CTHRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.17632262
2extracellular fibril organization (GO:0043206)8.87032020
3collagen fibril organization (GO:0030199)8.78460998
4fibril organization (GO:0097435)7.45964381
5dermatan sulfate biosynthetic process (GO:0030208)6.20513618
6keratan sulfate catabolic process (GO:0042340)5.96857085
7bone trabecula formation (GO:0060346)5.83820276
8peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.81137169
9dermatan sulfate metabolic process (GO:0030205)5.70057705
10sequestering of extracellular ligand from receptor (GO:0035581)5.62263339
11chondrocyte development (GO:0002063)5.38580883
12chondrocyte proliferation (GO:0035988)4.98420981
13collagen metabolic process (GO:0032963)4.97944537
14skin morphogenesis (GO:0043589)4.94594727
15virion attachment to host cell (GO:0019062)4.94494959
16adhesion of symbiont to host cell (GO:0044650)4.94494959
17cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.91751075
18collagen catabolic process (GO:0030574)4.83389122
19cell migration involved in heart development (GO:0060973)4.77693348
20mesenchymal-epithelial cell signaling (GO:0060638)4.69224334
21multicellular organismal macromolecule metabolic process (GO:0044259)4.62602779
22basement membrane organization (GO:0071711)4.60308561
23endothelial cell morphogenesis (GO:0001886)4.55867846
24nucleotide-sugar biosynthetic process (GO:0009226)4.45164137
25multicellular organismal catabolic process (GO:0044243)4.40369215
26kidney mesenchyme development (GO:0072074)4.39078331
27multicellular organismal metabolic process (GO:0044236)4.35329476
28adhesion of symbiont to host (GO:0044406)4.25144774
29protein retention in ER lumen (GO:0006621)4.14545930
30endocardial cushion morphogenesis (GO:0003203)4.12930482
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.12502530
32lymph vessel development (GO:0001945)4.07442428
33blood vessel maturation (GO:0001955)4.05792735
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02816068
35metanephric mesenchyme development (GO:0072075)3.99628271
36type B pancreatic cell proliferation (GO:0044342)3.98413883
37vascular endothelial growth factor signaling pathway (GO:0038084)3.86057866
38extracellular matrix disassembly (GO:0022617)3.84139168
39short-term memory (GO:0007614)3.82599626
40cellular response to vitamin (GO:0071295)3.82383941
41mesenchyme morphogenesis (GO:0072132)3.80350252
42axon extension involved in axon guidance (GO:0048846)3.80300336
43neuron projection extension involved in neuron projection guidance (GO:1902284)3.80300336
44endodermal cell differentiation (GO:0035987)3.76744604
45peptidyl-proline hydroxylation (GO:0019511)3.72616302
46chondroitin sulfate biosynthetic process (GO:0030206)3.70159302
47extracellular matrix organization (GO:0030198)3.69157141
48extracellular structure organization (GO:0043062)3.67591945
49regulation of cardiac muscle cell apoptotic process (GO:0010665)3.67380600
50substrate-dependent cell migration (GO:0006929)3.67139806
51extracellular regulation of signal transduction (GO:1900115)3.66922850
52extracellular negative regulation of signal transduction (GO:1900116)3.66922850
53notochord development (GO:0030903)3.65537073
54venous blood vessel morphogenesis (GO:0048845)3.64482574
55tooth mineralization (GO:0034505)3.61655418
56craniofacial suture morphogenesis (GO:0097094)3.57973158
57regulation of striated muscle cell apoptotic process (GO:0010662)3.46672217
58cell aggregation (GO:0098743)3.43313683
59cartilage condensation (GO:0001502)3.43313683
60regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.40736119
61response to gravity (GO:0009629)3.39836528
62endocardial cushion development (GO:0003197)3.35229403
63cellular response to vitamin D (GO:0071305)3.33745664
64UDP-N-acetylglucosamine metabolic process (GO:0006047)3.28265127
65opsonization (GO:0008228)3.27766308
66positive regulation of cartilage development (GO:0061036)3.25681892
67regulation of macrophage cytokine production (GO:0010935)3.24425411
68substrate adhesion-dependent cell spreading (GO:0034446)3.23840596
69outer ear morphogenesis (GO:0042473)3.21979436
70regulation of plasminogen activation (GO:0010755)3.20474250
71cell adhesion mediated by integrin (GO:0033627)3.19216812
72negative regulation of smooth muscle cell migration (GO:0014912)3.18551091
73wound healing, spreading of epidermal cells (GO:0035313)3.18098653
74somite development (GO:0061053)3.18020149
75protein hydroxylation (GO:0018126)3.17899791
76retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16503899
77positive regulation of blood vessel endothelial cell migration (GO:0043536)3.14736320
78cranial suture morphogenesis (GO:0060363)3.14667543
79chondroitin sulfate catabolic process (GO:0030207)3.14558510
80negative regulation of embryonic development (GO:0045992)3.14344978
81camera-type eye morphogenesis (GO:0048593)3.12584595
82protein trimerization (GO:0070206)3.11459989
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10273334
84positive regulation of epithelial to mesenchymal transition (GO:0010718)3.09157003
