CTIF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.91695318
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.80054891
3locomotory exploration behavior (GO:0035641)4.76465937
4vocalization behavior (GO:0071625)4.57532165
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49042617
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.31949365
7glutamate secretion (GO:0014047)4.28155071
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09136225
9neuron cell-cell adhesion (GO:0007158)4.02760577
10regulation of synaptic vesicle exocytosis (GO:2000300)4.01004147
11synaptic vesicle exocytosis (GO:0016079)3.99911552
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.92083881
13regulation of glutamate receptor signaling pathway (GO:1900449)3.86624384
14layer formation in cerebral cortex (GO:0021819)3.80898466
15gamma-aminobutyric acid transport (GO:0015812)3.76530063
16proline transport (GO:0015824)3.71503374
17exploration behavior (GO:0035640)3.68994830
18protein localization to synapse (GO:0035418)3.65879640
19neurotransmitter secretion (GO:0007269)3.63483991
20regulation of synaptic vesicle transport (GO:1902803)3.53438812
21response to pheromone (GO:0019236)3.50701774
22dendritic spine morphogenesis (GO:0060997)3.44275264
23regulation of neuronal synaptic plasticity (GO:0048168)3.36649405
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34204145
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.33190314
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.32728903
27cell migration in hindbrain (GO:0021535)3.32513545
28cerebellar granule cell differentiation (GO:0021707)3.32011604
29neurotransmitter-gated ion channel clustering (GO:0072578)3.30496381
30synaptic vesicle endocytosis (GO:0048488)3.29403498
31protein heterotrimerization (GO:0070208)3.28593499
32dendrite morphogenesis (GO:0048813)3.27874075
33regulation of synapse structural plasticity (GO:0051823)3.23770515
34axonal fasciculation (GO:0007413)3.18690911
35neuron recognition (GO:0008038)3.17695652
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14513471
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11747521
38pyrimidine nucleobase catabolic process (GO:0006208)3.09905213
39glycine transport (GO:0015816)3.07866213
40activation of protein kinase A activity (GO:0034199)3.04963401
41cerebellar Purkinje cell differentiation (GO:0021702)3.01850672
42synaptic transmission, glutamatergic (GO:0035249)2.98803211
43postsynaptic membrane organization (GO:0001941)2.98279409
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98022993
45neurotransmitter transport (GO:0006836)2.96034452
46neuronal action potential propagation (GO:0019227)2.94510894
47cell communication by electrical coupling (GO:0010644)2.89714803
48alanine transport (GO:0032328)2.88402853
49innervation (GO:0060384)2.86258130
50glutamate receptor signaling pathway (GO:0007215)2.86218142
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84004717
52neuromuscular process controlling posture (GO:0050884)2.82182334
53cellular potassium ion homeostasis (GO:0030007)2.81296510
54neuron-neuron synaptic transmission (GO:0007270)2.81237380
55sodium ion export (GO:0071436)2.78429820
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76016269
57neuromuscular process controlling balance (GO:0050885)2.75071157
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73999687
59regulation of neurotransmitter levels (GO:0001505)2.73482596
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72698100
61amino acid import (GO:0043090)2.72508837
62positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70985562
63central nervous system projection neuron axonogenesis (GO:0021952)2.70981521
64positive regulation of membrane potential (GO:0045838)2.69900021
65neuronal ion channel clustering (GO:0045161)2.69668883
66presynaptic membrane assembly (GO:0097105)2.69387888
67regulation of postsynaptic membrane potential (GO:0060078)2.69251330
68positive regulation of dendritic spine development (GO:0060999)2.66904616
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66712262
70response to auditory stimulus (GO:0010996)2.64617219
71nucleobase catabolic process (GO:0046113)2.64553693
72regulation of neurotransmitter secretion (GO:0046928)2.63251020
73membrane depolarization during action potential (GO:0086010)2.63022917
74regulation of dendritic spine morphogenesis (GO:0061001)2.61610620
75presynaptic membrane organization (GO:0097090)2.61204887
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60877456
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60576039
78long-term memory (GO:0007616)2.59892648
79cellular response to monoamine stimulus (GO:0071868)2.59711640
80cellular response to catecholamine stimulus (GO:0071870)2.59711640
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59556557
82regulation of synaptic plasticity (GO:0048167)2.58797513
83regulation of synapse maturation (GO:0090128)2.57206941
84protein targeting to plasma membrane (GO:0072661)2.57155516
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56145372
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.56098372
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56025542
