

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 4.75316463 |
| 2 | nuclear pore organization (GO:0006999) | 4.63740505 |
| 3 | mitotic sister chromatid cohesion (GO:0007064) | 4.49139659 |
| 4 | kinetochore organization (GO:0051383) | 4.37705884 |
| 5 | mitotic metaphase plate congression (GO:0007080) | 4.23924704 |
| 6 | mitotic chromosome condensation (GO:0007076) | 4.08120550 |
| 7 | chromatin remodeling at centromere (GO:0031055) | 4.04074047 |
| 8 | CENP-A containing nucleosome assembly (GO:0034080) | 4.03966645 |
| 9 | meiotic chromosome segregation (GO:0045132) | 3.98424862 |
| 10 | DNA synthesis involved in DNA repair (GO:0000731) | 3.95991259 |
| 11 | DNA replication checkpoint (GO:0000076) | 3.95257912 |
| 12 | protein localization to kinetochore (GO:0034501) | 3.94015806 |
| 13 | mitotic recombination (GO:0006312) | 3.93624773 |
| 14 | DNA replication initiation (GO:0006270) | 3.89204304 |
| 15 | regulation of DNA endoreduplication (GO:0032875) | 3.88939868 |
| 16 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.88813195 |
| 17 | non-recombinational repair (GO:0000726) | 3.88792811 |
| 18 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.88792811 |
| 19 | metaphase plate congression (GO:0051310) | 3.87367021 |
| 20 | telomere maintenance via recombination (GO:0000722) | 3.83238572 |
| 21 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.81582644 |
| 22 | DNA replication-independent nucleosome organization (GO:0034724) | 3.81582644 |
| 23 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.78154486 |
| 24 | DNA unwinding involved in DNA replication (GO:0006268) | 3.75102087 |
| 25 | sister chromatid segregation (GO:0000819) | 3.74951292 |
| 26 | kinetochore assembly (GO:0051382) | 3.72928575 |
| 27 | protein K6-linked ubiquitination (GO:0085020) | 3.70428355 |
| 28 | pore complex assembly (GO:0046931) | 3.70335824 |
| 29 | DNA strand elongation (GO:0022616) | 3.66962867 |
| 30 | mitotic sister chromatid segregation (GO:0000070) | 3.65083316 |
| 31 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.64388776 |
| 32 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.58080724 |
| 33 | negative regulation of DNA recombination (GO:0045910) | 3.54614244 |
| 34 | establishment of chromosome localization (GO:0051303) | 3.52427400 |
| 35 | V(D)J recombination (GO:0033151) | 3.50929156 |
| 36 | histone exchange (GO:0043486) | 3.48021340 |
| 37 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.47108452 |
| 38 | mitotic nuclear envelope disassembly (GO:0007077) | 3.43579946 |
| 39 | regulation of centriole replication (GO:0046599) | 3.43184964 |
| 40 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.42062847 |
| 41 | protein localization to chromosome, centromeric region (GO:0071459) | 3.40531062 |
| 42 | DNA topological change (GO:0006265) | 3.40160598 |
| 43 | regulation of spindle organization (GO:0090224) | 3.37926564 |
| 44 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.37689104 |
| 45 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.37689104 |
| 46 | purine nucleobase biosynthetic process (GO:0009113) | 3.35963995 |
| 47 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.35687394 |
| 48 | spindle checkpoint (GO:0031577) | 3.34476859 |
| 49 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.34397571 |
| 50 | telomere maintenance via telomere lengthening (GO:0010833) | 3.34334142 |
| 51 | sister chromatid cohesion (GO:0007062) | 3.33968110 |
| 52 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.31377771 |
| 53 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.31377771 |
| 54 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.31377771 |
| 55 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.29606347 |
| 56 | centriole replication (GO:0007099) | 3.29103882 |
| 57 | intra-S DNA damage checkpoint (GO:0031573) | 3.28604790 |
| 58 | mismatch repair (GO:0006298) | 3.28417430 |
| 59 | replication fork processing (GO:0031297) | 3.26976271 |
| 60 | nucleobase biosynthetic process (GO:0046112) | 3.24158812 |
| 61 | DNA double-strand break processing (GO:0000729) | 3.22908574 |
| 62 | microtubule depolymerization (GO:0007019) | 3.22091296 |
| 63 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.21320681 |
| 64 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.21320681 |
| 65 | translesion synthesis (GO:0019985) | 3.19139293 |
| 66 | nuclear envelope disassembly (GO:0051081) | 3.19012438 |
| 67 | membrane disassembly (GO:0030397) | 3.19012438 |
| 68 | spindle assembly checkpoint (GO:0071173) | 3.17780914 |
| 69 | regulation of sister chromatid cohesion (GO:0007063) | 3.15679269 |
| 70 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.14702812 |
| 71 | telomere maintenance (GO:0000723) | 3.14655013 |
| 72 | IMP biosynthetic process (GO:0006188) | 3.14406813 |
| 73 | chromosome segregation (GO:0007059) | 3.14251809 |
| 74 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.10367020 |
| 75 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.10367020 |
| 76 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.10367020 |
| 77 | negative regulation of sister chromatid segregation (GO:0033046) | 3.10367020 |
| 78 | postreplication repair (GO:0006301) | 3.10126466 |
| 79 | telomere organization (GO:0032200) | 3.09714361 |
| 80 | DNA geometric change (GO:0032392) | 3.09612909 |
| 81 | establishment of integrated proviral latency (GO:0075713) | 3.09233924 |
| 82 | negative regulation of chromosome segregation (GO:0051985) | 3.09068928 |
| 83 | mitotic spindle checkpoint (GO:0071174) | 3.09023158 |
| 84 | DNA duplex unwinding (GO:0032508) | 3.08428749 |
| 85 | microtubule anchoring (GO:0034453) | 3.08387492 |
| 86 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.07988986 |
