CTLA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of MHC class II biosynthetic process (GO:0045346)9.36641951
2regulation of cytokine secretion involved in immune response (GO:0002739)8.65282085
3negative regulation of nitric oxide biosynthetic process (GO:0045019)8.45769840
4response to inactivity (GO:0014854)8.10366658
5negative regulation of interleukin-12 production (GO:0032695)8.02746158
6cytidine deamination (GO:0009972)7.67672687
7cytidine metabolic process (GO:0046087)7.67672687
8cytidine catabolic process (GO:0006216)7.67672687
9branching involved in labyrinthine layer morphogenesis (GO:0060670)7.47761498
10tolerance induction (GO:0002507)7.32733444
11regulation of isotype switching to IgG isotypes (GO:0048302)7.28428480
12pyrimidine ribonucleoside catabolic process (GO:0046133)7.16655981
13negative regulation of cell killing (GO:0031342)7.13516397
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.13516397
15negative regulation of inflammatory response to antigenic stimulus (GO:0002862)7.08936172
16* negative regulation of B cell proliferation (GO:0030889)7.03367236
17regulation of isotype switching (GO:0045191)6.88623459
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.48300381
19DNA deamination (GO:0045006)6.11662908
20response to interleukin-15 (GO:0070672)6.09468502
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.04746961
22cellular response to interleukin-15 (GO:0071350)5.98137131
23regulation of tumor necrosis factor biosynthetic process (GO:0042534)5.87802779
24negative T cell selection (GO:0043383)5.85987777
25negative thymic T cell selection (GO:0045060)5.72708579
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.48611708
27negative regulation of T-helper cell differentiation (GO:0045623)5.35111701
28negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.35111701
29glial cell proliferation (GO:0014009)5.34123300
30negative regulation of NF-kappaB import into nucleus (GO:0042347)5.25748102
31negative regulation of cytokine production involved in immune response (GO:0002719)5.22128832
32positive regulation of lymphocyte apoptotic process (GO:0070230)5.18371557
33regulation of tolerance induction (GO:0002643)4.97695094
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90345504
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.82330394
36positive thymic T cell selection (GO:0045059)4.80503979
37thymic T cell selection (GO:0045061)4.80266779
38regulation of immunoglobulin mediated immune response (GO:0002889)4.78575005
39regulation of immunoglobulin production (GO:0002637)4.74588957
40T cell selection (GO:0045058)4.68752748
41T-helper cell differentiation (GO:0042093)4.63634002
42CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.63634002
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.63454909
44regulation of B cell mediated immunity (GO:0002712)4.62775781
45regulation of inflammatory response to antigenic stimulus (GO:0002861)4.60413215
46positive T cell selection (GO:0043368)4.57448974
47tyrosine phosphorylation of STAT protein (GO:0007260)4.54663774
48regulation of interferon-alpha production (GO:0032647)4.54346338
49negative regulation of production of molecular mediator of immune response (GO:0002701)4.51383093
50positive regulation of gamma-delta T cell activation (GO:0046645)4.45467369
51regulation of B cell apoptotic process (GO:0002902)4.43420178
52T cell lineage commitment (GO:0002360)4.37255594
53* negative regulation of B cell activation (GO:0050869)4.36527011
54regulation of interleukin-2 biosynthetic process (GO:0045076)4.36494749
55positive regulation of natural killer cell mediated immunity (GO:0002717)4.34493922
56cytoplasmic sequestering of transcription factor (GO:0042994)4.29185461
57B cell proliferation (GO:0042100)4.28375235
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.27472360
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.20711000
60regulation of T cell tolerance induction (GO:0002664)4.19192895
61leukocyte aggregation (GO:0070486)4.18463372
62* regulation of regulatory T cell differentiation (GO:0045589)4.18127172
63activated T cell proliferation (GO:0050798)4.17923710
64* regulation of B cell proliferation (GO:0030888)4.16689146
65regulation of natural killer cell mediated immunity (GO:0002715)4.14431105
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.14431105
67negative regulation of adaptive immune response (GO:0002820)4.14298635
68positive regulation of isotype switching (GO:0045830)4.13954075
69regulation of interleukin-13 production (GO:0032656)4.07975919
70regulation of membrane protein ectodomain proteolysis (GO:0051043)4.05201022
71alpha-beta T cell differentiation involved in immune response (GO:0002293)4.03117738
72alpha-beta T cell activation involved in immune response (GO:0002287)4.03117738
73T cell differentiation involved in immune response (GO:0002292)4.03117738
74modulation of growth of symbiont involved in interaction with host (GO:0044144)3.98031481
75regulation of growth of symbiont in host (GO:0044126)3.98031481
