CTNNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.40553279
2Golgi transport vesicle coating (GO:0048200)5.40553279
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.71336764
4hemidesmosome assembly (GO:0031581)4.24240555
5paraxial mesoderm development (GO:0048339)3.98141067
6regulation of hippo signaling (GO:0035330)3.88690286
7regulation of cardioblast differentiation (GO:0051890)3.86891208
8sarcomere organization (GO:0045214)3.82539916
9* epithelial cell-cell adhesion (GO:0090136)3.80358229
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.63273479
11hippo signaling (GO:0035329)3.61432957
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51559243
13regulation of SMAD protein import into nucleus (GO:0060390)3.48733014
14positive regulation of SMAD protein import into nucleus (GO:0060391)3.46681315
15desmosome organization (GO:0002934)3.45117368
16protein retention in ER lumen (GO:0006621)3.44352044
17plasma membrane repair (GO:0001778)3.40723717
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.40334754
19basement membrane organization (GO:0071711)3.38650784
20negative regulation of chondrocyte differentiation (GO:0032331)3.36009130
21protein localization to endosome (GO:0036010)3.33100799
22cell adhesion mediated by integrin (GO:0033627)3.31888255
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.30594473
24endocardial cushion development (GO:0003197)3.30350834
25cardiac myofibril assembly (GO:0055003)3.28558836
26regulation of tight junction assembly (GO:2000810)3.23289777
27barbed-end actin filament capping (GO:0051016)3.22581904
28cell-substrate junction assembly (GO:0007044)3.19703611
29polarized epithelial cell differentiation (GO:0030859)3.17477757
30cell migration involved in sprouting angiogenesis (GO:0002042)3.17456837
31renal filtration (GO:0097205)3.17036518
32vascular endothelial growth factor signaling pathway (GO:0038084)3.16882873
33regulation of gene silencing by RNA (GO:0060966)3.16863710
34regulation of posttranscriptional gene silencing (GO:0060147)3.16863710
35regulation of gene silencing by miRNA (GO:0060964)3.16863710
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00780993
37endothelial cell morphogenesis (GO:0001886)2.98984743
38establishment of apical/basal cell polarity (GO:0035089)2.96017043
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96009071
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95792606
41transcytosis (GO:0045056)2.95615275
42vesicle coating (GO:0006901)2.94336153
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92347872
44wound healing, spreading of epidermal cells (GO:0035313)2.92338725
45semaphorin-plexin signaling pathway (GO:0071526)2.92177209
46atrioventricular valve morphogenesis (GO:0003181)2.90203134
47mesodermal cell differentiation (GO:0048333)2.87080006
48adherens junction assembly (GO:0034333)2.86381689
49branching involved in salivary gland morphogenesis (GO:0060445)2.86004572
50actomyosin structure organization (GO:0031032)2.85849800
51endodermal cell differentiation (GO:0035987)2.84431020
52cardiac muscle cell development (GO:0055013)2.80629258
53glomerular basement membrane development (GO:0032836)2.79104841
54blood vessel endothelial cell migration (GO:0043534)2.79049264
55COPII vesicle coating (GO:0048208)2.77903339
56anterior/posterior axis specification, embryo (GO:0008595)2.76196371
57endothelial tube morphogenesis (GO:0061154)2.76170897
58morphogenesis of an endothelium (GO:0003159)2.76170897
59cardiac cell development (GO:0055006)2.74048628
60notochord development (GO:0030903)2.73490560
61interferon-gamma secretion (GO:0072643)2.72659479
62intestinal epithelial cell development (GO:0060576)2.65535115
63ventricular cardiac muscle cell action potential (GO:0086005)2.64712131
64muscle filament sliding (GO:0030049)2.63636537
65actin-myosin filament sliding (GO:0033275)2.63636537
66Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63043325
67membrane protein ectodomain proteolysis (GO:0006509)2.62156170
68establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61210791
69establishment or maintenance of bipolar cell polarity (GO:0061245)2.61210791
70apoptotic process involved in morphogenesis (GO:0060561)2.60795516
71apoptotic cell clearance (GO:0043277)2.60104599
72heart trabecula formation (GO:0060347)2.58524216
73positive regulation of p38MAPK cascade (GO:1900745)2.57429530
74embryonic foregut morphogenesis (GO:0048617)2.56996510
75myofibril assembly (GO:0030239)2.56278707
76branching involved in mammary gland duct morphogenesis (GO:0060444)2.54727171
77regulation of establishment of planar polarity (GO:0090175)2.54130679
78muscle cell migration (GO:0014812)2.53886911
79negative regulation of keratinocyte proliferation (GO:0010839)2.52241180
80glomerular visceral epithelial cell development (GO:0072015)2.51998853
81regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51342958
82tight junction assembly (GO:0070830)2.51142705
83heterochromatin organization (GO:0070828)2.50590702
84dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.50154798
85substrate adhesion-dependent cell spreading (GO:0034446)2.49966121