| 87 | mitotic spindle assembly checkpoint (GO:0007094) | 3.07712606 |
| 88 | regulation of chromosome segregation (GO:0051983) | 3.06098231 |
| 89 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 3.05819643 |
| 90 | somatic cell DNA recombination (GO:0016444) | 3.05819643 |
| 91 | regulation of centrosome cycle (GO:0046605) | 3.03189972 |
| 92 | regulation of sister chromatid segregation (GO:0033045) | 3.03041717 |
| 93 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.03041717 |
| 94 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.03041717 |
| 95 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.01806064 |
| 96 | ATP-dependent chromatin remodeling (GO:0043044) | 3.01742091 |
| 97 | mitotic G2/M transition checkpoint (GO:0044818) | 3.00962733 |
| 98 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.00949998 |
| 99 | chromatin assembly or disassembly (GO:0006333) | 3.00557954 |
| 100 | regulation of centrosome duplication (GO:0010824) | 3.00443290 |
| 101 | neural tube formation (GO:0001841) | 2.97075834 |
| 102 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.96812600 |
| 103 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.96812600 |
| 104 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.96812600 |
| 105 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.96101090 |
| 106 | dosage compensation (GO:0007549) | 2.92048772 |
| 107 | regulation of histone H3-K9 methylation (GO:0051570) | 2.91899068 |
| 108 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.91023116 |
| 109 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.91023116 |
| 110 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.88186004 |
| 111 | DNA conformation change (GO:0071103) | 2.88085260 |
| 112 | somatic diversification of immune receptors (GO:0002200) | 2.87822905 |
| 113 | resolution of meiotic recombination intermediates (GO:0000712) | 2.87154313 |
| 114 | protein localization to chromosome (GO:0034502) | 2.86626397 |
| 115 | pre-miRNA processing (GO:0031054) | 2.84455988 |
| 116 | positive regulation of chromosome segregation (GO:0051984) | 2.84009910 |
| 117 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.83729385 |
| 118 | negative regulation of DNA repair (GO:0045738) | 2.82759854 |
| 119 | regulation of mitotic spindle organization (GO:0060236) | 2.81192444 |
| 120 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.77646175 |
| 121 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.77180678 |
| 122 | DNA ligation (GO:0006266) | 2.75340041 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.12048096 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.74995938 |
| 3 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.53884633 |
| 4 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.16325044 |
| 5 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.00372532 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.65700991 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.65110863 |
| 8 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.64332550 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.54849057 |
| 10 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.51523705 |
| 11 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.48231597 |
| 12 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.25823506 |
| 13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.20242695 |
| 14 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.19554034 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.18733336 |
| 16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.12548768 |
| 17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.05424581 |
| 18 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.05310751 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.03922170 |
| 20 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.03079293 |
| 21 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.00049791 |
| 22 | E2F7_22180533_ChIP-Seq_HELA_Human | 11.5019857 |
| 23 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.98408671 |
| 24 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.95673443 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.95481529 |
| 26 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.88273342 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.85952606 |
| 28 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84463071 |
| 29 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.83589412 |
| 30 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.79710666 |
| 31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.75604120 |
| 32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.73848369 |
| 33 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.64507605 |
| 34 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.62621896 |
| 35 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.62454152 |
| 36 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.62191247 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.58887673 |
| 38 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.57828922 |
| 39 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.57636960 |
| 40 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.57131625 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56934139 |
| 42 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.53008161 |
| 43 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.52511663 |
| 44 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.49522234 |
| 45 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.48607987 |
| 46 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.46474231 |
| 47 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.44503914 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.40053321 |