76negative regulation of growth of symbiont in host (GO:0044130)3.98031481
77negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.98031481
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.95919455
79negative regulation of interferon-gamma production (GO:0032689)3.91928423
80positive regulation of cell killing (GO:0031343)3.90752167
81regulation of alpha-beta T cell proliferation (GO:0046640)3.87184859
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.86136868
83regulation of gamma-delta T cell differentiation (GO:0045586)3.82163606
84negative regulation of T cell apoptotic process (GO:0070233)3.81744617
85antigen processing and presentation of endogenous antigen (GO:0019883)3.78191951
86regulation of T cell receptor signaling pathway (GO:0050856)3.76352040
87* lymphocyte costimulation (GO:0031294)3.75753451
88T cell receptor signaling pathway (GO:0050852)3.72087763
89positive regulation of alpha-beta T cell proliferation (GO:0046641)3.71134596
90* antigen receptor-mediated signaling pathway (GO:0050851)3.70582366
91myeloid dendritic cell differentiation (GO:0043011)3.66957847
92regulation of B cell receptor signaling pathway (GO:0050855)3.65924253
93myeloid dendritic cell activation (GO:0001773)3.65617086
94cytoplasmic sequestering of protein (GO:0051220)3.65425777
95regulation of cell killing (GO:0031341)3.62768988
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.62675780
97negative regulation of T cell mediated immunity (GO:0002710)3.59572236
98positive regulation of defense response to virus by host (GO:0002230)3.59519870
99regulation of lymphocyte chemotaxis (GO:1901623)3.56938001
100interferon-gamma production (GO:0032609)3.52597466
101positive regulation of interleukin-4 production (GO:0032753)3.52398248
102regulation of leukocyte mediated cytotoxicity (GO:0001910)3.52282947
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51948076
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51948076
105Arp2/3 complex-mediated actin nucleation (GO:0034314)3.51933531
106positive regulation of DNA recombination (GO:0045911)3.51809123
107negative regulation by host of viral transcription (GO:0043922)3.51363849
108CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.50841410
109negative regulation of cytokine biosynthetic process (GO:0042036)3.49447817
110negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.49167509
111negative regulation of viral genome replication (GO:0045071)3.49075941
112positive regulation of calcium-mediated signaling (GO:0050850)3.46787110
113T cell migration (GO:0072678)3.45459096
114negative regulation of alpha-beta T cell differentiation (GO:0046639)3.43590851
115positive regulation of tolerance induction (GO:0002645)3.40208642
116regulation of T cell chemotaxis (GO:0010819)3.40048377
117positive regulation of T cell chemotaxis (GO:0010820)3.40048377
118positive regulation of leukocyte apoptotic process (GO:2000108)3.39086771
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.38982817
120regulation of gamma-delta T cell activation (GO:0046643)3.38957723
121positive regulation of interleukin-8 secretion (GO:2000484)3.37325228
122alpha-beta T cell differentiation (GO:0046632)3.36966506
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.36675379
124corticosteroid receptor signaling pathway (GO:0031958)3.34659616
125regulation of interleukin-12 biosynthetic process (GO:0045075)3.34604560
126positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34567478
127growth hormone receptor signaling pathway (GO:0060396)3.33745834
128positive regulation of lymphocyte migration (GO:2000403)3.32799832
129pyrimidine nucleoside catabolic process (GO:0046135)3.31514650
130regulation of lymphocyte mediated immunity (GO:0002706)3.30385144
131* T cell costimulation (GO:0031295)3.29294023
132eosinophil chemotaxis (GO:0048245)3.26731932
133positive regulation of interleukin-1 beta secretion (GO:0050718)3.24195480
134* negative regulation of T cell proliferation (GO:0042130)3.24146009
135positive regulation of activated T cell proliferation (GO:0042104)3.23157598
136alpha-beta T cell activation (GO:0046631)3.22970709
137negative regulation of osteoclast differentiation (GO:0045671)3.22281033
138regulation of interleukin-2 production (GO:0032663)3.21141402
139regulation of T cell mediated cytotoxicity (GO:0001914)3.19660486
140regulation of B cell differentiation (GO:0045577)3.19490167
141positive regulation of interleukin-2 production (GO:0032743)3.19181592
142positive regulation of B cell differentiation (GO:0045579)3.17511020
143regulation of interleukin-4 production (GO:0032673)3.17226733
144antigen processing and presentation via MHC class Ib (GO:0002475)3.17211884
145CD4-positive, alpha-beta T cell activation (GO:0035710)3.15974090
146positive regulation of lymphocyte mediated immunity (GO:0002708)3.15662430
147T cell homeostasis (GO:0043029)3.15175725
148chemokine-mediated signaling pathway (GO:0070098)3.14071493
149regulation of interleukin-1 beta secretion (GO:0050706)3.13442009
150* negative regulation of T cell activation (GO:0050868)3.12944383
