell differentiation involved in kidney development (GO:0072161)2.80842123
70endothelium development (GO:0003158)2.80527718
71negative regulation of keratinocyte proliferation (GO:0010839)2.78073473
72regulation of water loss via skin (GO:0033561)2.77344126
73regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.76461289
74positive regulation of receptor recycling (GO:0001921)2.75320189
75negative regulation of phagocytosis (GO:0050765)2.75084786
76regulation of early endosome to late endosome transport (GO:2000641)2.75060983
77negative regulation of catenin import into nucleus (GO:0035414)2.73355653
78endocardial cushion development (GO:0003197)2.72868156
79response to dietary excess (GO:0002021)2.71893981
80negative regulation of protein localization to plasma membrane (GO:1903077)2.71454787
81extracellular fibril organization (GO:0043206)2.70997884
82white fat cell differentiation (GO:0050872)2.70718300
83adherens junction assembly (GO:0034333)2.68404854
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.67213739
85cellular response to vitamin (GO:0071295)2.66961156
86negative regulation of coagulation (GO:0050819)2.64507947
87glandular epithelial cell development (GO:0002068)2.63479964
88substrate adhesion-dependent cell spreading (GO:0034446)2.59068913
89glomerular visceral epithelial cell development (GO:0072015)2.58771301
90peptide hormone processing (GO:0016486)2.58216095
91positive regulation of endothelial cell apoptotic process (GO:2000353)2.58098542
92cellular response to vitamin D (GO:0071305)2.57727290
93beta-amyloid metabolic process (GO:0050435)2.56925280
94positive regulation of wound healing (GO:0090303)2.56286314
95dorsal/ventral axis specification (GO:0009950)2.55986395
96renal tubule morphogenesis (GO:0061333)2.55685439
97cell proliferation involved in metanephros development (GO:0072203)2.55625094
98regulation of protein localization to cell surface (GO:2000008)2.54886018
99hemidesmosome assembly (GO:0031581)2.54187826
100regulation of glomerulus development (GO:0090192)2.54051689
101negative regulation of wound healing (GO:0061045)2.53828226
102positive regulation of hormone biosynthetic process (GO:0046886)2.53770972
103positive regulation of systemic arterial blood pressure (GO:0003084)2.52698101
104cell proliferation involved in kidney development (GO:0072111)2.52377302
105cell-substrate adherens junction assembly (GO:0007045)2.52166499
106focal adhesion assembly (GO:0048041)2.52166499
107regulation of platelet aggregation (GO:0090330)2.50252131
108regulation of platelet activation (GO:0010543)2.49991074
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49908726
110lymph vessel development (GO:0001945)2.48291618
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48263411
112gap junction assembly (GO:0016264)2.48123018
113regulation of catenin import into nucleus (GO:0035412)2.47927939
114regulation of cardioblast proliferation (GO:0003264)2.47627844
115regulation of secondary heart field cardioblast proliferation (GO:0003266)2.47627844
116regulation of apoptotic cell clearance (GO:2000425)2.46634342
117cyclooxygenase pathway (GO:0019371)2.46484124
118cell-matrix adhesion (GO:0007160)2.46244987
119regulation of complement activation (GO:0030449)2.45518808
120negative regulation of stem cell proliferation (GO:2000647)2.45316998
121negative regulation of focal adhesion assembly (GO:0051895)2.44583605
122negative regulation of cell junction assembly (GO:1901889)2.44583605
123negative regulation of adherens junction organization (GO:1903392)2.44583605
124regulation of hemostasis (GO:1900046)2.44343184
125regulation of blood coagulation (GO:0030193)2.44343184
126mesenchymal cell differentiation (GO:0048762)2.44165271
127gland morphogenesis (GO:0022612)2.43820798
128positive regulation of adherens junction organization (GO:1903393)2.43483713
129positive regulation of cell junction assembly (GO:1901890)2.42913883
130positive regulation of focal adhesion assembly (GO:0051894)2.42913883
131columnar/cuboidal epithelial cell development (GO:0002066)2.42801452
132cellular response to prostaglandin stimulus (GO:0071379)2.42195295
133multicellular organismal water homeostasis (GO:0050891)2.42010402
134positive regulation of p38MAPK cascade (GO:1900745)2.41518093
135cell differentiation involved in metanephros development (GO:0072202)2.40893788
136negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.40095494
137regulation of endothelial cell differentiation (GO:0045601)2.39877029
138apoptotic cell clearance (GO:0043277)2.39724546
139negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39654682
140regulation of protein activation cascade (GO:2000257)2.39491243
141valine metabolic process (GO:0006573)2.39134237
142negative regulation of chondrocyte differentiation (GO:0032331)2.38673389
143negative regulation of cartilage development (GO:0061037)2.38536265
144regulation of steroid hormone biosynthetic process (GO:0090030)2.38400020
145muscle cell migration (GO:0014812)2.38336138
146bone trabecula formation (GO:0060346)2.38166799
147regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.38165690
148endocardial cushion morphogenesis (GO:0003203)2.38153110
149outer ear morphogenesis (GO:0042473)2.37514159
150protein localization to cell surface (GO:0034394)2.37267529
151receptor recycling (GO:0001881)2.36705309
152cardiac muscle cell proliferation (GO:0060038)2.36479782
153keratinocyte proliferation (GO:0043616)2.36071676
154regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.35649441
155positive regulation of catenin import into nucleus (GO:0035413)2.34859803
156mesenchymal to epithelial transition (GO:0060231)2.33917207
157inner ear receptor cell development (GO:0060119)2.33520972
158cell junction assembly (GO:0034329)2.33520396
159vascular endothelial growth factor signaling pathway (GO:0038084)2.33236712
160negative regulation of epidermis development (GO:0045683)2.33207557
161positive regulation of steroid biosynthetic process (GO:0010893)2.32820070
162platelet activation (GO:0030168)2.31494073
163regulation of positive chemotaxis (GO:0050926)2.31393677
164regulation of norepinephrine secretion (GO:0014061)2.31069149
165positive regulation of positive chemotaxis (GO:0050927)2.30898585
166regulation of coagulation (GO:0050818)2.30633049
167COPII vesicle coating (GO:0048208)2.29994038
168mesonephric tubule development (GO:0072164)2.29653887
169glandular epithelial cell differentiation (GO:0002067)2.29426509
170mesonephric epithelium development (GO:0072163)2.29173818
171positive regulation of chondrocyte differentiation (GO:0032332)2.29004866
172paraxial mesoderm development (GO:0048339)2.28774768
173mammary gland development (GO:0030879)2.28747232
174high-density lipoprotein particle remodeling (GO:0034375)2.28555942
175brown fat cell differentiation (GO:0050873)2.28155838
176negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.28104602
177positive regulation of osteoblast proliferation (GO:0033690)2.27944412
178regulation of protein localization to plasma membrane (GO:1903076)2.26923350
179negative regulation of catecholamine secretion (GO:0033604)2.25824796
180cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.25782399
181glomerular epithelial cell development (GO:0072310)2.24752779
182regulation of Golgi to plasma membrane protein transport (GO:0042996)2.24206026
183collagen fibril organization (GO:0030199)2.23693909
184cell-cell junction assembly (GO:0007043)2.23462831
185mesenchyme morphogenesis (GO:0072132)2.23015972
186regulation of transforming growth factor beta2 production (GO:0032909)2.23007746
187metanephros development (GO:0001656)2.22805004
188mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.22488068
189positive regulation of protein deacetylation (GO:0090312)2.22299966
190positive regulation of glomerulus development (GO:0090193)2.22092157
191activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.21920348
192stress fiber assembly (GO:0043149)2.21648366
193ureteric bud development (GO:0001657)2.21554128
194protein heterotrimerization (GO:0070208)2.21013478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.01617493
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.92717766
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24711049
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20802446
5ZNF263_19887448_ChIP-Seq_K562_Human3.02970009
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.71135487
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.64430156
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55906856
9CLOCK_20551151_ChIP-Seq_293T_Human2.55133831
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40789709
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.40514003
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29405232
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29405232
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29405232
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.28345064
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.19006420
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.18877251
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.17511899
19* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12962268
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11910289
21* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.10842099
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96742068
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.94742515
24AR_21909140_ChIP-Seq_LNCAP_Human1.91911707
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.91127623
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86454344
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86192145
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85056309
29* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82480545
30AHR_22903824_ChIP-Seq_MCF-7_Human1.81138656
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72327682
32* GATA2_21666600_ChIP-Seq_HMVEC_Human1.67532155
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.65885706
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63808018
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.60739494
36* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.60181772
37SOX2_20726797_ChIP-Seq_SW620_Human1.59430038
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59207321
39GATA1_22025678_ChIP-Seq_K562_Human1.58905105
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.57617710
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.56390167
42* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55985441
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55985441
44* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52315065
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51850221
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51674988
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50617721