| 49 | EWS_26573619_Chip-Seq_HEK293_Human | 1.37335300 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33236728 |
| 51 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.31072796 |
| 52 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.31066964 |
| 53 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.29028984 |
| 54 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.27178403 |
| 55 | * IRF1_19129219_ChIP-ChIP_H3396_Human | 1.27141994 |
| 56 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.26800557 |
| 57 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26462018 |
| 58 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.26179030 |
| 59 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.24723863 |
| 60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23702382 |
| 61 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.22842051 |
| 62 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.22312237 |
| 63 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.22039065 |
| 64 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.18960373 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.18506731 |
| 66 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.18031496 |
| 67 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.15394065 |
| 68 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14867017 |
| 69 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.14292857 |
| 70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.13568983 |
| 71 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.12078484 |
| 72 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.11631518 |
| 73 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.09786563 |
| 74 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.08941187 |
| 75 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08793780 |
| 76 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08471334 |
| 77 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.07749211 |
| 78 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.06393571 |
| 79 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.05685164 |
| 80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05639349 |
| 81 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.04182690 |
| 82 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.04182690 |
| 83 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.02774808 |
| 84 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.02614733 |
| 85 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02440347 |
| 86 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.02027369 |
| 87 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.01734396 |
| 88 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.01612981 |
| 89 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.01594868 |
| 90 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.00538003 |
| 91 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.00528252 |
| 92 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00276462 |
| 93 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.98569963 |
| 94 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.97854298 |
| 95 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.96681538 |
| 96 | * STAT3_23295773_ChIP-Seq_U87_Human | 0.95684701 |
| 97 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.93791423 |
| 98 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.93610540 |
| 99 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.93484475 |
| 100 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.92908468 |
| 101 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.92740560 |
| 102 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92282387 |
| 103 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91542294 |
| 104 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90377606 |
| 105 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88594211 |
| 106 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.88567450 |
| 107 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88567450 |
| 108 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.88470577 |
| 109 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88436895 |
| 110 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.87999834 |
| 111 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.87822607 |
| 112 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.87042212 |
| 113 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.86963873 |
| 114 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.86709769 |
| 115 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.86058385 |
| 116 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.85975094 |
| 117 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.85385471 |
| 118 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.82758554 |
| 119 | MYC_22102868_ChIP-Seq_BL_Human | 0.81705520 |
| 120 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.80860075 |
| 121 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.80246154 |
| 122 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.77892904 |
| 123 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.76731997 |
| 124 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.76422476 |
| 125 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.76169161 |
| 126 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.75124239 |
| 127 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.73755497 |
| 128 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.73552502 |
| 129 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.69642012 |
| 130 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.68775717 |
| 131 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.68261125 |
| 132 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.67666886 |