86negative regulation of cell fate specification (GO:0009996)2.49607346
87collagen fibril organization (GO:0030199)2.49541707
88peptidyl-proline hydroxylation (GO:0019511)2.48679652
89negative regulation of potassium ion transmembrane transport (GO:1901380)2.48110921
90actin-mediated cell contraction (GO:0070252)2.47698831
91ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.47315625
92glomerular filtration (GO:0003094)2.47214364
93surfactant homeostasis (GO:0043129)2.46466495
94establishment of endothelial barrier (GO:0061028)2.45810801
95regulation of endothelial cell differentiation (GO:0045601)2.45764631
96positive regulation of endothelial cell apoptotic process (GO:2000353)2.45226546
97low-density lipoprotein particle clearance (GO:0034383)2.44336086
98regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.44066630
994-hydroxyproline metabolic process (GO:0019471)2.43465990
100regulation of heart morphogenesis (GO:2000826)2.41319955
101cardiac muscle tissue morphogenesis (GO:0055008)2.40794550
102cell fate commitment involved in formation of primary germ layer (GO:0060795)2.40483006
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.40300823
104regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.40010862
105regulation of transforming growth factor beta2 production (GO:0032909)2.39766938
106striated muscle atrophy (GO:0014891)2.39717283
107lymphangiogenesis (GO:0001946)2.37523535
108cell-substrate adherens junction assembly (GO:0007045)2.37008311
109focal adhesion assembly (GO:0048041)2.37008311
110substrate-dependent cell migration (GO:0006929)2.36736935
111trophectodermal cell differentiation (GO:0001829)2.36483829
112protein hydroxylation (GO:0018126)2.35859825
113cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35704625
114regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34992986
115regulation of early endosome to late endosome transport (GO:2000641)2.34971994
116axon extension involved in axon guidance (GO:0048846)2.34857863
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.34857863
118ventricular cardiac muscle cell development (GO:0055015)2.34057643
119cellular copper ion homeostasis (GO:0006878)2.33675546
120glomerular epithelial cell development (GO:0072310)2.32639571
121skin morphogenesis (GO:0043589)2.32539653
122embryonic camera-type eye development (GO:0031076)2.31851842
123chondrocyte proliferation (GO:0035988)2.31674404
124apical protein localization (GO:0045176)2.31358522
125outflow tract septum morphogenesis (GO:0003148)2.30891685
126regulation of p38MAPK cascade (GO:1900744)2.30865868
127wound healing, spreading of cells (GO:0044319)2.30847825
128stress fiber assembly (GO:0043149)2.30343050
129* cell junction assembly (GO:0034329)2.30278243
130negative regulation of cartilage development (GO:0061037)2.29661120
131G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.29622535
132mesenchyme development (GO:0060485)2.28302503
133nuclear pore complex assembly (GO:0051292)2.28183802
134midgut development (GO:0007494)2.28144904
135nuclear pore organization (GO:0006999)2.28046933
136collagen metabolic process (GO:0032963)2.27672136
137extracellular matrix disassembly (GO:0022617)2.27600434
138growth hormone receptor signaling pathway (GO:0060396)2.27398597
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.25677814
140cellular protein complex localization (GO:0034629)2.24362122
141multicellular organismal macromolecule metabolic process (GO:0044259)2.24256598
142morphogenesis of an epithelial sheet (GO:0002011)2.22935814
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22837713
144protein localization to cell surface (GO:0034394)2.22083577
145* cell-cell junction assembly (GO:0007043)2.21932780
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.21651221
147asymmetric protein localization (GO:0008105)2.21070523
148NADPH regeneration (GO:0006740)2.21026151
149convergent extension (GO:0060026)2.20393688
150negative regulation of anoikis (GO:2000811)2.17736673
151mitotic cytokinesis (GO:0000281)2.17542825
152pentose-phosphate shunt (GO:0006098)2.17438246
153actin filament depolymerization (GO:0030042)2.16785196
154endothelial cell chemotaxis (GO:0035767)2.16570396
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.16462954
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.16402154
157protein complex localization (GO:0031503)2.16309501
158activation of Rac GTPase activity (GO:0032863)2.15911857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.42872619
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.25799603
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17725672
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16929031
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10168639
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07398424
7CLOCK_20551151_ChIP-Seq_293T_Human2.98070604
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65329608
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58823953
10ZNF263_19887448_ChIP-Seq_K562_Human2.56070255
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.45317119
12E2F7_22180533_ChIP-Seq_HELA_Human2.38766032
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.37950373