88L-amino acid import (GO:0043092)2.55761842
89establishment of nucleus localization (GO:0040023)2.54065775
90collagen fibril organization (GO:0030199)2.53393104
91regulation of ARF protein signal transduction (GO:0032012)2.53301562
92regulation of axon extension involved in axon guidance (GO:0048841)2.52274369
93neuron projection extension (GO:1990138)2.51857989
94membrane hyperpolarization (GO:0060081)2.51505449
95auditory behavior (GO:0031223)2.51292654
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49759204
97synapse assembly (GO:0007416)2.48397977
98organelle transport along microtubule (GO:0072384)2.48363278
99cerebellar Purkinje cell layer development (GO:0021680)2.46129607
100neuromuscular process (GO:0050905)2.46055666
101vesicle transport along microtubule (GO:0047496)2.45722512
102intraspecies interaction between organisms (GO:0051703)2.45523741
103social behavior (GO:0035176)2.45523741
104positive regulation of synapse maturation (GO:0090129)2.45492905
105mating behavior (GO:0007617)2.45447627
106positive regulation of axon extension (GO:0045773)2.44931671
107extracellular matrix assembly (GO:0085029)2.44250523
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43712568
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43706203
110myelination in peripheral nervous system (GO:0022011)2.43691342
111peripheral nervous system axon ensheathment (GO:0032292)2.43691342
112transmission of nerve impulse (GO:0019226)2.43526649
113synapse organization (GO:0050808)2.42891891
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42209646
115positive regulation of fibroblast migration (GO:0010763)2.40600754
116membrane depolarization (GO:0051899)2.40597980
117axon extension (GO:0048675)2.40186686
118regulation of neurotransmitter transport (GO:0051588)2.40113031
119prepulse inhibition (GO:0060134)2.39372224
120cell communication involved in cardiac conduction (GO:0086065)2.37006864
121axon cargo transport (GO:0008088)2.36847675
122dendritic spine organization (GO:0097061)2.36051920
123adherens junction assembly (GO:0034333)2.33890487
124negative regulation of catenin import into nucleus (GO:0035414)2.33597537
125semaphorin-plexin signaling pathway (GO:0071526)2.32873498
126kidney mesenchyme development (GO:0072074)2.32120079
127potassium ion homeostasis (GO:0055075)2.31812393
128membrane assembly (GO:0071709)2.31462369
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.30064324
130positive regulation of dendrite development (GO:1900006)2.29631980
131metanephric mesenchyme development (GO:0072075)2.29447789
132cell migration involved in heart development (GO:0060973)2.25439317
133regulation of axon guidance (GO:1902667)2.24227270
134barbed-end actin filament capping (GO:0051016)2.23826850
135cellular sodium ion homeostasis (GO:0006883)2.23029549
136cell-substrate junction assembly (GO:0007044)2.22921976
137skin morphogenesis (GO:0043589)2.22475115
138dopamine receptor signaling pathway (GO:0007212)2.22474610
139regulation of glycogen (starch) synthase activity (GO:2000465)2.20872298
140cellular response to epinephrine stimulus (GO:0071872)2.20357917
141response to dietary excess (GO:0002021)2.19664750
142positive regulation of synapse assembly (GO:0051965)2.18306489
143endodermal cell differentiation (GO:0035987)2.18129282
144negative regulation of dendrite morphogenesis (GO:0050774)2.17290827
145cell-substrate adherens junction assembly (GO:0007045)2.16799073
146focal adhesion assembly (GO:0048041)2.16799073
147regulation of vesicle fusion (GO:0031338)2.15902255
148developmental cell growth (GO:0048588)2.15523994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59452517
2GBX2_23144817_ChIP-Seq_PC3_Human2.97184273
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.89898595
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73481225
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71952881
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60835986
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52714170
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52714170
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38954873
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38621242
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34166498
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30921860
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28042618
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28014648
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.25905820
16DROSHA_22980978_ChIP-Seq_HELA_Human2.24844253
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23428262
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23289308
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20950237
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.12120142
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.10503105
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.02362204
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02313434
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97561156
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.79375470
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.78815632