151regulation of activation of Janus kinase activity (GO:0010533)3.12299932
152defense response to protozoan (GO:0042832)3.11697439
153lymphocyte chemotaxis (GO:0048247)3.09688392
154T cell differentiation (GO:0030217)3.09063750
155negative regulation of T cell receptor signaling pathway (GO:0050860)3.04349298
156regulation of chronic inflammatory response (GO:0002676)12.8907083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.54765480
2* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.73437117
3RUNX_20019798_ChIP-Seq_JUKART_Human4.59965601
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.21018399
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.81104647
6* MYB_26560356_Chip-Seq_TH2_Human3.46084298
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.35159329
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.28492324
9E2F7_22180533_ChIP-Seq_HELA_Human2.97217123
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.94105209
11* MAF_26560356_Chip-Seq_TH1_Human2.85619858
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.75719339
13MYC_22102868_ChIP-Seq_BL_Human2.73770268
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67291290
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64889324
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49615987
17* MYB_26560356_Chip-Seq_TH1_Human2.47322846
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45792511
19UTX_26944678_Chip-Seq_JUKART_Human2.35514779
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.30080578
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22786589
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.15838869
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08406782
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04600176
25GATA3_27048872_Chip-Seq_THYMUS_Human2.04564771
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02722817
27VDR_21846776_ChIP-Seq_THP-1_Human2.02048308
28* FOXP3_17237761_ChIP-ChIP_TREG_Mouse10.3636011
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99467057
30TCF7_22412390_ChIP-Seq_EML_Mouse1.99418590
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97990508
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75837712
33SCL_19346495_ChIP-Seq_HPC-7_Human1.73890783
34* IRF8_27001747_Chip-Seq_BMDM_Mouse1.68254172
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66951524
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65479132
37* MAF_26560356_Chip-Seq_TH2_Human1.59594232
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59174321
39CIITA_25753668_ChIP-Seq_RAJI_Human1.57381791
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55539088
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55000041
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53961950
43* PU_27001747_Chip-Seq_BMDM_Mouse1.53848787
44GATA3_26560356_Chip-Seq_TH2_Human1.53331529
45KDM2B_26808549_Chip-Seq_DND41_Human1.51153461
46VDR_23849224_ChIP-Seq_CD4+_Human1.50289370
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46274670
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45674421
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43366017
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.42841346
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.42819314
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.41510711
53VDR_24763502_ChIP-Seq_THP-1_Human1.39579928
54GATA1_19941826_ChIP-Seq_K562_Human1.38294015
55GATA1_22025678_ChIP-Seq_K562_Human1.32155853
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26689168
57FOXP3_21729870_ChIP-Seq_TREG_Human1.25730691
58SPI1_23127762_ChIP-Seq_K562_Human1.24872638
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24512864
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.21654038
61SPI1_23547873_ChIP-Seq_NB4_Human1.17896999
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17867209
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15437673
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11868053
65VDR_24787735_ChIP-Seq_THP-1_Human1.11677305
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11117720
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10025035
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09041368
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08798046
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08793475
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.07894991
72GATA2_19941826_ChIP-Seq_K562_Human1.07863964
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.07593845
74AR_21572438_ChIP-Seq_LNCaP_Human1.04170733
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.02674489
76GATA3_26560356_Chip-Seq_TH1_Human1.02554203
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02414272
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99415459
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96109075
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92747257
81* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90633548
82* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87161394