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50551095
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45884396
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45700511
51GATA1_19941826_ChIP-Seq_K562_Human1.44809650
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44144675
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43994835
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43765221
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.42986039
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42204156
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42204156
58* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39336933
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38788529
60GATA2_19941826_ChIP-Seq_K562_Human1.38727407
61* TCF4_18268006_ChIP-ChIP_LS174T_Human1.38369931
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37885532
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.36144782
64* EED_16625203_ChIP-ChIP_MESCs_Mouse1.35533028
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34408938
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34314996
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33473261
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33437232
69* GATA3_24758297_ChIP-Seq_MCF-7_Human1.31948358
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31907906
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30825509
72* CJUN_26792858_Chip-Seq_BT549_Human1.26501156
73* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26418740
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.26251341
75* KDM2B_26808549_Chip-Seq_K562_Human1.24692444
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24658282
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23724174
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23524203
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23524203
80* GATA6_25053715_ChIP-Seq_YYC3_Human1.23282016
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23246885
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22874420
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22747838
84* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21478941
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20307801
86RXR_22108803_ChIP-Seq_LS180_Human1.19673624
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18310555
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.18193447
89SCL_19346495_ChIP-Seq_HPC-7_Human1.17247696
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16977648
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16059455
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.15343818
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14509837
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13808502
95* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11718071
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.11510295
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11270218
98* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10137878
99* GATA4_25053715_ChIP-Seq_YYC3_Human1.09533291
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09497075
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.09289746
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.09289746
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.08894023
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.08851731
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08343213
106* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08005830
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07395177
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06364677
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06096583
110RACK7_27058665_Chip-Seq_MCF-7_Human1.06072113
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04724305
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04487840
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04106016
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03912522
115* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03815067
116* TP63_23658742_ChIP-Seq_EP156T_Human1.02911987
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.02782557
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02730513
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02621641
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02293726
121TP53_18474530_ChIP-ChIP_U2OS_Human1.01837891
122* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01537315
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01391128
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01186241
125* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01033191
126P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00363201
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99973559
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.99873612
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99829705
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98619440
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95996239
132BRD4_25478319_ChIP-Seq_HGPS_Human0.95509068
133KLF5_25053715_ChIP-Seq_YYC3_Human0.95505069
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95204902
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94987382
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94275100
137GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93941534
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93890435
139TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93747788
140* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93243733
141JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92492751
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91380264
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90890383
144* ATF3_27146783_Chip-Seq_COLON_Human0.90457007
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89662348
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88434330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.16719697
2MP0004264_abnormal_extraembryonic_tissu3.60255386
3MP0008004_abnormal_stomach_pH3.45669752
4MP0004272_abnormal_basement_membrane3.10182645
5MP0002254_reproductive_system_inflammat3.06401578
6MP0002877_abnormal_melanocyte_morpholog2.91887375
7MP0008438_abnormal_cutaneous_collagen2.81915863
8MP0005409_darkened_coat_color2.62334030
9MP0005670_abnormal_white_adipose2.59224687
10MP0000678_abnormal_parathyroid_gland2.58752718
11MP0003705_abnormal_hypodermis_morpholog2.51025891
12MP0010368_abnormal_lymphatic_system2.48354001
13MP0005275_abnormal_skin_tensile2.40913970
14MP0000013_abnormal_adipose_tissue2.39048044
15MP0004043_abnormal_pH_regulation2.34823158
16MP0003122_maternal_imprinting2.23942139
17MP0009780_abnormal_chondrocyte_physiolo2.16021666
18MP0010030_abnormal_orbit_morphology2.00464947
19MP0003283_abnormal_digestive_organ1.98736831
20MP0004084_abnormal_cardiac_muscle1.96927752
21MP0000003_abnormal_adipose_tissue1.95172257
22MP0008961_abnormal_basal_metabolism1.94158164
23MP0000579_abnormal_nail_morphology1.87943630
24MP0009379_abnormal_foot_pigmentation1.85394391
25MP0010234_abnormal_vibrissa_follicle1.81706328
26MP0003123_paternal_imprinting1.81289843
27MP0001879_abnormal_lymphatic_vessel1.79391236
28MP0003950_abnormal_plasma_membrane1.78657022
29MP0005501_abnormal_skin_physiology1.73025966
30MP0005503_abnormal_tendon_morphology1.71057266
31MP0002796_impaired_skin_barrier1.68227637
32MP0001270_distended_abdomen1.68101839
33MP0003942_abnormal_urinary_system1.66283470
34MP0006054_spinal_hemorrhage1.65081915
35MP0005375_adipose_tissue_phenotype1.62221692
36MP0002909_abnormal_adrenal_gland1.59738427
37MP0001958_emphysema1.57955227
38MP0000534_abnormal_ureter_morphology1.56508571
39MP0002060_abnormal_skin_morphology1.56356210
40MP0005666_abnormal_adipose_tissue1.56228034
41MP0004782_abnormal_surfactant_physiolog1.55747279
42MP0005248_abnormal_Harderian_gland1.54411449
43MP0000163_abnormal_cartilage_morphology1.53227213
44MP0005360_urolithiasis1.51609336
45MP0003453_abnormal_keratinocyte_physiol1.50442708
46MP0009250_abnormal_appendicular_skeleto1.49200498
47MP0002837_dystrophic_cardiac_calcinosis1.47920803
48MP0010352_gastrointestinal_tract_polyps1.47212409
49MP0005058_abnormal_lysosome_morphology1.47138302
50MP0008775_abnormal_heart_ventricle1.45847727
51MP0004036_abnormal_muscle_relaxation1.41780924
52MP0003941_abnormal_skin_development1.41176773
53MP0003183_abnormal_peptide_metabolism1.40934994
54MP0003566_abnormal_cell_adhesion1.40552035
55MP0003121_genomic_imprinting1.38371598
56MP0000762_abnormal_tongue_morphology1.37924418
57MP0001661_extended_life_span1.37248977
58MP0005083_abnormal_biliary_tract1.35801605
59MP0005508_abnormal_skeleton_morphology1.32870523
60MP0004185_abnormal_adipocyte_glucose1.32020343
61MP0009384_cardiac_valve_regurgitation1.27337733
62MP0005365_abnormal_bile_salt1.25601721
63MP0002098_abnormal_vibrissa_morphology1.24081421
64MP0003879_abnormal_hair_cell1.22926933
65MP0000428_abnormal_craniofacial_morphol1.21010184
66MP0002108_abnormal_muscle_morphology1.20655809
67MP0000467_abnormal_esophagus_morphology1.20124733
68MP0005257_abnormal_intraocular_pressure1.19601849
69MP0002896_abnormal_bone_mineralization1.18810728
70MP0000566_synostosis1.16488648
71MP0010386_abnormal_urinary_bladder1.15727415
72MP0010329_abnormal_lipoprotein_level1.14970996
73MP0000537_abnormal_urethra_morphology1.14788840
74MP0002089_abnormal_postnatal_growth/wei1.14468228
75MP0001177_atelectasis1.13930772
76MP0003279_aneurysm1.13619813
77MP0003115_abnormal_respiratory_system1.11833784
78MP0004858_abnormal_nervous_system1.09642300
79MP0001944_abnormal_pancreas_morphology1.09055261
80MP0002249_abnormal_larynx_morphology1.07237193
81MP0000049_abnormal_middle_ear1.06797706
82MP0002295_abnormal_pulmonary_circulatio1.06563065
83MP0009053_abnormal_anal_canal1.05935306
84MP0000230_abnormal_systemic_arterial1.05706402
85MP0006138_congestive_heart_failure1.03493071
86MP0005408_hypopigmentation1.03444718
87MP0002128_abnormal_blood_circulation1.02380904
88MP0002115_abnormal_skeleton_extremities1.01518147
89MP0001756_abnormal_urination0.97311323
90MP0000465_gastrointestinal_hemorrhage0.96047518
91MP0001915_intracranial_hemorrhage0.95643814
92MP0003935_abnormal_craniofacial_develop0.94620955
93MP0005379_endocrine/exocrine_gland_phen0.94442541
94MP0010771_integument_phenotype0.93633737
95MP0003091_abnormal_cell_migration0.93586318
96MP0000767_abnormal_smooth_muscle0.93061987
97MP0004130_abnormal_muscle_cell0.92670135
98MP0001346_abnormal_lacrimal_gland0.91964338
99MP0002233_abnormal_nose_morphology0.91812849
100MP0005023_abnormal_wound_healing0.91092185
101MP0005623_abnormal_meninges_morphology0.90497608
102MP0003638_abnormal_response/metabolism_0.90399491
103MP0001851_eye_inflammation0.90347456
104MP0001216_abnormal_epidermal_layer0.90278766
105MP0000516_abnormal_urinary_system0.89060563
106MP0005367_renal/urinary_system_phenotyp0.89060563