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73976045
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71030950
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70865235
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.70836200
31AR_21572438_ChIP-Seq_LNCaP_Human1.69284339
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.68270296
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66592528
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63348971
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57016253
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54452649
37LXR_22292898_ChIP-Seq_THP-1_Human1.53424579
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.51803057
39SMAD4_21799915_ChIP-Seq_A2780_Human1.49557094
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45141371
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44865237
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44460904
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42882919
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42000567
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40006883
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34830738
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34217800
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33435440
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32044074
50TET1_21490601_ChIP-Seq_MESCs_Mouse1.29425056
51CLOCK_20551151_ChIP-Seq_293T_Human1.29316202
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27928140
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26577590
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.26457685
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.25495066
56TAF15_26573619_Chip-Seq_HEK293_Human1.25485256
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24817091
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24785211
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.24585726
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24272825
61CTCF_27219007_Chip-Seq_Bcells_Human1.24148983
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23941244
63AR_19668381_ChIP-Seq_PC3_Human1.22824640
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21690783
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20834348
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.18952265
67P300_19829295_ChIP-Seq_ESCs_Human1.18598068
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17385405
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16877664
70KDM2B_26808549_Chip-Seq_K562_Human1.16804448
71STAT3_23295773_ChIP-Seq_U87_Human1.16488114
72AHR_22903824_ChIP-Seq_MCF-7_Human1.16477714
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15913156
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14823166
75TP53_23651856_ChIP-Seq_MEFs_Mouse1.14640720
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.12503743
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12446167
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.12289824
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.11505608
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10694353
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10655542
82AR_25329375_ChIP-Seq_VCAP_Human1.10263368
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08502013
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08316452
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07789199
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07305809
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.07219180
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05483048
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.04874641
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04824611
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04594256
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04348975
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04079766
94KDM2B_26808549_Chip-Seq_DND41_Human1.03947844
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03516108
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02186197
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01098159
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00794206
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.00625478
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.00625478
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00092132
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00079852
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99738123
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98299118
105IGF1R_20145208_ChIP-Seq_DFB_Human0.97407753
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97250718
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.97099538
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96975802
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96672647
110KDM2B_26808549_Chip-Seq_JURKAT_Human0.96309389
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95835253
112TCF4_23295773_ChIP-Seq_U87_Human0.95530637
113* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95272827
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94907696