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85443551
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84530875
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84020775
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82775226
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82361519
88GABP_17652178_ChIP-ChIP_JURKAT_Human0.81317996
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80295970
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77873875
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.77714945
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77375142
93* FLI1_27457419_Chip-Seq_LIVER_Mouse0.76593816
94CLOCK_20551151_ChIP-Seq_293T_Human0.75597440
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74755697
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73652565
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73034542
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73014546
99SMRT_27268052_Chip-Seq_Bcells_Human0.72418493
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72270624
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71482348
102EST1_17652178_ChIP-ChIP_JURKAT_Human0.71450977
103* NFE2_27457419_Chip-Seq_LIVER_Mouse0.71205230
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69366082
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.66542705
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66527437
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.66214209
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66113243
109BCL6_27268052_Chip-Seq_Bcells_Human0.66040960
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65678659
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64963945
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.64772027
113TAF15_26573619_Chip-Seq_HEK293_Human0.64620642
114* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63713001
115GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.63157729
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62256731
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62194315
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.61864036
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61713177
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61535420
121NCOR1_26117541_ChIP-Seq_K562_Human0.61053939
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.60855612
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60384601
124P300_27268052_Chip-Seq_Bcells_Human0.58680694
125RXR_22108803_ChIP-Seq_LS180_Human0.58528520
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.58299929
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57474162
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.55575845
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.55141632
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.55103691
131TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.55026551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation7.84024487
2MP0003300_gastrointestinal_ulcer7.00467888
3MP0005671_abnormal_response_to5.09632335
4MP0003763_abnormal_thymus_physiology4.51264228
5MP0005387_immune_system_phenotype2.97537256
6MP0001790_abnormal_immune_system2.97537256
7MP0001835_abnormal_antigen_presentation2.92660371
8* MP0001873_stomach_inflammation2.78187361
9MP0006082_CNS_inflammation2.72097454
10MP0001348_abnormal_lacrimal_gland2.55948386
11* MP0001800_abnormal_humoral_immune2.52284982
12MP0002332_abnormal_exercise_endurance2.34601329
13MP0003724_increased_susceptibility_to2.29257094
14MP0010155_abnormal_intestine_physiology2.22059226
15* MP0005000_abnormal_immune_tolerance2.20706643
16MP0001542_abnormal_bone_strength2.13403545
17MP0000490_abnormal_crypts_of2.08140655
18MP0003436_decreased_susceptibility_to2.04320450
19MP0002277_abnormal_respiratory_mucosa2.00996295
20MP0001501_abnormal_sleep_pattern1.99232413
21MP0004947_skin_inflammation1.98785782
22* MP0002723_abnormal_immune_serum1.98348182
23MP0009785_altered_susceptibility_to1.95883416
24MP0003866_abnormal_defecation1.93435382
25MP0005025_abnormal_response_to1.90056012
26MP0009333_abnormal_splenocyte_physiolog1.86977083
27* MP0002452_abnormal_antigen_presenting1.83291112
28MP0001919_abnormal_reproductive_system1.81395696
29MP0004510_myositis1.80722875
30MP0000465_gastrointestinal_hemorrhage1.80683241
31* MP0002420_abnormal_adaptive_immunity1.77829628
32* MP0002398_abnormal_bone_marrow1.76863177
33* MP0001819_abnormal_immune_cell1.75969795
34MP0002138_abnormal_hepatobiliary_system1.75046393
35* MP0000703_abnormal_thymus_morphology1.66734629
36MP0002148_abnormal_hypersensitivity_rea1.62915731
37MP0002166_altered_tumor_susceptibility1.59585817
38* MP0000716_abnormal_immune_system1.57922881
39MP0000685_abnormal_immune_system1.57755979
40MP0003075_altered_response_to1.56785919
41MP0001533_abnormal_skeleton_physiology1.53032497
42MP0005023_abnormal_wound_healing1.49776560
43* MP0002405_respiratory_system_inflammati1.48116526
44MP0002163_abnormal_gland_morphology1.45646286
45* MP0001663_abnormal_digestive_system1.43980141