107MP0003890_abnormal_embryonic-extraembry0.86828221
108MP0001849_ear_inflammation0.86253970
109MP0005167_abnormal_blood-brain_barrier0.86200466
110MP0005165_increased_susceptibility_to0.85256475
111MP0001765_abnormal_ion_homeostasis0.85154111
112MP0002116_abnormal_craniofacial_bone0.83956770
113MP0005388_respiratory_system_phenotype0.83650790
114MP0002133_abnormal_respiratory_system0.83650790
115MP0003755_abnormal_palate_morphology0.83315828
116MP0005394_taste/olfaction_phenotype0.83225508
117MP0005499_abnormal_olfactory_system0.83225508
118MP0003787_abnormal_imprinting0.82776845
119MP0003385_abnormal_body_wall0.82382401
120MP0010630_abnormal_cardiac_muscle0.82239680
121MP0002109_abnormal_limb_morphology0.82007214
122MP0001666_abnormal_nutrient_absorption0.81848850
123MP0000377_abnormal_hair_follicle0.81633204
124MP0003300_gastrointestinal_ulcer0.80857446
125MP0005085_abnormal_gallbladder_physiolo0.80650064
126MP0001664_abnormal_digestion0.80484160
127MP0000383_abnormal_hair_follicle0.80076323
128MP0002972_abnormal_cardiac_muscle0.78976711
129MP0009697_abnormal_copulation0.78792205
130MP0009643_abnormal_urine_homeostasis0.78152405
131MP0003045_fibrosis0.78143748
132MP0003718_maternal_effect0.77600009
133MP0001544_abnormal_cardiovascular_syste0.77244841
134MP0005385_cardiovascular_system_phenoty0.77244841
135MP0002925_abnormal_cardiovascular_devel0.77099522
136MP0010678_abnormal_skin_adnexa0.77006870
137MP0002234_abnormal_pharynx_morphology0.76782799
138MP0004233_abnormal_muscle_weight0.75687090
139MP0005220_abnormal_exocrine_pancreas0.75683758
140MP0002932_abnormal_joint_morphology0.75503407
141MP0001299_abnormal_eye_distance/0.75162527
142MP0005164_abnormal_response_to0.74440520
143MP0009115_abnormal_fat_cell0.73087668
144MP0005620_abnormal_muscle_contractility0.72676017
145MP0002086_abnormal_extraembryonic_tissu0.71922206
146MP0002876_abnormal_thyroid_physiology0.71836696
147MP0000432_abnormal_head_morphology0.71189272
148MP0003828_pulmonary_edema0.71108942
149MP0001614_abnormal_blood_vessel0.69999843
150MP0004883_abnormal_blood_vessel0.69790167
151MP0004087_abnormal_muscle_fiber0.69325360
152MP0000462_abnormal_digestive_system0.64443805

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.10781258
2Increased mean platelet volume (HP:0011877)6.76948485
3Abnormal platelet volume (HP:0011876)5.92581501
4Prolonged bleeding time (HP:0003010)5.90441073
5Purpura (HP:0000979)5.06575632
6Hepatoblastoma (HP:0002884)4.27943969
7Petechiae (HP:0000967)4.16389823
8Gingival bleeding (HP:0000225)3.84633549
9Hyperactive renin-angiotensin system (HP:0000841)3.70108835
10Epistaxis (HP:0000421)3.54679222
11Impaired platelet aggregation (HP:0003540)3.29695827
12Abnormal platelet function (HP:0011869)3.29695827
13Abnormality of the common coagulation pathway (HP:0010990)3.20222921
14Broad metatarsal (HP:0001783)2.98444949
15Deep venous thrombosis (HP:0002625)2.90239960
16Bilateral microphthalmos (HP:0007633)2.87444085
17Acanthocytosis (HP:0001927)2.82539543
18Hyperinsulinemic hypoglycemia (HP:0000825)2.81568258
19Right ventricular cardiomyopathy (HP:0011663)2.76009224
20Abnormality of chloride homeostasis (HP:0011422)2.71604725
21Abnormal pancreas size (HP:0012094)2.70020055
22Hyperlipoproteinemia (HP:0010980)2.64404355
23Cervical subluxation (HP:0003308)2.58768155
24Abnormality of carpal bone ossification (HP:0006257)2.53384719
25Flat acetabular roof (HP:0003180)2.51978577
26Flat capital femoral epiphysis (HP:0003370)2.51451727
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.49091362
28Pancreatic islet-cell hyperplasia (HP:0004510)2.47149354
29Cardiovascular calcification (HP:0011915)2.41809268
30Vascular calcification (HP:0004934)2.41093572
31Hyperkalemia (HP:0002153)2.40416921
32Xanthomatosis (HP:0000991)2.39657930
33Abnormality of renin-angiotensin system (HP:0000847)2.30424127
34Partial duplication of thumb phalanx (HP:0009944)2.28932976
35Joint hemorrhage (HP:0005261)2.28694654
36Acanthosis nigricans (HP:0000956)2.27460426
37Abnormality of the distal phalanges of the toes (HP:0010182)2.26303442
38Nasolacrimal duct obstruction (HP:0000579)2.25476885
39Fragile skin (HP:0001030)2.24842977
40Poikilocytosis (HP:0004447)2.20623372
41Lymphangioma (HP:0100764)2.18391724
42Hypoplastic labia majora (HP:0000059)2.17304561
43Hypokalemia (HP:0002900)2.16950503
44Metaphyseal cupping (HP:0003021)2.16718200
45Abnormality of potassium homeostasis (HP:0011042)2.16364589
46Pterygium (HP:0001059)2.15838919
47Partial duplication of the phalanx of hand (HP:0009999)2.15796948
48Thin bony cortex (HP:0002753)2.15586969
49Mitral stenosis (HP:0001718)2.15571053
50Hyperaldosteronism (HP:0000859)2.13582791
51Mildly elevated creatine phosphokinase (HP:0008180)2.12188513
52Hypokalemic alkalosis (HP:0001949)2.09488367
53Decreased circulating renin level (HP:0003351)2.08702336
54Bundle branch block (HP:0011710)2.07805210
55Bronchomalacia (HP:0002780)2.07197988
56Protrusio acetabuli (HP:0003179)2.06621377
57Premature rupture of membranes (HP:0001788)2.05946370
58Bifid tongue (HP:0010297)2.05893855
59Bruising susceptibility (HP:0000978)2.05669406
60Shallow orbits (HP:0000586)2.04713569
61Abnormality of the lacrimal duct (HP:0011481)2.03931535
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03799004
63Abnormality of the acetabulum (HP:0003170)2.03740725
64Generalized aminoaciduria (HP:0002909)2.03726486
65Abnormal ossification of hand bones (HP:0005921)2.03277653
66Abnormality of the Achilles tendon (HP:0005109)2.02148050