115ZNF274_21170338_ChIP-Seq_K562_Hela0.94417381
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93922740
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93650957
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93593299
119BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92788114
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.92189450
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.92064169
122* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91448658
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90744686
124RUNX2_22187159_ChIP-Seq_PCA_Human0.90168746
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89748281
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89595304
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89526195
128RACK7_27058665_Chip-Seq_MCF-7_Human0.89288301
129RXR_22108803_ChIP-Seq_LS180_Human0.89189036
130TP53_16413492_ChIP-PET_HCT116_Human0.88330222
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88088606
132BCAT_22108803_ChIP-Seq_LS180_Human0.87915450
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87869161
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.87049557
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86800081
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86770590
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.86199904
138TP53_18474530_ChIP-ChIP_U2OS_Human0.85705242
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85375696
140SMC4_20622854_ChIP-Seq_HELA_Human0.84829377
141SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84083613
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83767417
143TP53_22127205_ChIP-Seq_IMR90_Human0.83403056
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.82885987
145WT1_19549856_ChIP-ChIP_CCG9911_Human0.82308034
146CREB1_26743006_Chip-Seq_LNCaP_Human0.81999069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48525360
2MP0008438_abnormal_cutaneous_collagen4.64454179
3MP0003880_abnormal_central_pattern3.57574440
4MP0004270_analgesia3.51438047
5MP0003635_abnormal_synaptic_transmissio3.45854389
6MP0003705_abnormal_hypodermis_morpholog3.27689773
7MP0005503_abnormal_tendon_morphology2.86231060
8MP0001968_abnormal_touch/_nociception2.85807674
9MP0002063_abnormal_learning/memory/cond2.76710177
10MP0009745_abnormal_behavioral_response2.74679859
11MP0005423_abnormal_somatic_nervous2.71394369
12MP0005275_abnormal_skin_tensile2.62585859
13MP0003279_aneurysm2.60572295
14MP0001958_emphysema2.60099333
15MP0002064_seizures2.55206717
16MP0002734_abnormal_mechanical_nocicepti2.51730358
17MP0009046_muscle_twitch2.44674147
18MP0009780_abnormal_chondrocyte_physiolo2.32366911
19MP0002735_abnormal_chemical_nociception2.32070083
20MP0002572_abnormal_emotion/affect_behav2.31963131
21MP0001486_abnormal_startle_reflex2.24175896
22MP0004858_abnormal_nervous_system2.19174715
23MP0004272_abnormal_basement_membrane2.16963677
24MP0002733_abnormal_thermal_nociception2.14983410
25MP0006276_abnormal_autonomic_nervous2.13673289
26MP0002272_abnormal_nervous_system2.04436131
27MP0002736_abnormal_nociception_after2.02084929
28MP0000778_abnormal_nervous_system1.97925776
29MP0005257_abnormal_intraocular_pressure1.91111485
30MP0001970_abnormal_pain_threshold1.86422949
31MP0001501_abnormal_sleep_pattern1.85436588
32MP0002822_catalepsy1.79333458
33MP0002184_abnormal_innervation1.77381681
34MP0002067_abnormal_sensory_capabilities1.70387321
35MP0001440_abnormal_grooming_behavior1.70044283
36MP0004811_abnormal_neuron_physiology1.67136639
37MP0003329_amyloid_beta_deposits1.66597987
38MP0010368_abnormal_lymphatic_system1.66141346
39MP0005670_abnormal_white_adipose1.62131936
40MP0001984_abnormal_olfaction1.59494448
41MP0002557_abnormal_social/conspecific_i1.57874270
42MP0002909_abnormal_adrenal_gland1.57430309
43MP0000955_abnormal_spinal_cord1.55698221
44MP0005646_abnormal_pituitary_gland1.55695989
45MP0003122_maternal_imprinting1.49723262
46MP0004924_abnormal_behavior1.49689545
47MP0005386_behavior/neurological_phenoty1.49689545
48MP0000569_abnormal_digit_pigmentation1.49456450
49MP0003566_abnormal_cell_adhesion1.48666718
50MP0005645_abnormal_hypothalamus_physiol1.48139079
51MP0005409_darkened_coat_color1.47823350
52MP0002837_dystrophic_cardiac_calcinosis1.43750830
53MP0002139_abnormal_hepatobiliary_system1.43748044
54MP0008569_lethality_at_weaning1.43312543
55MP0004885_abnormal_endolymph1.37722819
56MP0001348_abnormal_lacrimal_gland1.35788607
57MP0002882_abnormal_neuron_morphology1.35479265
58MP0002295_abnormal_pulmonary_circulatio1.34073640
59MP0005551_abnormal_eye_electrophysiolog1.30085023
60MP0000751_myopathy1.26249442
61MP0002066_abnormal_motor_capabilities/c1.25912901
62MP0009384_cardiac_valve_regurgitation1.25558122
63MP0003787_abnormal_imprinting1.25031949
64MP0003633_abnormal_nervous_system1.24374837
65MP0002108_abnormal_muscle_morphology1.23519687
66MP0001502_abnormal_circadian_rhythm1.19577153
67MP0003091_abnormal_cell_migration1.18403526
68MP0000003_abnormal_adipose_tissue1.17333800
69MP0003879_abnormal_hair_cell1.15334060
70MP0005508_abnormal_skeleton_morphology1.15246827
71MP0005085_abnormal_gallbladder_physiolo1.14304587