46* MP0002722_abnormal_immune_system1.40277534
47* MP0001845_abnormal_inflammatory_respons1.37661990
48* MP0002933_joint_inflammation1.31778232
49MP0000343_altered_response_to1.31501690
50MP0005165_increased_susceptibility_to1.31209239
51MP0005075_abnormal_melanosome_morpholog1.29568438
52MP0005167_abnormal_blood-brain_barrier1.24796178
53* MP0000689_abnormal_spleen_morphology1.18017876
54MP0001881_abnormal_mammary_gland1.16842686
55* MP0002429_abnormal_blood_cell1.16732156
56MP0002006_tumorigenesis1.16559105
57MP0002419_abnormal_innate_immunity1.15295615
58* MP0005310_abnormal_salivary_gland1.10316638
59MP0002009_preneoplasia1.06116488
60MP0010352_gastrointestinal_tract_polyps1.06004881
61MP0001764_abnormal_homeostasis1.02026505
62MP0010307_abnormal_tumor_latency0.99158436
63MP0002396_abnormal_hematopoietic_system0.98803055
64MP0005076_abnormal_cell_differentiation0.96190129
65MP0003448_altered_tumor_morphology0.95604799
66MP0000569_abnormal_digit_pigmentation0.95551358
67MP0005464_abnormal_platelet_physiology0.95504472
68MP0003786_premature_aging0.94979904
69MP0008469_abnormal_protein_level0.94519373
70MP0008872_abnormal_physiological_respon0.93373136
71MP0000477_abnormal_intestine_morphology0.91933396
72* MP0005381_digestive/alimentary_phenotyp0.91887446
73MP0005397_hematopoietic_system_phenotyp0.87626073
74MP0001545_abnormal_hematopoietic_system0.87626073
75MP0000013_abnormal_adipose_tissue0.87607953
76MP0004808_abnormal_hematopoietic_stem0.86518705
77MP0009765_abnormal_xenobiotic_induced0.86018088
78MP0000627_abnormal_mammary_gland0.85130476
79MP0005379_endocrine/exocrine_gland_phen0.83493449
80MP0009764_decreased_sensitivity_to0.79465218
81MP0003795_abnormal_bone_structure0.79213033
82MP0005389_reproductive_system_phenotype0.76453049
83* MP0001853_heart_inflammation0.71937071
84MP0002998_abnormal_bone_remodeling0.71451285
85MP0008569_lethality_at_weaning0.70743394
86MP0004084_abnormal_cardiac_muscle0.70225947
87MP0000372_irregular_coat_pigmentation0.69948453
88MP0009763_increased_sensitivity_to0.68940904
89MP0001851_eye_inflammation0.66715912
90* MP0002693_abnormal_pancreas_physiology0.65985704
91MP0003172_abnormal_lysosome_physiology0.65594389
92MP0008874_decreased_physiological_sensi0.62625707
93MP0000371_diluted_coat_color0.62308333
94MP0005266_abnormal_metabolism0.61515777
95MP0008873_increased_physiological_sensi0.61285211
96MP0000015_abnormal_ear_pigmentation0.60870968
97MP0002136_abnormal_kidney_physiology0.58605139
98MP0005166_decreased_susceptibility_to0.58213442
99MP0005390_skeleton_phenotype0.58135635
100MP0005645_abnormal_hypothalamus_physiol0.58036380
101MP0002876_abnormal_thyroid_physiology0.55117046
102MP0000858_altered_metastatic_potential0.53853767
103MP0001958_emphysema0.52024487
104MP0000604_amyloidosis0.50896937
105MP0004381_abnormal_hair_follicle0.49258416
106MP0008057_abnormal_DNA_replication0.48994790
107MP0005197_abnormal_uvea_morphology0.48395571
108MP0008961_abnormal_basal_metabolism0.47784889
109MP0003045_fibrosis0.47734431
110MP0000609_abnormal_liver_physiology0.47308364
111MP0002877_abnormal_melanocyte_morpholog0.47150642
112MP0003566_abnormal_cell_adhesion0.46591477
113MP0002733_abnormal_thermal_nociception0.46582321
114MP0003453_abnormal_keratinocyte_physiol0.46569211
115MP0002254_reproductive_system_inflammat0.46148785
116MP0002019_abnormal_tumor_incidence0.44525240
117MP0003183_abnormal_peptide_metabolism0.44361255
118MP0005584_abnormal_enzyme/coenzyme_acti0.43799767
119* MP0000249_abnormal_blood_vessel0.43512276
120MP0005595_abnormal_vascular_smooth0.43217311
121MP0005535_abnormal_body_temperature0.43146496
122MP0005636_abnormal_mineral_homeostasis0.41279976
123MP0002098_abnormal_vibrissa_morphology0.41174633
124MP0008995_early_reproductive_senescence0.40642893
125MP0004145_abnormal_muscle_electrophysio0.40040761
126MP0005174_abnormal_tail_pigmentation0.39065997
127MP0001191_abnormal_skin_condition0.38881946
128MP0000367_abnormal_coat/_hair0.37563299
129MP0005451_abnormal_body_composition0.37213394
130MP0002168_other_aberrant_phenotype0.37124597
131MP0009643_abnormal_urine_homeostasis0.35693631
132MP0003806_abnormal_nucleotide_metabolis0.35570617
133* MP0002083_premature_death0.35468810
134MP0002095_abnormal_skin_pigmentation0.33099843
135MP0003868_abnormal_feces_composition0.33095114

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)9.44363096
2Keratoconjunctivitis sicca (HP:0001097)8.11393326
3Keratoconjunctivitis (HP:0001096)7.45094468
4Arterial thrombosis (HP:0004420)6.75540013
5* Pulmonary infiltrates (HP:0002113)5.44360424
6* Gangrene (HP:0100758)5.02569103
7* Pulmonary embolism (HP:0002204)4.94262625
8* Hemoptysis (HP:0002105)4.89368016
9Increased IgM level (HP:0003496)4.89337084
10T lymphocytopenia (HP:0005403)4.79953371
11Abnormality of T cell number (HP:0011839)4.53457730
12Gastrointestinal infarctions (HP:0005244)4.46513828
13Encephalitis (HP:0002383)4.43846204
14Anorexia (HP:0002039)4.27547377
15Severe combined immunodeficiency (HP:0004430)4.23158400
16* Vasculitis (HP:0002633)4.10839904