67Arterial tortuosity (HP:0005116)2.01123338
68Advanced eruption of teeth (HP:0006288)2.00616952
69Insulin-resistant diabetes mellitus (HP:0000831)2.00496942
70Abnormal auditory evoked potentials (HP:0006958)2.00441296
71Ankle contracture (HP:0006466)2.00419662
72Aortic aneurysm (HP:0004942)2.00117049
73Neonatal death (HP:0003811)1.99171991
74Aplasia involving bones of the upper limbs (HP:0009823)1.98996848
75Aplasia of the phalanges of the hand (HP:0009802)1.98996848
76Aplasia involving bones of the extremities (HP:0009825)1.98996848
77Spinal rigidity (HP:0003306)1.98637506
78Mesangial abnormality (HP:0001966)1.98413608
79Renal salt wasting (HP:0000127)1.96833921
80Papillary thyroid carcinoma (HP:0002895)1.95682319
81Shawl scrotum (HP:0000049)1.94809500
82Increased connective tissue (HP:0009025)1.94500223
83Focal segmental glomerulosclerosis (HP:0000097)1.94361526
84Hypercholesterolemia (HP:0003124)1.93995090
85Distal lower limb amyotrophy (HP:0008944)1.93074066
86Bone cyst (HP:0012062)1.91816563
87Nephroblastoma (Wilms tumor) (HP:0002667)1.90942042
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.90098813
89Conjunctival telangiectasia (HP:0000524)1.89978202
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89965667
91Hypophosphatemic rickets (HP:0004912)1.89741342
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88685429
93Abnormal delivery (HP:0001787)1.88636586
94Visceral angiomatosis (HP:0100761)1.86686516
95Embryonal renal neoplasm (HP:0011794)1.86508659
96Macroorchidism (HP:0000053)1.86419996
97Growth hormone excess (HP:0000845)1.86378275
98Mesomelia (HP:0003027)1.86161126
99Delayed epiphyseal ossification (HP:0002663)1.85799691
100Asymmetry of the thorax (HP:0001555)1.85000553
101Atrophic scars (HP:0001075)1.84591491
102Epiphyseal dysplasia (HP:0002656)1.83564186
103Abnormality of endocrine pancreas physiology (HP:0012093)1.83342933
104Abnormality of the pancreatic islet cells (HP:0006476)1.83342933
105Abnormality of the labia majora (HP:0012881)1.83059189
106Abnormality of the nasolacrimal system (HP:0000614)1.82487810
107Accelerated skeletal maturation (HP:0005616)1.82151308
108Ankyloglossia (HP:0010296)1.81538825
109Abnormal cartilage morphology (HP:0002763)1.80691263
110Glomerulosclerosis (HP:0000096)1.80234798
111Back pain (HP:0003418)1.79134955
112Abnormality of skeletal muscle fiber size (HP:0012084)1.78604208
113Enlarged epiphyses (HP:0010580)1.77987309
114Hemangiomatosis (HP:0007461)1.77551023
115Turricephaly (HP:0000262)1.77201698
116Pili torti (HP:0003777)1.76635336
117Complement deficiency (HP:0004431)1.75651753
118Neonatal short-limb short stature (HP:0008921)1.75012364
119Germ cell neoplasia (HP:0100728)1.74657179
120Dyschromatopsia (HP:0007641)1.74590820
121Gout (HP:0001997)1.74563889
122Distal lower limb muscle weakness (HP:0009053)1.74015077
123Abnormal pupillary function (HP:0007686)1.73783919
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73691551
125Fragile nails (HP:0001808)1.73493782
126Renal duplication (HP:0000075)1.73239381
127Buphthalmos (HP:0000557)1.72978777
128Vascular tortuosity (HP:0004948)1.72881251
129Metabolic alkalosis (HP:0200114)1.72470767
130Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72251378
131Popliteal pterygium (HP:0009756)1.71856654
132Oligomenorrhea (HP:0000876)1.70670810
133Skin pits (HP:0100276)1.69207680
134Aneurysm (HP:0002617)1.68926270
135Renal tubular acidosis (HP:0001947)1.68410226
136Spontaneous abortion (HP:0005268)1.67928961
137Exostoses (HP:0100777)1.67884827
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67809172
139Broad palm (HP:0001169)1.67335590
140Coxa vara (HP:0002812)1.67148034
141Abnormal hand bone ossification (HP:0010660)1.66995105
142Broad thumb (HP:0011304)1.66633167
143Preaxial foot polydactyly (HP:0001841)1.65730309
144Type 1 muscle fiber predominance (HP:0003803)1.65706760
145Abnormality of complement system (HP:0005339)1.65676584
146Hyperglycemia (HP:0003074)1.65111401
147Broad face (HP:0000283)1.65003067
148Cerebral aneurysm (HP:0004944)1.63791002
149Ventricular tachycardia (HP:0004756)1.63632426
150Neoplasm of the heart (HP:0100544)1.63571300
151Osteoarthritis (HP:0002758)1.63508859
152Abnormality of the frontal sinuses (HP:0002687)1.63493565
153Rickets (HP:0002748)1.63222776
154Osteolytic defects of the hand bones (HP:0009699)1.63100558
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.63100558
156Laryngomalacia (HP:0001601)1.63000301
157Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62843419
158Uterine leiomyosarcoma (HP:0002891)1.62581091
159Leiomyosarcoma (HP:0100243)1.62581091
160Preauricular pit (HP:0004467)1.62094907
161Periauricular skin pits (HP:0100277)1.62094907
162Increased variability in muscle fiber diameter (HP:0003557)1.61975217
163Abnormality of the intrinsic pathway (HP:0010989)1.61728312
164Milia (HP:0001056)1.59767384
165Aortic dissection (HP:0002647)1.59481402
166Abnormal tarsal ossification (HP:0008369)1.58692964
167Exercise-induced myalgia (HP:0003738)1.57119001
168Hemorrhage of the eye (HP:0011885)1.56509620
169Conjugated hyperbilirubinemia (HP:0002908)1.56506169
170Myocardial infarction (HP:0001658)1.54219676
171Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.54062612
172Bladder diverticulum (HP:0000015)1.53549483
173Wormian bones (HP:0002645)1.52413231
174Alopecia of scalp (HP:0002293)1.52000798
175Prolonged partial thromboplastin time (HP:0003645)1.51917969
176Hyperthyroidism (HP:0000836)1.51414298