72MP0000767_abnormal_smooth_muscle1.13501810
73MP0005365_abnormal_bile_salt1.12687759
74MP0005375_adipose_tissue_phenotype1.06946502
75MP0001299_abnormal_eye_distance/1.05182215
76MP0002896_abnormal_bone_mineralization1.05046400
77MP0003690_abnormal_glial_cell1.03569913
78MP0001177_atelectasis1.03569900
79MP0005595_abnormal_vascular_smooth1.02404289
80MP0003631_nervous_system_phenotype1.02005947
81MP0001542_abnormal_bone_strength1.01941245
82MP0008961_abnormal_basal_metabolism1.01540402
83MP0005360_urolithiasis1.01042029
84MP0005666_abnormal_adipose_tissue0.98643147
85MP0003252_abnormal_bile_duct0.98443029
86MP0004130_abnormal_muscle_cell0.97781876
87MP0002152_abnormal_brain_morphology0.97139008
88MP0002069_abnormal_eating/drinking_beha0.94824797
89MP0005535_abnormal_body_temperature0.94802735
90MP0003634_abnormal_glial_cell0.92874483
91MP0006138_congestive_heart_failure0.92793420
92MP0002229_neurodegeneration0.92155808
93MP0000759_abnormal_skeletal_muscle0.92155805
94MP0003283_abnormal_digestive_organ0.91627345
95MP0002090_abnormal_vision0.90942064
96MP0004142_abnormal_muscle_tone0.90205017
97MP0002089_abnormal_postnatal_growth/wei0.89899277
98MP0005023_abnormal_wound_healing0.88419652
99MP0002249_abnormal_larynx_morphology0.88157083
100MP0005623_abnormal_meninges_morphology0.87467416
101MP0004085_abnormal_heartbeat0.85671934
102MP0005187_abnormal_penis_morphology0.84651043
103MP0000604_amyloidosis0.84456607
104MP0003942_abnormal_urinary_system0.83357163
105MP0003385_abnormal_body_wall0.82700356
106MP0008874_decreased_physiological_sensi0.82286789
107MP0001905_abnormal_dopamine_level0.80506058
108MP0010329_abnormal_lipoprotein_level0.79804064
109MP0002971_abnormal_brown_adipose0.79445447
110MP0000747_muscle_weakness0.79009896
111MP0009250_abnormal_appendicular_skeleto0.78959535
112MP0002060_abnormal_skin_morphology0.78656257
113MP0004087_abnormal_muscle_fiber0.78238365
114MP0000013_abnormal_adipose_tissue0.77753534
115MP0003075_altered_response_to0.77456066
116MP0003045_fibrosis0.76915818
117MP0004145_abnormal_muscle_electrophysio0.76534438
118MP0002752_abnormal_somatic_nervous0.75967605
119MP0000749_muscle_degeneration0.75880438
120MP0003632_abnormal_nervous_system0.74137993
121MP0008872_abnormal_physiological_respon0.74041217
122MP0001849_ear_inflammation0.73373376
123MP0002133_abnormal_respiratory_system0.72827130
124MP0005388_respiratory_system_phenotype0.72827130
125MP0000733_abnormal_muscle_development0.72724744
126MP0000462_abnormal_digestive_system0.72255384
127MP0003172_abnormal_lysosome_physiology0.71318168
128MP0005248_abnormal_Harderian_gland0.71070468
129MP0003137_abnormal_impulse_conducting0.70813321
130MP0008875_abnormal_xenobiotic_pharmacok0.69409519
131MP0000920_abnormal_myelination0.68694581
132MP0002876_abnormal_thyroid_physiology0.67385212
133MP0003950_abnormal_plasma_membrane0.67017447
134MP0003868_abnormal_feces_composition0.66114364
135MP0005620_abnormal_muscle_contractility0.65083176
136MP0005394_taste/olfaction_phenotype0.64047932
137MP0005499_abnormal_olfactory_system0.64047932
138MP0000631_abnormal_neuroendocrine_gland0.63867376
139MP0010386_abnormal_urinary_bladder0.62618685
140MP0005448_abnormal_energy_balance0.62070547
141MP0004233_abnormal_muscle_weight0.61614806
142MP0002638_abnormal_pupillary_reflex0.59912241
143MP0001529_abnormal_vocalization0.58559050
144MP0000639_abnormal_adrenal_gland0.57349262
145MP0000534_abnormal_ureter_morphology0.56144956

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.33419698
2Myokymia (HP:0002411)5.28968757
3Focal motor seizures (HP:0011153)5.07713814
4Premature rupture of membranes (HP:0001788)4.92539758
5Focal seizures (HP:0007359)4.39810338
6Progressive cerebellar ataxia (HP:0002073)4.18801420
7Febrile seizures (HP:0002373)3.75926384
8Action tremor (HP:0002345)3.75037286
9Epileptic encephalopathy (HP:0200134)3.48819318
10Visual hallucinations (HP:0002367)3.45236142
11Supranuclear gaze palsy (HP:0000605)3.41582671
12Shallow orbits (HP:0000586)3.38233740
13Vascular tortuosity (HP:0004948)3.34515016
14Aortic aneurysm (HP:0004942)3.21126036
15Aortic dissection (HP:0002647)3.16930347
16Atonic seizures (HP:0010819)3.12842678
17Atrophic scars (HP:0001075)3.11985574
18Bladder diverticulum (HP:0000015)3.10633652
19Cerebral aneurysm (HP:0004944)3.05012430
20Arterial tortuosity (HP:0005116)3.00903214
21Generalized tonic-clonic seizures (HP:0002069)2.98590416
22Ankle clonus (HP:0011448)2.94584226
23Abnormal eating behavior (HP:0100738)2.93047475
24Absence seizures (HP:0002121)2.91833976
25Genetic anticipation (HP:0003743)2.89895845
26Urinary bladder sphincter dysfunction (HP:0002839)2.89834814
27Broad metatarsal (HP:0001783)2.87088282
28Wormian bones (HP:0002645)2.80990510
29Insidious onset (HP:0003587)2.80966331
30Termporal pattern (HP:0011008)2.80966331
31Torticollis (HP:0000473)2.78906874
32Spinal rigidity (HP:0003306)2.78759521
33Hyperventilation (HP:0002883)2.76619858
34Type 1 muscle fiber predominance (HP:0003803)2.75739909
35Soft skin (HP:0000977)2.71918631
36Impaired vibration sensation in the lower limbs (HP:0002166)2.69630164
37Fragile skin (HP:0001030)2.68451917
38Ankle contracture (HP:0006466)2.67999640