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24172476
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.22841240
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.07479939
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.07342296
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07255016
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07255016
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07255016
21AR_21909140_ChIP-Seq_LNCAP_Human2.06342264
22* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05549298
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96468560
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92883958
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91902240
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91028949
27TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88849674
28SALL4_18804426_ChIP-ChIP_XEN_Mouse1.85877664
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.84133627
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79710017
31ATF3_27146783_Chip-Seq_COLON_Human1.79365885
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78483287
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78483287
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78212403
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75483140
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75185141
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73864563
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72987706
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.71444934
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.65359683
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64351007
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59471215
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57832070
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53789071
45* EP300_21415370_ChIP-Seq_HL-1_Mouse1.53665184
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52704348
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52515892
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50633986
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50618018
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46949464
51* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46563961
52RACK7_27058665_Chip-Seq_MCF-7_Human1.46170908
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.44185747
54* TBX20_22080862_ChIP-Seq_HEART_Mouse1.44185747
55* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41043886
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40029648
57GATA6_25053715_ChIP-Seq_YYC3_Human1.39661066
58* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37922683
59* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37240828
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36509046
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33109949
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.32983407
63* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32861780
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32344646
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.31729493
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31523973
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31320052
68GATA4_25053715_ChIP-Seq_YYC3_Human1.31289234
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30266597
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30180017
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29128978
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27111059
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26891100
74CJUN_26792858_Chip-Seq_BT549_Human1.24927301
75SOX2_20726797_ChIP-Seq_SW620_Human1.24842568
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22796307
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22761478
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.22407440
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21002320
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20026220
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19936355
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19089386
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17923326
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17894601
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17880380
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17352029
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16451522
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16162891
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15981637
90* UBF1/2_26484160_Chip-Seq_HMECs_Human1.14903425
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14459368
92* BRD4_25478319_ChIP-Seq_HGPS_Human1.13925079
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13205926
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12731733
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.11931212
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11766943
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10818334
98TP53_22127205_ChIP-Seq_IMR90_Human1.09297521