177Intrahepatic cholestasis (HP:0001406)1.50871564
178Upper limb muscle weakness (HP:0003484)1.50298954
179Thin skin (HP:0000963)1.50052717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.89394191
2ERN13.69543041
3EIF2AK12.99567870
4EPHA22.73217187
5MAP3K22.70280362
6TGFBR22.64889110
7LATS12.56510855
8PRKD32.55164462
9RIPK12.36360452
10TRIB32.34715004
11FGFR22.30794025
12WNK42.25701863
13CDK122.25653911
14STK242.17344650
15INSRR2.08248788
16GRK52.01988913
17EEF2K1.99341328
18CAMK1D1.99283949
19TIE11.91410455
20AKT31.87393947
21ARAF1.83211427
22MST41.81386507
23MAPKAPK31.75772459
24PDGFRA1.70139543
25HIPK21.68490555
26EPHB21.66796836
27MAP3K31.65540224
28WNK11.61754468
29LMTK21.58485313
30SIK11.47787755
31CAMK1G1.46976909
32FGFR41.45939812
33FGFR31.43481778
34FER1.41360985
35TTN1.41348209
36PRKG21.40537747
37GRK11.39221564
38PAK41.37510673
39DDR21.35490439
40STK38L1.35479296
41WNK31.32103286
42MST1R1.31091171
43MYLK1.29911192
44PASK1.25691880
45PAK21.22982937
46MAPK71.18451525
47MAP3K61.14090192
48PTK21.14014249
49PIM21.13392676
50CAMK41.12717712
51MAPK151.07706658
52PAK31.05722821
53MARK21.05079837
54MAP2K21.04684662
55PTK61.03996316
56MAP3K71.02597492
57ICK1.00419595
58STK31.00214543
59TRPM70.99436348
60OXSR10.98470341
61ADRBK20.96513036
62MAP3K10.94723560
63PKN20.94642192
64NTRK10.92252840
65SGK20.88419722
66MET0.85634756
67TGFBR10.84725629
68RPS6KA20.82840827
69PHKG20.79550647
70PHKG10.79550647
71PRKCH0.77556232
72PRKD20.72957031
73ABL20.72003736
74IRAK30.71858082
75PDGFRB0.71138201
76SGK2230.70575625
77SGK4940.70575625
78ADRBK10.70135363
79DAPK30.67012728
80CDK60.66769545
81ERBB20.66682863
82SMG10.66603217
83PBK0.65131123
84TEC0.64980857
85EPHA30.64772247
86DMPK0.63601842
87SGK30.62847711
88MAP2K10.62022174
89ILK0.61632524
90BRSK20.61495631
91NEK90.58961213
92LATS20.58809895
93CDK90.58210659
94CSF1R0.58133540
95IGF1R0.57691555
96CDC42BPA0.56775161
97TYRO30.53819369
98PAK10.52314846
99CDK80.52162922
100FGFR10.52124565
101NTRK30.51971482
102RPS6KB20.51440340
103PIK3CA0.51395644
104TESK10.50704687
105BRAF0.50463699
106BMX0.49811316
107NUAK10.49806106
108GRK60.48935246
109MTOR0.48397351
110GSK3A0.46909622
111STK380.46871145
112PRKAA20.45632894
113PRKCE0.45368250
114PRKD10.45167785
115CAMK10.45142352
116ZAP700.44751521
117MATK0.43911957
118PIK3CG0.43562765
119OBSCN0.42664926
120PRPF4B0.41934930
121EPHA40.41599012
122BCKDK0.41208081
123RET0.40219339
124TAOK10.40212351
125MUSK0.39986304
126STK40.39069038
127CSNK1E0.38906677
128CAMK2G0.38348107
129PTK2B0.37936666
130ROCK10.36658686
131PNCK0.36585141
132MOS0.36465005
133STK390.36417165
134DYRK1B0.36310012
135NEK20.35774470
136PRKCI0.35731200
137CDK30.34147835
138KSR20.33860795
139CASK0.33693921
140PDPK10.33387685
141TAOK30.32771911

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.94998139
2Platelet activation_Homo sapiens_hsa046112.52417562
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.23038665
4Protein digestion and absorption_Homo sapiens_hsa049742.21727868
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17598529
6ECM-receptor interaction_Homo sapiens_hsa045122.16658542
7Complement and coagulation cascades_Homo sapiens_hsa046101.92838345
8Sulfur metabolism_Homo sapiens_hsa009201.87224285
9Fatty acid biosynthesis_Homo sapiens_hsa000611.78653628
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.68744184
11Focal adhesion_Homo sapiens_hsa045101.59107293
12Renin secretion_Homo sapiens_hsa049241.47190503
13Arachidonic acid metabolism_Homo sapiens_hsa005901.46547460
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45460186
15Protein export_Homo sapiens_hsa030601.45328431
16Arginine and proline metabolism_Homo sapiens_hsa003301.45320916
17Insulin secretion_Homo sapiens_hsa049111.44097292
18Thyroid cancer_Homo sapiens_hsa052161.39030159
19Arginine biosynthesis_Homo sapiens_hsa002201.38047498
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37946181
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35609636
22Galactose metabolism_Homo sapiens_hsa000521.34418725
23Gap junction_Homo sapiens_hsa045401.31186522
24Fatty acid degradation_Homo sapiens_hsa000711.30881513
25Adherens junction_Homo sapiens_hsa045201.29717233
26Fat digestion and absorption_Homo sapiens_hsa049751.29435714
27Fatty acid elongation_Homo sapiens_hsa000621.26796591
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25638972
29Histidine metabolism_Homo sapiens_hsa003401.22137888
30Hedgehog signaling pathway_Homo sapiens_hsa043401.20655940
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18392646
32Tyrosine metabolism_Homo sapiens_hsa003501.18075190
33Basal cell carcinoma_Homo sapiens_hsa052171.17947933
34Bile secretion_Homo sapiens_hsa049761.16985968
35Proteoglycans in cancer_Homo sapiens_hsa052051.14351460
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12788950
37Insulin resistance_Homo sapiens_hsa049311.11885231
38Thyroid hormone synthesis_Homo sapiens_hsa049181.09192823
39Glycerolipid metabolism_Homo sapiens_hsa005611.08730230
40Fatty acid metabolism_Homo sapiens_hsa012121.07994746
41Hippo signaling pathway_Homo sapiens_hsa043901.07166501
42Ovarian steroidogenesis_Homo sapiens_hsa049131.06804848
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05293086
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05168448
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.04614365
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03676550
47cAMP signaling pathway_Homo sapiens_hsa040241.02592809
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02363166