39Abnormality of the lower motor neuron (HP:0002366)2.66638813
40Increased variability in muscle fiber diameter (HP:0003557)2.64714145
41Poor eye contact (HP:0000817)2.63513430
42Abnormal social behavior (HP:0012433)2.61910501
43Impaired social interactions (HP:0000735)2.61910501
44Dialeptic seizures (HP:0011146)2.61467567
45Neonatal short-limb short stature (HP:0008921)2.60877248
46Polyphagia (HP:0002591)2.59012228
47Truncal ataxia (HP:0002078)2.56052178
48Dysdiadochokinesis (HP:0002075)2.56031358
49Depression (HP:0000716)2.53589568
50Agitation (HP:0000713)2.52443112
51Bowel diverticulosis (HP:0005222)2.52398970
52Postural instability (HP:0002172)2.51902150
53Overgrowth (HP:0001548)2.50823851
54Broad-based gait (HP:0002136)2.48372279
55Excessive salivation (HP:0003781)2.47396011
56Drooling (HP:0002307)2.47396011
57Abnormality of the corticospinal tract (HP:0002492)2.47252231
58Genu recurvatum (HP:0002816)2.46628131
59Abnormality of dentin (HP:0010299)2.45604980
60Mutism (HP:0002300)2.42629650
61Gaze-evoked nystagmus (HP:0000640)2.41210628
62Neurofibrillary tangles (HP:0002185)2.38921191
63Mitral regurgitation (HP:0001653)2.36996022
64Urinary urgency (HP:0000012)2.36152144
65Pheochromocytoma (HP:0002666)2.36092105
66Focal dystonia (HP:0004373)2.36068580
67Fetal akinesia sequence (HP:0001989)2.33549606
68Dysmetria (HP:0001310)2.33146644
69Mitral valve prolapse (HP:0001634)2.33125758
70Cerebral inclusion bodies (HP:0100314)2.29106652
71Hyperextensible skin (HP:0000974)2.28546425
72Anxiety (HP:0000739)2.28443589
73Cervical subluxation (HP:0003308)2.26984371
74Craniofacial dystonia (HP:0012179)2.26471832
75Amblyopia (HP:0000646)2.24793481
76Spastic gait (HP:0002064)2.24713196
77Ulnar bowing (HP:0003031)2.23162228
78Hyperacusis (HP:0010780)2.22347155
79Upper limb amyotrophy (HP:0009129)2.21331440
80Distal upper limb amyotrophy (HP:0007149)2.21331440
81Dilatation of the ascending aorta (HP:0005111)2.20624301
82Lower limb muscle weakness (HP:0007340)2.18300676
83Mildly elevated creatine phosphokinase (HP:0008180)2.17494736
84Abnormality of binocular vision (HP:0011514)2.16795852
85Diplopia (HP:0000651)2.16795852
86Follicular hyperkeratosis (HP:0007502)2.14810452
87Papilledema (HP:0001085)2.13751673
88EEG with generalized epileptiform discharges (HP:0011198)2.13093811
89Epileptiform EEG discharges (HP:0011182)2.12835852
90Wide anterior fontanel (HP:0000260)2.12776764
91Blue irides (HP:0000635)2.12456676
92Mild short stature (HP:0003502)2.12006479
93Deep venous thrombosis (HP:0002625)2.11985847
94Hypsarrhythmia (HP:0002521)2.10281618
95Scanning speech (HP:0002168)2.09558628
96Abnormality of skeletal muscle fiber size (HP:0012084)2.09456861
97Status epilepticus (HP:0002133)2.08523122
98Postural tremor (HP:0002174)2.08380967
99Turricephaly (HP:0000262)2.07903615
100Increased connective tissue (HP:0009025)2.06719696
101Intention tremor (HP:0002080)2.05563002
102Blue sclerae (HP:0000592)2.04917106
103Limb dystonia (HP:0002451)2.04276662
104Hypoventilation (HP:0002791)2.01209163
105Hemiplegia (HP:0002301)2.00170917
106Aneurysm (HP:0002617)1.99407650
107Slender build (HP:0001533)1.99255653
108Biconcave vertebral bodies (HP:0004586)1.95381543
109Megalencephaly (HP:0001355)1.92971821
110Insomnia (HP:0100785)1.92677484
111Wrist flexion contracture (HP:0001239)1.91974862
112Coronal craniosynostosis (HP:0004440)1.91090924
113Peritonitis (HP:0002586)1.90371867
114Hypoplasia of the iris (HP:0007676)1.90165889
115Joint laxity (HP:0001388)1.89425377
116Infantile muscular hypotonia (HP:0008947)1.88576924
117Absent speech (HP:0001344)1.88186512
118Vertebral compression fractures (HP:0002953)1.87069372
119Lower limb amyotrophy (HP:0007210)1.86353199
120Stereotypic behavior (HP:0000733)1.83954941
121Macroorchidism (HP:0000053)1.83683110
122Akinesia (HP:0002304)1.83449421
123Hammertoe (HP:0001765)1.83360052
124Annular pancreas (HP:0001734)1.82662395
125Neuroendocrine neoplasm (HP:0100634)1.82579313
126Bradykinesia (HP:0002067)1.82481587
127Impaired vibratory sensation (HP:0002495)1.82017101
128Aortic regurgitation (HP:0001659)1.81716580
129Dysmetric saccades (HP:0000641)1.81583046
130Hypercortisolism (HP:0001578)1.80162352
131Morphological abnormality of the pyramidal tract (HP:0002062)1.78662280
132Hand muscle atrophy (HP:0009130)1.76504948
133Mitral stenosis (HP:0001718)1.76240385
134Hemiparesis (HP:0001269)1.75925426
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75761863
136Ectopia lentis (HP:0001083)1.74830380
137Aqueductal stenosis (HP:0002410)1.74221051
138Elfin facies (HP:0004428)1.73886548
139Ventricular fibrillation (HP:0001663)1.73495238
140Central scotoma (HP:0000603)1.73247434
141Distal lower limb amyotrophy (HP:0008944)1.71634470
142Abnormality of ocular smooth pursuit (HP:0000617)1.70186185
143Disproportionate tall stature (HP:0001519)1.70052996
144Round ear (HP:0100830)1.69817953
145Obstructive sleep apnea (HP:0002870)1.69638234
146Aplasia involving bones of the upper limbs (HP:0009823)1.68115611
147Aplasia of the phalanges of the hand (HP:0009802)1.68115611
148Aplasia involving bones of the extremities (HP:0009825)1.68115611
149Abnormality of pain sensation (HP:0010832)1.67887680