17Aplastic anemia (HP:0001915)3.90566439
18Agammaglobulinemia (HP:0004432)3.83664652
19Hypoproteinemia (HP:0003075)3.82763635
20* Thrombophlebitis (HP:0004418)3.82675778
21Combined immunodeficiency (HP:0005387)3.71329956
22IgM deficiency (HP:0002850)3.61300305
23Fatigue (HP:0012378)3.61031726
24Hypoplasia of the thymus (HP:0000778)3.60931341
25* Glomerulopathy (HP:0100820)3.59984648
26Abnormality of T cells (HP:0002843)3.47775807
27Keratitis (HP:0000491)3.47458676
28Recurrent skin infections (HP:0001581)3.36805051
29* Abnormality of the pericardium (HP:0001697)3.34849511
30Eosinophilia (HP:0001880)3.30268732
31* Meningitis (HP:0001287)3.23392271
32Stomatitis (HP:0010280)3.22039499
33B lymphocytopenia (HP:0010976)3.21126376
34Abnormality of B cell number (HP:0010975)3.21126376
35Eczematoid dermatitis (HP:0000976)3.16702352
36Granulocytopenia (HP:0001913)3.15503889
37Pustule (HP:0200039)3.13794602
38* Abnormality of the pleura (HP:0002103)3.10591271
39IgA deficiency (HP:0002720)3.09080485
40Recurrent bronchitis (HP:0002837)3.01403629
41* Polyneuropathy (HP:0001271)2.97310312
42Elevated erythrocyte sedimentation rate (HP:0003565)2.93696252
43Abnormality of macrophages (HP:0004311)2.90739879
44Vertigo (HP:0002321)2.89812125
45Recurrent fungal infections (HP:0002841)2.85809537
46Panhypogammaglobulinemia (HP:0003139)2.85006871
47Joint swelling (HP:0001386)2.69045176
48Abnormality of the endocardium (HP:0004306)2.65022873
49Recurrent bacterial skin infections (HP:0005406)2.62121629
50Chronic diarrhea (HP:0002028)2.61277103
51Aseptic necrosis (HP:0010885)2.60576369
52Recurrent abscess formation (HP:0002722)2.59582169
53Gingival bleeding (HP:0000225)2.56556826
54Acne (HP:0001061)2.56080995
55* Chest pain (HP:0100749)2.53699090
56* Pancreatitis (HP:0001733)2.53280960
57Amaurosis fugax (HP:0100576)2.48923289
58Recurrent otitis media (HP:0000403)2.44468991
59Hypergammaglobulinemia (HP:0010702)2.42154864
60IgG deficiency (HP:0004315)2.39575189
61Recurrent viral infections (HP:0004429)2.37766607
62Abnormality of T cell physiology (HP:0011840)2.34970750
63* Paresthesia (HP:0003401)2.32949515
64Autoimmune thrombocytopenia (HP:0001973)2.30253538
65Increased intracranial pressure (HP:0002516)2.27386334
66Abnormality of intracranial pressure (HP:0012640)2.27386334
67Diplopia (HP:0000651)2.26622420
68Abnormality of binocular vision (HP:0011514)2.26622420
69* Cerebral ischemia (HP:0002637)2.23636190
70Mediastinal lymphadenopathy (HP:0100721)2.17252011
71Thyroiditis (HP:0100646)2.14847075
72Hypochromic anemia (HP:0001931)2.11575636
73Hypoalbuminemia (HP:0003073)2.10097808
74Abnormal albumin level (HP:0012116)2.10097808
75Abnormality of eosinophils (HP:0001879)2.06989769
76Autoimmune hemolytic anemia (HP:0001890)2.06744027
77Polycythemia (HP:0001901)2.05453225
78Leukocytosis (HP:0001974)2.05260177
79Spontaneous hematomas (HP:0007420)2.03727957
80Inflammation of the large intestine (HP:0002037)2.02727852
81* Abnormality of the prostate (HP:0008775)2.02526856
82Thrombocytosis (HP:0001894)2.01850656
83* Skin rash (HP:0000988)2.00698443
84Retrobulbar optic neuritis (HP:0100654)12.5506948
85Optic neuritis (HP:0100653)12.5506948
86Orchitis (HP:0100796)10.9008015
87* Arthralgia (HP:0002829)1.97990554
88Menstrual irregularities (HP:0000858)1.96513017
89Gastrointestinal inflammation (HP:0004386)1.95690014
90Verrucae (HP:0200043)1.95035847
91Papilloma (HP:0012740)1.95035847
92Gastrointestinal stroma tumor (HP:0100723)1.93436440
93Abnormality of the fingertips (HP:0001211)1.92591263
94Seborrheic dermatitis (HP:0001051)1.92331619
95Abnormal platelet volume (HP:0011876)1.91311296
96Hemiplegia (HP:0002301)1.89995388
97Alveolar cell carcinoma (HP:0006519)1.86418702
98Chronic mucocutaneous candidiasis (HP:0002728)1.82029651
99Recurrent cutaneous fungal infections (HP:0011370)1.82029651
100Lymphopenia (HP:0001888)1.81558963
101* Obstructive lung disease (HP:0006536)1.80803100
102* Chronic obstructive pulmonary disease (HP:0006510)1.80803100
103Hepatosplenomegaly (HP:0001433)1.78672216
104Ileus (HP:0002595)1.78476153
105Recurrent sinusitis (HP:0011108)1.78149451
106Oral leukoplakia (HP:0002745)1.77886327
107Increased mean platelet volume (HP:0011877)1.77600082
108Memory impairment (HP:0002354)1.77503067
109Neoplasm of the tracheobronchial system (HP:0100552)1.75151095
110Colitis (HP:0002583)1.74585082
111Papilledema (HP:0001085)1.73388266
112Hematochezia (HP:0002573)1.73378319
113Peritonitis (HP:0002586)1.73091105
114* Epistaxis (HP:0000421)1.72630427
115Esophageal varix (HP:0002040)1.72320100
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.71333216
117Abnormal delayed hypersensitivity skin test (HP:0002963)1.71227542
118Urticaria (HP:0001025)1.70963663
119Gingivitis (HP:0000230)1.70664081
120Acute hepatic failure (HP:0006554)1.70564887
121Chronic otitis media (HP:0000389)1.69156926
122Premature loss of primary teeth (HP:0006323)1.69097644
123* Ureteral stenosis (HP:0000071)1.68146730
124Septate vagina (HP:0001153)1.67309992
125Myocardial infarction (HP:0001658)1.67017119
126Type I diabetes mellitus (HP:0100651)1.66810158