| 133 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.67464789 |
| 134 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.67454042 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.35887476 |
| 2 | MP0008057_abnormal_DNA_replication | 4.06475373 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.90167094 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.57606516 |
| 5 | MP0008058_abnormal_DNA_repair | 3.56198281 |
| 6 | MP0003077_abnormal_cell_cycle | 3.25475264 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.99818483 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.98669411 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.78356360 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.42255934 |
| 11 | MP0003121_genomic_imprinting | 2.37229411 |
| 12 | MP0003787_abnormal_imprinting | 2.20027670 |
| 13 | MP0010307_abnormal_tumor_latency | 2.07579813 |
| 14 | MP0003123_paternal_imprinting | 2.05558627 |
| 15 | MP0008932_abnormal_embryonic_tissue | 1.91288578 |
| 16 | MP0003786_premature_aging | 1.82963496 |
| 17 | MP0000350_abnormal_cell_proliferation | 1.78610165 |
| 18 | MP0003890_abnormal_embryonic-extraembry | 1.74696508 |
| 19 | MP0006292_abnormal_olfactory_placode | 1.74024009 |
| 20 | MP0004808_abnormal_hematopoietic_stem | 1.66965019 |
| 21 | MP0010352_gastrointestinal_tract_polyps | 1.66226103 |
| 22 | MP0003221_abnormal_cardiomyocyte_apopto | 1.46939223 |
| 23 | MP0002009_preneoplasia | 1.43767016 |
| 24 | MP0009697_abnormal_copulation | 1.42196152 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.39997362 |
| 26 | MP0005380_embryogenesis_phenotype | 1.39997362 |
| 27 | MP0002210_abnormal_sex_determination | 1.39092807 |
| 28 | MP0000015_abnormal_ear_pigmentation | 1.36759326 |
| 29 | MP0000490_abnormal_crypts_of | 1.35151676 |
| 30 | MP0003763_abnormal_thymus_physiology | 1.34799963 |
| 31 | MP0001730_embryonic_growth_arrest | 1.32910164 |
| 32 | MP0005076_abnormal_cell_differentiation | 1.32014570 |
| 33 | MP0002095_abnormal_skin_pigmentation | 1.30151576 |
| 34 | MP0002233_abnormal_nose_morphology | 1.29590663 |
| 35 | MP0001529_abnormal_vocalization | 1.29556337 |
| 36 | MP0000569_abnormal_digit_pigmentation | 1.26441665 |
| 37 | MP0000631_abnormal_neuroendocrine_gland | 1.25086197 |
| 38 | MP0002085_abnormal_embryonic_tissue | 1.24112948 |
| 39 | MP0003984_embryonic_growth_retardation | 1.24001225 |
| 40 | MP0001293_anophthalmia | 1.22965391 |
| 41 | MP0001697_abnormal_embryo_size | 1.22770233 |
| 42 | MP0002084_abnormal_developmental_patter | 1.21513079 |
| 43 | MP0003937_abnormal_limbs/digits/tail_de | 1.21220138 |
| 44 | MP0002088_abnormal_embryonic_growth/wei | 1.20420288 |
| 45 | MP0008789_abnormal_olfactory_epithelium | 1.19528063 |
| 46 | MP0001188_hyperpigmentation | 1.16836338 |
| 47 | MP0006072_abnormal_retinal_apoptosis | 1.16102143 |
| 48 | MP0010030_abnormal_orbit_morphology | 1.15360167 |
| 49 | MP0002938_white_spotting | 1.15044168 |
| 50 | MP0004197_abnormal_fetal_growth/weight/ | 1.14750402 |
| 51 | MP0002086_abnormal_extraembryonic_tissu | 1.14573175 |
| 52 | MP0002638_abnormal_pupillary_reflex | 1.14106345 |
| 53 | MP0003943_abnormal_hepatobiliary_system | 1.13462078 |
| 54 | MP0005499_abnormal_olfactory_system | 1.13176886 |
| 55 | MP0005394_taste/olfaction_phenotype | 1.13176886 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.12467916 |
| 57 | MP0003880_abnormal_central_pattern | 1.10953269 |
| 58 | MP0005171_absent_coat_pigmentation | 1.10201945 |
| 59 | MP0003941_abnormal_skin_development | 1.10014023 |
| 60 | MP0001929_abnormal_gametogenesis | 1.09530251 |
| 61 | MP0002751_abnormal_autonomic_nervous | 1.09502714 |
| 62 | MP0001177_atelectasis | 1.09130812 |
| 63 | MP0000313_abnormal_cell_death | 1.08090225 |
| 64 | MP0000703_abnormal_thymus_morphology | 1.08072800 |
| 65 | MP0001145_abnormal_male_reproductive | 1.08057351 |
| 66 | MP0001119_abnormal_female_reproductive | 1.06887083 |
| 67 | MP0003119_abnormal_digestive_system | 1.06328964 |
| 68 | MP0000566_synostosis | 1.06062054 |
| 69 | MP0002697_abnormal_eye_size | 1.06052660 |
| 70 | MP0002019_abnormal_tumor_incidence | 1.04615478 |
| 71 | MP0001984_abnormal_olfaction | 1.02584189 |
| 72 | MP0002080_prenatal_lethality | 1.01854981 |
| 73 | MP0006054_spinal_hemorrhage | 1.01714883 |
| 74 | MP0000778_abnormal_nervous_system | 1.00740833 |
| 75 | MP0002160_abnormal_reproductive_system | 1.00641838 |
| 76 | MP0008995_early_reproductive_senescence | 1.00239489 |
| 77 | MP0000653_abnormal_sex_gland | 0.99394853 |
| 78 | MP0002398_abnormal_bone_marrow | 0.98646589 |
| 79 | MP0003718_maternal_effect | 0.97649776 |
| 80 | MP0001286_abnormal_eye_development | 0.97193000 |
| 81 | MP0003861_abnormal_nervous_system | 0.96852778 |
| 82 | MP0005389_reproductive_system_phenotype | 0.96627749 |
| 83 | MP0009703_decreased_birth_body | 0.95378646 |
| 84 | MP0005391_vision/eye_phenotype | 0.94182218 |
| 85 | MP0003567_abnormal_fetal_cardiomyocyte | 0.93902984 |
| 86 | MP0003698_abnormal_male_reproductive | 0.93554439 |
| 87 | MP0002006_tumorigenesis | 0.93428611 |
| 88 | MP0005253_abnormal_eye_physiology | 0.91700464 |
| 89 | MP0005397_hematopoietic_system_phenotyp | 0.91605236 |
| 90 | MP0001545_abnormal_hematopoietic_system | 0.91605236 |
| 91 | MP0002102_abnormal_ear_morphology | 0.88082841 |
| 92 | MP0000516_abnormal_urinary_system | 0.87541076 |
| 93 | MP0005367_renal/urinary_system_phenotyp | 0.87541076 |
| 94 | MP0003935_abnormal_craniofacial_develop | 0.86130953 |
| 95 | MP0002075_abnormal_coat/hair_pigmentati | 0.83506856 |
| 96 | MP0001919_abnormal_reproductive_system | 0.83180321 |
| 97 | MP0003122_maternal_imprinting | 0.83167064 |
| 98 | MP0000432_abnormal_head_morphology | 0.81945204 |
| 99 | MP0001186_pigmentation_phenotype | 0.81413062 |