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09031884
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08939486
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08067617
102* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07807356
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07673849
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07352141
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.06516710
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06266489
107KDM2B_26808549_Chip-Seq_K562_Human1.05147600
108GATA3_24758297_ChIP-Seq_MCF-7_Human1.04845183
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03720866
110OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02609185
111* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02569732
112SOX17_20123909_ChIP-Seq_XEN_Mouse1.02094811
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01917248
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01762765
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01464891
116CHD1_26751641_Chip-Seq_LNCaP_Human0.98952441
117NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98399114
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98309468
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.97365336
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96719108
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96429260
122KLF5_25053715_ChIP-Seq_YYC3_Human0.95987857
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94907726
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.92944200
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.92914336
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91577373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.89054665
2MP0008438_abnormal_cutaneous_collagen2.94697032
3MP0004272_abnormal_basement_membrane2.87339707
4MP0004084_abnormal_cardiac_muscle2.71792141
5MP0005257_abnormal_intraocular_pressure2.70596252
6MP0010234_abnormal_vibrissa_follicle2.58011018
7MP0010352_gastrointestinal_tract_polyps2.56593589
8MP0005275_abnormal_skin_tensile2.40766273
9* MP0003566_abnormal_cell_adhesion2.39474560
10MP0000537_abnormal_urethra_morphology2.22568955
11MP0005623_abnormal_meninges_morphology2.07498034
12MP0009780_abnormal_chondrocyte_physiolo1.92469703
13MP0000579_abnormal_nail_morphology1.88506884
14MP0004858_abnormal_nervous_system1.86119774
15MP0010368_abnormal_lymphatic_system1.77028612
16MP0003941_abnormal_skin_development1.72583790
17MP0004264_abnormal_extraembryonic_tissu1.66316114
18MP0003300_gastrointestinal_ulcer1.65957475
19MP0010630_abnormal_cardiac_muscle1.64527041
20MP0000750_abnormal_muscle_regeneration1.64449276
21MP0005409_darkened_coat_color1.62413361
22MP0006138_congestive_heart_failure1.59868556
23MP0006054_spinal_hemorrhage1.58422431
24MP0010030_abnormal_orbit_morphology1.55532204
25MP0003279_aneurysm1.55045263
26MP0001958_emphysema1.54571778
27MP0005023_abnormal_wound_healing1.52032969
28MP0009053_abnormal_anal_canal1.51569288
29MP0005330_cardiomyopathy1.50259064
30MP0003567_abnormal_fetal_cardiomyocyte1.49291896
31MP0003950_abnormal_plasma_membrane1.48660910
32MP0001299_abnormal_eye_distance/1.47836563
33MP0004087_abnormal_muscle_fiber1.45111461
34MP0002877_abnormal_melanocyte_morpholog1.42819735
35MP0000733_abnormal_muscle_development1.40622864
36MP0008775_abnormal_heart_ventricle1.37690809
37MP0005076_abnormal_cell_differentiation1.37647086
38MP0003828_pulmonary_edema1.36913253
39MP0000566_synostosis1.36689576
40MP0004185_abnormal_adipocyte_glucose1.34092878
41MP0000767_abnormal_smooth_muscle1.32912185
42MP0001849_ear_inflammation1.31093278
43MP0004036_abnormal_muscle_relaxation1.29826997
44MP0003091_abnormal_cell_migration1.29761862
45MP0009384_cardiac_valve_regurgitation1.29098121
46MP0002796_impaired_skin_barrier1.28825426
47MP0001879_abnormal_lymphatic_vessel1.28386092
48MP0002972_abnormal_cardiac_muscle1.27675052
49MP0005385_cardiovascular_system_phenoty1.26693006
50MP0001544_abnormal_cardiovascular_syste1.26693006
51MP0005248_abnormal_Harderian_gland1.24959602
52MP0000751_myopathy1.24770423
53MP0005503_abnormal_tendon_morphology1.24720266
54MP0002697_abnormal_eye_size1.24512739
55MP0003191_abnormal_cellular_cholesterol1.23801253
56MP0002837_dystrophic_cardiac_calcinosis1.21056400
57MP0002060_abnormal_skin_morphology1.19367899
58MP0003984_embryonic_growth_retardation1.16581366
59MP0002088_abnormal_embryonic_growth/wei1.15793120
60MP0010678_abnormal_skin_adnexa1.15380095
61MP0004782_abnormal_surfactant_physiolog1.14252710
62MP0002254_reproductive_system_inflammat1.13067878
63MP0004233_abnormal_muscle_weight1.12883297
64MP0004215_abnormal_myocardial_fiber1.09973931
65* MP0002086_abnormal_extraembryonic_tissu1.09810249
66MP0002925_abnormal_cardiovascular_devel1.09559130
67MP0001672_abnormal_embryogenesis/_devel1.08726222
68MP0005380_embryogenesis_phenotype1.08726222
69MP0003252_abnormal_bile_duct1.08199458
70MP0003806_abnormal_nucleotide_metabolis1.07664970
71MP0000462_abnormal_digestive_system1.07407588
72MP0001730_embryonic_growth_arrest1.07394299
73MP0005197_abnormal_uvea_morphology1.05752263
74MP0000749_muscle_degeneration1.04268748
75MP0009840_abnormal_foam_cell1.03869709