127Neutropenia (HP:0001875)1.65100438
128Basal cell carcinoma (HP:0002671)1.64764607
129Lymphoma (HP:0002665)1.64637860
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.63856503
131Acute myeloid leukemia (HP:0004808)1.60661470
132Bronchitis (HP:0012387)1.57939988
133Petechiae (HP:0000967)1.57328922
134Nasal polyposis (HP:0100582)1.54687895
135* Retinopathy (HP:0000488)1.51972386
136* Ureteral obstruction (HP:0006000)1.50825421
137Increased IgE level (HP:0003212)1.50438483
138Metabolic alkalosis (HP:0200114)1.49547538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* TXK6.81027659
2MAP4K15.15717277
3JAK34.18164395
4ITK3.80099603
5JAK13.24484320
6ZAP703.19533801
7FGFR42.84693561
8KDR2.61984860
9MAP3K142.57812646
10TEC2.36473340
11STK102.34018608
12RIPK42.21769300
13FGFR32.20107129
14TYK22.02816370
15EPHA31.94613234
16IKBKE1.85457699
17* LCK1.78211763
18SYK1.74677514
19HCK1.73746225
20EPHB11.66965935
21PRKCQ1.50833095
22TRIB31.49802385
23BTK1.47252139
24CAMKK21.39358690
25TBK11.35008450
26ALK1.33994866
27GRK71.29658094
28CDK61.29641127
29PASK1.29410871
30NLK1.21641629
31IKBKB1.21555153
32STK241.20391268
33PRKCH1.16925263
34CSK1.14899402
35* JAK21.12912017
36FES1.12849744
37GRK61.09755611
38CHUK1.09630479
39MAP3K71.08751831
40EEF2K1.05870912
41TYRO31.04576459
42ADRBK21.01910150
43PRPF4B1.01150979
44PDK11.00082240
45MST40.96334183
46MAPK110.93457424
47LRRK20.90804007
48IRAK10.88086806
49CAMKK10.82377169
50CDK120.79148755
51BMPR20.77869888
52HIPK20.77551213
53SIK20.77365633
54CDK40.75955245
55IRAK40.75316752
56MAP3K130.75001793
57MARK30.74805977
58TAOK30.74348932
59PDPK10.68694348
60TNK20.67332204
61PDGFRB0.66228406
62PIM10.65167515
63MAPK150.65141378
64BCR0.62044013
65NME20.61363681
66MAPK40.61116208
67PKN20.60887029
68MAPK120.59680813
69LYN0.59567495
70MAP2K60.59338302
71BUB10.58544543
72RET0.58017097
73PTK60.57050841
74KIT0.55134597
75DMPK0.54976131
76FGFR10.53955361
77CDK90.53670469
78MAPKAPK30.53040033
79MELK0.50458964
80IGF1R0.48657124
81TLK10.48528858
82VRK10.47326571
83CLK10.46723004
84TAOK10.44347401
85IRAK20.43632179
86PIK3CA0.41647772
87INSR0.39803976
88MAP3K100.39719441
89CSNK1D0.39292978
90ABL10.38264348
91RPS6KA40.38255205
92WNK10.38052420
93NUAK10.36903455
94NEK90.36703150
95MAP3K10.35535097
96* FYN0.32546014
97EIF2AK30.31308397
98SIK30.30337701
99PIK3CG0.29898547
100TGFBR20.29817212
101WNK40.27987587
102CSF1R0.27722503
103TTN0.27362692
104MAPK30.27177662
105ROCK20.25714400
106EGFR0.25281674
107MAPK70.24875082
108RPS6KB10.24802339
109MAPKAPK20.22809365
110CSNK1A1L0.22617044
111BLK0.21653985
112MAP3K80.21195590
113MAPK90.20877265
114SIK10.20456294
115MAPK100.19530220
116RPS6KA50.19180516
117NME10.19149630
118SRC0.18988400
119SGK30.18675499
120PRKCB0.17606711
121DYRK1B0.17482404
122TESK20.17449515
123SMG10.16682258
124RAF10.16477417
125MAPK10.16402408
126MAP3K50.15689251
127BMX0.15017733
128MAP3K120.14914649
129GRK10.14720127

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.94441051
2Allograft rejection_Homo sapiens_hsa053306.62398713
3* Autoimmune thyroid disease_Homo sapiens_hsa053205.38328973
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.93498975
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.50896583
6* T cell receptor signaling pathway_Homo sapiens_hsa046603.24512733
7Primary immunodeficiency_Homo sapiens_hsa053403.20517993
8Leishmaniasis_Homo sapiens_hsa051402.80401557
9Staphylococcus aureus infection_Homo sapiens_hsa051502.24098998
10Proteasome_Homo sapiens_hsa030502.09492094
11* Rheumatoid arthritis_Homo sapiens_hsa053232.02744526
12African trypanosomiasis_Homo sapiens_hsa051431.96535128
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.89258700
14Hematopoietic cell lineage_Homo sapiens_hsa046401.85787867
15Measles_Homo sapiens_hsa051621.75201970
16Malaria_Homo sapiens_hsa051441.47221603
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41345321
18Toxoplasmosis_Homo sapiens_hsa051451.38170722
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.26092028
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19377503
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18261788
22Osteoclast differentiation_Homo sapiens_hsa043801.08876143
23Pertussis_Homo sapiens_hsa051331.07653891
24B cell receptor signaling pathway_Homo sapiens_hsa046621.03171280
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98760668
26Chemokine signaling pathway_Homo sapiens_hsa040620.94324882
27Viral myocarditis_Homo sapiens_hsa054160.76706337
28Tuberculosis_Homo sapiens_hsa051520.71972523
29Antigen processing and presentation_Homo sapiens_hsa046120.71427995
30Hepatitis B_Homo sapiens_hsa051610.68400344
31NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68085078
32* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67202785
33Renal cell carcinoma_Homo sapiens_hsa052110.67061930
34Chronic myeloid leukemia_Homo sapiens_hsa052200.66090097
35FoxO signaling pathway_Homo sapiens_hsa040680.65582542
36Epstein-Barr virus infection_Homo sapiens_hsa051690.64581758
37Prolactin signaling pathway_Homo sapiens_hsa049170.64568241