| 100 | MP0003755_abnormal_palate_morphology | 0.81198005 |
| 101 | MP0005187_abnormal_penis_morphology | 0.80282013 |
| 102 | MP0005671_abnormal_response_to | 0.78320652 |
| 103 | MP0003315_abnormal_perineum_morphology | 0.76697498 |
| 104 | MP0002177_abnormal_outer_ear | 0.75187052 |
| 105 | MP0002111_abnormal_tail_morphology | 0.75117607 |
| 106 | MP0002928_abnormal_bile_duct | 0.74972903 |
| 107 | MP0006276_abnormal_autonomic_nervous | 0.74461925 |
| 108 | MP0002166_altered_tumor_susceptibility | 0.73585015 |
| 109 | MP0005645_abnormal_hypothalamus_physiol | 0.73158541 |
| 110 | MP0002722_abnormal_immune_system | 0.73141032 |
| 111 | MP0005075_abnormal_melanosome_morpholog | 0.72870983 |
| 112 | MP0000689_abnormal_spleen_morphology | 0.71518819 |
| 113 | MP0009672_abnormal_birth_weight | 0.70884140 |
| 114 | MP0002092_abnormal_eye_morphology | 0.70440383 |
| 115 | MP0002081_perinatal_lethality | 0.69447493 |
| 116 | MP0003136_yellow_coat_color | 0.69327427 |
| 117 | MP0001835_abnormal_antigen_presentation | 0.69057779 |
| 118 | MP0004134_abnormal_chest_morphology | 0.68776622 |
| 119 | MP0000372_irregular_coat_pigmentation | 0.68538533 |
| 120 | MP0003115_abnormal_respiratory_system | 0.68410702 |
| 121 | MP0005174_abnormal_tail_pigmentation | 0.68108153 |
| 122 | MP0000428_abnormal_craniofacial_morphol | 0.67610767 |
| 123 | MP0000049_abnormal_middle_ear | 0.66944480 |
| 124 | MP0009333_abnormal_splenocyte_physiolog | 0.66691986 |
| 125 | MP0002163_abnormal_gland_morphology | 0.66513691 |
| 126 | MP0002109_abnormal_limb_morphology | 0.66057307 |
| 127 | MP0003942_abnormal_urinary_system | 0.65223297 |
| 128 | MP0003938_abnormal_ear_development | 0.64691746 |
| 129 | MP0000647_abnormal_sebaceous_gland | 0.64671429 |
| 130 | MP0002116_abnormal_craniofacial_bone | 0.63070670 |
| 131 | MP0002184_abnormal_innervation | 0.62457951 |
| 132 | MP0008961_abnormal_basal_metabolism | 0.60535391 |
| 133 | MP0008770_decreased_survivor_rate | 0.57949847 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 4.70250019 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.49466474 |
| 3 | Abnormality of chromosome stability (HP:0003220) | 3.65823964 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 3.55396651 |
| 5 | Volvulus (HP:0002580) | 3.28300211 |
| 6 | Meckel diverticulum (HP:0002245) | 3.25156967 |
| 7 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.18556283 |
| 8 | Abnormality of the ileum (HP:0001549) | 3.09764825 |
| 9 | Ectopic kidney (HP:0000086) | 3.07866037 |
| 10 | Abnormality of the preputium (HP:0100587) | 3.05830585 |
| 11 | Cortical dysplasia (HP:0002539) | 2.94278361 |
| 12 | Medulloblastoma (HP:0002885) | 2.75833576 |
| 13 | Small intestinal stenosis (HP:0012848) | 2.72383333 |
| 14 | Duodenal stenosis (HP:0100867) | 2.72383333 |
| 15 | Abnormality of the fingertips (HP:0001211) | 2.69786175 |
| 16 | Colon cancer (HP:0003003) | 2.68395553 |
| 17 | Myelodysplasia (HP:0002863) | 2.59983794 |
| 18 | Abnormality of the labia minora (HP:0012880) | 2.57679567 |
| 19 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.57613125 |
| 20 | Patellar aplasia (HP:0006443) | 2.50663805 |
| 21 | Embryonal renal neoplasm (HP:0011794) | 2.49503177 |
| 22 | Papillary thyroid carcinoma (HP:0002895) | 2.49289381 |
| 23 | Abnormality of the carotid arteries (HP:0005344) | 2.47319591 |
| 24 | 11 pairs of ribs (HP:0000878) | 2.45887494 |
| 25 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.44708457 |
| 26 | Short 4th metacarpal (HP:0010044) | 2.44708457 |
| 27 | Acute myeloid leukemia (HP:0004808) | 2.41249282 |
| 28 | Clubbing of toes (HP:0100760) | 2.36542334 |
| 29 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.35692868 |
| 30 | Impulsivity (HP:0100710) | 2.30231760 |
| 31 | Sloping forehead (HP:0000340) | 2.29545546 |
| 32 | Agnosia (HP:0010524) | 2.27679205 |
| 33 | Abnormality of the duodenum (HP:0002246) | 2.25015583 |
| 34 | Abnormal lung lobation (HP:0002101) | 2.24147816 |
| 35 | Bone marrow hypocellularity (HP:0005528) | 2.20356442 |
| 36 | Pancreatic cysts (HP:0001737) | 2.10549898 |
| 37 | Increased nuchal translucency (HP:0010880) | 2.10428382 |
| 38 | Abnormality of the anterior horn cell (HP:0006802) | 2.09503539 |
| 39 | Degeneration of anterior horn cells (HP:0002398) | 2.09503539 |
| 40 | Deep philtrum (HP:0002002) | 2.09269938 |
| 41 | Supernumerary spleens (HP:0009799) | 2.08523450 |
| 42 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.08154598 |
| 43 | Abnormality of chromosome segregation (HP:0002916) | 2.02778519 |
| 44 | Abnormality of DNA repair (HP:0003254) | 2.02591507 |
| 45 | Glioma (HP:0009733) | 1.99207986 |
| 46 | Prostate neoplasm (HP:0100787) | 1.95476286 |
| 47 | Chronic hepatic failure (HP:0100626) | 1.93883375 |
| 48 | Intestinal atresia (HP:0011100) | 1.89731379 |
| 49 | Absent radius (HP:0003974) | 1.89239944 |
| 50 | Breast hypoplasia (HP:0003187) | 1.87044145 |
| 51 | Embryonal neoplasm (HP:0002898) | 1.86831537 |
| 52 | Rhabdomyosarcoma (HP:0002859) | 1.86625431 |
| 53 | Aplastic anemia (HP:0001915) | 1.85418860 |
| 54 | Stomach cancer (HP:0012126) | 1.84569696 |
| 55 | Long eyelashes (HP:0000527) | 1.83991314 |
| 56 | Neoplasm of the colon (HP:0100273) | 1.82931831 |
| 57 | Premature graying of hair (HP:0002216) | 1.82492380 |
| 58 | Neoplasm of the oral cavity (HP:0100649) | 1.82199854 |
| 59 | Short middle phalanx of the 5th finger (HP:0004220) | 1.81707222 |
| 60 | Abnormal number of incisors (HP:0011064) | 1.80741595 |
| 61 | Oligodactyly (hands) (HP:0001180) | 1.80368905 |
| 62 | Selective tooth agenesis (HP:0001592) | 1.79381519 |
| 63 | Abnormality of the incisor (HP:0000676) | 1.78093462 |
| 64 | True hermaphroditism (HP:0010459) | 1.77417734 |