85stress fiber assembly (GO:0043149)3.09071770
86cellular response to BMP stimulus (GO:0071773)3.06855549
87response to BMP (GO:0071772)3.06855549
88glomerular basement membrane development (GO:0032836)3.05772907
89negative regulation of chondrocyte differentiation (GO:0032331)3.05373275
90hypotonic response (GO:0006971)3.03720860
91positive regulation of endothelial cell apoptotic process (GO:2000353)3.03507078
92regulation of integrin-mediated signaling pathway (GO:2001044)3.02964133
93apoptotic cell clearance (GO:0043277)3.01917530
94cardiac epithelial to mesenchymal transition (GO:0060317)2.99982613
95cellular response to amino acid stimulus (GO:0071230)2.99584014
96muscle cell migration (GO:0014812)2.99530589
97wound healing, spreading of cells (GO:0044319)2.96748999
98heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.96509051
99cell migration involved in sprouting angiogenesis (GO:0002042)2.95884973
100glomerular filtration (GO:0003094)2.94654571
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93753731
102barbed-end actin filament capping (GO:0051016)2.92491058
103negative regulation of osteoblast proliferation (GO:0033689)2.91092290
104COPII vesicle coating (GO:0048208)2.90169995
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90090452
106extracellular matrix assembly (GO:0085029)2.89903961
107negative regulation of smooth muscle cell differentiation (GO:0051151)2.89042628
108positive regulation of glycogen biosynthetic process (GO:0045725)2.86076065
109regulation of cartilage development (GO:0061035)2.85247991
110positive regulation of macrophage cytokine production (GO:0060907)2.84092165
111negative regulation of BMP signaling pathway (GO:0030514)2.83959518
112embryonic cranial skeleton morphogenesis (GO:0048701)2.83890373
113glomerulus development (GO:0032835)2.83263518
114regulation of extracellular matrix disassembly (GO:0010715)2.81899254
115epithelial to mesenchymal transition (GO:0001837)2.81647463
116negative regulation of biomineral tissue development (GO:0070168)2.81141960
117smooth muscle tissue development (GO:0048745)2.79558433
118negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.79454043
119regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.78693264
120hyaluronan catabolic process (GO:0030214)2.78214199
121positive regulation of stem cell differentiation (GO:2000738)2.76776337
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76399581
123glial cell migration (GO:0008347)2.74545124
124negative regulation of cartilage development (GO:0061037)2.74394761
125keratan sulfate biosynthetic process (GO:0018146)2.73978020
126protein localization to cell surface (GO:0034394)2.73929784
127aminoglycan biosynthetic process (GO:0006023)2.73339174
128glycosaminoglycan biosynthetic process (GO:0006024)2.73194213
129G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73158436
130regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70885202
131regulation of chondrocyte differentiation (GO:0032330)2.69310780
132regulation of collagen metabolic process (GO:0010712)2.69146691
133mesodermal cell differentiation (GO:0048333)2.68442205
134positive regulation of Rho protein signal transduction (GO:0035025)2.68431586
135artery development (GO:0060840)2.68368003
136regulation of smooth muscle cell migration (GO:0014910)2.67214803
137protein localization to endosome (GO:0036010)2.66859812
138negative regulation of adherens junction organization (GO:1903392)2.66066094
139negative regulation of focal adhesion assembly (GO:0051895)2.66066094
140negative regulation of cell junction assembly (GO:1901889)2.66066094
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.65879870
142glycosaminoglycan catabolic process (GO:0006027)2.65244541
143sprouting angiogenesis (GO:0002040)2.65238665
144negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.65119236
145mesenchyme development (GO:0060485)2.64867140
146cartilage development (GO:0051216)2.64436002
147pericardium development (GO:0060039)2.64296951
148COPI coating of Golgi vesicle (GO:0048205)2.63166995
149Golgi transport vesicle coating (GO:0048200)2.63166995
150skeletal system development (GO:0001501)2.62893875
151lung-associated mesenchyme development (GO:0060484)2.62307563
152regulation of epithelial to mesenchymal transition (GO:0010717)2.62006514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.33940782
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.41458083
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.12733961
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92504139
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.82441796
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.74999963
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.72598278
8* CJUN_26792858_Chip-Seq_BT549_Human2.60665481
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.60524296
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59961143
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.50218652
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.49405708
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39943200