38Platelet activation_Homo sapiens_hsa046110.63190153
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59601850
40Amoebiasis_Homo sapiens_hsa051460.58733464
41Acute myeloid leukemia_Homo sapiens_hsa052210.58621285
42Pancreatic cancer_Homo sapiens_hsa052120.57194771
43Graft-versus-host disease_Homo sapiens_hsa053320.56795214
44Shigellosis_Homo sapiens_hsa051310.55671458
45TNF signaling pathway_Homo sapiens_hsa046680.54080540
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52091368
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.51444924
48Type I diabetes mellitus_Homo sapiens_hsa049400.50753531
49HTLV-I infection_Homo sapiens_hsa051660.50095125
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50093400
51Regulation of autophagy_Homo sapiens_hsa041400.48683195
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47804874
53RNA polymerase_Homo sapiens_hsa030200.46146763
54Viral carcinogenesis_Homo sapiens_hsa052030.45146086
55Herpes simplex infection_Homo sapiens_hsa051680.42660519
56ErbB signaling pathway_Homo sapiens_hsa040120.40196508
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.38857805
58Small cell lung cancer_Homo sapiens_hsa052220.38825763
59Prion diseases_Homo sapiens_hsa050200.38707041
60Influenza A_Homo sapiens_hsa051640.37306666
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.36019068
62Apoptosis_Homo sapiens_hsa042100.34932149
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33202478
64Systemic lupus erythematosus_Homo sapiens_hsa053220.32519477
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32306892
66MAPK signaling pathway_Homo sapiens_hsa040100.31448839
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30704450
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30514394
69VEGF signaling pathway_Homo sapiens_hsa043700.29474547
70Dorso-ventral axis formation_Homo sapiens_hsa043200.28906515
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28010999
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27891276
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27081861
74MicroRNAs in cancer_Homo sapiens_hsa052060.26591872
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26291977
76Long-term potentiation_Homo sapiens_hsa047200.26119629
77Linoleic acid metabolism_Homo sapiens_hsa005910.25157878
78Non-small cell lung cancer_Homo sapiens_hsa052230.23791137
79Hepatitis C_Homo sapiens_hsa051600.23670000
80Protein export_Homo sapiens_hsa030600.23025631
81mTOR signaling pathway_Homo sapiens_hsa041500.21454212
82Legionellosis_Homo sapiens_hsa051340.21417884
83RNA degradation_Homo sapiens_hsa030180.21086795
84Circadian rhythm_Homo sapiens_hsa047100.21039208
85Colorectal cancer_Homo sapiens_hsa052100.20528082
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20243485
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19563879
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.19513515
89Insulin resistance_Homo sapiens_hsa049310.19295261
90Spliceosome_Homo sapiens_hsa030400.18735057
91HIF-1 signaling pathway_Homo sapiens_hsa040660.18052106
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17280546
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16955966
94Caffeine metabolism_Homo sapiens_hsa002320.16645843
95Endocytosis_Homo sapiens_hsa041440.16526307
96Rap1 signaling pathway_Homo sapiens_hsa040150.16398556
97Prostate cancer_Homo sapiens_hsa052150.15526411
98Salmonella infection_Homo sapiens_hsa051320.14194055
99Inositol phosphate metabolism_Homo sapiens_hsa005620.14112606
100Proteoglycans in cancer_Homo sapiens_hsa052050.13345546
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12550465
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09774835
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.07973252
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.07655314
105Focal adhesion_Homo sapiens_hsa045100.06828878
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06196694
107Phagosome_Homo sapiens_hsa041450.06108574
108Pathways in cancer_Homo sapiens_hsa052000.05889707
109Notch signaling pathway_Homo sapiens_hsa043300.05481878
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.05280514
111Choline metabolism in cancer_Homo sapiens_hsa052310.04909606
112Type II diabetes mellitus_Homo sapiens_hsa049300.04653262
113p53 signaling pathway_Homo sapiens_hsa041150.03780612
114Glycerolipid metabolism_Homo sapiens_hsa005610.03709532
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.03596578
116Ras signaling pathway_Homo sapiens_hsa040140.03427136
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03154160
118cAMP signaling pathway_Homo sapiens_hsa040240.02648581
119Renin secretion_Homo sapiens_hsa049240.02280578
120Dilated cardiomyopathy_Homo sapiens_hsa054140.02161756
121Cholinergic synapse_Homo sapiens_hsa047250.01902411
122Estrogen signaling pathway_Homo sapiens_hsa049150.01421719
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.01243106
124Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0140392

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