76MP0005058_abnormal_lysosome_morphology1.03317893
77MP0003115_abnormal_respiratory_system1.02653067
78MP0005666_abnormal_adipose_tissue1.01072605
79MP0005367_renal/urinary_system_phenotyp0.99014367
80MP0000516_abnormal_urinary_system0.99014367
81MP0004197_abnormal_fetal_growth/weight/0.97878937
82MP0005377_hearing/vestibular/ear_phenot0.97624556
83MP0003878_abnormal_ear_physiology0.97624556
84MP0002092_abnormal_eye_morphology0.97001148
85MP0000266_abnormal_heart_morphology0.96723251
86MP0005165_increased_susceptibility_to0.95751845
87MP0002128_abnormal_blood_circulation0.95199549
88MP0003942_abnormal_urinary_system0.94680050
89MP0000003_abnormal_adipose_tissue0.93990888
90MP0000762_abnormal_tongue_morphology0.92647602
91MP0002084_abnormal_developmental_patter0.92047930
92MP0003283_abnormal_digestive_organ0.91977750
93MP0003119_abnormal_digestive_system0.91015998
94MP0001614_abnormal_blood_vessel0.90435483
95MP0000534_abnormal_ureter_morphology0.90232248
96* MP0001216_abnormal_epidermal_layer0.88790963
97MP0002138_abnormal_hepatobiliary_system0.88492446
98MP0005620_abnormal_muscle_contractility0.87925911
99MP0002269_muscular_atrophy0.87832589
100MP0001915_intracranial_hemorrhage0.86819649
101MP0003755_abnormal_palate_morphology0.86268007
102MP0003385_abnormal_body_wall0.85936238
103MP0001697_abnormal_embryo_size0.85889889
104* MP0005501_abnormal_skin_physiology0.84753406
105* MP0002085_abnormal_embryonic_tissue0.84507914
106MP0000467_abnormal_esophagus_morphology0.84183849
107MP0000383_abnormal_hair_follicle0.83069621
108MP0005508_abnormal_skeleton_morphology0.82784098
109MP0008932_abnormal_embryonic_tissue0.81848642
110* MP0000432_abnormal_head_morphology0.81619862
111MP0000428_abnormal_craniofacial_morphol0.81445033
112MP0002896_abnormal_bone_mineralization0.81413022
113MP0002295_abnormal_pulmonary_circulatio0.81370597
114MP0000013_abnormal_adipose_tissue0.80635035
115MP0000747_muscle_weakness0.80580879
116MP0003221_abnormal_cardiomyocyte_apopto0.80227827
117* MP0003937_abnormal_limbs/digits/tail_de0.80158025
118MP0003935_abnormal_craniofacial_develop0.79725331
119* MP0000377_abnormal_hair_follicle0.78484432
120* MP0003453_abnormal_keratinocyte_physiol0.77608046
121MP0002111_abnormal_tail_morphology0.77425464
122* MP0002098_abnormal_vibrissa_morphology0.77409981
123MP0003045_fibrosis0.77066464
124MP0002127_abnormal_cardiovascular_syste0.76638409
125MP0009672_abnormal_birth_weight0.75503875
126MP0003329_amyloid_beta_deposits0.75450104
127MP0005408_hypopigmentation0.75338043
128MP0002234_abnormal_pharynx_morphology0.75211831
129MP0003123_paternal_imprinting0.74782168
130MP0002108_abnormal_muscle_morphology0.74197111
131MP0000350_abnormal_cell_proliferation0.73396166
132* MP0000627_abnormal_mammary_gland0.73226084
133MP0002233_abnormal_nose_morphology0.72606531
134MP0005193_abnormal_anterior_eye0.72121986
135MP0002089_abnormal_postnatal_growth/wei0.71049381
136* MP0010771_integument_phenotype0.70976903

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.24969214
2Ventricular tachycardia (HP:0004756)3.86966773
3Protrusio acetabuli (HP:0003179)3.71358562
4Premature rupture of membranes (HP:0001788)3.61032200
5Increased connective tissue (HP:0009025)3.56173433
6Ankle contracture (HP:0006466)3.45293436
7Arterial tortuosity (HP:0005116)3.40556568
8Muscle fiber splitting (HP:0003555)3.27309229
9Vascular tortuosity (HP:0004948)3.24724604
10Atrophic scars (HP:0001075)3.15452707
11Sudden death (HP:0001699)3.10157402
12Cerebral aneurysm (HP:0004944)2.99706988
13Shallow orbits (HP:0000586)2.96373550
14Hyporeflexia of lower limbs (HP:0002600)2.92193149
15Hyperacusis (HP:0010780)2.63501643
16Vertebral compression fractures (HP:0002953)2.59879885
17Lipoatrophy (HP:0100578)2.55492166
18Esophageal varix (HP:0002040)2.50260820
19Distal lower limb muscle weakness (HP:0009053)2.49889497
20Abnormality of dentin (HP:0010299)2.47958781
21Broad metatarsal (HP:0001783)2.47564992
22Natal tooth (HP:0000695)2.46474724
23Difficulty climbing stairs (HP:0003551)2.45725970
24Exercise-induced muscle cramps (HP:0003710)2.41684262
25Aortic aneurysm (HP:0004942)2.41068436
26Mildly elevated creatine phosphokinase (HP:0008180)2.39030786
27Cervical subluxation (HP:0003308)2.38656306
28Rectal prolapse (HP:0002035)2.37901646
29Aortic dissection (HP:0002647)2.36800249
30Spinal rigidity (HP:0003306)2.32552408
31Scapular winging (HP:0003691)2.30468752
32Lymphangioma (HP:0100764)2.27598940
33Aneurysm (HP:0002617)2.26405941
34Broad face (HP:0000283)2.23648850
35Vertebral clefting (HP:0008428)2.23191126
36Flat acetabular roof (HP:0003180)2.19905700
37Abnormality of proline metabolism (HP:0010907)2.16088624
38Hydroxyprolinuria (HP:0003080)2.16088624
39Hematochezia (HP:0002573)2.15999561
40Advanced eruption of teeth (HP:0006288)2.15322486
41Hypoplastic ischia (HP:0003175)2.14709892
42Distal lower limb amyotrophy (HP:0008944)2.12783354
43Fragile skin (HP:0001030)2.09968658
44Asymmetry of the thorax (HP:0001555)2.09537480
45Milia (HP:0001056)2.08911122
46Osteolytic defects of the hand bones (HP:0009699)2.08569445
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.08569445
48Atrial fibrillation (HP:0005110)2.08307966