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31719246
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21175089
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21175089
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11475103
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.08288087
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07336601
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04931472
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04595407
22AR_21572438_ChIP-Seq_LNCaP_Human2.03563937
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.02623367
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95535724
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.89985103
26TP53_18474530_ChIP-ChIP_U2OS_Human1.88765114
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87036092
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87028491
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86557738
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.83373341
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82737097
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.79150485
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.77913680
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77108678
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75547172
36GBX2_23144817_ChIP-Seq_PC3_Human1.75355582
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.73901252
38CLOCK_20551151_ChIP-Seq_293T_Human1.72237519
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70775094
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.70458187
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70304793
42TP53_16413492_ChIP-PET_HCT116_Human1.68826678
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67531422
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66279043
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66279043
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64352662
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57277721
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57277721
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56701773
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53786914
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51119206
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50321839
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47071900
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.46340627
55TP53_22127205_ChIP-Seq_IMR90_Human1.45146651
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45131956
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44827515
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44173367
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42965157
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42808900
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41681024
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.40673933
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39137279
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37526638
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36260844
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35530367
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31801956
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27616767
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27519080
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.26238300
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.26238300
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26088118
73FUS_26573619_Chip-Seq_HEK293_Human1.25750521
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25717231
75* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25374439
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23699301
77* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19545600
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.18090247
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14532769
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13143375
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12624046
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11584017
83TP53_23651856_ChIP-Seq_MEFs_Mouse1.11443997
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09994576
85SOX2_20726797_ChIP-Seq_SW620_Human1.08560799
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07319018
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.06563088
88* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04772118
89* P300_19829295_ChIP-Seq_ESCs_Human1.02821944
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02371179
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01533378
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01324211
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01243741
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00995898
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.00795192
96SMAD4_21799915_ChIP-Seq_A2780_Human1.00630387
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.00247345
98* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98991829
99EZH2_22144423_ChIP-Seq_EOC_Human0.97781796
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97579544
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.96877278
102ZNF274_21170338_ChIP-Seq_K562_Hela0.96066323
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95623221
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95621304
105* SA1_22415368_ChIP-Seq_MEFs_Mouse0.95198174
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95037505
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93788410
108ERG_21242973_ChIP-ChIP_JURKAT_Human0.93131621
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93129911
110* JUN_21703547_ChIP-Seq_K562_Human0.92949177
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92635601
112NFI_21473784_ChIP-Seq_ESCs_Mouse0.92412089
113BCAT_22108803_ChIP-Seq_LS180_Human0.92367485
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91330718
115* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91093091
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89670894
117AR_21909140_ChIP-Seq_LNCAP_Human0.89151025
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.88468564
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88038208
120* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87982233
121EOMES_21245162_ChIP-Seq_HESCs_Human0.87934543
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87493532
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87355796
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87160614
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87111529
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87061781
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86785077
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.86467885
129RACK7_27058665_Chip-Seq_MCF-7_Human0.85523024
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85018571
131CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84110850
132* TP63_23658742_ChIP-Seq_EP156T_Human0.84072699
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83876448
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82932141
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.82852662
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82851605
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82544907
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81867495
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.81814625
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81682469
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80498786
142* ATF3_27146783_Chip-Seq_COLON_Human0.80266291
143EGR1_19374776_ChIP-ChIP_THP-1_Human0.77395226
144PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.77338904
145AHR_22903824_ChIP-Seq_MCF-7_Human0.76998376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.64169375
2MP0008438_abnormal_cutaneous_collagen8.34850781
3MP0005275_abnormal_skin_tensile5.84636756
4MP0003279_aneurysm3.19031174
5MP0010368_abnormal_lymphatic_system2.87495841
6MP0001958_emphysema2.86662680
7MP0005508_abnormal_skeleton_morphology2.86635327
8MP0001542_abnormal_bone_strength2.76174695
9MP0002108_abnormal_muscle_morphology2.59913102
10MP0006054_spinal_hemorrhage2.51224681
11MP0009250_abnormal_appendicular_skeleto2.49317091
12MP0003705_abnormal_hypodermis_morpholog2.43047379
13MP0004272_abnormal_basement_membrane2.32782507
14MP0010030_abnormal_orbit_morphology2.20113549
15MP0009384_cardiac_valve_regurgitation2.16665072
16MP0004134_abnormal_chest_morphology2.13336623
17MP0002282_abnormal_trachea_morphology2.05682039
18MP0002060_abnormal_skin_morphology1.97333331
19MP0003122_maternal_imprinting1.73393339
20MP0005390_skeleton_phenotype1.68079515
21MP0002933_joint_inflammation1.65097948
22MP0002295_abnormal_pulmonary_circulatio1.64836602
23MP0003566_abnormal_cell_adhesion1.63028760
24MP0005257_abnormal_intraocular_pressure1.57839950
25MP0002932_abnormal_joint_morphology1.54022675
26MP0000163_abnormal_cartilage_morphology1.52034844
27MP0005171_absent_coat_pigmentation1.51924750
28MP0001243_abnormal_dermal_layer1.51588294
29MP0002896_abnormal_bone_mineralization1.47335320
30MP0003283_abnormal_digestive_organ1.42528580
31MP0001299_abnormal_eye_distance/1.39976261
32MP0005623_abnormal_meninges_morphology1.38743762
33MP0003385_abnormal_body_wall1.38420468
34MP0002115_abnormal_skeleton_extremities1.36694757
35MP0003941_abnormal_skin_development1.34856686
36MP0000049_abnormal_middle_ear1.34558696
37MP0009053_abnormal_anal_canal1.29982212
38MP0005023_abnormal_wound_healing1.28656399
39MP0002249_abnormal_larynx_morphology1.28128176
40MP0000013_abnormal_adipose_tissue1.26255782
41MP0001879_abnormal_lymphatic_vessel1.25015581
42* MP0002113_abnormal_skeleton_development1.21563397
43MP0003115_abnormal_respiratory_system1.20324260
44MP0003123_paternal_imprinting1.17084914
45MP0000751_myopathy1.16780575
46MP0003942_abnormal_urinary_system1.15566437
47MP0010352_gastrointestinal_tract_polyps1.11290007
48MP0002877_abnormal_melanocyte_morpholog1.05120223
49MP0003755_abnormal_palate_morphology1.05009893