| 65 | Abnormal spermatogenesis (HP:0008669) | 1.76756241 |
| 66 | Abnormality of the pons (HP:0007361) | 1.76326734 |
| 67 | Aqueductal stenosis (HP:0002410) | 1.75917491 |
| 68 | Abnormal hair whorl (HP:0010721) | 1.75772756 |
| 69 | Drooling (HP:0002307) | 1.75458095 |
| 70 | Abnormality of the renal collecting system (HP:0004742) | 1.75097236 |
| 71 | Lip pit (HP:0100267) | 1.75038069 |
| 72 | Optic nerve coloboma (HP:0000588) | 1.74934168 |
| 73 | Abnormality of the nasal septum (HP:0000419) | 1.74167836 |
| 74 | Truncal obesity (HP:0001956) | 1.73280153 |
| 75 | Combined immunodeficiency (HP:0005387) | 1.73199375 |
| 76 | Small hand (HP:0200055) | 1.72790864 |
| 77 | Absent forearm bone (HP:0003953) | 1.71720722 |
| 78 | Aplasia involving forearm bones (HP:0009822) | 1.71720722 |
| 79 | Thyroid carcinoma (HP:0002890) | 1.71414174 |
| 80 | Cafe-au-lait spot (HP:0000957) | 1.71250262 |
| 81 | Short thumb (HP:0009778) | 1.70502676 |
| 82 | Prominent nose (HP:0000448) | 1.70380737 |
| 83 | Neoplasm of striated muscle (HP:0009728) | 1.70074906 |
| 84 | Protruding tongue (HP:0010808) | 1.69269345 |
| 85 | Pancreatic fibrosis (HP:0100732) | 1.68982285 |
| 86 | Neoplasm of the adrenal cortex (HP:0100641) | 1.68635303 |
| 87 | Triphalangeal thumb (HP:0001199) | 1.68434220 |
| 88 | Deviation of the thumb (HP:0009603) | 1.68061902 |
| 89 | Abnormality of the astrocytes (HP:0100707) | 1.68060578 |
| 90 | Astrocytoma (HP:0009592) | 1.68060578 |
| 91 | Oral leukoplakia (HP:0002745) | 1.67947375 |
| 92 | Severe combined immunodeficiency (HP:0004430) | 1.67681482 |
| 93 | Abnormality of the metopic suture (HP:0005556) | 1.67199545 |
| 94 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.67110273 |
| 95 | Gonadotropin excess (HP:0000837) | 1.65659859 |
| 96 | Astigmatism (HP:0000483) | 1.65163774 |
| 97 | Septo-optic dysplasia (HP:0100842) | 1.64791663 |
| 98 | Duplicated collecting system (HP:0000081) | 1.64657240 |
| 99 | Hypoplasia of the pons (HP:0012110) | 1.64051663 |
| 100 | Capillary hemangiomas (HP:0005306) | 1.63982951 |
| 101 | Cystic hygroma (HP:0000476) | 1.63947912 |
| 102 | Abnormality of the septum pellucidum (HP:0007375) | 1.63729712 |
| 103 | Ependymoma (HP:0002888) | 1.63631239 |
| 104 | Optic nerve hypoplasia (HP:0000609) | 1.62863114 |
| 105 | Neoplasm of the pancreas (HP:0002894) | 1.62615487 |
| 106 | Proximal placement of thumb (HP:0009623) | 1.62390868 |
| 107 | Hepatoblastoma (HP:0002884) | 1.62039103 |
| 108 | Absent thumb (HP:0009777) | 1.61089496 |
| 109 | Tracheoesophageal fistula (HP:0002575) | 1.60951682 |
| 110 | Acute lymphatic leukemia (HP:0006721) | 1.60778120 |
| 111 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.60763880 |
| 112 | Absent frontal sinuses (HP:0002688) | 1.60548786 |
| 113 | Carpal bone hypoplasia (HP:0001498) | 1.60528359 |
| 114 | Renal cortical cysts (HP:0000803) | 1.60147131 |
| 115 | Long clavicles (HP:0000890) | 1.60115323 |
| 116 | Lymphoma (HP:0002665) | 1.58133139 |
| 117 | Arteriovenous malformation (HP:0100026) | 1.57199597 |
| 118 | Abnormality of the prostate (HP:0008775) | 1.56485528 |
| 119 | Missing ribs (HP:0000921) | 1.56347717 |
| 120 | Excessive salivation (HP:0003781) | 1.56257815 |
| 121 | Amaurosis fugax (HP:0100576) | 1.56024103 |
| 122 | Increased number of teeth (HP:0011069) | 1.55508733 |
| 123 | Mesomelia (HP:0003027) | 1.55501530 |
| 124 | Atresia of the external auditory canal (HP:0000413) | 1.54854920 |
| 125 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.54239245 |
| 126 | Microtia (HP:0008551) | 1.53928844 |
| 127 | Preaxial hand polydactyly (HP:0001177) | 1.53556778 |
| 128 | IgM deficiency (HP:0002850) | 1.53331243 |
| 129 | Dandy-Walker malformation (HP:0001305) | 1.52678001 |
| 130 | Prominent metopic ridge (HP:0005487) | 1.52301289 |
| 131 | Nephronophthisis (HP:0000090) | 1.51735533 |
| 132 | High pitched voice (HP:0001620) | 1.50586121 |
| 133 | Thyroiditis (HP:0100646) | 1.49876090 |
| 134 | Cupped ear (HP:0000378) | 1.49658000 |
| 135 | Neoplasm of the small intestine (HP:0100833) | 1.49512383 |
| 136 | Stenosis of the external auditory canal (HP:0000402) | 1.49201874 |
| 137 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.48789969 |
| 138 | Convex nasal ridge (HP:0000444) | 1.48145329 |
| 139 | Slender long bone (HP:0003100) | 1.48063728 |
| 140 | Lissencephaly (HP:0001339) | 1.47418654 |
| 141 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.47261277 |
| 142 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.47261277 |
| 143 | Hypoplastic labia majora (HP:0000059) | 1.46356934 |
| 144 | Poor coordination (HP:0002370) | 1.46259619 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.28864175 |
| 2 | SRPK1 | 3.33541236 |
| 3 | PLK4 | 2.87984977 |
| 4 | WEE1 | 2.84217969 |
| 5 | ACVR1B | 2.63776279 |
| 6 | ZAK | 2.54063222 |
| 7 | MAP3K4 | 2.42893541 |
| 8 | NEK2 | 2.36751493 |
| 9 | BRSK2 | 2.31927803 |
| 10 | TNIK | 2.29177098 |
| 11 | CDK12 | 2.26927771 |
| 12 | VRK1 | 2.23043849 |
| 13 | BUB1 | 2.20980280 |
| 14 | MKNK2 | 2.16094492 |
| 15 | PLK3 | 2.11888526 |
| 16 | TSSK6 | 2.09801259 |
| 17 | TTK | 2.08953823 |
| 18 | MKNK1 | 2.08683788 |
| 19 | CCNB1 | 2.06001846 |
| 20 | ATR | 2.05640382 |
| 21 | TRIM28 | 1.92654185 |
| 22 | PLK1 | 1.86340948 |
| 23 | LATS1 | 1.84710956 |
| 24 | WNK3 | 1.82523682 |
| 25 | RPS6KA4 | 1.78029157 |
| 26 | CHEK2 | 1.75534123 |
| 27 | MAP2K7 | 1.60620575 |
| 28 | AURKB | 1.57620368 |
| 29 | IRAK4 | 1.55866960 |
| 30 | TXK | 1.47524470 |
| 31 | TLK1 | 1.41442440 |
| 32 | STK3 | 1.38723534 |
| 33 | STK4 | 1.38401077 |
| 34 | CHEK1 | 1.35433036 |
| 35 | ERBB3 | 1.34618509 |
| 36 | AKT3 | 1.33925234 |
| 37 | PASK | 1.33358494 |
| 38 | TAF1 | 1.32517650 |
| 39 | EIF2AK2 | 1.31893280 |
| 40 | ATM | 1.30724257 |
| 41 | YES1 | 1.29508387 |
| 42 | CDK7 | 1.27593122 |