49Deviation of the thumb (HP:0009603)2.08210400
50Metaphyseal cupping (HP:0003021)2.07701076
51Type 1 muscle fiber predominance (HP:0003803)2.06731751
52Selective tooth agenesis (HP:0001592)2.04210138
53Absent frontal sinuses (HP:0002688)2.02618323
54Ulnar bowing (HP:0003031)2.01621701
55Mitral stenosis (HP:0001718)2.00401530
56Dilated cardiomyopathy (HP:0001644)2.00085560
57Subacute progressive viral hepatitis (HP:0006572)1.99384123
58Abnormal vertebral ossification (HP:0100569)1.98284738
59Neonatal death (HP:0003811)1.97995314
60Vertebral arch anomaly (HP:0008438)1.97051686
61Mesangial abnormality (HP:0001966)1.96485883
62Abnormality of the calf musculature (HP:0001430)1.96466367
63Hand muscle atrophy (HP:0009130)1.95065474
64Mitral valve prolapse (HP:0001634)1.94979050
65Difficulty running (HP:0009046)1.93959241
66Short nail (HP:0001799)1.93676749
67Abnormality of the ischium (HP:0003174)1.92753065
68Abnormality of the left ventricular outflow tract (HP:0011103)1.91004143
69Subaortic stenosis (HP:0001682)1.91004143
70Primary atrial arrhythmia (HP:0001692)1.89771300
71Supraventricular arrhythmia (HP:0005115)1.89524113
72Mitral regurgitation (HP:0001653)1.89099076
73Abnormality of the acetabulum (HP:0003170)1.89052422
74Abnormality of carpal bone ossification (HP:0006257)1.88606792
75Insidious onset (HP:0003587)1.88296209
76Termporal pattern (HP:0011008)1.88296209
77Exostoses (HP:0100777)1.87592300
78Biliary tract neoplasm (HP:0100574)1.86356422
79Onycholysis (HP:0001806)1.86087460
80Insomnia (HP:0100785)1.85980251
81Focal segmental glomerulosclerosis (HP:0000097)1.84872837
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.84645891
83Wrist flexion contracture (HP:0001239)1.84057700
84Spinal cord compression (HP:0002176)1.83654676
85Abnormal ossification of hand bones (HP:0005921)1.83383734
86Spastic diplegia (HP:0001264)1.83101737
87Nuclear cataract (HP:0100018)1.82930311
88Multiple enchondromatosis (HP:0005701)1.82543665
89Ankyloglossia (HP:0010296)1.80187036
90Ventricular arrhythmia (HP:0004308)1.79853373
91Palpitations (HP:0001962)1.79624799
92Bladder diverticulum (HP:0000015)1.79405114
93Polycythemia (HP:0001901)1.77937522
94Supraventricular tachycardia (HP:0004755)1.77410051
95Fused cervical vertebrae (HP:0002949)1.77122986
96Short humerus (HP:0005792)1.76816181
97Trismus (HP:0000211)1.76793504
98Cardiovascular calcification (HP:0011915)1.76720502
99Proximal placement of thumb (HP:0009623)1.76216568
100Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76023735
101Vertebral hypoplasia (HP:0008417)1.76023735
102Hammertoe (HP:0001765)1.76018059
103Lower limb amyotrophy (HP:0007210)1.75908173
104Achilles tendon contracture (HP:0001771)1.75653431
105Blue sclerae (HP:0000592)1.75002583
106Dilatation of the ascending aorta (HP:0005111)1.74999599
107Hip contracture (HP:0003273)1.74918701
108Pili torti (HP:0003777)1.74511795
109Pterygium (HP:0001059)1.74422472
110Wormian bones (HP:0002645)1.74183594
111Soft skin (HP:0000977)1.73807353
112Short hallux (HP:0010109)1.73048245
113Abnormal cartilage morphology (HP:0002763)1.72748770
114Myoglobinuria (HP:0002913)1.71726806
115Micronodular cirrhosis (HP:0001413)1.71680831
116Coronal craniosynostosis (HP:0004440)1.71499880
117Arnold-Chiari malformation (HP:0002308)1.70969112
118Breech presentation (HP:0001623)1.70806400
119Elbow flexion contracture (HP:0002987)1.70579785
120Hypoglycemic coma (HP:0001325)1.70262191
121Thin bony cortex (HP:0002753)1.69937360
122Back pain (HP:0003418)1.69030456
123Abnormality of the calcaneus (HP:0008364)1.68853457
124Abnormality of the distal phalanges of the toes (HP:0010182)1.68143121
125Tetraparesis (HP:0002273)1.67664912
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.67602408
127Visceral angiomatosis (HP:0100761)1.67313957
128Abnormality of oral frenula (HP:0000190)1.66822360
129Neonatal short-limb short stature (HP:0008921)1.66821919
130Syncope (HP:0001279)1.66636241
131Upper limb amyotrophy (HP:0009129)1.66293698
132Distal upper limb amyotrophy (HP:0007149)1.66293698
133Abnormal delivery (HP:0001787)1.64857547
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63317293
135Renal duplication (HP:0000075)1.63270458
136Peritonitis (HP:0002586)1.62870146
137Missing ribs (HP:0000921)1.62816457
138Abnormality of the umbilical cord (HP:0010881)1.62544453
139Radial bowing (HP:0002986)1.61952303
140EMG: myopathic abnormalities (HP:0003458)1.61436889
141Joint laxity (HP:0001388)1.61287018
142Cerebral inclusion bodies (HP:0100314)1.60274465
143Limb-girdle muscle atrophy (HP:0003797)1.59675157
144Abnormality of the Achilles tendon (HP:0005109)1.59539864
145Overriding aorta (HP:0002623)1.59449719
146Hyperextensible skin (HP:0000974)1.59186853
147Neurofibrillary tangles (HP:0002185)1.58295724
148Bronchomalacia (HP:0002780)1.57829360
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56178717
150Aplasia involving bones of the extremities (HP:0009825)1.56103811
151Aplasia involving bones of the upper limbs (HP:0009823)1.56103811
152Aplasia of the phalanges of the hand (HP:0009802)1.56103811
153Disproportionate tall stature (HP:0001519)1.56060529