50MP0002116_abnormal_craniofacial_bone1.04187317
51MP0002109_abnormal_limb_morphology1.02634945
52MP0002254_reproductive_system_inflammat1.02167517
53MP0010386_abnormal_urinary_bladder0.98490423
54MP0002233_abnormal_nose_morphology0.98273715
55MP0004858_abnormal_nervous_system0.97539481
56MP0000534_abnormal_ureter_morphology0.93614323
57MP0002111_abnormal_tail_morphology0.91110813
58MP0000432_abnormal_head_morphology0.89187846
59MP0003937_abnormal_limbs/digits/tail_de0.86295495
60MP0002938_white_spotting0.84521952
61MP0001533_abnormal_skeleton_physiology0.84400701
62MP0000428_abnormal_craniofacial_morphol0.84377922
63MP0003935_abnormal_craniofacial_develop0.84323280
64MP0002114_abnormal_axial_skeleton0.83463808
65MP0005197_abnormal_uvea_morphology0.82401102
66MP0001849_ear_inflammation0.82271172
67MP0005595_abnormal_vascular_smooth0.81596805
68MP0005165_increased_susceptibility_to0.80631554
69MP0001177_atelectasis0.79452610
70MP0001915_intracranial_hemorrhage0.79215119
71MP0000762_abnormal_tongue_morphology0.78492918
72MP0009780_abnormal_chondrocyte_physiolo0.74288739
73MP0005369_muscle_phenotype0.74240267
74MP0000759_abnormal_skeletal_muscle0.73171295
75MP0003091_abnormal_cell_migration0.72548277
76* MP0003795_abnormal_bone_structure0.72479869
77MP0002089_abnormal_postnatal_growth/wei0.71752389
78MP0000733_abnormal_muscle_development0.70853012
79MP0005058_abnormal_lysosome_morphology0.70660153
80MP0000767_abnormal_smooth_muscle0.70329387
81MP0000858_altered_metastatic_potential0.70220977
82MP0000750_abnormal_muscle_regeneration0.62881749
83MP0003121_genomic_imprinting0.62692411
84MP0006138_congestive_heart_failure0.62098935
85MP0000003_abnormal_adipose_tissue0.61945970
86MP0005388_respiratory_system_phenotype0.61330833
87MP0002133_abnormal_respiratory_system0.61330833
88MP0001175_abnormal_lung_morphology0.60150604
89MP0000537_abnormal_urethra_morphology0.59674500
90MP0004883_abnormal_blood_vessel0.58884327
91* MP0002998_abnormal_bone_remodeling0.58301989
92MP0004133_heterotaxia0.57473245
93MP0004484_altered_response_of0.56890755
94MP0003828_pulmonary_edema0.56620771
95MP0005164_abnormal_response_to0.56134735
96MP0002925_abnormal_cardiovascular_devel0.55693103
97MP0003938_abnormal_ear_development0.54966136
98MP0002168_other_aberrant_phenotype0.54618009
99MP0002128_abnormal_blood_circulation0.54062230
100MP0004233_abnormal_muscle_weight0.52990978
101MP0005084_abnormal_gallbladder_morpholo0.52533207
102MP0003300_gastrointestinal_ulcer0.52002403
103MP0003191_abnormal_cellular_cholesterol0.51269008
104MP0003950_abnormal_plasma_membrane0.49960449
105MP0005193_abnormal_anterior_eye0.49236565
106MP0005408_hypopigmentation0.49047347
107MP0002177_abnormal_outer_ear0.48872267
108MP0000343_altered_response_to0.48383753
109MP0010771_integument_phenotype0.47576683
110MP0003448_altered_tumor_morphology0.47385964
111MP0001348_abnormal_lacrimal_gland0.46884247
112MP0000538_abnormal_urinary_bladder0.45294319
113MP0000749_muscle_degeneration0.44611749
114MP0001614_abnormal_blood_vessel0.44488329
115MP0000566_synostosis0.42308331
116MP0000462_abnormal_digestive_system0.41131845
117MP0001270_distended_abdomen0.39990553
118MP0004197_abnormal_fetal_growth/weight/0.39770556
119MP0002972_abnormal_cardiac_muscle0.38889582

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.78895743
2Premature rupture of membranes (HP:0001788)7.65344320
3Soft skin (HP:0000977)5.05318137
4Neonatal short-limb short stature (HP:0008921)4.92771466
5Abnormality of dentin (HP:0010299)4.88572320
6Biconcave vertebral bodies (HP:0004586)4.74016135
7Aortic dissection (HP:0002647)4.32240070
8Atrophic scars (HP:0001075)4.00946323
9Shallow orbits (HP:0000586)3.81139869
10Wormian bones (HP:0002645)3.75957851
11Fragile skin (HP:0001030)3.74327222
12Bladder diverticulum (HP:0000015)3.68190558
13Irregular epiphyses (HP:0010582)3.64489083
14Broad metatarsal (HP:0001783)3.62489076
15Vertebral compression fractures (HP:0002953)3.59611154
16Blue sclerae (HP:0000592)3.58232035
17Mild short stature (HP:0003502)3.56850505
18Small epiphyses (HP:0010585)3.51096270
19Genu recurvatum (HP:0002816)3.48324198
20Epiphyseal dysplasia (HP:0002656)3.45028327
21Cervical subluxation (HP:0003308)3.30593351
22Dilatation of the ascending aorta (HP:0005111)3.27255309
23Ankle contracture (HP:0006466)3.26293056
24Osteoarthritis (HP:0002758)3.25585735
25Follicular hyperkeratosis (HP:0007502)2.90606153
26Mitral valve prolapse (HP:0001634)2.90018545
27Cerebral aneurysm (HP:0004944)2.88076372
28Abnormal delivery (HP:0001787)2.81723771
29Absent frontal sinuses (HP:0002688)2.80254967
30Beaking of vertebral bodies (HP:0004568)2.79836249
31Spinal rigidity (HP:0003306)2.74543183
32Hyperextensible skin (HP:0000974)2.72250953
33Abnormality of the acetabulum (HP:0003170)2.71933971
34Aortic aneurysm (HP:0004942)2.71057024
35Ulnar bowing (HP:0003031)2.68613647
36Broad ribs (HP:0000885)2.64621158
37Mildly elevated creatine phosphokinase (HP:0008180)2.64399468
38Peritonitis (HP:0002586)2.61203610
39Overgrowth (HP:0001548)2.60223432
40Wide anterior fontanel (HP:0000260)2.56789886