| 43 | BRD4 | 1.27228637 |
| 44 | CDK8 | 1.27085920 |
| 45 | DYRK3 | 1.26440442 |
| 46 | EIF2AK1 | 1.23326961 |
| 47 | NUAK1 | 1.22290776 |
| 48 | STK38L | 1.21760077 |
| 49 | EIF2AK3 | 1.17656952 |
| 50 | MELK | 1.17088410 |
| 51 | FRK | 1.16979495 |
| 52 | BRSK1 | 1.16647379 |
| 53 | MAP3K10 | 1.13416545 |
| 54 | NEK1 | 1.06786221 |
| 55 | CASK | 1.06616233 |
| 56 | STK24 | 1.01506626 |
| 57 | CDK4 | 1.01108195 |
| 58 | MAPK13 | 0.95409847 |
| 59 | PIM1 | 0.94958324 |
| 60 | CDK3 | 0.94558648 |
| 61 | TGFBR1 | 0.93739322 |
| 62 | SGK2 | 0.92351226 |
| 63 | CDK2 | 0.89646348 |
| 64 | MST4 | 0.88540978 |
| 65 | RPS6KB2 | 0.85262793 |
| 66 | CHUK | 0.85130610 |
| 67 | CLK1 | 0.84550368 |
| 68 | CDK1 | 0.83256243 |
| 69 | FGFR2 | 0.80530718 |
| 70 | MAP3K14 | 0.78782941 |
| 71 | IRAK3 | 0.78524500 |
| 72 | CSNK1G1 | 0.74938108 |
| 73 | PBK | 0.73957777 |
| 74 | MAP4K2 | 0.73609223 |
| 75 | TEC | 0.73196845 |
| 76 | PNCK | 0.69972290 |
| 77 | CDK9 | 0.69614937 |
| 78 | STK10 | 0.67709698 |
| 79 | RPS6KA5 | 0.67182320 |
| 80 | CDK6 | 0.65068869 |
| 81 | CSNK1A1L | 0.64053992 |
| 82 | NLK | 0.62220025 |
| 83 | CAMK1G | 0.59543151 |
| 84 | INSRR | 0.59171778 |
| 85 | CAMKK2 | 0.58663598 |
| 86 | PRPF4B | 0.57915234 |
| 87 | TRPM7 | 0.56049977 |
| 88 | FGFR1 | 0.55385113 |
| 89 | NEK6 | 0.55114261 |
| 90 | TAOK3 | 0.54253864 |
| 91 | AURKA | 0.54186373 |
| 92 | STK16 | 0.53908208 |
| 93 | CSNK1G2 | 0.51603984 |
| 94 | PLK2 | 0.51105669 |
| 95 | FGFR3 | 0.50897973 |
| 96 | RPS6KB1 | 0.50796238 |
| 97 | EEF2K | 0.50510804 |
| 98 | MAP3K8 | 0.49986909 |
| 99 | JAK3 | 0.49327689 |
| 100 | CSNK1G3 | 0.48361971 |
| 101 | CSNK2A1 | 0.47703829 |
| 102 | MAPK14 | 0.47424514 |
| 103 | SIK3 | 0.46645963 |
| 104 | MAP2K4 | 0.45828661 |
| 105 | EPHA3 | 0.45725363 |
| 106 | BMPR1B | 0.45231180 |
| 107 | PRKDC | 0.45181416 |
| 108 | KIT | 0.44929825 |
| 109 | DYRK2 | 0.44820461 |
| 110 | SGK3 | 0.43511494 |
| 111 | SIK2 | 0.42786477 |
| 112 | NEK9 | 0.42615393 |
| 113 | MAP4K1 | 0.42183302 |
| 114 | CSNK2A2 | 0.39979975 |
| 115 | CAMK1D | 0.38802221 |
| 116 | AKT1 | 0.38471358 |
| 117 | CSNK1E | 0.35962246 |
| 118 | UHMK1 | 0.35433606 |
| 119 | MARK1 | 0.34178321 |
| 120 | CSF1R | 0.33925462 |
| 121 | IKBKE | 0.32670604 |
| 122 | IKBKB | 0.31997623 |
| 123 | SGK223 | 0.31055338 |
| 124 | SGK494 | 0.31055338 |
| 125 | GSK3B | 0.30910474 |
| 126 | EPHA2 | 0.28560319 |
| 127 | MAPK1 | 0.26869239 |
| 128 | CSNK1D | 0.26449831 |
| 129 | BCR | 0.25087767 |
| 130 | IRAK1 | 0.24784725 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.14081364 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.83146035 |
| 3 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 3.20302353 |
| 4 | Homologous recombination_Homo sapiens_hsa03440 | 3.01587177 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 3.01225104 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.96288257 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.91655609 |
| 8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.70472135 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67273822 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.52695209 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.45559187 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.18582281 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.16289875 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.14987552 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 2.13623018 |
| 16 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.95617464 |
| 17 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.68220552 |
| 18 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.67153509 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.65842053 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.50820179 |
| 21 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.37312819 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.30311198 |
| 23 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.28851586 |
| 24 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.18110544 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.13632842 |
| 26 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.13540583 |
| 27 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.12123979 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.11559458 |
| 29 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.10776953 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.10726389 |
| 31 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.10196318 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08960215 |
| 33 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.08606764 |
| 34 | HTLV-I infection_Homo sapiens_hsa05166 | 1.07708108 |
| 35 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.03964225 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.03496767 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.03053115 |
| 38 | Nicotine addiction_Homo sapiens_hsa05033 | 1.02045396 |
| 39 | Measles_Homo sapiens_hsa05162 | 0.98780062 |
| 40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.96848846 |
| 41 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.89784725 |
| 42 | Proteasome_Homo sapiens_hsa03050 | 0.89618238 |
| 43 | Alcoholism_Homo sapiens_hsa05034 | 0.87019327 |
| 44 | Colorectal cancer_Homo sapiens_hsa05210 | 0.85994327 |
| 45 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.84624460 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.84032152 |
| 47 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.80396790 |
| 48 | Taste transduction_Homo sapiens_hsa04742 | 0.78072207 |
| 49 | Hepatitis B_Homo sapiens_hsa05161 | 0.77631929 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.75649565 |