154Long toe (HP:0010511)1.55177543
155Bowel diverticulosis (HP:0005222)1.54411731
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54157607
157Vascular calcification (HP:0004934)1.51179885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.83503601
2TTN3.30073205
3TRIB33.01621952
4PKN22.88172611
5STK38L2.82096947
6DMPK2.51711816
7LATS12.51173263
8MST42.39231542
9EPHB22.04916075
10NUAK12.00569972
11NTRK11.99594105
12PBK1.93588286
13SMG11.90483184
14PIK3CA1.86116711
15MET1.85797270
16RIPK11.81319280
17PDGFRA1.77874729
18PTK61.76032061
19PAK41.69184138
20LMTK21.68107857
21TIE11.66995561
22LRRK21.56981926
23CDK121.55710597
24NEK11.53151820
25FER1.51676159
26RPS6KB21.42207687
27ILK1.41388968
28DDR21.39369488
29MYLK1.34674103
30MAP3K31.30941256
31STK101.30632556
32MAP2K21.28867828
33TGFBR11.25918003
34STK31.25286307
35IRAK31.24786878
36PTK21.21002603
37KDR1.20636411
38LATS21.18146052
39TSSK61.18069829
40EEF2K1.17165974
41MST1R1.14454410
42TESK11.11628288
43EPHB11.05607239
44MAP3K81.01313685
45SIK11.00905879
46TRPM71.00526701
47PAK21.00050662
48TTK1.00001668
49BMX0.99464733
50PDK30.96884437
51PDK40.96884437
52MTOR0.96827611
53TGFBR20.94302574
54FLT30.93634330
55PDK20.93024187
56MAP3K70.91322985
57NEK90.90214490
58CDK60.88835660
59ERN10.87637972
60MAP3K120.86523282
61STK240.85033179
62EIF2AK10.84583559
63FRK0.83430396
64MAP3K100.83405816
65ROCK10.82525529
66PAK30.81416981
67RPS6KA40.78040852
68FGFR10.77909697
69PDGFRB0.77211403
70MOS0.76816159
71MAPKAPK30.76211966
72MAP2K10.72903638
73MAP2K30.72423318
74FGFR40.70658421
75NME20.70460268
76OBSCN0.70050853
77LIMK10.69027272
78CDK40.68756676
79ZAK0.66122879
80ARAF0.64999154
81KSR10.64918121
82MAP3K90.64171871
83ROCK20.64103320
84AURKB0.63604151
85WEE10.62531661
86NEK60.61380983
87WNK40.61234608
88PRKG20.60922333
89STK40.60479590
90SCYL20.57326353
91RPS6KA20.55399644
92PRKD30.52487661
93PRKD10.49655651
94EPHA30.49602870
95CAMK2G0.48442566
96NEK20.47749317
97CHUK0.47596773
98CAMK1G0.47451461
99PASK0.46118175
100ERBB20.45889270
101PAK10.45528793
102BCR0.45421822
103RET0.43987546
104KSR20.43971778
105AKT20.42214366
106CAMK1D0.41727901
107BCKDK0.41443820
108ABL20.41303783
109CLK10.41233704
110STK380.41138668
111MELK0.40697671
112CAMK2D0.39866038
113ERBB40.39636834
114ERBB30.39411731
115FGFR20.38605211
116MAP3K20.38557880
117GSK3A0.38251678
118MUSK0.37885460
119BRSK20.37106170
120CDC42BPA0.37086525
121MAP3K60.37058718
122PIM20.35155849
123AKT30.34409455
124ICK0.33998657
125PRKCI0.33937961
126CDK180.33854801
127CDK90.33106127
128BUB10.32185567
129CDK70.32033585
130CDK150.30869985
131BRSK10.30637460
132CAMK2B0.27272039

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.87127811
2ECM-receptor interaction_Homo sapiens_hsa045122.77826073
3* Adherens junction_Homo sapiens_hsa045202.69724973
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46983129
5Focal adhesion_Homo sapiens_hsa045102.20236577
6Fatty acid degradation_Homo sapiens_hsa000712.15942320
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.15487142
8* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14375286
9* Tight junction_Homo sapiens_hsa045302.08561868
10Small cell lung cancer_Homo sapiens_hsa052222.06691305
11Dilated cardiomyopathy_Homo sapiens_hsa054141.95429142
12Proteoglycans in cancer_Homo sapiens_hsa052051.86546591
13* Hippo signaling pathway_Homo sapiens_hsa043901.85853617
14Carbon metabolism_Homo sapiens_hsa012001.77892540
15Viral myocarditis_Homo sapiens_hsa054161.70569615
16* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56239798
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48727226
18Pentose phosphate pathway_Homo sapiens_hsa000301.46643652
19TGF-beta signaling pathway_Homo sapiens_hsa043501.46383008
20Bladder cancer_Homo sapiens_hsa052191.45528904
21Amoebiasis_Homo sapiens_hsa051461.43339225
22* Leukocyte transendothelial migration_Homo sapiens_hsa046701.39706888
23MicroRNAs in cancer_Homo sapiens_hsa052061.39387136
24Basal cell carcinoma_Homo sapiens_hsa052171.38026956
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37821666
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36245921
27Fatty acid metabolism_Homo sapiens_hsa012121.33764969
28Protein digestion and absorption_Homo sapiens_hsa049741.33430401
29Propanoate metabolism_Homo sapiens_hsa006401.33173589
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31037540
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.29749863
32Pyruvate metabolism_Homo sapiens_hsa006201.24341733
33Vibrio cholerae infection_Homo sapiens_hsa051101.18594366
34Prion diseases_Homo sapiens_hsa050201.18584385
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18001568
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17977705
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16255280
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15603212
39Nitrogen metabolism_Homo sapiens_hsa009101.12884370
40Other glycan degradation_Homo sapiens_hsa005111.12625544
41Steroid biosynthesis_Homo sapiens_hsa001001.12185565
42p53 signaling pathway_Homo sapiens_hsa041151.11514814
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09307278
44Toxoplasmosis_Homo sapiens_hsa051451.07575346