41Elbow flexion contracture (HP:0002987)2.56647981
42Hypoplastic ischia (HP:0003175)2.54308114
43Increased variability in muscle fiber diameter (HP:0003557)2.51819682
44Vitreoretinal degeneration (HP:0000655)2.50916747
45Platyspondyly (HP:0000926)2.50915539
46Narrow nasal bridge (HP:0000446)2.50435763
47Bell-shaped thorax (HP:0001591)2.49773254
48Joint laxity (HP:0001388)2.49069010
49Vascular tortuosity (HP:0004948)2.46691527
50Spondylolisthesis (HP:0003302)2.45534601
51Delayed epiphyseal ossification (HP:0002663)2.43300147
52Breech presentation (HP:0001623)2.41710597
53Decreased skull ossification (HP:0004331)2.36363924
54Broad long bones (HP:0005622)2.34984002
55Hypoventilation (HP:0002791)2.34054946
56Subacute progressive viral hepatitis (HP:0006572)2.33661466
57Aneurysm (HP:0002617)2.33103980
58Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.32579094
59Patent foramen ovale (HP:0001655)2.29648452
60Cupped ribs (HP:0000887)2.28752536
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25903114
62Coxa vara (HP:0002812)2.23500849
63Spinal cord compression (HP:0002176)2.21507899
64Alopecia of scalp (HP:0002293)2.21418317
65Mitral regurgitation (HP:0001653)2.19672677
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.18043123
67Abnormality of the ischium (HP:0003174)2.18031080
68Carpal bone hypoplasia (HP:0001498)2.17362638
69Ovoid vertebral bodies (HP:0003300)2.17186506
70Aortic valve stenosis (HP:0001650)2.16374837
71Morphological abnormality of the middle ear (HP:0008609)2.15334926
72Limited hip movement (HP:0008800)2.15095031
73Irregular vertebral endplates (HP:0003301)2.14569647
74Abnormality of skeletal muscle fiber size (HP:0012084)2.10776942
75Bowel diverticulosis (HP:0005222)2.09841497
76Wrist flexion contracture (HP:0001239)2.09571514
77Flat capital femoral epiphysis (HP:0003370)2.09341620
78Type 1 muscle fiber predominance (HP:0003803)2.09232096
79Cardiovascular calcification (HP:0011915)2.08577555
80Generalized amyotrophy (HP:0003700)2.06589407
81Mitral stenosis (HP:0001718)2.06255191
82Delayed cranial suture closure (HP:0000270)2.06060107
83Protruding ear (HP:0000411)2.05693734
84Infantile muscular hypotonia (HP:0008947)2.05275013
85Arterial tortuosity (HP:0005116)2.04600512
86Mesomelia (HP:0003027)2.03129349
87Hypoplasia of the odontoid process (HP:0003311)2.01220782
88Ectopia lentis (HP:0001083)2.01186001
89Short middle phalanx of the 5th finger (HP:0004220)2.00569119
90Pulmonary artery stenosis (HP:0004415)2.00396760
91Abnormality of skull ossification (HP:0002703)1.99010005
92Disproportionate tall stature (HP:0001519)1.98951337
93Hallux valgus (HP:0001822)1.97434625
94Osteolytic defects of the hand bones (HP:0009699)1.97135510
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.97135510
96Short hallux (HP:0010109)1.96924456
97Aortic regurgitation (HP:0001659)1.96118139
98Tibial bowing (HP:0002982)1.95406950
99Redundant skin (HP:0001582)1.95180691
100Flared iliac wings (HP:0002869)1.95079133
101Metaphyseal dysplasia (HP:0100255)1.94338558
102Osteopenia (HP:0000938)1.94320671
103Coronal craniosynostosis (HP:0004440)1.94152913
104Deviation of the hallux (HP:0010051)1.93562400
105Disproportionate short-trunk short stature (HP:0003521)1.90613906
106Nonimmune hydrops fetalis (HP:0001790)1.90606301
107Hip contracture (HP:0003273)1.88386524
108Venous abnormality (HP:0002624)1.88156911
109Abnormality of the vertebral endplates (HP:0005106)1.87921439
110Round ear (HP:0100830)1.86909775
111Genu varum (HP:0002970)1.86712768
112Delayed closure of the anterior fontanelle (HP:0001476)1.86176692
113Short nail (HP:0001799)1.85656718
114Tracheomalacia (HP:0002779)1.84786000
115Inguinal hernia (HP:0000023)1.82514397
116Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82315523
117Striae distensae (HP:0001065)1.82202825
118Abnormality of the frontal sinuses (HP:0002687)1.82174191
119Bowing of the arm (HP:0006488)1.81855628
120Bowed forearm bones (HP:0003956)1.81855628
121Joint stiffness (HP:0001387)1.81411899
122Femoral bowing (HP:0002980)1.80384576
123Venous insufficiency (HP:0005293)1.79604477
124Thin skin (HP:0000963)1.78015135
125Upper limb amyotrophy (HP:0009129)1.77809812
126Distal upper limb amyotrophy (HP:0007149)1.77809812
127Broad phalanx (HP:0006009)1.77581303
128Increased connective tissue (HP:0009025)1.77555288
129Abnormality of the odontoid process (HP:0003310)1.77100406
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.76877004
131Thoracolumbar scoliosis (HP:0002944)1.76173698
132Ulnar deviation of the wrist (HP:0003049)1.75832312
133Slender build (HP:0001533)1.75129948
134Camptodactyly of toe (HP:0001836)1.73650755
135Increased corneal curvature (HP:0100692)1.72760266
136Keratoconus (HP:0000563)1.72760266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L5.38338826
2DDR25.13089643
3STK244.24668301
4LATS23.78222561
5EPHB23.19688489
6PLK22.92973283
7ERBB32.92419297
8BUB12.56318816
9FLT31.98371456
10PDGFRA1.91932127
11STK31.81600592
12RIPK11.77351940
13PRKD21.62955171
14EIF2AK31.60959472
15CASK1.57206232
16EIF2AK11.57167237
17PAK31.56972575
18BCR1.55944866