49Prostate cancer_Homo sapiens_hsa052151.02191201
50TGF-beta signaling pathway_Homo sapiens_hsa043501.01593332
51Fructose and mannose metabolism_Homo sapiens_hsa000511.01420431
52PPAR signaling pathway_Homo sapiens_hsa033201.00813869
53Phenylalanine metabolism_Homo sapiens_hsa003600.96660090
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95583875
55Starch and sucrose metabolism_Homo sapiens_hsa005000.94990016
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94308921
57Bladder cancer_Homo sapiens_hsa052190.94217984
58Tight junction_Homo sapiens_hsa045300.94114753
59Melanogenesis_Homo sapiens_hsa049160.93958858
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93401700
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93018905
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92641888
63Melanoma_Homo sapiens_hsa052180.90898260
64mTOR signaling pathway_Homo sapiens_hsa041500.90060049
65Dilated cardiomyopathy_Homo sapiens_hsa054140.89903797
66Glutathione metabolism_Homo sapiens_hsa004800.89844525
67Circadian rhythm_Homo sapiens_hsa047100.89160632
68Rap1 signaling pathway_Homo sapiens_hsa040150.88346974
69Type II diabetes mellitus_Homo sapiens_hsa049300.88286494
70Nitrogen metabolism_Homo sapiens_hsa009100.87923493
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87673880
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87452085
73Endometrial cancer_Homo sapiens_hsa052130.87134479
74Insulin signaling pathway_Homo sapiens_hsa049100.85782496
75Other glycan degradation_Homo sapiens_hsa005110.85758605
76Glioma_Homo sapiens_hsa052140.84910535
77Vibrio cholerae infection_Homo sapiens_hsa051100.84383338
78Renin-angiotensin system_Homo sapiens_hsa046140.83800904
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83564522
80Cocaine addiction_Homo sapiens_hsa050300.83077240
81Pyruvate metabolism_Homo sapiens_hsa006200.82931929
82beta-Alanine metabolism_Homo sapiens_hsa004100.82657369
83AMPK signaling pathway_Homo sapiens_hsa041520.81798094
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81164330
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80714457
86Mineral absorption_Homo sapiens_hsa049780.80041350
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79794496
88N-Glycan biosynthesis_Homo sapiens_hsa005100.78814923
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.78723646
90Small cell lung cancer_Homo sapiens_hsa052220.78576664
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77965978
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77939650
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74735008
94Glucagon signaling pathway_Homo sapiens_hsa049220.74031539
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73886645
96Pancreatic secretion_Homo sapiens_hsa049720.73774416
97Pathways in cancer_Homo sapiens_hsa052000.73754130
98Steroid biosynthesis_Homo sapiens_hsa001000.73574262
99Wnt signaling pathway_Homo sapiens_hsa043100.73394393
100Amoebiasis_Homo sapiens_hsa051460.72851323
101Pentose phosphate pathway_Homo sapiens_hsa000300.72791554
102Amphetamine addiction_Homo sapiens_hsa050310.72533065
103Dorso-ventral axis formation_Homo sapiens_hsa043200.71727643
104Linoleic acid metabolism_Homo sapiens_hsa005910.70792613
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70075721
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69027008
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68456872
108Lysosome_Homo sapiens_hsa041420.68242360
109Retinol metabolism_Homo sapiens_hsa008300.67538305
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.66742508
111Propanoate metabolism_Homo sapiens_hsa006400.65882686
112Non-small cell lung cancer_Homo sapiens_hsa052230.65720830
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.65035206
114Endocytosis_Homo sapiens_hsa041440.64765596
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64615119
116Choline metabolism in cancer_Homo sapiens_hsa052310.64345291
117Long-term potentiation_Homo sapiens_hsa047200.62902187
118Sphingolipid metabolism_Homo sapiens_hsa006000.62071300
119Notch signaling pathway_Homo sapiens_hsa043300.61771629
120Long-term depression_Homo sapiens_hsa047300.61704406
121Estrogen signaling pathway_Homo sapiens_hsa049150.61596185
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.61333478
123Circadian entrainment_Homo sapiens_hsa047130.61149901
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60951665
125Pancreatic cancer_Homo sapiens_hsa052120.60738057
126Gastric acid secretion_Homo sapiens_hsa049710.60611772
127Salivary secretion_Homo sapiens_hsa049700.58974263
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.58888043
129Ras signaling pathway_Homo sapiens_hsa040140.58313421
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57524717
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.57474983
132Taste transduction_Homo sapiens_hsa047420.57204874
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.56940966
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56101066
135Chemical carcinogenesis_Homo sapiens_hsa052040.55645818
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54386216
137ABC transporters_Homo sapiens_hsa020100.53519645
138Inositol phosphate metabolism_Homo sapiens_hsa005620.52779728
139Chronic myeloid leukemia_Homo sapiens_hsa052200.51877526
140Serotonergic synapse_Homo sapiens_hsa047260.50976541
141VEGF signaling pathway_Homo sapiens_hsa043700.44698713

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