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07438709
46PPAR signaling pathway_Homo sapiens_hsa033201.04427794
47Biosynthesis of amino acids_Homo sapiens_hsa012301.04010352
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03775236
49One carbon pool by folate_Homo sapiens_hsa006701.03320519
50Fat digestion and absorption_Homo sapiens_hsa049751.02680113
51Axon guidance_Homo sapiens_hsa043600.99748760
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99241972
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97504019
54Thyroid cancer_Homo sapiens_hsa052160.96426659
55Selenocompound metabolism_Homo sapiens_hsa004500.96295958
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95728758
57Sphingolipid metabolism_Homo sapiens_hsa006000.95284944
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92398732
59Insulin resistance_Homo sapiens_hsa049310.92384685
60Tryptophan metabolism_Homo sapiens_hsa003800.91203757
61Chronic myeloid leukemia_Homo sapiens_hsa052200.89431415
62N-Glycan biosynthesis_Homo sapiens_hsa005100.89206894
63Lysine degradation_Homo sapiens_hsa003100.88887564
64HIF-1 signaling pathway_Homo sapiens_hsa040660.87653136
65Renin-angiotensin system_Homo sapiens_hsa046140.87423346
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.86921592
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86338861
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86051373
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85516301
70* Pathways in cancer_Homo sapiens_hsa052000.83052206
71Notch signaling pathway_Homo sapiens_hsa043300.82965932
72Cell cycle_Homo sapiens_hsa041100.81210778
73Hedgehog signaling pathway_Homo sapiens_hsa043400.81007389
74Histidine metabolism_Homo sapiens_hsa003400.80917495
75Vitamin B6 metabolism_Homo sapiens_hsa007500.80411976
76Mineral absorption_Homo sapiens_hsa049780.79299389
77Sulfur metabolism_Homo sapiens_hsa009200.79156507
78* Endometrial cancer_Homo sapiens_hsa052130.78007171
79Thyroid hormone synthesis_Homo sapiens_hsa049180.76352724
80Glutathione metabolism_Homo sapiens_hsa004800.76126339
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74846322
82Tyrosine metabolism_Homo sapiens_hsa003500.73813980
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.73618385
84Lysosome_Homo sapiens_hsa041420.73611470
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71031960
86AMPK signaling pathway_Homo sapiens_hsa041520.70806384
87Viral carcinogenesis_Homo sapiens_hsa052030.70641785
88Galactose metabolism_Homo sapiens_hsa000520.69298125
89RNA transport_Homo sapiens_hsa030130.67823763
90Starch and sucrose metabolism_Homo sapiens_hsa005000.67430055
91HTLV-I infection_Homo sapiens_hsa051660.66673932
92Fatty acid elongation_Homo sapiens_hsa000620.66151867
93Arginine and proline metabolism_Homo sapiens_hsa003300.65513029
94Gap junction_Homo sapiens_hsa045400.65249232
95Melanogenesis_Homo sapiens_hsa049160.64558922
96Prostate cancer_Homo sapiens_hsa052150.63861963
97Apoptosis_Homo sapiens_hsa042100.61967282
98ErbB signaling pathway_Homo sapiens_hsa040120.61950132
99Glioma_Homo sapiens_hsa052140.60065514
100Fatty acid biosynthesis_Homo sapiens_hsa000610.59994597
101Endocytosis_Homo sapiens_hsa041440.58776240
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.57128227
103Wnt signaling pathway_Homo sapiens_hsa043100.56224513
104Melanoma_Homo sapiens_hsa052180.55266483
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53839222
106Complement and coagulation cascades_Homo sapiens_hsa046100.53151914
107Estrogen signaling pathway_Homo sapiens_hsa049150.52067679
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51569959
109Colorectal cancer_Homo sapiens_hsa052100.51518445
110Arginine biosynthesis_Homo sapiens_hsa002200.51353206
111Phenylalanine metabolism_Homo sapiens_hsa003600.50995916
112Butanoate metabolism_Homo sapiens_hsa006500.49962313
113TNF signaling pathway_Homo sapiens_hsa046680.48679780
114Legionellosis_Homo sapiens_hsa051340.46948182
115Bile secretion_Homo sapiens_hsa049760.46004909
116mTOR signaling pathway_Homo sapiens_hsa041500.45753279
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44777377
118Renal cell carcinoma_Homo sapiens_hsa052110.44448989
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43900729
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43822937
121Caffeine metabolism_Homo sapiens_hsa002320.43517328
122Salmonella infection_Homo sapiens_hsa051320.43313624
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43164335
124Fructose and mannose metabolism_Homo sapiens_hsa000510.42936825
125Pancreatic cancer_Homo sapiens_hsa052120.42786160
126Shigellosis_Homo sapiens_hsa051310.41806022
127Rap1 signaling pathway_Homo sapiens_hsa040150.41056243
128Insulin signaling pathway_Homo sapiens_hsa049100.38675721
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37821518
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36943111
131Platelet activation_Homo sapiens_hsa046110.35914730
132Chemical carcinogenesis_Homo sapiens_hsa052040.33646368
133Mismatch repair_Homo sapiens_hsa034300.33350155
134beta-Alanine metabolism_Homo sapiens_hsa004100.33091319

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