| 51 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.75333624 |
| 52 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.74175039 |
| 53 | Adherens junction_Homo sapiens_hsa04520 | 0.72629149 |
| 54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.72374414 |
| 55 | Prostate cancer_Homo sapiens_hsa05215 | 0.71902374 |
| 56 | Thyroid cancer_Homo sapiens_hsa05216 | 0.70537674 |
| 57 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.70408550 |
| 58 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.70299371 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.69751239 |
| 60 | Influenza A_Homo sapiens_hsa05164 | 0.68295650 |
| 61 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.68119406 |
| 62 | Olfactory transduction_Homo sapiens_hsa04740 | 0.65478698 |
| 63 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.65320452 |
| 64 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.62340239 |
| 65 | Allograft rejection_Homo sapiens_hsa05330 | 0.62152018 |
| 66 | Legionellosis_Homo sapiens_hsa05134 | 0.61496723 |
| 67 | Ribosome_Homo sapiens_hsa03010 | 0.59738251 |
| 68 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.58744721 |
| 69 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.57749439 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.56188504 |
| 71 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.55381548 |
| 72 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.54983601 |
| 73 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.54522263 |
| 74 | Pathways in cancer_Homo sapiens_hsa05200 | 0.53619486 |
| 75 | Apoptosis_Homo sapiens_hsa04210 | 0.53596650 |
| 76 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.52674181 |
| 77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.52269658 |
| 78 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.51697733 |
| 79 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.51309578 |
| 80 | Leishmaniasis_Homo sapiens_hsa05140 | 0.51169695 |
| 81 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.50446382 |
| 82 | Viral myocarditis_Homo sapiens_hsa05416 | 0.49106896 |
| 83 | Phototransduction_Homo sapiens_hsa04744 | 0.47688075 |
| 84 | Endometrial cancer_Homo sapiens_hsa05213 | 0.45871760 |
| 85 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.45828506 |
| 86 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45190414 |
| 87 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.44532379 |
| 88 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.44134530 |
| 89 | Circadian rhythm_Homo sapiens_hsa04710 | 0.43419973 |
| 90 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.41092155 |
| 91 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.40217615 |
| 92 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.39791865 |
| 93 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.39371041 |
| 94 | Protein export_Homo sapiens_hsa03060 | 0.39109504 |
| 95 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.38517200 |
| 96 | Shigellosis_Homo sapiens_hsa05131 | 0.38410865 |
| 97 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.38044409 |
| 98 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.37414852 |
| 99 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.36400153 |
| 100 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36257343 |
| 101 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.35691351 |
| 102 | Lysine degradation_Homo sapiens_hsa00310 | 0.35555066 |
| 103 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.35145119 |
| 104 | Melanoma_Homo sapiens_hsa05218 | 0.34070601 |
| 105 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33723178 |
| 106 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.32662383 |
| 107 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.31975067 |
| 108 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.30883460 |
| 109 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.29328662 |
| 110 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.29132837 |
| 111 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.28977508 |
| 112 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.28411446 |
| 113 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.28051374 |
| 114 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.27651218 |
| 115 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27548917 |
| 116 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.27033396 |
| 117 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26318745 |
| 118 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.26231515 |
| 119 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.25794958 |
| 120 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.24453418 |
| 121 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.24237167 |
| 122 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.24044470 |
| 123 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.22688446 |
| 124 | Long-term depression_Homo sapiens_hsa04730 | 0.21653960 |
| 125 | Morphine addiction_Homo sapiens_hsa05032 | 0.20712071 |
| 126 | Huntingtons disease_Homo sapiens_hsa05016 | 0.19815257 |
| 127 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.19752233 |
| 128 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18867955 |
| 129 | GABAergic synapse_Homo sapiens_hsa04727 | 0.17874059 |
| 130 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.17848116 |
| 131 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.17622578 |
| 132 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.16644668 |
| 133 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.12957898 |
| 134 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.12375148 |
| 135 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.11222125 |
| 136 | Glioma_Homo sapiens_hsa05214 | 0.10571324 |