19TSSK61.52884218
20FER1.51704231
21PLK31.47531430
22MKNK21.44172174
23MKNK11.41775743
24PIM21.41347183
25KIT1.40079605
26MAP3K61.39791351
27STK381.36953680
28LIMK11.35453630
29AKT31.34168083
30CDK81.33850395
31TRIB31.33609112
32FGFR11.31835136
33LMTK21.31412886
34KSR11.26910896
35TGFBR21.22066891
36LATS11.19842758
37BRSK21.18741129
38NTRK11.14413377
39RPS6KA41.11233775
40PRPF4B1.10887516
41FGFR41.10127072
42PDK21.09843663
43ZAK1.09390558
44EPHB11.07276452
45PAK21.06287552
46MYLK1.03940115
47ROCK11.01836433
48NEK61.00565149
49PKN20.98891519
50PAK40.97437406
51PTK2B0.96880183
52WEE10.96504972
53TRPM70.94810418
54MELK0.93659227
55CDC42BPA0.93405526
56TESK10.93346970
57IRAK30.93326311
58EPHA20.92111918
59PTK20.90020955
60NME10.89264613
61DMPK0.88395988
62DAPK30.88032740
63BRSK10.87815225
64MET0.86867374
65GSK3A0.86254015
66GRK70.84891625
67ICK0.84190352
68PRKCG0.83442138
69TYK20.82360759
70PRKCE0.81700843
71NTRK30.81502647
72EPHA30.80930913
73JAK10.80554499
74NEK90.79906504
75MINK10.79902546
76PRKG20.78565391
77SIK10.77152983
78TGFBR10.75869882
79NME20.74831425
80SIK30.73448642
81TTN0.72972792
82CAMKK20.70569696
83MAP3K30.67278053
84NUAK10.67171384
85ROCK20.66103293
86EIF2AK20.65806066
87PIK3CA0.65554258
88BMPR20.64976080
89MAP2K30.64834482
90MAPKAPK30.63527612
91MST1R0.63229103
92MTOR0.62759657
93CDK180.62510669
94MOS0.61327589
95CDK140.61211948
96WNK10.57005572
97PAK60.56577838
98MAP2K10.55963433
99JAK30.53340859
100CDK150.52441291
101MAP3K120.48321827
102ZAP700.47842869
103PRKCH0.44150463
104TAOK20.43580615
105INSRR0.43136719
106ADRBK10.42971925
107INSR0.42749474
108PDK40.42401687
109PDK30.42401687
110CDK11A0.41775699
111BRAF0.41480384
112PRKD10.41266252
113ILK0.40059079
114PIK3CG0.39189408
115ERBB20.39132451
116PAK10.38970459
117FGFR30.38948115
118PLK10.38835374
119NEK10.37384699
120RPS6KA20.37314933
121TIE10.36606631
122MAPKAPK20.36370421
123ERBB40.35902640
124RET0.35362288
125MAPK70.33878146
126BMX0.31301980
127PRKCI0.30326000
128GRK50.30304783
129ERN10.29968406
130ABL20.29629669
131CAMK2G0.29578395
132MAPK90.29160986
133CLK10.29109832
134SCYL20.28956586
135PRKD30.28918849
136SRC0.28475946
137PRKG10.28433013
138FRK0.27723835
139PDGFRB0.27127707
140IGF1R0.26884395
141PTK60.26774860
142ABL10.26237038
143GRK10.21731135
144DYRK1B0.20568548
145ARAF0.20253934
146CDK90.18258139

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.69485885
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.02134760
3Protein digestion and absorption_Homo sapiens_hsa049743.48971537
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.02295124
5Malaria_Homo sapiens_hsa051442.62858853
6Focal adhesion_Homo sapiens_hsa045102.48146054
7TGF-beta signaling pathway_Homo sapiens_hsa043502.41664640
8Other glycan degradation_Homo sapiens_hsa005112.36381586
9Hedgehog signaling pathway_Homo sapiens_hsa043402.34733280
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.32713997
11Protein export_Homo sapiens_hsa030602.25026619
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09363695
13Basal cell carcinoma_Homo sapiens_hsa052172.08640100
14Dilated cardiomyopathy_Homo sapiens_hsa054141.96750293
15Hippo signaling pathway_Homo sapiens_hsa043901.91540326
16Proteoglycans in cancer_Homo sapiens_hsa052051.87904619
17Amoebiasis_Homo sapiens_hsa051461.85941127
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76848892
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75615983
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75189876
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74083530
22Vibrio cholerae infection_Homo sapiens_hsa051101.68815958
23Complement and coagulation cascades_Homo sapiens_hsa046101.64829743
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60646316
25Proteasome_Homo sapiens_hsa030501.53025315
26Wnt signaling pathway_Homo sapiens_hsa043101.43757477
27Galactose metabolism_Homo sapiens_hsa000521.41704701
28Rheumatoid arthritis_Homo sapiens_hsa053231.39509928
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38075226
30Starch and sucrose metabolism_Homo sapiens_hsa005001.24219789
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22378829
32Melanogenesis_Homo sapiens_hsa049161.21415363
33Lysosome_Homo sapiens_hsa041421.18278694
34Adherens junction_Homo sapiens_hsa045201.18010776
35Arachidonic acid metabolism_Homo sapiens_hsa005901.17316980
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15515820
37Thyroid hormone synthesis_Homo sapiens_hsa049181.12886827
38Phagosome_Homo sapiens_hsa041451.11574030
39MicroRNAs in cancer_Homo sapiens_hsa052061.07225255
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03487121
41Bladder cancer_Homo sapiens_hsa052191.03128107
42Pertussis_Homo sapiens_hsa051331.01645804
43Melanoma_Homo sapiens_hsa052181.01046145
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99590285
45RNA polymerase_Homo sapiens_hsa030200.99362617
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97297653
47Pancreatic cancer_Homo sapiens_hsa052120.94678557
48Prion diseases_Homo sapiens_hsa050200.91715518
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90320815
50Axon guidance_Homo sapiens_hsa043600.90277662
51Cell cycle_Homo sapiens_hsa041100.89525918
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.88882407
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88448522
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.87601210
55Pathways in cancer_Homo sapiens_hsa052000.87458932
56Renin-angiotensin system_Homo sapiens_hsa046140.87458062
57p53 signaling pathway_Homo sapiens_hsa041150.85480938
58Cocaine addiction_Homo sapiens_hsa050300.84634442
59Prostate cancer_Homo sapiens_hsa052150.82295925
60Shigellosis_Homo sapiens_hsa051310.81374339
61Sulfur metabolism_Homo sapiens_hsa009200.80854262
62Small cell lung cancer_Homo sapiens_hsa052220.79940272
63Amphetamine addiction_Homo sapiens_hsa050310.78451361
64Gap junction_Homo sapiens_hsa045400.77400320
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76613027
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.75413394
67N-Glycan biosynthesis_Homo sapiens_hsa005100.70075319
68Sphingolipid metabolism_Homo sapiens_hsa006000.66567248
69Endocytosis_Homo sapiens_hsa041440.64907853
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63801206
71Circadian entrainment_Homo sapiens_hsa047130.60540782
72African trypanosomiasis_Homo sapiens_hsa051430.59614095
73Toxoplasmosis_Homo sapiens_hsa051450.59404510
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58781993
75HIF-1 signaling pathway_Homo sapiens_hsa040660.57633650
76TNF signaling pathway_Homo sapiens_hsa046680.57295302
77Chronic myeloid leukemia_Homo sapiens_hsa052200.54336634
78RNA transport_Homo sapiens_hsa030130.53782611
79Oxidative phosphorylation_Homo sapiens_hsa001900.52965031
80Thyroid cancer_Homo sapiens_hsa052160.52286629
81Rap1 signaling pathway_Homo sapiens_hsa040150.52074418
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52016172
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51837735
84Estrogen signaling pathway_Homo sapiens_hsa049150.51604760
85HTLV-I infection_Homo sapiens_hsa051660.51600653
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51160825
87Legionellosis_Homo sapiens_hsa051340.50615056
88Nicotine addiction_Homo sapiens_hsa050330.50458444
89GABAergic synapse_Homo sapiens_hsa047270.50156944
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49794176
91Colorectal cancer_Homo sapiens_hsa052100.49733879
92Hepatitis B_Homo sapiens_hsa051610.49688029
93Synaptic vesicle cycle_Homo sapiens_hsa047210.49676082
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48144835
95Parkinsons disease_Homo sapiens_hsa050120.47915612
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47605648
97Glioma_Homo sapiens_hsa052140.47245359
98Salmonella infection_Homo sapiens_hsa051320.46537500
99Serotonergic synapse_Homo sapiens_hsa047260.46257287
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45561604
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44149948
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43832311
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42892210
104Dopaminergic synapse_Homo sapiens_hsa047280.42856232
105Ras signaling pathway_Homo sapiens_hsa040140.41673496
106Long-term depression_Homo sapiens_hsa047300.41473636
107Oocyte meiosis_Homo sapiens_hsa041140.40164226
108Vitamin B6 metabolism_Homo sapiens_hsa007500.39565496
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.39190844
110Tight junction_Homo sapiens_hsa045300.39044522
111Purine metabolism_Homo sapiens_hsa002300.38867839
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37674427
113Huntingtons disease_Homo sapiens_hsa050160.36925812
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36121941
115Notch signaling pathway_Homo sapiens_hsa043300.36080275
116Hepatitis C_Homo sapiens_hsa051600.35743494
117Ovarian steroidogenesis_Homo sapiens_hsa049130.35165857
118ErbB signaling pathway_Homo sapiens_hsa040120.34964515
119Cholinergic synapse_Homo sapiens_hsa047250.33909961
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33728719
121Platelet activation_Homo sapiens_hsa046110.32586322
122Renal cell carcinoma_Homo sapiens_hsa052110.32444105
123Collecting duct acid secretion_Homo sapiens_hsa049660.32181605
124Cardiac muscle contraction_Homo sapiens_hsa042600.31453251
125MAPK signaling pathway_Homo sapiens_hsa040100.31404404
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31167051
127Mineral absorption_Homo sapiens_hsa049780.31086695
128Arginine and proline metabolism_Homo sapiens_hsa003300.30686978
129Insulin resistance_Homo sapiens_hsa049310.30646935
130Circadian rhythm_Homo sapiens_hsa047100.30389425
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.30308987
132Apoptosis_Homo sapiens_hsa042100.29403142
133Endometrial cancer_Homo sapiens_hsa052130.28877721
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28874043
135Glutathione metabolism_Homo sapiens_hsa004800.28372071
136mTOR signaling pathway_Homo sapiens_hsa041500.27939120
137VEGF signaling pathway_Homo sapiens_hsa043700.25621449
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.25224314

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