150Impaired pain sensation (HP:0007328)1.67887680
151Spondylolisthesis (HP:0003302)1.67494405
152Limited hip movement (HP:0008800)1.67079814
153Hepatoblastoma (HP:0002884)1.66568635
154Bronchomalacia (HP:0002780)1.65708484
155Prolonged QT interval (HP:0001657)1.63743482
156Renal duplication (HP:0000075)1.63349321
157Bradycardia (HP:0001662)1.63345853
158Sleep apnea (HP:0010535)1.63167085
159Pointed chin (HP:0000307)1.62351090
160Impaired smooth pursuit (HP:0007772)1.61926333
161Open mouth (HP:0000194)1.61900543
162Achilles tendon contracture (HP:0001771)1.61356152
163Clonus (HP:0002169)1.61156142
164Failure to thrive in infancy (HP:0001531)1.60998331
165Abnormality of salivation (HP:0100755)1.60751446
166Lymphangioma (HP:0100764)1.59836688
167Hyporeflexia of lower limbs (HP:0002600)1.59129989
168Neoplasm of the heart (HP:0100544)1.58858193
169Broad face (HP:0000283)1.56172942
170Muscle fiber splitting (HP:0003555)1.54945423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.75231465
2MARK13.62827442
3MAP3K93.20603297
4MAP3K43.07733092
5EPHA42.72288297
6PAK62.63998093
7MINK12.48103705
8MAP2K72.29328385
9MAP2K42.12773290
10NTRK12.07852846
11LATS22.04747570
12NTRK22.01667096
13DAPK21.95982441
14PRKD31.81004500
15MYLK1.69369194
16KSR21.62844831
17TTN1.57698486
18SIK21.55750132
19CAMKK11.52243439
20PHKG21.49849829
21PHKG11.49849829
22CASK1.45647231
23STK381.43949141
24MAPK131.37785323
25CAMK1G1.37571088
26ARAF1.35935516
27CDK51.34885030
28GRK51.33077641
29PLK21.25024636
30RET1.24914783
31KSR11.23701617
32EEF2K1.22054189
33MAP3K121.20774824
34TESK11.17391583
35PAK21.14903067
36SGK4941.14226803
37SGK2231.14226803
38PRKCH1.12105243
39TYRO31.10587633
40LMTK21.10232770
41UHMK11.08944533
42PAK31.07410417
43SGK21.04175777
44MAP3K21.03002898
45PRPF4B1.02965911
46PRKCG1.02636748
47RIPK11.02591923
48SGK31.02218156
49PRKD20.96691925
50SIK10.96419508
51INSRR0.95345382
52LIMK10.89239146
53SIK30.89094749
54STK110.88589650
55PDGFRB0.88393213
56FGFR20.85690135
57DDR20.84452855
58TNIK0.83235484
59ROCK20.82497957
60CAMK2A0.81469161
61PINK10.79397789
62TAOK10.77933643
63MARK20.76973935
64MOS0.76721256
65CAMK10.76144849
66CSNK1G20.76073207
67CAMK1D0.74457999
68MTOR0.74146188
69PNCK0.73793002
70PDGFRA0.73470437
71PRKCZ0.73078735
72DAPK10.72429462
73ICK0.71625171
74WNK10.70796083
75DAPK30.69867619
76FER0.69196673
77CDK140.67817608
78TRIB30.67045412
79PKN20.67023237
80CDK180.66612494
81CDC42BPA0.65796803
82FES0.65749594
83SGK10.65440088
84CDK150.64612376
85RIPK40.63647356
86ERN10.62024988
87MAP3K70.60693796
88RPS6KA20.59713863
89MAPK40.59249078
90PRKG20.57271426
91ALK0.57230601
92EPHB20.57040448
93ABL20.56861979
94AKT30.56846984
95PKN10.56568002
96MAP2K10.54511015
97PRKCE0.54096554
98MAP3K60.53812175
99MAPK70.53774928
100DMPK0.53633472
101CAMK40.53109359
102BMX0.52928629
103PDPK10.52581163
104CDK11A0.51991978
105ROCK10.51329504
106RPS6KA30.50753450
107PRKD10.50598280
108MAP3K10.50490906
109PTK2B0.49821849
110CAMK2D0.47982186
111NEK90.47842390
112ERBB20.47527142
113MAP3K130.47391881
114TGFBR20.46628035
115TIE10.46150117
116MAPK100.46061863
117PDK10.45692878
118EPHB10.44194809
119CAMK2G0.43303056
120DYRK1A0.43286717
121LATS10.42640428
122MAPK120.42617300
123CAMK2B0.42444603
124PTK20.42343329
125CAMKK20.42131086
126FYN0.41204385

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.63810763
2Nicotine addiction_Homo sapiens_hsa050332.60581789
3Synaptic vesicle cycle_Homo sapiens_hsa047212.58197691
4GABAergic synapse_Homo sapiens_hsa047272.20918905
5Circadian entrainment_Homo sapiens_hsa047132.03210038
6Olfactory transduction_Homo sapiens_hsa047401.97243976
7Glutamatergic synapse_Homo sapiens_hsa047241.94918249
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94555978
9ECM-receptor interaction_Homo sapiens_hsa045121.87012672
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84151234
11Morphine addiction_Homo sapiens_hsa050321.81093135
12Insulin secretion_Homo sapiens_hsa049111.71093125
13Long-term potentiation_Homo sapiens_hsa047201.70325297
14Dopaminergic synapse_Homo sapiens_hsa047281.66500048
15Amphetamine addiction_Homo sapiens_hsa050311.62786642
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56957191
17Cholinergic synapse_Homo sapiens_hsa047251.56314688
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55704557
19Salivary secretion_Homo sapiens_hsa049701.55367183
20Phototransduction_Homo sapiens_hsa047441.52320420
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49989454
22Focal adhesion_Homo sapiens_hsa045101.47305231
23Arginine biosynthesis_Homo sapiens_hsa002201.46765628
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46312108
25Taste transduction_Homo sapiens_hsa047421.39206627
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36863933
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33909343
28Gastric acid secretion_Homo sapiens_hsa049711.32912750
29Cocaine addiction_Homo sapiens_hsa050301.32487418
30Type II diabetes mellitus_Homo sapiens_hsa049301.27644490
31Serotonergic synapse_Homo sapiens_hsa047261.27053569
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25437123
33Axon guidance_Homo sapiens_hsa043601.24605334
34Renin secretion_Homo sapiens_hsa049241.24018428
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21216958
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.20986100
37Bile secretion_Homo sapiens_hsa049761.18107539
38GnRH signaling pathway_Homo sapiens_hsa049121.15535931
39Oxytocin signaling pathway_Homo sapiens_hsa049211.13880418
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11456802
41Long-term depression_Homo sapiens_hsa047301.10070167
42Calcium signaling pathway_Homo sapiens_hsa040201.06775613
43Butanoate metabolism_Homo sapiens_hsa006501.06608361
44Glioma_Homo sapiens_hsa052141.00979425
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00781942
46Gap junction_Homo sapiens_hsa045401.00738953
47cAMP signaling pathway_Homo sapiens_hsa040241.00466318
48Amoebiasis_Homo sapiens_hsa051461.00267179
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99698711
50Protein digestion and absorption_Homo sapiens_hsa049740.98760770
51ErbB signaling pathway_Homo sapiens_hsa040120.98606142
52Vitamin B6 metabolism_Homo sapiens_hsa007500.97640120
53Estrogen signaling pathway_Homo sapiens_hsa049150.94929843
54Dorso-ventral axis formation_Homo sapiens_hsa043200.92908363
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90051486
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.88666704
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88389594
58Melanogenesis_Homo sapiens_hsa049160.87083916
59Proteoglycans in cancer_Homo sapiens_hsa052050.84353794
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83866133
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82330594
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80731058
63Dilated cardiomyopathy_Homo sapiens_hsa054140.76777056
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76177376
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75470640
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73982651
67Hippo signaling pathway_Homo sapiens_hsa043900.71420331
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71219975
69Fatty acid biosynthesis_Homo sapiens_hsa000610.70172707
70Prion diseases_Homo sapiens_hsa050200.66801917
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.66012619
72Fatty acid metabolism_Homo sapiens_hsa012120.65674309
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.64933604
74Adherens junction_Homo sapiens_hsa045200.64907562
75PPAR signaling pathway_Homo sapiens_hsa033200.64305406
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63433341
77Glucagon signaling pathway_Homo sapiens_hsa049220.62976184
78Insulin signaling pathway_Homo sapiens_hsa049100.62144168
79Tight junction_Homo sapiens_hsa045300.61896393
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.61362019
81Notch signaling pathway_Homo sapiens_hsa043300.60523161
82Ovarian steroidogenesis_Homo sapiens_hsa049130.60039854
83Thyroid hormone synthesis_Homo sapiens_hsa049180.59689683
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.59242444
85Endometrial cancer_Homo sapiens_hsa052130.58917019
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58541292
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56251582
88Collecting duct acid secretion_Homo sapiens_hsa049660.55989651
89Inositol phosphate metabolism_Homo sapiens_hsa005620.55819650
90MAPK signaling pathway_Homo sapiens_hsa040100.54581153
91mTOR signaling pathway_Homo sapiens_hsa041500.54052364
92Choline metabolism in cancer_Homo sapiens_hsa052310.53728733
93Complement and coagulation cascades_Homo sapiens_hsa046100.53366333
94Tryptophan metabolism_Homo sapiens_hsa003800.53087209
95Phenylalanine metabolism_Homo sapiens_hsa003600.52856747
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.52303126
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51988385
98Chronic myeloid leukemia_Homo sapiens_hsa052200.51851099
99Ras signaling pathway_Homo sapiens_hsa040140.50474713
100Pancreatic secretion_Homo sapiens_hsa049720.48027994
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46805286
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45932323
103Fatty acid degradation_Homo sapiens_hsa000710.45646748
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45492271
105Rap1 signaling pathway_Homo sapiens_hsa040150.45236874
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43025583
107Cardiac muscle contraction_Homo sapiens_hsa042600.41050714
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40426748
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40394459
110Insulin resistance_Homo sapiens_hsa049310.40377608
111Renal cell carcinoma_Homo sapiens_hsa052110.40364182
112Wnt signaling pathway_Homo sapiens_hsa043100.39145300
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38872626
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35167551
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.34851074
116AMPK signaling pathway_Homo sapiens_hsa041520.34679493
117Vibrio cholerae infection_Homo sapiens_hsa051100.33004784
118VEGF signaling pathway_Homo sapiens_hsa043700.32883033
119Endocytosis_Homo sapiens_hsa041440.32772552
120Prolactin signaling pathway_Homo sapiens_hsa049170.32042173
121Circadian rhythm_Homo sapiens_hsa047100.31658483

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »